Tag Archives: São Paulo State University (UNESP)

Curcumin nanoemulsion for treatment of intestinal inflammation

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Most of my posts about research into curcumin (which is derived from turmeric) treatments has been based in India but this work according to a March 7, 2024 news item on phys.org comes from Brazil, Note: If you’re interested in more about turmeric/curcumin, I have a link to more information at the end of this posting,

A nanoemulsion containing particles of curcumin, which is known to have anti-inflammatory and antioxidant properties, has been found capable of modulating the gut microbiota of mice with intestinal inflammation in experiments conducted by researchers at the University of Western São Paulo (UNOESTE) and São Paulo State University (UNESP) in Brazil.

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The image being used to illustrate an aspect of this research is a bit of a mystery. Is curcumin bright orange? And, it seems like a lot for a mouse,

Caption: The nanoemulsion enhanced the bioavailability of the curcumin and resulted in increased abundance of beneficial bacteria in the murine gut microbiota. Credit: UNOESTE

A March 6, 2024 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) press release (also on EurekAlert but published March 7, 2024) by Thais Szegö, which originated the news item, Note: Links have been removed,

Curcumin, a natural substance belonging to the group of bioactive compounds called curcuminoids, is a yellow polyphenolic pigment found in the turmeric plant (Curcuma longa). It has gained prominence in treatments to combat inflammatory intestinal disorders, but its bioavailability is low when it is administered orally. This problem is exacerbated in patients with Crohn’s disease, ulcerative colitis and other conditions associated with inflammation of the digestive tract and gut microbiota alterations. 

To enhance the efficacy of curcumin in such cases, the scientists developed an emulsion containing nanometric particles of the compound (invisible to the naked eye). “The research comprised two stages. The first entailed producing a nanoemulsion to deliver the curcumin. In the second, we evaluated its stability, morphology and physicochemical properties,” said Lizziane Kretli Winkelströter Eller, last author of the article and a professor at UNOESTE. 

Next, to test the action of the nanoemulsion in mice, the researchers induced intestinal inflammation using a drug called indomethacin and administered the nanoemulsion orally for 14 days. At the end of this period, they evaluated the intestinal inflammation by macroscopic, histopathological and metagenomic analysis.

The results showed that the nanoemulsion effectively improved the bioavailability of curcumin and modulated the gut microbiota of the mice after the damage was caused by the drug, increasing the presence there of beneficial bacteria. “The nanoemulsion didn’t lead to a significant improvement in the intestinal inflammation, but the relative abundance of Lactobacillus bacteria was about 25% higher in the mice treated with curcumin nanoemulsion than in the control group,” Eller said.

The authors of the study, the first to measure the effects of curcumin nanoemulsion in this way, stressed the importance of developing novel formulations that enhance the efficacy of curcumin in preventing and treating inflammatory bowel disease, since it has proved to be a valid alternative to existing treatments, which are expensive and have significant side effects. 

The group continues to conduct research on the potential of nanoformulations to deliver nutraceuticals (food elements of plant or animal origin with significant health benefits). “Specifically with regard to the curcumin nanoemulsion, we’re adjusting the formulation to increase the bioavailability of the active ingredient and will soon apply it in other protocols for the prevention and treatment of intestinal damage,” Eller said. 

About São Paulo Research Foundation (FAPESP)

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe.

Here’s a link to and a citation for the paper,

Evaluation of curcumin nanoemulsion effect to prevent intestinal damage by Maria Vitória Minzoni de Souza Iacia, Maria Eduarda Ferraz Mendes, Karolinny Cristiny de Oliveira Vieira, Gilia Cristine Marques Ruiz, Carlos José Leopoldo Constantino, Cibely da Silva Martin, Aldo Eloizo Job, Gisele Alborghetti Nai, and Lizziane Kretli Winkelstroter Eller. International Journal of Pharmaceutics Volume 650, 25 January 2024, 123683 DOI: https://doi.org/10.1016/j.ijpharm.2023.123683

This paper is behind a paywall.

For the curious, Johns Hopkins Medical School has a posting by Mary-Eve Brown about turmeric, its benefits, and its use in Ayurvedic medicine.

In Brazil: Applications open for July 3 – 15, 2023 School of Advanced Science on Nanotechnology, Agriculture and Environment

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According to the December 15, 2022 Fundação de Amparo à Pesquisa do Estado de São Paulo press release on EurekAlert applications will be received until February 5, 2023,

The São Paulo School of Advanced Science on Nanotechnology, Agriculture and Environment (SPSAS NanoAgri&Enviro) will be held on July 3-15 at the Brazilian Center for Research in Energy and Materials (CNPEM) in Campinas, São Paulo state, Brazil. 

Reporters are invited to reach the organizing committee through the email eventos@cnpem.br, for opportunities to visit the school and sessions.

Designed to meet an increasing level of content depth and complexity, the SPSAS NanoAgri&Enviro will cover the following topics: i) Nanotechnology, innovation, and sustainability; ii) Synthesis, functionalization, and characterization of nanomaterials; iii) Characterization of nanoparticles in complex matrices; iv) Synchrotron Light for nano-agri-environmental research; v) Biological and environmental applications of nanoparticles; vi) Nanofertilizers and Nanoagrochemicals; vii) Ecotoxicology, geochemistry and nanobiointerfaces; viii) Nanosafety and Nanoinformatics; ix) International harmonization and regulatory issues; x) Environmental implications of nanotechnology.

Discussions regarding those topics will benefit from the participation of internationally renowned scientists as speakers, including Mark V. Wiesner (Duke University), Iseult Lynch (University of Birmingham), Leonardo F. Fraceto (São Paulo State University – UNESP), Gregory V. Lowry (Carnegie Mellon University), Marisa N. Fernandes (Federal University of São Carlos – UFSCar), Caue Ribeiro (Brazilian Agricultural Research Corporation – EMBRAPA), and others.

The program also comprise didactic activities programmed among theoretical interactive classes, practical experiments (hands-on), and technical visits to world-class facilities and specialized laboratories from several institutions in São Paulo state.

The São Paulo Research Foundation (FAPESP) is supporting the event through its São Paulo School of Advanced Science Program (SPSAS http://espca.fapesp.br/home). Undergraduate students, postdoctoral fellows and researchers who are already working on subjects relating to the school can apply to receive financial support to cover the cost of air travel, accommodation and meals. Applications must be submitted by February 5, 2023.

More information: https://pages.cnpem.br/spsasnano/.

I looked up the criteria for eligible applicants and found this among the other criteria (from the Applications page),

Participating students must be enrolled in undergraduate or graduate courses in Brazil or abroad, being potential candidates for Master’s, Doctoral or Post-Doctoral internships in higher education and research institutions in the state of São Paulo. Doctors may also be accepted. [emphases mine]

If I read that correctly, it means that people who are considering or planning to further their studies in the state of São Paulo are being invited to apply.

I recognized two of the speakers’ names, Mark Wiesner and Iseult Lynch both of whom have been mentioned here a number of times as has Gregory V. Lowry. (Wiesner very kindly helped with an art/sci project I was involved with [Steep] a number of years ago.)

Good luck with your application!

Proposed nanodevice made possible by particle that is its own antiparticle (Majorana particle)

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I’m not sure how much the mystery of Ettore Majorana’s disappearance in 1938 has to do with the latest research from Brazil on Majorana particles but it’s definitely fascinating,. From an April 6, 2018 news item on ScienceDaily,

In March 1938, the young Italian physicist Ettore Majorana disappeared mysteriously, leaving his country’s scientific community shaken. The episode remains unexplained, despite Leonardo Scascia’s attempt to unravel the enigma in his book The Disappearance of Majorana (1975).

Majorana, whom Enrico Fermi called a genius of Isaac Newton’s stature, vanished a year after making his main contribution to science. In 1937, when he was only 30, Majorana hypothesized a particle that is its own anti-particle and suggested that it might be the neutrino, whose existence had recently been predicted by Fermi and Wolfgang Pauli.

Eight decades later, Majorana fermions, or simply majoranas, are among the objects most studied by physicists. In addition to neutrinos — whose nature, whether or not they are majoranas, is one of the investigative goals of the mega-experiment Dune — another class not of fundamental particles but of quasi-particles or apparent particles has been investigated in the field of condensed matter. These Majorana quasi-particles can emerge as excitations in topological superconductors.

An April 6, 2018 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) press release on EurekAlert, which originated the news item,  reveals more about the Brazilian research (Note: Links have been removed),

A new study by PhD student Luciano Henrique Siliano Ricco with a scholarship from the São Paulo Research Foundation – FAPESP, in collaboration with his supervisor Antonio Carlos Ferreira Seridonio and others, was conducted on the Ilha Solteira campus of São Paulo State University (UNESP) in Brazil and described in an article in Scientific Reports.

“We propose a theoretical device that acts as a thermoelectric tuner – a tuner of heat and charge – assisted by Majorana fermions,” Seridonio said.

The device consists of a quantum dot (QD), represented in the Figure A by the symbol ε1. QDs are often called “artificial atoms.” In this case, the QD is located between two metallic leads at different temperatures.

The temperature difference is fundamental to allowing thermal energy to flow across the QD. A quasi-one-dimensional superconducting wire – called a Kitaev wire after its proponent, Russian physicist Alexei Kitaev, currently a professor at the California Institute of Technology (Caltech) in the US – is connected to the QD.

In this study, the Kitaev wire was ring- or U-shaped and had two majoranas (η1 and η2) at its edges. The majoranas emerge as excitations characterized by zero-energy modes.

“When the QD is coupled to only one side of the wire, the system behaves resonantly with regard to electrical and thermal conductance. In other words, it behaves like a thermoelectric filter,” said the principal investigator for the FAPESP fellowship.

“I should stress that this behavior as a filter for thermal and electrical energy occurs when the two majoranas ‘see’ each other via the wire, but only one of them ‘sees’ the QD in the connection.”

Another possibility investigated by the researchers involved making the QD “see” the two majoranas at the same time by connecting it to both ends of the Kitaev wire.

“By making the QD ‘see’ more of η1 or η2, i.e., by varying the system’s asymmetry, we can use the artificial atom as a tuner, where the thermal or electrical energy that flows through it is redshifted or blueshifted,” Seridonio said (see Figure B for illustrative explanation).

This theoretical paper, he added, is expected to contribute to the development of thermoelectric devices based on Majorana fermions.

Here’s a link to and a citation for the paper,

Tuning of heat and charge transport by Majorana fermions by L. S. Ricco, F. A. Dessotti, I. A. Shelykh, M. S. Figueira & A. C. Seridonio. Scientific Reportsvolume 8, Article number: 2790 (2018) doi:10.1038/s41598-018-21180-9 Published online: 12 February 2018

This paper is open access.

As I prepared to publish this piece I stumbled across a sad Sept. 3, 2018 article about Brazil and its overnight loss of heritage in a fire by Henry Grabar for slate.com (Note: Links have been removed),

On Sunday night, a fire ripped through Brazil’s National Museum in Rio de Janeiro, destroying the country’s most valuable storehouse of natural and anthropological history within hours.

Most of the 20 million items housed inside—including the skull of Luzia, the oldest human remains ever found in the Americas; one of the world’s largest archives of South America’s indigenous cultures; more than 26,000 fossils, 55,000 stuffed birds, and 5 million insect specimens; and a library of more than 500,000 books—are thought to have been destroyed.

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The loss is a symptom of a larger problem as Grabar notes in his article.