Monthly Archives: February 2018

The devil’s (i.e., luciferase) in the bioluminescent plant

The American Chemical Society (ACS) and the Massachusetts Institute of Technology (MIT) have both issued news releases about the latest in bioluminescence.The researchers tested their work on watercress, a vegetable that was viewed in almost sacred terms in my family; it was not easily available in Vancouver (Canada) when I was child.

My father would hunt down fresh watercress by checking out the Chinese grocery stores. He could spot the fresh stuff from across the street while driving at 30 miles or more per hour. Spotting it entailed an immediate hunt for parking (my father hated to pay so we might have go around the block a few times or more) and a dash out of the car to ensure that he got his watercress before anyone else spotted it. These days it’s much more easily available and, thankfully, my father has passed on so he won’t have to think about glowing watercress.

Getting back to bioluninescent vegetable research, the American Chemical Society’s Dec. 13, 2017 news release on EurekAlert (and as a Dec. 13, 2017 news item on ScienceDaily) makes the announcement,

The 2009 film “Avatar” created a lush imaginary world, illuminated by magical, glowing plants. Now researchers are starting to bring this spellbinding vision to life to help reduce our dependence on artificial lighting. They report in ACS’ journal Nano Letters a way to infuse plants with the luminescence of fireflies.

Nature has produced many bioluminescent organisms, however, plants are not among them. Most attempts so far to create glowing greenery — decorative tobacco plants in particular — have relied on introducing the genes of luminescent bacteria or fireflies through genetic engineering. But getting all the right components to the right locations within the plants has been a challenge. To gain better control over where light-generating ingredients end up, Michael S. Strano and colleagues recently created nanoparticles that travel to specific destinations within plants. Building on this work, the researchers wanted to take the next step and develop a “nanobionic,” glowing plant.

The team infused watercress and other plants with three different nanoparticles in a pressurized bath. The nanoparticles were loaded with light-emitting luciferin; luciferase, which modifies luciferin and makes it glow; and coenzyme A, which boosts luciferase activity. Using size and surface charge to control where the sets of nanoparticles could go within the plant tissues, the researchers could optimize how much light was emitted. Their watercress was half as bright as a commercial 1 microwatt LED and 100,000 times brighter than genetically engineered tobacco plants. Also, the plant could be turned off by adding a compound that blocks luciferase from activating luciferin’s glow.

Here’s a video from MIT detailing their research,

A December 13, 2017 MIT news release (also on EurekAlert) casts more light on the topic (I couldn’t resist the word play),

Imagine that instead of switching on a lamp when it gets dark, you could read by the light of a glowing plant on your desk.

MIT engineers have taken a critical first step toward making that vision a reality. By embedding specialized nanoparticles into the leaves of a watercress plant, they induced the plants to give off dim light for nearly four hours. They believe that, with further optimization, such plants will one day be bright enough to illuminate a workspace.

“The vision is to make a plant that will function as a desk lamp — a lamp that you don’t have to plug in. The light is ultimately powered by the energy metabolism of the plant itself,” says Michael Strano, the Carbon P. Dubbs Professor of Chemical Engineering at MIT and the senior author of the study

This technology could also be used to provide low-intensity indoor lighting, or to transform trees into self-powered streetlights, the researchers say.

MIT postdoc Seon-Yeong Kwak is the lead author of the study, which appears in the journal Nano Letters.

Nanobionic plants

Plant nanobionics, a new research area pioneered by Strano’s lab, aims to give plants novel features by embedding them with different types of nanoparticles. The group’s goal is to engineer plants to take over many of the functions now performed by electrical devices. The researchers have previously designed plants that can detect explosives and communicate that information to a smartphone, as well as plants that can monitor drought conditions.

Lighting, which accounts for about 20 percent of worldwide energy consumption, seemed like a logical next target. “Plants can self-repair, they have their own energy, and they are already adapted to the outdoor environment,” Strano says. “We think this is an idea whose time has come. It’s a perfect problem for plant nanobionics.”

To create their glowing plants, the MIT team turned to luciferase, the enzyme that gives fireflies their glow. Luciferase acts on a molecule called luciferin, causing it to emit light. Another molecule called co-enzyme A helps the process along by removing a reaction byproduct that can inhibit luciferase activity.

The MIT team packaged each of these three components into a different type of nanoparticle carrier. The nanoparticles, which are all made of materials that the U.S. Food and Drug Administration classifies as “generally regarded as safe,” help each component get to the right part of the plant. They also prevent the components from reaching concentrations that could be toxic to the plants.

The researchers used silica nanoparticles about 10 nanometers in diameter to carry luciferase, and they used slightly larger particles of the polymers PLGA and chitosan to carry luciferin and coenzyme A, respectively. To get the particles into plant leaves, the researchers first suspended the particles in a solution. Plants were immersed in the solution and then exposed to high pressure, allowing the particles to enter the leaves through tiny pores called stomata.

Particles releasing luciferin and coenzyme A were designed to accumulate in the extracellular space of the mesophyll, an inner layer of the leaf, while the smaller particles carrying luciferase enter the cells that make up the mesophyll. The PLGA particles gradually release luciferin, which then enters the plant cells, where luciferase performs the chemical reaction that makes luciferin glow.

The researchers’ early efforts at the start of the project yielded plants that could glow for about 45 minutes, which they have since improved to 3.5 hours. The light generated by one 10-centimeter watercress seedling is currently about one-thousandth of the amount needed to read by, but the researchers believe they can boost the light emitted, as well as the duration of light, by further optimizing the concentration and release rates of the components.

Plant transformation

Previous efforts to create light-emitting plants have relied on genetically engineering plants to express the gene for luciferase, but this is a laborious process that yields extremely dim light. Those studies were performed on tobacco plants and Arabidopsis thaliana, which are commonly used for plant genetic studies. However, the method developed by Strano’s lab could be used on any type of plant. So far, they have demonstrated it with arugula, kale, and spinach, in addition to watercress.

For future versions of this technology, the researchers hope to develop a way to paint or spray the nanoparticles onto plant leaves, which could make it possible to transform trees and other large plants into light sources.

“Our target is to perform one treatment when the plant is a seedling or a mature plant, and have it last for the lifetime of the plant,” Strano says. “Our work very seriously opens up the doorway to streetlamps that are nothing but treated trees, and to indirect lighting around homes.”

The researchers have also demonstrated that they can turn the light off by adding nanoparticles carrying a luciferase inhibitor. This could enable them to eventually create plants that shut off their light emission in response to environmental conditions such as sunlight, the researchers say.

Here’s a link to and a citation for the paper,

A Nanobionic Light-Emitting Plant by Seon-Yeong Kwak, Juan Pablo Giraldo, Min Hao Wong, Volodymyr B. Koman, Tedrick Thomas Salim Lew, Jon Ell, Mark C. Weidman, Rosalie M. Sinclair, Markita P. Landry, William A. Tisdale, and Michael S. Strano. Nano Lett., 2017, 17 (12), pp 7951–7961 DOI: 10.1021/acs.nanolett.7b04369 Publication Date (Web): November 17, 2017

Copyright © 2017 American Chemical Society

This paper is behind a paywall.

Carbon nanotubes for enhanced wheat growth?

It’s been a long time (Oct. 22, 2009 posting; scroll down about 20% of the way) since I’ve written about carbon nanotubes and their possible use in agriculture but now a December 6, 2017 news item on ScienceDaily raises the topic again,

The introduction of purified carbon nanotubes appears to have a beneficial effect on the early growth of wheatgrass, according to Rice University scientists. But in the presence of contaminants, those same nanotubes could do great harm.

The Rice lab of chemist Andrew Barron grew wheatgrass in a hydroponic garden to test the potential toxicity of nanoparticles on the plant. To their surprise, they found one type of particle dispersed in water helped the plant grow bigger and faster.

They suspect the results spring from nanotubes’ natural hydrophobic (water-avoiding) nature that in one experiment apparently facilitated the plants’ enhanced uptake of water.

The research appears in the Royal Society of Chemistry journal Environmental Science: Nano.

A December 6, 2017 Rice University news release (also on EurekAlert), which originated the news item, expands on the theme,

The lab mounted the small-scale study with the knowledge that the industrial production of nanotubes will inevitably lead to their wider dispersal in the environment. The study cited rapid growth in the market for nanoparticles in drugs, cosmetic, fabrics, water filters and military weapons, with thousands of tons produced annually.

Despite their widespread use, Barron said few researchers have looked at the impact of environmental nanoparticles — whether natural or man-made — on plant growth.

The researchers planted wheatgrass seeds in multiple replicates in cotton wool and fed them with dispersions that contained raw single-walled or multi-walled nanotubes, purified single-walled nanotubes or iron oxide nanoparticles that mimicked leftover catalyst often attached to nanotubes. The solutions were either water or tetrahydrofuran (THF), an industrial solvent. Some of the seeds were fed pure water or THF as a control.

Rice University researchers tested the effects of carbon nanotubes on the growth of wheatgrass. While some showed no effect, purified single-walled nanotubes in water (5) enhanced the plants' growth, while the same nanotubes in a solvent (6) retarded their development. The photos at left show the plants after four days and at right after eight days, with odd-numbered plants growing in water and evens in a solvent. Numbers 1 and 2 are controls without nanotubes; 3-4 contain raw single-walled tubes; 5-6 purified single-walled tubes; 7-8 raw multi-walled tubes; 9-10 low-concentration iron-oxide nanoparticles and 11-12 high-concentration iron-oxide nanoparticles.

Rice University researchers tested the effects of carbon nanotubes on the growth of wheatgrass. While some showed no effect, purified single-walled nanotubes in water (5) enhanced the plants’ growth, while the same nanotubes in a solvent (6) retarded their development. The photos at left show the plants after four days and at right after eight days, with odd-numbered plants growing in water and evens in a solvent. Numbers 1 and 2 are controls without nanotubes; 3-4 contain raw single-walled tubes; 5-6 purified single-walled tubes; 7-8 raw multi-walled tubes; 9-10 low-concentration iron-oxide nanoparticles and 11-12 high-concentration iron-oxide nanoparticles. Click on the image for a larger version. Photos by Seung Mook Lee

After eight days, the plantings showed that purified single-walled nanotubes in water enhanced the germination rate and shoot growth of wheatgrass, which grew an average of 13 percent larger than plants in plain water. Raw single- and multi-walled nanotubes and particles in either solution had little effect on the plants’ growth, they found.

However, purified single-walled nanotubes in THF retarded plant development by 45 percent compared to single-walled nanotubes in water, suggesting the nanotubes act as a carrier for the toxic substance.

The concern, Barron said, is that if single-walled nanotubes combine with organic pollutants like pesticides, industrial chemicals or solvents in the environment, they may concentrate and immobilize the toxins and enhance their uptake by plants.

Nothing seen in the limited study indicated whether carbon nanotubes in the environment, and potentially in plants, will rise up the food chain and be harmful to humans, he said.

On the other hand, the researchers said it may be worth looking at whether hydrophobic substrates that mimic the positive effects observed in single-walled nanotubes could be used for high-efficiency channeling of water to seeds.

“Our work confirms the importance of thinking of nanomaterials as part of a system rather in isolation,” Barron said. “It is the combination with other compounds that is important to understand.”

Seung Mook Lee, a former visiting student research assistant from Memorial High School in Houston and now an undergraduate student at the University of California, Berkeley, is lead author of the paper. Co-authors are Rice research scientist Pavan Raja and graduate student Gibran Esquenazi. Barron is the Charles W. Duncan Jr.–Welch Professor of Chemistry and a professor of materials science and nanoengineering at Rice and the Sêr Cymru Chair of Low Carbon Energy and Environment at Swansea University, Wales (UK).

The Welsh Government Sêr Cymru Program and the Robert A. Welch Foundation supported the research.

Here’s a link to and a citation for the paper,

Effect of raw and purified carbon nanotubes and iron oxide nanoparticles on the growth of wheatgrass prepared from the cotyledons of common wheat (triticum aestivum) by Seung Mook Lee, Pavan M. V. Raja, Gibran L. Esquenazi, and Andrew R. Barron. Environ. Sci.: Nano, 2018, Advance Article DOI: 10.1039/C7EN00680B First published on 09 Nov 2017

This paper appears to be behind a paywall.

Are copper nanoparticles good candidates for synthesizing medicine?

This research appears to be a collaboration between Russian and Indian scientists. From a December 5, 2017 news item on Nanowerk (Note: A link has been removed),

Chemists of Ural Federal University with colleagues from India proved the effectiveness of copper nanoparticles as a catalyst on the example of analysis of 48 organic synthesis reactions (Coordination Chemistry Reviews, “Copper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesis”).

One of the advantages of the catalyst is its insolubility in traditional organic solvents. This makes copper nanoparticles a valuable alternative to heavy metal catalysts, for example palladium, which is currently used for the synthesis of many pharmaceuticals and is toxic for cells.

“Copper nanoparticles are an ideal variant of a heterophasic catalyst, since they exist in a wide variety of geometric shapes and sizes, which directly affects the surface of effective mass transfer, so reactions in the presence of this catalyst are characterized by shorter reaction times, selectivity and better yields,” says co-author Grigory Zyryanov, Doctor of Chemistry, Associate Professor of the Department of Organic and Biomolecular Chemistry of UrFU.

A December 11, 2017 (there can be a gap between distributing a press release and posting it on the home website) Ural Federal University press release, which originated the news item, makes the case for copper nanoparticles as catalytic agents,

Copper nanoparticles are inexpensive since there are many simple ways to obtain them from cheap raw materials and these methods are constantly being modified. As a result, it is possible to receive a highly porous structure of catalyst based on copper nanoparticles with a pore size of several tens to several hundred nanometers. Due to the small particle size, the area of the catalytic surface is enormous. Moreover, due to the insolubility of copper nanoparticles, the reactions catalyzed by them go on the surface of the catalyst. After the reaction is completed, the copper nanoparticles that do not interact with the solvents are easily removed, which guarantees the absence of the catalyst admixture in the composition of the final product. These catalysts are already in demand for organic synthesis by the methods of “green chemistry”. Its main principles are simplicity, cheapness, safety of production, recyclability of the catalysts.

One of the promising areas of application of the copper nanoparticle catalyst is, first of all, the creation of medical products using cross-coupling reactions. In 2010, for work in the field of palladium catalyzed cross-coupling reactions, the Nobel Prize in Chemistry was awarded to scientists from Japan and the USA: Richard Heck, Ei-ichi Negishi and Akira Suzuki. Despite worldwide recognition, palladium catalyzed cross-coupling reactions are undesirable for the synthesis of most medications due to the toxicity of palladium for living cells and the lack of methods for reliable removal of palladium traces from the final product. In addition to toxicity, the high cost of catalysts based on palladium, as well as another catalyst for pharmaceuticals, platinum, makes the use of copper nanoparticles economically and environmentally justified.

Here’s a link to and a citation for the paper,

Copper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesis by Nisha Kant Ojha, Grigory V. Zyryanov, Adinath Majee, Valery N. Charushin, Oleg N. Chupakhin, Sougata Santra. Coordination Chemistry Reviews Volume 353, 15 December 2017, Pages 1-57 https://doi.org/10.1016/j.ccr.2017.10.004

This paper is behind a paywall.

Is technology taking our jobs? (a Women in Communications and Technology, BC Chapter event) and Brave New Work in Vancouver (Canada)

Awkwardly named as it is, the Women in Communications and Technology BC Chapter (WCTBC) has been reinvigorated after a moribund period (from a Feb. 21, 2018 posting by Rebecca Bollwitt for the Miss 604 blog),

There’s an exciting new organization and event series coming to Vancouver, which will aim to connect, inspire, and advance women in the communications and technology industries. I’m honoured to be on the Board of Directors for the newly rebooted Women in Communications and Technology, BC Chapter (“WCTBC”) and we’re ready to announce our first event!

Women in Debate: Is Technology Taking Our Jobs?

When: Tuesday, March 6, 2018 at 5:30pm
Where: BLG – 200 Burrard, 1200 Waterfront Centre, Vancouver
Tickets: Register online today. The cost is $25 for WCT members and $35 for non-members.

Automation, driven by technological progress, has been expanding for the past several decades. As the pace of development increases, so has the urgency in the debate about the potential effects of automation on jobs, employment, and human activity. Will new technology spawn mass unemployment, as the robots take jobs away from humans? Or is this part of a cycle that predates even the Industrial Revolution in which some jobs will become obsolete, while new jobs will be created?

Debaters:
Christin Wiedemann – Co-CEO, PQA Testing
Kathy Gibson – President, Catchy Consulting
Laura Sukorokoff – Senior Trainer & Communications, Hyperwallet
Sally Whitehead – Global Director, Sophos

Based on the Oxford style debates popularized by the podcast ‘Intelligence Squared’, the BC chapter of Women in Communications and Technology brings you Women in Debate: Is Technology Taking Our Jobs?

For anyone not familiar with “Intelligence Squared,”  there’s this from their About webpage,

ntelligence Squared is the world’s premier forum for debate and intelligent discussion. Live and online we take you to the heart of the issues that matter, in the company of some of the world’s sharpest minds and most exciting orators.

Intelligence Squared Live

Our events have captured the imagination of public audiences for more than a decade, welcoming the biggest names in politics, journalism and the arts. Our celebrated list of speakers includes President Jimmy Carter, Stephen Fry, Patti Smith, Richard Dawkins, Sean Penn, Marina Abramovic, Werner Herzog, Terry Gilliam, Anne Marie Slaughter, Reverend Jesse Jackson, Mary Beard, Yuval Noah Harari, Jonathan Franzen, Salman Rushdie, Eric Schmidt, Richard Branson, Professor Brian Cox, Nate Silver, Umberto Eco, Martin Amis and Grayson Perry.

Further digging into WCTBC unearthed this story about the reasons for its ‘reboot’, from the Who we are / Regional Chapters / British Columbia webpage,

“Earlier this month [October 2017?], Christin Wiedemann and Briana Sim, co-Chairs of the BC Chapter of WCT, attended a Women in IoT [Internet of Things] event in Vancouver. The event was organized by the GE Women’s Network and TELUS Connections, with WCT as an event partner. The event sold out after only two days, and close to 200 women attended.

Five female panelists representing different backgrounds and industries talked about the impact IoT is having on our lives today, and how they think IoT fits into the future of the technology landscape. Christin facilitated the Q&A portion of the event, and had an opportunity to share that the BC chapter is rebooting and hopes to launch a kickoff event later in November”

You can find a summary of the event here (http://gereports.ca/theres-lots-room-us-top-insights-five-canadas-top-women-business-leaders-iot/#), and you can also check out the Storify (https://storify.com/cwiedemann/women-in-iot​).”

– October 6th, 2017

Simon Fraser University’s Brave New Work

Coincidentally or not, there’s a major series of events being offered by Simon Fraser University’s (SFU; located in Vancouver, British Columbia, Canada) Public Square Programme in their 2018 Community Summit Series titled: Brave New Work; How can we thrive in the changing world of work? which takes place February 26, 2018 to March 7, 2018.

There’s not a single mention (!!!!!) of Brave New World (by Aldous Huxley) in what is clearly word play based on this man’s book.

From the 2018 Community Summit: Brave New Work webpage on the SFU website (Note: Links have been removed),

How can we thrive in the changing world of work?

The 2018 Community Summit, Brave New Work, invites us to consider how we can all thrive in the changing world of work.

Technological growth is happening at an unprecedented rate and scale, and it is fundamentally altering the way we organize and value work. The work we do (and how we do it) is changing. One of the biggest challenges in effectively responding to this new world of work is creating a shared understanding of the issues at play and how they intersect. Individuals, businesses, governments, educational institutions, and civil society must collaborate to construct the future we want.

The future of work is here, but it’s still ours to define. From February 26th to March 7th, we will convene diverse communities through a range of events and activities to provoke thinking and encourage solution-finding. We hope you’ll join us.

The New World of Work: Thriving or Surviving?

As part of its 2018 Community Summit, Brave New Work, SFU Public Square is proud to present, in partnership with Vancity, an evening with Van Jones and Anne-Marie Slaughter, moderated by CBC’s Laura Lynch at the Queen Elizabeth Theatre.

Van Jones and Anne-Marie Slaughter, two leading commentators on the American economy, will discuss the role that citizens, governments and civil society can play in shaping the future of work. They will explore the challenges ahead, as well as how these challenges might be addressed through green jobs, emergent industries, education and public policy.

Join us for an important conversation about how the future of work can be made to work for all of us.

Are you a member of Vancity? As one of the many perks of being a Vancity member, you have access to a free ticket to attend the event. For your free ticket, please visit Vancity for more information. There are a limited number of seats reserved for Vancity members, so we encourage you to register early.

Tickets are now on sale, get yours today!

Future of Work in Canada: Emerging Trends and Opportunities

What are some of the trends currently defining the new world of work in Canada, and what does our future look like? What opportunities can be seized to build more competitive, prosperous, and inclusive organizations? This mini-conference, presented in partnership with Deloitte Canada, will feature panel discussions and presentations by representatives from Deloitte, Brookfield Institute for Innovation & Entrepreneurship, Vancity, Futurpreneur, and many more.

Work in the 21st Century: Innovations in Research

Research doesn’t just live in libraries and academic papers; it has a profound impact on our day to day lives. Work in the 21st Century is a dynamic evening that showcases the SFU researchers and entrepreneurs who are leading the way in making innovative impacts in the new world of work.

Basic Income

This lecture will examine the question of basic income (BI). A neoliberal version of BI is being considered and even developed by a number of governments and institutions of global capitalism. This form of BI could enhance the supply of low wage precarious workers, by offering a public subsidy to employers, paid for by cuts to others areas of social provision.

ReframeWork

ReframeWork is a national gathering of leading thinkers and innovators on the topic of Future of Work. We will explore how Canada can lead in forming new systems for good work and identify the richest areas of opportunity for solution-building that affects broader change.

The Urban Worker Project Skillshare

The Urban Worker Project Skillshare is a day-long gathering, bringing together over 150 independent workers to lean on each other, learn from each other, get valuable expert advice, and build community. Join us!

SFU City Conversations: Making Visible the Invisible

Are outdated and stereotypical gender roles contributing to the invisible workload? What is the invisible workload anyway? Don’t miss this special edition of SFU City Conversations on intersectionality and invisible labour, presented in partnership with the Simon Fraser Student Society Women’s Centre.

Climate of Work: How Does Climate Change Affect the Future of Work

What does our changing climate have to do with the future of work? Join Embark as they explore the ways our climate impacts different industries such as planning, communications or entrepreneurship.

Symposium: Art, Labour, and the Future of Work

One of the key distinguishing features of Western modernity is that the activity of labour has always been at the heart of our self-understanding. Work defines who we are. But what might we do in a world without work? Join SFU’s Institute for the Humanities for a symposium on art, aesthetics, and self-understanding.

Worker Writers and the Poetics of Labour

If you gave a worker a pen, what would they write? What stories would they tell, and what experiences might they share? Hear poetry about what it is to work in the 21st century directly from participants of the Worker Writers School at this free public poetry reading.

Creating a Diverse and Resilient Economy in Metro Vancouver

This panel conversation event will focus on the future of employment in Metro Vancouver, and planning for the employment lands that support the regional economy. What are the trends and issues related to employment in various sectors in Metro Vancouver, and how does land use planning, regulation, and market demand affect the future of work regionally?

Preparing Students for the Future World of Work

This event, hosted by CACEE Canada West and SFU Career and Volunteer Services, will feature presentations and discussions on how post-secondary institutions can prepare students for the future of work.

Work and Purpose Later in Life

How is the changing world of work affecting older adults? And what role should work play in our lives, anyway? This special Philosophers’ Cafe will address questions of retirement, purpose, and work for older adults.

Beyond Bitcoin: Blockchain and the Future of Work

Blockchain technology is making headlines. Enthusiastic or skeptic, the focus of this dialogue will be to better understand key concepts and to explore the wide-ranging applications of distributed ledgers and the implications for business here in BC and in the global economy.

Building Your Resilience

Being a university student can be stressful. This interactive event will share key strategies for enhancing your resilience and well-being, that will support your success now and in your future career.

We may not be working because of robots (no mention of automation in the SFU descriptions?) but we sure will talk about work-related topics. Sarcasm aside, it’s good to see this interest in work and in public discussion although I’m deeply puzzled by SFU’s decision to seemingly ignore technology, except for blockchain. Thank goodness for WCTBC. At any rate, I’m often somewhat envious of what goes on elsewhere so it’s nice to see this level of excitement and effort here in Vancouver.

US National Nanotechnology Initiative publishes 2018 US President’s 2018 budget request

The US National Nanotechnology Initiative has made its budget request for 2018 according to a Dec. 5, 2017 anouncement by Lynn L. Bergeson and Carla Hutton at the Nano and Other Emerging Chemical Technologies blog on the JD Supra website (Note: A link has been removed),

On November 30, 2017, the National Nanotechnology Initiative (NNI) published a supplement to the President’s 2018 budget.  The supplement also serves as NNI’s annual report and summarizes the progress made in achieving NNI’s goals, the research and development (R&D) activities and plans of the participating agencies, and the agency investments in each program component area.  The President’s 2018 Budget requests $1.2 billion for the NNI, “a continued investment in support of innovation promoting America’s competitiveness, economic growth, and national security.”  The NNI investments proposed for 2018 reflect an emphasis on broad, fundamental research in nanoscience to provide a continuing pipeline of new discoveries that will enable future transformative commercial products and services.  …

The November 30, 2017 NNI Supplement to the President’s 2018 Budget can be found here. Click on the download button (or go here) for the full supplement which includes explanations for the initialisms, e.g., PCA, STIR, etc. and sections such as this about key points,

Key Points about the 2016–2018 NNI Investments

• Reductions in overall NNI investments for 2018 relative to 2016–2017 and previous years are consistent with the goal of the President’s 2018 Budget to prioritize Federal resources on areas that industry is not likely to support, over later-stage applied research and development that the private sector is better equipped to pursue.

• The actual NNI investments reported by the participating agencies for 2016 ($1.56 billion) are significantly larger than 2016 estimated investments published in the 2017 Budget ($1.43 billion) and 2016 requested investments published in the 2016 Budget ($1.50 billion). This change is due largely to the fact that an increasing proportion of agencies’ nanotechnology investments are coming from “core” R&D programs, where the high success rate of nanotechnology-related proposals cannot be anticipated in advance.

• Total funding for PCA 1, Nanotechnology Signature Initiatives and Grand Challenges, for 2018 (nearly $200 million, representing over 16% of the NNI total) reflects the emphasis on focused investments in R&D that advances interagency cooperation and public/private partnerships in support of national priorities, as a key part of the overall NNI funding strategy.

• The NNI’s Nanotechnology-Inspired Grand Challenge for Future Computing is a new investment category in the President’s 2018 Budget, included for the first time under PCA 1. This challenge helps to address renewed international competition for U.S. leadership in semiconductor manufacturing and downstream information technology industries. For 2016, agencies are reporting over $140 million in investments under the NNI budget crosscut (including related research under the Nanoelectronics NSI) in this sector, which is critical for both national security and economic competitiveness.

• The increase in the percentage of total NNI investments in PCA 2, Foundational Research (from 36% in 2016 to nearly 40% in the 2018 Budget) reflects the Budget’s focus on supporting early-stage R&D, and is consistent with calls by NNI advisory bodies to maintain a pipeline of basic research that will lead to the innovations of the future.

• Proportional NNI investments in PCA 3 (Nanotechnology-Enabled Applications, Devices, and Systems) hold steady at about 24% of the total NNI investments for 2016–2018, down slightly from 25% in 2015.

• NNI agencies continue to provide consistent, proportional funding for PCA 4 (Research Infrastructure and Instrumentation) for 2016–2018, at 15–16% of the NNI total. The 2018 request ($179 million, representing about 15% of the NNI total investment) includes sustained support for NSF’s National Nanotechnology Coordinated Infrastructure network of university-based nanotechnology user facilities. The President’s 2018 Budget for DOE requests continued support for three of the original five Nanoscale Science Research Centers. PCA 4 also includes research to develop novel or improvedinstrumentation, which is critical to continued progress in nanotechnology and to maintain U.S. competitiveness internationally.

• PCA 5 (Environment, Health, and Safety—EHS) investments are a key element of the NNI’s strategy to ensure responsible development of nanotechnology. For 2016–2018, the proportional research investments reported under PCA 5 (see Appendix A for definitions) are approximately 6% of the NNI total for 2016 and 2017, and 5.5% in the 2018 Budget. In addition to the PCA 5 investments, some research reported under other PCAs (e.g., PCA 1 and PCA 4) also contributes to the overall EHS research portfolio.

• The return of the Department of Justice’s National Institute of Justice (NIJ) to the NNI budget crosscut in the 2018 President’s Budget is another example of where nanotechnology innovations initially funded by basic research agencies are now coming to fruition in R&D programs focused on applications, devices, and systems that directly contribute to national priorities.

• Investments in SBIR and STTR funding by the participating agencies, reported outside of the formal NNI funding crosscut tabulated in the budget tables shown above, play a critical role in transitioning nanotechnology innovations into products for commercial and public benefit (NNI Goal 2), as discussed below. [pp. 14-17 (print) pp. 22-25 [PDF)]

Happy reading!

2016 Nobel prize winner introduces anti-aging skincare line

When last mentioned here (Oct. 6, 2016 posting), J. Fraser Stoddart, along with his French colleague Jean-Pierre Sauvage and his Dutch colleague Bernard “Ben” Feringa, had just been awarded a 2016 Nobel Prize for Chemistry for developing molecular machines. In what seems like an unusual career move, Stoddart has recently introduced a skin care line. From a December 5, 2017 article by Marc S. Reisch for Chemical and Engineering News (c&en), Note: A link has been removed,

In 2016, J. Fraser Stoddart won the Nobel Prize in Chemistry for his part in designing a molecular machine. Now as chief technology officer and co-founder of nanotechnology firm PanaceaNano, he has introduced the “Noble” line of antiaging cosmetics including a $524 formula described as an “anti-wrinkle repair” night cream. The firm says the cream contains patented Nobel Prize-winning “organic nano-cubes” loaded with ingredients that reverse skin damage and reduce the appearance of wrinkles.

Other prize-winning chemists have founded companies, but Stoddart’s backing of the anti-aging cosmetic line takes the promotion of a new company by an award-winning scientist to the next level.

The nano-cubes are made of carbohydrate molecules known as cyclodextrins. The cubes, of various sizes and shapes, release ingredients such as vitamins and peptides onto the skin “at predefined times with molecular precision,” according to the Noble skin care website. PanaceaNano co-founder Youssry Botros, former nanotechnology research director at Intel, contends that the metering technology makes the product line “far superior to comparable products in the market today,” However, the nanocubes aren’t molecular machines, for which Stoddart won his Nobel prize.

A November 27, 2017 PanaceaNano news release on Cision PR Newswire provides more details about the skin care line,

The NOBLE skin care breakthrough technology is based on patented Organic Nano-Cube (ONC) molecules, which are made up of hollow cubes that work as molecular reservoirs to store and release skin care active ingredients in an extended release formulation directly onto the skin in a controlled manner, allowing for continuous skin revitalization, renewal and repair over a longer period of time.

Unlike other products, with ONC, you have more than just extended release. ONC molecules provide tunable release profiles that are engineered for delayed and multiple release of different ingredients that each have their own characteristics. ONC molecules are controllable at a smaller nano-scale to better control the individual molecular ingredients. NOBLE is “Skin Care with Molecular Precision” because ONC molecules really control the release of active skin care ingredients at the molecular level, instead of just putting the ingredients in a macroscopic slow-release matrix like other products in the market today.

“This molecular precision enables the NOBLE luxury skin care product line to reduce visible signs of aging more effectively by precisely releasing the anti-aging ingredients for over a longer period. Because of the revolutionary ONC technology, NOBLE has a much longer duration of anti-aging benefit with continuous and steady efficacy, making it far superior to comparable products in the market today,” says Dr. Youssry Botros, PanaceaNano Co-founder and CEO. “Other skin care brands have immediate release formulations whose active ingredients are often depleted immediately. NOBLE products are clinically proven to reverse and slow down skin aging.”

NOBLE skin care products will immediately start working on the skin. Most consumers notice relatively visible results within two weeks, while significant results are observed by most consumers after 10 to 12 weeks.

“It is an exciting moment to witness the birth of commercial products that improve the quality of life of people based on renewable, safe, organic, bio-degradable functional nanomaterials,” stated Sir Fraser.

For additional information, please go to www.noble-skincare.com

Noble/Nobel? Was someone indulging in word play?

According to the Noble skin care product page, costs range from $249. for .5 oz of anti-aging eye cream to $524 for 1.7 oz of anti-wrinkle repair cream, presumably in US dollars. Note: I am not endorsing this product as I have not used it.

For anyone interested in the parent company, PanaceaNano can be found here.

University of Washington (state) is accelerating nanoscale research with Institute for Nano-Engineered Systems

A December 5, 2017 news item on Nanowerk announced a new research institute at the University of Washington (state),

The University of Washington [UW} has launched a new institute aimed at accelerating research at the nanoscale: the Institute for Nano-Engineered Systems, or NanoES. Housed in a new, multimillion-dollar facility on the UW’s Seattle campus, the institute will pursue impactful advancements in a variety of disciplines — including energy, materials science, computation and medicine. Yet these advancements will be at a technological scale a thousand times smaller than the width of a human hair.

The institute was launched at a reception Dec. 4 [2017] at its headquarters in the $87.8-million Nano Engineering and Sciences Building. During the event, speakers including UW officials and NanoES partners celebrated the NanoES mission to capitalize on the university’s strong record of research at the nanoscale and engage partners in industry at the onset of new projects.

A December 5, 2017 UW news release, which originated the news item, somewhat clarifies the declarations in the two excerpted paragraphs in the above,

The vision of the NanoES, which is part of the UW’s College of Engineering, is to act as a magnet for researchers in nanoscale science and engineering, with a focus on enabling industry partnership and entrepreneurship at the earliest stages of research projects. According to Karl Böhringer, director of the NanoES and a UW professor of electrical engineering and bioengineering, this unique approach will hasten the development of solutions to the field’s most pressing challenges: the manufacturing of scalable, high-yield nano-engineered systems for applications in information processing, energy, health and interconnected life.

“The University of Washington is well known for its expertise in nanoscale materials, processing, physics and biology — as well as its cutting-edge nanofabrication, characterization and testing facilities,” said Böhringer, who stepped down as director of the UW-based Washington Nanofabrication Facility to lead the NanoES. “NanoES will build on these strengths, bringing together people, tools and opportunities to develop nanoscale devices and systems.”

The centerpiece of the NanoES is its headquarters, the Nano Engineering and Sciences Building. The building houses 90,300 square feet of research and learning space, and was funded largely by the College of Engineering and Sound Transit. It contains an active learning classroom, a teaching laboratory and a 3,000-square-foot common area designed expressly to promote the sharing and exchanging of ideas. The remainder includes “incubator-style” office space and more than 40,000 square feet of flexible multipurpose laboratory and instrumentation space. The building’s location and design elements are intended to limit vibrations and electromagnetic interference so it can house sensitive experiments.

NanoES will house research in nanotechnology fields that hold promise for high impact, such as:

  • Augmented humanity, which includes technology to both aid and replace human capability in a way that joins user and machine as one – and foresees portable, wearable, implantable and networked technology for applications such as personalized medical care, among others.
  • Integrated photonics, which ranges from single-photon sensors for health care diagnostic tests to large-scale, integrated networks of photonic devices.
  • Scalable nanomanufacturing, which aims to develop low-cost, high-volume manufacturing processes. These would translate device prototypes constructed in research laboratories into system- and network-level nanomanufacturing methods for applications ranging from the 3-D printing of cell and tissue scaffolds to ultrathin solar cells.

A ribbon cutting ceremony.

Cutting the ribbon for the NanoES on Dec. 4. Left-to-right: Karl Böhringer, director of the NanoES and a UW professor of electrical engineering and bioengineering; Nena Golubovic, physical sciences director for IP Group; Mike Bragg, Dean of the UW College of Engineering; Jevne Micheau-Cunningham, deputy director of the NanoES.Kathryn Sauber/University of Washington

Collaborations with other UW-based institutions will provide additional resources for the NanoES. Endeavors in scalable nanomanufacturing, for example, will rely on the roll-to-roll processing facility at the UW Clean Energy Institute‘s Washington Clean Energy Testbeds or on advanced surface characterization capabilities at the Molecular Analysis Facility. In addition, the Washington Nanofabrication Facility recently completed a three-year, $37 million upgrade to raise it to an ISO Class 5 nanofabrication facility.

UW faculty and outside collaborators will build new research programs in the Nano Engineering and Sciences Building. Eric Klavins, a UW professor of electrical engineering, recently moved part of his synthetic biology research team to the building, adjacent to his collaborators in the Molecular Engineering & Sciences Institute and the Institute for Protein Design.

“We are extremely excited about the interdisciplinary and collaborative potential of the new space,” said Klavins.

The NanoES also has already produced its first spin-out company, Tunoptix, which was co-founded by Böhringer and recently received startup funding from IP Group, a U.K.-based venture capital firm.

“IP Group is very excited to work with the University of Washington,” said Nena Golubovic, physical sciences director for IP Group. “We are looking forward to the new collaborations and developments in science and technology that will grow from this new partnership.”

A woman speaking at a podium.

Nena Golubovic, physical sciences director for IP Group, delivering remarks at the Dec. 4 opening of NanoES.Kathryn Sauber/University of Washington

“We are eager to work with our partners at the IP Group to bring our technology to the market, and we appreciate their vision and investment in the NanoES Integrated Photonics Initiative,” said Tunoptix entrepreneurial lead Mike Robinson. “NanoES was the ideal environment in which to start our company.”

The NanoES leaders hope to forge similar partnerships with researchers, investors and industry leaders to develop technologies for portable, wearable, implantable and networked nanotechnologies for personalized medical care, a more efficient interconnected life and interconnected mobility. In addition to expertise, personnel and state-of-the-art research space and equipment, the NanoES will provide training, research support and key connections to capital and corporate partners.

“We believe this unique approach is the best way to drive innovations from idea to fabrication to scale-up and testing,” said Böhringer. “Some of the most promising solutions to these huge challenges are rooted in nanotechnology.”

The NanoES is supported by funds from the College of Engineering and the National Science Foundation, as well as capital investments from investors and industry partners.

You can find out more about Nano ES here.