Category Archives: manufacturing

Rafts! a game for your inner genetic engineer

Earlier this week, RaftsTheGame (@TheRaftsGame) popped up on my twitter feed, which was excellent timing since it’s getting close to Christmas in a year (2020) when I imagine a lot of people may be home and inclined to play games.

The people (rafts4biotech) who produced Rafts The Game (also called Rafts!) are involved in a research project funded by the European Union’s Horizon 2020 programme,

Create the bacterium of your dreams

Have you ever wondered what it would be like to be a genetic engineer? Now’s your chance to find out! Rafts! is a card game in which your aim is to design a bacterium while trying to overcome the challenges of research work.

If you are a researcher, look no further – Rafts! enables you to finally share your academic struggles with those friends who don’t have a clue of what you do!


In Rafts! you race to become the first scientist to create a bacterium that can do incredible things: cleaning an oil spill, detecting toxic compounds, producing blood for donations… Sounds like science fiction? More like a regular day at the lab!

But don’t get carried away – nobody said conducting research was easy! Hard work alone isn’t enough if you don’t have the right genetic instructions as well as a combination of money, time as well as food for your bacterium. You’ll have to collect all of these resources to finish the masterpiece that is your bacterium.

In this laboratory people play dirty, so don’t forget to keep an eye on your colleagues – they are all trying to achieve their objectives, and sometimes you will compete for the same resources. Don’t hesitate to strike back!


There are three types of cards in Rafts!: action cards help you gather the resource cards that you will need to achieve the goal in your objective card. Bring your mouse on top of a card to know what it can do!


Ready to become the biotech wizard you’ve always wanted to be? You’re just a click away from building the bacterium of a lifetime!

Download Rafts! for free and print it yourself – or let your local print shop do it for you:



Order a ready-made Rafts! deck to your doorsteps – by clicking on the link we direct you to the card shop where you can finish your order:


Here’s what the cards look like,

[downloaded from]

The rules of the game are here.

For anyone curious about the source for the game, here’s a bit about rafts4biotech, from the homepage,

Engineering bacterial lipid rafts to optimise industrial processes


Bacteria are used in the biotechnology industry to produce a wide range of valuable compounds. However, the performance of these microorganisms in the demanding industrial conditions is limited by the toxicity of some compounds and the complex metabolic interactions that occur within the bacterial cells.


Generating new synthetic microorganisms that will solve productivity hurdles and yield a great variety of economy-value compounds. These modified strains will be used as standardised microbial chassis platforms to fit industry needs.


The R4B solution relies on confining the production of compounds to specific areas of the microbe’s membrane called lipid rafts.  This recently-discovered regions present an ideal setting that will avoid interferences with bacterial metabolism and viability.

Given that at least one of the COVID-19 vaccines (Pfizer-BioNTech?) is wrapped in lipid nanobodies and, now, with this mention of lipids, it seemed like a good idea (for me) to learn about lipids. Here’s what I found in the definition for lipid in The free Dictionary,

a group of substances comprising fatty, greasy, oily, and waxy compounds that are insoluble in water and soluble in nonpolar solvents, such as hexane, ether, and chloroform.

Let the games begin!

Boost single-walled carbon nantube (SWCNT) production

I’m fascinated by this image,

Caption: Skoltech researchers have investigated the procedure for catalyst delivery used in the most common method of carbon nanotube production, chemical vapor deposition (CVD), offering what they call a “simple and elegant” way to boost productivity and pave the way for cheaper and more accessible nanotube-based technology. Credit: Pavel Odinev/Skoltech

If I understand it correctly, getting the catalyst particles into a tighter, more uniform formation is what could lead to a boost in the production of single-walled carbon nanotubes (SWCNTs).

The work was announced in a Nov. 30, 2020 news item in Nanowerk,

Skoltech [Skolkovo Institute of Science and Technology; Russia] researchers have investigated the procedure for catalyst delivery used in the most common method of carbon nanotube production, chemical vapor deposition (CVD), offering what they call a “simple and elegant” way to boost productivity and pave the way for cheaper and more accessible nanotube-based technology.

A Nov. 30, 2020 Skolkovo Institute of Science and Technology (Skoltech) press release (also on EurekAlert but published on Dec. 1, 2020), which originated the news item, explains in detail,

Single-walled carbon nanotubes (SWCNT), tiny rolled sheets of graphene with a thickness of just one atom, hold huge promise when it comes to applications in materials science and electronics. That is the reason why so much effort is focused on perfecting the synthesis of SWCNTs; from physical methods, such as using laser beams to ablate a graphite target, all the way to the most common CVD approach, when metal catalyst particles are used to “strip” a carbon-containing gas of its carbon and grow the nanotubes on these particles.

“The road from raw materials to carbon nanotubes requires a fine balance between dozens of reactor parameters. The formation of carbon nanotubes is a tricky and complex process that has been studied for a long time, but still keeps many secrets,” explains Albert Nasibulin, a professor at Skoltech and an adjunct professor at the Department of Chemistry and Materials Science, Aalto University School of Chemical Engineering.

Various ways of enhancing catalyst activation, in order to produce more SWCNTs with the required properties, have already been suggested. Nasibulin and his colleagues focused on the injection procedure, namely on how to distribute ferrocene vapor (a commonly used catalyst precursor) within the reactor.

They grew their carbon nanotubes using the aerosol CVD approach, using carbon monoxide as a source of carbon, and monitored the synthesis productivity and SWCNT characteristics (such as their diameter) depending on the rate of catalyst injection and the concentration of CO2 (carbon dioxide; used as an agent for fine-tuning). Ultimately the researchers concluded that “injector flow rate adjustment could lead to a 9-fold increase in the synthesis productivity while preserving most of the SWCNT characteristics”, such as their diameter, the share of defective nanotubes, and film conductivity.

“Every technology is always about efficiency. When it comes to CVD production of nanotubes, the efficiency of the catalyst is usually out of sight. However, we see a great opportunity there and this work is only a first step towards an efficient technology,” Dmitry Krasnikov, senior research scientist at Skoltech and co-author of the paper, says.

Here’s a link to and a citation for the paper,

Activation of catalyst particles for single-walled carbon nanotube synthesis by Eldar M.Khabushev, Julia V. Kolodiazhnaia, Dmitry V. Krasnikov, Albert G. Nasibulin. Chemical Engineering Journal DOI: Available online 24 October 2020, 127475

This paper is behind a paywall.

OCSiAl becomes largest European supplier of single-walled carbon nanotubes (SWCNTs)

It’s time I posted news about OCSiAl as it’s been about five years since they were last mentioned here. An April 24, 2020 news item on AzoNano proclaims a new status for the company,

As from [sic] April 2020, OCSiAl is able to commercialize up to 100 tonnes annually of its TUBALL™ single wall carbon nanotubes [single-walled carbon nanotubes or SWCNTs] in Europe thanks to the company’s upgraded dossier under the EU’s [European Union’s] “Registration, Evaluation, Authorization and Restriction of Chemicals” (REACH) legislation, being additionally compliant with the new Annexes on nanoforms. OCSiAl will continue to expand markets for nanotubes and widen industrial applications by scaling-up its permitted volume in Australia and Canada in 2020, pending approval by the authorities.

An April 23, 2020 OCSiAl press release, which originated the news item, provides more details about the company and its customers in ‘marketingese’ (marketing language),

OCSiAl is now the only company in Europe able to commercialize up to 100 tonnes of single wall carbon nanotubes, also known as graphene nanotubes. This step allows the company to boost its presence in the region and to meet the growing market demand for industrial volumes of graphene nanotubes. The company’s current portfolio includes over 1,600 customers worldwide, with China and Europe as the two most rapidly expanding markets for nanotube applications in transportation, electronics, construction, infrastructure, renewable energy, power sources, sports equipment, 3D-printing, textiles, sensors and many more.

OCSiAl plays a leading role in improving the accessibility of information on the nature of graphene nanotubes and in forming the principles of their safe handling – the company has so far initiated 16 studies in these fields, including those required by the revised REACH annex. TUBALL nanotubes demonstrate no skin irritation, corrosion or sensitization, no mutagenic effect, and no adverse effect on reproductive toxicity. In addition, ecotoxicity studies have shown no toxic effect on Daphnia or algae. The typical exposure values of respirable fraction of TUBALL in the workplace is much less than 5% of the Recommended Exposure Limits (REL) as per NIOSH in the USA, which is of practical importance for manufacturers working with nanotubes. And end users can also be reassured that these studies have shown that no TUBALL nanotubes are released during utilization of products made with nanoaugmented materials. All these findings reflect the unique nature and morphology of TUBALL graphene nanotubes.

OCSiAl continues to accelerate the acceptance of this unique material in various markets by supplying high-quality nanotubes at an economically feasible price and in industrial volumes. TUBALL is regulated by the Environmental Protection Agency (EPA) in the US, where it is also allowed to be commercialized in industrial volumes. The company’s near-term plans include scaling-up the permitted volume of industrial commercialization of graphene nanotubes in Australia and Canada.

The company appears to be trying to rebrand carbon nanotubes as graphene nanotubes. It can be done (e.g., facial tissue instead of Kleenex or photocopy instead of Xerox) but it can take a long time and, after a brief search (May 13, 2020), I was not able to find any other reference to ‘graphene nanotubes’ online.

Between the two of them, OCSiAl’s Wikipedia entry and the company’s Team webpage (scroll down past the smiling faces), you can find some company history.

Graphene from gum trees

Caption: Eucalyptus bark extract has never been used to synthesise graphene sheets before. Courtesy: RMIT University

It’s been quite educational reading a June 24, 2019 news item on Nanowerk about deriving graphene from Eucalyptus bark (Note: Links have been removed),

Graphene is the thinnest and strongest material known to humans. It’s also flexible, transparent and conducts heat and electricity 10 times better than copper, making it ideal for anything from flexible nanoelectronics to better fuel cells.

The new approach by researchers from RMIT University (Australia) and the National Institute of Technology, Warangal (India), uses Eucalyptus bark extract and is cheaper and more sustainable than current synthesis methods (ACS Sustainable Chemistry & Engineering, “Novel and Highly Efficient Strategy for the Green Synthesis of Soluble Graphene by Aqueous Polyphenol Extracts of Eucalyptus Bark and Its Applications in High-Performance Supercapacitors”).

A June 24, 2019 RMIT University news release (also on EurekAlert), which originated the news item, provides a little more detail,

RMIT lead researcher, Distinguished Professor Suresh Bhargava, said the new method could reduce the cost of production from $USD100 per gram to a staggering $USD0.5 per gram.

“Eucalyptus bark extract has never been used to synthesise graphene sheets before and we are thrilled to find that it not only works, it’s in fact a superior method, both in terms of safety and overall cost,” said Bhargava.

“Our approach could bring down the cost of making graphene from around $USD100 per gram to just 50 cents, increasing it availability to industries globally and enabling the development of an array of vital new technologies.”

Graphene’s distinctive features make it a transformative material that could be used in the development of flexible electronics, more powerful computer chips and better solar panels, water filters and bio-sensors.

Professor Vishnu Shanker from the National Institute of Technology, Warangal, said the ‘green’ chemistry avoided the use of toxic reagents, potentially opening the door to the application of graphene not only for electronic devices but also biocompatible materials.

“Working collaboratively with RMIT’s Centre for Advanced Materials and Industrial Chemistry we’re harnessing the power of collective intelligence to make these discoveries,” he said.

A novel approach to graphene synthesis:

Chemical reduction is the most common method for synthesising graphene oxide as it allows for the production of graphene at a low cost in bulk quantities.

This method however relies on reducing agents that are dangerous to both people and the environment.

When tested in the application of a supercapacitor, the ‘green’ graphene produced using this method matched the quality and performance characteristics of traditionally-produced graphene without the toxic reagents.

Bhargava said the abundance of eucalyptus trees in Australia made it a cheap and accessible resource for producing graphene locally.

“Graphene is a remarkable material with great potential in many applications due to its chemical and physical properties and there’s a growing demand for economical and environmentally friendly large-scale production,” he said.

Here’s a link to and a citation for the paper,

Novel and Highly Efficient Strategy for the Green Synthesis of Soluble Graphene by Aqueous Polyphenol Extracts of Eucalyptus Bark and Its Applications in High-Performance Supercapacitors by Saikumar ManchalaV. S. R. K. Tandava, Deshetti Jampaiah, Suresh K. Bhargava, Vishnu Shanker. ACS Sustainable Chem. Eng.2019XXXXXXXXXX-XXX DOI: Publication Date:June 13, 2019

Copyright © 2019 American Chemical Society

This paper is behind a paywall.

Vitamin C helps gold nanowires grow

This research gives new meaning to ‘Take your vitamin C’ as can be seen in a February 19, 2019 news item on Nanowerk,

A boost of vitamin C helped Rice University scientists turn small gold nanorods into fine gold nanowires.

Common, mild ascorbic acid is the not-so-secret sauce that helped the Rice lab of chemist Eugene Zubarev grow pure batches of nanowires from stumpy nanorods without the drawbacks of previous techniques.

“There’s no novelty per se in using vitamin C to make gold nanostructures because there are many previous examples,” Zubarev said. “But the slow and controlled reduction achieved by vitamin C is surprisingly suitable for this type of chemistry in producing extra-long nanowires.”

A February 19, 2019 Rice University news release (also on EurekAlert), which originated the news item, provides more technical detail about the research

The Rice lab’s nanorods are about 25 nanometers thick at the start of the process – and remain that way while their length grows to become long nanowires. Above 1,000 nanometers in length, the objects are considered nanowires, and that matters. The wires’ aspect ratio – length over width – dictates how they absorb and emit light and how they conduct electrons. Combined with gold’s inherent metallic properties, that could enhance their value for sensing, diagnostic, imaging and therapeutic applications.

Zubarev and lead author Bishnu Khanal, a Rice chemistry alumnus, succeeded in making their particles go far beyond the transition from nanorod to nanowire, theoretically to unlimited length.

The researchers also showed the process is fully controllable and reversible. That makes it possible to produce nanowires of any desired length, and thus the desired configuration for electronic or light-manipulating applications, especially those that involve plasmons, the light-triggered oscillation of electrons on a metal’s surface.

The nanowires’ plasmonic response can be tuned to emit light from visible to infrared and theoretically far beyond, depending on their aspect ratios.

The process is slow, so it takes hours to grow a micron-long nanowire. “In this paper, we only reported structures up to 4 to 5 microns in length,” Zubarev said. “But we’re working to make much longer nanowires.”

The growth process only appeared to work with pentahedrally twinned gold nanorods, which contain five linked crystals. These five-sided rods — “Think of a pencil, but with five sides instead of six,” Zubarev said — are stable along the flat surfaces, but not at the tips.

“The tips also have five faces, but they have a different arrangement of atoms,” he said. “The energy of those atoms is slightly lower, and when new atoms are deposited there, they don’t migrate anywhere else.”

That keeps the growing wires from gaining girth. Every added atom increases the wire’s length, and thus the aspect ratio.

The nanorods’ reactive tips get help from a surfactant, CTAB, that covers the flat surfaces of nanorods. “The surfactant forms a very dense, tight bilayer on the sides, but it cannot cover the tips effectively,” Zubarev said.

That leaves the tips open to an oxidation or reduction reaction. The ascorbic acid provides electrons that combine with gold ions and settle at the tips in the form of gold atoms. And unlike carbon nanotubes in a solution that easily aggregate, the nanowires keep their distance from one another.

“The most valuable feature is that it is truly one-dimensional elongation of nanorods to nanowires,” Zubarev said. “It does not change the diameter, so in principal we can take small rods with an aspect ratio of maybe two or three and elongate them to 100 times the length.”
He said the process should apply to other metal nanorods, including silver.

Here’s a link to and a citation for the paper,

Chemical Transformation of Nanorods to Nanowires: Reversible Growth and Dissolution of Anisotropic Gold Nanostructures by Bishnu P. Khanal and Eugene R. Zubarev. ACS Nano, 2019, 13 (2), pp 2370–2378 DOI: 10.1021/acsnano.8b09203 Publication Date (Web): February 12, 2019

Copyright © 2019 American Chemical Society

This paper is behind a paywall. Below you’ll find an image fo what I believe to be the vitamin C-enhanced gold nanowires.

Caption: Gold nanowires grown in the Rice University lab of chemist Eugene Zubarev promise to provide tunable plasmonic properties for optical and electronic applications. The wires can be controllably grown from nanorods, or reduced. Credit: Zubarev Research Group/Rice University

Altered virus spins gold into beads

They’re not calling this synthetic biology but I’ m pretty sure that altering a virus gene so the virus can spin gold (Rumpelstiltskin anyone?) qualifies. From an August 24, 2018 news item on ScienceDaily,

The race is on to find manufacturing techniques capable of arranging molecular and nanoscale objects with precision.

Engineers at the University of California, Riverside, have altered a virus to arrange gold atoms into spheroids measuring a few nanometers in diameter. The finding could make production of some electronic components cheaper, easier, and faster.

An August 23, 2018 University of California at Riverside (UCR) news release (also on EurekAlett) by Holly Ober, which originated the news item, adds detail,

“Nature has been assembling complex, highly organized nanostructures for millennia with precision and specificity far superior to the most advanced technological approaches,” said Elaine Haberer, a professor of electrical and computer engineering in UCR’s Marlan and Rosemary Bourns College of Engineering and senior author of the paper describing the breakthrough. “By understanding and harnessing these capabilities, this extraordinary nanoscale precision can be used to tailor and build highly advanced materials with previously unattainable performance.”

Viruses exist in a multitude of shapes and contain a wide range of receptors that bind to molecules. Genetically modifying the receptors to bind to ions of metals used in electronics causes these ions to “stick” to the virus, creating an object of the same size and shape. This procedure has been used to produce nanostructures used in battery electrodes, supercapacitors, sensors, biomedical tools, photocatalytic materials, and photovoltaics.

The virus’ natural shape has limited the range of possible metal shapes. Most viruses can change volume under different scenarios, but resist the dramatic alterations to their basic architecture that would permit other forms.

The M13 bacteriophage, however, is more flexible. Bacteriophages are a type of virus that infects bacteria, in this case, gram-negative bacteria, such as Escherichia coli, which is ubiquitous in the digestive tracts of humans and animals. M13 bacteriophages genetically modified to bind with gold are usually used to form long, golden nanowires.

Studies of the infection process of the M13 bacteriophage have shown the virus can be converted to a spheroid upon interaction with water and chloroform. Yet, until now, the M13 spheroid has been completely unexplored as a nanomaterial template.

Haberer’s group added a gold ion solution to M13 spheroids, creating gold nanobeads that are spiky and hollow.

“The novelty of our work lies in the optimization and demonstration of a viral template, which overcomes the geometric constraints associated with most other viruses,” Haberer said. “We used a simple conversion process to make the M13 virus synthesize inorganic spherical nanoshells tens of nanometers in diameter, as well as nanowires nearly 1 micron in length.”

The researchers are using the gold nanobeads to remove pollutants from wastewater through enhanced photocatalytic behavior.

The work enhances the utility of the M13 bacteriophage as a scaffold for nanomaterial synthesis. The researchers believe the M13 bacteriophage template transformation scheme described in the paper can be extended to related bacteriophages.

Here’s a link to and a citation for the paper,

M13 bacteriophage spheroids as scaffolds for directed synthesis of spiky gold nanostructures by Tam-Triet Ngo-Duc, Joshua M. Plank, Gongde Chen, Reed E. S. Harrison, Dimitrios Morikis, Haizhou Liu, and Elaine D. Haberer. Nanoscale, 2018,10, 13055-13063 DOI: 10.1039/C8NR03229G First published on 25 Jun 2018

This paper is behind a paywall.

For another example of genetic engineering and synthetic biology, see my July 18, 2018 posting: Genetic engineering: an eggplant in Bangladesh and a synthetic biology grant at Concordia University (Canada).

For anyone unfamiliar with the Rumpelstiltskin fairytale about spinning straw into gold, see its Wikipedida entry.

Researchers, manufacturers, and administrators need to consider shared quality control challenges to advance the nanoparticle manufacturing industry ‘

Manufacturing remains a bit of an issue where nanotechnology is concerned due to the difficulties of producing nanoparticles of a consistent size and type,

Electron micrograph showing gallium arsenide nanoparticles of varying shapes and sizes. Such heterogeneity [variation]  can increase costs and limit profits when making nanoparticles into products. A new NIST study recommends that researchers, manufacturers and administrators work together to solve this, and other common problems, in nanoparticle manufacturing. Credit: A. Demotiere, E. Shevchenko/Argonne National Laboratory

The US National Institute of Standards and Technology (NIST) has produced a paper focusing on how nanoparticle manufacturing might become more effective, from an August 22, 2018 news item on ScienceDaily,

Nanoparticle manufacturing, the production of material units less than 100 nanometers in size (100,000 times smaller than a marble), is proving the adage that “good things come in small packages.” Today’s engineered nanoparticles are integral components of everything from the quantum dot nanocrystals coloring the brilliant displays of state-of-the-art televisions to the miniscule bits of silver helping bandages protect against infection. However, commercial ventures seeking to profit from these tiny building blocks face quality control issues that, if unaddressed, can reduce efficiency, increase production costs and limit commercial impact of the products that incorporate them.

To help overcome these obstacles, the National Institute of Standards and Technology (NIST) and the nonprofit World Technology Evaluation Center (WTEC) advocate that nanoparticle researchers, manufacturers and administrators “connect the dots” by considering their shared challenges broadly and tackling them collectively rather than individually. This includes transferring knowledge across disciplines, coordinating actions between organizations and sharing resources to facilitate solutions.

The recommendations are presented in a new paper in the journal ACS Applied Nano Materials.

An August 22, 2018 NIST news release, which originated the news item, describes how the authors of the ACS [American Chemical Society) Applied Nano Materials paper developed their recommendations,

“We looked at the big picture of nanoparticle manufacturing to identify problems that are common for different materials, processes and applications,” said NIST physical scientist Samuel Stavis, lead author of the paper. “Solving these problems could advance the entire enterprise.”

The new paper provides a framework to better understand these issues. It is the culmination of a study initiated by a workshop organized by NIST that focused on the fundamental challenge of reducing or mitigating heterogeneity, the inadvertent variations in nanoparticle size, shape and other characteristics that occur during their manufacture.

“Heterogeneity can have significant consequences in nanoparticle manufacturing,” said NIST chemical engineer and co-author Jeffrey Fagan.

In their paper, the authors noted that the most profitable innovations in nanoparticle manufacturing minimize heterogeneity during the early stages of the operation, reducing the need for subsequent processing. This decreases waste, simplifies characterization and improves the integration of nanoparticles into products, all of which save money.

The authors illustrated the point by comparing the production of gold nanoparticles and carbon nanotubes. For gold, they stated, the initial synthesis costs can be high, but the similarity of the nanoparticles produced requires less purification and characterization. Therefore, they can be made into a variety of products, such as sensors, at relatively low costs.

In contrast, the more heterogeneous carbon nanotubes are less expensive to synthesize but require more processing to yield those with desired properties. The added costs during manufacturing currently make nanotubes only practical for high-value applications such as digital logic devices.

“Although these nanoparticles and their end products are very different, the stakeholders in their manufacture can learn much from each other’s best practices,” said NIST materials scientist and co-author J. Alexander Liddle. “By sharing knowledge, they might be able to improve both seemingly disparate operations.”

Finding ways like this to connect the dots, the authors said, is critically important for new ventures seeking to transfer nanoparticle technologies from laboratory to market.

“Nanoparticle manufacturing can become so costly that funding expires before the end product can be commercialized,” said WTEC nanotechnology consultant and co-author Michael Stopa. “In our paper, we outlined several opportunities for improving the odds that new ventures will survive their journeys through this technology transfer ‘valley of death.’”

Finally, the authors considered how manufacturing challenges and innovations are affecting the ever-growing number of applications for nanoparticles, including those in the areas of electronics, energy, health care and materials.

Here’s a link to and a citation for the paper,

Nanoparticle Manufacturing – Heterogeneity through Processes to Products by Samuel M. Stavis, Jeffrey A. Fagan, Michael Stopa, and J. Alexander Liddle. ACS Appl. Nano Mater., Article ASAP DOI: 10.1021/acsanm.8b01239 Publication Date (Web): August 16, 2018

Copyright © 2018 American Chemical Society

This paper is behind a paywall.

I looked at this paper briefly and found it to give a good overview. The focus is on manufacturing and making money. I imagine any discussion about the life cycle of the materials and possible environmental and health risks would have been considered ‘scope creep’.

I have two postings that provide additional information about manufacturing concerns, my February 10, 2014 posting:  ‘Valley of Death’, ‘Manufacturing Middle’, and other concerns in new government report about the future of nanomanufacturing in the US and my September 5, 2016 posting: An examination of nanomanufacturing and nanofabrication.

Chinese scientists strike gold in plant tissues

I have heard of phytomining in soil remediation efforts (reclaiming nanoscale metals in plants near mining operations; you can find a more detailed definition here at Wiktionary) but, in this case, scientists have discovered plant tissues with nanoscale gold in an area which has no known deposits of gold. From a June 14, 2018 news item on Nanowwerk (Note: A link has been removed),

Plants containing the element gold are already widely known. The flowering perennial plant alfafa, for example, has been cultivated by scientists to contain pure gold in its plant tissue. Now researchers from the Sun Yat-sen University in China have identified and investigated the characteristics of gold nanoparticles in two plant species growing in their natural environments.

The study, led by Xiaoen Luo, is published in Environmental Chemistry Letters (“Discovery of nano-sized gold particles in natural plant tissues”) and has implications for the way gold nanoparticles are produced and absorbed from the environment.

A June 14, 2018 Springer Publications press release, which originated the news item, delves further and proposes a solution to the mystery,

Xiaoen Luo and her colleagues investigated the perennial shrub B. nivea and the annual or biennial weed Erigeron Canadensis. The researchers collected and prepared samples of both plants so that they could be examined using the specialist analytical tool called field-emission transmission electron microscope (TEM).

Gold-bearing nanoparticles – tiny gold particles fused with another element such as oxygen or copper – were found in both types of plant. In E. Canadensis these particles were around 20-50 nm in diameter and had an irregular form. The gold-bearing particles in B. nivea were circular, elliptical or bone-rod shaped with smooth edges and were 5-15 nm.

“The abundance of gold in the crust is very low and there was no metal deposit in the sampling area so we speculate that the source of these gold nanoparticles is a nearby electroplating plant that uses gold in its operations, “ explains Jianjin Cao who is a co-author of the study.

Most of the characteristics of the nanoparticles matched those of artificial particles rather than naturally occurring nanoparticles, which would support this theory. The researchers believe that the gold-bearing particles were absorbed through the pores of the plants directly, indicating that gold could be accumulated from the soil, water or air.

“Discovering gold-bearing nanoparticles in natural plant tissues is of great significance and allows new possibilities to clean up areas contaminated with nanoparticles, and also to enrich gold nanoparticles using plants,” says Xiaoen Luo.

The researchers plan to further study the migration mechanism, storage locations and growth patterns of gold nanoparticles in plants and also verify the absorbing capacity of different plants for gold nanoparticles in polluted areas.

For anyone who’d like to find out more about electroplating, there’s this January 25, 2018 article by Anne Marie Helmenstine for ThoughtCo.

Here’s a link to and a citation for the paper,

Discovery of nano-sized gold particles in natural plant tissues by Xiaoen Luo (Luo, X.) and Jianjin Cao (Cao, J.). Environ Chem Lett (2018) pp 1–8 First published online 14 June 2018

This paper appears to be open access.

Creating cheap, small carbon nanotubes

The excitement fairly crackles off the video,

A May 24, 2018 news item on Nanowerk announces the research,

Imagine a box you plug into the wall that cleans your toxic air and pays you cash.

That’s essentially what Vanderbilt University researchers produced after discovering the blueprint for turning the carbon dioxide into carbon nanotubes with small diameters.

Carbon nanotubes are supermaterials that can be stronger than steel and more conductive than copper. The reason they’re not in every application from batteries to tires is that these amazing properties only show up in the tiniest nanotubes, which are extremely expensive. Not only did the Vanderbilt team show they can make these materials from carbon dioxide sucked from the air, but how to do this in a way that is much cheaper than any other method out there.

I’m not sure what ‘small’ means in this context. I’ve heard of long and short carbon nanotubes (CNTs) and also of single-walled, multi-walled, and double-walled CNTs. I wish there’d been an an explanation and measurements for ‘small diameter CNTs’. That nitpick aside, a May 23, 2018 Vanderbilt University news release by Heidi Hall adds a few more technical details,

These materials, which Assistant Professor of Mechanical Engineering Cary Pint calls “black gold,” could steer the conversation from the negative impact of emissions to how we can use them in future technology.

“One of the most exciting things about what we’ve done is use electrochemistry to pull apart carbon dioxide into elemental constituents of carbon and oxygen and stitch together, with nanometer precision, those carbon atoms into new forms of matter,” Pint said. “That opens the door to being able to generate really valuable products with carbon nanotubes.

“These could revolutionize the world.”

In a report published today in ACS [American Chemical Society] Applied Materials and Interfaces, Pint, interdisciplinary material science Ph.D. student Anna Douglas and their team describe how tiny nanoparticles 10,000 times smaller than a human hair can be produced from coatings on stainless steel surfaces. The key was making them small enough to be valuable.

“The cheapest carbon nanotubes on the market cost around $100-200 per kilogram,” Douglas said. “Our research advance demonstrates a pathway to synthesize carbon nanotubes better in quality than these materials with lower cost and using carbon dioxide captured from the air.”

But making small nanotubes is no small task. The research team showed that a process called Ostwald ripening — where the nanoparticles that grow the carbon nanotubes change in size to larger diameters — is a key contender against producing the infinitely more useful size. The team showed they could partially overcome this by tuning electrochemical parameters to minimize these pesky large nanoparticles.

side-by-side photos showing stainless steel plate becoming covered in carbon nanotubes (which look like lumps of ash or mud)
Small diameter carbon nanotubes grown on a stainless steel surface. (Pint Lab/Vanderbilt University)

This core technology led Pint and Douglas to co-found SkyNano LLC, a company focused on building upon the science of this process to scale up and commercialize products from these materials.

“What we’ve learned is the science that opens the door to now build some of the most valuable materials in our world, such as diamonds and single-walled carbon nanotubes, from carbon dioxide that we capture from air through our process,” Pint said.

Here’s a link to and a citation for the paper,

Toward Small-Diameter Carbon Nanotubes Synthesized from Captured Carbon Dioxide: Critical Role of Catalyst Coarsening by Anna Douglas, Rachel Carter, Mengya Li, and Cary L. Pint. ACS Appl. Mater. Interfaces, Article ASAP DOI: 10.1021/acsami.8b02834 Publication Date (Web): May 1, 2018

Copyright © 2018 American Chemical Society

This paper is behind a paywall.

Regarding the start-up, SkyNano, which Douglas and Pint have co-founded, it looks to be at a  very early stage.

7nm (nanometre) chip shakeup

From time to time I check out the latest on attempts to shrink computer chips. In my July 11, 2014 posting I noted IBM’s announcement about developing a 7nm computer chip and later in my July 15, 2015 posting I noted IBM’s announcement of a working 7nm chip (from a July 9, 2015 IBM news release , “The breakthrough, accomplished in partnership with GLOBALFOUNDRIES and Samsung at SUNY Polytechnic Institute’s Colleges of Nanoscale Science and Engineering (SUNY Poly CNSE), could result in the ability to place more than 20 billion tiny switches — transistors — on the fingernail-sized chips that power everything from smartphones to spacecraft.”

I’m not sure what happened to the IBM/Global Foundries/Samsung partnership but Global Foundries recently announced that it will no longer be working on 7nm chips. From an August 27, 2018 Global Foundries news release,

GLOBALFOUNDRIES [GF] today announced an important step in its transformation, continuing the trajectory launched with the appointment of Tom Caulfield as CEO earlier this year. In line with the strategic direction Caulfield has articulated, GF is reshaping its technology portfolio to intensify its focus on delivering truly differentiated offerings for clients in high-growth markets.

GF is realigning its leading-edge FinFET roadmap to serve the next wave of clients that will adopt the technology in the coming years. The company will shift development resources to make its 14/12nm FinFET platform more relevant to these clients, delivering a range of innovative IP and features including RF, embedded memory, low power and more. To support this transition, GF is putting its 7nm FinFET program on hold indefinitely [emphasis mine] and restructuring its research and development teams to support its enhanced portfolio initiatives. This will require a workforce reduction, however a significant number of top technologists will be redeployed on 14/12nm FinFET derivatives and other differentiated offerings.

I tried to find a definition for FinFet but the reference to a MOSFET and in-gate transistors was too much incomprehensible information packed into a tight space, see the FinFET Wikipedia entry for more, if you dare.

Getting back to the 7nm chip issue, Samuel K. Moore (I don’t think he’s related to the Moore of Moore’s law) wrote an Aug. 28, 2018 posting on the Nanoclast blog (on the IEEE [Institute of Electronics and Electrical Engineers] website) which provides some insight (Note: Links have been removed),

In a major shift in strategy, GlobalFoundries is halting its development of next-generation chipmaking processes. It had planned to move to the so-called 7-nm node, then begin to use extreme-ultraviolet lithography (EUV) to make that process cheaper. From there, it planned to develop even more advanced lithography that would allow for 5- and 3-nanometer nodes. Despite having installed at least one EUV machine at its Fab 8 facility in Malta, N.Y., all those plans are now on indefinite hold, the company announced Monday.

The move leaves only three companies reaching for the highest rungs of the Moore’s Law ladder: Intel, Samsung, and TSMC.

It’s a huge turnabout for GlobalFoundries. …

GlobalFoundries rationale for the move is that there are not enough customers that need bleeding-edge 7-nm processes to make it profitable. “While the leading edge gets most of the headlines, fewer customers can afford the transition to 7 nm and finer geometries,” said Samuel Wang, research vice president at Gartner, in a GlobalFoundries press release.

“The vast majority of today’s fabless [emphasis mine] customers are looking to get more value out of each technology generation to leverage the substantial investments required to design into each technology node,” explained GlobalFoundries CEO Tom Caulfield in a press release. “Essentially, these nodes are transitioning to design platforms serving multiple waves of applications, giving each node greater longevity. This industry dynamic has resulted in fewer fabless clients designing into the outer limits of Moore’s Law. We are shifting our resources and focus by doubling down on our investments in differentiated technologies across our entire portfolio that are most relevant to our clients in growing market segments.”

(The dynamic Caulfield describes is something the U.S. Defense Advanced Research Agency is working to disrupt with its $1.5-billion Electronics Resurgence Initiative. Darpa’s [DARPA] partners are trying to collapse the cost of design and allow older process nodes to keep improving by using 3D technology.)

Fabless manufacturing is where the fabrication is outsourced and the manufacturing company of record is focused on other matters according to the Fabless manufacturing Wikipedia entry.

Roland Moore-Colyer (I don’t think he’s related to Moore of Moore’s law either) has written August 28, 2018 article for which also explores this latest news from Global Foundries (Note: Links have been removed),

EVER PREPPED A SPREAD for a party to then have less than half the people you were expecting show up? That’s probably how GlobalFoundries [sic] feels at the moment.

The chip manufacturer, which was once part of AMD, had a fabrication process geared up for 7-nanometre chips which its customers – including AMD and Qualcomm – were expected to adopt.

But AMD has confirmed that it’s decided to move its 7nm GPU production to TSMC, and Intel is still stuck trying to make chips based on 10nm fabrication.

Arguably, this could mark a stymieing of innovation and cutting-edge designs for chips in the near future. But with processors like AMD’s Threadripper 2990WX overclocked to run at 6GHz across all its 32 cores, in the real-world PC fans have no need to worry about consumer chips running out of puff anytime soon. µ

That’s all folks.

Maybe that’s not all

Steve Blank in a Sept. 10, 2018 posting on the Nanoclast blog (on the IEEE [Institute of Electrical and Electronics Engineers] website) provides some provocative commentary on the Global Foundries announcement (Note: A link has been removed),

For most of our lives, the idea that computers and technology would get better, faster, and cheaper every year was as assured as the sun rising every morning. The story “GlobalFoundries Halts 7-nm Chip Development”  doesn’t sound like the end of that era, but for you and anyone who uses an electronic device, it most certainly is.

Technology innovation is going to take a different direction.

This story just goes on and on

There was a new development according to a Sept. 12, 2018 posting on the Nanoclast blog by, again, Samuel K. Moore (Note Links have been removed),

At an event today [sept. 12, 2018], Apple executives said that the new iPhone Xs and Xs Max will contain the first smartphone processor to be made using 7 nm manufacturing technology, the most advanced process node. Huawei made the same claim, to less fanfare, late last month and it’s unclear who really deserves the accolades. If anybody does, it’s TSMC, which manufactures both chips.

TSMC went into volume production with 7-nm tech in April, and rival Samsung is moving toward commercial 7-nm production later this year or in early 2019. GlobalFoundries recently abandoned its attempts to develop a 7 nm process, reasoning that the multibillion-dollar investment would never pay for itself. And Intel announced delays in its move to its next manufacturing technology, which it calls a 10-nm node but which may be equivalent to others’ 7-nm technology.

There’s a certain ‘soap opera’ quality to this with all the twists and turns.