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Credibility slips according to US survey on public perceptions of scientists

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Figure 1. Perceptions of scientists’ credibility. [downloaded from https://www.annenbergpublicpolicycenter.org/annenberg-survey-finds-public-perceptions-of-scientists-credibility-slips/]

A June 26, 2024 news item on ScienceDaily describes the research, which resulted in the graphic you see in the above,

New analyses from the Annenberg Public Policy Center find that public perceptions of scientists’ credibility — measured as their competence, trustworthiness, and the extent to which they are perceived to share an individual’s values — remain high, but their perceived competence and trustworthiness eroded somewhat between 2023 and 2024. The research also found that public perceptions of scientists working in artificial intelligence (AI) differ from those of scientists as a whole.

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A June 26, 2024 Annenberg Public Policy Center of the University of Pennsylvania news release (also on EurekAlert and also received by email), which originated the news item, describes a series of surveys, how the information was gathered, and offers more detail about he results, Note 1: All links removed; Note 2: You can find links and citations for papers mentioned in the news release at the end of this posting.

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From 2018-2022, the Annenberg Public Policy Center (APPC) of the University of Pennsylvania relied on national cross-sectional surveys to monitor perceptions of science and scientists. In 2023-24, APPC moved to a nationally representative empaneled sample to make it possible to observe changes in individual perceptions.

The February 2024 findings, released today to coincide with the address by National Academy of  Sciences President Marcia McNutt on “The State of the Science,” come from an analysis of responses from an empaneled national probability sample of U.S. adults surveyed in February 2023 (n=1,638 respondents), November 2023 (n=1,538), and February 2024 (n=1,555).

Drawing on the 2022 cross-sectional data, in an article titled “Factors Assessing Science’s Self-Presentation model and their effect on conservatives’ and liberals’ support for funding science,” published in Proceedings of the National Academy of Sciences (September 2023), Annenberg-affiliated researchers Yotam Ophir (State University of New York at Buffalo and an APPC distinguished research fellow), Dror Walter (Georgia State University and an APPC distinguished research fellow), and Patrick E. Jamieson and Kathleen Hall Jamieson of the Annenberg Public Policy Center isolated factors that underlie perceptions of scientists (Factors Assessing Science’s Self-Presentation, or FASS). These factors predict public support for increased funding of science and support for federal funding of basic research.

The five factors in FASS are whether science and scientists are perceived to be credible and prudent, and whether they are perceived to overcome bias, correct error (self-correcting), and whether their work benefits people like the respondent and the country as a whole (beneficial). In a 2024 publication titled “The Politicization of Climate Science: Media Consumption, Perceptions of Science and Scientists, and Support for Policy” (May 26, 2024) in the Journal of Health Communication, the same team showed that these five factors mediate the relationship between exposure to media sources such as Fox News and outcomes such as belief in anthropogenic climate change, perception of the threat it poses, and support for climate-friendly policies such as a carbon tax.

Speaking about the FASS model, Jamieson, director of the Annenberg Public Policy Center and director of the survey, said that “because our 13 core questions reliably reduce to five factors with significant predictive power, the ASK survey’s core questions make it possible to isolate both stability and changes in public perception of science and scientists across time.” (See the appendix for the list of questions.)

The new research finds that while scientists are held in high regard, two of the three dimensions that make up credibility – perceptions of competence and trustworthiness – showed a small but statistically significant drop from 2023 to 2024, as did both measures of beneficial. The 2024 survey data also indicate that the public considers AI scientists less credible than scientists in general, with notably fewer people saying that AI scientists are competent and trustworthy and “share my values” than scientists generally.

“Although confidence in science remains high overall, the survey reveals concerns about AI science,” Jamieson said. “The finding is unsurprising. Generative AI is an emerging area of science filled with both great promise and great potential peril.”

The data are based on Annenberg Science Knowledge (ASK) waves of the Annenberg Science and Public Health (ASAPH) surveys conducted in 2023 and 2024. The findings labeled 2023 are based on a February 2023 survey, and the findings labeled 2024 are based on combined ASAPH survey half-samples surveyed in November 2023 and February 2024.

For further details, download the toplines and a series of figures that accompany this summary.

Perceptions of scientists overall

In the FASS model, perceptions of scientists’ credibility are assessed through perceptions of whether scientists are competent, trustworthy, and “share my values.” The first two of those values slipped in the most recent survey. In 2024, 70% of those surveyed strongly or somewhat agree that scientists are competent (down from 77% in 2023) and 59% strongly or somewhat agree that scientists are trustworthy (down from 67% in 2023). (See figure 1 [see the first item in this post], and figs. 2-4 for other findings.)

The survey also found that in 2024, fewer people felt that scientists’ findings benefit “the country as a whole” and “benefit people like me.” In 2024, 66% strongly or somewhat agreed that findings benefit the country as a whole (down from 75% in 2023). Belief that scientists’ findings “benefit people like me,” also declined, to 60% from 68%. Taken together those two questions make up the beneficial factor of FASS. (See fig. 5.)

The findings follow sustained attacks on climate and Covid-19-related science and, more recently, public concerns about the rapid development and deployment of artificial intelligence.

Comparing perceptions of scientists in general with climate and AI scientists

Credibility: When asked about three factors underlying scientists’ credibility, AI scientists have lower credibility in all three values. (See fig. 6.)

  • Competent: 70% strongly/somewhat agree that scientists are competent, but only 62% for climate scientists and 49% for AI scientists.
  • Trustworthy: 59% agree scientists are trustworthy, 54% agree for climate scientists, 28% for AI scientists.
  • Share my values: A higher number (38%) agree that climate scientists share my values than for scientists in general (36%) and AI scientists (15%). More people disagree with this for AI scientists (35%) than for the others.

Prudence: Asked whether they agree or disagree that science by various groups of scientists “creates unintended consequences and replaces older problems with new ones,” over half of those surveyed (59%) agree that AI scientists create unintended consequences and just 9% disagree. (See fig. 7.)

Overcoming bias: Just 42% of those surveyed agree that scientists “are able to overcome human and political biases,” but only 21% feel that way about AI scientists. In fact, 41% disagree that AI scientists are able to overcome human political biases. In another area, just 23% agree that AI scientists provide unbiased conclusions in their area of inquiry and 38% disagree. (See fig. 8.)

Self-correction: Self-correction, or “organized skepticism expressed in expectations sustaining a culture of critique,” as the FASS paper puts it, is considered by some as a “hallmark of science.” AI scientists are seen as less likely than scientists or climate scientists to take action to prevent fraud; take responsibility for mistakes; or to have mistakes that are caught by peer review. (See fig. 9.)

Benefits: Asked about the benefits from scientists’ findings, 60% agree that scientists’ “findings benefit people like me,” though just 44% agree for climate scientists and 35% for AI scientists. Asked about whether findings benefit the country as a whole, 66% agree for scientists, 50% for climate scientists and 41% for AI scientists. (See fig. 10.)

Your best interest: The survey also asked respondents how much trust they have in scientists to act in the best interest of people like you. (This specific trust measure is not a part of the FASS battery.) Respondents have less trust in AI scientists than in others: 41% have a great deal/a lot of trust in medical scientists; 39% in climate scientists; 36% in scientists; and 12% in AI scientists. (See fig. 11.)

The data from ASK surveys have been used to date in four peer-reviewed papers:

  • Using 2019 ASK data: Jamieson, K. H., McNutt, M., Kiermer, V., & Sever, R. (2019). Signaling the trustworthiness of science. Proceedings of the National Academy of Sciences, 116(39), 19231-19236.
  • Using 2022 ASK data: Ophir, Y., Walter, D., Jamieson, P. E., & Jamieson, K. H. (2023). Factors Assessing Science’s Self-Presentation model and their effect on conservatives’ and liberals’ support for funding science. Proceedings of the National Academy of Sciences, 120(38), e2213838120.
  • Using  2024 ASK data: Lupia, A., Allison, D. B., Jamieson, K. H., Heimberg, J., Skipper, M., & Wolf, S. M. (2024). Trends in US public confidence in science and opportunities for progress. Proceedings of the National Academy of Sciences, 121(11), e2319488121. 
  • Using Nov 2023 and Feb 2024 ASK data: Ophir, Y., Walter, D., Jamieson, P. E., & Jamieson, K. H. (2024). The politicization of climate science: Media consumption, perceptions of science and scientists, and support for policy. Journal of Health Communication, 29(sup1): 18-27.
     

APPC’s ASAPH survey

The survey data come from the 17th and 18th waves of a nationally representative panel of U.S. adults, first empaneled in April 2021, conducted for the Annenberg Public Policy Center by SSRS, an independent market research company. These waves of the Annenberg Science and Public Health (ASAPH) knowledge survey were fielded February 22-28, 2023, November 14-20, 2023, and February 6-12, 2024, and have margins of sampling error (MOE) of ± 3.2, 3.3 and 3.4 percentage points at the 95% confidence level. In November 2023, half of the sample was asked about “scientists” and the other half “climate scientists.” In February 2024, those initially asked about “scientists” were asked about “scientists studying AI” and the other half “scientists.” This provided two half samples addressing specific areas of study, while all panelists were asked about “scientists” generally. All figures are rounded to the nearest whole number and may not add to 100%. Combined subcategories may not add to totals in the topline and text due to rounding.

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The policy center has been tracking the American public’s knowledge, beliefs, and behaviors regarding vaccination, Covid-19, flu, maternal health, climate change, and other consequential health issues through this survey panel for over three years. In addition to Jamieson, the APPC team includes Shawn Patterson Jr., who analyzed the data; Patrick E. Jamieson, director of the Annenberg Health and Risk Communication Institute, who developed the questions; and Ken Winneg, managing director of survey research, who supervised the fielding of the survey.

Here are links to and citations for the papers listed above in the June 26, 2024 news release,

Using 2019 ASK data: Signaling the trustworthiness of science by Kathleen Hall Jamieson, Marcia McNutt, Veronique Kiermer, and Richard Sever.. Proceedings of the National Academy of Sciences (PNAS), 116 (39), 19231-19236 September 23, 2019 DOI: https://doi.org/10.1073/pnas.1913039116

Using 2022 ASK data Factors Assessing Science’s Self-Presentation model and their effect on conservatives’ and liberals’ support for funding science by Yotam Ophir, Dror Walter, Patrick E. Jamieson, and Kathleen Hall Jamieson.. Proceedings of the National Academy of Sciences (PNAS), 120 (38), e2213838120 September 11, 2023 DOI: https://doi.org/10.1073/pnas.2213838120

Using  2024 ASK data: Trends in US public confidence in science and opportunities for progress by Arthur Lupia, David B. Allison, Kathleen Hall Jamieson, Jennifer Heimberg, Magdalena Skipper, and Susan M. Wolf.. Proceedings of the National Academy of Sciences (PNAS), 121 (11), e2319488121 March 4, 2024 DOI: https://doi.org/10.1073/pnas.2319488121 

Using Nov 2023 and Feb 2024 ASK data: The politicization of climate science: Media consumption, perceptions of science and scientists, and support for policy by by Yotam Ophir, Dror Walter, Patrick E. Jamieson & Kathleen Hall Jamieson.. Journal of Health Communication, 29 (sup1): 18-27 DOI: https://doi.org/10.1080/10810730.2024.2357571 Published online: 26 May 2024

The 2019 paper ‘Signaling …’ has been featured here before in a September 30, 2019 posting, “Do you believe in science?” In addition to some of my comments, I embedded Adam Lambert’s version of Cher’s song ‘Do You Believe in Love?’ where you’ll see Cher brush away a few tears as she listens to her dance hit made love ballad.

The 2024 paper ‘Trends ..’ has also been featured here, albeit briefly, in an April 8, 2024 posting, “Trust in science remains high but public questions scientists’ adherence to science’s norms.”

2024 Kavli Prize Laureates: in the fields of astrophysics, nanoscience and neuroscience

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The Kavli Prize has yet to acquire the lustre of a Nobel Prize (first awarded in 1901 as per its Wikipedia entry). By comparison the Kavli Prize is relatively new (established in 2005 as per its Wikipedia entry) but it appears to be achieving big deal status in the US.

This year’s crop of prize winners was listed in a June 12, 2024 Kavli Foundation news release on EurekAlert,

Eight scientists from three countries are honored for their research that has broadened our understanding of the big, the small and the complex.

June 12, 2024 (Oslo, Norway) — The Norwegian Academy of Science and Letters today announced the 2024 Kavli Prize Laureates in the fields of astrophysics, nanoscience and neuroscience. Eight scientists from three countries are honored for their research that has broadened our understanding of the big, the small and the complex. The laureates in each field will share $1 million USD. 

The 2024 Kavli Prizes recognize groundbreaking science for the discovery and characterization of extra-solar planets and their atmospheres; foundational research integrating synthetic nanoscale materials for biomedical use; and the localization of areas in the brain specialized for face recognition and processing.  

The 2024 Kavli Prize Laureates are:  

  • Kavli Prize in Astrophysics: David Charbonneau (Canada/USA) and Sara Seager (Canada/USA) 
  • Kavli Prize in Nanoscience: Robert S. Langer (USA), Armand Paul Alivisatos (USA) and Chad A. Mirkin (USA) 
  • Kavli Prize in Neuroscience: Nancy Kanwisher (USA), Winrich Freiwald (Germany), and Doris Tsao (USA) 

“The Kavli Prize 2024 honors outstanding researchers doing fundamental science that moves the world forward. They are exploring planets outside our solar system; they have broadened the scientific field of nanoscience towards biomedicine; and they are adding to our understanding of the neurological basis of face recognition,” said Lise Øvreås, president at The Norwegian Academy of Science and Letters.  

Astrophysics: Searching for life beyond Earth  

The 2024 Kavli Prize in Astrophysics honors Sara Seager and David Charbonneau for discoveries of exoplanets and the characterization of their atmospheres. They pioneered methods for the detection of atomic species in planetary atmospheres and the measurement of their thermal infrared emission, setting the stage for finding the molecular fingerprints of atmospheres around both giant and rocky planets. Their contributions have been key to the enormous progress seen in the last 20 years in the exploration of myriad exo-planets.  

“Humans have always looked towards the stars for discoveries. The pivotal research conducted by Seager and Charbonneau has been an important first step towards finding new planets and strong evidence of life elsewhere in the universe,” remarked Viggo Hansteen, Chair of the Astrophysics Committee.  

David Charbonneau led the team that used the transit method to discover a giant exoplanet (HD 209458b). He pioneered the application of space-based observatories to perform the first studies of the atmosphere of giant extrasolar planets. This new method measures the tiny amount of light blocked by such a planet as it passes in front of its host star. Charbonneau has also used the transit method to study exoplanetary atmospheres, measuring molecular spectra using both filtered starlight and infrared emission from the planets themselves. He demonstrated these two approaches with observations from the Hubble Space Telescope in 2002 and the Spitzer Space Telescope three years later.  

Sara Seager pioneered the theoretical study of planetary atmospheres and predicted the presence of atomic and molecular species detectable by transit spectroscopy, most notably the alkali gases. She predicted how transits could be used to measure atomic and molecular characteristics in exoplanetary atmospheres, which is crucial for identifying biomarkers – signs of life. Seager made outstanding contributions to the understanding of planets with masses below that of Neptune. She also carried out extensive research on starshades – enormous petal-like structures designed to shield space observatories from the glare of a faraway Sun-like star – and was among the first to recognize their importance in detecting and characterizing the faint light from any Earth-like planet orbiting the star. 

Nanoscience: Integrating nanomaterials for biomedical advances 

The 2024 Kavli Prize in Nanoscience honors Robert S. Langer, Armand Paul Alivisatos and Chad A. Mirkin who each revolutionized the field of nanomedicine by demonstrating how engineering nanoscale materials can advance biomedical research and application. Their discoveries contributed foundationally to the development of therapeutics, vaccines, bioimaging and diagnostics.   

“The three scientists, Langer, Alivisatos and Mirkin, have broadened the scientific field of nanoscience, building from fundamental research. By scientific curiosity they have become inventors for the future of nanoscience and biomedicine,” stated Bodil Holst, Chair of the Nanoscience Committee.  

Robert S. Langer was the first to develop nano-engineered materials that enabled the controlled release, or regular flow, of drug molecules. This capability has had an immense impact for the treatment of a range of diseases, such as aggressive brain cancer, prostate cancer and schizophrenia. His work also showed that tiny particles, containing protein antigens, can be used in vaccination, and was instrumental in the development of the delivery of mRNA vaccines. 

Armand Paul Alivisatos demonstrated that semiconductor nanocrystals, or quantum dots (nanoparticles that possess bright, size-dependent light-emitting properties), can be used as multicolor probes in bioimaging. Essential to this achievement was the synthesis of biocompatible nanocrystals. Semiconductor nanocrystals became the basis for the widely used research and diagnostic tools such as live cell tracking, labelling and in vivo imaging. 

Chad A. Mirkin engineered spherical nucleic acids (SNA) using a gold nanoparticle as the core, and a cloud of radially distributed DNA or RNA strands as the shell. He was then able to show how SNAs can be combined to create larger structures and how they can be used in biodiagnostics. His discovery led to the development of fast, automated point-of-care medical diagnostic systems.  

Neuroscience: Understanding recognition of faces 

The 2024 Kavli Prize in Neuroscience honors Nancy Kanwisher, Doris Tsao and Winrich Freiwald for the discovery of a specialized system within the brain to recognize faces. Their discoveries have provided basic principles of neural organization and made the starting point for further research on how the processing of visual information is integrated with other cognitive functions.  

“Kanwisher, Freiwald and Tsao together discovered a localized and specialized neocortical system for face recognition. Their outstanding research will ultimately further our understanding of recognition not only of faces, but objects and scenes,” commented Kristine Walhovd, Chair of the Neuroscience Committee.  

Nancy Kanwisher was the first to prove that a specific area in the human neocortex is dedicated to recognizing faces, now called the fusiform face area. Using functional magnetic resonance imaging (fMRI) she found individual differences in the location of this area and devised an analysis technique to effectively localize specialized functional regions in the brain. This technique is now widely used and applied to domains beyond the face recognition system.  

Elaborating on Kanwisher’s findings, Winrich Freiwald and Doris Tsao studied macaques and mapped out six distinct brain regions, known as the face patch system, including these regions’ functional specialization and how they are connected. By recording the activity of individual brain cells, they revealed how cells in some face patches specialize in faces with particular views.  

Tsao proceeded to identify how the face patches work together to identify a face, through a specific code that enables single cells to identify faces by assembling information of facial features. For example, some cells respond to the presence of hair, others to the distance between the eyes. 

Freiwald uncovered that a separate brain region, called the temporal pole, accelerates our recognition of familiar faces, and that some cells are selectively responsive to familiar faces. 

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There’s a video of the official 2024 Kavli Prize announcement which despite the Kavli Foundation being headquartered in California, US, was held (as noted in the news release) at the Norwegian Academy of Science and Letters where the organization’s president, Lise Øvreås, revealed the 2024 Kavli Prize laureates..(I’ll get back to that choice of location.)

The 2024 Kavli Prize in Nanoscience

There are many posts here featuring work from Robert S. Langer (or Robert Langer), Armand Paul Alivisatos (or Paul Alivisatos or A. Paul Alivisatos) and Chad A. Mirkin (or Chad Mirkin).

Northwestern University (Chicago, Illinois) issued a June 12, 2024 news release (also received via email) by Maria Paul that provides a few more details about the nanoscience winners (main focus: Chad Mirkin), the prize, and the Kavli Foundation. Note: A link has been removed,

Northwestern University nanoscientist Chad Mirkin has been awarded The 2024 Kavli Prize in Nanoscience by The Norwegian Academy of Science and Letters. Mirkin is the first Northwestern scientist to receive the prestigious award.

Mirkin is recognized for his discovery of spherical nucleic acids (SNAs), nanostructures comprised of a nanoparticle core and a shell of radially distributed DNA or RNA strands. These globular forms of nucleic acids have become the cornerstones of the burgeoning fields of nanomedicine and colloidal crystal engineering with DNA. They allow scientists to construct new forms of matter using particle “atoms” as the basic building blocks and DNA “bonds” as particle interconnects, and they are the basis for powerful tools that allow researchers and clinicians to track and treat disease in new ways. In particular, SNAs have led to the development of fast, automated point-of-care medical diagnostic systems and new experimental drugs for treating many forms of cancer, neurological disorders, and diseases of the skin.

Mirkin is one of three laureates in nanoscience recognized by The Norwegian Academy for revolutionizing the field of nanomedicine by demonstrating how engineering nanoscale structures can advance biomedical research and application. The other two are Robert Langer of the Massachusetts Institute of Technology and Paul Alivisatos of the University of Chicago [emphasis mine]. The scientists’ discoveries “contributed foundationally to the development of therapeutics, vaccines, bioimaging and diagnostics,” The Norwegian Academy said in a release. They will share the $1 million award.

“When I first found out I won The Kavli Prize, there was both excitement but also relief, because I consider Northwestern to be the ultimate center for nanotechnology research,” Mirkin said. “To be recognized with this award, along with my incredible co-awardees, was great validation of what we’ve been trying to do at Northwestern. While I’m proud of what we’ve accomplished, the best is yet to come.”

The laureates will be awarded the prize on Sept. 3 during a ceremony in Oslo, Norway, presided over the by The Royal Family. The Kavli Prizes thus far have honored 65 scientists from 13 countries. Ten laureates received the Nobel Prize after receiving The Kavli Prize. [emphasis mine]

“I am thrilled for Chad, for the International Institute for Nanotechnology and for Northwestern,” Northwestern President Michael Schill said. “Chad has earned this prestigious and influential award in a pathbreaking area of science that is aligned with two of the University’s key priorities — to lead in decarbonization, renewable energy and sustainability, and innovating in the biosciences to help prolong lives and make the world a healthier place.

“Through groundbreaking research and hard work, Chad and his team have made Northwestern a leading center for nanotechnology research and investment. The fact that he is sharing this award with President Alivisatos at U of C further emphasizes how the Chicago area has become an international hub for nano research.”

The vision for The Kavli Prize comes from Fred Kavli, a Norwegian-American entrepreneur and philanthropist [emphasis mine] who turned his lifelong fascination with science into a lasting legacy for recognizing scientific breakthroughs and supporting basic research.

Since the first awards in 2008, The Kavli Prize has recognized innovative scientific research — from the discovery of CRISPR-Cas9 to the detection of gravitational waves — transforming our understanding of the big, the small and the complex.

Mirkin’s discovery of SNAs has far-reaching implications for biology and medicine. SNAs, which have no known natural equivalents, interact uniquely with living systems compared to nucleic acids of other forms. Mirkin was the first to synthesize SNAs and elucidate the distinctive chemical and physical properties that underpin their use in transformative techniques and technologies in medicine and the life sciences. This work has led to the development of the first commercialized molecular medical diagnostic systems of the modern nanotechnology era, such as the Food and Drug Administration-cleared Verigene System, used in over half of the world’s top hospitals to detect diseases with high sensitivity and selectivity.

Illinois Gov. JB Pritzker praised Mirkin for his extraordinary contributions to the field of nanotechnology and how his innovations have helped find solutions to some of society’s biggest challenges.

“Academic institutions in Chicago and across Illinois have become the biggest drivers in nanoscience and technology over the last three decades,” Pritzker said. “Chad Mirkin and his Northwestern colleagues have made outstanding scientific discoveries that change how we view the world around us.”

In 1996, Mirkin created the first SNAs with DNA shells on gold nanoparticle cores. Over the years, he has developed numerous other types of SNAs with other shells and cores, including proteins, liposomes and FDA-approved materials, as well as core-less, hollow structures composed entirely of nucleic acids. These cores impart unique properties to the SNAs, such as optical and magnetic characteristics, while also serving as scaffolds to densely arrange the oligonucleotides, which participate in binding. This dense arrangement gives rise to the novel functional properties that differentiate SNAs from the natural linear and two-dimensional nucleic acids and make them particularly effective in interacting with certain biological structures within cells and tissues. SNAs, unlike conventional DNA and RNA, are naturally taken up by cells without the need for toxic, positively charged co-carriers, making them highly effective in RNA interference (RNAi), antisense gene regulation, and gene editing pathways.

Mirkin’s pioneering work on SNAs has also advanced the development of immunotherapeutics, structures capable of stimulating a patient’s immune response to fight both infectious diseases and certain forms of cancer. Using SNAs, Mirkin has pioneered the concept of rational vaccinology, where he demonstrated that the structure of a vaccine, rather than the components alone, is crucial for dictating its therapeutic effectiveness. This insight and these “structural nanomedicines” have opened new possibilities for developing curative treatments by rearranging known components into more effective structures at the nanoscale. Mirkin founded Flashpoint Therapeutics to commercialize these innovations, focusing on nucleic acid-based nanostructure cancer vaccines. Mirkin also invented the first SNA-based antiviral vaccine, using COVID-19 as a model. These SNAs, featuring the spike protein’s RBD subunit in the core, achieved a 100% survival rate in humanized mice challenged with the live virus. These structures and concepts for designing such vaccines are poised to move vaccine development beyond the current mRNA vaccines.

In addition, Mirkin invented dip-pen nanolithography, initially a technique for molecular writing with nanometer-scale precision that has evolved into a powerful platform for tip-based materials synthesis that, when combined with artificial intelligence, is revolutionizing how materials important for many sectors, especially clean energy, are discovered. Dip-pen nanolithography, which has spurred subsequent techniques that now use tens of millions of tiny tips to rapidly synthesize materials to be explored for such purposes, was recognized by National Geographic as one of the “top 100 scientific discoveries that changed the world.” These innovations are being commercialized by Mattiq, Inc., another venture-backed company Mirkin cofounded. Mirkin and his students also invented high-area rapid printing, an additive manufacturing technology, that is being commercialized by Azul 3D and being used to disrupt the microelectronics and optical lens industries.

Mirkin’s research has progressed SNA drugs through seven human clinical trials so far for treating various cancers, including glioblastoma multiforme and Merkel cell carcinoma. One SNA drug has shown remarkable potential in stimulating the immune system, proving effective in models of breast, colorectal and bladder cancers, lymphoma and melanoma. This drug has achieved complete tumor elimination in a subset of patients with Merkel cell carcinoma during Phase 1b/2 clinical trials, earning FDA fast-track and orphan drug status. It was recently licensed to Bluejay Therapeutics to treat hepatitis.

In 2000, Mirkin founded the International Institute for Nanotechnology (IIN) at Northwestern University, which he also directs. Research at the IIN has led to over 2,000 new commercial products sold globally and the creation of more than 40 startup companies. The IIN has collectively brought together over $1.2 billion to support research, education and infrastructure at Northwestern since its inception.

Mirkin is the George B. Rathmann Professor of Chemistry and a professor of medicine, chemical and biological engineering, biomedical engineering, and materials science and engineering at Northwestern. He is among an elite group of scientists elected to all three branches of the U.S. National Academies — the National Academy of Sciences, the National Academy of Engineering and the National Academy of Medicine. He is a member of the American Academy of Arts and Sciences. Mirkin served on President Obama’s Council of Advisors on Science and Technology for eight years.

Congratulations to all of the winners in all of the categories!

As for the Norway announcement, it makes a bit of sense given that Fred Kavli was a Norwegian American. However, it’s a little hard to avoid the suspicion that there might be some regional and prize rivalry between Norway with its Kavli and Sweden its Nobel..

Trust in science remains high but public questions scientists’ adherence to science’s norms

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A March 4, 2024 Annenberg Public Policy Center of the University of Pennsylvania news release (also on EurekAlert and received via email) announces research into public trust in science in the US,

Science is one of the most highly regarded institutions in America, with nearly three-quarters of the public expressing “a great deal” or “a fair amount” of confidence in scientists. But confidence in science has nonetheless declined over the past few years, since the early days of the Covid-19 pandemic, as it has for most other major social institutions.

In a new article, members of the Strategic Council of the National Academies of Sciences, Engineering, and Medicine [NASEM] examine what has happened to public confidence in science, why it has happened, and what can be done to elevate it. The researchers write that while there is broad public agreement about the values that should underpin science, the public questions whether scientists actually live up to these values and whether they can overcome their individual biases.

The paper, published in the Proceedings of the National Academy of Sciences (PNAS), relies in part on new data being released in connection with this article by the Annenberg Public Policy Center (APPC) of the University of Pennsylvania. The data come from the Annenberg Science Knowledge (ASK) survey conducted February 22-28, 2023, with an empaneled, nationally representative sample of 1,638 U.S. adults who were asked about their views on scientists and science. The margin of error for the entire sample is ± 3.2 percentage points at the 95% confidence level. (See the paper for the findings.) The survey is directed by APPC director Kathleen Hall Jamieson, a member of the Strategic Council and a co-author of the PNAS paper.

Decline in confidence comparable to other institutions

The researchers also examine trends in public confidence in science dating back 20 years from other sources, including the Pew Research Center and the General Social Survey of National Opinion Research at the University of Chicago. These show a recent decline consistent with the decline seen for other institutions.

“We’re of the view that trust has to be earned,” said lead author Arthur Lupia, a member of the NASEM’s Strategic Council for Research Excellence, Integrity, and Trust, and associate vice president for research at the University of Michigan. “We wanted to understand how trust in science is changing, and why, and is there anything that the scientific enterprise can do to regain trust?”

Highlights

“Confidence in science is high relative to nearly all other civic, cultural, and government institutions…,” the article states. In addition:

  • The public has high levels of confidence in scientists’ competence, trustworthiness, and honesty – 84% of survey respondents in February 2023 are very or somewhat confident that scientists provide the public with trustworthy information in the scientists’ area of inquiry.
  • Many in the public question whether scientists share their values and whether scientists can overcome their own biases. For instance, when asked whether scientists will or will not publish findings if a study’s results run counter to the interests of the organization running the study, 70% said scientists will not publish the findings.
  • The public has “consistent beliefs about how scientists should act and beliefs that support their confidence in science despite their concerns about scientists’ possible biases and distortive incentives.” For example, 84% of U.S. adults say it is somewhat or very important for scientists to disclose their funders and 92% say it is somewhat or very important that scientists be open to changing their minds based on new evidence.
  • However, when asked about scientists’ biases, just over half of U.S. adults (53%) say scientists provide the public with unbiased conclusions about their area of inquiry and just 42% say scientists generally are “able to overcome their human and political biases.”

Beyond measurements of trust in science

The Annenberg Public Policy Center’s ASK survey in February 2023 asked U.S. adults more nuanced questions about attitudes toward scientists.

“We’ve developed measures beyond trust or confidence in science in order to understand why some in the public are less supportive of science and scientists than others,” said Jamieson, who is also a professor of communication at the University of Pennsylvania’s Annenberg School for Communication. “Perceptions of whether scientists share one’s values, overcome their human and political biases, and correct mistakes are important as well.”

The ASK survey of U.S. adults found, for instance, that 81% regard scientists as competent, 70% as trustworthy, and 68% as honest, but only 42% say scientists “share my values.”

A more detailed analysis of the variables and effects seen in Annenberg’s surveys was published in September 2023 in PNAS in the paper “Factors Assessing Science’s Self-Presentation model and their effect on conservatives’ and liberals’ support for funding science.”

Confidence in science and Covid-19 vaccination status

The research published in PNAS was initiated by members of the NASEM’s Strategic Council for Research Excellence, Integrity, and Trust, which was established in 2021 to advance the integrity, ethics, resilience, and effectiveness of the research enterprise.

Lupia said the Strategic Council’s conversations about whether trust in science was declining and if so, why, began during the pandemic. “There was great science behind the Covid-19 vaccine, so why was the idea of people taking it so controversial?” he asked. “Covid deaths were so visible and yet the controversy over the vaccine was also so visible – kind of an icon of the public-health implications of declining trust in science.”

The article cites research from the Annenberg Public Policy Center that found important relationships between science-based forms of trust and the willingness to take a Covid-19 vaccine. Data from waves of another APPC survey of U.S. adults in five swing states during the 2020 campaign season – reported in a 2021 article in PNAS – showed that from July 2020 to February 2021, U.S. adults’ trust in health authorities was a significant predictor of the reported intention to get the Covid-19 vaccine. See the article “The role of non-COVID-specific and COVID-specific factors in predicting a shift in willingness to vaccinate: A panel study.”

How to raise confidence in science

Raising public confidence in science, the researchers write, “should not be premised on the assumption that society would be better off with higher levels of uncritical trust in the scientific community. Indeed, uncritical trust in science would violate the scientific norm of organized skepticism and be antithetical to science’s culture of challenge, critique, and self-correction.”

“Instead,” they propose, “researchers, scientific organizations, and the scientific community writ large need to redouble their commitment to conduct, communicate, critique, and – when error is found or misconduct detected – correct the published record in ways that both merit and earn public confidence.”

The data cited in the paper, they conclude, “suggest that the scientific community’s commitment to core values such as the culture of critique and correction, peer review, acknowledging limitations in data and methods, precise specification of key terms, and faithful accounts of evidence in every step of scientific practice and in every engagement with the public may help sustain confidence in scientific findings.”

“Trends in U.S. Public Confidence in Science and Opportunities for Progress” was published March 4, 2024, in PNAS. In addition to Jamieson and Lupia, the authors are David B. Allison, dean of the School of Public Health, Indiana University; Jennifer Heimberg, of the National Academies of Sciences, Engineering, and Medicine; Magdalena Skipper, editor-in-chief of the journal Nature; and Susan M. Wolf, of the University of Minnesota Law and Medical Schools. Allison is co-chair of the National Academies’ Strategic Council; Lupia, Jamieson, Skipper, and Wolf are members of the Council, and Heimberg is the director of the Council.

Here’s a link to and a citation for the paper,

Trends in U.S. public confidence in science and opportunities for progress by Arthur Lupia, David B. Allison, Kathleen Hall Jamieson, and Susan M. Wolf. PNAS March 4, 2024 121 (11) e2319488121 DOI: https://doi.org/10.1073/pnas.2319488121

This paper is open access.