Monthly Archives: July 2019

Human Brain Project: update

The European Union’s Human Brain Project was announced in January 2013. It, along with the Graphene Flagship, had won a multi-year competition for the extraordinary sum of one million euros each to be paid out over a 10-year period. (My January 28, 2013 posting gives the details available at the time.)

At a little more than half-way through the project period, Ed Yong, in his July 22, 2019 article for The Atlantic, offers an update (of sorts),

Ten years ago, a neuroscientist said that within a decade he could simulate a human brain. Spoiler: It didn’t happen.

On July 22, 2009, the neuroscientist Henry Markram walked onstage at the TEDGlobal conference in Oxford, England, and told the audience that he was going to simulate the human brain, in all its staggering complexity, in a computer. His goals were lofty: “It’s perhaps to understand perception, to understand reality, and perhaps to even also understand physical reality.” His timeline was ambitious: “We can do it within 10 years, and if we do succeed, we will send to TED, in 10 years, a hologram to talk to you.” …

It’s been exactly 10 years. He did not succeed.

One could argue that the nature of pioneers is to reach far and talk big, and that it’s churlish to single out any one failed prediction when science is so full of them. (Science writers joke that breakthrough medicines and technologies always seem five to 10 years away, on a rolling window.) But Markram’s claims are worth revisiting for two reasons. First, the stakes were huge: In 2013, the European Commission awarded his initiative—the Human Brain Project (HBP)—a staggering 1 billion euro grant (worth about $1.42 billion at the time). Second, the HBP’s efforts, and the intense backlash to them, exposed important divides in how neuroscientists think about the brain and how it should be studied.

Markram’s goal wasn’t to create a simplified version of the brain, but a gloriously complex facsimile, down to the constituent neurons, the electrical activity coursing along them, and even the genes turning on and off within them. From the outset, the criticism to this approach was very widespread, and to many other neuroscientists, its bottom-up strategy seemed implausible to the point of absurdity. The brain’s intricacies—how neurons connect and cooperate, how memories form, how decisions are made—are more unknown than known, and couldn’t possibly be deciphered in enough detail within a mere decade. It is hard enough to map and model the 302 neurons of the roundworm C. elegans, let alone the 86 billion neurons within our skulls. “People thought it was unrealistic and not even reasonable as a goal,” says the neuroscientist Grace Lindsay, who is writing a book about modeling the brain.
And what was the point? The HBP wasn’t trying to address any particular research question, or test a specific hypothesis about how the brain works. The simulation seemed like an end in itself—an overengineered answer to a nonexistent question, a tool in search of a use. …

Markram seems undeterred. In a recent paper, he and his colleague Xue Fan firmly situated brain simulations within not just neuroscience as a field, but the entire arc of Western philosophy and human civilization. And in an email statement, he told me, “Political resistance (non-scientific) to the project has indeed slowed us down considerably, but it has by no means stopped us nor will it.” He noted the 140 people still working on the Blue Brain Project, a recent set of positive reviews from five external reviewers, and its “exponentially increasing” ability to “build biologically accurate models of larger and larger brain regions.”

No time frame, this time, but there’s no shortage of other people ready to make extravagant claims about the future of neuroscience. In 2014, I attended TED’s main Vancouver conference and watched the opening talk, from the MIT Media Lab founder Nicholas Negroponte. In his closing words, he claimed that in 30 years, “we are going to ingest information. …

I’m happy to see the update. As I recall, there was murmuring almost immediately about the Human Brain Project (HBP). I never got details but it seemed that people were quite actively unhappy about the disbursements. Of course, this kind of uproar is not unusual when great sums of money are involved and the Graphene Flagship also had its rocky moments.

As for Yong’s contribution, I’m glad he’s debunking some of the hype and glory associated with the current drive to colonize the human brain and other efforts (e.g. genetics) which they often claim are the ‘future of medicine’.

To be fair. Yong is focused on the brain simulation aspect of the HBP (and Markram’s efforts in the Blue Brain Project) but there are other HBP efforts, as well, even if brain simulation seems to be the HBP’s main interest.

After reading the article, I looked up Henry Markram’s Wikipedia entry and found this,

In 2013, the European Union funded the Human Brain Project, led by Markram, to the tune of $1.3 billion. Markram claimed that the project would create a simulation of the entire human brain on a supercomputer within a decade, revolutionising the treatment of Alzheimer’s disease and other brain disorders. Less than two years into it, the project was recognised to be mismanaged and its claims overblown, and Markram was asked to step down.[7][8]

On 8 October 2015, the Blue Brain Project published the first digital reconstruction and simulation of the micro-circuitry of a neonatal rat somatosensory cortex.[9]

I also looked up the Human Brain Project and, talking about their other efforts, was reminded that they have a neuromorphic computing platform, SpiNNaker (mentioned here in a January 24, 2019 posting; scroll down about 50% of the way). For anyone unfamiliar with the term, neuromorphic computing/engineering is what scientists call the effort to replicate the human brain’s ability to synthesize and process information in computing processors.

In fact, there was some discussion in 2013 that the Human Brain Project and the Graphene Flagship would have some crossover projects, e.g., trying to make computers more closely resemble human brains in terms of energy use and processing power.

The Human Brain Project’s (HBP) Silicon Brains webpage notes this about their neuromorphic computing platform,

Neuromorphic computing implements aspects of biological neural networks as analogue or digital copies on electronic circuits. The goal of this approach is twofold: Offering a tool for neuroscience to understand the dynamic processes of learning and development in the brain and applying brain inspiration to generic cognitive computing. Key advantages of neuromorphic computing compared to traditional approaches are energy efficiency, execution speed, robustness against local failures and the ability to learn.

Neuromorphic Computing in the HBP

In the HBP the neuromorphic computing Subproject carries out two major activities: Constructing two large-scale, unique neuromorphic machines and prototyping the next generation neuromorphic chips.

The large-scale neuromorphic machines are based on two complementary principles. The many-core SpiNNaker machine located in Manchester [emphasis mine] (UK) connects 1 million ARM processors with a packet-based network optimized for the exchange of neural action potentials (spikes). The BrainScaleS physical model machine located in Heidelberg (Germany) implements analogue electronic models of 4 Million neurons and 1 Billion synapses on 20 silicon wafers. Both machines are integrated into the HBP collaboratory and offer full software support for their configuration, operation and data analysis.

The most prominent feature of the neuromorphic machines is their execution speed. The SpiNNaker system runs at real-time, BrainScaleS is implemented as an accelerated system and operates at 10,000 times real-time. Simulations at conventional supercomputers typical run factors of 1000 slower than biology and cannot access the vastly different timescales involved in learning and development ranging from milliseconds to years.

Recent research in neuroscience and computing has indicated that learning and development are a key aspect for neuroscience and real world applications of cognitive computing. HBP is the only project worldwide addressing this need with dedicated novel hardware architectures.

I’ve highlighted Manchester because that’s a very important city where graphene is concerned. The UK’s National Graphene Institute is housed at the University of Manchester where graphene was first isolated in 2004 by two scientists, Andre Geim and Konstantin (Kostya) Novoselov. (For their effort, they were awarded the Nobel Prize for physics in 2010.)

Getting back to the HBP (and the Graphene Flagship for that matter), the funding should be drying up sometime around 2023 and I wonder if it will be possible to assess the impact.

Food nanoparticles and their effect on intestinal flora (i.e., your gut microbiome)

This work from Germany is largely speculative. The scientists seem to be interested in exploring how engineered nanoparticles and naturally occurring nanoparticles in food affect your gut. From a January 29, 2019 news item on ScienceDaily,

The intestinal microbiome is not only key for food processing but an accepted codeterminant for various diseases. Researchers led by the University Medical Center of Johannes Gutenberg University Mainz (JGU) identified effects of nanoparticles on intestinal microorganisms. The ultra-small particles adhere to intestinal microorganisms, thereby affecting their life cycle as well as cross talk with the host. One of the researchers’ observations was that nanoparticles’ binding inhibits the infection with Helicobacter pylori, a pathogen implicated in gastric cancer. The findings will stimulate further epidemiological studies and pave the way for the development of potential ‘probiotic’ nanoparticles for food. The discoveries were published in Science of Food.

A January 29, 2019 Johannes Gutenberg University Mainz (JGU) press release (also on EurekAlert), which originated the news item, provides more detail,

Due to their minute size, nanoparticles have unique characteristics and capabilities, such as adhering to microstructures. Nanotechnology is as an important driver of innovation for both consumer industry and medicine. In medicine, the focus is on improving diagnostics and therapeutics, while industry addresses mainly product optimization. Hence, synthetic nanoparticles are already used as additives to improve the characteristics of food. But how can we use nanotechnology more efficiently and safely in food? And are there unknown effects of nanoparticles, which need to be further exploited?

Nutrition strongly influences the diversity and composition of our microbiome. ‘Microbiome’ describes all colonizing microorganisms present in a human being, in particular, all the bacteria in the gut. In other words, your microbiome includes your intestinal flora as well as the microorganisms that colonize your skin, mouth, and nasal cavity.

Scientists and clinicians are interested in microbiomes because of their positive or negative effects on the host. These include modulation of our immune system, metabolism, vascular aging, cerebral functioning, and our hormonal system. The composition of the microbiome seems to play an important role for the development of various disorders, such as cardiovascular diseases, cancer, allergies, obesity, and even mental disorders. “Hence, nutrition and its containing nanoparticulates may affect the microbiome-host balance, finally influencing human health. In order to reduce potential risks and, ideally, promote health, the impact of dietary nanoparticles needs to be understood,” emphasized Professor David J. McClements from the Department of Food Science at the University of Massachusetts in Amherst, USA.

“Prior to our studies, nobody really looked whether and how nano-additives directly influence the gastrointestinal flora,” commented Professor Roland Stauber of the Department of Otolaryngology, Head, and Neck Surgery at the Mainz University Medical Center. “Hence, we studied at a wide range of technical nanoparticles with clearly defined properties in order to mimic what happens to currently used or potential future nanosized food additives. By simulating the journey of particles through the different environments of the digestive tract in the laboratory, we found that the all tested nanomaterials were indeed able to bind to bacteria.” explained Stauber.

The scientists discovered that these binding processes can have different outcomes. On the one hand, nanoparticle-bound microorganisms were less efficiently recognized by the immune system, which may lead to increased inflammatory responses. On the other hand, ‘nano-food’ showed beneficial effects. In cell culture models, silica nanoparticles inhibited the infectivity of Helicobacter pylori, which is considered to be one of the main agents involved in gastric cancer.

‘It was puzzling that we were able to also isolate naturally occurring nanoparticles from food, like beer, which showed similar effects. Nanoparticles in our daily food are not just those added deliberately but can also be generated naturally during preparation. Nanoparticulates are already omnipresent,” concluded Stauber.

The insights of the study will allow to derive strategies for developing and utilizing synthetic or natural nanoparticles to modulate the microbiome as beneficial ingredients in functional foods. “The challenge is to identify nanoparticles that fit the desired purpose, perhaps even as probiotic food supplements in the future. Challenge accepted,” emphasized Stauber and his team.

Here’s a link to and a citation for the paper,

Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study by Svenja Siemer, Angelina Hahlbrock, Cecilia Vallet, David Julian McClements, Jan Balszuweit, Jens Voskuhl, Dominic Docter, Silja Wessler, Shirley K. Knauer, Dana Westmeier, & Roland H. Stauber. npj Science of Foodvolume 2, Article number: 22 (2018) DOI: https://doi.org/10.1038/s41538-018-0030-8 Published 04 December 2018

This paper is open access.

Eco-friendly nanocomposite catalyst and ultrasound to remove pollutants from water

The best part of this story is that they’re using biochar from rice hulls to create the nanocomposite catalyst. A July 19, 2019 news item on ScienceDaily reveals a few details about the research without discussing the rice hulls,

The research team of Dr. Jae-woo Choi and Dr. Kyung-won Jung of the Korea Institute of Science and Technology’s (KIST, president: Byung-gwon Lee) Water Cycle Research Center announced that it has developed a wastewater treatment process that uses a common agricultural byproduct to effectively remove pollutants and environmental hormones, which are known to be endocrine disruptors.

A July 19, 2019 Korea National Research Council of Science & Technology news release on EurekAlert, which originated the news item, provides more detail,

The sewage and wastewater that are inevitably produced at any industrial worksite often contain large quantities of pollutants and environmental hormones (endocrine disruptors). Because environmental hormones do not break down easily, they can have a significant negative effect on not only the environment but also the human body. To prevent this, a means of removing environmental hormones is required.

The performance of the catalyst that is currently being used to process sewage and wastewater drops significantly with time. Because high efficiency is difficult to achieve given the conditions, the biggest disadvantage of the existing process is the high cost involved. Furthermore, the research done thus far has mostly focused on the development of single-substance catalysts and the enhancement of their performance. Little research has been done on the development of eco-friendly nanocomposite catalysts that are capable of removing environmental hormones from sewage and wastewater.

The KIST research team, led by Dr. Jae-woo Choi and Dr. Kyung-won Jung, utilized biochar,** which is eco-friendly and made from agricultural byproducts, to develop a wastewater treatment process that effectively removes pollutants and environmental hormones. The team used rice hulls [emphasis mine] which are discarded during rice harvesting, to create a biochar that is both eco-friendly and economical. The surface of the biochar was coated with nano-sized manganese dioxide to create a nanocomposite. The high efficiency and low cost of the biochar-nanocomposite catalyst is based on the combination of the advantages of the biochar and manganese dioxide.

**Biochar: a term that collectively refers to substances that can be created through the thermal decomposition of diverse types of biomass or wood under oxygen-limited condition

The KIST team used the hydrothermal method, which is a type of mineral synthesis that uses high heat and pressure, when synthesizing the nanocomposite in order to create a catalyst that is highly active, easily replicable, and stable. It was confirmed that giving the catalyst a three-dimensional stratified structure resulted in the high effectiveness of the advanced oxidation process (AOP), due to the large surface area created.

When used under the same conditions in which the existing catalyst can remove only 80 percent of Bisphenol A (BPA), an environmental hormone, the catalyst developed by the KIST team removed over 95 percent in less than one hour. In particular, when combined with ultrasound (20kHz), it was confirmed that all traces of BPA were completely removed in less than 20 minutes. Even after many repeated tests, the BPA removal rate remained consistently at around 93 percent.

Dr. Kyung-won Jung of KIST’s Water Cycle Research Center said, “The catalyst developed through this study makes use of a common agricultural byproduct. Therefore, we expect that additional research on alternative substances will lead to the development of catalysts derived from various types of organic waste biomass.” Dr. Jae-woo Choi, also of KIST’s Water Cycle Research Center, said, “We have high hopes that future studies aimed at achieving process optimization and increasing removal rates will allow for the development an environmental hormone removal system that is both eco-friendly and low-cost.”

Here’s a link to and a citation for the paper,

Ultrasound-assisted heterogeneous Fenton-like process for bisphenol A removal at neutral pH using hierarchically structured manganese dioxide/biochar nanocomposites as catalysts by Kyung-Won Jung, Seon Yong Lee, Young Jae Lee, Jae-Woo Choi. Ultrasonics Sonochemistry
Volume 57, October 2019, Pages 22-28 DOI: https://doi.org/10.1016/j.ultsonch.2019.04.039 Available online 29 April 2019

This paper is behind a paywall.

A little digital piracy can boost bottom line for manufacturers and retailers

I’ve seen the argument before but this is the first time I’ve seen an academic supporting the thesis that digital piracy can be a boon for business. From a January 28, 2019 news item on phys.org,

HBO’s popular television series “Game of Thrones” returns in April, but millions of fans continue to illegally download the program, giving it the dubious distinction of being the most pirated program.

Many may wonder why the TV network hasn’t taken a more aggressive approach to combating illegal streaming services and downloaders. Perhaps it is because the benefits to the company outweigh the consequences. Research analysis by faculty in Indiana University’s Kelley School of Business and two other schools found that a moderate level of piracy can have a positive impact on the bottom line for both the manufacturer and the retailer—and not at the expense of consumers.

A January 28, 2019 Indiana University at Bloomington news release (also on EurekAlert), which originated the news item, expands on the theme,

“When information goods are sold to consumers via a retailer, in certain situations, a moderate level of piracy seems to have a surprisingly positive impact on the profits of the manufacturer and the retailer while, at the same time, enhancing consumer welfare,” wrote Antino Kim, assistant professor of operations and decision technologies at Kelley, and his co-authors.

“Such a win-win-win situation is not only good for the supply chain but is also beneficial for the overall economy.”

While not condoning piracy, Kim and his colleagues were surprised to find that it can actually reduce, or completely eliminate at times, the adverse effect of double marginalization, an economic concept where both manufacturers and retailers in the same supply chain add to the price of a product, passing these markups along to consumers.

The professors found that, because piracy can affect the pricing power of both the manufacturer and the retailer, it injects “shadow” competition into an otherwise monopolistic market.

“From the manufacturer’s point of view, the retailer getting squeezed is a good thing,” Kim said. “It can’t mark up the product as before, and the issue of double marginalization diminishes. Vice versa, if the manufacturer gets squeezed, the retailer is better off

“What we found is, by both of them being squeezed together — both at the upstream and the downstream levels — they are able to get closer to the optimal retail price that a single, vertically integrated entity would charge.”

In the example of “Game of Thrones,” HBO is the upstream “manufacturer” in the supply chain, and cable and satellite TV operators are the downstream “retailers.”

Kim and his co-authors — Atanu Lahiri, associate professor of information systems at the University of Texas-Dallas, and Debabrata Dey, professor of information systems at the University of Washington — presented their findings in the article, “The ‘Invisible Hand’ of Piracy: An Economic Analysis of the Information-Goods Supply Chain,” published in the latest issue of MIS Quarterly.

They suggest that businesses, government and consumers rethink the value of anti-piracy enforcement, which can be quite costly, and consider taking a moderate approach. Australia, for instance, due to prohibitive costs, scrapped its three-strikes scheme to track down illegal downloaders and send them warning notices. Though the Australian Parliament passed a new anti-piracy law last year, its effectiveness remains unclear until after it is reviewed in two years.

As with other studies, Kim and his colleagues found that when enforcement is low and piracy is rampant, both manufacturers and retailers suffer. But they caution against becoming overzealous in prosecuting illegal downloaders or in lobbying for more enforcement.

“Our results do not imply that the legal channel should, all of a sudden, start actively encouraging piracy,” they said. “The implication is simply that, situated in a real-world context, our manufacturer and retailer should recognize that a certain level of piracy or its threat might actually be beneficial and should, therefore, exercise some moderation in their anti-piracy efforts.

“This could manifest itself in them tolerating piracy to a certain level, perhaps by turning a blind eye to it,” they add. “Such a strategy would indeed be consistent with how others have described HBO’s attitude toward piracy of its products.”

This research was first made available online in August 2018, ahead of final publication in print in December 2018.

Fascinating analysis, eh?

Here’s a link to and a citation for the paper,

The “Invisible Hand” of Piracy: An Economic Analysis of the Information-Goods Supply Chain by Antino Kim, Atanu Lahiri, and Debabrata Dey. MIS Quarterly 2018 Volume 42 Issue 4: 1117-1141; DOI: 10.25300/MISQ/2018/14798

Intriguingly, for a paper about piracy someone has decided it should reside behind a paywall. However, there is an appendix which seems to be freely available here.

Iron oxide nanoparticles for artificial skin with super powers

A January 28, 2019 news item on ScienceDaily describes the possibilities for a skin replacement material,

A new type of sensor could lead to artificial skin that someday helps burn victims ‘feel’ and safeguards the rest of us, University of Connecticut researchers suggest in a paper in Advanced Materials.

Our skin’s ability to perceive pressure, heat, cold, and vibration is a critical safety function that most people take for granted. But burn victims, those with prosthetic limbs, and others who have lost skin sensitivity for one reason or another, can’t take it for granted, and often injure themselves unintentionally.

Chemists Islam Mosa from UConn [University of Connecticut], and James Rusling from UConn and UConn Health, along with University of Toronto engineer Abdelsalam Ahmed, wanted to create a sensor that can mimic the sensing properties of skin. Such a sensor would need to be able to detect pressure, temperature, and vibration. But perhaps it could do other things too, the researchers thought.

“It would be very cool if it had abilities human skin does not; for example, the ability to detect magnetic fields, sound waves, and abnormal behaviors,” said Mosa.

A January 22, 2019 UConn news release (also on EurekAlert but dated January 28, 2019), which originated the news item, give more detail about the work,

Mosa and his colleagues created such a sensor with a silicone tube wrapped in a copper wire and filled with a special fluid made of tiny particles of iron oxide just one billionth of a meter long, called nanoparticles. The nanoparticles rub around the inside of the silicone tube and create an electric current. The copper wire surrounding the silicone tube picks up the current as a signal. When this tube is bumped by something experiencing pressure, the nanoparticles move and the electric signal changes. Sound waves also create waves in the nanoparticle fluid, and the electric signal changes in a different way than when the tube is bumped.

The researchers found that magnetic fields alter the signal too, in a way distinct from pressure or sound waves. Even a person moving around while carrying the sensor changes the electrical current, and the team found they could distinguish between the electrical signals caused by walking, running, jumping, and swimming.

Metal skin might sound like a superhero power, but this skin wouldn’t make the wearer Colossus from the X-men. Rather, Mosa and his colleagues hope it could help burn victims “feel” again, and perhaps act as an early warning for workers exposed to dangerously high magnetic fields. Because the rubber exterior is completely sealed and waterproof, it could also serve as a wearable monitor to alert parents if their child fell into deep water in a pool, for example.

“The inspiration was to make something durable that would last for a very long time, and could detect multiple hazards,” Mosa says. The team has yet to test the sensor for its response to heat and cold, but they suspect it will work for those as well. The next step is to make the sensor in a flat configuration, more like skin, and see if it still works.

Here’s a link to and a citation for the paper,

An Ultra‐Shapeable, Smart Sensing Platform Based on a Multimodal Ferrofluid‐Infused Surface by Abdelsalam Ahmed, Islam Hassan, Islam M. Mosa, Esraa Elsanadidy, Mohamed Sharafeldin, James F. Rusling, Shenqiang Ren. Advanced Materials DOI: https://doi.org/10.1002/adma.201807201 First published: 28 January 2019

This paper is behind a paywall.

Analyzing a buckyball’s (buckminsterfullerene) quantum structure

The work was done jointly by the US National Institute of Standards and Technology (NIST) and JILA (Joint Institute for Laboratory Astrophysics), which is operated ‘jointly’ by NIST and the University of Colorado. On to buckyballs, a nickname for buckminsterfullerenes or C60.

From a January 28, 2019 news item on ScienceDaily,

JILA researchers have measured hundreds of individual quantum energy levels in the buckyball, a spherical cage of 60 carbon atoms. It’s the largest molecule that has ever been analyzed at this level of experimental detail in the history of quantum mechanics. Fully understanding and controlling this molecule’s quantum details could lead to new scientific fields and applications, such as an entire quantum computer contained in a single buckyball.

Caption: JILA researchers used frequency combs, or “rulers of light,” to observe individual quantum energy transitions in buckyballs. Credit: Steven Burrows/JILA

There are two types of spherical objects in the image: the smooth blue ones, which are not buckyballs, and the ones with ridged spheres, which are.

A January 28, 2019 NIST news release (also on EurekAlert), which originated the news item, describes the buckyball molecule and the research in more detail,

The buckyball, formally known as buckminsterfullerene, is extremely complex. Due to its enormous 60-atom size, the overall molecule has a staggeringly high number of ways to vibrate–at least 100,000,000,000,000,000,000,000,000 vibrational quantum states when the molecule is warm. That’s in addition to the many different energy states for the buckyball’s rotation and other properties.

As described in the January 4 [2019] issue of Science, the JILA team used an updated version of their frequency comb spectroscopy and cryogenic buffer gas cooling system to observe isolated, individual energy transitions among rotational and vibrational states in cold, gaseous buckyballs. This is the first time anyone has been able to prepare buckyballs in this form to analyze its rotations and vibrations at the quantum level.

JILA is jointly operated by the National Institute of Standards and Technology (NIST) and the University of Colorado Boulder.

Buckyballs, first discovered in 1984, have created great scientific excitement. But high-resolution spectroscopy, which can reveal the details of the molecule’s rotational and vibrational properties, didn’t work at ordinary room temperatures because the signals were too congested, NIST/JILA Fellow Jun Ye said. Low temperatures (about -138 degrees Celsius, which is -216 degrees Fahrenheit) enabled researchers to concentrate the molecules into a single rotational-vibrational quantum state at the lowest energy level and probe them with high-resolution spectroscopy.

The buckyball is the most symmetric molecule known, with a soccer-ball-like shape known as a modified icosahedron. It is small enough to be fully understood with basic quantum mechanics principles. Yet it is large enough to reveal insights into the extreme quantum complexity that emerges in huge systems.

As an example of practical applications, buckyballs could act as a pristine network of 60 atoms. The core of each atom possesses an identical property known as “nuclear spin,” which enables it to interact magnetically with its environment. Therefore, each spin could act as a magnetically controlled quantum bit or “qubit” in a quantum computer.

“If we had a buckyball made of pure isotopic carbon-13, each atom would have a nuclear spin of 1/2, and each buckyball could serve as a 60-qubit quantum computer,” Ye said. “Of course, we don’t have such capabilities yet; we would need to first capture these buckyballs in traps.”

A key part of the new quantum revolution, a quantum computer using qubits made of atoms or other materials could potentially solve important problems that are intractable using today’s machines. NIST has a major stake in quantum science

“There are also a lot of astrophysics connections,” Ye continued. “There are abundant buckyball signals coming from remote carbon stars,” so the new data will enable scientists to better understand the universe.

After they measured the quantum energy levels, the JILA researchers collected statistics on buckyballs’ nuclear spin values. They confirmed that all 60 atoms were indistinguishable, or virtually identical. Precise measurements of the buckyball’s transition energies between individual quantum states revealed its atoms interacted strongly with one another, providing insights into the complexities of its molecular structure and the forces between atoms.

For the experiments, an oven converted a solid sample of material into gaseous buckyballs. These hot molecules flowed into a cell (container) anchored to a cryogenic cold apparatus, such that the molecules were cooled by collisions with cold argon gas atoms. Then laser light at precise frequencies was aimed at the cold gas molecules, and researchers measured how much light was absorbed. The observed structure in the infrared spectrum encoded details of the quantum-mechanical energy-level structure.

The laser light was produced by an optical frequency comb, or “ruler of light,” and aimed into an optical cavity surrounding the cold cell to enhance the absorption signals. The comb contained about 1000 “teeth” at optical frequencies spanning the full band of buckyball vibrations. The comb light was generated from a single fiber laser.

Here’s a link to and a citation for the paper,

Rovibrational quantum state resolution of the C60 fullerene by P. Bryan Changala, Marissa L. Weichman, Kevin F. Lee, Martin E. Fermann, Jun Ye1. Science 04 Jan 2019: Vol. 363, Issue 6422, pp. 49-54 DOI: 10.1126/science.aav2616

This paper appears to be open access.

Harvesting the heart’s kinetic energy to power implants

This work comes from Dartmouth College, an educational institution based on the US east coast in the state of New Hampshire. I hardly ever stumble across research from Dartmouth and I assume that’s because they usually focus their interests in areas that are not of direct interest to me,

Rendering of the two designs of the cardiac energy harvesting device. (Cover art by Patricio Sarzosa) Courtesy: Dartmouth College

For a change, we have a point of connection (harvesting biokinetic energy) according to a February 4, 2019 news item on ScienceDaily,

The heart’s motion is so powerful that it can recharge devices that save our lives, according to new research from Dartmouth College.

Using a dime-sized invention developed by engineers at the Thayer School of Engineering at Dartmouth, the kinetic energy of the heart can be converted into electricity to power a wide-range of implantable devices, according to the study funded by the National Institutes of Health.

A February 4, 2019 Dartmouth College news release, which originated the news item, describes the problem and the proposed solution,

Millions of people rely on pacemakers, defibrillators and other live-saving implantable devices powered by batteries that need to be replaced every five to 10 years. Those replacements require surgery which can be costly and create the possibility of complications and infections.

“We’re trying to solve the ultimate problem for any implantable biomedical device,” says Dartmouth engineering professor John X.J. Zhang, a lead researcher on the study his team completed alongside clinicians at the University of Texas in San Antonio. “How do you create an effective energy source so the device will do its job during the entire life span of the patient, without the need for surgery to replace the battery?”

“Of equal importance is that the device not interfere with the body’s function,” adds Dartmouth research associate Lin Dong, first author on the paper. “We knew it had to be biocompatible, lightweight, flexible, and low profile, so it not only fits into the current pacemaker structure but is also scalable for future multi-functionality.”

The team’s work proposes modifying pacemakers to harness the kinetic energy of the lead wire that’s attached to the heart, converting it into electricity to continually charge the batteries. The added material is a type of thin polymer piezoelectric film called “PVDF” and, when designed with porous structures — either an array of small buckle beams or a flexible cantilever — it can convert even small mechanical motion to electricity. An added benefit: the same modules could potentially be used as sensors to enable data collection for real-time monitoring of patients.

The results of the three-year study, completed by Dartmouth’s engineering researchers along with clinicians at UT Health San Antonio, were just published in the cover story for Advanced Materials Technologies.

The two remaining years of NIH funding plus time to finish the pre-clinical process and obtain regulatory approval puts a self-charging pacemaker approximately five years out from commercialization, according to Zhang

“We’ve completed the first round of animal studies with great results which will be published soon,” says Zhang. “There is already a lot of expressed interest from the major medical technology companies, and Andrew Closson, one of the study’s authors working with Lin Dong and an engineering PhD Innovation Program student at Dartmouth, is learning the business and technology transfer skills to be a cohort in moving forward with the entrepreneurial phase of this effort.”

Other key collaborators on the study include Dartmouth engineering professor Zi Chen, an expert on thin structure mechanics, and Dr. Marc Feldman, professor and clinical cardiologist at UT [University of Texas] Health San Antonio.

Here’s a citation and another link for the paper,

Energy Harvesting: Flexible Porous Piezoelectric Cantilever on a Pacemaker Lead for Compact Energy Harvesting by Lin Dong, Xiaomin Han, Zhe Xu, Andrew B. Closson, Yin Liu, Chunsheng Wen, Xi Liu, Gladys Patricia Escobar, Meagan Oglesby, Marc Feldman, Zi Chen, John X. J. Zhang. Adv. Mater. Technol. 1/2019 https://doi.org/10.1002/admt.201970002 First published: 08 January 2019

This paper is open access.

Structure of tunneling nanotubes (TNTs) challenges the dogma of the cell

There is a video that accompanies the news but I strongly advise reading the press release first, unless you already know a lot about cells and tunneling nanotubes.

A January 30, 2019 Institut Pasteur press release (also on EurekAlert but published Jan.31, 2019) announces the work,

Cells in our bodies have the ability to speak with one another much like humans do. This communication allows organs in our bodies to work synchronously, which in turn, enables us to perform the remarkable range of tasks we meet on a daily basis. One of this mean of communication is ‘tunneling nanotubes’ or TNTs. In an article published in Nature Communications, researchers from the Institut Pasteur leaded by Chiara Zurzolo discovered, thanks to advanced imaging techniques, that the structure of these nanotubes challenged the very concept of cell.

As their name implies, TNTs are tiny tunnels that link two (or more cells) and allow the transport of a wide variety of cargoes between them, including ions, viruses, and entire organelles. Previous research by the same team (Membrane Traf?c and Pathogenesis Unit) at the Institut Pasteur have shown that TNTs are involved in the intercellular spreading of pathogenic amyloid proteins involved in Alzheimer and Parkinson’s disease. This led researchers to propose that they serve as a major avenue for the spreading of neurodegenerative diseases in the brain and therefore represent a novel therapeutic target to stop the progression of these incurable diseases. TNTs also appear to play a major role in cancer resistance to therapy. But as scientists still know very little about TNTs and how they relate or differ from other cellular protrusions such as filopodia, they decided to pursue their research to deal with these tiny tubular connections in depth.

The dogma of cell unit questioned

A better understanding of these tiny tubular connections is therefore required as TNTs might have tremendous implications in human health and disease. Addressing this issue has been very difficult due to the fragile and transitory nature of these structures, which do not survive classical microscopic techniques. In order to overcome these obstacles, researchers combined various state-of-the-art electron microscopy approaches, and imaged TNTs at below-freezing temperatures.

Using this imaging strategy, researchers were able to decipher the structure of TNTs in high detail. Specifically, they show that most TNTs – previously shown to be single connections – are in fact made up of multiple, smaller, individual tunneling nanotubes (iTNTs). Their images also show the existence of thin wires that connect iTNTs, which could serve to increase their mechanical stability. They demonstrate the functionality of iTNTs by showing the transport of organelles using time-lapse imaging. Finally, researchers employed a type of microscopy known as ‘FIB-SEM’ to produce 3D images with sufficient resolution to clearly identify that TNTs are ‘open’ at both ends, and thus create continuity between two cells. “This discovery challenges the dogma of cells as individual units, showing that cells can open up to neighbors and exchange materials without a membrane barrier” explains Chiara Zurzolo, head of the Membrane Traf?c and Pathogenesis Unit at the Institut Pasteur.

A news step in cell-to-cell communication decoding

By applying an imaging work-flow that improves upon, and avoids, previous limitations of tools used to study the anatomy of TNTs, researchers provide the first structural description of TNTs. Importantly, they provide the absolute demonstration that these are novel cellular organelles with a defined structure, very different from known cell protrusions. “The description of the structure allows the understanding of the mechanisms involved in their formation and provides a better comprehension of their function in transferring material directly between (the cytosol of) two connected cells” says Chiara Zurzolo. Furthermore, their strategy, which preserves these delicate structures, will be useful for studying the role TNTs play in other physiological and pathological conditions

This work is an essential step toward understanding cell-to-cell communication via TNTs and lays the groundwork for investigations into their physiological functions and their role in spreading of particles linked to diseases such as viruses, bacteria, and misfolded proteins.

The researchers have kindly produced a version of the video in English,

Here’s a link to and a citation for the paper,

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells by Anna Sartori-Rupp, Diégo Cordero Cervantes, Anna Pepe, Karine Gousset, Elise Delage, Simon Corroyer-Dulmont, Christine Schmitt, Jacomina Krijnse-Locker & Chiara Zurzolo. Nature Communications volume 10, Article number: 342 (2019) DOI https://doi.org/10.1038/s41467-018-08178-7 Published 21 January 2019

This paper is open access.

Elder care robot being tested by Washington State University team

I imagine that at some point the Washington State University’s (WSU) ‘elder care’ robot will be tested by senior citizens as opposed to the students described in a January 14, 2019 WSU news release (also on EurekAlert) by Will Ferguson,

A robot created by Washington State University scientists could help elderly people with dementia and other limitations live independently in their own homes.

The Robot Activity Support System, or RAS, uses sensors embedded in a WSU smart home to determine where its residents are, what they are doing and when they need assistance with daily activities.

It navigates through rooms and around obstacles to find people on its own, provides video instructions on how to do simple tasks and can even lead its owner to objects like their medication or a snack in the kitchen.

“RAS combines the convenience of a mobile robot with the activity detection technology of a WSU smart home to provide assistance in the moment, as the need for help is detected,” said Bryan Minor, a postdoctoral researcher in the WSU School of Electrical Engineering and Computer Science.

Minor works in the lab of Diane Cook, professor of electrical engineering and computer science and director of the WSU Center for Advanced Studies in Adaptive Systems.

For the last decade, Cook and Maureen Schmitter-Edgecombe, a WSU professor of psychology, have led CASAS researchers in the development of smart home technologies that could enable elderly adults with memory problems and other impairments to live independently.

Currently, an estimated 50 percent of adults over the age of 85 need assistance with every day activities such as preparing meals and taking medication and the annual cost for this assistance in the US is nearly $2 trillion.

With the number of adults over 85 expected to triple by 2050, Cook and Schmitter-Edgecombe hope that technologies like RAS and the WSU smart home will alleviate some of the financial strain on the healthcare system by making it easier for older adults to live alone.

“Upwards of 90 percent of older adults prefer to age in place as opposed to moving into a nursing home,” Cook said. “We want to make it so that instead of bringing in a caregiver or sending these people to a nursing home, we can use technology to help them live independently on their own.”

RAS is the first robot CASAS researchers have tried to incorporate into their smart home environment. They recently published a study in the journal Cognitive Systems Research that demonstrates how RAS could make life easier for older adults struggling to live independently

In the study CASAS researchers recruited 26 undergraduate and graduate students [emphasis mine] to complete three activities in a smart home with RAS as an assistant.

The activities were getting ready to walk the dog, taking medication with food and water and watering household plants.

When the smart home sensors detected a human failed to initiate or was struggling with one of the tasks, RAS received a message to help.

The robot then used its mapping and navigation camera, sensors and software to find the person and offer assistance.

The person could then indicate through a tablet interface that they wanted to see a video of the next step in the activity they were performing, a video of the entire activity or they could ask the robot to lead them to objects needed to complete the activity like the dog’s leash or a granola bar from the kitchen.

Afterwards the study participants were asked to rate the robot’s performance. Most of the participants rated RAS’ performance favorably and found the robot’s tablet interface to be easy to use. They also reported the next step video as being the most useful of the prompts.

“While we are still in an early stage of development, our initial results with RAS have been promising,” Minor said. “The next step in the research will be to test RAS’ performance with a group of older adults to get a better idea of what prompts, video reminders and other preferences they have regarding the robot.”

Here’s a link to and a citation for the paper,

Robot-enabled support of daily activities in smart home environment by Garrett Wilson, Christopher Pereyda, Nisha Raghunath, Gabriel de la Cruz, Shivam Goel, Sepehr Nesaei, Bryan Minor, Maureen Schmitter-Edgecombe, Matthew E.Taylor, Diane J.Cook. Cognitive Systems Research Volume 54, May 2019, Pages 258-272 DOI: https://doi.org/10.1016/j.cogsys.2018.10.032

This paper is behind a paywall.

Other ‘caring’ robots

Dutch filmmaker, Sander Burger, directed a documentary about ‘caredroids’ for seniors titled ‘Alice Cares’ or ‘Ik ben Alice’ in Dutch. It premiered at the 2015 Vancouver (Canada) International Film Festival and was featured in a January 22, 2015 article by Neil Young for the Hollywood Reporter,


The benign side of artificial intelligence enjoys a rare cinematic showcase in Sander Burger‘s Alice Cares (Ik ben Alice), a small-scale Dutch documentary that reinvents no wheels but proves as unassumingly delightful as its eponymous, diminutive “care-robot.” Touching lightly on social and technological themes that are increasingly relevant to nearly all industrialized societies, this quiet charmer bowed at Rotterdam ahead of its local release and deserves wider exposure via festivals and small-screen outlets.

… Developed by the US firm Hanson Robotics, “Alice”— has the stature and face of a girl of eight, but an adult female’s voice—is primarily intended to provide company for lonely seniors.

Burger shows Alice “visiting” the apartments of three octogenarian Dutch ladies, the contraption overcoming their hosts’ initial wariness and quickly forming chatty bonds. This prototype “care-droid” represents the technology at a relatively early stage, with Alice unable to move anything apart from her head, eyes (which incorporate tiny cameras) and mouth. Her body is made much more obviously robotic in appearance than the face, to minimize the chances of her interlocutors mistaking her for an actual human. Such design-touches are discussed by Alice’s programmer in meetings with social-workers, which Burger and his editor Manuel Rombley intersperses between the domestic exchanges that provide the bulk of the running-time.

‘Alice’ was also featured in the Lancet’s (a general medical journal) July 18, 2015 article by Natalie Harrison,

“I’m going to ask you some questions about your life. Do you live independently? Are you lonely?” If you close your eyes and start listening to the film Alice Cares, you would think you were overhearing a routine conversation between an older woman and a health-care worker. It’s only when the woman, Martha Remkes, ends the conversation with “I don’t feel like having a robot in my home, I prefer a human being” that you realise something is amiss. In the Dutch documentary Alice Cares, Alice Robokind, a prototype caredroid developed in a laboratory in Amsterdam, is sent to live with three women who require care and company, with rather surprising results

Although the idea of health robots has been around for a couple of decades, research into the use of robots with older adults is a fairly new area. Alex Mihailidis, from the Intelligent Assistive Technology and Systems Lab [University of Toronto] in Toronto, ON, Canada, explains: “For carers, robots have been used as tools that can help to alleviate burden typically associated with providing continuous care”. He adds that “as robots become more viable and are able to perform common physical tasks, they can be very valuable in helping caregivers complete common tasks such as moving a person in and out of bed”. Although Japan and Korea are regarded as the world leaders in this research, the European Union and the USA are also making progress. At the Edinburgh Centre for Robotics, for example, researchers are working to develop more complex sensor and navigation technology for robots that work alongside people and on assisted living prosthetics technologies. This research is part of a collaboration between the University of Edinburgh and Heriot-Watt University that was awarded £6 million in funding as part of a wider £85 million investment into industrial technology in the UK Government’s Eight Great Technologies initiative. Robotics research is clearly flourishing and the global market for service and industrial robots is estimated to reach almost US$60 billion by 2020.

The idea for Alice Cares came to director Sander Burger after he read about a group of scientists at the VU University of Amsterdam in the Netherlands who were about to test a health-care robot on older people. “The first thing I felt was some resentment against the idea—I was curious why I was so offended by the whole idea and just called the scientists to see if I could come by to see what they were doing. …

… With software to generate and regulate Alice’s emotions, an artificial moral reasoner, a computational model of creativity, and full access to the internet, the investigators hoped to create a robotic care provider that was intelligent, sensitive, creative, and entertaining. “The robot was specially developed for social skills, in short, she was programmed to make the elderly women feel less lonely”, explains Burger.

Copyright © 2015 Alice Cares KeyDocs

Both the Young and Harrison articles are well worth the time, should you have enough to read them. Also, there’s an Ik ben Alice website (it’s in Dutch only).

Meanwhile, Canadians can look at Humber River Hospital (HHR; Toronto, Ontario) for a glimpse at another humanoid ‘carebot’, from a July 25, 2018 HHR Foundation blog entry,

Earlier this year, a special new caregiver joined the Child Life team at the Humber River Hospital. Pepper, the humanoid robot, helps our Child Life Specialists decrease patient anxiety, increase their comfort and educate young patients and their families. Pepper embodies perfectly the intersection of compassion and advanced technology for which Humber River is renowned.

Pepper helps our Child Life Specialists decrease patient anxiety, increase their comfort and educate young patients.

Humber River Hospital is committed to making the hospital experience a better one for our patients and their families from the moment they arrive and Pepper the robot helps us do that! Pepper is child-sized with large, expressive eyes and a sweet voice. It greets visitors, provides directions, plays games, does yoga and even dances. Using facial recognition to detect human emotions, it adapts its behaviour according to the mood of the person with whom it’s interacting. Pepper makes the Hospital an even more welcoming place for everyone it encounters.

Humber currently has two Peppers on staff: one is used exclusively by the Child Life Program to help young patients feel at ease and a second to greet patients and their families in the Hospital’s main entrance.

While Pepper robots are used around the world in such industries as retail and hospitality, Humber River is the first hospital in Canada to use Pepper in a healthcare setting. Using dedicated applications built specifically for the Hospital, Pepper’s interactive touch-screen display helps visitors find specific departments, washrooms, exits and more. In addition to answering questions and sharing information, Pepper entertains, plays games and is always available for a selfie.

I’m guessing that they had a ‘soft’ launch for Pepper because there’s an Oct. 25, 2018 HHR news release announcing Pepper’s deployment,

Pepper® can greet visitors, provide directions, play games, do yoga and even dance

Humber River Hospital has joined forces with SoftBank Robotics America (SBRA) to launch a new pilot program with Pepper the humanoid robot.  Beginning this week, Pepper will greet, help guide, engage and entertain patients and visitors who enter the hospital’s main entrance hall.

“While the healthcare sector has talked about this technology for some time now, we are ambitious and confident at Humber River Hospital to make the move and become the first hospital in Canada to pilot this technology,” states Barbara Collins, President and CEO, Humber River Hospital. 


Pepper by the numbers:
Stands 1.2 m (4ft) tall and weighs 29 kg (62lb)
Features three cameras – two 2 HD cameras and one 3D depth sensor – to “see” and interact with people
20 engines in Pepper’s head, arms and back control its precise movements
A 10-inch chest-mounted touchscreen tablet that Pepper uses to convey information and encourage input

Finally, there’s a 2012 movie, Robot & Frank (mentioned here before in this Oct. 13, 2017 posting; scroll down to Robots and pop culture subsection) which provides an intriguing example of how ‘carebots’ might present unexpected ethical challenges. Hint: Frank is a senior citizen and former jewel thief who decides to pass on some skills.

Final thoughts

It’s fascinating to me that every time I’ve looked at articles about robots being used for tasks usually performed by humans that some expert or other sweetly notes that robots will be used to help humans with tasks that are ‘boring’ or ‘physical’ with the implication that humans will focus on more rewarding work, from Harrison’s Lancet article (in a previous excerpt),

… Alex Mihailidis, from the Intelligent Assistive Technology and Systems Lab in Toronto, ON, Canada, explains: “For carers, robots have been used as tools that can help to alleviate burden typically associated with providing continuous care”. He adds that “as robots become more viable and are able to perform common physical tasks, they can be very valuable in helping caregivers …

For all the emphasis on robots as taking over burdensome physical tasks, Burger’s documentary makes it clear that these early versions are being used primarily to provide companionship. Yes, HHR’s Pepper® is taking over some repetitive tasks, such as giving directions, but it’s also playing and providing companionship.

As for what it will mean ultimately, that’s something we, as a society, need to consider.