Category Archives: economics

Math + data + history lead to cliodynamics and history crisis detection

This February 18, 2024 essay by Daniel Hoyer, senior researcher, historian, and complexity scientist at the University of Toronto for The Conversation, discuses history as scientific data, Note: Links have been removed,

American humorist and writer Mark Twain is believed to have once said, “History doesn’t repeat itself, but it often rhymes.”

I’ve been working as a historian and complexity scientist for the better part of a decade, and I often think about this phrase as I follow different strands of the historical record and notice the same patterns over and over.

My background is in ancient history. As a young researcher, I tried to understand why the Roman Empire became so big and what ultimately led to its downfall. Then, during my doctoral studies, I met the evolutionary biologist turned historian Peter Turchin, and that meeting had a profound impact on my work.

I joined Turchin and a few others who were establishing a new field – a new way to investigate history. It was called cliodynamics after Clio, the ancient Greek muse of history, and dynamics, the study of how complex systems change over time. Cliodynamics marshals scientific and statistical tools to better understand the past.

The aim is to treat history as a “natural” science, using statistical methods, computational simulations and other tools adapted from evolutionary theory, physics and complexity science to understand why things happened the way that they did.

By turning historical knowledge into scientific “data”, we can run analyses and test hypotheses about historical processes, just like any other science.

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Hoyer’s essay is fascinating and I can’t really do it justice with a few excerpts but hopefully these will tempt you into reading more of his and his colleagues’ work, from the February 18, 2024 essay.

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Since 2011, my colleagues and I have been compiling an enormous amount of information about the past and storing it in a unique collection called the Seshat: Global History Databank. Seshat involves the contribution of over 100 researchers from around the world.

We create structured, analysable information by surveying the huge amount of scholarship available about the past. For instance, we can record a society’s population as a number, or answer questions about whether something was present or absent. Like, did a society have professional bureaucrats? Or, did it maintain public irrigation works.

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Our goal is to find out what drove these societies into crisis, and then what factors seem to have determined whether people could course-correct to stave off devastation.

But why? Right now, we are living in an age of polycrisis – a state where social, political, economic, environmental and other systems are not only deeply interrelated, but nearly all of them are under strain or experiencing some kind of disaster or extreme upheaval.

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Pouring through the historical record, we have started noticing some very important themes rhyming through history. Even major ecological disasters and unpredictable climates are nothing new.

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One of the most common patterns that has jumped out is how extreme inequality shows up in nearly every case of major crisis. When big gaps exist between the haves and have-nots, not just in material wealth but also access to positions of power, this breeds frustration, dissent and turmoil.

“Ages of discord”, as Turchin dubbed periods of great social unrest and violence, produce some of history’s most devastating events. This includes the US civil war of the 1860s, the early 20th-century Russian Revolution, and the Taiping rebellion against the Chinese Qing dynasty, often said to be the deadliest civil war in history.

All of these cases saw people become frustrated at extreme wealth inequality, along with lack of inclusion in the political process. Frustration bred anger, and eventually erupted into fighting that killed millions and affected many more.

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Perhaps one of the most surprising things is that inequality seems to be just as corrosive for the elites themselves. This is because the accumulation of so much wealth and power leads to intense infighting between them, which ripples throughout society.

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My colleague, political scientist Jack Goldstone, came up with a theory to explain this [“gap between the wealthy who can afford services and the growing number who cannot”] in the early 1990s, called structural demographic theory. He took an in-depth look at the French Revolution, often seen as the archetypal popular revolt. Goldstone was able to show that a lot of the fighting and grievances were driven by frustrated elites, not only by the “masses”, as is the common understanding.

These elites were finding it harder and harder to get a seat at the table with the French royal court. Goldstone noted that the reason these tensions became so inflamed and exploded is because the state had been losing its grip on the country for decades due to mismanagement of resources and from all of the entrenched privileges that the elites were fighting so hard to retain.

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If the past teaches us anything, it is that trying to hold on to systems and policies that refuse to appropriately adapt and respond to changing circumstances — like climate change or growing unrest among a population – usually end in disaster. Those with the means and opportunity to enact change must do so, or at least to not stand in the way when reform is needed.

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Our goal as cliodynamicists is to uncover patterns – not just to see how what we are doing today rhymes with the past – but to help find better ways forward.

If you have the time, please do read Hoyer’s February 18, 2024 essay in its entirety (h/t February 19, 2024 news item on phys.org). The Seshat Global History Databank can be found here.

The 2023 Canadian federal budget: science & technology of health, the clean economy, reconciliation, and more (1 of 2)

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The Canadian federal government released its 2023 budget on Tuesday, March 28, 2023. There were no flashy science research announcements in the budget. Trudeau and his team like to trumpet science initiatives and grand plans (even if they’re reannouncing something from a previous budget) but like last year—this year—not so much.

Consequently, this posting about the annual federal budget should have been shorter than usual. What happened?

Partly, it’s the military spending (chapter 5 of the budget in part 2 of this 2023 budget post). For those who are unfamiliar with the link between military scientific research and their impact on the general population, there are a number of inventions and innovations directly due to military research, e.g., plastic surgery, television, and the internet. (You can check a November 6, 2018 essay for The Conversation by Robert Kirby, Professor of Clinical Education and Surgery at Keele University, for more about the impact of World War 1 and medical research, “World War I: the birth of plastic surgery and modern anaesthesia.”)

So, there’s a lot to be found by inference. Consequently, I found Chapter 3 to also be unexpectedly rich in science and technology efforts.

Throughout both parts of this 2023 Canadian federal budget post, you will find excerpts from individual chapters of the federal budget followed my commentary directly after. My general commentary is reserved for the end.

Sometimes, I have included an item because it piqued my interest. E.g., Canadian agriculture is dependent on Russian fertilizer!!! News to me and I imagine many others. BTW, this budget aims to wean us from this dependency.

Chapter 2: Investing in Public Health Care and Affordable Dental Care

Here goes: from https://www.budget.canada.ca/2023/report-rapport/toc-tdm-en.html,

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2.1 Investing in Public Health Care
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Improving Canada’s Readiness for Health Emergencies
Vaccines and other cutting-edge life-science innovations have helped us to take control of the COVID-19 pandemic. To support these efforts, the federal government has committed significant funding towards the revitalization of Canada’s biomanufacturing sector through a Biomanufacturing and Life Sciences Strategy [emphasis mine]. To date, the government has invested more than $1.8 billion in 32 vaccine, therapeutic, and biomanufacturing projects across Canada, alongside $127 million for upgrades to specialized labs at universities across the country. Canada is building a life sciences ecosystem that is attracting major investments from leading global companies, including Moderna, AstraZeneca, and Sanofi.
To build upon the progress of the past three years, the government will explore new ways to be more efficient and effective in the development and production of the vaccines, therapies, and diagnostic tools that would be required for future health emergencies. As a first step, the government will further consult Canadian and international experts on how to best organize our readiness efforts for years to come. …

Gold rush in them thar life sciences

I have covered the rush to capitalize on Canadian life sciences research (with a special emphasis on British Columbia) in various posts including (amongst others): my December 30, 2020 posting “Avo Media, Science Telephone, and a Canadian COVID-19 billionaire scientist,” and my August 23, 2021 posting “Who’s running the life science companies’ public relations campaign in British Columbia (Vancouver, Canada)?” There’s also my August 20, 2021 posting “Getting erased from the mRNA/COVID-19 story,” highlighting how brutal the competition amongst these Canadian researchers can be.

Getting back to the 2023 budget, ‘The Biomanufacturing and Life Sciences Strategy’ mentioned in this latest budget was announced in a July 28, 2021 Innovation, Science and Economic Development Canada news release. You can find the strategy here and an overview of the strategy here. You may want to check out the overview as it features links to,

What We Heard Report: Results of the consultation on biomanufacturing and life sciences capacity in Canada
Ontario’s Strategy: Taking life sciences to the next level
Quebec’s Strategy: 2022–2025 Québec Life Sciences Strategy
Nova Scotia’s Strategy: BioFuture2030 Prince Edward Island’s Strategy:
The Prince Edward Island Bioscience Cluster [emphases mine]

2022 saw one government announcement concerning the strategy, from a March 3, 2022 Innovation, Science and Economic Development Canada news release, Note: Links have been removed,

Protecting the health and safety of Canadians and making sure we have the domestic capacity to respond to future health crises are top priorities of the Government of Canada. With the guidance of Canada’s Biomanufacturing and Life Sciences Strategy, the government is actively supporting the growth of a strong, competitive domestic life sciences sector, with cutting-edge biomanufacturing capabilities.
Today [March 3, 2022], the Honourable François-Philippe Champagne, Minister of Innovation, Science and Industry, announced a $92 million investment in adMare BioInnovations to drive company innovation, scale-up and training activities in Canada’s life sciences sector. This investment will help translate commercially promising health research into innovative new therapies and will see Canadian anchor companies provide the training required and drive the growth of Canada’s life science companies.
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The real action took place earlier this month (March 2023) just prior to the budget. Oddly, I can’t find any mention of these initiatives in the budget document. (Confession: I have not given the 2023 budget a close reading although I have been through the whole budget once and viewed individual chapters more closely a few times.)

This March 2, 2023 (?) Tri-agency Institutional Programs Secretariat news release kicked things off, Note 1: I found the date at the bottom of their webpage; Note 2: Links have been removed,

The Government of Canada’s main priority continues to be protecting the health and safety of Canadians. Throughout the pandemic, the quick and decisive actions taken by the government meant that Canada was able to scale up domestic biomanufacturing capacity, which had been in decline for over 40 years. Since then, the government is rebuilding a strong and competitive biomanufacturing and life sciences sector brick by brick. This includes strengthening the foundations of the life sciences ecosystem through the research and talent of Canada’s world-class postsecondary institutions and research hospitals, as well as fostering increased collaboration with innovative companies.
Today [March 2, 2023?], the Honourable François-Philippe Champagne, Minister of Innovation, Science and Industry, and the Honourable Jean-Yves Duclos, Minister of Health, announced an investment of $10 million in support of the creation of five research hubs [emphasis mine]:

CBRF PRAIRIE Hub, led by the University of Alberta
Canada’s Immuno-Engineering and Biomanufacturing Hub, led by The University of British Columbia
Eastern Canada Pandemic Preparedness Hub, led by the Université de Montréal
Canadian Pandemic Preparedness Hub, led by the University of Ottawa and McMaster University
Canadian Hub for Health Intelligence & Innovation in Infectious Diseases, led by the University of Toronto

This investment, made through Stage 1 of the integrated Canada Biomedical Research Fund (CBRF) and Biosciences Research Infrastructure Fund (BRIF) competition, will bolster research and talent development efforts led by the institutions, working in collaboration with their partners. The hubs combine the strengths of academia, industry and the public and not-for-profit sectors to jointly improve pandemic readiness and the overall health and well-being of Canadians.
The multidisciplinary research hubs will accelerate the research and development of next-generation vaccines and therapeutics and diagnostics, while supporting training and development to expand the pipeline of skilled talent. The hubs will also accelerate the translation of promising research into commercially viable products and processes. This investment helps to strengthen the resilience of Canada’s life sciences sector by supporting leading Canadian research in innovative technologies that keep us safe and boost our economy.
Today’s [March 2, 2023?] announcement also launched Stage 2 of the CBRF-BRIF competition. This is a national competition that includes $570 million in available funding for proposals, aimed at cutting-edge research, talent development and research infrastructure projects associated with the selected research hubs. By strengthening research and talent capacity and leveraging collaborations across the entire biomanufacturing ecosystem, Canada will be better prepared to face future pandemics, in order to protect Canadian’s health and safety.

Then, the Innovation, Science and Economic Development Canada’s March 9, 2023 news release made this announcement, Note: Links have been removed,

Since March 2020, major achievements have been made to rebuild a vibrant domestic life sciences ecosystem to protect Canadians against future health threats. The growth of the sector is a top priority for the Government of Canada, and with over $1.8 billion committed to 33 projects to boost our domestic biomanufacturing, vaccine and therapeutics capacity, we are strengthening our resiliency for current health emergencies and our readiness for future ones.
The COVID-19 Vaccine Task Force played a critical role in guiding and supporting the Government of Canada’s COVID-19 vaccine response. Today [March 9, 2023], recognizing the importance of science-based decisions, the Honourable François-Philippe Champagne, Minister of Innovation, Science and Industry, and the Honourable Jean-Yves Duclos, Minister of Health, are pleased to announce the creation of the Council of Expert Advisors (CEA). The 14 members of the CEA, who held their first official meeting earlier this week, will advise the Government of Canada on the long-term, sustainable growth of Canada’s biomanufacturing and life sciences sector, and on how to enhance our preparedness and capacity to protect the health and safety of Canadians.
The membership of the CEA comprises leaders with in-depth scientific, industrial, academic and public health expertise. The CEA co-chairs are Joanne Langley, Professor of Pediatrics and of Community Health and Epidemiology at the Dalhousie University Faculty of Medicine, and Division Head of Infectious Diseases at the IWK Health Centre; and Marco Marra, Professor in Medical Genetics at the University of British Columbia (UBC), UBC Canada Research Chair in Genome Science and distinguished scientist at the BC Cancer Foundation.
The CEA’s first meeting focused on the previous steps taken under Canada’s Biomanufacturing and Life Sciences Strategy and on its path forward. The creation of the CEA is an important milestone in the strategy, as it continues to evolve and adapt to new technologies and changing conditions in the marketplace and life sciences ecosystem. The CEA will also inform on investments that enhance capacity across Canada to support end-to-end production of critical vaccines, therapeutics and essential medical countermeasures, and to ensure that Canadians can reap the full economic benefits of the innovations developed, including well-paying jobs.

As I’m from British Columbia, I’m highlighting this University of British Columbia (UBC) March 17, 2023 news release about their involvement, Note: Links have been removed,

Canada’s biotech ecosystem is poised for a major boost with the federal government announcement today that B.C. will be home to Canada’s Immuno-Engineering and Biomanufacturing Hub (CIEBH).
The B.C.-based research and innovation hub, led by UBC, brings together a coalition of provincial, national and international partners to position Canada as a global epicentre for the development and manufacturing of next-generation immune-based therapeutics.
A primary goal of CIEBH is to establish a seamless drug development pipeline that will enable Canada to respond to future pandemics and other health challenges in fewer than 100 days.
This hub will build on the strengths of B.C.’s biotech and life sciences industry, and those of our national and global partners, to make Canada a world leader in the development of lifesaving medicines,” said Dr. Deborah Buszard, interim president and vice-chancellor of UBC. “It’s about creating a healthier future for all Canadians. Together with our outstanding alliance of partners, we will ensure Canada is prepared to respond rapidly to future health challenges with homegrown solutions.”
CIEBH is one of five new research hubs announced by the federal government that will work together to improve pandemic readiness and the overall health and well-being of Canadians. Federal funding of $570 million is available over the next four years to support project proposals associated with these hubs in order to advance Canada’s Biomanufacturing and Life Sciences Strategy.
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More than 50 organizations representing the private, public, not-for-profit and academic sectors have come together to form the hub, creating a rich environment that will bolster biomedical innovation in Canada. Among these partners are leading B.C. biotech companies that played a key role in Canada’s COVID-19 pandemic response and are developing cutting-edge treatments for a range of human diseases.
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CIEBH, led by UBC, will further align the critical mass of biomedical research strengths concentrated at B.C. academic institutions, including the B.C. Institute of Technology, Simon Fraser University and the University of Victoria, as well as the clinical expertise of B.C. research hospitals and health authorities. With linkages to key partners across Canada, including Dalhousie University, the University of Waterloo, and the Vaccine and Infectious Disease Organization, the hub will create a national network to address gaps in Canada’s drug development pipeline.
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In recent decades, B.C. has emerged as a global leader in immuno-engineering, a field that is transforming how society treats disease by harnessing and modulating the immune system.
B.C. academic institutions and prominent Canadian companies like Precision NanoSystems, Acuitas Therapeutics and AbCellera have developed significant expertise in advanced immune-based therapeutics such as lipid nanoparticle- and mRNA-based vaccines, engineered antibodies, cell therapies and treatments for antimicrobial resistant infections. UBC professor Dr. Pieter Cullis, a member of CIEBH’s core scientific team, has been widely recognized for his pioneering work developing the lipid nanoparticle delivery technology that enables mRNA therapeutics such as the highly effective COVID-19 mRNA vaccines.
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As noted previously, I’m a little puzzled that the federal government didn’t mention the investment in these hubs in their budget. They usually trumpet these kinds of initiatives.

On a related track, I’m even more puzzled that the province of British Columbia does not have its own life sciences research strategy in light of that sector’s success. Certainly it seems that Ontario, Quebec, Nova Scotia, and Prince Edward are all eager to get a piece of the action. Still, there is a Life Sciences in British Columbia: Sector Profile dated June 2020 and an undated (likely from some time between July 2017 to January 2020 when Bruce Ralston whose name is on the document was the relevant cabinet minister) British Columbia Technology and Innovation Policy Framework.

In case you missed the link earlier, see my August 23, 2021 posting “Who’s running the life science companies’ public relations campaign in British Columbia (Vancouver, Canada)?” which includes additional information about the BC life sciences sector, federal and provincial funding, the City of Vancouver’s involvement, and other related matters.

Chapter 3: A Made-In-Canada Plan: Affordable Energy, Good Jobs, and a Growing Clean Economy

The most science-focused information is in Chapter 3, from https://www.budget.canada.ca/2023/report-rapport/toc-tdm-en.html,

3.2 A Growing, Clean Economy
More than US$100 trillion in private capital is projected to be spent between now and 2050 to build the global clean economy.
Canada is currently competing with the United States, the European Union, and countries around the world for our share of this investment. To secure our share of this global investment, we must capitalize on Canada’s competitive advantages, including our skilled and diverse workforce, and our abundance of critical resources that the world needs.
The federal government has taken significant action over the past seven years to support Canada’s net-zero economic future. To build on this progress and support the growth of Canada’s clean economy, Budget 2023 proposes a range of measures that will encourage businesses to invest in Canada and create good-paying jobs for Canadian workers.
This made-in-Canada plan follows the federal tiered structure to incent the development of Canada’s clean economy and provide additional support for projects that need it. This plan includes:

Clear and predictable investment tax credits to provide foundational support for clean technology manufacturing, clean hydrogen, zero-emission technologies, and carbon capture and storage;
The deployment of financial instruments through the Canada Growth Fund, such as contracts for difference, to absorb certain risks and encourage private sector investment in low-carbon projects, technologies, businesses, and supply chains; and,
Targeted clean technology and sector supports delivered by Innovation, Science and Economic Development Canada to support battery manufacturing and further advance the development, application, and manufacturing of clean technologies.

Canada’s Potential in Critical Minerals
As a global leader in mining, Canada is in a prime position to provide a stable resource base for critical minerals [emphasis mine] that are central to major global industries such as clean technology, auto manufacturing, health care, aerospace, and the digital economy. For nickel and copper alone, the known reserves in Canada are more than 10 million tonnes, with many other potential sources at the exploration stage.
The Buy North American provisions for critical minerals and electric vehicles in the U.S. Inflation Reduction Act will create opportunities for Canada. In particular, U.S. acceleration of clean technology manufacturing will require robust supply chains of critical minerals that Canada has in abundance. However, to fully unleash Canada’s potential in critical minerals, we need to ensure a framework is in place to accelerate private investment.
Budget 2022 committed $3.8 billion for Canada’s Critical Minerals Strategy to provide foundational support to Canada’s mining sector to take advantage of these new opportunities. The Strategy was published in December 2022.
On March 24, 2023, the government launched the Critical Minerals Infrastructure Fund [emphasis mine; I cannot find a government announcement/news release for this fund]—a new fund announced in Budget 2022 that will allocate $1.5 billion towards energy and transportation projects needed to unlock priority mineral deposits. The new fund will complement other clean energy and transportation supports, such as the Canada Infrastructure Bank and the National Trade Corridors Fund, as well as other federal programs that invest in critical minerals projects, such as the Strategic Innovation Fund.
The new Investment Tax Credit for Clean Technology Manufacturing proposed in Budget 2023 will also provide a significant incentive to boost private investment in Canadian critical minerals projects and create new opportunities and middle class jobs in communities across the country.
An Investment Tax Credit for Clean Technology Manufacturing
Supporting Canadian companies in the manufacturing and processing of clean technologies, and in the extraction and processing of critical minerals, will create good middle class jobs for Canadians, ensure our businesses remain competitive in major global industries, and support the supply chains of our allies around the world.
While the Clean Technology Investment Tax Credit, first announced in Budget 2022, will provide support to Canadian companies adopting clean technologies, the Clean Technology Manufacturing Investment Tax Credit will provide support to Canadian companies that are manufacturing or processing clean technologies and their precursors.

Budget 2023 proposes a refundable tax credit equal to 30 per cent of the cost of investments in new machinery and equipment used to manufacture or process key clean technologies, and extract, process, or recycle key critical minerals, including:
- Extraction, processing, or recycling of critical minerals essential for clean technology supply chains, specifically: lithium, cobalt, nickel, graphite, copper, and rare earth elements;
- Manufacturing of renewable or nuclear energy equipment;
- Processing or recycling of nuclear fuels and heavy water; [emphases mine]
- Manufacturing of grid-scale electrical energy storage equipment;
- Manufacturing of zero-emission vehicles; and,
- Manufacturing or processing of certain upstream components and materials for the above activities, such as cathode materials and batteries used in electric vehicles.

The investment tax credit is expected to cost $4.5 billion over five years, starting in 2023-24, and an additional $6.6 billion from 2028-29 to 2034-35. The credit would apply to property that is acquired and becomes available for use on or after January 1, 2024, and would no longer be in effect after 2034, subject to a phase-out starting in 2032.
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3.4 Reliable Transportation and Resilient Infrastructure
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Supporting Resilient Infrastructure Through Innovation
The Smart Cities Challenge [emphasis mine] was launched in 2017 to encourage cities to adopt new and innovative approaches to improve the quality of life for their residents. The first round of the Challenge resulted in $75 million in prizes across four winning applicants: Montreal, Quebec; Guelph, Ontario; communities of Nunavut; and Bridgewater, Nova Scotia.
New and innovative solutions are required to help communities reduce the risks and impacts posed by weather-related events and disasters triggered by climate change. To help address this issue, the government will be launching a new round of the Smart Cities Challenge later this year, which will focus on using connected technologies, data, and innovative approaches to improve climate resiliency.
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3.5 Investing in Tomorrow’s Technology
With the best-educated workforce on earth, world-class academic and research institutions, and robust start-up ecosystems across the country, Canada’s economy is fast becoming a global technology leader – building on its strengths in areas like artificial intelligence. Canada is already home to some of the top markets for high-tech careers in North America, including the three fastest growing markets between 2016 and 2021: Vancouver, Toronto, and Quebec City.
However, more can be done to help the Canadian economy reach its full potential. Reversing a longstanding trend of underinvestment in research and development by Canadian business [emphasis mine] is essential our long-term economic growth.
Budget 2023 proposes new measures to encourage business innovation in Canada, as well as new investments in college research and the forestry industry that will help to build a stronger and more innovative Canadian economy.
Attracting High-Tech Investment to Canada
In recent months, Canada has attracted several new digital and high-tech projects that will support our innovative economy, including:

Nokia: a $340 million project that will strengthen Canada’s position as a leader in 5G and digital innovation;
Xanadu Quantum Technologies: a $178 million project that will support Canada’s leadership in quantum computing;
Sanctuary Cognitive Systems Corporation: a $121 million project that will boost Canada’s leadership in the global Artificial Intelligence market; and,
EXFO: a $77 million project to create a 5G Centre of Excellence that aims to develop one of the world’s first Artificial Intelligence-based automated network solutions.

Review of the Scientific Research and Experimental Development Tax Incentive Program
The Scientific Research and Experimental Development (SR&ED) tax incentive program continues to be a cornerstone of Canada’s innovation strategy by supporting research and development with the goal of encouraging Canadian businesses of all sizes to invest in innovation that drives economic growth.
In Budget 2022, the federal government announced its intention to review the SR&ED program to ensure it is providing adequate support and improving the development, retention, and commercialization of intellectual property, including the consideration of adopting a patent box regime. [emphasis mine] The Department of Finance will continue to engage with stakeholders on the next steps in the coming months.
Modernizing Canada’s Research Ecosystem
Canada’s research community and world-class researchers solve some of the world’s toughest problems, and Canada’s spending on higher education research and development, as a share of GDP, has exceeded all other G7 countries.
Since 2016, the federal government has committed more than $16 billion of additional funding to support research and science across Canada. This includes:

Nearly $4 billion in Budget 2018 for Canada’s research system, including $2.4 billion for the Canada Foundation for Innovation and the granting councils—the Natural Sciences and Engineering Research Council of Canada, the Social Sciences and Humanities Research Council of Canada and the Canadian Institutes of Health Research; [emphases mine]
More than $500 million in Budget 2019 in total additional support to third-party research and science organizations, in addition to the creation of the Strategic Science Fund, which will announce successful recipients later this year;
$1.2 billion in Budget 2021 for Pan-Canadian Genomics and Artificial Intelligence Strategies, and a National Quantum Strategy;
$1 billion in Budget 2021 to the granting councils and the Canada Foundation for Innovation for life sciences researchers and infrastructure; and,
The January 2023 announcement of Canada’s intention to become a full member in the Square Kilometre Array Observatory, which will provide Canadian astronomers with access to its ground-breaking data. The government is providing up to $269.3 million to support this collaboration.

In order to maintain Canada’s research strength—and the knowledge, innovations, and talent it fosters—our systems to support science and research must evolve. The government has been consulting with stakeholders, including through the independent Advisory Panel on the Federal Research Support System, to seek advice from research leaders on how to further strengthen Canada’s research support system.
The government is carefully considering the Advisory Panel’s advice, with more detail to follow in the coming months on further efforts to modernize the system.
Using College Research to Help Businesses Grow
Canada’s colleges, CEGEPs, and polytechnic institutes use their facilities, equipment, and expertise to solve applied research problems every day. Students at these institutions are developing the skills they need to start good careers when they leave school, and by partnering with these institutions, businesses can access the talent and the tools they need to innovate and grow.

To help more Canadian businesses access the expertise and research and development facilities they need, Budget 2023 proposes to provide $108.6 million over three years, starting in 2023-24, to expand the College and Community Innovation Program, administered by the Natural Sciences and Engineering Research Council.

Supporting Canadian Leadership in Space
For decades, Canada’s participation in the International Space Station has helped to fuel important scientific advances, and showcased Canada’s ability to create leading-edge space technologies, such as Canadarm2. Canadian space technologies have inspired advances in other fields, such as the NeuroArm, the world’s first robot capable of operating inside an MRI, making previously impossible surgeries possible.

Budget 2023 proposes to provide $1.1 billion [emphasis mine] over 14 years, starting in 2023-24, on a cash basis, to the Canadian Space Agency [emphasis mine] to continue Canada’s participation in the International Space Station until 2030.

Looking forward, humanity is returning to the moon [emphasis mine]. Canada intends to join these efforts by contributing a robotic lunar utility vehicle to perform key activities in support of human lunar exploration. Canadian participation in the NASA-led Lunar Gateway station—a space station that will orbit the moon—also presents new opportunities for innovative advances in science and technology. Canada is providing Canadarm3 to the Lunar Gateway, and a Canadian astronaut will join Artemis II, the first crewed mission to the moon since 1972. In Budget 2023, the government is providing further support to assist these missions.

Budget 2023 proposes to provide $1.2 billion [emphasis mine] over 13 years, starting in 2024-25, to the Canadian Space Agency to develop and contribute a lunar utility vehicle to assist astronauts on the moon.
Budget 2023 proposes to provide $150 million [emphasis mine[ over five years, starting in 2023-24, to the Canadian Space Agency for the next phase of the Lunar Exploration Accelerator Program to support the Canada’s world-class space industry and help accelerate the development of new technologies.
Budget 2023 also proposes to provide $76.5 million [emphasis mine] over eight years, starting in 2023-24, on a cash basis, to the Canadian Space Agency in support of Canadian science on the Lunar Gateway station.

Investing in Canada’s Forest Economy
The forestry sector plays an important role in Canada’s natural resource economy [emphasis mine], and is a source of good careers in many rural communities across Canada, including Indigenous communities. As global demand for sustainable forest products grows, continued support for Canada’s forestry sector will help it innovate, grow, and support good middle class jobs for Canadians.

Budget 2023 proposes to provide $368.4 million over three years, starting in 2023-24, with $3.1 million in remaining amortization, to Natural Resources Canada to renew and update forest sector support, including for research and development, Indigenous and international leadership, and data. Of this amount, $30.1 million would be sourced from existing departmental resources.

Establishing the Dairy Innovation and Investment Fund
The dairy sector is facing a growing surplus of solids non-fat (SNF) [emphasis mine], a by-product of dairy processing. Limited processing capacity for SNF results in lost opportunities for dairy processors and farmers.

Budget 2023 proposes to provide $333 million over ten years, starting in 2023-24, for Agriculture and Agri-Food Canada to support investments in research and development of new products based on SNF, market development for these products, and processing capacity for SNF-based products more broadly.

Supporting Farmers for Diversifying Away from Russian Fertilizers
Russia’s illegal invasion of Ukraine has resulted in higher prices for nitrogen fertilizers, which has had a notable impact on Eastern Canadian farmers who rely heavily on imported fertilizer.

Budget 2023 proposes to provide $34.1 million over three years, starting in 2023-24, to Agriculture and Agri-Food Canada’s On-Farm Climate Action Fund to support adoption of nitrogen management practices by Eastern Canadian farmers, that will help optimize the use and reduce the need for fertilizer.

Providing Interest Relief for Agricultural Producers
Farm production costs have increased in Canada and around the world, including as a result Russia’s illegal invasion of Ukraine and global supply chain disruptions. It is important that Canada’s agricultural producers have access to the cash flow they need to cover these costs until they sell their products.

Budget 2023 proposes to provide $13 million in 2023-24 to Agriculture and Agri-Food Canada to increase the interest-free limit for loans under the Advance Payments Program from $250,000 to $350,000 for the 2023 program year.

Additionally, the government will consult with provincial and territorial counterparts to explore ways to extend help to small agricultural producers who demonstrate urgent financial need.
Maintaining Livestock Sector Exports with a Foot-and-Mouth Disease Vaccine Bank
Foot-and-Mouth Disease (FMD) is a highly transmissible illness that can affect cattle, pigs, and other cloven-hoofed animals. Recent outbreaks in Asia and Africa have increased the risk of global spread, and a FMD outbreak in Canada would cut off exports for all livestock sectors, with major economic implications. However, the impact of a potential outbreak would be significantly reduced with the early vaccination of livestock.

Budget 2023 proposes to provide $57.5 million over five years, starting in 2023-24, with $5.6 million ongoing, to the Canadian Food Inspection Agency to establish a FMD vaccine bank for Canada, and to develop FMD response plans. The government will seek a cost-sharing arrangement with provinces and territories.

Canadian economic theory (the staples theory), mining, nuclear energy, quantum science, and more

Critical minerals are getting a lot of attention these days. (They were featured in the 2022 budget, see my April 19, 2022 posting, scroll down to the Mining subhead.) This year, US President Joe Biden, in his first visit to Canada as President, singled out critical minerals at the end of his 28 hour state visit (from a March 24, 2023 CBC news online article by Alexander Panetta; Note: Links have been removed),

There was a pot of gold at the end of President Joe Biden’s jaunt to Canada. It’s going to Canada’s mining sector.
The U.S. military will deliver funds this spring to critical minerals projects in both the U.S. and Canada. The goal is to accelerate the development of a critical minerals industry on this continent.
The context is the United States’ intensifying rivalry with China.
The U.S. is desperate to reduce its reliance on its adversary for materials needed to power electric vehicles, electronics and many other products, and has set aside hundreds of millions of dollars under a program called the Defence Production Act.
The Pentagon already has told Canadian companies they would be eligible to apply. It has said the cash would arrive as grants, not loans.
On Friday [March 24, 2023], before Biden left Ottawa, he promised they’ll get some.
The White House and the Prime Minister’s Office announced that companies from both countries will be eligible this spring for money from a $250 million US fund.
Which Canadian companies? The leaders didn’t say. Canadian officials have provided the U.S. with a list of at least 70 projects that could warrant U.S. funding.
…
“Our nations are blessed with incredible natural resources,” Biden told Canadian parliamentarians during his speech in the House of Commons.
“Canada in particular has large quantities of critical minerals [emphasis mine] that are essential for our clean energy future, for the world’s clean energy future.
…

I don’t believe that Joe Biden has ever heard of the Canadian academic Harold Innis (neither have most Canadians) but Biden is echoing a rather well known theory, in some circles, about Canada’s economy (from the Harold Innis Wikipedia entry),

Harold Adams Innis FRSC (November 5, 1894 – November 9, 1952) was a Canadian professor of political economy at the University of Toronto and the author of seminal works on media, communication theory, and Canadian economic history. He helped develop the staples thesis, which holds that Canada’s culture, political history, and economy have been decisively influenced by the exploitation and export of a series of “staples” such as fur, fish, lumber, wheat, mined metals, and coal. The staple thesis dominated economic history in Canada from the 1930s to 1960s, and continues to be a fundamental part of the Canadian political economic tradition.^[8] [all emphases mine]
…

The staples theory is referred to informally as “hewers of wood and drawers of water.”

Critical Minerals Infrastructure Fund

I cannot find an announcement for this fund (perhaps it’s a US government fund?) but there is a March 7, 2023 Natural Resources Canada news release, Note: A link has been removed,

…
Simply put, our future depends on critical minerals. The Government of Canada is committed to investing in this future, which is why the Canadian Critical Minerals Strategy — launched by the Honourable Jonathan Wilkinson, Minister of Natural Resources, in December 2022 — is backed by up to $3.8 billion in federal funding. [emphases mine] Today [March 7, 2023], Minister Wilkinson announced more details on the implementation of this Strategy. Over $344 million in funding is supporting the following five new programs and initiatives:

Critical Minerals Technology and Innovation Program – $144.4 million for the research, development, demonstration, commercialization and adoption of new technologies and processes that support sustainable growth in Canadian critical minerals value chains and associated innovation ecosystems.
Critical Minerals Geoscience and Data Initiative – $79.2 million to enhance the quality and availability of data and digital technologies to support geoscience and mapping that will accelerate the efficient and effective development of Canadian critical minerals value chains, including by identifying critical minerals reserves and developing pathways for sustainable mineral development.
Global Partnerships Program – $70 million to strengthen Canada’s global leadership role in enhancing critical minerals supply chain resiliency through international collaborations related to critical minerals.
Northern Regulatory Initiative – $40 million to advance Canada’s northern and territorial critical minerals agenda by supporting regulatory dialogue, regional studies, land-use planning, impact assessments and Indigenous consultation.
Renewal of the Critical Minerals Centre of Excellence (CMCE) – $10.6 million so the CMCE can continue the ongoing development and implementation of the Canadian Critical Minerals Strategy.

Commentary from the mining community

Mariaan Webb wrote a March 29,2023 article about the budget and the response from the mining community for miningweekly.com, Note: Links have been removed,

The 2023 Budget, delivered by Finance Minister Chrystia Freeland on Tuesday, bolsters the ability of the Canadian mining sector to deliver for the country, recognising the industry’s central role in enabling the transition to a net-zero economy, says Mining Association of Canada (MAC) president and CEO Pierre Gratton.
“Without mining, there are no electric vehicles, no clean power from wind farms, solar panels or nuclear energy, [emphasis mine] and no transmission lines,” said Gratton.
…

What kind of nuclear energy?

There are two kinds of nuclear energy: fission and fusion. (Fission is the one where the atom is split and requires minerals. Fusion energy is how stars are formed. Much less polluting than fission energy, at this time it is not a commercially viable option nor is it close to being so.)

As far as I’m aware, fusion energy does not require any mined materials. So, Gratton appears to be referring to fission nuclear energy when he’s talking about the mining sector and critical minerals.

I have an October 28, 2022 posting, which provides an overview of fusion energy and the various projects designed to capitalize on it.

Smart Cities in Canada

I was happy to be updated on the Smart Cities Challenge. When I last wrote about it (a March 20, 2018 posting; scroll down to the “Smart Cities, the rest of the country, and Vancouver” subhead). I notice that the successful applicants are from Montreal, Quebec; Guelph, Ontario; communities of Nunavut; and Bridgewater, Nova Scotia. It’s about time northern communities got some attention. It’s hard not to notice that central Canada (i.e., Ontario and Quebec) again dominates.

I look forward to hearing more about the new, upcoming challenge.

The quantum crew

I first made note of what appears to be a fracture in the Canadian quantum community in a May 4, 2021 posting (scroll down to the National Quantum Strategy subhead) about the 2021 budget. I made note of it again in a July 26, 2022 posting (scroll down to the Canadian quantum scene subhead).

In my excerpts from the 3.5 Investing in Tomorrow’s Technology section of the 2023 budget, Xanadu Quantum Technologies, headquartered in Toronto, Ontario is singled out with three other companies (none of which are in the quantum computing field). Oddly, D-Wave Systems (located in British Columbia), which as far as I’m aware is the star of Canada’s quantum computing sector, has yet to be singled out in any budget I’ve seen yet. (I’m estimating I’ve reviewed about 10 budgets.)

Canadians in space

Shortly after the 2023 budget was presented, Canadian astronaut Jeremy Hansen was revealed as one of four astronauts to go on a mission to orbit the moon. From a Canadian Broadcasting (CBC) April 3, 2023 news online article by Nicole Mortillaro (Note: A link has been removed),

Jeremy Hansen is heading to the moon.
The 47-year old Canadian astronaut was announced today as one of four astronauts — along with Christina Koch, Victor Glover and Reid Wiseman — who will be part of NASA’s [US National Aeronautics and Space Administration] Artemis II mission.
…
Hansen was one of four active Canadian astronauts that included Jennifer Sidey-Gibbons, Joshua Kutryk and David Saint-Jacques vying for a seat on the Orion spacecraft set to orbit the moon.
…
Artemis II is the second step in NASA’s mission to return astronauts to the surface of the moon.
The astronauts won’t be landing, but rather they will orbit for 10 days in the Orion spacecraft, testing key components to prepare for Artemis III that will place humans back on the moon some time in 2025 for the first time since 1972.
Canada gets a seat on Artemis II due to its contributions to Lunar Gateway, a space station that will orbit the moon. But Canada is also building a lunar rover provided by Canadensys Aerospace.
…
On Monday [April 3, 2023], Hansen noted there are two reasons a Canadian is going to the moon, adding that it “makes me smile when I say that.”
The first, he said, is American leadership, and the decision to curate an international team.
“The second reason is Canada’s can-do attitude,” he said proudly.
…

In addition to our ‘can-do attitude,” we’re also spending some big money, i.e., the Canadian government has proposed in its 2023 budget some $2.5B to various space and lunar efforts over the next several years.

Chapter 3 odds and sods

First seen in the 2022 budget, the patent box regime makes a second appearance in the 2023 budget where apparently ‘stakeholders will be engaged’ later this year. At least, they’re not rushing into this. (For the original announcement and an explanation of a patent box regime, see my April 19, 2022 budget review; scroll down to the Review of Tax Support to R&D and Intellectual Property subhead.)

I’m happy to see the Dairy Innovation and Investment Fund. I’m particularly happy to see a focus on finding uses for solids non-fat (SNF) by providing “$333 million over ten years, starting in 2023-24, … research and development of new products based on SNF [emphasis mine], market development for these products, and processing capacity for SNF-based products more broadly.”

This investment contrasts with the approach to cellulose nanocrystals (CNC) derived from wood (i.e., the forest economy), where the Canadian government invested heavily in research and even opened a production facility under the auspices of a company, CelluForce. It was a little problematic.

By 2013, the facility had a stockpile of CNC and nowhere to sell it. That’s right, no market for CNC as there had been no product development. (See my May 8, 2012 posting where that lack is mentioned, specifically there’s a quote from Tim Harper in an excerpted Globe and Mail article. My August 17, 2016 posting notes that the stockpile was diminishing. The CelluForce website makes no mention of it now in 2023.)

It’s good to see the government emphasis on research into developing products for SNFs especially after the CelluForce stockpile and in light of US President Joe Biden’s recent enthusiasm over our critical minerals.

Chapter 4: Advancing Reconciliation and Building a Canada That Works for Everyone

Chapter 4: Advancing Reconciliation and Building a Canada That Works for Everyone offers this, from https://www.budget.canada.ca/2023/report-rapport/toc-tdm-en.html,

4.3 Clean Air and Clean Water
…
Progress on Biodiversity
Montreal recently hosted the Fifteenth Conference of the Parties (COP15) to the United Nations Convention on Biological Diversity, which led to a new Post-2020 Global Biodiversity Framework. During COP15, Canada announced new funding for biodiversity and conservation measures at home and abroad that will support the implementation of the Global Biodiversity Framework, including $800 million to support Indigenous-led conservation within Canada through the innovative Project Finance for Permanence model.
Protecting Our Freshwater
Canada is home to 20 per cent of the world’s freshwater supply. Healthy lakes and rivers are essential to Canadians, communities, and businesses across the country. Recognizing the threat to freshwater caused by climate change and pollution, the federal government is moving forward to establish a new Canada Water Agency and make major investments in a strengthened Freshwater Action Plan.

Budget 2023 proposes to provide $650 million over ten years, starting in 2023-24, to support monitoring, assessment, and restoration work in the Great Lakes, Lake Winnipeg, Lake of the Woods, St. Lawrence River, Fraser River, Saint John River, Mackenzie River, and Lake Simcoe. Budget 2023 also proposes to provide $22.6 million over three years, starting in 2023-24, to support better coordination of efforts to protect freshwater across Canada.
Budget 2023 also proposes to provide $85.1 million over five years, starting in 2023-24, with $0.4 million in remaining amortization and $21 million ongoing thereafter to support the creation of the Canada Water Agency [emphasis mine], which will be headquartered in Winnipeg. By the end of 2023, the government will introduce legislation that will fully establish the Canada Water Agency as a standalone entity.

…
Cleaner and Healthier Ports
Canada’s ports are at the heart of our supply chains, delivering goods to Canadians and allowing our businesses to reach global markets. As rising shipping levels enable and create economic growth and good jobs, the federal government is taking action to protect Canada’s coastal ecosystems and communities.

Budget 2023 proposes to provide $165.4 million over seven years, starting in 2023-24, to Transport Canada to establish a Green Shipping Corridor Program to reduce the impact of marine shipping on surrounding communities and ecosystems. The program will help spur the launch of the next generation of clean ships, invest in shore power technology, and prioritize low-emission and low-noise vessels at ports.

Water, water everywhere

I wasn’t expecting to find mention of establishing a Canada Water Agency and details are sketchy other than, It will be in Winnipeg, Manitoba and there will be government funding. Fingers crossed that this agency will do some good work (whatever that might be). Personally, I’d like to see some action with regard to droughts.

In British Columbia (BC) where I live and which most of us think of as ‘water rich’, is suffering under conditions such that our rivers and lakes are at very low levels according to an April 6, 2023 article by Glenda Luymes for the Vancouver Sun (print version, p. A4),

…
On the North American WaterWatch map, which codes river flows using a series of coloured dots, high flows are represented in various shades of blue while low flows are represented in red hues. On Wednesday [April 5, 2023], most of BC was speckled red, brown and orange, with the majority of the province’s rivers flowing “much below normal.”
“It does not bode well for the fish populations,” said Marvin Rosenau, a fisheries and ecosystems instructor at BCIT [British Columbia Institute of Technology]. …
Rosenau said low water last fall [2022], when much of BC was in the grip of drought, decreased salmon habitat during spawning season. …
…
BC has already seen small early season wildfires, including one near Merritt last weekend [April 1/2, 2023]. …

Getting back to the Canada Water Agency, there’s this March 29, 2023 CBC news online article by Bartley Kives,

The 2023 federal budget calls for a new national water agency to be based in Winnipeg, provided Justin Trudeau’s Liberal government remains in power long enough to see it established [emphasis mine] in the Manitoba capital.
The budget announced on Tuesday [March 28, 2023] calls for the creation of the Canada Water Agency, a new federal entity with a headquarters in Winnipeg.
While the federal government is still determining precisely what the new agency will do, one Winnipeg-based environmental organization expects it to become a one-stop shop for water science, water quality assessment and water management [emphasis mine].
“This is something that we don’t actually have in this country at the moment,” said Matt McCandless, a vice-president for the non-profit International Institute for Sustainable Development.
Right now, municipalities, provinces and Indigenous authorities take different approaches to managing water quality, water science, flooding and droughts, said McCandless, adding a national water agency could provide more co-ordination.
…
For now, it’s unknown how many employees will be based at the Canada Water Agency’s Winnipeg headquarters. According to the budget, legislation to create the agency won’t be introduced until later this year [emphasis mine].
That means the Winnipeg headquarters likely won’t materialize before 2024, one year before the Trudeau minority government faces re-election, assuming it doesn’t lose the confidence of the House of Commons beforehand [emphasis mine].
Nonetheless, several Canadian cities and provinces were vying for the Canada Water Agency’s headquarters, including Manitoba.
…
The budget also calls for $65 million worth of annual spending on lake science and restoration, with an unstated fraction of that cash devoted to Lake Winnipeg.
McCandless calls the spending on water science an improvement over previous budgets.
…

Kives seems a tad jaundiced but you get that way (confession: I have too) when covering government spending promises.

Part 2 (military spending and general comments) will be posted sometime during the week of April 24-28, 2023.

Gene therapy in Canada; a November 2020 report and two events in December 2020

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There’s a lot of action, albeit quiet and understated, in the Canadian gene therapy ‘discussion’. One major boost to the discussion was the Nov. 3, 2020 release of a report by the Canadian Council of Academies (CCA), “From Research to Reality; The Expert Panel on the Approval and Use of Somatic Gene Therapies in Canada.”

Dec. 2 – 3, 2020 Breaking Through

Another boost is the the free and virtual, upcoming 2020 Gairdner Ontario International Symposium “Breaking Through: Delivering on the Promise of Gene Therapy“; an international symposium on gene therapy research and practice, which will feature a presentation on the CCA’s report,

Breaking Through brings together Canadian and international leaders to explore the past, present, and future of somatic gene therapy research and practice. This two-day virtual event will examine the successes, challenges and opportunities from the bench to the bedside. It will also feature:

Speaker sessions from Canadian and international researchers at the forefront of gene therapy research.
A panel discussion exploring the opportunities and challenges facing Canadian scientists, regulators, clinicians, decision-makers, and patients (Presented by NRC).
A presentation and Expert Panel discussion on the Council of Canadian Academies’ latest report, From Research to Reality, and a closing panel discussion about the future of gene therapies and gene editing (Presented by Genome Canada).

The title for the CCA report bears an uncanny resemblance to the name for a Canadian initiative highlighting science research, Research2Reality (R2R). (If you’re curious, you can check out my past postings on R2R by using ‘Research2Reality’ as the term for the blog’s search engine.

Glybera

This name stood out: Michael Hayden (scroll down to his name and click), one of the featured speakers for this Dec. 2 – 3, 2020 event, reminded me of the disturbing Glybera story,

…
Dr. Hayden identified the first mutations underlying lipoprotein lipase (LPL) deficiency and developed gene therapy approaches to treat this condition, the first approved gene therapy (Glybera) in the western world.
…

Kelly Crowe’s Nov. 17, 2018 story for the Canadian Broadcasting Corporation (CBC) lays it out,

It is one of this country’s great scientific achievements.
The first drug ever approved that can fix a faulty gene.
It’s called Glybera, and it can treat a painful and potentially deadly genetic disorder with a single dose — a genuine made-in-Canada medical breakthrough.
But most Canadians have never heard of it.
A team of researchers at the University of British Columbia spent decades developing the treatment for people born with a genetic mutation that causes lipoprotein lipase defficiency (LPLD).
…

If you have the time, do read Crowe’s Nov. 17, 2018 story but as I warned in another post, it’s heartbreaking.

Fora brief summary, the company which eventually emerged with the licensing rights to Glybera, charged $1m per dose and a single dose is good for 10 years. It seems governments are reluctant to approve the cost and for many individuals, it’s an impossible price to meet, every 10 years. So, the drug is dead. Or perhaps not? Take a look at the symposium’s agenda (scroll down) for description,

GLYBERA REINVENTED: A WINDING STORY OF COMMITMENT, CREATIVITY, AND INNOVATION
Michael Hayden, MB, ChB, PhD, FRCP(C), FRSC, C.M., O.B.C University Killam Professor, Senior Scientist, Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics,
University of British Columbia (Vancouver, BC)

Money issues

One theme from the agenda jumped out at me: money. The focus seems to be largely on accessibility and costs. The Nov. 3, 2020 CCA news release (also on EurekAlert) about the report also prominently featured costs,

Gene therapies are being approved for use in Canada, but could strain healthcare budgets and exacerbate existing treatment inequities [emphasis mine] across the country. However, there are opportunities to control spending, streamline approvals and support fair access through innovation, coordination and collaboration, according to a new expert panel report from the Council of Canadian Academies (CCA).
“Rapid scientific advances mean potentially life-changing treatments are approaching the clinic at an accelerated pace,” said Janet Rossant, PhD, C.C., FRSC, and Chair of the Expert Panel. “These new therapies, however, pose a number of challenges in terms of their introduction into the Canadian healthcare system and ensuring access to those who would most benefit.”
…

Gene therapies and gene editing

Before moving on, you might find it useful to know (if you don’t already) that gene therapy can be roughly divided into somatic cell gene therapy and germline gene therapy as per the Gene Therapy entry in Wikipedia.

Two other items on the symposium’s agenda (scroll down) drew my attention,

Genome editing and the promise for future therapies
Ronald Cohn, MD, FACMG, FCAHS President and CEO,
The Hospital for Sick Children (SickKids) (Toronto, ON)
…
COMING SOON: THE FUTURE OF GENE EDITING AND GENE THERAPIES
Presented by: Genome Canada
Rob Annan, PhD President and CEO,
Genome Canada (Ottawa, ON)
R. Alta Charo, J.D. Warren P. Knowles Professor of Law & Bioethics,
University of Wisconsin Law School (Madison, USA)
Jay Ingram, C.M. Science broadcaster and writer, Former Co-Host, Discovery Channel’s “Daily Planet” (Calgary, AB)
Vardit Ravitsky, PhD, FCAHS Full Professor, Bioethics Program, Department of Social and Preventative Medicine, School of Public Health, Université de Montréal; President, International Association of Bioethics (Montréal, QC)
Janet Rossant, PhD, C.C., FRSC President,
Gairdner Foundation (Toronto, ON) [also a member of the CCA expert panel for report on somatic cell therapies ‘From research to reality …’)

Genome editing, by the way and if you don’t know, is also known as gene editing. The presence of the word ‘future’ in both the presentations has my antennae quivering. Could they be hinting at germline editing possibilities? At this time, the research is illegal in Canada.

If you don’t happen to know, somatic gene editing, covered in the CCA report, does not affect future generations as opposed to germline gene editing, which does. Should you be curious about the germline gene editing discussion in Canada, I covered as much information as I could uncover in an April 26, 2019 posting on topic.

Jay Ingram’s presence on the panel sponsored by Genome Canada is a bit of a surprise.

I saw him years ago as the moderator for a panel presentation sponsored by Genome British Columbia. The discussion was about genetics and ethics, which was illustrated by clips from the television programme, ReGenesis (from its IMDB entry),

[Fictional] Geneticist David Sandstrom is the chief scientist at the prestigious virology/micro-biology NORBAC laboratory, a joint enterprise between the USA, Canada and Mexico for countering bio-terrorism.

Ingram (BA in microbiology and an MA that’s not identified in his Wikipedia entry) was a television science presenter for a number of years and has continued to work in the field of science communication. He didn’t seem all that knowledgeable about genetics when he moderated the ReGenesis panel but perhaps his focus will be about the communication element?

For anyone interested in attending the free and virtual “Breaking Through” event, you can register here.

CAR-T cell therapies (a type of somatic cell therapy)

One final note, the first week of December seems to be gene therapy week in Canada. There is another free and virtual event, the second session of the Summit for Cancer Immunotherapy: 2020 Speaker Series (Hosted by BioCanRx, Canada’s Immunotherapy Network), Note: I made a few changes to make this excerpt a bit easier to read,

Session Two: Developing better CAR T-Cell Therapies by engaging patients, performing systematic reviews and assessing real-world and economic evidence
Wednesday, December 9, 1:30 pm – 3:15pm EST [emphasis mine]
Chimeric Antigen Receptor T-cell (CAR-T) therapy is a personalized immunotherapy, currently being assessed in a Canadian Phase I/II clinical trial to test safety and feasibility for relapsed/refractory blood cancer (CD19+ Acute Lymphoblastic Leukemia and non-Hodgkin’s Lymphoma).
This virtual seminar will provide an overview of a multidisciplinary team’s collaborative efforts to synthesize evidence for the development of this clinical trial protocol, using a novel approach (the ‘Excelerator’ model). This approach involved the completion of a systematic review (objective review of existing trial data), engagement of patients and clinicians, and drawing from real world and economic evidence.
Dr. Fergusson will provide a brief introduction. Dr. Kednapa Thavorn will discuss the team’s use of economic modelling to select trial factors to maximize economic feasibility of the therapy, and Mackenzie Wilson (HQP) will discuss the current efforts and future directions to engage diverse stakeholders to inform this work. Gisell Castillo (HQP) will speak about the interviews that were conducted with patients and hematologists to identify potential barriers and enablers to participation and recruitment to the trial.
The team will also discuss two ongoing projects which build on this work. Dr. Lalu will provide an overview on the team’s patient engagement program throughout development of the trial protocol and plans to expand this program to other immunotherapy trials. Joshua Montroy (HQP) will also discuss ongoing work building on the initial systematic review, to use individual participant data meta-analysis to identify factors that may impact the efficacy of CAR-T cell therapy.
Dr. Justin Presseau will moderate the question and answer period.

And there’s this,

Who should attend?
Scientific and health care community including researchers, clinicians and HQP along with patients and caregivers. Note: There will be a plain language overview before the session begins and an opportunity to ask questions after the discussion.

If you want to know more about CAR T-cell therapy, sometimes called gene or cell therapy or immune effect cell therapy, prior to the Dec., 9, 2020 event, this page on the cancer.org website should prove helpful.

Copyright and patent protections and human rights

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The United Nations (UN) and cultural rights don’t immediately leap to mind when the subjects of copyright and patents are discussed. A Mar. 13, 2015 posting by Tim Cushing on Techdirt and an Oct. 14, 2015 posting by Glyn Moody also on Techdirt explain the connection in the person of Farida Shaheed, the UN Special Rapporteur on cultural rights and the author of two UN reports one on copyright and one on patents.

From the Mar. 13, 2015 posting by Tim Cushing,

… Farida Shaheed, has just delivered a less-than-complimentary report on copyright to the UN’s Human Rights Council. Shaheed’s report actually examines where copyright meshes with arts and science — the two areas it’s supposed to support — and finds it runs contrary to the rosy image of incentivized creation perpetuated by the MPAAs and RIAAs of the world.

Shaheed said a “widely shared concern stems from the tendency for copyright protection to be strengthened with little consideration to human rights issues.” This is illustrated by trade negotiations conducted in secrecy, and with the participation of corporate entities, she said.

She stressed the fact that one of the key points of her report is that intellectual property rights are not human rights. “This equation is false and misleading,” she said.

The last statement fires shots over the bows of “moral rights” purveyors, as well as those who view infringement as a moral issue, rather than just a legal one.

Shaheed also points out that the protections being installed around the world at the behest of incumbent industries are not necessarily reflective of creators’ desires. …

Glyn Moody’s Oct. 14, 2015 posting features Shaheed’s latest report on patents,

… As the summary to her report puts it:

There is no human right to patent protection. The right to protection of moral and material interests cannot be used to defend patent laws that inadequately respect the right to participate in cultural life, to enjoy the benefits of scientific progress and its applications, to scientific freedoms and the right to food and health and the rights of indigenous peoples and local communities.

Patents, when properly structured, may expand the options and well-being of all people by making new possibilities available. Yet, they also give patent-holders the power to deny access to others, thereby limiting or denying the public’s right of participation to science and culture. The human rights perspective demands that patents do not extend so far as to interfere with individuals’ dignity and well-being. Where patent rights and human rights are in conflict, human rights must prevail.

The report touches on many issues previously discussed here on Techdirt. For example, how pharmaceutical patents limit access to medicines by those unable to afford the high prices monopolies allow — a particularly hot topic in the light of TPP’s rules on data exclusivity for biologics. The impact of patents on seed independence is considered, and there is a warning about corporate sovereignty chapters in trade agreements, and the chilling effects they can have on the regulatory function of states and their ability to legislate in the public interest — for example, with patent laws.

I have two Canadian examples for data exclusivity and corporate sovereignty issues, both from Techdirt. There’s an Oct. 19, 2015 posting by Glyn Moody featuring a recent Health Canada move to threaten a researcher into suppressing information from human clinical trials,

… one of the final sticking points of the TPP negotiations [Trans Pacific Partnership] was the issue of data exclusivity for the class of drugs known as biologics. We’ve pointed out that the very idea of giving any monopoly on what amounts to facts is fundamentally anti-science, but that’s a rather abstract way of looking at it. A recent case in Canada makes plain what data exclusivity means in practice. As reported by CBC [Canadian Broadcasting Corporation] News, it concerns unpublished clinical trial data about a popular morning sickness drug:

Dr. Navindra Persaud has been fighting for four years to get access to thousands of pages of drug industry documents being held by Health Canada.

He finally received the material a few weeks ago, but now he’s being prevented from revealing what he has discovered.

That’s because Health Canada required him to sign a confidentiality agreement, and has threatened him with legal action if he breaks it.

The clinical trials data is so secret that he’s been told that he must destroy the documents once he’s read them, and notify Health Canada in writing that he has done so….

For those who aren’t familiar with it, the Trans Pacific Partnership is a proposed trade agreement including 12 countries (Australia, Brunei Darussalam, Canada, Chile, Japan, Malaysia, Mexico, New Zealand, Peru, Singapore, United States, and Vietnam) from the Pacific Rim. If all the countries sign on (it looks as if they will; Canada’s new Prime Minister as of Oct. 19, 2015 seems to be in favour of the agreement although he has yet to make a definitive statement), the TPP will represent a trading block that is almost double the size of the European Union.

An Oct. 8, 2015 posting by Mike Masnick provides a description of corporate sovereignty and of the Eli Lilly suit against the Canadian government.

We’ve pointed out a few times in the past that while everyone refers to the Trans Pacific Partnership (TPP) agreement as a “free trade” agreement, the reality is that there’s very little in there that’s actually about free trade. If it were truly a free trade agreement, then there would be plenty of reasons to support it. But the details show it’s not, and yet, time and time again, we see people supporting the TPP because “well, free trade is good.” …
… it’s that “harmonizing regulatory regimes” thing where the real nastiness lies, and where you quickly discover that most of the key factors in the TPP are not at all about free trade, but the opposite. It’s about as protectionist as can be. That’s mainly because of the really nasty corprorate sovereignty clauses in the agreement (which are officially called “investor state dispute settlement” or ISDS in an attempt to make it sound so boring you’ll stop paying attention). Those clauses basically allow large incumbents to force the laws of countries to change to their will. Companies who feel that some country’s regulation somehow takes away “expected profits” can convene a tribunal, and force a country to change its laws. Yes, technically a tribunal can only issue monetary sanctions against a country, but countries who wish to avoid such monetary payments will change their laws.

Remember how Eli Lilly is demanding $500 million from Canada after Canada rejected some Eli Lilly patents, noting that the new compound didn’t actually do anything new and useful? Eli Lilly claims that using such a standard to reject patents unfairly attacks its expected future profits, and thus it can demand $500 million from Canadian taxpayers. Now, imagine that on all sorts of other systems.

Cultural rights, human rights, corporate rights. It would seem that corporate rights are going to run counter to human rights, if nothing else.

Bring back the mandatory Canadian long form census: a long shot private member’s bill in Parliament

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It’s been over four years since I last mentioned the mandatory Canadian long form census, a topic which seems to be enjoying some new interest. For those unfamiliar or whose memory of the controversy is foggy, here’s a brief description of the situation. The mandatory aspect of the long form census was abolished by the Conservative government despite serious opposition from core Conservative supporters in the business community and at least two of the Prime Minister’s own cabinet members. There’s more about the discussion at the time in my July 20, 2010 posting (scroll down about 25% of the way).

Thanks to David Bruggeman’s Feb. 1, 2015 post cleverly titled, Counting The Impact Of How A Government Counts, on his Pasco Phronesis blog, I can update the situation (Note: Links have been removed).

Back in 2010, the Canadian government opted to make the long form portion of its 2011 census voluntary. Researchers who use the data in their work, and policymakers who use the data to make decisions were concerned about how a voluntary survey would impact the resulting data.

As expected, the early analysis suggests that the lower quality data will lead to higher spending. …

Ted Hsu, Liberal member of Parliament (MP), introduced Bill C-626 An Act to amend the Statistics Act (appointment of Chief Statistician and long-form census in Sept. 2014 when it received its first reading. Last week, Jan. 29, 2015, the bill received its second reading and was referred to committee according to this Bill C-626 webpage on the openparliament.ca website. I’m excerpting portions of Ted Hsu’s Jan. 29, 2015 (?) comments from the House of Commons floor, (from openparliament.ca’s Bill C-626 webpage; Note: Links have been removed),

Today I rise to present my private member’s bill, Bill C-626. It is a bill that reflects the belief that people must have trustworthy information about themselves to govern themselves wisely.

Indeed, the Prime Minister himself said in his recent speech to the United Nations:

…vital statistics are critical.

You can’t manage what you can’t measure.

We parliamentarians should aspire to safeguard the integrity and quality of fundamental information about the people of Canada, whom we endeavour to serve. Is that not what we seek when we pray at the beginning of each day in the House of Commons: Grant us wisdom, knowledge, and understanding to preserve the blessings of this country for the benefit of all, and to make good laws and wise decisions?

However, the quality of national statistics has been compromised. In 2011, the voluntary national household survey replaced the long form census. Researchers have publicly called that survey worthless.

What are some of the effects? In May 2014, the Progressive Conservative premier of New Brunswick said that the elimination of the long form census makes it hard to track the outcomes of the province’s poverty program. That is, it is hard to figure out what New Brunswick got from the money spent to help the poor.

National household survey data were too meaningless to be published for 25% of Canada’s towns and cities because of low response rates, rising to 30% in Newfoundland and Labrador’s and 40% in Saskatchewan.

All levels of government and the private sector have been handicapped by bad data here in Canada. What is worse is that the one mandatory long form census forms an essential anchor that is needed to adjust for errors in many other voluntary surveys. We have lost that data anchor.

Why is the voluntary national household survey so poor? The problem is that certain groups of people tended not to fill out the voluntary survey. Rural residents, single parents, one-person households, renters, the very rich, the poor, and younger people all tended not to complete the national household survey. The result is a biased and misleading picture of Canada and Canadians. This is what scientists call a systematic error. A systematic error, unlike a random error, cannot be corrected by sending out more census forms.

This systematic error is eliminated if everyone who receives a long form survey fills it out. Not filling out the long form census is a disservice to the country. That is why filling out the census should be considered a civic duty.

In 2011, the government went ahead and sent out more voluntary surveys to compensate for the lower response rate. This inflated the cost of the census by approximately $20 million, but it gave us poorer information. Avoiding such waste is another reason we should restore the mandatory long form census.

More importantly, making business and investment decisions and managing the economy and the affairs of the people all require trustworthy information about the people. That is why, just this past summer, the Canadian Chamber of Commerce passed a policy resolution calling for the restoration of the mandatory long form census. That is why, in 2010, groups such as the Canadian Association for Business Economics, the Canadian Federation of Independent Business, the Conference Board of Canada, and the Toronto Region Board of Trade opposed the elimination of the mandatory long form census.

Let me say this again. The Canadian Chamber of Commerce, the Canadian Association for Business Economics, the Canadian Federation of Independent Business, the Conference Board of Canada, and the Toronto Region Board of Trade want the mandatory long form census.

…

It’s well worth reading all of the comments as they run both pro and con. BTW, kudos to the openparliament.ca website for making information about legislation and the legislative process so accessible!

The Globe & Mail newspaper ran a Nov. 6, 2014 editorial about six weeks after the bill was first introduced,

Bill C-626, a private member’s bill that would restore the mandatory long-form census and shield the Chief Statistician of Canada from political interference, has no chance of becoming law. It was introduced by a Liberal MP, Ted Hsu, and has limited support in Parliament. Even more foreboding, its adoption would require the Harper government [Stephen Harper, Prime Minister, Canada] to do something it loathes: admit an error.

But an error it was – and a now well-documented one – for the government to eliminate the mandatory long-form census in 2010 and replace it with the voluntary National Household Survey.

To be fair, I don’t know of any government that admits its errors easily but, even by those standards, the Harper government seems extraordinarily loathe to do so.

More of the new National Household Survey’s shortcomings come to light in a Jan. 29, 2015 article by Tavia Grant for the Globe & Mail,

The cancellation of the mandatory long-form census has damaged research in key areas, from how immigrants are doing in the labour market to how the middle class is faring, while making it more difficult for cities to ensure taxpayer dollars are being spent wisely, planners and researchers say.

Statistics Canada developed a voluntary survey after Ottawa cancelled the long-form census in 2010. Many had warned that the switch would mean lower response rates and policies based on an eroded understanding of important trends. Now researchers – from city planners to public health units – say they have sifted through the 2011 data and found it lacking.

Their comments come as a private member’s bill to reinstate the mandatory long-form census will be debated in the House of Commons Thursday [Jan. 29, 2015]. The bill, expected to be voted on next week, has slim odds of passing, given the Conservative majority. But it is drawing attention to the impact of the switch, which has created difficulties in determining income-inequality trends, housing needs and whether low-income families are getting adequate services.

The impact isn’t just on researchers. Cities, such as Toronto, say it’s become more expensive and requires more staffing to obtain data that’s of lower quality. …

…

Sara Mayo, social planner at the Social Planning and Research Council of Hamilton [Ontario], says the result of the census changes has been less data for more money. “In terms of fiscal prudence, this made no sense. Why would any government want to pay more for worse-quality data?” [emphasis mine]

Many, many people noted in 2010 that we would be paying more for lower quality data. Adding insult to injury, the cancellation was not made due to a huge public outcry demanding the end of the mandatory long form census, In fact, as I noted earlier, many of Stephen Harper’s core supporters were not in favour of his initiative.

Moving on to Ted Hsu for a moment, I was interested to note that he will not be running for election later this year (2015) according to an Aug.7, 2014 article on thestar.com website. For now, according to his Wikipedia entry, Hsu is the the Liberal Party’s Critic for Science and Technology, Post-Secondary Education, Federal Economic Development Agency for Southern Ontario and Federal Economic Development Initiative in Northern Ontario. By training, Hsu is a physicist.

While no one seems to hold much hope for Hsu’s bill, there is a timeline provided for its passage through Parliament before the final vote (from tedshu.ca’s C-626 webpage),

First reading: September 22, 2014
First hour of second reading debate: November 7, 2014
Second hour of second reading debate: January 29, 2015
Second reading vote to send the bill to committee: February 4, 2015
Committee hearings: March-April (expected)
Report Stage to vote on any amendments and the report from committee: April 2015 (expected)
Final hour of debate and third reading vote to send the bill to the Senate: April 2015 (expected)

According to the openparliament.ca website the Jan. 29, 2015 reading was the one where the bill was sent to committee but Ted Hsu’s site suggests that today’s Feb. 4, 2015 reading is when the vote to send the bill to committee will be held.

ETA Feb. 4, 2014 1420 PDT: Apparently, city governments are weighing in the discussion, from a Feb. 3, 2015 article by Tavia Grant and Elizabeth Church for the Globe & Mail,

The debate over the demise of the mandatory long-form census has reached the city level in Canada, where mayors and local officials say the cancellation has hampered the ability to plan and support the needs of their communities.

Toronto Mayor John Tory told The Globe and Mail he plans to raise the issue at the big city mayors’ meeting this week.

…

Across the country, cities are feeling the impact of the census changes, said Brad Woodside, president of the Federation of Canadian Municipalities and mayor of Fredericton [New Brunswick].

“We’ve heard from our members that the change to the new National Household Survey [NHS] is impacting their ability to effectively plan and monitor the changing needs of their communities,” he said in an e-mailed statement to The Globe. “We support all efforts to increase the reliability of the data from the census.”

…

A website that lobbies for more accessible data, called Datalibre.ca, lists 11 individuals and organizations that supported the government’s decision to scrap the census and 488 who oppose it. Those who were against the move include 42 cities – from Red Deer to Montreal, Victoria and Fredericton.

Regina’s mayor said the loss of detailed data is a concern. He wants the long-form reinstated.

…

In Vancouver, city planner Michael Gordon said the end of the mandatory census is a “significant issue,” hampering the ability to analyze infrastructure needs, such as transportation planning, along with housing, particularly affordable housing. Mr. Gordon, president of the Canadian Institute of Planners, has found some data from NHS “fishy,” and says there has been a “very disappointing” impact in the ability to provide sound advice based on factual information.

Unfortunately, I haven’t been able to find any information as to whether today’s vote to send this bill committee was successful or not.

ETA Feb. 5, 2015 0840 PDT: The bill did not make it past the second reading, from a Feb. 4, 2015 news item (posted at 2000 hours EDT) on the Huffington Post,

Liberal MP Ted Hsu’s drive to resurrect the long-form census has come to an end.

His private member’s bill to bring back the long-form census and bolster the independence of the chief statistician was voted down on second reading in the Commons on Wednesday.

Canada’s barley crop needs a little help to adapt to climate change

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“Building better barley” is the title for a Dec. 12, 2012 news release from the University of Alberta (by Bev Betkowski) on EurekAlert. They might have wanted to add the phrase “in the face of climate change” but that ruins the alliteration. From the news release,

As one of the top 10 barley producers in the world, Canada faces a problem of adapting to the ‘new normal’ of a warmer, drier climate.

The 2012 growing season was considered an average year on the Canadian Prairies, “but we still had a summer water deficit, and it is that type of condition we are trying to work with,” said Scott Chang, a professor of soil science in the University of Alberta’s Department of Renewable Resources in Edmonton, Canada.

The Dec. 5, 2012 article (which originated the news release) by Betkowski for the Faculty of Agricultural, Life and Environmental Sciences at the University of Alberta provides more detail about the why and the how,

Chang began teaming up with fellow crop scientist Anthony Anyia of Alberta Innovates – Technology Futures in 2006, following a severe drought in 2002 that dropped average crop yield in Alberta by about half. They are exploring the genetic makeup of barley and how the grain crop—a Canadian staple used for beer malt and animal feed—can be made more efficient in its water use and more productive. One of their latest studies, published in the journal Theoretical and Applied Genetics, explores how to increase yield in barley crops while using less water.

…The latest study was led by lead author Jing Chen, a former PhD student in Chang and Anyia’s lab. The group planted and harvested two common types of barley plants in test plots around Alberta, then analyzed the plants for genetic traits and other factors such as height, days to maturity and yield.

By studying the carbon isotope compositions of barley plants and their relationship with water-use efficiency, the researchers developed tools that plant breeders can use to improve selection efficiency for more water-efficient varieties. The latest findings stem from an ongoing collaboration that is ultimately aimed at bringing farmers a more stable breed of the plant that has less reliance on water and is less vulnerable to climate change.

Coincidentally (or not), the Canadian federal government in the person of Agriculture Minister Gerry Ritz, within a week of the story and news release by Betkowski, congratulates itself for previous funding and new programs in two separate news releases.

The Harper Government Supports Canadian Barley Industry news release of Dec. 7, 2012 had this comment for the Alberta Barley Commission’s annual general meeting in Banff,

“As the one-year anniversary of the adoption of the Marketing Freedom for Grain Farmers Act approaches, western Canadian grain farmers are already enjoying the economic potential of an open market,” said Minister Ritz. “I would like to thank the Alberta Barley Commission for its long-standing leadership in support of marketing freedom, innovation and a strong future for barley producers.”

Canadian barley, known around the world for its high quality and superior characteristics, generated over $270 million in exports last year—a figure expected to continue to grow with the new marketing freedom options. The Marketing Freedom for Grain Farmers Act, which received Royal Assent on December 15, 2011, allows anyone to buy and sell wheat and barley. By unleashing the sector’s economic potential and entrepreneurial energy, the open grain market continues to usher in a new era of innovation and growth for Western Canada’s grain industry, helping attract investment, encourage innovation, create value-added jobs and build a stronger economy.

Additionally, the Harper government recently announced an AgriMarketing investment of more than $525,000 to enable the Canadian Malting Barley Technical Centre, the Malting Industry Association of Canada, and the Brewing and Malting Barley Research Institute to increase their competitiveness in new and existing markets through innovative marketing and communications and through the development of a Canadian Malt Barley Brand. [emphasis mine] Product testing and evaluations will also be done on new malting barley varieties, the current year’s harvest and cargo shipments to highlight the attributes of the current Canadian crop for international customers.

The Harper government’s long-term strategy to strengthen and modernize the barley industry includes renewing the mandate of the Crop Logistics Working Group, to improve the performance of the supply chain for barley and all crops, and to ensure that the agricultural sector can reap the rewards of a dynamic and growing global marketplace.

On the same day in Calgary, the Harper Government Announces Federal Growing Forward 2 Programs news release of Dec. 7, 2012 proclaims new programs and, presumably, there will be additional funding at some point,

Agriculture Minister Gerry Ritz today unveiled three new federal programs under Canada’s new agricultural policy framework Growing Forward 2 that will streamline investments in the agriculture and agri-food sector. The new programs will focus on strategic initiatives in innovation, competitiveness and market development to further strengthen the sector’s capacity to grow and prosper.

“These new Growing Forward 2 programs will build on the success of existing programs to provide more streamlined support to the sector to help it remain a world leader in agricultural innovation and trade,” said Minister Ritz. “We are making sure farmers and the entire sector have the tools and resources they need to stay ahead of the ever-changing demands of consumers.”

Three new federal programs will come into effect on April 1, 2013:

The AgriInnovation Program will focus on investments to expand the sector’s capacity to develop and commercialize new products and technologies.

The AgriMarketing Program will help industry improve its capacity to adopt assurance systems, such as food safety and traceability, to meet consumer and market demands. It will also support industry in maintaining and seizing new markets for their products through branding and promotional activities.

The AgriCompetitiveness Program will target investments to help strengthen the agriculture and agri-food industry’s capacity to adapt and be profitable in domestic and global markets.

Agriculture and Agri-Food Canada is proactively providing information to farmers and the industry so that they are familiar with the kind of support that will be available and so they may plan their applications well in advance. The AgriInnovation Program will begin accepting applications immediately, while AgriMarketing and AgriCompetitiveness will begin accepting applications early in the new year.

Growing Forward 2 represents a $3 billion investment over five years in strategic initiatives for innovation, competitiveness and market development, in addition to a full and comprehensive suite of business risk management programs that will continue to help farmers withstand severe market volatility and disasters. Investments in the three priority areas are critical to facilitating the sector’s expansion and leveraging of provincial-territorial and industry investments to increase productivity, growth and jobs.

Canadian Prime Minister Stephen Harper, for those who do not know, is from the province of Alberta.

This is an interesting example, whether the announcements are coincidental or not, of the relationship between research taking place in the universities, government and its programmes, and the international marketplace. For those interested in Chang’s research, here’s the citation for the paper from his webpage,

Chen, J., Chang, S.X. and Anya, A.O. 2012. Quantitative trait loci for water-use efficiency in barley (Hordeum vulgare L.) measured by carbon isotope discrimination under rain-fed conditions on the Canadian Prairies, Theoretical and Applied Genetics 125: 71–90.

Springer, publisher for the journal Theoretical and Applied Genetics, is offering a free preview during the month of December 2012 so you can view the article or any other one in the journal ’til Dec. 31, 2012.

Attracting creatives and economic opportunities

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The Canadian 2012 federal budget was presented today (Mar.29.12) and so a discussion about creativity and economic opportunities seems à propos. I’ll start with Amsterdam (Holland/The Netherlands) and THNK. Neal Ungerleider, in his March 27, 2012 article titled, The THNK Tank: Why Amsterdam Wants Your (Creative) Brains, for Fast Company notes,

Amsterdam is embarking on an ambitious experiment to attract foreign creatives: An invite-only, public/private-funded school and accelerator for international creative minds, leaders, and entrepreneurs. THNK: The Amsterdam School of Creative Leadership opened several weeks ago with an initial class of 30 drawn from across Europe, the United States, China, India, Israel, Mauritius, and South Africa. Classes and mentoring at THNK are held both in Amsterdam–in a home base inside a converted gasworks–and via telecommuting once participants return to their home countries.

…

For Amsterdam, THNK is a slick business development project that simultaneously doubles as soft diplomacy. The thinkers and doers who will be joining in THNK’s activities will be connected with local entrepreneurs, artists, and firms–whom the city is doubtlessly hoping will be back in the future.

The partnership behind this initiative includes the Dutch federal government, the province of Noord-Holland, Stadsregio Amsterdam (a regional conglomeration of 16 municipalities in what is dubbed as the ‘Amsterdam region’, The Netherlands Chamber of Commerce, and I amsterdam.

These organizations certainly seem to be modeling leadership. Here’s more about their initiative, from the About THNK page,

Of course the world is changing. That’s what it’s done since time began. Evolution is natural. Sometimes it happens slowly. And sometimes it rocks the world like a fiery volcano, suddenly transforming entire landscapes.

Our world has reached that point now. Social inequality, our love/hate relationship with technology, dwindling resources, climate change, the collapse of financial institutions…

Organizations of all types, shapes and sizes are struggling with this new reality. Some are so involved in daily operations – and keeping their heads above water – they are blind to the future. Others recognize the challenges around them, but lack vision.

THNK believes the answer is passionate, visionary and creative leadership.

Creative leadership according to THNK means: public, social and business worlds coming together to create and realize new and innovative solutions to major issues of societal relevance that will have great meaning and impact – either nationally or internationally.

This isn’t just about generating ideas. It’s also about making it happen.

About Amsterdam

…

Although our focus is international, THNK is firmly rooted in Amsterdam. We’ve made the Westergasfabriek our home. This 19th-century former gas factory has been transformed into one of the city’s most exciting cultural centers, with old industrial buildings now housing trendsetting cafes, cinema, festivals and other events. Not to mention the surrounding city parks – with everything from hidden waterways to bike paths reaching from the countryside to the heart of Amsterdam.

Thanks to its highly diverse culture – with more than 175 nationalities – and an inventive and tolerant mentality, Amsterdam has grown into an important international hub for creative thought and industry. The city’s unique DNA of creativity, tolerance, diversity, collaboration and trade is reflected in THNK’s highly pragmatic and open culture.

It’s not surprising that such diverse influences have brought forth such creativity. Three of our local scientists have been awarded Nobel prizes. Fashion designers Viktor & Rolf have wowed the world. Droog designer Marcel Wanders has changed the way we look at interior design. Architects such as Ben van Berkel are reshaping our skylines.

Amsterdam’s unique DNA of creativity, tolerance, diversity, collaboration and trade will be reflected in THNK’s highly pragmatic and open culture. Reaching beyond its borders, Amsterdam serves as a major gateway into continental Europe. With two major seaports within a 50-kilometer radius, strong international railroad connections and Amsterdam Airport Schiphol close by, you’re always close to anywhere in Europe and the world.

They do invite applications (perhaps the invite-only applications were a feature for the first cohort). You can get more information here or go here to apply immediately. The 18-month program costs € 39,500 (approx. $52, 520 CAD) and there are periods when you are required to be in Amsterdam, so you may want to include some housing and travel costs as well.

Meanwhile in Vancouver (Canada), Simon Fraser University (SFU) is about to host BCreative 2012 from May 10 – 12, 2012. From the BCreactive 2012 conference/showcase About page,

… designed to bring together government, business, the creative sector, and researchers to stimulate thinking, policy, and action directed at developing a strategy and levering resources to further build the creative economy and to help British Columbia BC become a leader in the creative sector in the twenty-first century.

BCreative 2012 conference/showcase has four specific objectives:

To make the case for the creative economy to have a commanding presence in government economic and cultural policy;

To build bridges between the general business community and this new and dynamic business sector with distinctive infrastructure needs from which all British Columbians can benefit both socially and economically;

To encourage information sharing among the creative sub-sectors and to sensitize the creative sector to the contribution of the creative economy to job creation and overall economic growth;

To bring forward useful information, analysis, training, and research resources that can assist in building BC’s creative economy.

Speakers include the co-author of the two UN Creative Economy reports, Edna dos Santos-Duisenberg, creative cities theorist Charles Landry, Canada Council CEO Robert Sirman, representatives from creative cities: Berlin and Paris. Partners with Simon Fraser University in this enterprise include the BC Business Council and the Vancouver Board of Trade, with Tourism Vancouver helping behind the scenes.

There’s an early bird registration fee until March 31, 2012. You can find a copy of the schedule (presumably a draft) here. I hope the participants will develop ideas as fresh and innovative as THNK.

BTW, I notice that Amsterdam’s THNK mentions scientists while the BCreative conference does not whether that omission reflects organizational difficulties or a blindspot is a mystery.

Scientists as thieves

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The movies tend to portray scientists as naïve fools/hapless pawns or villains. There is a little bit of truth in these portrayals, at least for the villains, as Sarah Rose’s new book about Robert Fortune, For All the Tea in China, makes clear.

Previewed in an article by Jenara Nerenberg on Fast Company, the book lays out the means by which the British government got its hands on the tea plant and secret to producing to tea. From the article,

Sarah Rose is the author of For All the Tea in China, which tells the true story of how tea and industrial espionage fueled the great expansion of the British Empire and the East India Company in the 1800s. The book focuses on one central character, Robert Fortune, who was a scientist sent by the British government to literally steal the secret of tea production from China, plant the Chinese tea in Darjeeling, and thus make the British Empire less reliant on trade with the Chinese and more self-sufficient by harvesting its own tea in colonial India.

Rose, in response to a question about contemporary as opposed to 19th century industrial espionage had this to say (from the article),

The vast majority the microchips for computers in America are manufactured in China–including those for the U.S. military. This creates a ridiculously high risk of espionage. Those circuits are just too small for us to know how really bad it might be, but from what I understand from the defense and trade communities, it’s a top worry. Meanwhile, the US’s relationship with China is thoroughly interdependent, as was Britain’s in the 19th Century. China owns a lot of our debt, so it loans us the money to buy the stuff China needs to export as it manufactures its way out of the poverty cycle. The two countries don’t necessarily like each other, but they need each other. When each player is so suspicious, it multiplies the competitive advantages of espionage and secrecy.

Most of the article is about tea and Robert Fortune who apparently dressed up as a Chinese Mandarin and fought off pirates in his pursuit of the plant. The focus for the book is on an adventure story and I haven’t seen any mention yet of the ramifications this theft might have had on China’s (nor for that matter India’s) economy and subsequent history.

The Wikipedia essay on Robert Fortune offers a far less colourful story,

Robert Fortune (16 September 1812 – 13 April 1880) was a Scottish botanist and traveller best known for introducing tea plants from China to India.

While the essay goes on to mention his exploits and makes it clear that he obtained the tea plants illegally, it stops short of accusing the British government and Fortune of theft and industrial espionage.

If you’re interested in Rose’s book, there’s a video trailer where she describes the story,

There’s more at Rose’s website.

This all reminds me of a course about technology transfer taught by Pat Howard (Simon Fraser University, Vancouver, Canada). We spent a fair amount of time talking about agriculture and seeds which surprised me mightily as I expected to be talking about computers and stuff.

Amongst other tasty tidbits, Pat mentioned that the Dutch burned out islands they didn’t own so they could destroy specific species of plants and retain control of the trade in spices that grew in their own territories.

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Category Archives: economics

Gene therapy in Canada; a November 2020 report and two events in December 2020

Dec. 2 – 3, 2020 Breaking Through

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Money issues

Gene therapies and gene editing

CAR-T cell therapies (a type of somatic cell therapy)

Copyright and patent protections and human rights

Bring back the mandatory Canadian long form census: a long shot private member’s bill in Parliament

Canada’s barley crop needs a little help to adapt to climate change

Attracting creatives and economic opportunities

Scientists as thieves