Monthly Archives: February 2023

Brain stimulation combined with a nose spray containing nanoparticles can improve stroke recovery (in an animal model)

A September 28, 2022 news item on Nanowerk announces research into combining nasal sprays and brain stimulation in efforts to improve stroke recovery (Note: A link has been removed),

In a recent study (Materials Today Chemistry, “Enhancing non-invasive brain stimulation with non-invasively delivered nanoparticles for improving stroke recovery”), researchers from Xi’an Jiaotong-Liverpool University and other universities in China have reported that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke in an animal model.

The nasal spray is a non-invasive method for delivering magnetic nanoparticles into the brain that the study finds can increase the benefits of transcranial magnetic stimulation (TMS). TMS is a method of non-invasive brain stimulation already used clinically or in clinical trials to treat neurological conditions like stroke, Parkinson’s disease, Alzheimer’s disease, depression, and addiction.

I have two previous posts about nasal sprays and nanoparticles (links to previous posts follow at the end) but this item is the first to include brain stimulation. From a September 27, 2022 Xi’an Jiaotong-Liverpool University press release (also on EurekAlert but published on September 28, 2022), which originated the news item,

Rats that were given combined nanoparticle and TMS treatment every 24 hours for 14 days after an ischemic stroke had better overall health, put on weight more quickly and had improved cognitive and motor functions compared to those treated with TMS alone.

During TMS treatment, an electrical current runs through an electric coil placed outside the skull, producing a magnetic field that stimulates brain cells by inducing a further electrical current inside the brain. However, the stimulation is often not intense enough to penetrate far enough into the brain to reach the areas needing treatment. 

In this new study, the researchers show that magnetic nanoparticles, administered intranasally, can make neurons more responsive and amplify the magnetic signal from TMS to reach deeper brain tissue, aiding recovery. The finding offers new opportunities for treating neurological disorders. 

From impossible to possible

The research answers a key question in nanomedicine – whether it is possible to enhance TMS by using nanoparticles that are non-invasively delivered into the brain. Leading figures in the field previously stated that it was almost impossible because of the blood-brain barrier. This physical barrier separates the brain from the rest of the body’s bloodstream.

However, the team of researchers overcame this by guiding the magnetic nanoparticles closer to the correct area with a large magnet near the head. 

Dr Gang Ruan, a corresponding author of the study, says: “We were able to overcome the blood-brain barrier and send enough nanoparticles into the brain to use in combination with TMS simulation to improve recovery from stroke. 

“TMS devices are already used for the clinical treatment of neurological disorders but have severe limitations in terms of stimulation strength and depths of the brain they can penetrate. 

“By non-invasively putting magnetic nanoparticles into the brain, we can amplify and enhance the TMS stimulation effects on neurons, making the treatment more effective,” Dr Ruan adds.

“Showing it is possible to use nanoparticles in this way paves the way for medical applications of nanoparticles for other neurological disorders.”

Crossing barriers 

The iron oxide nanoparticles used in the study are already prescribed to treat iron deficiency as they are non-toxic and biodegradable. The team also modified the nanoparticles by coating them with various non-toxic substances. 

Dr Ruan says: “The coating causes the nanoparticles to stick to the blood-brain barrier, increasing their chances of passing through it. Without this coating, the particles just bounce back from the barrier instead of crossing it.

“The modifications of the iron oxide particles also ensure that the nanoparticles can stick to the neurons and increase their responsiveness to TMS stimulation.”

The safety of using the modified nanoparticles needs to be assessed in clinical trials but has the potential to be used in combination with TMS, and other methods such as brain imaging, to gain more insight into how the brain works and improve the treatment of neurological disorders. 

“Many scientists still think it is impossible to non-invasively send enough nanoparticles into the brain to affect brain function. Yet we have shown that it is possible,” says Dr Ruan.

“We combined the expertise on our team in four different disciplines, materials science, biophysics, neuroscience, and medical science, to push the boundaries of our knowledge and challenge what is currently thought in the field.”

Here’s a link to and a citation for the paper,

Enhancing non-invasive brain stimulation with non-invasively delivered nanoparticles for improving stroke recovery by Y. Hong, J. Wang, J. Li, Z. Xu, X. Yang, M. Bai, P. Gong, Y. Xi, X. Zhang, P. Xu, X. Chen, R. Li, X. Liu, G. Ruan, G. Xua. Materials Today Chemistry Volume 26, December 2022, 101104 DOI: https://doi.org/10.1016/j.mtchem.2022.101104 First available online: 19 August 2022

This paper is behind a paywall.

As promised, here are the links to the other posts about nasal sprays and nanoparticles:

One final note, “Xi’an Jiaotong-Liverpool University (XJTLU) is an international university formed in partnership between the University of Liverpool and Xi’an Jiaotong University in China. Find out more about XJTLU

Nano4EARTH workshop recordings available online

Announced in October 2022, the US government’s Nano4EARTH is the Biden-Harris {President Joe Biden and Vice President Kamala Harris] Administration’s first national nanotechnology challenge. (You can find out more about the challenge in my November 28, 2022 posting.)

More recently, JD Supra’s February 22, 2023 news item notes Nano4EARTH’s kick-off workshop (Note: Links have been removed),

The kickoff workshop for Nano4EARTH was held January 24-25, 2023. Nano4EARTH will leverage recent investments in understanding and controlling matter at the nanoscale to develop technologies, industries, and training opportunities that address climate change. On January 26, 2023, the White House Office of Science and Technology Policy (OSTP) issued a press release summarizing the workshop. According to OSTP, more than 400 people across sectors, with diverse expertise and perspectives, participated in the workshop. OSTP states that discussions focused on identifying nanotechnologies that will have an impact on climate change in four years or less, in addition to sharing resources to address barriers to entrepreneurship and technology adoption. Workshop participants identified goals and metrics to maintain momentum throughout the challenge. New connections and networks spanning federal agencies, non-federal organizations, and industry were created and several examples of collaborations and events centered on nanotechnology and climate change developed organically between participants.

A January 26, 2023 White House Office of Science and Technology Policy (OSTP) press release, which originated the news item on JD Supra, described some common workshop themes,

  • Battery technology has seen increased adoption in personal vehicles and long-term energy storage solutions, but further advances in Li-ion, as well as new chemistries and architectures, show tremendous and broad potential. It is critical that research directions are well matched with particular use cases.
  • Catalysts leveraging new understandings of nanoscale materials and phenomena could optimize many high-greenhouse gas emitting industrial processes, minimize the need for rare-earth metals, and serve as a precursor for alternative energy sources such as green hydrogen and electrofuels. 
  • Coatings and other material innovations are likely to increase the overall efficiency of nearly any industrial process and lead to more resilient structures and devices, especially in changing and harsh environments. Examples include reflective coatings, corrosion protection, heat management in computing, lubricants and other additives, and membranes for separations. Drop-in solutions would have a more near-term impact.
  • Capture of greenhouse gasses through advanced materials and sorbents (e.g., metal organic frameworks) and nature mimicking processes (e.g., artificial photosynthesis), especially deployed at the point of production, could be impactful but deploying at scale has significant challenges. In the near term, renewable energy production and efficient transmission is worthy of increased attention.

In the months to come, the NNCO will convene a series of roundtable discussions that focus on some of the highest potential nanotechnologies identified at the kick-off workshop. Subject matter experts and federal partners will be asked to match nanotechnology opportunities to urgent climate change needs, with strong consideration of the broader societal needs and impacts. Feedback from the kick-off workshop will also inform additional activities and events to facilitate conversations and collaborations across this growing community.

The US National Nanotechnology Initiative-hosted Nano4EARTH Kick-off Workshop page features the meeting agenda where there are links to video recordings of each session.

After pretending to be Marie Curie girls stick with science

Researchers have found that pretending to be Marie Curie in a science game can lead to greater persistence when playing. From a September 27, 2022 Duke University news release (also on EurekAlert but published on September 29, 2022) by Dan Vahaba,

Fake it ‘til you make is true for children too, it turns out: Young girls embracing the role of a successful female scientist, like Marie Curie, persist longer at a challenging science game.

A new study, appearing Sept. 28 [2022] in the journal Psychological Science, suggests that science role-playing may help tighten the gender gap in science, technology, engineering, and math (STEM) education and careers for women simply by improving their identity as scientists.

Frustrated by the gender gap in STEM, in which some fields employ at least three times more men than women, Cornell graduate student Reut Shachnai wanted to do something about it. Shachnai, who is now continuing her studies at Yale, said the idea to help foster young girls’ interest in science came to her during a lecture in a class she was taking on “Psychology of Imagination.”

“We read a paper on how children pretending to be a superhero did better at self-control tasks (the so-called ‘Batman effect’),” said Tamar Kushnir, Ph.D., who taught the class and is now a Duke professor of psychology & neuroscience as well as a fellow author on the new paper. “Reut wondered if this would also work to encourage girls to persist in science.”

Along with Lin Bian, Ph.D., an assistant professor of psychology at the University of Chicago, Shachnai and Kushnir devised an experiment to test if assuming the role of a successful scientist would improve girls’ persistence in a “sink or float” science game.

The game itself was simple yet challenging: a computer screen projected a slide with an object in the center hovering above a pool of water. Kids then had to predict whether that object — be it an anchor, basketball, balloon, or others — would sink or float. After making their choice, they learned if they made the right choice as they watched the object either plunge or stay afloat.

The researchers recruited 240 four- to seven-year-olds for the experiment, because this is around the time kids first develop their sense of identity and capabilities.

“Children as early as age 6 start to think boys are smarter and better at science than girls,” said Bian, whose previous work identified this critical period.

Boys and girls were assigned to three different groups: the baseline group were told they would be scientists for the day and then got to play the game.

Children in the “story” group received the same information, but also learned about the successes and struggles of a gender-matched scientist before playing the game. Boys heard about Isaac Newton, and girls were told about Marie Curie. They also had to take a two-question pop quiz after the story to make sure they were paying attention (they were).

Finally, children in the “pretend” group did all the same things as the “story” group, with one important twist: these children were told to assume the identity of the scientist they just learned about, and were referred to as such during the game (“What’s your prediction, Dr. Marie?”).

All kids played at least one round of the game, after which they were asked if they wanted to play more or do something else. Once the kids tapped out, they were asked to rate how good they thought they were at the game and as a scientist.

No matter what group they were in, girls got the answers right just as often as boys — nearly 70% of the time. Boys, however didn’t really benefit from the stories or make-believe.

“Boys were kind of maxed out,” Kushnir said. “They were about at ceiling performance no matter what we did.”

Girls, on the other hand, benefited immensely from playing pretend.

Without being exposed to Marie Curie, girls called it quits after six trials. However, girls pretending to be Dr. Marie persisted twice as long at the sink-or-float game, playing just as much as the boys did (about 12 trials on average).

While there wasn’t much benefit to just hearing a story about Marie Curie for extending game play, it did boost girls’ ratings of themselves as science gamers.

Kushnir and her colleagues’ work poses many new questions for researchers, such as if children assuming the role of successful scientists matched by race and ethnicity might also benefit (the participants were mostly white in this study).

“Our findings suggest that we may want to take representation one step further,” Shachnai said. “Rather than merely hearing about role models, children may benefit from actively performing the type of actions they see role models perform. In other words, taking a few steps in the role model’s shoes, instead of merely observing her walk.”

A screen grab from the game,

Caption: Participants played a sink-or-float game on the computer during the study.. Credit:: Reut Shachnai, Tamar Kushnir, and Lin Bian https://osf.io/qfjk9

Here’s a link to and a citation for the paper,

Walking In Her Shoes: Pretending To Be a Female Role Model Increases Young Girls’ Persistence in Science by Shachnai, Reut, Kushnir, Tamar, Bian, Lin. Psychological Science DOI: 10.1177/09567976221119393 First published online: Sept. 28, 2022

This paper is behind a paywall.

Neuromorphic (brainlike) computing and your car (a Mercedes Benz Vision AVTR concept car)

If you’ve ever fantasized about a batmobile of your own, the dream could come true soon,

Mercedes Berz VISION AVTR [downloaded from https://www.mercedes-benz.com/en/innovation/concept-cars/vision-avtr/]

It was the mention of neuromorphic computing in a television ad sometime in September 2022 that sent me on a mission to find out what Mercedes Benz means when they use neuromorphic computing to describe a feature found in their Vision AVTR concept car. First, a little bit about the car (from the Vision AVTR webpage accessed in October 2022),

VISION AVTR – inspired by AVATAR.

The name of the groundbreaking concept vehicle stands not only for the close collaboration in developing the show car together with the AVATAR team but also for ADVANCED VEHICLE TRANSFORMATION. This concept vehicle embodies the vision of Mercedes-Benz designers, engineers and trend researchers for mobility in the distant future.

,,,

Organic battery technology.

The VISION AVTR was designed in line with its innovative electric drive. This is based on a particularly powerful and compact high-voltage battery. For the first time, the revolutionary battery technology is based on graphene-based [emphasis mine] organic cell chemistry and thus completely eliminates rare, toxic and expensive earths such as metals. Electromobility thus becomes independent of fossil resources. An absolute revolution is also the recyclability by composting, which is 100% recyclable due to the materiality. As a result, Mercedes-Benz underlines the high relevance of a future circular economy in the raw materials sector.

Masterpiece of efficiency.

At Mercedes-Benz, the consideration of efficiency goes far beyond the drive concept, because with increasing digitalisation, the performance of the large number of so-called secondary consumers also comes into focus – along with their efficient energy supply, without negatively affecting the drive power of the vehicle itself. Energy consumption per computing operation is already a key target in the development of new computer chips. This trend will continue in the coming years with the growth of sensors and artificial intelligence in the automotive industry. The neuro-inspired approach of the VISION AVTR, including so-called neuromorphic hardware, promises to minimise the energy requirements of sensors, chips and other components to a few watts. [emphasis mine] Their energy supply is provided by the cached current of the integrated solar plates on the back of the VISION AVTR. The 33 multi-directionally movable surface elements act as “bionic flaps”.

Interior and exterior merge.

For the first time, Mercedes-Benz has worked with a completely new design approach in the design of the VISION AVTR. The holistic concept combines the design disciplines interior, exterior and UX [user experience] from the first sketch. Man and human perception are the starting point of a design process from the inside out. The design process begins with the experience of the passengers and consciously focuses on the perception and needs of the passengers. The goal was to create a car that prolongs the perception of its passengers. It was also a matter of creating an immersive experience space in which passengers connect with each other, with the vehicle and the surrounding area [emphasis mine ] in a unique way.

Intuitive control.

The VISION AVTR already responds to the approach of the passengers by visualising the energy and information flow of the environment with digital neurons that flow through the grille through the wheels to the rear area. The first interaction in the interior between man and vehicle happens completely intuitively via the control unit: by placing the hand on the centre console, the interior comes to life and the vehicle recognises the driver by his breathing. This is made visible on the instrument panel and on the user’s hand. The VISION AVTR thus establishes a biometric connection with the driver [emphasis mine] and increases his awareness of the environment. The digital neurons flow from the interior into the exterior and visualise the flow of energy and information. For example, when driving, the neurons flow over the outside of the vehicle. [emphasis mine] When changing direction, the energy flows to the corresponding side of the vehicle.

The vehicle as an immersive experience space.

The visual connection between passengers and the outside world is created by the curved display module, which replaces a conventional dashboard. The outside world around the vehicle and the surrounding area is shown in real-time 3D graphics and at the same time shows what is happening on the road in front of the vehicle. Combined with energy lines, these detailed real-time images bring the interior to life and allow passengers to discover and interact with the environment in a natural way with different views of the outside world. Three wonders of nature – the Huangshan Mountains of China, the 115-metre-high Hyperion Tree found in the United States and the pink salt Lake Hillier from Australia – can be explored in detail. Passengers become aware of various forces of nature that are not normally visible to the human eye, such as magnetic fields, bioenergy or ultraviolet light.

The curved display module in the Mercedes-Benz VISION AVTR – inspired by AVATAR
[downloaded from https://www.mercedes-benz.com/en/innovation/concept-cars/vision-avtr/]

Bionic formal language.

When the boundaries between vehicle and living beings are lifted, Mercedes-Benz combines luxury and sustainability and works to make the vehicles as resource-saving as possible. With the VISION AVTR, the brand is now showing how a vehicle can blend harmoniously into its environment and communicate with it. In the ecosystem of the future, the ultimate luxury is the fusion of human and nature with the help of technology. The VISION AVTR is thus an example of sustainable luxury in the field of design. As soon as you get in, the car becomes an extension of your own body and a tool to discover the environment much as in the film humans can use avatars to extend and expand their abilities.

A few thoughts

The movie, Avatar, was released in 2009 and recently rereleased in movie houses in anticipation of the sequel, Avatar: The Way of Water to be released in December 2022 (Avatar [2009 film] Wikipedia entry). The timing, Avatar and AVTR, is interesting, oui?

Moving onto ‘organic’, which means carbon-based in this instance and, specifically, graphene. Commercialization of graphene is likely top-of-mind for the folks (European Commission) who bet 1B Euros in 2013 with European Union money to fund the Graphene Flagship project. This battery from German company Mercedes Benz must be exciting news for the funders and for people who want to lessen dependency on rare earths. Your battery can be composted safely (according to the advertising).

The other piece of good news, is the neuromorphic computing,

“The neuro-inspired approach of the VISION AVTR, including so-called neuromorphic hardware, promises to minimise the energy requirements of sensors, chips and other components to a few watts.”

On the other hand and keeping in mind the image above (a hand with what looks like an embedded object), it seems a little disconcerting to merge with one’s car, “… passengers connect with each other, with the vehicle and the surrounding area …” which becomes even more disconcerting when this appears in the advertising,

… VISION AVTR thus establishes a biometric connection with the driver … The digital neurons flow from the interior into the exterior and visualise the flow of energy and information. For example, when driving, the neurons flow over the outside of the vehicle.

Are these ‘digital neurons’ flowing around the car like a water current? Also, the car is visualizing? Hmm …

I did manage to find a bit more information about neuromorphic computing although it’s for a different Mercedes Benz concept car (there’s no mention of flowing digital neurons) in a January 18, 2022 article by Sally Ward-Foxton for EE Times (Note: A link has been removed),

The Mercedes Vision EQXX concept car, promoted as “the most efficient Mercedes-Benz ever built,” incorporates neuromorphic computing to help reduce power consumption and extend vehicle range. To that end, BrainChip’s Akida neuromorphic chip enables in-cabin keyword spotting as a more power-efficient way than existing AI-based keyword detection systems.

“Working with California-based artificial intelligence experts BrainChip, Mercedes-Benz engineers developed systems based on BrainChip’s Akida hardware and software,” Mercedes noted in a statement describing the Vision EQXX. “The example in the Vision EQXX is the “Hey Mercedes” hot-word detection. Structured along neuromorphic principles, it is five to ten times more efficient than conventional voice control,” the carmaker claimed.

That represents validation of BrainChip’s technology by one of its early-access customers. BrainChip’s Akida chip accelerates spiking neural networks (SNNs) and convolutional neural networks (via conversion to SNNs). It is not limited to a particular application, and also run [sic] person detection, voice or face recognition SNNs, for example, that Mercedes could also explore.

This January 6, 2022 article by Nitin Dahad for embedded.com describes what were then the latest software innovations in the automotive industry and segues into a description of spiking neural networks (Note: A link has been removed),

The electric vehicle (EV) has clearly become a key topic of discussion, with EV range probably the thing most consumers are probably worried about. To address the range concern, two stories emerged this week – one was Mercedes-Benz’ achieving a 1,000 km range with its VISION EQXX prototype, albeit as a concept car, and General Motors announcing during a CES [Consumer Electronics Show] 2022 keynote its new Chevrolet Silverado EV with 400-mile (640 km) range.

In briefings with companies, I often hear them talk about the software-defined car and the extensive use of software simulation (or we could also call it a digital twin). In the case of both the VISION EQXX and the Silverado EV, software plays a key part. I also spoke to BlackBerry about its IVY platform and how it is laying the groundwork for software-defined vehicles.

Neuromorphic computing for infotainment

This efficiency is not just being applied to enhancing range though. Mercedes-Benz also points out that its infotainment system uses neuromorphic computing to enable the car to take to “take its cue from the way nature thinks”.

Mercedes-Benz VISION EQXXMercedes-Benz VISION EQXX

The hardware runs spiking neural networks, in which data is coded in discrete spikes and energy only consumed when a spike occurs, reducing energy consumption by orders of magnitude. In order to deliver this, the carmaker worked with BrainChip, developing the systems based on its Akida processor. In the VISION EQXX, this technology enables the “Hey Mercedes” hot-word detection five to ten times more efficiently than conventional voice control. Mercedes-Benz said although neuromorphic computing is still in its infancy, systems like these will be available on the market in just a few years. When applied on scale throughout a vehicle, they have the potential to radically reduce the energy needed to run the latest AI technologies.

For anyone curious about BrainChip, you can find out more here.

It took a little longer than I hoped but I’m glad that I found out a little more about neuromorphic computing and one application in the automotive industry.

Public can now vote for 2023 Morgridge (Institute for Research) Ethics Cartooning Competition

A February 21, 2023 Morgridge Institute for Research news release on EurekAlert announced open voting in their ethics cartooning competition,

Eighteen cartoons have been selected as finalists in the 2023 Ethics Cartooning Competition, an annual contest sponsored by the Morgridge Institute for Research. 

Participants from the University of Wisconsin-Madison and affiliated biomedical centers or institutes submitted their work, then a panel of judges selected the final cartoons for display to the public, who is invited to vote and help determine the 2023 winners.

This year’s cartoons depict a variety of research ethics topics, such as the ethics of scientific publishing, research funding and environments, questionable research practices, drug pricing, the ethics of experimenting on animals, social impacts of scientific research, and scientists as responsible members of society.

The Morgridge Ethics Cartooning Competition, developed by Morgridge Bioethics Scholar in Residence Pilar Ossorio, encourages scientists to shed light on timely or recurring issues that arise in scientific research.

“Ethical issues are all around us,” says Ossorio. “An event like the competition encourages people to identify some of those issues, perhaps talk about them with friends and colleagues, and think about how to communicate about those issues with a broader community of people.”

Public voting is open until March 10, 2023: https://morgridge.org/story/ethics-cartooning-contest-vote-2023/

Some of the cartoons feature biting commentary,

https://morgridge.org/wp-content/uploads/2023-R.png

The one above hit home as I commented on a local (Vancouver, Canada) billionaire’s (Chip Wilson of Lululemon) announcement that he was spending $100M on research to treat a rare disease (facio-scapulo-humeral muscular dystrophy [FSHD]) he has. (See my April 5, 2022 posting, scroll down about 80% of the way to the subhead, Money makes the world go around.)

And this too caught my eye,

https://morgridge.org/wp-content/uploads/2023-G.png

It reminds me that I’ve been meaning to do a piece on science and racism for the last few years. Maybe this year, eh?

In the meantime, go vote, there’s another 16 to choose from and you have until March 10, 2023: https://morgridge.org/story/ethics-cartooning-contest-vote-2023/

3D print healthy chocolates

I’m a little late for Valentine’s Day, February 14, 2023, but it’s not too late for chocolate.

A February 14, 2023 news item on ScienceDaily describes research into 3D printing ‘healthy’ chocolates,

A Rutgers [Rutgers State University of New Jersey, US] scientist has developed a formulation of low-fat chocolate that can be printed on a 3D printer in pretty much any shape a person can conceive, including a heart.

A February 13, 2023 Rutgers University news release (also on EurekAlert but published February 14, 2023) by Kitta MacPherson, which originated the news item, describes research into ‘functional foods’,

The work heralds what the researcher hopes will be a new line of “functional foods” – edibles specially designed with health benefits. The aim is to develop healthier kinds of chocolate easily accessible to consumers.

Reporting in the scientific journal, Food Hydrocolloids, a Rutgers-led team of scientists described the successful creation and printing of a mixture producing low-fat chocolate — substituting fatty cocoa butter with a lower-fat, water-in-oil emulsion.

“Everybody likes to eat chocolate, but we are also concerned with our health,” said Qingrong Huang, a professor in the Department of Food Science at the Rutgers School of Environmental and Biological Sciences. “To address this, we have created a chocolate that is not only low-fat, but that can also be printed with a 3D printer. It’s our first ‘functional’ chocolate.”

Huang, an author of the study, said he already is working on manipulating sugar content in the new chocolate formulation for low-sugar and sugar-free varieties.

Researchers create emulsions by breaking down two immiscible liquids into minute droplets. In emulsions, the two liquids will usually quickly separate – as is the case with oil and vinegar – unless they are held together by a third, stabilizing ingredient known as an emulsifier. (An egg is the emulsifier in a vinaigrette.)

Chocolate candy is generally made with cocoa butter, cocoa powder and powdered sugar and combined with any one of a variety of different emulsifiers.

For the study, the scientific team experimented with different ratios of the ingredients for a standard chocolate recipe to find the best balance between liquid and solid for 3D printing. Seeking to lower the level of fat in the mixture, researchers created a water-in-cocoa butter emulsion held together by gum arabic, an extract from the acacia tree that is commonly used in the food industry, to replace the cocoa butter. The researchers mixed the emulsion with golden syrup to enhance the flavor and added that combination to the other ingredients.

As delightful as it is to eat, Huang said, chocolate is a material rich with aspects for food scientists to explore.

Employing advanced techniques examining the molecular structure and physical properties of chocolate, researchers investigated the printed chocolate’s physical characteristics. They were seeking the proper level of viscosity for printing and looking for the optimal texture and smoothness “for a good mouthfeel,” Huang said. Experimenting with many different water-oil ratios, they varied the percentages of all the main ingredients before settling on one mixture.

In 3D printing, a printer is used to create a physical object from a digital model by laying down layers of material in quick succession. The 3D printer, and the shapes it produces, can be programmed by an app on a cellphone, Huang said.

Ultimately, Huang said he plans to design functional foods containing healthy added ingredients – substances he has spent more than two decades studying, such as extracts from orange peel, tea, red pepper, onion, Rosemary, turmeric, blueberry and ginger – that consumers can print and eat.

“3D food printing technology enables the development of customized edible products with tailored taste, shape and texture as well as optimal nutrition based on consumer needs,” Huang said.

Other researchers on the study included Siqi You and Xuanxuan Lu of the Department of Food Science and Engineering at Jinan University in Guangzhou, China.

Here’s a link to and a citation for the paper,

Development of fat-reduced 3D printed chocolate by substituting cocoa butter with water-in-oil emulsions by Siqi You, Qingrong Huang, and Xuanxuan Lu. Food Hydrocolloids Volume 135, February 2023, 108114 DOI: https://doi.org/10.1016/j.foodhyd.2022.108114

This paper is behind a paywall.

Water-based ionic computing (neural computing networks)

An ionic circuit comprising hundreds of ionic transistors
Caption: An ionic circuit comprising hundreds of ionic transistors. Credit: Woo-Bin Jung/Harvard SEAS

I love that image and it pertains to this September 29, 2022 news item on ScienceDaily,

Microprocessors in smartphones, computers, and data centers process information by manipulating electrons through solid semiconductors but our brains have a different system. They rely on the manipulation of ions in liquid to process information.

Inspired by the brain, researchers have long been seeking to develop ‘ionics’ in an aqueous solution. While ions in water move slower than electrons in semiconductors, scientists think the diversity of ionic species with different physical and chemical properties could be harnessed for richer and more diverse information processing.

Ionic computing, however, is still in its early days. To date, labs have only developed individual ionic devices such as ionic diodes and transistors, but no one has put many such devices together into a more complex circuit for computing — until now.

A team of researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), in collaboration with DNA Script, a biotech startup, have developed an ionic circuit comprising hundreds of ionic transistors and performed a core process of neural net computing.

A September 28, 2022 Harvard John A. Paulson School of Engineering and Applied Sciences news release (also on EurekAlert but published on Sept. 29, 2022), which originated the news item, provides details (Note: A link has been removed),

The researchers began by building a new type of ionic transistor from a  technique they recently pioneered. The transistor consists of an aqueous solution of quinone molecules, interfaced with two concentric ring electrodes with a center disk electrode, like a bullseye. The two ring electrodes electrochemically lower and tune the local pH around the center disk by producing and trapping hydrogen ions. A voltage applied to the center disk causes an electrochemical reaction to generate an ionic current from the disk into the water. The reaction rate can be sped up or down –– increasing or decreasing the ionic current — by tuning the local pH.  In other words, the pH controls, or gates, the disk’s ionic current in the aqueous solution, creating an ionic counterpart of the electronic transistor.

They then engineered the pH-gated ionic transistor in such a way that the disk current is an arithmetic multiplication of the disk voltage and a “weight” parameter representing the local pH gating the transistor. They organized these transistors into a 16 × 16 array to expand the analog arithmetic multiplication of individual transistors into an analog matrix multiplication, with the array of local pH values serving as a weight matrix encountered in neural networks.

“Matrix multiplication is the most prevalent calculation in neural networks for artificial intelligence,” said Woo-Bin Jung, a postdoctoral fellow at SEAS and the first author of the paper. “Our ionic circuit performs the matrix multiplication in water in an analog manner that is based fully on electrochemical machinery.”

“Microprocessors manipulate electrons in a digital fashion to perform matrix multiplication,” said Donhee Ham, the Gordon McKay Professor of Electrical Engineering and Applied Physics at SEAS and the senior author of the paper. “While our ionic circuit cannot be as fast or accurate as the digital microprocessors, the electrochemical matrix multiplication in water is charming in its own right, and has a potential to be energy efficient.”

Now, the team looks to enrich the chemical complexity of the system.

“So far, we have used only 3 to 4 ionic species, such as hydrogen and quinone ions, to enable the gating and ionic transport in the aqueous ionic transistor,” said Jung. “It will be very interesting to employ more diverse ionic species and to see how we can exploit them to make rich the contents of information to be processed.”

The research was co-authored by Han Sae Jung, Jun Wang, Henry Hinton, Maxime Fournier, Adrian Horgan, Xavier Godron, and Robert Nicol. It was supported in part by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA), under grant 2019-19081900002.

Here’s a link to and a citation for the paper,

An Aqueous Analog MAC Machine by Woo-Bin Jung, Han Sae Jung, Jun Wang, Henry Hinton, Maxime Fournier, Adrian Horgan, Xavier Godron, Robert Nicol, Donhee Ham. Advanced Materials DOI: https://doi.org/10.1002/adma.202205096 First published online: 23 August 2022

This paper is behind a paywall.

As for the biotech startup mentioned as a collaborative partner in the research, DNA Script can be found here.

Ars Scientia talks at the University of British Columbia (UBC) in February, March, and April 2023

The University of British Columbia (UBC; Vancouver, Canada) partnership between its Stewart Blusson Quantum Matter Institute (Blusson QMI), its Morris & Helen Belkin Art Gallery (the Belkin), and its Department of Physics and Astronomy (UBC PHAS) is known as Ars Scientia. (See my September 6, 2021 posting for more; scroll down to the Ars Scientia subhead.)

It’s been a while since I’ve seen any notices about Ars Scientia events but the Belkin Gallery announced three in a February 15, 2023 notice (received via email),

Ars Scientia Artist Talks

Room 311, Brimacombe Building, 2355 East Mall, UBC

Join us for a series of artist talks hosted at UBC’s Stewart Blusson Quantum Matter Institute (Blusson QMI). Our current cohort of Ars Scientia artists-in-residence have formed collaborative partnerships with scientists and engineers while embedded at Blusson QMI.

Tuesday, February 21 [2023] at 2 pm

JG Mair

Tuesday, March 28 [2023] at 1 pm

Scott Billings

Tuesday, April 2 [2023] at 2 pm

Timothy Taylor

IMAGE (ABOVE): AN ARS SCIENTIA COLLABORATION BETWEEN VISUAL ARTIST JG MAIR AND PHYSICIST ALANNAH HALLAS AT BLUSSON QMI; THE TWO WORKED TOGETHER IN HALLAS’S LAB TO TURN “INSIGHTFUL FAILURES” OF HIGH-ENTROPY OXIDES (A TYPE OF QUANTUM MATERIAL) INTO AN ARTIST’S MEDIUM – PAINT. PHOTO: RACHEL TOPHAM PHOTOGRAPHY.

I have found more details about the upcoming talk here on the Belkin Gallery’s Artist Talks: JG Mair, Scott Billings and Timothy Taylor events page,

Artist Talk with JG Mair, Tuesday, 21 February [2023] at 2 pm

Please join visual and media artist JG Mair for a discussion about his art practice and experiences as a collaborative participant in the Ars Scientia residency. As part of his talk, Mair will present one of his major works, Chroma Chamber, a web-based new media art installation that investigates human expectations of vision and machine algorithms by programmatically collating real-time Google image results to surround the viewer with the distilled colour of the words they speak. Visit Blusson QMI for more details. [Note 1: On the Blusson QMI page, the talk is titled: Algorithmic allegories by JG Mair; Note 2: You’ll find a map showing the Brimacombe building location.]

I wasn’t able to find out more about the other talks but I did get more information about the three artists, Belkin Gallery’s Artist Talks: JG Mair, Scott Billings and Timothy Taylor events page.

JG Mair is a Vancouver-based multidisciplinary artist and media designer specializing in mixed media, web and audio. He has a BFA from the University of Victoria and a BEd from the University of British Columbia. Mair has been working in the areas of both traditional and digital contemporary art and as a sound designer for various game studios developing titles for publishers including Apple, Electronic Arts, Microsoft and Netflix. Mair has had exhibitions and residencies in Canada, USA, South Korea and Japan.

Scott Billings is a visual artist, industrial designer and engineer based in Vancouver. His sculptures and video installations have been described as existing somewhere between cinema and automata. Centering on issues of animality, mobility and spectatorship, Billings’s work examines the mimetic relationship between the physical apparatus and the virtual motion it delivers. In what ways does the apparatus itself reveal both the mechanisms of causality and its own dormant animal quality? Billings addresses this question under the pursuit of the technological conundrum and a preoccupation with precise geometry and logic. Billings holds an MFA from the University of British Columbia, a BFA from Emily Carr University and a BASc in Mechanical Engineering from the University of Waterloo. He teaches at UBC and Emily Carr as a sessional instructor. Billings is represented by Wil Aballe Art Projects.

Timothy Taylor is an Associate Professor and Graduate Advisor at the School of Creative Writing. He is also a bestselling and award-winning author of eight book-length works of fiction and nonfiction, a prolific journalist, and creative nonfiction writer. In addition to his writing and teaching at UBC, Taylor travels widely, having in recent years spent time on assignment in China, Tibet, Japan, Dubai, Brazil, the Canadian arctic and other places. He lives in Point Grey Vancouver with his wife, his son, and a pair of Brittany Spaniels named Keaton and Murphy.

Hopefully, the talk is a little more accessible than its description.

BSB Nanotechnology, silicon dioxide nanoparticles (SiO2), and Dow

Silicon dioxide (a form of silicon) is more commonly known as silica. There are problems with our use of *silica and so it was interesting to see this announcement (from a September 21, 2022 Dow news release on csiwire.com),

MIDLAND, Mich., September 21, 2022 /CSRwire/ – Dow (NYSE: Dow) announced a new engagement with BSB Nanotechnology Joint Stock Company, the world’s first producer of premium rice husk-based specialty silica. Rice husk, a renewable resource produced as a waste product of rice milling, is used for a plethora of diverse applications in the personal care market. This engagement helps accelerate Dow’s commitment towards a bio-based offering. The newly added ingredient – sold under the Dow trademark EcoSmooth™ Rice Husk Cosmetic Powder – delivers optical benefits and a unique sensorial experience for consumers in skin care, hair care and color cosmetic applications.

“Dow’s partnership with BSB Nanotechnology shines a light on how we continue to deliver on our commitment to transition towards a circular and low-carbon personal care offering while fostering valuable relationships with industry trailblazers,” said Isabel Almiro do Vale, global marketing and strategy director for Dow Personal Care. “This partnership is another significant milestone allowing Dow to expand its portfolio of products that enable eco-conscious claims, prioritizing solutions that deliver high-quality, benefits backed by science.”

The product of choice for the eco-conscious consumer, the EcoSmooth™ Rice Husk Cosmetic Powder is the exclusive ingredient to make its debut between the two parties. Compiled from non-GMO natural sources, this silica powder is upcycled from rice husk, a by-product from agriculture. It delivers a smooth feel combined with optical benefits like blurring imperfections and mattifying skin.

“This agreement signifies not only the first step towards a collaboration between Dow and BSB in the personal care sector but has also opened new pathways to other business sectors within Dow where BSB’s bio-based rice husk silica can offer sustainability and multifunctionality,” said Hung Nguyen, CEO of BSB. “BSB will continue to create more innovative and green solutions for the world and offer these additives through global partners like Dow.”

About Dow Personal Care Solutions

Dow Personal Care offers unique, innovative ingredients that empower customers around the world to create products with exceptional performance and exciting benefits that consumers can trust and believe in. Consumers that seek the confidence of a healthy appearance can see and feel the difference in our products through their lustrous hair or radiant and protected skin. We leverage our understanding of customer needs, deep market knowledge and technical expertise—combined with one of the broadest portfolios of technologies—to deliver personal care solutions with outstanding performance that are safe for people and the planet. We foster these innovations on global and local levels to meet the needs of diverse consumers through business centers, research and development (R&D), manufacturing plants and customer applications centers around the world. Please visit for more information.

About Dow

Dow (NYSE: DOW) combines global breadth; asset integration and scale; focused innovation and materials science expertise; leading business positions; and environmental, social and governance (ESG) leadership to achieve profitable growth and deliver a sustainable future. The Company’s ambition is to become the most innovative, customer centric, inclusive and sustainable materials science company in the world. Dow’s portfolio of plastics, industrial intermediates, coatings and silicones businesses delivers a broad range of differentiated, science-based products and solutions for its customers in high-growth market segments, such as packaging, infrastructure, mobility and consumer applications. Dow operates 104 manufacturing sites in 31 countries and employs approximately 35,700 people. Dow delivered sales of approximately $55 billion in 2021. References to Dow or the Company mean Dow Inc. and its subsidiaries. For more information, please visit www.dow.com or follow @DowNewsroom on Twitter.

About BSB Nanotechnology

BSB Nanotechnology Joint Stock Company, an established multi-faceted business, forayed into the rice world through the formulation of rice-based milk, a widely popular beverage in Vietnam. Strategically located in the Mekong Delta, the rice basket of Vietnam, BSB Nanotech taps into the country’s position as the 5th largest rice producer to access the main ingredient to its healthy beverage product. While feeding this nutritious gift of nature to the people of Vietnam, BSB Nanotech was presented with large amounts of rice husk, a waste product of rice milling. Building upon the business principle of reducing waste by reuse, BSB Nanotech has embarked on a journey to discover and create the value that rice husk could offer through its range of premium rice husk silica under the brand Biosilico. For more information, visit www.biosilico.vn .

I’m quite taken with BSB Nanotechnology’s Biosilico About page,

THE JOURNEY FROM ASH TO CASH

BSB Nanotechnology Joint Stock Company, an established multi-faceted business, forayed into the rice world through the formulation of rice-based milk, a widely popular beverage in Vietnam. Strategically located in the Mekong Delta, the rice basket of Vietnam, BSB Nanotech taps into the country’s  position as the 5th largest rice producer to access the main ingredient to its healthy beverage product. While feeding this nutritious gift of nature to the people of Vietnam, BSB Nanotech was presented with large amounts of rice husk, a waste product of rice milling. Building upon the business principle of reducing waste by reuse, BSB Nanotech has embarked on a journey to discover the value that rice husk could offer.

In the attempt to derive by-products from rice husk, BSB Nanotech learns that the most significant value held within rice husk ash is the high content of naturally present silica. Currently, sand and quartz are the only other naturally occurring silica sources. However, extracting silica from sand and quartz not only causes health hazards, but sand mining by itself presents a huge ecological and sociological problem. The utilization of rice husk ash to produce nanoporous silica is a positive step towards both a bio-based and circular economy, as ultrafine silica/nanosilica can be manufactured from this renewable resource and agricultural waste.

After 4 years of extensive research and development, a highly dedicated team of researchers of BSB Nanotech has successfully harnessed amorphous silica in its highest purity and quality from this waste material using a unique and patented technology. A new bio-based nanoporous silica under the BIOSILICO brand is now commercially available and can be customized to suit an array of applications.

OUR PROMISE TODAY FOR A BETTER TOMORROW

Today, BSB Nanotech is recognized as the world’s first producer of rice husk based nanoporous silica on a commercial scale. We are currently working with several global partners to expand the range of BIOSILICO’s applications from the Paints and Coatings to Rubber additives and Cosmetics industries.

To ensure that our products are delivered with its promised quality and committed schedule, BSB Nanotech undertook rigorous training and auditing to refine its operation, and production process and documentation to achieve the ISO [International Standards Organisation] QMS certification in 2020.

The company has embarked on a roadmap to become a global producer and developer of rice husk based nanoporous silica in both production volume and diverse applications.

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Maybe one of these days we’ll see BSB Nanotechnology at the annual Zero Waste Conference held here in Vancouver (Canada) during the autumn.

*See my July 10, 2014 posting scroll down [about 10%] to the University of California at Riverside news release for difficulties of working with silicon at the nanoscale, then scroll down about 40% to the discussion of Sand Wars, a documentary about how our appetite for silica (silicon dioxide) is depleting our beaches of sand.*

Studying quantum conductance in memristive devices

A September 27, 2022 news item on phys.org provides an introduction to the later discussion of quantum effects in memristors,

At the nanoscale, the laws of classical physics suddenly become inadequate to explain the behavior of matter. It is precisely at this juncture that quantum theory comes into play, effectively describing the physical phenomena characteristic of the atomic and subatomic world. Thanks to the different behavior of matter on these length and energy scales, it is possible to develop new materials, devices and technologies based on quantum effects, which could yield a real quantum revolution that promises to innovate areas such as cryptography, telecommunications and computation.

The physics of very small objects, already at the basis of many technologies that we use today, is intrinsically linked to the world of nanotechnologies, the branch of applied science dealing with the control of matter at the nanometer scale (a nanometer is one billionth of a meter). This control of matter at the nanoscale is at the basis of the development of new electronic devices.

A September 27, 2022 Istituto Nazionale di Ricerca Metrologica (INRIM) press release (summary, PDF, and also on EurekAlert), which originated the news item, provides more information about the research,

Among these, memrisistors are considered promising devices for the realization of new computational architectures emulating functions of our brain, allowing the creation of increasingly efficient computation systems suitable for the development of the entire artificial intelligence sector, as recently shown by INRiM researchers in collaboration with several international universities and research institutes [1,2].

In this context, the EMPIR MEMQuD project, coordinated by INRiM, aims to study the quantum effects in such devices in which the electronic conduction properties can be manipulated allowing the observation of quantized conductivity phenomena at room temperature. In addition to analyzing the fundamentals and recent developments, the review work “Quantum Conductance in Memristive Devices: Fundamentals, Developments, and Applications” recently published in the prestigious international journal Advanced Materials (https://doi.org/10.1002/adma.202201248) analyzes how these effects can be used for a wide range of applications, from metrology to the development of next-generation memories and artificial intelligence.

Here’s a link to and a citation for the paper,

Quantum Conductance in Memristive Devices: Fundamentals, Developments, and Applications by Gianluca Milano, Masakazu Aono, Luca Boarino, Umberto Celano, Tsuyoshi Hasegawa, Michael Kozicki, Sayani Majumdar, Mariela Menghini, Enrique Miranda, Carlo Ricciardi, Stefan Tappertzhofen, Kazuya Terabe, Ilia Valov. Advanced Materials Volume 34, Issue32 August 11, 2022 2201248 DOI: https://doi.org/10.1002/adma.202201248 First published: 11 April 2022

This paper is open access.

You can find the EMPIR (European Metrology Programme for Innovation and Research) MEMQuD (quantum effects in memristive devices) project here, from the homepage,

Memristive devices are electrical resistance switches that couple ionics (i.e. dynamics of ions) with electronics. These devices offer a promising platform to observe quantum effects in air, at room temperature, and without an applied magnetic field. For this reason, they can be traced to fundamental physics constants fixed in the revised International System of Units (SI) for the realization of a quantum-based standard of resistance. However, as an emerging technology, memristive devices lack standardization and insights into the fundamental physics underlying its working principles.

The overall aim of the project is to investigate and exploit quantized conductance effects in memristive devices that operate reliably, in air and at room temperature. In particular, the project will focus on the development of memristive model systems and nanometrological characterization techniques at the nanoscale level of memristive devices, in order to better understand and control the quantized effects in memristive devices. Such an outcome would enable not only the development of neuromorphic systems but also the realization of a standard of resistance implementable on-chip for self-calibrating systems with zero-chain traceability in the spirit of the revised SI.

I’m starting to see mention of ‘neuromorphic computing’ in advertisements (specifically a Mercedes Benz car). I will have more about these first mentions of neuromorphic computing in consumer products in a future posting.