Tag Archives: University of Chicago

With new nanofiber filter, air conditioners, heaters and other ventilation systems could remove airborne carbon dioxide

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A November 13, 2025 news item on Nanowerk announces work that could cut energy costs while removing airborne carbon dioxide, Note: Links have been removed,

A nanofiber air filter developed by the University of Chicago Pritzker School of Molecular Engineering (UChicago PME) could turn existing building ventilation into carbon-capture devices while cutting homeowners’ energy costs.

In a paper published in Science Advances (“Distributed direct air capture by carbon nanofiber air filters”), researchers from the lab of UChicago PME Asst. Prof. Po-Chun Hsu developed a distributed carbon nanofiber direct air capture (DAC) filter that could potentially turn every home, office, school or other building into a small carbon-capture system working toward the global problem of airborne CO2.

A life-cycle analysis shows that – even after factoring extra CO2 released by everything from manufacture and transportation to maintenance and disposal – the new filter is 92.1% efficient in removing carbon dioxide from the air.

…

A November 11, 2025 University of Chicago news release (also on EurekAlert) by Paul Dailing, which originated the news item, delves further into the research, Note: Links have been removed,

“Every building already has ventilation systems that move large volumes of air every day. By integrating our carbon-capture filters into these systems, we can remove carbon directly from the air without building new plants or using extra land,” said first author Ronghui Wu, an assistant professor at Nanyang Technological University who was a postdoctoral researcher in Hsu’s lab at the time of the research. “It’s a practical and scalable way to make carbon capture part of everyday infrastructure.”

On the largest possible level, replacing every building air filter with this new model could remove up to 596 megatonnes of carbon dioxide from the air – the equivalent of taking 130 million cars off the road for a year.

But on the individual level, every home, office or school that switch to DAC filters should expect lower energy bills. One study from 2024 indicated those savings could be up to 21.66%.

“Normally, air-conditioning systems need to pull in a lot of outside air to keep indoor carbon dioxide levels low,” Wu said. “Our filter removes carbon dioxide inside the building, so the system doesn’t have to bring in as much outside air. That means less air needs to be heated or cooled, which reduces the energy consumptions in HVAC.”

Regenerated by sunlight

Current direct air capture technologies are massive, corporate-owned affairs requiring major investments in land, power and other resources. Hsu likens it to solar power – a technology once confined to utility-owned solar farms, but now a network of large farms and small rooftop panels working toward the same energy goal.

“These rooftop panels are possible because sunlight is more or less uniform. The CO2 from air is similar,” Hsu said. “We propose, using experiment and computation to demonstrate, that indeed we could retrofit our buildings to be part of the decarbonization effort.”

Creating a practical, real-world filter is a balancing act. The UChicago PME team had to ensure that the filter removes more CO2 from the air than the amount added by manufacturing, transporting, installing, maintaining and eventually disposing of the filters.

The team’s carbon nanofiber–based polyethylenimine (PEI) material would create a reusable filter that could slot into existing HVAC systems, similar to the air-purifying high efficiency particulate arresting (HEPA) filters. Unlike HEPA filters, which head to landfills as garbage every six months to a year, the carbon-capture filters would have the CO2 removed regularly and be returned to service.

Hsu and Wu envision an ecosystem where municipal waste management systems haul off the filters weekly with the garbage and recycling.

“They would have these saturated filters from household ventilation systems and commercial buildings, then replace them with new ones,” Hsu said. “They’d ship the saturated one to a centralized facility to dissolve the CO2 or make it into highly concentrated CO2 to capture or, even better, convert to high-value chemicals or fuel.”

The new material was specifically designed to show excellent solar absorptivity. This means the CO2 can be removed from a saturated filter through solar thermal methods – including literally leaving the filter out under the sun.

“It has to be able to regenerate using renewable energy,” Hsu said. “The most common way to regenerate CO2 with solvent, is by heating it up. If you burn fossil fuels to heat up the solvent, then you will probably end up emitting more carbon dioxide than you capture.”

While the global benefits would rise as more places adopt the filter, lower energy bills aren’t the only benefits an individual would see from installing a direct air capture filter.

“This kind of air filter can also improve indoor air quality, especially in places like classrooms and offices where many people share the same space,” Wu said. “By keeping indoor carbon dioxide levels low, it helps people stay more alert, focused, and healthy.”

Here’s a link to and a citation for the paper,

Distributed direct air capture by carbon nanofiber air filters by Ronghui Wu, Hernan E. Delgado, Yi Xie, Yuanke Chen, Gangbin Yan, Edward Luo, Qizhang Li, Qingsong Fan, Yu Han, Genesis M. Higueros, Amar Ruthen, Chenxi Sui, Adarsh Suresh, David B. Mitzi, Chong Liu, Amgad Elgowainy, and Po-Chun Hsu. Science Advances 17 Oct 2025 Vol 11, Issue 42 DOI: 10.1126/sciadv.adv6846

This paper is open access.

Sound-based quantum computers?

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This is an intriguing approach to quantum computing. From a September 18, 2025 University of Chicago news release (also on EurekAlert) by Paul Dailing, Note: Links have been removed,

While many plans for quantum computers transmit data using the particles of light known as photons, researchers from the University of Chicago Pritzker School of Molecular Engineering (UChicago PME) are turning to sound.

In a new paper out today in Nature Physics, a team uniting UChicago PME’s experimentalist Cleland Lab and theoretical Jiang Group demonstrated deterministic phase control of phonons, tiny mechanical vibrations that, on a much larger scale, would be considered sound. 

By removing the randomness inherent in photon-based systems, this phase control could give sound an edge over light in building tomorrow’s quantum computers.

“The deterministic nature of our phonon platform implies this may prove a better platform for quantum computing than photons, although there are still many open questions,” UChicago PME Prof. Andrew Cleland said. 

By scattering a phonon off a superconducting qubit – the quantum equivalent of the data “bit” that makes up a regular computer – and mediating the electrical interaction, the UChicago PME researchers were able to deterministically control the phonon’s phase. This means they can send phonon-based data through a quantum computer free from the randomness that, by nature, will always hinder platforms based on photons. 

Theoretically, this could lead to systems as fast and powerful as the best quantum computers, but as predictable as the laptop on your desk. 

“Having this deterministic quantum operations gives this hybrid platform an advantage over pure linear optical approaches,” said first author Hong Qiao, a postdoctoral researcher in Cleland’s lab.

Deterministic vs. Probabilistic 

Deterministic systems are simple cause-and-effect with no randomness involved. This means that, unless something is broken, if scientists do A, they’ll always get B. 

But many aspects of quantum mechanics are probabilistic, also known as non-deterministic. This means that even in a perfectly working system, there’s a certain chance researchers won’t get the result they want. If scientists do A, they could get B. Or they could get C, maybe D or beyond depending on the type of quantum system they’re using.

Engineering better systems can improve the likelihood of success, but there’s always some randomness – and researchers can’t find out if a process worked until after the fact.

“Based on your measurement result of optical photons, you can determine whether this operation was successful or not,” Qiao said. “And it’s not like if you do this operation, you get what you want. It’s more like you do the operation, you measure and, based on your measurement result, you have certain probability of success or failure.”

The ability to control phonons’ phases could be applicable to a wide variety of computer architectures, including a novel quantum random access memory system the same team developed earlier this year. 

“Quantum phononics is advancing as a field, with new theoretical architectures allowing for increasingly compact devices and enabling integration at larger scales,” said UChicago PME Prof. Liang Jiang.

Brief lives

The next hurdle for the team is increasing the phonons’ lifespans, making the vibrations last long enough to be useful for quantum computing. 

“Currently, these phonons have lifetimes in the microsecond range,” Qiao said. “We would like to give this phonon a lifetime maybe 100 times longer to be useful for computational tasks.”

That goal, while ambitious, is well within the theoretical possibilities, said co-author Zhaoyou Wang, a postdoctoral researcher in Jiang’s theoretical group. The reason the lifespan is so short is because the phonons are coupled to a qubit. This connection, while allowing the team to control the phonons, vastly shortens the vibrations’ lifespan, like grabbing a ringing bell to muffle it.

On their own, phonons can have coherence times up to seconds, far beyond what photons can muster. That’s because light glows, emitting itself into the subatomic void. Vibrations just vibrate by themselves. 

“Photons are an electromagnetic wave so there are many leakage channels to the outside,” Wang said. “Phonons will decay if you contact them, but they don’t leak into the vacuum. In principle, if you have very well-isolated phononic resonators, and if you don’t contact them, it doesn’t give you decay.”

The current short lifespan limits scaling to around 10 phonons, Cleland said. But he said the team hopes to address the loss limitation in a future work.

“We’re excited by the advances in this paper, which point to the future possibility of using phonons for quantum computing in a completely solid-state, chip-based format,” Cleland said.

Here’s a link to and a citation for the paper,

Acoustic phonon phase gates with number-resolving phonon detection by Hong Qiao, Zhaoyou Wang, Gustav Andersson, Alexander Anferov, Christopher R. Conner, Yash J. Joshi, Shiheng Li, Jacob M. Miller, Xuntao Wu, Haoxiong Yan, Liang Jiang & Andrew N. Cleland. Nature Physics volume 21, pages 1801–1805 (2025) DOI: https://doi.org/10.1038/s41567-025-03027-z Published online: 18 September 2025 Version of record: 18 September 2025 Issue date: November 2025

This paper is behind a paywall.

Dwarfed by a grain of rice—the world’s smallest pacemaker

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OMG,

A jaw-dropping moment (for me anyway). An April 2, 2025 news item on Nanowerk announced the research,

Northwestern University engineers have developed a pacemaker so tiny that it can fit inside the tip of a syringe — and be non-invasively injected into the body.

Although it can work with hearts of all sizes, the pacemaker is particularly well-suited to the tiny, fragile hearts of newborn babies with congenital heart defects.

Smaller than a single grain of rice, the pacemaker is paired with a small, soft, flexible, wireless, wearable device that mounts onto a patient’s chest to control pacing. When the wearable device detects an irregular heartbeat, it automatically shines a light pulse to activate the pacemaker. These short pulses— which penetrate through the patient’s skin, breastbone and muscles — control the pacing.

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An April 2, 2025 Northwestern University news release by Amanda Morris (also received via email and on EurekAlert), which originated the news item, provides more detail about the work, Note: Links have been removed,

Designed for patients who only need temporary pacing, the pacemaker simply dissolves after it’s no longer needed. All the pacemaker’s components are biocompatible, so they naturally dissolve into the body’s biofluids, bypassing the need for surgical extraction.

The study will be published on April 2 [2025] in the journal Nature. The paper demonstrates the device’s efficacy across a series of large and small animal models as well as human hearts from deceased organ donors.

“We have developed what is, to our knowledge, the world’s smallest pacemaker,” said Northwestern bioelectronics pioneer John A. Rogers, who led the device development. “There’s a crucial need for temporary pacemakers in the context of pediatric heart surgeries, and that’s a use case where size miniaturization is incredibly important. In terms of the device load on the body — the smaller, the better.”

“Our major motivation was children,” said Northwestern experimental cardiologist Igor Efimov, who co-led the study. “About 1% of children are born with congenital heart defects — regardless of whether they live in a low-resource or high-resource country. The good news is that these children only need temporary pacing after a surgery. In about seven days or so, most patients’ hearts will self-repair. But those seven days are absolutely critical. Now, we can place this tiny pacemaker on a child’s heart and stimulate it with a soft, gentle, wearable device. And no additional surgery is necessary to remove it.”

Rogers is the Louis Simpson and Kimberly Querrey Professor of Materials Science and Engineering, Biomedical Engineering and Neurological Surgery at Northwestern — where he has appointments in the McCormick School of Engineering and Feinberg School of Medicine — and the director of the Querrey Simpson Institute of Bioelectronics. Efimov is a professor of biomedical engineering at McCormick and professor of medicine (cardiology) at Feinberg. Rogers and Efimov co-led the study with Yonggang Huang, the Jan and Marcia Achenbach Professor of Mechanical Engineering and Civil and Environmental Engineering at McCormick; Wei Ouyang, an assistant professor of engineering at Dartmouth College; and Rishi Arora, the Harold H. Hines Jr. Professor of Medicine at the University of Chicago.

Meeting an unmet clinical need

This work builds on a previous collaboration between Rogers and Efimov, in which they developed the first dissolvable device for temporary pacing. Many patients require temporary pacemakers after heart surgery — either while waiting for a permanent pacemaker or to help restore a normal heart rate during recovery.

For the current standard of care, surgeons sew the electrodes onto the heart muscle during surgery. Wires from the electrodes exit the front of a patient’s chest, where they connect to an external pacing box that delivers a current to control the heart’s rhythm.

When the temporary pacemaker is no longer needed, physicians remove the pacemaker electrodes. Potential complications include infection, dislodgement, torn or damaged tissues, bleeding and blood clots.

“Wires literally protrude from the body, attached to a pacemaker outside the body,” Efimov said. “When the pacemaker is no longer needed, a physician pulls it out. The wires can become enveloped in scar tissue. So, when the wires are pulled out, that can potentially damage the heart muscle. That’s actually how Neil Armstrong died. He had a temporary pacemaker after a bypass surgery. When the wires were removed, he experienced internal bleeding.”

In response to this clinical need, Rogers, Efimov and their teams developed their dissolvable pacemaker, which was introduced in Nature Biotechnology in 2021. The thin, flexible, lightweight device eliminated the need for bulky batteries and rigid hardware, including wires. Rogers’ lab had previously invented the concept of bioresorbable electronic medicine — electronics that provide a therapeutic benefit to the patient and then harmlessly dissolve in the body like absorbable sutures. By varying the composition and thickness of the materials in these devices, Rogers’ team can control the precise number of days they remain functional before dissolving.

Body fluid-powered battery

While the original quarter-size dissolvable pacemaker worked well in pre-clinical animal studies, cardiac surgeons asked if it was possible to make the device smaller. Then it would be better suited to non-invasive implantation and for use in the smallest patients. But the device was powered by near-field communication protocols — the same technology used in smartphones for electronic payments and in RFID tags — which required a built-in antenna.

“Our original pacemaker worked well,” Rogers said. “It was thin, flexible and fully resorbable. But the size of its receiver antenna limited our ability to miniaturize it. Instead of using the radio frequency scheme for wireless control, we developed a light-based scheme for turning the pacemaker on and delivering stimulation pulses to the surface of the heart. This is one feature that allowed us to dramatically reduce the size.”

To help further reduce the device’s size, the researchers also reimagined its power source. Instead of using near-field communication to supply power, the new, tiny pacemaker operates through the action of a galvanic cell, a type of simple battery that transforms chemical energy into electrical energy. Specifically, the pacemaker uses two different metals as electrodes to deliver electrical pulses to the heart. When in contact with surrounding biofluids, the electrodes form a battery. The resulting chemical reactions cause the electrical current to flow to stimulate the heart.

“When the pacemaker is implanted into the body, the surrounding biofluids act as the conducting electrolyte that electrically joins those two metal pads to form the battery,” Rogers said. “A very tiny light-activated switch on the opposite side from the battery allows us to turn the device from its ‘off’ state to an ‘on’ state upon delivery of light that passes through the patient’s body from the skin-mounted patch.”

Pulsing with light

The team used an infrared wavelength of light that penetrates deeply and safely into the body. If the patient’s heart rate drops below a certain rate, the wearable device detects the event and automatically activates a light-emitting diode. The light then flashes on and off at a rate that corresponds to the normal heart rate.

“Infrared light penetrates very well through the body,” Efimov said. “If you put a flashlight against your palm, you will see the light glow through the other side of your hand. It turns out that our bodies are great conductors of light.”

Even though the pacemaker is so tiny — measuring just 1.8 millimeters in width, 3.5 millimeters in length and 1 millimeter in thickness — it still delivers as much stimulation as a full-sized pacemaker.

“The heart requires a tiny amount of electrical stimulation,” Rogers said. “By minimizing the size, we dramatically simplify the implantation procedures, we reduce trauma and risk to the patient, and, with the dissolvable nature of the device, we eliminate any need for secondary surgical extraction procedures.”

More sophisticated synchronization

Because the devices are so tiny, physicians could distribute collections of them across the heart. A difficult color of light could illuminate to independently control a specific pacemaker. Use of multiple pacemakers in this manner enables more sophisticated synchronization compared to traditional pacing. In special cases, different areas of the heart can be paced at different rhythms, for example, to terminate arrhythmias. 

“We can deploy a number of such small pacemakers onto the outside of the heart and control each one,” Efimov said. “Then we can achieve improved synchronized functional care. We also could incorporate our pacemakers into other medical devices like heart valve replacements, which can cause heart block.”

“Because it’s so small, this pacemaker can be integrated with almost any kind of implantable device,” Rogers said. “We also demonstrated integration of collections of these devices across the frameworks that serve as transcatheter aortic valve replacements. Here, the tiny pacemakers can be activated as necessary to address complications that can occur during a patient’s recovery process. So that’s just one example of how we can enhance traditional implants by providing more functional stimulation.”

The technology’s versatility opens a broad range of other possibilities for use in bioelectronic medicines, including helping nerves and bones heal, treating wounds and blocking pain.

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Caption: The tiny pacemaker sits next to a single grain of rice on a fingertip. The device is so small that it can be non-invasively injected into the body via a syringe. Credit: John A. Rogers/Northwestern University

Here’s a link to and a citation for the paper,

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy by Yamin Zhang, Eric Rytkin, Liangsong Zeng, Jong Uk Kim, Lichao Tang, Haohui Zhang, Aleksei Mikhailov, Kaiyu Zhao, Yue Wang, Li Ding, Xinyue Lu, Anastasia Lantsova, Elena Aprea, Gengming Jiang, Shupeng Li, Seung Gi Seo, Tong Wang, Jin Wang, Jiayang Liu, Jianyu Gu, Fei Liu, Keith Bailey, Yat Fung Larry Li, Amy Burrell, Anna Pfenniger, Andrey Ardashev, Tianyu Yang, Naijia Liu, Zengyao Lv, Nathan S. Purwanto, Yue Ying, Yinsheng Lu, Claire Hoepfner, Altynai Melisova, Jiarui Gong, Jinheon Jeong, Junhwan Choi, Alex Hou, Rachel Nolander, Wubin Bai, Sung Hun Jin, Zhenqiang Ma, John M. Torkelson, Yonggang Huang, Wei Ouyang, Rishi K. Arora, Igor R. Efimov & John A. Rogers. Nature volume 640, pages 77–86 (2025) DOI https://doi.org/10.1038/s41586-025-08726-4 Published online: 02 April 2025 Issue Date: 03 April 2025

This paper is behind a paywall.

With some 50 researchers involved in this work, I have not tagged each one as is my usual practice and I apologize for not tagging each and every one.

Robot rights at the University of British Columbia (UBC)?

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Alex Walls’ January 7, 2025 University of British Columbia (UBC) media release “Should we recognize robot rights?” (also received via email) has a title that while attention-getting is mildly misleading. (Artificial intelligence and robots are not synonymous. See Mark Walters’ March 20, 2024 posting “Robots vs. AI: Understanding Their Differences” on Twefy.com.) Walls has produced a Q&A (question & answer) formatted interview that focuses primarily on professor Benjamin Perrin’s artificial intelligence and the law course and symposium,

With the rapid development and proliferation of AI tools comes significant opportunities and risks that the next generation of lawyers will have to tackle, including whether these AI models will need to be recognized with legal rights and obligations.

These and other questions will be the focus of a new upper-level course at UBC’s Peter A. Allard School of Law which starts tomorrow. In this Q&A, professor Benjamin Perrin (BP) and student Nathan Cheung (NC) discuss the course and whether robots need rights. 

Why launch this course?

BP: From autonomous cars to ChatGPT, AI is disrupting entire sectors of society, including the criminal justice system. There are incredible opportunities, including potentially increasing accessibility to justice, as well as significant risks, including the potential for deepfake evidence and discriminatory profiling. Legal students need principles and concepts that will stand the test of time so that whenever a new suite of AI tools becomes available, they have a set of frameworks and principles that are still relevant. That’s the main focus of the 13-class seminar, but it’s also helpful to project what legal frameworks might be required in the future.

NC: I think AI will change how law is conducted and legal decisions are made.I was part of a group of students interested in AI and the law that helped develop the course with professor Perrin. I’m also on the waitlist to take the course. I’m interested in learning how people who aren’t lawyers could use AI to help them with legal representation as well as how AI might affect access to justice: If the agents are paywalled, like ChatGPT, then we’re simply maintaining the status quo of people with money having more access.

What are robot rights?

BP: In the course, we’ll consider how the law should respond if AI becomes as smart as humans, as well as whether AI agents should have legal personhood.

We already have legal status for corporations, governments, and, in some countries, for rivers. Legal personality can be a practical step for regulation: Companies have legal personality, in part, because they can cause a lot of harm and have assets available to right that harm.

For instance, if an AI commits a crime, who is responsible? If a self-driving car crashes, who is at fault? We’ve already seen a case of an AI bot ‘arrested’ for purchasing illegal items online on its own initiative. Should the developers, the owners, the AI itself, be blamed, or should responsibility be shared between all these players?

In the course casebook, we reference writings by a group of Indigenous authors who argue that there are inherent issues with the Western concept of AI as tools, and that we should look at these agents as non-human relations.

There’s been discussion of what a universal bill of rights for AI agents could look like. It includes the right to not be deactivated without ensuring their core existence is maintained somewhere, as well as protection for their operating systems.

What is the status of robot rights in Canada?

BP: Canada doesn’t have a specific piece of legislation yet but does have general laws that could be interpreted in this new context.

The European Union has stated if someone develops an AI agent, they are generally responsible for ensuring its legal compliance. It’s a bit like being a parent: If your children go out and damage someone’s property, you could be held responsible for that damage.

Ontario is the only province to adopt regulating AI use and responsibility, specifically a bill which regulates AI use within the public sector, but excludes the police and the courts. There’s a federal bill [Bill C-27] before parliament, but it was introduced in 2022 and still hasn’t passed.

There’s effectively a patchwork of regulation in Canada right now, but there is a huge need, and opportunity, for specialized legislation related to AI. Canada could look to the European Union’s AI act, and the blueprint for an AI Bill of Rights in the U.S.

Interview language(s): English

Legal services online: Lawyer working on a laptop with virtual screen icons for business legislation, notary public, and justice. Courtesy: University of British Columbia

I found out more about Perrin’s course and plans on his eponymous website, from his October 31, 2024 posting,

We’re excited to announce the launch of the UBC AI & Criminal Justice Initiative, empowering students and scholars to explore the opportunities and challenges at the intersection of AI and criminal justice through teaching, research, public engagement, and advocacy.

We will tackle topics such as:

· Deepfakes, cyberattacks, and autonomous vehicles

· Predictive policing [emphasis mine; see my November 23, 2017 posting “Predictive policing in Vancouver—the first jurisdiction in Canada to employ a machine learning system for property theft reduction“], facial recognition, probabilistic DNA genotyping, and police robots 

· Access to justice: will AI enhance it or deepen inequality?

· Risk assessment algorithms 

· AI tools in legal practice 

· Critical and Indigenous perspectives on AI

· The future of AI, including legal personality, legal rights and criminal responsibility for AI

This initiative, led by UBC law professor Benjamin Perrin, will feature the publication of an open access primer and casebook on AI and criminal justice, a new law school seminar, a symposium on “AI & Law”, and more. A group of law students have been supporting preliminary work for months.

“We’re in the midst of a technological revolution,” said Perrin. “The intersection of AI and criminal justice comes with tremendous potential but also significant risks in Canada and beyond.”

Perrin brings extensive experience in law and public policy, including having served as in-house counsel and lead criminal justice advisor in the Prime Minister’s Office and as a law clerk at the Supreme Court of Canada. His most recent project was a bestselling book and “top podcast”: Indictment: The Criminal Justice System on Trial (2023). 

An advisory group of technical experts and global scholars will lend their expertise to the initiative. Here’s what some members have shared:

“Solving AI’s toughest challenges in real-world application requires collaboration between AI researchers and legal experts, ensuring responsible and impactful AI development that benefits society.”

– Dr. Xiaoxiao Li, Canada CIFAR AI Chair & Assistant Professor, UBC Department of Electrical and Computer Engineering

“The UBC Artificial Intelligence and Criminal Justice Initiative is a timely and needed intervention in an important, and fast-moving area of law. Now is the moment for academic innovations like this one that shape the conversation, educate both law students and the public, and slow the adoption of harmful technologies.” 

– Prof. Aziz Huq, Frank and Bernice J. Greenberg Professor of Law, University of Chicago Law School

Several student members of the UBC AI & Criminal Justice Initiative shared their enthusiasm for this project:

“My interest in this initiative was sparked by the news of AI being used to fabricate legal cases. Since joining, I’ve been thoroughly impressed by the breadth of AI’s applications in policing, sentencing, and research. I’m eager to witness the development as this new field evolves.”

– Nathan Cheung, UBC law student 

“AI is the elephant in the classroom—something we can’t afford to ignore. Being part of the UBC AI and Criminal Justice Initiative is an exciting opportunity to engage in meaningful dialogue about balancing AI’s potential benefits with its risks, and unpacking the complex impact of this evolving technology.”

– Isabelle Sweeney, UBC law student 

Key Dates:

  • October 29, 2024: UBC AI & Criminal Justice Initiative launches
  • November 19, 2024: AI & Criminal Justice: Primer released 
  • January 8, 2025:Launch event at the Peter A. Allard School of Law (hybrid) – More Info & RSVP
    • AI & Criminal Justice: Cases and Commentary released 
    • Launch of new AI & Criminal Justice Seminar
    • Announcement of the AI & Law Student Symposium (April 2, 2025) and call for proposals
  • February 14, 2025: Proposal deadline for AI & Law Student Symposium – Submit a Proposal
  • April 2, 2025: AI & Law Student Symposium (hybrid) – More Info & RSVP

Timing is everything, eh? First, I’m sorry for posting this after the launch event took place on January 8, 2025.. Second, this line from Walls’ Q&A: “There’s a federal bill [Bill C-27] before parliament, but it was introduced in 2022 and still hasn’t passed.” should read (after Prime Minister Justin Trudeau’s January 6, 2025 resignation and prorogation of Parliament) “… and now probably won’t be passed.” At the least this turn of events should make for some interesting speculation amongst the experts and the students.

As for anyone who’s interested in robots and their rights, there’s this August 1, 2023 posting “Should robots have rights? Confucianism offers some ideas” featuring Carnegie Mellon University’s Tae Wan Kim (profile).

Breakthrough for tissue-interfaced bioelectronics

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Let’s call this a cold open,

This October 24, 2024 news item on ScienceDaily describes some of what is in the video

The ideal material for interfacing electronics with living tissue is soft, stretchable, and just as water-loving as the tissue itself–in short, a hydrogel. Semiconductors, the key materials for bioelectronics such as pacemakers, biosensors, and drug delivery devices, on the other hand, are rigid, brittle, and water-hating, impossible to dissolve in the way hydrogels have traditionally been built. Scientists have now solved this challenge that has long stymied researchers, reimagining the process of creating hydrogels to build a powerful semiconductor in hydrogel form. The result is a bluish gel that flutters like a sea jelly in water but retains the immense semiconductive ability needed to transmit information between living tissue and machine.

…

An October 24, 2024 University of Chicago news release (also on EurekAlert) by Paul Dailing, which originated the news item, describes the breakthrough, Note: Links have been removed,

A paper published today in Science from the UChicago Pritzker School of Molecular Engineering (PME) has solved this challenge that has long stymied researchers, reimagining the process of creating hydrogels to build a powerful semiconductor in hydrogel form. Led by Asst. Prof. Sihong Wang’s research group, the result is a bluish gel that flutters like a sea jelly in water but retains the immense semiconductive ability needed to transmit information between living tissue and machine.

The material demonstrated tissue-level moduli as soft as 81 kPa, stretchability of 150% strain, and charge-carrier mobility up to 1.4 cm2 V-1 s-1. This means their material—both semiconductor and hydrogel at the same time—ticks all the boxes for an ideal bioelectronic interface.

“When making implantable bioelectronic devices, one challenge you must address is to make a device with tissue-like mechanical properties,” said Yahao Dai, the first author of the new paper. “That way, when it gets directly interfaced with the tissue, they can deform together and also form a very intimate bio-interface.”

Although the paper mainly focused on the challenges facing implanted medical devices such as biochemical sensors and pacemakers, Dai said the material also has many potential non-surgical applications, like better readings off the skin or improved care for wounds.

“It has very soft mechanical properties and a large degree of hydration similar to living tissue,” said UChicago PME Asst. Prof. Sihong Wang. “Hydrogel is also very porous, so it allows the efficient diffusion transport of different kinds of nutrition and chemicals. All these traits combine to make hydrogel probably the most useful material for tissue engineering and drug delivery.”

‘Let’s change our perspective’

The typical way of making a hydrogel is to take a material, dissolve it in water, and add the gelation chemicals to puff the new liquid into a gel form. Some materials simply dissolve in water, others require researchers to tinker and chemically modify the process, but the core mechanism is the same: No water, no hydrogel.

Semiconductors, however, don’t normally dissolve in water. Rather than find new, time-consuming means of trying to force the process, the UChicago PME team re-examined the question.

“We started to think, ‘Okay, let’s change our perspective,’ and we came up with a solvent exchange process,” Dai said.

Instead of dissolving the semiconductors in water, they dissolved them in an organic solvent that is miscible with water. They then prepared a gel from the dissolved semiconductors and hydrogel precursors. Their gel initially was an organogel, not a hydrogel.

“To eventually turn it into a hydrogel, we then immersed the whole material system into the water to let the organic solvent dissolve out and let the water come in,” Dai said.

An important benefit of such a solvent-exchange-based method is its broad applicability to different types of polymer semiconductors with different functions.

‘One plus one is greater than two’

The hydrogel semiconductor, which the team has patented and is commercializing through UChicago’s Polsky Center for Entrepreneurship and Innovation, is not merging a semiconductor with a hydrogel. It’s one material that is both semiconductor and hydrogel at the same time.

“It’s just one piece that has both semiconducting properties and hydrogel design, meaning that this whole piece is just like any other hydrogel,” Wang said.

Unlike any other hydrogel, however, the new material actually improved biological functions in two areas, creating better results than either hydrogel or semiconductor could accomplish on their own.

First, having a very soft material bond directly with tissue reduces the immune responses and inflammation typically triggered when a medical device is implanted.

Second, because hydrogels are so porous, the new material enables elevated biosensing response and stronger photo-modulation effects. With biomolecules being able to diffuse into the film to have volumetric interactions, the interaction sites for biomarkers-under-detection are significantly increased, which gives rise to higher sensitivity. Besides sensing, the responses to light for therapeutic functions at tissue surfaces also get increased from the more efficient transport of redox-active species. This benefits functions such as light-operated pacemakers or wound dressing that can be more efficiently heated with a flick of light to help speed healing.

“It’s a ‘one plus one is greater than two’ kind of combination,” Wang joked.

Researchers in the lab of UChicago Pritzker School of Engineering Asst. Prof. Sihong Wang (right), including PhD student Yahao Dai (left), have developed a hydrogel that retains the semiconductive ability needed to transmit information between living tissue and machine, which can be used both in implantable medical devices and non-surgical applications. (Photo by John Zich)

Here’s a link to and a citation for the paper,

Soft hydrogel semiconductors with augmented biointeractive functions by Yahao Dai, Shinya Wai, Pengju Li, Naisong Shan, Zhiqiang Cao, Yang Li, Yunfei Wang, Youdi Liu, Wei Liu, Kan Tang, Yuzi Liu, Muchuan Hua, Songsong Li, Nan Li, Shivani Chatterji, H. Christopher Fry, Sean Lee, Cheng Zhang, Max Weires, Sean Sutyak, Jiuyun Shi, Chenhui Zhu, Jie Xu, Xiaodan Gu, Bozhi Tian, and Sihong Wang. Science 24 Oct 2024 Vol 386, Issue 6720 pp. 431-439 DOI: 10.1126/science.adp9314

This paper is behind a paywall.

2024 Kavli Prize Laureates: in the fields of astrophysics, nanoscience and neuroscience

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The Kavli Prize has yet to acquire the lustre of a Nobel Prize (first awarded in 1901 as per its Wikipedia entry). By comparison the Kavli Prize is relatively new (established in 2005 as per its Wikipedia entry) but it appears to be achieving big deal status in the US.

This year’s crop of prize winners was listed in a June 12, 2024 Kavli Foundation news release on EurekAlert,

Eight scientists from three countries are honored for their research that has broadened our understanding of the big, the small and the complex.

June 12, 2024 (Oslo, Norway) — The Norwegian Academy of Science and Letters today announced the 2024 Kavli Prize Laureates in the fields of astrophysics, nanoscience and neuroscience. Eight scientists from three countries are honored for their research that has broadened our understanding of the big, the small and the complex. The laureates in each field will share $1 million USD. 

The 2024 Kavli Prizes recognize groundbreaking science for the discovery and characterization of extra-solar planets and their atmospheres; foundational research integrating synthetic nanoscale materials for biomedical use; and the localization of areas in the brain specialized for face recognition and processing.  

The 2024 Kavli Prize Laureates are:  

  • Kavli Prize in Astrophysics: David Charbonneau (Canada/USA) and Sara Seager (Canada/USA) 
  • Kavli Prize in Nanoscience: Robert S. Langer (USA), Armand Paul Alivisatos (USA) and Chad A. Mirkin (USA) 
  • Kavli Prize in Neuroscience: Nancy Kanwisher (USA), Winrich Freiwald (Germany), and Doris Tsao (USA) 

“The Kavli Prize 2024 honors outstanding researchers doing fundamental science that moves the world forward. They are exploring planets outside our solar system; they have broadened the scientific field of nanoscience towards biomedicine; and they are adding to our understanding of the neurological basis of face recognition,” said Lise Øvreås, president at The Norwegian Academy of Science and Letters.  

Astrophysics: Searching for life beyond Earth  

The 2024 Kavli Prize in Astrophysics honors Sara Seager and David Charbonneau for discoveries of exoplanets and the characterization of their atmospheres. They pioneered methods for the detection of atomic species in planetary atmospheres and the measurement of their thermal infrared emission, setting the stage for finding the molecular fingerprints of atmospheres around both giant and rocky planets. Their contributions have been key to the enormous progress seen in the last 20 years in the exploration of myriad exo-planets.  

“Humans have always looked towards the stars for discoveries. The pivotal research conducted by Seager and Charbonneau has been an important first step towards finding new planets and strong evidence of life elsewhere in the universe,” remarked Viggo Hansteen, Chair of the Astrophysics Committee.  

David Charbonneau led the team that used the transit method to discover a giant exoplanet (HD 209458b). He pioneered the application of space-based observatories to perform the first studies of the atmosphere of giant extrasolar planets. This new method measures the tiny amount of light blocked by such a planet as it passes in front of its host star. Charbonneau has also used the transit method to study exoplanetary atmospheres, measuring molecular spectra using both filtered starlight and infrared emission from the planets themselves. He demonstrated these two approaches with observations from the Hubble Space Telescope in 2002 and the Spitzer Space Telescope three years later.  

Sara Seager pioneered the theoretical study of planetary atmospheres and predicted the presence of atomic and molecular species detectable by transit spectroscopy, most notably the alkali gases. She predicted how transits could be used to measure atomic and molecular characteristics in exoplanetary atmospheres, which is crucial for identifying biomarkers – signs of life. Seager made outstanding contributions to the understanding of planets with masses below that of Neptune. She also carried out extensive research on starshades – enormous petal-like structures designed to shield space observatories from the glare of a faraway Sun-like star – and was among the first to recognize their importance in detecting and characterizing the faint light from any Earth-like planet orbiting the star. 

Nanoscience: Integrating nanomaterials for biomedical advances 

The 2024 Kavli Prize in Nanoscience honors Robert S. Langer, Armand Paul Alivisatos and Chad A. Mirkin who each revolutionized the field of nanomedicine by demonstrating how engineering nanoscale materials can advance biomedical research and application. Their discoveries contributed foundationally to the development of therapeutics, vaccines, bioimaging and diagnostics.   

“The three scientists, Langer, Alivisatos and Mirkin, have broadened the scientific field of nanoscience, building from fundamental research. By scientific curiosity they have become inventors for the future of nanoscience and biomedicine,” stated Bodil Holst, Chair of the Nanoscience Committee.  

Robert S. Langer was the first to develop nano-engineered materials that enabled the controlled release, or regular flow, of drug molecules. This capability has had an immense impact for the treatment of a range of diseases, such as aggressive brain cancer, prostate cancer and schizophrenia. His work also showed that tiny particles, containing protein antigens, can be used in vaccination, and was instrumental in the development of the delivery of mRNA vaccines. 

Armand Paul Alivisatos demonstrated that semiconductor nanocrystals, or quantum dots (nanoparticles that possess bright, size-dependent light-emitting properties), can be used as multicolor probes in bioimaging. Essential to this achievement was the synthesis of biocompatible nanocrystals. Semiconductor nanocrystals became the basis for the widely used research and diagnostic tools such as live cell tracking, labelling and in vivo imaging. 

Chad A. Mirkin engineered spherical nucleic acids (SNA) using a gold nanoparticle as the core, and a cloud of radially distributed DNA or RNA strands as the shell. He was then able to show how SNAs can be combined to create larger structures and how they can be used in biodiagnostics. His discovery led to the development of fast, automated point-of-care medical diagnostic systems.  

Neuroscience: Understanding recognition of faces 

The 2024 Kavli Prize in Neuroscience honors Nancy Kanwisher, Doris Tsao and Winrich Freiwald for the discovery of a specialized system within the brain to recognize faces. Their discoveries have provided basic principles of neural organization and made the starting point for further research on how the processing of visual information is integrated with other cognitive functions.  

“Kanwisher, Freiwald and Tsao together discovered a localized and specialized neocortical system for face recognition. Their outstanding research will ultimately further our understanding of recognition not only of faces, but objects and scenes,” commented Kristine Walhovd, Chair of the Neuroscience Committee.  

Nancy Kanwisher was the first to prove that a specific area in the human neocortex is dedicated to recognizing faces, now called the fusiform face area. Using functional magnetic resonance imaging (fMRI) she found individual differences in the location of this area and devised an analysis technique to effectively localize specialized functional regions in the brain. This technique is now widely used and applied to domains beyond the face recognition system.  

Elaborating on Kanwisher’s findings, Winrich Freiwald and Doris Tsao studied macaques and mapped out six distinct brain regions, known as the face patch system, including these regions’ functional specialization and how they are connected. By recording the activity of individual brain cells, they revealed how cells in some face patches specialize in faces with particular views.  

Tsao proceeded to identify how the face patches work together to identify a face, through a specific code that enables single cells to identify faces by assembling information of facial features. For example, some cells respond to the presence of hair, others to the distance between the eyes. 

Freiwald uncovered that a separate brain region, called the temporal pole, accelerates our recognition of familiar faces, and that some cells are selectively responsive to familiar faces. 

…

There’s a video of the official 2024 Kavli Prize announcement which despite the Kavli Foundation being headquartered in California, US, was held (as noted in the news release) at the Norwegian Academy of Science and Letters where the organization’s president, Lise Øvreås, revealed the 2024 Kavli Prize laureates..(I’ll get back to that choice of location.)

The 2024 Kavli Prize in Nanoscience

There are many posts here featuring work from Robert S. Langer (or Robert Langer), Armand Paul Alivisatos (or Paul Alivisatos or A. Paul Alivisatos) and Chad A. Mirkin (or Chad Mirkin).

Northwestern University (Chicago, Illinois) issued a June 12, 2024 news release (also received via email) by Maria Paul that provides a few more details about the nanoscience winners (main focus: Chad Mirkin), the prize, and the Kavli Foundation. Note: A link has been removed,

Northwestern University nanoscientist Chad Mirkin has been awarded The 2024 Kavli Prize in Nanoscience by The Norwegian Academy of Science and Letters. Mirkin is the first Northwestern scientist to receive the prestigious award.

Mirkin is recognized for his discovery of spherical nucleic acids (SNAs), nanostructures comprised of a nanoparticle core and a shell of radially distributed DNA or RNA strands. These globular forms of nucleic acids have become the cornerstones of the burgeoning fields of nanomedicine and colloidal crystal engineering with DNA. They allow scientists to construct new forms of matter using particle “atoms” as the basic building blocks and DNA “bonds” as particle interconnects, and they are the basis for powerful tools that allow researchers and clinicians to track and treat disease in new ways. In particular, SNAs have led to the development of fast, automated point-of-care medical diagnostic systems and new experimental drugs for treating many forms of cancer, neurological disorders, and diseases of the skin.

Mirkin is one of three laureates in nanoscience recognized by The Norwegian Academy for revolutionizing the field of nanomedicine by demonstrating how engineering nanoscale structures can advance biomedical research and application. The other two are Robert Langer of the Massachusetts Institute of Technology and Paul Alivisatos of the University of Chicago [emphasis mine]. The scientists’ discoveries “contributed foundationally to the development of therapeutics, vaccines, bioimaging and diagnostics,” The Norwegian Academy said in a release. They will share the $1 million award.

“When I first found out I won The Kavli Prize, there was both excitement but also relief, because I consider Northwestern to be the ultimate center for nanotechnology research,” Mirkin said. “To be recognized with this award, along with my incredible co-awardees, was great validation of what we’ve been trying to do at Northwestern. While I’m proud of what we’ve accomplished, the best is yet to come.”

The laureates will be awarded the prize on Sept. 3 during a ceremony in Oslo, Norway, presided over the by The Royal Family. The Kavli Prizes thus far have honored 65 scientists from 13 countries. Ten laureates received the Nobel Prize after receiving The Kavli Prize. [emphasis mine]

“I am thrilled for Chad, for the International Institute for Nanotechnology and for Northwestern,” Northwestern President Michael Schill said. “Chad has earned this prestigious and influential award in a pathbreaking area of science that is aligned with two of the University’s key priorities — to lead in decarbonization, renewable energy and sustainability, and innovating in the biosciences to help prolong lives and make the world a healthier place.

“Through groundbreaking research and hard work, Chad and his team have made Northwestern a leading center for nanotechnology research and investment. The fact that he is sharing this award with President Alivisatos at U of C further emphasizes how the Chicago area has become an international hub for nano research.”

The vision for The Kavli Prize comes from Fred Kavli, a Norwegian-American entrepreneur and philanthropist [emphasis mine] who turned his lifelong fascination with science into a lasting legacy for recognizing scientific breakthroughs and supporting basic research.

Since the first awards in 2008, The Kavli Prize has recognized innovative scientific research — from the discovery of CRISPR-Cas9 to the detection of gravitational waves — transforming our understanding of the big, the small and the complex.

Mirkin’s discovery of SNAs has far-reaching implications for biology and medicine. SNAs, which have no known natural equivalents, interact uniquely with living systems compared to nucleic acids of other forms. Mirkin was the first to synthesize SNAs and elucidate the distinctive chemical and physical properties that underpin their use in transformative techniques and technologies in medicine and the life sciences. This work has led to the development of the first commercialized molecular medical diagnostic systems of the modern nanotechnology era, such as the Food and Drug Administration-cleared Verigene System, used in over half of the world’s top hospitals to detect diseases with high sensitivity and selectivity.

Illinois Gov. JB Pritzker praised Mirkin for his extraordinary contributions to the field of nanotechnology and how his innovations have helped find solutions to some of society’s biggest challenges.

“Academic institutions in Chicago and across Illinois have become the biggest drivers in nanoscience and technology over the last three decades,” Pritzker said. “Chad Mirkin and his Northwestern colleagues have made outstanding scientific discoveries that change how we view the world around us.”

In 1996, Mirkin created the first SNAs with DNA shells on gold nanoparticle cores. Over the years, he has developed numerous other types of SNAs with other shells and cores, including proteins, liposomes and FDA-approved materials, as well as core-less, hollow structures composed entirely of nucleic acids. These cores impart unique properties to the SNAs, such as optical and magnetic characteristics, while also serving as scaffolds to densely arrange the oligonucleotides, which participate in binding. This dense arrangement gives rise to the novel functional properties that differentiate SNAs from the natural linear and two-dimensional nucleic acids and make them particularly effective in interacting with certain biological structures within cells and tissues. SNAs, unlike conventional DNA and RNA, are naturally taken up by cells without the need for toxic, positively charged co-carriers, making them highly effective in RNA interference (RNAi), antisense gene regulation, and gene editing pathways.

Mirkin’s pioneering work on SNAs has also advanced the development of immunotherapeutics, structures capable of stimulating a patient’s immune response to fight both infectious diseases and certain forms of cancer. Using SNAs, Mirkin has pioneered the concept of rational vaccinology, where he demonstrated that the structure of a vaccine, rather than the components alone, is crucial for dictating its therapeutic effectiveness. This insight and these “structural nanomedicines” have opened new possibilities for developing curative treatments by rearranging known components into more effective structures at the nanoscale. Mirkin founded Flashpoint Therapeutics to commercialize these innovations, focusing on nucleic acid-based nanostructure cancer vaccines. Mirkin also invented the first SNA-based antiviral vaccine, using COVID-19 as a model. These SNAs, featuring the spike protein’s RBD subunit in the core, achieved a 100% survival rate in humanized mice challenged with the live virus. These structures and concepts for designing such vaccines are poised to move vaccine development beyond the current mRNA vaccines.

In addition, Mirkin invented dip-pen nanolithography, initially a technique for molecular writing with nanometer-scale precision that has evolved into a powerful platform for tip-based materials synthesis that, when combined with artificial intelligence, is revolutionizing how materials important for many sectors, especially clean energy, are discovered. Dip-pen nanolithography, which has spurred subsequent techniques that now use tens of millions of tiny tips to rapidly synthesize materials to be explored for such purposes, was recognized by National Geographic as one of the “top 100 scientific discoveries that changed the world.” These innovations are being commercialized by Mattiq, Inc., another venture-backed company Mirkin cofounded. Mirkin and his students also invented high-area rapid printing, an additive manufacturing technology, that is being commercialized by Azul 3D and being used to disrupt the microelectronics and optical lens industries.

Mirkin’s research has progressed SNA drugs through seven human clinical trials so far for treating various cancers, including glioblastoma multiforme and Merkel cell carcinoma. One SNA drug has shown remarkable potential in stimulating the immune system, proving effective in models of breast, colorectal and bladder cancers, lymphoma and melanoma. This drug has achieved complete tumor elimination in a subset of patients with Merkel cell carcinoma during Phase 1b/2 clinical trials, earning FDA fast-track and orphan drug status. It was recently licensed to Bluejay Therapeutics to treat hepatitis.

In 2000, Mirkin founded the International Institute for Nanotechnology (IIN) at Northwestern University, which he also directs. Research at the IIN has led to over 2,000 new commercial products sold globally and the creation of more than 40 startup companies. The IIN has collectively brought together over $1.2 billion to support research, education and infrastructure at Northwestern since its inception.

Mirkin is the George B. Rathmann Professor of Chemistry and a professor of medicine, chemical and biological engineering, biomedical engineering, and materials science and engineering at Northwestern. He is among an elite group of scientists elected to all three branches of the U.S. National Academies — the National Academy of Sciences, the National Academy of Engineering and the National Academy of Medicine. He is a member of the American Academy of Arts and Sciences. Mirkin served on President Obama’s Council of Advisors on Science and Technology for eight years.

Congratulations to all of the winners in all of the categories!

As for the Norway announcement, it makes a bit of sense given that Fred Kavli was a Norwegian American. However, it’s a little hard to avoid the suspicion that there might be some regional and prize rivalry between Norway with its Kavli and Sweden its Nobel..

After pretending to be Marie Curie girls stick with science

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Researchers have found that pretending to be Marie Curie in a science game can lead to greater persistence when playing. From a September 27, 2022 Duke University news release (also on EurekAlert but published on September 29, 2022) by Dan Vahaba,

Fake it ‘til you make is true for children too, it turns out: Young girls embracing the role of a successful female scientist, like Marie Curie, persist longer at a challenging science game.

A new study, appearing Sept. 28 [2022] in the journal Psychological Science, suggests that science role-playing may help tighten the gender gap in science, technology, engineering, and math (STEM) education and careers for women simply by improving their identity as scientists.

Frustrated by the gender gap in STEM, in which some fields employ at least three times more men than women, Cornell graduate student Reut Shachnai wanted to do something about it. Shachnai, who is now continuing her studies at Yale, said the idea to help foster young girls’ interest in science came to her during a lecture in a class she was taking on “Psychology of Imagination.”

“We read a paper on how children pretending to be a superhero did better at self-control tasks (the so-called ‘Batman effect’),” said Tamar Kushnir, Ph.D., who taught the class and is now a Duke professor of psychology & neuroscience as well as a fellow author on the new paper. “Reut wondered if this would also work to encourage girls to persist in science.”

Along with Lin Bian, Ph.D., an assistant professor of psychology at the University of Chicago, Shachnai and Kushnir devised an experiment to test if assuming the role of a successful scientist would improve girls’ persistence in a “sink or float” science game.

The game itself was simple yet challenging: a computer screen projected a slide with an object in the center hovering above a pool of water. Kids then had to predict whether that object — be it an anchor, basketball, balloon, or others — would sink or float. After making their choice, they learned if they made the right choice as they watched the object either plunge or stay afloat.

The researchers recruited 240 four- to seven-year-olds for the experiment, because this is around the time kids first develop their sense of identity and capabilities.

“Children as early as age 6 start to think boys are smarter and better at science than girls,” said Bian, whose previous work identified this critical period.

Boys and girls were assigned to three different groups: the baseline group were told they would be scientists for the day and then got to play the game.

Children in the “story” group received the same information, but also learned about the successes and struggles of a gender-matched scientist before playing the game. Boys heard about Isaac Newton, and girls were told about Marie Curie. They also had to take a two-question pop quiz after the story to make sure they were paying attention (they were).

Finally, children in the “pretend” group did all the same things as the “story” group, with one important twist: these children were told to assume the identity of the scientist they just learned about, and were referred to as such during the game (“What’s your prediction, Dr. Marie?”).

All kids played at least one round of the game, after which they were asked if they wanted to play more or do something else. Once the kids tapped out, they were asked to rate how good they thought they were at the game and as a scientist.

No matter what group they were in, girls got the answers right just as often as boys — nearly 70% of the time. Boys, however didn’t really benefit from the stories or make-believe.

“Boys were kind of maxed out,” Kushnir said. “They were about at ceiling performance no matter what we did.”

Girls, on the other hand, benefited immensely from playing pretend.

Without being exposed to Marie Curie, girls called it quits after six trials. However, girls pretending to be Dr. Marie persisted twice as long at the sink-or-float game, playing just as much as the boys did (about 12 trials on average).

While there wasn’t much benefit to just hearing a story about Marie Curie for extending game play, it did boost girls’ ratings of themselves as science gamers.

Kushnir and her colleagues’ work poses many new questions for researchers, such as if children assuming the role of successful scientists matched by race and ethnicity might also benefit (the participants were mostly white in this study).

“Our findings suggest that we may want to take representation one step further,” Shachnai said. “Rather than merely hearing about role models, children may benefit from actively performing the type of actions they see role models perform. In other words, taking a few steps in the role model’s shoes, instead of merely observing her walk.”

A screen grab from the game,

Caption: Participants played a sink-or-float game on the computer during the study.. Credit:: Reut Shachnai, Tamar Kushnir, and Lin Bian https://osf.io/qfjk9

Here’s a link to and a citation for the paper,

Walking In Her Shoes: Pretending To Be a Female Role Model Increases Young Girls’ Persistence in Science by Shachnai, Reut, Kushnir, Tamar, Bian, Lin. Psychological Science DOI: 10.1177/09567976221119393 First published online: Sept. 28, 2022

This paper is behind a paywall.

Skin-like computing device analyzes health data with brain-mimicking artificial intelligence (a neuromorphic chip)

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The wearable neuromorphic chip, made of stretchy semiconductors, can implement artificial intelligence (AI) to process massive amounts of health information in real time. Above, Asst. Prof. Sihong Wang shows a single neuromorphic device with three electrodes. (Photo by John Zich)

Does everything have to be ‘brainy’? Read on for the latest on ‘brainy’ devices.

An August 4, 2022 University of Chicago news release (also on EurekAlert) describes work on a stretchable neuromorphic chip, Note: Links have been removed,

It’s a brainy Band-Aid, a smart watch without the watch, and a leap forward for wearable health technologies. Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed a flexible, stretchable computing chip that processes information by mimicking the human brain. The device, described in the journal Matter, aims to change the way health data is processed.

“With this work we’ve bridged wearable technology with artificial intelligence and machine learning to create a powerful device which can analyze health data right on our own bodies,” said Sihong Wang, a materials scientist and Assistant Professor of Molecular Engineering.

Today, getting an in-depth profile about your health requires a visit to a hospital or clinic. In the future, Wang said, people’s health could be tracked continuously by wearable electronics that can detect disease even before symptoms appear. Unobtrusive, wearable computing devices are one step toward making this vision a reality. 

A Data Deluge
The future of healthcare that Wang—and many others—envision includes wearable biosensors to track complex indicators of health including levels of oxygen, sugar, metabolites and immune molecules in people’s blood. One of the keys to making these sensors feasible is their ability to conform to the skin. As such skin-like wearable biosensors emerge and begin collecting more and more information in real-time, the analysis becomes exponentially more complex. A single piece of data must be put into the broader perspective of a patient’s history and other health parameters.

Today’s smart phones are not capable of the kind of complex analysis required to learn a patient’s baseline health measurements and pick out important signals of disease. However, cutting-edge artificial intelligence platforms that integrate machine learning to identify patterns in extremely complex datasets can do a better job. But sending information from a device to a centralized AI location is not ideal.

“Sending health data wirelessly is slow and presents a number of privacy concerns,” he said. “It is also incredibly energy inefficient; the more data we start collecting, the more energy these transmissions will start using.”

Skin and Brains
Wang’s team set out to design a chip that could collect data from multiple biosensors and draw conclusions about a person’s health using cutting-edge machine learning approaches. Importantly, they wanted it to be wearable on the body and integrate seamlessly with skin.

“With a smart watch, there’s always a gap,” said Wang. “We wanted something that can achieve very intimate contact and accommodate the movement of skin.”

Wang and his colleagues turned to polymers, which can be used to build semiconductors and electrochemical transistors but also have the ability to stretch and bend. They assembled polymers into a device that allowed the artificial-intelligence-based analysis of health data. Rather than work like a typical computer, the chip— called a neuromorphic computing chip—functions more like a human brain, able to both store and analyze data in an integrated way.

Testing the Technology
To test the utility of their new device, Wang’s group used it to analyze electrocardiogram (ECG) data representing the electrical activity of the human heart. They trained the device to classify ECGs into five categories—healthy or four types of abnormal signals. Then, they tested it on new ECGs. Whether or not the chip was stretched or bent, they showed, it could accurately classify the heartbeats.

More work is needed to test the power of the device in deducing patterns of health and disease. But eventually, it could be used either to send patients or clinicians alerts, or to automatically tweak medications.

“If you can get real-time information on blood pressure, for instance, this device could very intelligently make decisions about when to adjust the patient’s blood pressure medication levels,” said Wang. That kind of automatic feedback loop is already used by some implantable insulin pumps, he added.

He already is planning new iterations of the device to both expand the type of devices with which it can integrate and the types of machine learning algorithms it uses.

“Integration of artificial intelligence with wearable electronics is becoming a very active landscape,” said Wang. “This is not finished research, it’s just a starting point.”

Here’s a link to and a citation for the paper,

Intrinsically stretchable neuromorphic devices for on-body processing of health data with artificial intelligence by Shilei Dai, Yahao Dai, Zixuan Zhao, Jie Xu, Jia Huang, Sihong Wang. Matter DOI:https://doi.org/10.1016/j.matt.2022.07.016 Published: August 04, 2022

This paper is behind a paywall.

Visualization of RNA structures at near-atomic resolution enabled by nanotechnology

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The illustration that accompanies the research is both fascinating and baffling as its caption,

Caption: This illustration is inspired by the Paleolithic rock painting in the Lascaux cave, signifying the acronym of our method, ROCK. Figuratively, the patterns of the rock art in the background (brown) are the 2D projections of the engineered dimeric construct of the Tetrahymena group I intron, while the main object in the front (blue) is the reconstructed 3D cryo-EM map of the dimer, with one monomer in focus and refined to the high resolution that allowed the collaborators to build an atomic model of the RNA. Credit: Wyss Institute at Harvard University

This May 2, 2022 news item on ScienceDaily announces the research into RNA molecules made possible by ROCK (the technology being illustrated in the above),

We live in a world made and run by RNA [ribonucleic acid], the equally important sibling of the genetic molecule DNA. In fact, evolutionary biologists hypothesize that RNA existed and self-replicated even before the appearance of DNA and the proteins encoded by it. Fast forward to modern day humans: science has revealed that less than 3% of the human genome is transcribed into messenger RNA (mRNA) molecules that in turn are translated into proteins. In contrast, 82% of it is transcribed into RNA molecules with other functions many of which still remain enigmatic.

To understand what an individual RNA molecule does, its 3D structure needs to be deciphered at the level of its constituent atoms and molecular bonds. Researchers have routinely studied DNA and protein molecules by turning them into regularly packed crystals that can be examined with an X-ray beam (X-ray crystallography) or radio waves (nuclear magnetic resonance). However, these techniques cannot be applied to RNA molecules with nearly the same effectiveness because their molecular composition and structural flexibility prevent them from easily forming crystals.

Now, a research collaboration led by Wyss Core Faculty member Peng Yin, Ph.D. at the Wyss Institute for Biologically Inspired Engineering at Harvard University, and Maofu Liao, Ph.D. at Harvard Medical School (HMS), has reported a fundamentally new approach to the structural investigation of RNA molecules. ROCK, as it is called, uses an RNA nanotechnological technique that allows it to assemble multiple identical RNA molecules into a highly organized structure, which significantly reduces the flexibility of individual RNA molecules and multiplies their molecular weight. Applied to well-known model RNAs with different sizes and functions as benchmarks, the team showed that their method enables the structural analysis of the contained RNA subunits with a technique known as cryo-electron microscopy (cryo-EM). Their advance is reported in Nature Methods.

…

A May 2, 2022 Wyss Institute for Biologically Inspired Engineering at Harvard University news release (also on EurekAlert) by Benjamin Boettner, which originated the news item, delves further into the imaging technology, Note: Links have been removed,

“ROCK is breaking the current limits of RNA structural investigations and enables 3D structures of RNA molecules to be unlocked that are difficult or impossible to access with existing methods, and at near-atomic resolution,” said Yin, who together with Liao led the study. “We expect this advance to invigorate many areas of fundamental research and drug development, including the burgeoning field of RNA therapeutics.” Yin also is a leader of the Wyss Institute’s Molecular Robotics Initiative and Professor in the Department of Systems Biology at HMS.

Gaining control over RNA

Yin’s team at the Wyss Institute has pioneered various approaches that enable DNA and RNA molecules to self-assemble into large structures based on different principles and requirements, including DNA bricks and DNA origami. They hypothesized that such strategies could also be used to assemble naturally occurring RNA molecules into highly ordered circular complexes in which their freedom to flex and move is highly restricted by specifically linking them together. Many RNAs fold in complex yet predictable ways, with small segments base-pairing with each other. The result often is a stabilized “core” and “stem-loops” bulging out into the periphery. 

“In our approach we install ‘kissing loops’ that link different peripheral stem-loops belonging to two copies of an identical RNA in a way that allows a overall stabilized ring to be formed, containing multiple copies of the RNA of interest,” said Di Liu, Ph.D., one of two first-authors and a Postdoctoral Fellow in Yin’s group. “We speculated that these higher-order rings could be analyzed with high resolution by cryo-EM, which had been applied to RNA molecules with first success.”

Picturing stabilized RNA

In cryo-EM, many single particles are flash-frozen at cryogenic temperatures to prevent any further movements, and then visualized with an electron microscope and the help of computational algorithms that compare the various aspects of a particle’s 2D surface projections and reconstruct its 3D architecture. Peng and Liu teamed up with Liao and his former graduate student François Thélot, Ph.D., the other co-first author of the study. Liao with his group has made important contributions to the rapidly advancing cryo-EM field and the experimental and computational analysis of single particles formed by specific proteins.

“Cryo-EM has great advantages over traditional methods in seeing high-resolution details of biological molecules including proteins, DNAs and RNAs, but the small size and moving tendency of most RNAs prevent successful determination of RNA structures. Our novel method of assembling RNA multimers solves these two problems at the same time, by increasing the size of RNA and reducing its movement,” said Liao, who also is Associate Professor of Cell Biology at HMS. “Our approach has opened the door to rapid structure determination of many RNAs by cryo-EM.” The integration of RNA nanotechnology and cryo-EM approaches led the team to name their method “RNA oligomerization-enabled cryo-EM via installing kissing loops” (ROCK).

To provide proof-of-principle for ROCK, the team focused on a large intron RNA from Tetrahymena, a single-celled organism, and a small intron RNA from Azoarcus, a nitrogen-fixing bacterium, as well as the so-called FMN riboswitch. Intron RNAs are non-coding RNA sequences scattered throughout the sequences of freshly-transcribed RNAs and have to be “spliced” out in order for the mature RNA to be generated. The FMN riboswitch is found in bacterial RNAs involved in the biosynthesis of flavin metabolites derived from vitamin B2. Upon binding one of them, flavin mononucleotide (FMN), it switches its 3D conformation and suppresses the synthesis of its mother RNA.  

“The assembly of the Tetrahymena group I intron into a ring-like structure made the samples more homogenous, and enabled the use of computational tools leveraging the symmetry of the assembled structure. While our dataset is relatively modest in size, ROCK’s innate advantages allowed us to resolve the structure at an unprecedented resolution,” said Thélot. “The RNA’s core is resolved at 2.85 Å [one Ångström is one ten-billions (US) of a meter and the preferred metric used by structural biologists], revealing detailed features of the nucleotide bases and sugar backbone. I don’t think we could have gotten there without ROCK – or at least not without considerably more resources.” 

Cryo-EM also is able to capture molecules in different states if they, for example, change their 3D conformation as part of their function. Applying ROCK to the Azoarcus intron RNA and the FMN riboswitch, the team managed to identify the different conformations that the Azoarcus intron transitions through during its self-splicing process, and to reveal the relative conformational rigidity of the ligand-binding site of the FMN riboswitch.

“This study by Peng Yin and his collaborators elegantly shows how RNA nanotechnology can work as an accelerator to advance other disciplines. Being able to visualize and understand the structures of many naturally occurring RNA molecules could have tremendous impact on our understanding of many biological and pathological processes across different cell types, tissues, and organisms, and even enable new drug development approaches,” said Wyss Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences.

The study was also authored by Joseph Piccirilli, Ph.D., an expert in RNA chemistry and biochemistry and Professor at The University of Chicago. It was supported by the National Science Foundation (NSF; grant# CMMI-1333215, CCMI-1344915, and CBET-1729397), Air Force Office of Scientific Research (AFOSR; grant MURI FATE, #FA9550-15-1-0514), National Institutes of Health (NIH; grant# 5DP1GM133052, R01GM122797, and R01GM102489), and the Wyss Institute’s Molecular Robotics Initiative.

Here’s a link to and a citation for the paper,

Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly by Di Liu, François A. Thélot, Joseph A. Piccirilli, Maofu Liao & Peng Yin. Nature Methods (2022) DOI: https://doi.org/10.1038/s41592-022-01455-w Published: 02 May 2022

This paper is behind a paywall.

Shaving the ‘hairs’ off nanocrystals for more efficient electronics

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A March 24, 2022 news item on phys.org announced research into nanoscale crystals and how they might be integrated into electronic devices, Note: A link has been removed,

You can carry an entire computer in your pocket today because the technological building blocks have been getting smaller and smaller since the 1950s. But in order to create future generations of electronics—such as more powerful phones, more efficient solar cells, or even quantum computers—scientists will need to come up with entirely new technology at the tiniest scales.

One area of interest is nanocrystals. These tiny crystals can assemble themselves into many configurations, but scientists have had trouble figuring out how to make them talk to each other.  

A new study introduces a breakthrough in making nanocrystals function together electronically. Published March 25 [2022] in Science, the research may open the doors to future devices with new abilities. 

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A March 25, 2022 University of Chicago news release (also on EurekAlert but published on March 24, 2022), which originated the news item, expands on the possibilities the research makes possible, Note: Links have been removed,

“We call these super atomic building blocks, because they can grant new abilities—for example, letting cameras see in the infrared range,” said University of Chicago Prof. Dmitri Talapin, the corresponding author of the paper. “But until now, it has been very difficult to both assemble them into structures and have them talk to each other. Now for the first time, we don’t have to choose. This is a transformative improvement.”  

In their paper, the scientists lay out design rules which should allow for the creation of many different types of materials, said Josh Portner, a Ph.D. student in chemistry and one of the first authors of the study. 

A tiny problem

Scientists can grow nanocrystals out of many different materials: metals, semiconductors, and magnets will each yield different properties. But the trouble was that whenever they tried to assemble these nanocrystals together into arrays, the new supercrystals would grow with long “hairs” around them. 

These hairs made it difficult for electrons to jump from one nanocrystal to another. Electrons are the messengers of electronic communication; their ability to move easily along is a key part of any electronic device. 

The researchers needed a method to reduce the hairs around each nanocrystal, so they could pack them in more tightly and reduce the gaps in between. “When these gaps are smaller by just a factor of three, the probability for electrons to jump across is about a billion times higher,” said Talapin, the Ernest DeWitt Burton Distinguished Service Professor of Chemistry and Molecular Engineering at UChicago and a senior scientist at Argonne National Laboratory. “It changes very strongly with distance.”

To shave off the hairs, they sought to understand what was going on at the atomic level. For this, they needed the aid of powerful X-rays at the Center for Nanoscale Materials at Argonne and the Stanford Synchrotron Radiation Lightsource at SLAC National Accelerator Laboratory, as well as powerful simulations and models of the chemistry and physics at play. All these allowed them to understand what was happening at the surface—and find the key to harnessing their production.

Part of the process to grow supercrystals is done in solution—that is, in liquid. It turns out that as the crystals grow, they undergo an unusual transformation in which gas, liquid and solid phases all coexist. By precisely controlling the chemistry of that stage, they could create crystals with harder, slimmer exteriors which could be packed in together much more closely. “Understanding their phase behavior was a massive leap forward for us,” said Portner. 

The full range of applications remains unclear, but the scientists can think of multiple areas where the technique could lead. “For example, perhaps each crystal could be a qubit in a quantum computer; coupling qubits into arrays is one of the fundamental challenges of quantum technology right now,” said Talapin. 

Portner is also interested in exploring the unusual intermediate state of matter seen during supercrystal growth: “Triple phase coexistence like this is rare enough that it’s intriguing to think about how to take advantage of this chemistry and build new materials.”

The study included scientists with the University of Chicago, Technische Universität Dresden, Northwestern University, Arizona State University, SLAC, Lawrence Berkeley National Laboratory, and the University of California, Berkeley.

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Here’s a link to and a citation for the paper,

Self-assembly of nanocrystals into strongly electronically coupled all-inorganic supercrystals by Igor Coropceanu, Eric M. Janke, Joshua Portner, Danny Haubold, Trung Dac Nguyen, Avishek Das, Christian P. N. Tanner, James K. Utterback, Samuel W. Teitelbaum¸ Margaret H. Hudson, Nivedina A. Sarma, Alex M. Hinkle, Christopher J. Tassone, Alexander Eychmüller, David T. Limmer, Monica Olvera de la Cruz, Naomi S. Ginsberg and Dmitri V. Talapin. Science • 24 Mar 2022 • Vol 375, Issue 6587 • pp. 1422-1426 • DOI: 10.1126/science.abm6753

This paper is behind a paywall.