Category Archives: science

Back to school: Stanford University (California) brings nanoscience to teachers and Ingenium brings STEAM to school

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I have two stories that fit into the ‘back to school’ theme, one from Stanford University and one from Ingenium (Canada’s Museums of Science and Innovation).

Stanford, nanoscience, and middle school teachers

h/t to Google Alert of August 27, 2024 (received via email) for information about a Stanford University programme for middle school teachers. From an August 27, 2024 article in the Stanford Report, Note: Links have been removed,

Crafting holographic chocolate, printing with the power of the sun, and seeing behind the scenes of cutting-edge research at the scale of one-billionth of a meter, educators participating in the Nanoscience Summer Institute for Middle School Teachers (NanoSIMST) got to play the role of students, for a change.

Teachers hailed from the Bay Area and Southern California – one had even come all the way from Arkansas – for the professional development program. NanoSIMST, run by nano@stanford, is designed to connect middle school teachers with activities, skills, and knowledge about science at the scale of molecules and atoms so they can incorporate it into their curriculum. NanoSIMST also prioritizes teachers from Title I schools, which are low-income schools with low-income student populations that receive federal funding to improve academic achievement.

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Debbie Senesky, the site investigator and principal researcher on the nano@stanford project, highlighted the importance of nanoscience at the university. “It’s not just about focusing on research – we also have bigger impacts on entrepreneurs, start-ups, community colleges, and other educators who can use these facilities,” said Senesky, who is also an associate professor of aeronautics and astronautics and of electrical engineering. “We’re helping to train the next generation of people who can be a workforce in the nanotechnology and semiconductor industry.”

The program also supports education and outreach, including through NanoSIMST, which uniquely reaches out to middle school teachers due to the STEM education outcomes that occur at that age. According to a 2009 report by the Lemelson-MIT InvenTeam Initiative, even among teens who were interested in and felt academically prepared in their STEM studies, “nearly two-thirds of teens indicated that they may be discouraged from pursuing a career in science, technology, engineering or mathematics because they do not know anyone who works in these fields (31%) or understand what people in these fields do (28%).”

A teacher from the Oakland Unified School District, Thuon Chen, connected several other teachers from OUSD to attend NanoSIMST as a first-time group. He emphasized that young kids, especially in middle school, have a unique way of approaching new technologies. “Kids have this sense where they’re always pushing things and coming up with completely new uses, so introducing them to a new technology can give them a lot to work with.”

Over the course of four days in the summer, NanoSIMST provides teachers with an understanding of extremely small science and technology: they go through tours of the nano facilities, speak with scientists, perform experiments that can be conducted in the classroom, and learn about careers in nanotechnology and the semiconductor industry.

Tara Hodge, the teacher who flew all the way from Arkansas, was thrilled about bringing what she learned back with her. “I’m not a good virtual learner, honestly. That’s why I came here. And I’m really excited to learn about different hands-on activities. Anything I can get excited about, I know I can get my students excited about.”

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They have provided a video,

One comment regarding the host, Daniella Duran, the director of education and outreach for nano@stanford, she comments about nano being everywhere and, then, says “… everything has a microchip in it.” I wish she’d been a little more careful with the wording. Granted those microchips likely have nanoscale structures.

Ingenium’s STEAM (science, technology, engineering, arts, and mathematics) programmes for teachers across Canada

An August 27, 2024 Ingenium newsletter (received via email) lists STEAM resources being made available for teachers across the country.

There appears to be a temporary copy of the August 27, 2024 Ingenium newsletter here,

STEAM lessons made simple!

Another school year is about to begin, and whether you’re an experienced teacher or leading your first class, Ingenium has what you need to make your STEAM (science, technology, engineering, arts and math) lessons fun! With three museums of science and innovation – the Canada Agriculture and Food Museum, the Canada Aviation and Space Museum and the Canada Science and Technology Museum – under one umbrella, we are uniquely positioned to help your STEAM lessons come to life.

Embark on an exciting adventure with our bilingual virtual field trips and meet the animals in our barns, explore aviation technology, and conduct amazing science experiments.

Or take advantage of our FREE lesson plans, activities and resources to simplify and animate your classroom, all available in English and French. With Ingenium, innovation is at your fingertips!

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Bring the museum to your classroom with a virtual field trip!

Can’t visit in person? Don’t worry, Ingenium will bring the museum to you! All of our virtual field trips are led by engaging guides who will animate each subject with an entertaining and educational approach. Choose from an array of bilingual programs designed for all learners that cover the spectrum of STEAM subjects, including the importance of healthy soil, the genetic considerations of a dairy farm operation, the science of flight, simple machines, climate change and the various states of matter. There is so much to discover with Ingenium. Book your virtual field trip today!

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Here’s a video introduction to Ingenium’s offerings,

To get a look at all the resources, check out this temporary copy of the August 27, 2024 Ingenium newsletter here.

Using a new computer program to ‘paint’ the structure of molecules in the style of a famous Dutch artist

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Figure 2: a) “Neoplastic” diagram of the porphyrin core of the classic nonplanar 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetraphenylporphyrin (CCDC: RONROB), alongside two representations of this same molecule—b) the crystal structure thermal ellipsoid plot and (c) skeletal model.28 This porphyrin shape is primarily saddled and a little ruffled, resulting in S4 symmetry … [downloaded from https://onlinelibrary.wiley.com/doi/10.1002/ange.202403754]

A July 12, 2024 news item on ScienceDaily describes a fascinating computer program developed by scientists at Trinity College Dublin,

Scientists from Trinity College Dublin have created a computer program that “paints” the structure of molecules in the style of famous Dutch artist, Piet Mondrian, whose beautiful artworks will be instantly recognizable to many.

Mondrian’s style, whereby he used blocks of primary colors separated by lines of various widths on a white background, has been extensively copied or used as an inspiration in modern culture. But his deceptively simple artworks have also fascinated scientists for decades, finding niche applications in mathematics and statistics.

And now, researchers from the School of Chemistry are opening eyes and minds to the beauty of molecular structure, as well as posing new questions about the form and function of the molecules themselves.

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A July 15, 2024 Trinity College Dublin press release (also on EurekAlert but published July 12, 2024), which originated the news item, provides more details about the work,

Their computer program, which can be accessed at http://www.sengegroup.eu/nsd, produces a Mondrianesque plot of any molecule. It does so by following an artistic algorithm that marries the laws of chemistry that describe the 3D structure of a molecule based on its components with the 2D style of one of the most influential painters of the Modern era.

For the scientist, it helps to rapidly assess and demonstrate molecular symmetry, allowing for deeper insights than would emerge from traditional representations. And for the artist, it provides a visually pleasing image of contrasting interpretations of symmetry, hopefully providing inspiration for the incorporation of scientific ideas into work. 

Mathias O Senge, Professor of Organic Chemistry in Trinity and Hans Fischer Senior Fellow at the Institute for Advanced Study of TU Munich [Technische Universität München or Technical University of Munich] is the senior author of a just-published article in the leading international journal, Angewandte Chemie, in which this creation is shared with the world. He said:

“For some years we have been working on this project, initially for fun, to output the structure of a molecule in an artistically pleasing manner as a painting in the style of Mondrian. The ‘paintings’ obtained are unique for each molecule and juxtapose what Mondrian and others aimed to do with the De Stijl artistic movement.

“Symmetry and shape are essential aspects of molecular structure and how we interpret molecules and their properties, but very often relationships between chemical structure and derived values are obscured. Taking our inspiration from Mondrian’s Compositions, we have depicted the symmetry information encoded within 3D data as blocks of colour, to show clearly how chemical arguments may contribute to symmetry.” 

Christopher Kingsbury, postdoctoral researcher in TBSI, who conceived the project, is first author of the journal article. He said: “In chemistry, it is useful to have a universal way of displaying molecular structure, so as to help ‘blueprint’ how a molecule is likely to behave in different environments and how it may react and change shape when in the presence of other molecules. But a certain amount of nuance is inevitably lost.

“This concept of increasing abstraction by removing minor details and trying to present a general form is mimicked by the early work of Mondrian and in some senses this is what scientists intuitively do when reducing complex phenomena to a ‘simpler truth’. Thanks to our new approach very complex science is fed through an artistic lens, which might make it more accessible to a wider range of people.”  

In recent years Professor Senge and his team have greatly enhanced our understanding of porphyrins, a unique class of intensely coloured pigments – also known as the “colours of life”. In one piece of work they created a suite of new biological sensors by chemically re-engineering these pigments to act like tiny Venus flytraps and grab specific molecules, such as pollutants. And now the new direction, in which science and art collide, may further develop our understanding of how porphyrins work.

“Great art gives us a new perspective on the world,” added Prof. Senge. “As a pastiche, this art may allow us to look at familiar molecules, such as porphyrins, in a new light, and help us to better understand how their shape and properties are intertwined. More generally, we believe that contemporary initiatives in ‘Art and Science’ require a transformative break of discipline boundaries and merger to ‘ArtScience’. There is a subtle interplay between science and art and mixing of both aspects in our respective fields of endeavour and this should be a focus for future developments in both areas.”

Here’s a link to and a citation for the paper,

Molecular Symmetry and Art: Visualizing the Near-Symmetry of Molecules in Piet Mondrian’s De Stijl by Dr. Christopher J. Kingsbury, Prof. Dr. Mathias O. Senge. Angewandte Chemie DOI: https://doi.org/10.1002/ange.202403754 Volume 136, Issue 25 June 17, 2024 e202403754 First published: 15 April 2024

This paper is open access.

‘Six’ degrees of Kevin Bacon gene

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It must have been a lighthearted moment that led to this new gene being called “degrees of Kevin Bacon” (dokb). Here’s more about the gene and the research from a May 24, 2024 University of Toronto (UofT) news release by Chris Sasaki, Note: Links have been removed,

A team of researchers from the University of Toronto has identified a gene in fruit flies that regulates the types of connections between flies within their “social network.”

The researchers studied groups of two distinct strains of Drosophila melanogaster fruit flies and found that one strain showed different types or patterns of connections within their networks than the other strain.

The connectivity-associated gene in the first strain was then isolated. When it was swapped with the other strain, the flies exhibited the connectivity of the first strain.

The researchers named the gene “degrees of Kevin Bacon” (dokb), for the prolific Hollywood star of such films as Footloose and Apollo 13. Bacon’s wide-ranging connections to other actors is the subject of the parlour game called “The Six Degrees of Kevin Bacon,” which plays on the popular idea that any two people on Earth can be linked through six or fewer mutual acquaintances.

“There’s been a lot of research around whether social network structure is inherited, but that question has been poorly understood,” says Rebecca Rooke, a post-doctoral fellow in the department of ecology and evolutionary biology in the Faculty of Arts & Science and lead author of the paper, published in Nature Communications. “But what we’ve now done is find the gene and proven there is a genetic component.”

The work was carried out as part of Rooke’s PhD thesis in Professor Joel Levine’s laboratory at U of T Mississauga before he moved to the department of ecology and evolutionary biology, where he is currently chair.

“This gives us a genetic perspective on the structure of a social group,” says Levine. “This is amazing because it says something important about the structure of social interactions in general and about the species-specific structure of social networks.

“It’s exciting to be thinking about the relationship between genetics and the group in this way. It may be the first time we’ve been able to do this.”

The researchers measured the type of connection by observing and recording on video groups of a dozen male flies placed in a container. Using software previously developed by Levine and post-doctoral researcher Jon Schneider, the team tracked the distance between flies, their relative orientation and the time they spent in close proximity. Using these criteria as measures of interaction, the researchers calculated the type of connection or “betweenness centrality” of each group.

Rooke, Levine and their colleagues point out that individual organisms with high betweenness centrality within a social network can act as “gatekeepers” who play an important role in facilitating interactions within their group.

Gatekeepers can influence factors like the distribution of food or the spread of disease. They also play a role in maintaining cohesion, enhancing communication and ensuring better overall health of their group.

In humans, betweenness centrality can even affect the spread of behaviours such as smoking, drug use and divorce.

At the same time, the researchers point out that social networks are unbiased and favour neither “good” nor “bad” outcomes. For example, high betweenness centrality in a network of scientists can increase potential collaborators; on the other hand, high betweenness centrality in another group can lead to the spread of a disease like COVID-19.

“You don’t get a good or a bad outcome from the structure of a network,” explains Levine. “The structure of a network could carry happiness or a disease.”

Rooke says an important next step will be to identify the overall molecular pathway that the gene and its protein are involved in “to try to understand what the protein is doing and what pathways it’s involved in – the answers to those questions will really give us a lot of insight into how these networks work.”

And while the dokb gene has only been found in flies so far, Rooke, Levine and their colleagues anticipate that similar molecular pathways between genes and social networks will be found in other species.

“For example, there’s a subset of cells in the human brain whose function relates to social experience – what in the popular press might be called the ‘social brain,’” says Levine.

“Getting from the fly to the human brain – that’s another line of research. But it almost has to be true that the things that we’re observing in insects will be found in a more nuanced, more dispersed way in the mammalian brain.”

Katie Hunt wrote a May 2, 2024 article, for CNN, about the research, shortly after the paper was published, which included some intriguing personal details and a good explanation of why fruit flies are used in genetic research, Note: Links have been removed,

Many species of animals form social groups and behave collectively: An elephant herd follows its matriarch, flocking birds fly in unison, humans gather at concert events. Even humble fruit fliesorganize themselves into regularly spaced clusters, researchers have found.

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And now, scientists believe there is evidence that how central you are to your social network, a concept they call “high betweenness centrality,” could have a genetic basis. New research published Tuesday in the journal Nature Communications has identified a gene responsible for regulating the structure of social networks in fruit flies.

The study’s authors named the gene in question “degrees of Kevin Bacon,” or dokb, after a game that requires players to link celebrities to actor Bacon in as few steps as possible via the movies they have in common.

Inspired by “six degrees of separation,” the theory that nobody is more than six relationships away from any other person in the world, the game became a viral phenomenon three decades ago.

Senior author Joel Levine, a professor of biology at the University of Toronto who went to high school with Bacon in Philadelphia [emphases mine], said the actor was a good human example of “high betweenness centrality.”

Aware of Levine’s link with Bacon, study lead author Rebecca Rooke, a postdoctoral fellow of biology at the University of Toronto Mississauga, suggested the gene’s name.

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Levine said that the “degrees of Kevin Bacon” gene was specific to fruit flies’ central nervous systems, but he thought similar genetic pathways would exist in other animals, including humans. The study opened up new opportunities for exploring the molecular evolution of social networks and collective behavior in other animals.

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Drosophila melanogaster, best known for hovering around fruit bowls, has been a model organism to explore genetics for more than 100 years. The insects breed quickly and are easy to keep.

While flies are very different from humans, the creatures have long been central to biological and genetic discovery.

“Fruit flies are useful because of the power of manipulation. We can investigate things experimentally in Drosophila that we can only examine indirectly in most organisms,” Moore said.

The tiny creatures share nearly 60% of our genes, including those responsible for Alzheimer’s, Parkinson’s, cancer and heart disease. Research involving fruit flies has previously shed light on the mechanisms of inheritance, circadian rhythms and mutation-causing X-rays.

Here’s a link to and a citation for the paper,

The gene “degrees of kevin bacon” (dokb) regulates a social network behaviour in Drosophila melanogaster by Rebecca Rooke, Joshua J. Krupp, Amara Rasool, Mireille Golemiec, Megan Stewart, Jonathan Schneider & Joel D. Levine. Nature Communications volume 15, Article number: 3339 (2024)
DOI: https://doi.org/10.1038/s41467-024-47499-8 Published online: 30 April 2024

This paper is open access.

h/t Rae Hodge’s May 30, 2024 article on Salon.com. Otherwise, I would have missed this ‘science meets pop culture’ story.

11th century Arab-Muslim optical scientist laid groundwork for modern-day physics

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An April 15, 2024 news item on phys.org announces research into how an Arab scientist’s studies into optics established the basis for modern day physics,

Scientists from the University of Sharjah [United Arab Emirates] and the Warburg Institute [University of London, UK] are poring over the writings of an 11th-century Arab-Muslim polymath to demonstrate their impact on the development of optical sciences and how they have fundamentally transformed the history of physics from the Middle Ages up to modern times in Europe.

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Caption: Ibn al-Haytham (“Alhasen”) on the left pedestal of reason [while Galileo is on the right pedestal of the senses] as shown on the frontispiece of the Selenographia (Science of the Moon; 1647) of Johannes HeveliusIbn al-Haytham (“Alhasen”) on the left pedestal of reason [while Galileo is on the right pedestal of the senses] as shown on the frontispiece of the Selenographia (Science of the Moon; 1647) of Johannes Hevelius Credit: Public domain provided by the author

A May 6, 2024 University of Sharjah press release on EurekAlert, which originated the news item, delves further into the topic, Note 1: Why there’s such a large discrepancy in the publication dates for the press release is a mystery to me; Note 2: Links have been removed,

Their research focuses on the legacy of al-Ḥasan Ibn al-Haytham known in Latin as “Alhazen” and particularly his most influential work titled Book of Optics, reputed in Arabic as Kitab al-Manazir and first circulated in Europe via its Latin translation dubbed ‘Perspectiva’. Ibn al-Haytham was born in the southern Iraqi city of Basra in 965 during the Abbasid Caliphate.

The divisions IV-V of this authoritative book have been recently translated into English from Arabic and published by the Warburg Institute under the title “The Optics of Ibn al-Haytham, Books IV–V: On Reflection and Images Seen by Reflection”. Having already rendered divisions I-III into English, the Warburg Institute is bringing together a wide-ranging network of scientists “for a collaborative humanities-science investigation of [Ibn] al-Haytham and the questions his work provokes.“

The role of Alhazen [Ibn al-Haytham] in these processes is simultaneously well-known, but limited; only half of his scientific works have English translation and a quarter are not yet edited.”

Introducing the new translation, the Warburg Institute describes Ibn al-Haytham as “perhaps the greatest mathematician and physicist of the medieval Arabic/Islamic world. His reputation is based not only on the vast amount of material he was able to process, but also on his rigorous scientific methodology.

“He (Ibn al-Haytham) deals with both the mathematics of rays of light and the physical aspects of the eye in seven comprehensive books. His reinstatement of the entire science of optics sets the scene for the whole of the subsequent development of the subject … influencing figures such as William of Ockham, [Johannes] Kepler, [René] Descartes, and Christaan Huygens.”

Professor Nader El-Bizri of Sharjah University’s College of Arts, Humanities, and Social Sciences has just published an academic review of the Warburg Institute’s translation of Ibn al-Haytham. The article, printed in the International Journal of the Classical Tradition, highlights the strong influence the Arab-Muslim optical scientist has exerted over the ages up to the present day.

Ibn al-Haytham’s Book of Optics, Prof. El-Bizri writes, “constituted a monumental foundational opus in the history of science and the visual arts from the Middle Ages to the early modern period in the European milieu and the Islamicate context … The reception of Ibn al-Haytham’s Optics in the European milieu took place from the High Middle Ages via Gerard of Cremona’s Toledo circle in terms of its Latinate translations, and subsequent influence on Franciscan, Dominican, and Jesuit opticians across Europe.“

It influenced François d’Aguilon’s Opticorum libri sex within the Antwerp Jesuit mathematical school and had a direct impact on Johannes Hevelius’s Selenographia. The Optics was also consulted by Girard Desargues, René Descartes, Johannes Kepler and Christaan Huygens.”

Prof. El-Bizri works closely with the Warburg Institute assisting its attempts to reintroduce Ibn al-Haytham to the west. “A remarkable thinker, not only did Ibn al-Haytham revolutionize optical thought by mathematising its study, [but] his thinking also went on to have similar revolutionary effects in medieval Europe.”

The Warburg Institute is investing in rendering the writings of Ibn al-Haytham on optics into English, which Prof. El-Bizri describes as “voluminous”. “Ibn al-Haytham’s Book of Optics indicates with evidence the impact of Arabic sciences and philosophy on the history of science and the architectural and visual arts in Europe, as well as demonstrating how science and the arts influence each other in the manner the studies of optics in their mathematized physics inspired the invention of projective geometric constructions of perspective as a novel Renaissance method of painting and architectural design.”

Prof. El-Bizri adds “The impact of this book is fundamental not only in the history of science from the High Middle Ages till the early-modern period in Europe, but it was also foundational for architecture and the visual arts in the Italian Renaissance and up till the late Baroque era. Moreover, it has further significance in modern conceptions of the mathematization of physics, the reliance on experimentation in science, and the philosophical analysis of perception.”

Asked about the importance of translating Ibn al-Haytham into English despite the lapse of nearly 1000 years, Prof. El-Bizri says the Arab-Muslim scientist’s theories and methodologies, specifically those dealing with optics are still considered “seminal” in the literature. Ibn al-Haytham has had a “foundational impact on the history of science and the arts in Europe.”

The influence of Ibn al-Haytham’s writings in the European milieu, according to Prof. El-Bizri, cannot be overlooked. The Arab-Muslim scientist had “a notable effect on Biagio Pelacani da Parma’s Questiones super perspectiva communi, Leon Battista Alberti’s De pictura, Lorenzo Ghiberti’s Commentarii, culminating in the first printed Latin version in the publication of Friedrich Risner’s Opticae thesaurus in the sixteenth century.“

Then, in the seventeenth century, it influenced François d’Aguilon’s Opticorum libri sex within the Antwerp Jesuit mathematical school and had a direct impact on Johannes Hevelius’s Selenographia.”.

In the Book of Optics, notes Prof. El-Bizri, Ibn al-Haytham establishes an “inventive and precise scientific experimental method (al-iʿtibār al-muḥarrar) with its controlled verificative repeated testing, as framed by isomorphic compositions between physics and mathematics.”

He adds that Ibn al-Haytham in his Optics “aims at elucidating the nature of visual perception through studies on the anatomy and physiology of the eyes, the optic nerves and the frontal part of the brain, along with cognitive psychology and the analysis of psychosomatic ocular motor kinaesthetic acts”

Here’s a link to and a citation for the paper, Note: This is one of the more unusual citation I have hrere,

The Optics of Ibn al-Haytham, Books IV–V: On Reflection and Image by N. El-Bizri. Seen by Reflection, translated from the Arabic by Abdelhamid I. Sabra and prepared for publication by Jan P. Hogendijk (Warburg Institute Studies and Texts, 8), London: University of London Press in association with the Warburg Institute, 2023, pp. xiv+343, ISBN 978-1908590589, £90. Int class trad 31, 116–119 (2024). https://doi.org/10.1007/s12138-024-00654-4 Published: 20 February 2024 Issue Date: March 2024

This paper is behind a paywall.

I was a little curious about the Warburg Institute and found out more on their About Us webpage,

The Warburg Institute is one of the world’s leading centres for the study of art and culture. Its collections, courses and programmes are dedicated to the study of global cultural history and the role of images in society. Founded in Hamburg at the turn of the twentieth century by historian Aby Warburg (1866-1929), the Institute was established to trace the roots of the Renaissance in ancient civilisations and ended up changing the way we see the world around us.

The Warburg Institute owes its mission—and its very existence—to the open movement of people, collections and ideas. Sent into exile when the Nazis came to power, the Institute was transferred to England in 1933 and became part of the University of London in 1944. It has served, during a turbulent century, as a creative crucible for scholars, curators, artists and all those whose work sits outside traditional academic structures.

The Warburg’s unique Library, Archive and Photographic Collection form a holistic, associative engine for exploring the histories of the arts and sciences—linking the textual and the visual, the intellectual and the social, the scientific and the magical. Following an extensive renovation of the Institute’s building in Bloomsbury, new spaces for exhibitions and events have restored the Institute’s original emphasis on discovery, display and debate and are bringing its holdings and programmes to new audiences.

Building on Aby Warburg’s belief that the memory of the past activates the present, the Warburg examines the movement of culture across barriers – of time, space and discipline -to inspire, inform and connect.

There you have it.

Programmable living materials made with 3D printing methods and synthetic biology

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There’s more than one ‘living’ material story here on this blog; it’s the plant cells that make this latest story different from the others. From a May 1, 2024 news item on phys.org, Note: A link has been removed,

Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid “engineered living materials” are made by embedding cells in an inanimate matrix that’s formed in a desired shape. Now, researchers report in ACS Central Science that they have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.

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Caption: After 24 days, the colors produced by plant cells in two different bioinks printed in this leaf-shaped engineered living material are clearly visible. Credit: Adapted from ACS Central Science 2024, DOI: 10.1021/acscentsci.4c00338

A May 1, 2024 American Chemical Society (ACS) news release (also on EurekAlert), which originated the news item, explains what makes this living material different,

Recently, researchers have been developing engineered living materials, primarily relying on bacterial and fungal cells as the live component. But the unique features of plant cells have stirred enthusiasm for their use in engineered plant living materials (EPLMs). However, the plant cell-based materials created to date have had fairly simple structures and limited functionality. Ziyi Yu, Zhengao Di and colleagues wanted to change that by making intricately shaped EPLMs containing genetically engineered plant cells with customizable behaviors and capabilities.

The researchers mixed tobacco plant cells with gelatin and hydrogel microparticles that contained Agrobacterium tumefaciens, a bacterium commonly used to transfer DNA segments into plant genomes. This bioink mixture was then 3D printed on a flat plate or inside a container filled with another gel to form shapes such as grids, snowflakes, leaves and spirals. Next, the hydrogel in the printed materials was cured with blue light, hardening the structures. During the ensuing 48 hours, the bacteria in the EPLMs transferred DNA to the growing tobacco cells. The materials were then washed with antibiotics to kill the bacteria. In the following weeks, as the plant cells grew and replicated in the EPLMs, they began producing proteins dictated by the transferred DNA.

In this proof-of-concept study, the transferred DNA enabled the tobacco plant cells to produce green fluorescent proteins or betalains — red or yellow plant pigments that are valued as natural colorants and dietary supplements. By printing a leaf-shaped EPLM with two different bioinks — one that created red pigment along the veins and the other a yellow pigment in the rest of the leaf — the researchers showed that their technique could produce complex, spatially controlled and multifunctional structures. Such EPLMs, which combine the traits of living organisms with the stability and durability of non-living substances, could find use as cellular factories to churn out plant metabolites or pharmaceutical proteins, or even in sustainable construction applications, according to the researchers.

The authors acknowledge funding from National Key Research and Development Program of China, the National Natural Science Foundation of China, the Natural Science Foundation of Jiangsu Province, and the State Key Laboratory of Materials-Oriented Chemical Engineering.

Here’s a link to and a citation for the paper,

Advancing Engineered Plant Living Materials through Tobacco BY-2 Cell Growth and Transfection within Tailored Granular Hydrogel Scaffolds by Yujie Wang, Zhengao Di, Minglang Qin, Shenming Qu, Wenbo Zhong, Lingfeng Yuan, Jing Zhang, Julian M. Hibberd, and Ziyi Yu. ACS Cent. Sci. 2024, 10, 5, 1094–1104 DOI: https://doi.org/10.1021/acscentsci.4c00338 Publication Date:May 1, 2024 Copyright © 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.

This paper is open access.

I think the last three years in particular have seen an upsurge of living materials stories (on this blog, at least). This one is a favourite of mine,

If you’re curious to see more, I suggest using the search term ‘living materials’.

Books can be toxic (literally)

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I do love word play although I am pushing it a bit with ‘book’, ‘literature’, and ‘literal’.

These poison books each contain heavy metals used to create striking colours [in] the 1800s. Source: Museums Victoria Photo: Rob French [downloaded from https://museumsvictoria.com.au/article/if-books-could-kill-poison-heavy-metal-and-literature/]

Mark Lorch’s, Professor of Science Communication and Chemistry at the University of Hull (UK), April 29, 2024 essay on The Conversation (h/t April 30, 2024 news item on phys.org) provides an interesting account of the dangers associated with literature, Note: Links have been removed,

In our modern society, we rarely consider books to be dangerous items. However, certain books contain elements so hazardous that they require scrutiny before being placed on the shelves of public libraries, bookstores or even private homes.

The Poisonous Book Project [also known as, Poison Book Project], a collaborative research project between Winterthur Museum, Garden & Library and the University of Delaware, is dedicated to cataloguing such books. Their concern is not with the content written on the pages, but with the physical components of the books themselves — specifically, the colours of the covers.

The project recently influenced the decision to remove two books from the French national library. The reason? Their vibrant green cloth covers raised suspicions of containing arsenic.

This concern is rooted in historical practices in bookbinding. During the 19th century, as books began to be mass produced, bookbinders transitioned from using expensive leather covers to more affordable cloth items. To attract readers, these cloth covers were often dyed in bright, eye-catching colours.

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One popular pigment was Scheele’s green, named after Carl Wilhelm Scheele, a German-Swedish chemist who in 1775 discovered that a vivid green pigment could be produced from copper and arsenic. This dye was not only cheap to make, it was also more vibrant than the copper carbonate greens that had been used for over a century.

Scheele green eventually fell out of favour because it had a tendency to fade to black when it reacted with sulphur-based pollutants released from coal. But new dyes based on Scheele’s discovery, such as emerald and Paris green, proved to be much more durable. …

These pigments, however, had a significant drawback: they degraded easily, releasing poisonous and carcinogenic arsenic. The frequent reports of green candles poisoning children at Christmas parties, factory workers tasked with applying paint to ornaments convulsing and vomiting green water and warnings of poisonous ball dresses raised serious concerns about the safety of these green dyes.

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Green isn’t the only colour to worry about, however. Red is also of concern. The brilliant red pigment vermilion was formed from the mineral cinnabar, also known as mercury sulfide. This was a popular source of red paint dating back thousands of years. There is even evidence that neolithic artists suffered from mercury poisoning. Vermilion red sometimes appears on the marbled patterns on the inside of book covers.

Yellow has also caught the eye of the poisonous book project. In this case, the culprit is lead chromate. The bright yellow of lead chromate was a favourite with painters, not least Vincent van Gogh, who used it extensively in his most famous series of paintings: Sunflowers. For the Victorian-era bookbinders, lead chromate allowed them to create a range of colours from greens (achieved by mixing chrome yellow with Prussian blue) to yellows, oranges and browns.

…

So what should you do if you come across a green cloth book from the 19th century? First, don’t be overly concerned. You would probably have to eat the entire book before you’d suffer from severe arsenic poisoning. However, casual exposure to copper acetoarsenite, the compound in the green pigment, can irritate the eyes, nose and throat.

It is more of a concern for folks who may regularly handle these books where frequent contact could result in more serious symptoms. Therefore, anyone who suspects they might be handling a Victorian-era book with an emerald green binding is advised to wear gloves and avoid touching their face. Then clean all surfaces afterwards.

…

If you have a bit of time, Lorch’s April 29, 2024 essay is fascinating. If you have more time, there’s the undated “If books could kill: poison, heavy metal and literature” article on the Museums Victoria (Australia) website,

Books are not usually thought of as hazardous objects, but you will want to be careful with these ones from the Melbourne Museum’s Rare Book Collection.

Poisonous heavy metals permeate their very fabric, and the last 150-odd years has done nothing to lessen their toxicity.

How did it happen though?

This is not some dastardly Name of the Rose-esque plot [a reference to Umberto Eco and his 1986 novel, The Name of the Rose] but rather a combination of fashion, vanity, and workers’ rights (or lack thereof) in the years following the Industrial Revolution.

And it has left a dangerous legacy for modern-day museums.

…

Lastly, you can find the Poison Book Project here.

A biochemical means of protecting passwords and anti-counterfeiting solution for art and other precious goods

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I guess you could say my passwords are as precious to me as a piece.of art is to some people.

DNA can be used to confirm the authenticity of valuable art prints. (AI-​generated image: ETH Zurich)

An April 8, 2024 ETH Zurich press release (also on EurekAlert) by Fabio Bergamin features an approach that could make passwords secure from quantum computers, Note: A link has been removed,

Security experts fear Q-​Day, the day when quantum computers become so powerful that they can crack today’s passwords. Some experts estimate that this day will come within the next ten years. Password checks are based on cryptographic one-​way functions, which calculate an output value from an input value. This makes it possible to check the validity of a password without transmitting the password itself: the one-​way function converts the password into an output value that can then be used to check its validity in, say, online banking. What makes one-​way functions special is that it’s impossible to use their output value to deduce the input value – in other words, the password. At least not with today’s resources. However, future quantum computers could make this kind of inverse calculation easier.

Researchers at ETH Zurich have now presented a cryptographic one-​way function that works differently from today’s and will also be secure in the future. Rather than processing the data using arithmetic operations, it is stored as a sequence of nucleotides – the chemical building blocks of DNA.

Based on true randomness

“Our system is based on true randomness. The input and output values are physically linked, and it’s only possible to get from the input value to the output value, not the other way round,” explains Robert Grass, a professor in the Department of Chemistry and Applied Biosciences. “Since it’s a physical system and not a digital one, it can’t be decoded by an algorithm, not even by one that runs on a quantum computer,” adds Anne Lüscher, a doctoral student in Grass’s group. She is the lead author of the paper, which was published in the journal Nature Communications.

The researchers’ new system can serve as a counterfeit-​proof way of certifying the authenticity of valuable objects such as works of art. The technology could also be used to trace raw materials and industrial products.

How it works

The new biochemical one-​way function is based on a pool of one hundred million different DNA molecules. Each of the molecules contains two segments featuring a random sequence of nucleotides: one segment for the input value and one for the output value. There are several hundred identical copies of each of these DNA molecules in the pool, and the pool can also be divided into several pools; these are identical because they contain the same random DNA molecules. The pools can be located in different places, or they can be built into objects.

Anyone in possession of this DNA pool holds the security system’s lock. The polymerase chain reaction (PCR) can be used to test a key, or input value, which takes the form of a short sequence of nucleotides. During the PCR, this key searches the pool of hundreds of millions of DNA molecules for the molecule with the matching input value, and the PCR then amplifies the output value located on the same molecule. DNA sequencing is used to make the output value readable.

At first glance, the principle seems complicated. “However, producing DNA molecules with built-​in randomness is cheap and easy,” Grass says. The production costs for a DNA pool that can be divided up in this way are less than 1 Swiss franc. Using DNA sequencing to read out the output value is more time-​consuming and expensive, but many biology laboratories already possess the necessary equipment.

Securing valuable goods and supply chains

ETH Zurich has applied for a patent on this new technology. The researchers now want to optimise and refine it to bring it to market. Because using the method calls for specialised laboratory infrastructure, the scientists think the most likely application for this form of password verification is currently for highly sensitive goods or for access to buildings with restricted access. This technology won’t be an option for the broader public to check passwords until DNA sequencing in particular becomes easier.

A little more thought has already gone into the idea of using the technology for the forgery-​proof certification of works of art. For instance, if there are ten copies of a picture, the artist can mark them all with the DNA pool – perhaps by mixing the DNA into the paint, spraying it onto the picture or applying it to a specific spot.

If several owners later wish to have the authenticity of these artworks confirmed, they can get together, agree on a key (i.e. an input value) and carry out the DNA test. All the copies for which the test produces the same output value will have been proven genuine. The new technology could also be used to link crypto-​assets such as NFTs, which exist only in the digital world, to an object and thus to the physical world.

Furthermore, it would support counterfeit-​proof tracking along supply chains of industrial goods or raw materials. “The aviation industry, for example, has to be able to provide complete proof that it uses only original components. Our technology can guarantee traceability,” Grass says. In addition, the method could be used to label the authenticity of original medicines or cosmetics.

Here’s a link to and a citation for the paper,

Chemical unclonable functions based on operable random DNA pools by Anne M. Luescher, Andreas L. Gimpel, Wendelin J. Stark, Reinhard Heckel & Robert N. Grass. Nature Communications volume 15, Article number: 2955 (2024) DOI: https://doi.org/10.1038/s41467-024-47187-7 Published: 05 April 2024

This paper is open access.

Could this discovery end global amphibian pandemic?

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Caption: Panamanian golden frog is nearing extinction. Credit: Brian Gratwicke/U.S. Fish & Wildlife Service

An April 3, 2024 University of California at Riverside (also on EurekAlert) by Jules Bernstein describes the possibility of using a virus to infect a fungus that kills frogs worldwide, Note: A link has been removed,

A fungus devastating frogs and toads on nearly every continent may have an Achilles heel. Scientists have discovered a virus that infects the fungus, and that could be engineered to save the amphibians.

The fungus, Batrachochytrium dendrobatidis or Bd, ravages the skin of frogs and toads, and eventually causes heart failure. To date it has contributed to the decline of over 500 amphibian species, and 90 possible extinctions including yellow-legged mountain frogs in the Sierras and the Panamanian golden frog. 

A new paper in the journal Current Biology documents the discovery of a virus that infects Bd, and which could be engineered to control the fungal disease.

The UC Riverside researchers who found the virus are excited about the implications of their discovery. In addition to helping them learn about how fungal pathogens rise and spread, it offers the hope of ending what they call a global amphibian pandemic. 

“Frogs control bad insects, crop pests, and mosquitoes. If their populations all over the world collapse, it could be devastating,” said UCR microbiology doctoral student and paper author Mark Yacoub. 

“They’re also the canary in the coal mine of climate change. As temperatures get warmer, UV light gets stronger, and water quality gets worse, frogs respond to that. If they get wiped out, we lose an important environmental signal,” Yacoub said. 

Bd was not prevalent before the late 1990s, but then, “all of a sudden frogs started dying,” Yacoub said.

When they found the Bd-infecting virus, Yacoub and UCR microbiology professor Jason Stajich had been working on the population genetics of Bd, hoping to gain a better understanding about where it came from and how it is mutating. 

“We wanted to see how different strains of fungus differ in places like Africa, Brazil, and the U.S., just like people study different strains of COVID-19,” Stajich said. To do this, the researchers used DNA sequencing technology. As they examined the data, they noticed some sequences that did not match the DNA of the fungus. 

“We realized these extra sequences, when put together, had the hallmarks of a viral genome,” Stajich said. 

Previously, researchers have looked for Bd viruses but did not find them. The fungus itself is hard to study because complex procedures are required to keep it alive in a laboratory. 

“It is also a hard fungus to keep track of because they have a life stage where they’re motile, they have a flagellus, which resembles a sperm tail, and they swim around,” Stajich said. 

Additionally, the virus that infects Bd was hard to find because most known viruses that infect fungi, called mycoviruses, are RNA viruses. However, this virus is a single-stranded DNA virus. By studying the DNA, the researchers could see the virus stuck in the genome of the fungus. 

It appears that only some strains of the fungus have the virus in their genome. But the infected ones seem to behave differently than the ones that don’t. “When these strains possess the virus they produce fewer spores, so it spreads more slowly. But they also might become more virulent, killing frogs faster,” Stajich said. 

Right now, the virus is essentially trapped inside the fungal genome. The researchers would eventually like to clone the virus and see if a manually infected strain of Bd also produces fewer spores.

“Because some strains of the fungus are infected and some are not, this underscores the importance of studying multiple strains of a fungal species,” Yacoub said. 

Moving forward, the researchers are looking for insights into the ways that the virus operates. “We don’t know how the virus infects the fungus, how it gets into the cells,” Yacoub said. “If we’re going to engineer the virus to help amphibians, we need answers to questions like these.”

In some places, it appears there are a few amphibian species acquiring resistance to Bd. “Like with COVID, there is a slow buildup of immunity. We are hoping to assist nature in taking its course,” Yacoub said. 

Here’s a link to and a citation for the paper,

An endogenous DNA virus in an amphibian-killing fungus associated with pathogen genotype and virulence by Rebecca A. Clemons, Mark N. Yacoub, Evelyn Faust, L. Felipe Toledo, Thomas S. Jenkinson, Tamilie Carvalho, D. Rabern Simmons, Erik Kalinka, Lillian K. Fritz-Laylin, Timothy Y. James, Jason E. Stajich. Current Biology Volume 34, ISSUE 7, P1469-1478.e6, April 08, 2024 DOI: https://doi.org/10.1016/j.cub.2024.02.062 Published online: March 14, 2024

This paper is open access.

Happy Canada Day! Breakdancing at the 2024 Paris Summer Olympics: physics in action + heat, mosquitoes, and sports

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Happy July 1, 2024, also known as, Canada Day!

Onto breakdancing (or breaking), which for the first time will be an official event at the 2024 Paris Summer Olympics. Amy Pope, principal lecturer, physics and astronomy, Clemson University (South Carolina, US), has written a June 12, 2024 essay for The Conversation that describes breakdancing as physics in action, (h/t June 13, 2024 news item in phys.org), Note: Links have been removed,

Two athletes square off for an intense dance battle. The DJ starts spinning tunes, and the athletes begin twisting, spinning and seemingly defying gravity, respectfully watching each other and taking turns showing off their skill.

The athletes converse through their movements, speaking through a dance that celebrates both athleticism and creativity. While the athletes probably aren’t consciously thinking about the physics behind their movements, these complex and mesmerizing dances demonstrate a variety of different scientific principles.

Breaking, also known as breakdancing, originated in the late 1970s in the New York City borough of the Bronx. Debuting as an Olympic sport in the 2024 Summer Olympics, breaking will showcase its dynamic moves on a global stage. This urban dance style combines hip-hop culture, acrobatic moves and expressive footwork.

Since its inception, breaking has evolved into a competitive art form. An MC narrates the movements, while a DJ mixes songs to create a dynamic atmosphere. The Olympics will feature two events: one for men, called B-boys, and one for women, called B-girls. In these events, athletes will face off in dance battles.

… Success in this sport requires combining dance moves from three basic categories: top rock, down rock and freeze.

…

And now for the physics of it all, from Pope’s June 12, 2024 essay, Note: Links have been removed,

…

Top rock moves [emphasis mine] are performed while standing up, focusing on fancy footwork and hand movements. These movements are reminiscent of hip-hop dancing.

Top rock moves rely on having lots of friction between an athlete’s shoes and the floor. Friction is the force [emphasis miine] that resists when you slide something across a surface.

This friction allows the athlete to take very quick steps and to stop abruptly. The dancers must intuitively understand inertia, or the fact that their bodies will continue in the direction they’re moving unless they are acted upon by an external force. To stop abruptly, athletes need to engage their muscles, getting their shoes to grip the ground to stop themselves from continuing forward.

…

Down rock moves [emphasis mine] are performed while on the floor. Athletes may spin in circles with their head, back, elbows or shoulders touching the ground and their feet in the air. B-boys and B-girls rely heavily on an internal knowledge of physics to complete these moves.

Consider the physics of a backspin. A backspin occurs when the athlete is on their back with their feet lifted in the air, rotating around a specific area of their back.

Sitting on the floor, the athlete’s left foot stays in contact with the floor while they spread their right leg wide, gathering linear momentum [emphasis mine] as they sweep their right leg toward their left foot in a wide arc. Then, they release their left leg from contact with the ground and roll onto their back.

Now that only their back is in contact with the ground, the linear momentum from their leg turns into angular momentum [emphasis mine], which rotates the athlete around an axis that extends upward from their back’s contact point with the ground. This move turns magical when they bring their legs and arms inward, toward the axis of rotation. This principal is called conservation of angular momentum.

When an athlete brings their mass in more closely to the axis of rotation, the athlete’s rotations speed up. Extending their legs and arms once again and moving their mass away from the axis of rotation will cause the competitor to slow their rotation speed down. Once they slow down, they can transition to another move.

…

Freeze [emphasis mine] occurs when athletes come to a stop in a funky pose, often occurring in time to the music and in an upside-down position. To freeze effectively, the athlete must have full control over their center of mass, placing it right above the point of their body that is in contact with the floor. The center of mass is the average position of all the parts of an athlete, weighted according to their masses. The “balance point” where the entire mass of the athlete seems to be concentrated is the center of mass.

Athletes are most stable when their center of mass is as close to the ground as possible. You will see many competitors freeze with arms bent in an effort to lower their center of mass. This lowered center of mass reduces their distance from the floor and minimizes the tendency of their body to rock to one side or the other due to torque.

Torque is a twisting force [emphasis mine], like the force used to turn a wrench. The torque depends on two things: the amount of force you apply, and how far from the pivot point you apply the force. With an athlete’s center of mass closer to the ground, the athlete decreases the distance between the pivot point – the ground – and where the force of gravity is applied – the athlete’s center of mass.

Athletes need great strength to halt their motion mid-movement because they have to apply a force to resist the change in inertia.

…

It’s not just about the moves, clothing is a factor, Pope’s June 12, 2024 essay,

Many sports require a specific uniform. Breaking doesn’t – an athlete can wear whatever they want – but the right outfit will maximize their chance of success.

The athlete wants a shirt that minimizes the friction between their body and the ground during a spin. Lettering or images on the back of the shirt will add friction, which hinders an athlete’s ability to perform some down rock moves. An athlete may choose to wear long sleeves if they plan to slide on their elbows, as bare skin in contact with the floor provides more friction.

Athletes also have to think about the headgear they wear. …

There’s a bit more information about the breakdancing competition on the 2024 Olympics website.I cannot find a full list of athletes for the August 9, 2024 (B-Girls) and August 10, 2024 (B-Boys) competitions. There is this June 2, 2024 article (from the Associated Press) on the CBC (Canadian Broadcasting Corporation) online news website,

…

Victor Montalvo (B-boy Victor), United States: A breaker who describes himself as a student of old school b-boys from the founding era of hip-hop, the 30-year-old Montalvo, who is from Kissimmee, Florida, qualified for Paris by besting all other b-boys at the 2023 WDSF World Breaking Championship in Belgium.

Sunny Choi (B-girl Sunny), United States: The 35-year-old Choi, a cheerful Queens, New York-bred breaker, has long been an ambassador for b-girls globally. She qualified for the Paris Games with her win at the 2023 Pan American Games in Chile.

Philip Kim (B-boy Phil Wizard), Vancouver, Canada: Consistently ranked in the top three b-boys in the international breaking competitive community, Kim secured a spot for Paris when he came out on top at last year’s Pan American Games.

Dominika Banevič (B-girl Nicka), Lithuania: Banevič was the youngest in her category at last year’s WDSF World Breaking Championship, when she punched her ticket to Paris. Banevič turns 17 this month.

…

I thought the competition would be dominated by Americans and certainly wasn’t expecting to see a Lithuanian (Dominika Banevič or ‘Nicka’) listed as a competitor to watch. The Canadian (Philip Kim or ‘Phil Wizard’) is also a surprise. Who knew Vancouver was home to a leading B-boy?

Two comments: heat and mosquitoes (dengue and other fevers)

The organizers of the Paris 2024 Summer Olympics are to be complimented for their work towards making the games ‘green’ but that is a complex process.

Heat

For example, the Canadian Broadcasting Corporation (CBC) ran a news item on The National news telecast on June 17, 2024 (see telecast for embedded video clip) regarding concerns about and preparations for heat,

Preparing for extreme heat at the Paris Olympics

Paris Olympic organizers plan to make this summer’s games the greenest ever, but that includes offering less air conditioning to cut down on energy use. [emphases mine] As temperatures rise globally, some suggest the organizers should take extreme heat into account when awarding cities with the next big Olympic games.

Some of the reporting in the CBC news item is based on information from a June 18, 2024 University of Portsmouth (UK) press release, Note: Links have been removed,

Leading athletes are warning that intense heat at the Paris Olympics in July-August 2024 could lead to competitors collapsing and in worst case scenarios dying during the Games. [emphasis mine]

Eleven Olympians, including winners of five World Championships and six Olympic medals, have come together with climate scientists and leading heat physiologists Professor Mike Tipton and Dr Jo Corbett from the University of Portsmouth to unpack the serious threat extreme heat poses for athletes in a new Rings of Fire report.

Dr Corbett, Associate Professor of Environmental Physiology in the School of Sport, Health and Exercise Science at the University of Portsmouth, said: “A warming planet will present an additional challenge to athletes, which can adversely impact on their performance and diminish the sporting spectacle of the Olympic Games,. Hotter conditions also increase the potential for heat illness amongst all individuals exposed to high thermal stress, including officials and spectators, as well as athletes.”

“For athletes, from smaller performance-impacting issues like sleep disruption and last-minute changes to event timings, to exacerbated health impacts and heat related stress and injury, the consequences can be varied and wide-ranging. With global temperatures continuing to rise, climate change should increasingly be viewed as an existential threat to sport,” said Lord Sebastian Coe, President of World Athletics and four-time Olympic medallist.

The Tokyo Games became known as the “hottest in history,” with temperatures exceeding 34°C and humidity reaching nearly 70 per cent, leading to severe health risks for competitors. The Paris Games have the potential to surpass that, with climate change driven by the burning of fossil fuels contributing to record heat streaks during the past months.

2023 was the hottest year on record according to the EU’s [European Union] Copernicus Climate Change Service and 2024 has continued this streak. April 2024 was warmer globally than any previous April in the record books, said experts at Copernicus.

The Rings of Fire report discusses the deadly heatwave in France in 2003 – which killed over 14,000 people – and subsequent years of record-breaking temperatures, exceeding 42°C. It underscores the heightened risk of extreme heat during the Paris Olympics, especially considering the significant rise in the region’s temperatures since the city last hosted the Games a century ago.

…

You can find the Rings of Fire report here and the Corpernicus Climate Change Service here.

Mosquitoes and dengue and other fevers

Obviously, the world is changing as you can see in this June 18, 2024 Institut Pasteur press release (also on EurekAlert),

Olympics: how many days does it take for mosquitoes in Greater Paris to transmit arboviruses, and what preventive measures are needed?

The number of imported cases of dengue in the Greater Paris region increased significantly in the first few months of 2024. In the run-up to the Olympic Games, with huge numbers of international visitors set to come to Paris – especially from endemic dengue countries –, we need to be vigilant. Scientists from the Institut Pasteur, in collaboration with the Regional Mosquito Control Agency (ARD) and the National Reference Center for Arboviruses (Inserm-Irba), have demonstrated that the tiger mosquito, now present in Greater Paris, is capable of transmitting five viruses (West Nile, chikungunya, Usutu, Zika and dengue) within different time frames ranging from 3 to 21 days, at an external temperature of 28°C. These results highlight the importance of stepping up surveillance of imported cases of arboviruses this summer. The study was published on May 16 [2024] in Eurosurveillance.

Between January 1 and April 19, 2024, 1,679 imported dengue cases were reported in mainland France, 13 times more than the number reported over the same period the previous year (source SPF). It is likely that this number will increase during the Olympic Games, as more people come to Paris from countries that are endemic regions for other arboviruses. The vector for dengue transmission is Aedes albopictus, more commonly known as the tiger mosquito. Arboviruses are transmitted when a female mosquito bites a virus carrier and ingests viral particles. One particular feature of arboviruses is that they can replicate in mosquitoes (unlike other viruses such as influenza, which are destroyed when ingested by mosquitoes). The viral particles multiply and spread within the mosquito, reaching the salivary glands in a few days. When the female mosquito bites another human, she injects the virus while taking her blood meal.

The tiger mosquito is now present in 78 départements in mainland France, and this together with other climate change-related factors is facilitating vector-borne transmission. Scientists from the Institut Pasteur’s Arboviruses and Insect Vectors Unit, in collaboration with the Regional Vector Control Agency (ARD) and the National Reference Center for Arboviruses (Inserm-Irba), therefore decided to analyze the ability of Aedes albopictus in Greater Paris to transmit five arboviruses at a temperature of 28°C, which is likely in the region at this time of year, and counted the number of days between initial infection and the possibility of the virus being transmitted through a further mosquito bite. As well as the dengue, chikungunya and Zika viruses, which we already know can be transmitted by the tiger mosquito, the scientists studied the Usutu and West Nile viruses, which are naturally transmitted by another mosquito species, Culex pipiens (known as the “common mosquito”). Culex pipiens mosquitoes transmit viruses to humans after feeding on birds, which act as viral reservoirs.

Tiger mosquito susceptible to five arboviruses

Working in a BSL3 laboratory, the scientists studied the ability of tiger mosquitoes to transmit these five viruses and determined the extrinsic incubation period required for the virus to reach the mosquito’s salivary glands in sufficient quantities to infect a human. At 28°C, West Nile virus needs three days before it can be transmitted to humans by mosquitoes. The incubation period is 3 to 7 days for chikungunya and Usutu, and 14 to 21 days for dengue and Zika.(1) 

This information is crucial to gage the additional risk represented by the upcoming Olympic Games in Paris, which will see significant intermingling of populations combined with the return of travelers from endemic regions and a season conducive to mosquito proliferation. The findings can also be used to develop suitable control strategies.

“If a case of dengue is detected in the Greater Paris region, we now know that disinsection is required within 21 days. We can use these results to adjust our time frame for action and optimize our approach,” explains Anna-Bella Failloux, Head of the Institut Pasteur’s Arboviruses and Insect Vectors Unit, who led the study. “Depending on the temperatures we experience in and around Paris this summer, our findings will be essential for adjusting control measures as needed.”

What precautions should be taken in the run-up to the Olympics?

Health care professionals are trained to detect the symptoms of arboviruses if people indicate that they have recently been to an endemic country. The difficulty of surveillance is that many cases are asymptomatic: although dengue is a notifiable disease, up to 80% of cases lead to few or no symptoms. If a diagnosis of one of these diseases is confirmed, an inquiry is carried out by France’s Regional Health Agencies to determine where the individuals live or spent time in the days before the diagnosis, so that they can identify the areas where disinsection is needed. Anyone coming back from a foreign trip who experiences fever or aches is advised to see their family physician immediately and indicate the region they recently returned from.

“The alert system in France is effective. The applicable procedure and measures are already well established because France’s overseas territories in endemic regions have provided us with expertise in these diseases and know-how on epidemiological monitoring. My team is affiliated with the Arbo-France network, and we are contacted as soon as an arbovirus is detected,” continues Anna-Bella Failloux.

Since 2006, vector control measures in France have led to increased surveillance of tiger mosquitoes between May 1 and November 30 each year. This involves monitoring mosquito populations in areas where they are likely to be present; disease surveillance coordinated by Santé publique France based on reporting of viruses such as dengue, chikungunya and Zika by health care professionals; and raising awareness among people living in areas where mosquitoes have been reported. France’s Regional Health Agencies (ARS) and their operators are responsible for managing reporting, monitoring the presence of mosquitoes and taking rapid action in response to human cases of infection (vector control).

This research, which focused on mosquitoes in the Greater Paris region for this first study, will soon be extended to the rest of mainland France. Extrinsic incubation periods vary from one tiger mosquito population to the next because of differences in their genetic makeup and in local temperatures. 

Find out more:

Video: “We are going to have to learn to live with tiger mosquitoes” – Anna-Bella Failloux

Disease-carrying mosquitoes – French Ministry of Employment, Health and Solidarity (sante.gouv.fr)

  1. It is important to point out that for Usutu and West Nile, the ability of tiger mosquitoes to transmit these viruses to humans in real-life conditions, outside the experimental setting, is yet to be demonstrated, as they are naturally transmitted by Culex pipiens, another mosquito species.

Here’s a link to and a citation for the paper,

Aedes albopictus is a competent vector of five arboviruses affecting human health, greater Paris, France, 2023 by Chloé Bohers, Marie Vazeille, Lydia Bernaoui, Luidji Pascalin, Kevin Meignan, Laurence Mousson, Georges Jakerian, Anaïs Karchh, Xavier de Lamballerie, Anna-Bella Failloux. Euro Surveill. 2024; 29 (20): pii=2400271. DOI: https://doi.org/10.2807/1560-7917.ES.2024.29.20.2400271

This paper is open access.

I covered the movement of dengue fever and malaria into the Northern Hemisphere in an August 10, 2023 posting,

…

The World Health Organization (WHO) notes that dengue fever cases have increased exponentially since 2000 (from the March 17, 2023 version of the WHO’s “Dengue and severe dengue” fact sheet),

Global burden

The incidence of dengue has grown dramatically around the world in recent decades, with cases reported to WHO increased from 505 430 cases in 2000 to 5.2 million in 2019. A vast majority of cases are asymptomatic or mild and self-managed, and hence the actual numbers of dengue cases are under-reported. Many cases are also misdiagnosed as other febrile illnesses (1).

One modelling estimate indicates 390 million dengue virus infections per year of which 96 million manifest clinically (2). Another study on the prevalence of dengue estimates that 3.9 billion people are at risk of infection with dengue viruses.

The disease is now endemic in more than 100 countries in the WHO Regions of Africa, the Americas, the Eastern Mediterranean, South-East Asia and the Western Pacific. The Americas, South-East Asia and Western Pacific regions are the most seriously affected, with Asia representing around 70% of the global disease burden.

Dengue is spreading to new areas including Europe, [emphasis mine] and explosive outbreaks are occurring. Local transmission was reported for the first time in France and Croatia in 2010 [emphasis mine] and imported cases were detected in 3 other European countries.

…

The researchers from the University of Central Florida (UCF) couldn’t have known when they began their project to study mosquito bites and disease that Florida would register its first malaria cases in 20 years this summer, …

…

It seems pretty clear that there’s increasing concern about mosquito-borne diseases no matter where you live.

It looks like mega-sports events attract more visitors than you might expect.

Measuring quantum gravity

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It was about two years ago that a local (Vancouver, Canada) group of movers and shakers announced the launch of a Vancouver-based Quantum Gravity Institute at the Quantum Mechanics & Gravity conference (August 15 – 19, 2022) in my July 26, 2022 posting where I also provided an overview of the doings in the Canadian quantum scene. (I can’t find an online presence for the institute but there is the Vancouver-based Quantum Gravity Society which organized the 2022 conference and the institute.)

All of this being the buildup to a quantum gravity announcement in a February 23, 2024 news item on Nanowerk,

Scientists are a step closer to unravelling the mysterious forces of the universe after working out how to measure gravity on a microscopic level.

Experts have never fully understood how the force which was discovered by Isaac Newton works in the tiny quantum world.

Even Einstein was baffled by quantum gravity and, in his theory of general relativity, said there is no realistic experiment which could show a quantum version of gravity.

But now physicists at the University of Southampton [UK], working with scientists in Europe, have successfully detected a weak gravitational pull on a tiny particle using a new technique.

They claim it could pave the way to finding the elusive quantum gravity theory.

…

A February 26, 2024 University of Southampton press release, also on EurekAlert but published on February 23, 2024, delves further into quantum gravity,

…

The experiment, published in the Science Advances journal, used levitating magnets to detect gravity on microscopic particles – small enough to boarder on the quantum realm.

Lead author Tim Fuchs, from the University of Southampton, said the results could help experts find the missing puzzle piece in our picture of reality.

He added: “For a century, scientists have tried and failed to understand how gravity and quantum mechanics work together.

“Now we have successfully measured gravitational signals at a smallest mass ever recorded, it means we are one step closer to finally realising how it works in tandem.

“From here we will start scaling the source down using this technique until we reach the quantum world on both sides.

“By understanding quantum gravity, we could solve some of the mysteries of our universe – like how it began, what happens inside black holes, or uniting all forces into one big theory.”

The rules of the quantum realm are still not fully understood by science – but it is believed that particles and forces at a microscopic scale interact differently than regular-sized objects.

Academics from Southampton conducted the experiment with scientists at Leiden University in the Netherlands and the Institute for Photonics and Nanotechnologies in Italy, with funding from the EU Horizon Europe EIC Pathfinder grant (QuCoM).

Their study used a sophisticated setup involving superconducting devices, known as traps, with magnetic fields, sensitive detectors and advanced vibration isolation.

It measured a weak pull, just 30aN, on a tiny particle 0.43mg in size by levitating it in freezing temperatures a hundredth of a degree above absolute zero – about minus-273 degrees Celsius.

The results open the door for future experiments between even smaller objects and forces, said Professor of Physics Hendrik Ulbricht also at the University of Southampton.

He added: “We are pushing the boundaries of science that could lead to new discoveries about gravity and the quantum world.

“Our new technique that uses extremely cold temperatures and devices to isolate vibration of the particle will likely prove the way forward for measuring quantum gravity.

“Unravelling these mysteries will help us unlock more secrets about the universe’s very fabric, from the tiniest particles to the grandest cosmic structures.”

Here’s a link to and a citation for the paper,

Measuring gravity with milligram levitated masses by Tim M. Fuchs, Dennis G. Uitenbroek, Jaimy Plugge, Noud van Halteren, Jean-Paul van Soest, Andrea Vinante, Hendrik Ulbricht, and Tjerk H. Oosterkamp. Science Advances 23 Feb 2024 Vol 10, Issue 8 DOI: 10.1126/sciadv.adk2949

This paper is open access.