Category Archives: robots

Biobots (also known as biohybrid robots) occupy a third state between life and death?

I got a bit of a jolt from this September 12, 2024 essay by Peter A Noble, affiliate professor of microbiology at the University of Washington, and Alex Pozhitkov, senior technical lead of bioinformatics, Irell & Manella Graduate School of Biological Sciences at City of Hope, for The Conversation (h/t Sept. 12, 2024 item on phys.org), Note: Links have been removed,

Life and death are traditionally viewed as opposites. But the emergence of new multicellular life-forms from the cells of a dead organism introduces a “third state” that lies beyond the traditional boundaries of life and death.

Usually, scientists consider death to be the irreversible halt of functioning of an organism as a whole. However, practices such as organ donation highlight how organs, tissues and cells can continue to function even after an organism’s demise. This resilience raises the question: What mechanisms allow certain cells to keep working after an organism has died?

We are researchers who investigate what happens within organisms after they die. In our recently published review, we describe how certain cells – when provided with nutrients, oxygen, bioelectricity or biochemical cues – have the capacity to transform into multicellular organisms with new functions after death.

Life, death and emergence of something new

The third state challenges how scientists typically understand cell behavior. While caterpillars metamorphosing into butterflies, or tadpoles evolving into frogs, may be familiar developmental transformations, there are few instances where organisms change in ways that are not predetermined. Tumors, organoids and cell lines that can indefinitely divide in a petri dish, like HeLa cells [cervical cancer cells taken from Henrietta Lacks without her knowledge], are not considered part of the third state because they do not develop new functions.

However, researchers found that skin cells extracted from deceased frog embryos were able to adapt to the new conditions of a petri dish in a lab, spontaneously reorganizing into multicellular organisms called xenobots [emphasis mine]. These organisms exhibited behaviors that extend far beyond their original biological roles. Specifically, these xenobots use their cilia – small, hair-like structures – to navigate and move through their surroundings, whereas in a living frog embryo, cilia are typically used to move mucus.

Xenobots are also able to perform kinematic self-replication, meaning they can physically replicate their structure and function without growing. This differs from more common replication processes that involve growth within or on the organism’s body.

Researchers have also found that solitary human lung cells can self-assemble into miniature multicellular organisms that can move around. These anthrobots [emphasis mine] behave and are structured in new ways. They are not only able to navigate their surroundings but also repair both themselves and injured neuron cells placed nearby.

Taken together, these findings demonstrate the inherent plasticity of cellular systems and challenge the idea that cells and organisms can evolve only in predetermined ways. The third state suggests that organismal death may play a significant role in how life transforms over time.

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I had not realized that xenobots are derived from dead frog embryos something I missed when mentioning or featuring them in previous stories, the latest in a September 13, 2024 posting, which also mentions anthrobots. Previous stories were published in a June 21, 2021 posting about xenobots 2.0 and their ability to move and a June 8, 2022 posting about their ability to reproduce. Thank you to the authors for relieving me of some of my ignorance.

For some reason I was expecting mention, brief or otherwise, of ethical or social implications but the authors offered this instead, from their September 12, 2024 essay, Note: Links have been removed,

Implications for biology and medicine

The third state not only offers new insights into the adaptability of cells. It also offers prospects for new treatments.

For example, anthrobots could be sourced from an individual’s living tissue to deliver drugs without triggering an unwanted immune response. Engineered anthrobots injected into the body could potentially dissolve arterial plaque in atherosclerosis patients and remove excess mucus in cystic fibrosis patients.

Importantly, these multicellular organisms have a finite life span, naturally degrading after four to six weeks. This “kill switch” prevents the growth of potentially invasive cells.

A better understanding of how some cells continue to function and metamorphose into multicellular entities some time after an organism’s demise holds promise for advancing personalized and preventive medicine.

I look forward to hearing about the third state and about any ethical or social issues that may arise from it.

Moving past xenobots (living robots based on frog stem cells)

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Laura Tran’s June 14, 2024 article for The Scientist gives both a brief history of Michael Levin’s and his team’s work on developing living robots using stem cells from an African clawed frog (known as Xenopus laevis) and offers an update on the team’s work into synthetic lifeforms. First, the xenobots, Note 1: This could be difficult for people with issues regarding animal experimentation Note 1: Links have been removed,

Ibegan with little pieces of embryos scooting around in a dish. In 1998, these unassuming cells caught the attention of Michael Levin, then a postdoctoral researcher studying cell biology at Harvard University. He recalled simply recording a video before tucking the memory away. Nearly two decades later, Levin, now a developmental and synthetic biologist at Tufts University, experienced a sense of déjà vu. He observed that as a student transplanted tissues from one embryo to another, some loose cells swam free in the dish.

Levin had a keen interest in the collective intelligence of cells, tissues, organs, and artificial constructs within regenerative medicine, and he wondered if he could explore the plasticity and harness the untapped capabilities of these swirling embryonic stem cells. “At that point, I started thinking that this is probably an amazing biorobotics platform,” recalled Levin. He rushed to describe this idea to Douglas Blackiston, a developmental and synthetic biologist at Tufts University who worked alongside Levin.

At the time, Blackiston was conducting plasticity research to restore vision in blind African clawed frog tadpoles, Xenopus laevis, a model organism used to understand development. Blackiston transplanted the eyes to unusual places, such as the back of the head or even the tail, to test the integration of transplanted sensory organs.¹ The eye axons extended to either the gut or spinal cord. In a display of dynamic plasticity, transplanted eyes on the tail that extended an optic nerve into the spinal cord restored the tadpoles’ vision.²

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In a similar vein, Josh Bongard, an evolutionary roboticist at the University of Vermont and Levin’s longtime colleague, pondered how robots could evolve like animals. He wanted to apply biological evolution to a machine by tinkering with the brains and bodies of robots and explored this idea with Sam Kriegman, then a graduate student in Bongard’s group and now an assistant professor at Northwestern University. Kriegman used evolutionary algorithms and artificial intelligence (AI) to simulate biological evolution in a virtual creature before teaming up with engineers to construct a physical version.

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i have two stories about the Xenobots. I was a little late to the party, so, the June 21, 2021 posting is about xenobots 2.0 and their ability to move and the June 8, 2022 posting is about their ability to reproduce.

Tran’s June 14, 2024 article provides the latest update, Note: Links have been removed,

Evolving Beyond the Xenobot

“People thought this was a one-off froggy-specific result, but this is a very profound thing,” emphasized Levin. To demonstrate its translatability in a non-frog model, he wondered, “What’s the furthest from an embryonic frog? Well, that would be an adult human.”

He enlisted the help of Gizem Gumuskaya, a synthetic biologist with an architectural background in Levin’s group, to tackle this challenge of creating biological robots using human cells to create anthrobots.⁸ While Gumuskaya was not involved with the development of xenobots, she drew inspiration from their design. By using adult human tracheal cells, she found that adult cells still displayed morphologic plasticity.

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There are several key differences between xenobots and anthrobots: species, cell source (embryonic or adult), and the anthrobots’ ability to self-assemble without manipulation. “When considering applications, as a rule of thumb, xenobots are better suited to the environment. They exhibit higher durability, require less maintenance, and can coexist within the environment,” said Gumuskaya.

Meanwhile, there is greater potential for the use of mammalian-derived biobots in biomedical applications. This could include localized drug delivery, deposition into the arteries to break up plaque buildup, or deploying anthrobots into tissue to act as biosensors. “[Anthrobots] are poised as a personalized agent with the same DNA but new functionality,” remarked Gumuskaya.

…

Here’s a link to and a citation for the team’s latest paper,

Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells by Gizem Gumuskaya, Pranjal Srivastava, Ben G. Cooper, Hannah Lesser, Ben Semegran, Simon Garnier, Michael Levin. Advanced Science Volume 11, Issue 4 January 26, 2024 2303575 DOI: https://doi.org/10.1002/advs.202303575 First published: 30 November 2023

This paper is open access.

Bio-hybrid robotics (living robots) needs public debate and regulation

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A July 23, 2024 University of Southampton (UK) press release (also on EurekAlert but published July 22, 2024) describes the emerging science/technology of bio-hybrid robotics and a recent study about the ethical issues raised, Note 1: bio-hybrid may also be written as biohybrid; Note 2: Links have been removed,

Development of ‘living robots’ needs regulation and public debate

Researchers are calling for regulation to guide the responsible and ethical development of bio-hybrid robotics – a ground-breaking science which fuses artificial components with living tissue and cells.

In a paper published in Proceedings of the National Academy of Sciences [PNAS] a multidisciplinary team from the University of Southampton and universities in the US and Spain set out the unique ethical issues this technology presents and the need for proper governance.

Combining living materials and organisms with synthetic robotic components might sound like something out of science fiction, but this emerging field is advancing rapidly. Bio-hybrid robots using living muscles can crawl, swim, grip, pump, and sense their surroundings. Sensors made from sensory cells or insect antennae have improved chemical sensing. Living neurons have even been used to control mobile robots.

Dr Rafael Mestre from the University of Southampton, who specialises in emergent technologies and is co-lead author of the paper, said: “The challenges in overseeing bio-hybrid robotics are not dissimilar to those encountered in the regulation of biomedical devices, stem cells and other disruptive technologies. But unlike purely mechanical or digital technologies, bio-hybrid robots blend biological and synthetic components in unprecedented ways. This presents unique possible benefits but also potential dangers.”

Research publications relating to bio-hybrid robotics have increased continuously over the last decade. But the authors found that of the more than 1,500 publications on the subject at the time, only five considered its ethical implications in depth.

The paper’s authors identified three areas where bio-hybrid robotics present unique ethical issues: Interactivity – how bio-robots interact with humans and the environment, Integrability – how and whether humans might assimilate bio-robots (such as bio-robotic organs or limbs), and Moral status.

In a series of thought experiments, they describe how a bio-robot for cleaning our oceans could disrupt the food chain, how a bio-hybrid robotic arm might exacerbate inequalities [emphasis mine], and how increasing sophisticated bio-hybrid assistants could raise questions about sentience and moral value.

“Bio-hybrid robots create unique ethical dilemmas,” says Aníbal M. Astobiza, an ethicist from the University of the Basque Country in Spain and co-lead author of the paper. “The living tissue used in their fabrication, potential for sentience, distinct environmental impact, unusual moral status, and capacity for biological evolution or adaptation create unique ethical dilemmas that extend beyond those of wholly artificial or biological technologies.”

The paper is the first from the Biohybrid Futures project led by Dr Rafael Mestre, in collaboration with the Rebooting Democracy project. Biohybrid Futures is setting out to develop a framework for the responsible research, application, and governance of bio-hybrid robotics.

The paper proposes several requirements for such a framework, including risk assessments, consideration of social implications, and increasing public awareness and understanding.

Dr Matt Ryan, a political scientist from the University of Southampton and a co-author on the paper, said: “If debates around embryonic stem cells, human cloning or artificial intelligence have taught us something, it is that humans rarely agree on the correct resolution of the moral dilemmas of emergent technologies.

“Compared to related technologies such as embryonic stem cells or artificial intelligence, bio-hybrid robotics has developed relatively unattended by the media, the public and policymakers, but it is no less significant. We want the public to be included in this conversation to ensure a democratic approach to the development and ethical evaluation of this technology.”

In addition to the need for a governance framework, the authors set out actions that the research community can take now to guide their research.

“Taking these steps should not be seen as prescriptive in any way, but as an opportunity to share responsibility, taking a heavy weight away from the researcher’s shoulders,” says Dr Victoria Webster-Wood, a biomechanical engineer from Carnegie Mellon University in the US and co-author on the paper.

“Research in bio-hybrid robotics has evolved in various directions. We need to align our efforts to fully unlock its potential.”

Here’s a link to and a citation for the paper,

Ethics and responsibility in biohybrid robotics research by Rafael Mestre, Aníbal M. Astobiza, Victoria A. Webster-Wood, Matt Ryan, and M. Taher A. Saif. PNAS 121 (31) e2310458121 July 23, 2024 DOI: https://doi.org/10.1073/pnas.2310458121

This paper is open access.

Cyborg or biohybrid robot?

Earlier, I highlighted “… how a bio-hybrid robotic arm might exacerbate inequalities …” because it suggests cyborgs, which are not mentioned in the press release or in the paper, This seems like an odd omission but, over the years, terminology does change although it’s not clear that’s the situation here.

I have two ‘definitions’, the first is from an October 21, 2019 article by Javier Yanes for OpenMind BBVA, Note: More about BBVA later,

…

The fusion between living organisms and artificial devices has become familiar to us through the concept of the cyborg (cybernetic organism). This approach consists of restoring or improving the capacities of the organic being, usually a human being, by means of technological devices. On the other hand, biohybrid robots are in some ways the opposite idea: using living tissues or cells to provide the machine with functions that would be difficult to achieve otherwise. The idea is that if soft robots seek to achieve this through synthetic materials, why not do so directly with living materials?

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In contrast, there’s this from “Biohybrid robots: recent progress, challenges, and perspectives,” Note 1: Full citation for paper follows excerpt; Note 2: Links have been removed,

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2.3. Cyborgs

Another approach to building biohybrid robots is the artificial enhancement of animals or using an entire animal body as a scaffold to manipulate robotically. The locomotion of these augmented animals can then be externally controlled, spanning three modes of locomotion: walking/running, flying, and swimming. Notably, these capabilities have been demonstrated in jellyfish (figure 4(A)) [139, 140], clams (figure 4(B)) [141], turtles (figure 4(C)) [142, 143], and insects, including locusts (figure 4(D)) [27, 144], beetles (figure 4(E)) [28, 145–158], cockroaches (figure 4(F)) [159–165], and moths [166–170].

….

The advantages of using entire animals as cyborgs are multifold. For robotics, augmented animals possess inherent features that address some of the long-standing challenges within the field, including power consumption and damage tolerance, by taking advantage of animal metabolism [172], tissue healing, and other adaptive behaviors. In particular, biohybrid robotic jellyfish, composed of a self-contained microelectronic swim controller embedded into live Aurelia aurita moon jellyfish, consumed one to three orders of magnitude less power per mass than existing swimming robots [172], and cyborg insects can make use of the insect’s hemolymph directly as a fuel source [173].

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So, sometimes there’s a distinction and sometimes there’s not. I take this to mean that the field is still emerging and that’s reflected in evolving terminology.

Here’s a link to and a citation for the paper,

Biohybrid robots: recent progress, challenges, and perspectives by Victoria A Webster-Wood, Maria Guix, Nicole W Xu, Bahareh Behkam, Hirotaka Sato, Deblina Sarkar, Samuel Sanchez, Masahiro Shimizu and Kevin Kit Parker. Bioinspiration & Biomimetics, Volume 18, Number 1 015001 DOI 10.1088/1748-3190/ac9c3b Published 8 November 2022 • © 2022 The Author(s). Published by IOP Publishing Ltd

This paper is open access.

A few notes about BBVA and other items

BBVA is Banco Bilbao Vizcaya Argentaria according to its Wikipedia entry, Note: Links have been removed,

Banco Bilbao Vizcaya Argentaria, S.A. (Spanish pronunciation: [ˈbaŋko βilˈβao βiθˈkaʝa aɾxenˈtaɾja]), better known by its initialism BBVA, is a Spanish multinational financial services company based in Madrid and Bilbao, Spain. It is one of the largest financial institutions in the world, and is present mainly in Spain, Portugal, Mexico, South America, Turkey, Italy and Romania.^[2]

BBVA’s OpenMind is, from their About us page,

OpenMind: BBVA’s knowledge community

OpenMind is a non-profit project run by BBVA that aims to contribute to the generation and dissemination of knowledge about fundamental issues of our time, in an open and free way. The project is materialized in an online dissemination community.

“Sharing knowledge for a better future“.

At OpenMind we want to help people understand the main phenomena affecting our lives; the opportunities and challenges that we face in areas such as science, technology, humanities or economics. Analyzing the impact of scientific and technological advances on the future of the economy, society and our daily lives is the project’s main objective, which always starts on the premise that a broader and greater quality knowledge will help us to make better individual and collective decisions.

As for other items, you can find my latest (biorobotic, cyborg, or bionic depending what terminology you what to use) jellyfish story in this June 6, 2024 posting, the Biohybrid Futures project mentioned in the press release here, and also mentioned in the Rebooting Democracy project (unexpected in the context of an emerging science/technology) can be found here on this University of Southampton website.

Finally, you can find more on these stories (science/technology announcements and/or ethics research/issues) here by searching for ‘robots’ (tag and category), ‘cyborgs’ (tag), ‘machine/flesh’ (tag), ‘neuroprosthetic’ (tag), and human enhancement (category).

Bionic jellyfish for deep ocean exploration

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This research may be a little disturbing for animal lovers as it involves conjoining a jellyfish (or sea jelly) and a robotic device. That said, a February 29, 2024 news item on ScienceDaily highlights new research into the oceanic depths,

Jellyfish can’t do much besides swim, sting, eat, and breed. They don’t even have brains. Yet, these simple creatures can easily journey to the depths of the oceans in a way that humans, despite all our sophistication, cannot.
But what if humans could have jellyfish explore the oceans on our behalf, reporting back what they find? New research conducted at Caltech [California Institute of Technology] aims to make that a reality through the creation of what researchers call biohybrid robotic jellyfish. These creatures, which can be thought of as ocean-going cyborgs, augment jellyfish with electronics that enhance their swimming and a prosthetic “hat” that can carry a small payload while also making the jellyfish swim in a more streamlined manner.
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The researchers describe their work and provide recordings of the jellyfish,

A February 28, 2024 California Institute of Technology (Caltech) news release (also on EurekAlert) by Emily Velasco, which originated the news item, provides more detail,

The work, published in the journal Bioinspiration & Biomimetics, was conducted in the lab of John Dabiri (MS ’03, PhD ’05), the Centennial Professor of Aeronautics and Mechanical Engineering, and builds on his previous work augmenting jellyfish. Dabiri’s goal with this research is to use jellyfish as robotic data-gatherers, sending them into the oceans to collect information about temperature, salinity, and oxygen levels, all of which are affected by Earth’s changing climate.
“It’s well known that the ocean is critical for determining our present and future climate on land, and yet, we still know surprisingly little about the ocean, especially away from the surface,” Dabiri says. “Our goal is to finally move that needle by taking an unconventional approach inspired by one of the few animals that already successfully explores the entire ocean.”
Throughout his career, Dabiri has looked to the natural world, jellyfish included, for inspiration in solving engineering challenges. This work began with early attempts by Dabiri’s lab to develop a mechanical robot that swam like jellyfish, which have the most efficient method for traveling through water of any living creature. Though his research team succeeded in creating such a robot, that robot was never able to swim as efficiently as a real jellyfish. At that point, Dabiri asked himself, why not just work with jellyfish themselves?
“Jellyfish are the original ocean explorers, reaching its deepest corners and thriving just as well in tropical or polar waters,” Dabiri says. “Since they don’t have a brain or the ability to sense pain, we’ve been able to collaborate with bioethicists to develop this biohybrid robotic application in a way that’s ethically principled.”
Previously, Dabiri’s lab implanted jellyfish with a kind of electronic pacemaker that controls the speed at which they swim. In doing so, they found that if they made jellyfish swim faster than the leisurely pace they normally keep, the animals became even more efficient. A jellyfish swimming three times faster than it normally would uses only twice as much energy.
This time, the research team went a step further, adding what they call a forebody to the jellies. These forebodies are like hats that sit atop the jellyfish’s bell (the mushroom-shaped part of the animal). The devices were designed by graduate student and lead author Simon Anuszczyk (MS ’22), who aimed to make the jellyfish more streamlined while also providing a place where sensors and other electronics can be carried.
“Much like the pointed end of an arrow, we designed 3D-printed forebodies to streamline the bell of the jellyfish robot, reduce drag, and increase swimming performance,” Anuszczyk says. “At the same time, we experimented with 3D printing until we were able to carefully balance the buoyancy and keep the jellyfish swimming vertically.”
To test the augmented jellies’ swimming abilities, Dabiri’s lab undertook the construction of a massive vertical aquarium inside Caltech’s Guggenheim Laboratory. Dabiri explains that the three-story tank is tall, rather than wide, because researchers want to gather data on oceanic conditions far below the surface.
“In the ocean, the round trip from the surface down to several thousand meters will take a few days for the jellyfish, so we wanted to develop a facility to study that process in the lab,” Dabiri says. “Our vertical tank lets the animals swim against a flowing vertical current, like a treadmill for swimmers. We expect the unique scale of the facility—probably the first vertical water treadmill of its kind—to be useful for a variety of other basic and applied research questions.”
Swim tests conducted in the tank show that a jellyfish equipped with a combination of the swimming pacemaker and forebody can swim up to 4.5 times faster than an all-natural jelly while carrying a payload. The total cost is about $20 per jellyfish, Dabiri says, which makes biohybrid jellies an attractive alternative to renting a research vessel that can cost more than $50,000 a day to run.
“By using the jellyfish’s natural capacity to withstand extreme pressures in the deep ocean and their ability to power themselves by feeding, our engineering challenge is a lot more manageable,” Dabiri adds. “We still need to design the sensor package to withstand the same crushing pressures, but that device is smaller than a softball, making it much easier to design than a full submarine vehicle operating at those depths.
“I’m really excited to see what we can learn by simply observing these parts of the ocean for the very first time,” he adds.
Dabiri says future work may focus on further enhancing the bionic jellies’ abilities. Right now, they can only be made to swim faster in a straight line, such as the vertical paths being designed for deep ocean measurement. But further research may also make them steerable, so they can be directed horizontally as well as vertically.
The paper describing the work, “Electromechanical enhancement of live jellyfish for ocean exploration,” appears in the XX issue of Bioinspiration & Biomimetics. Co-authors are Anuszczyk and Dabiri.
Funding for the research was provided by the National Science Foundation and the Charles Lee Powell Foundation.

Here’s a link to and a citation for the paper,

Electromechanical enhancement of live jellyfish for ocean exploration by Simon R Anuszczyk and John O Dabiri. Bioinspiration & Biomimetics, Volume 19, Number 2 DOI 10.1088/1748-3190/ad277f Published 28 February 2024

This paper is open access.

Digi, Nano, Bio, Neuro – why should we care more about converging technologies?

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Personality in focus: the convergence of biology and computer technology could make extremely sensitive data available. (Image: by-studio / AdobeStock) [downloaded from https://ethz.ch/en/news-and-events/eth-news/news/2024/05/digi-nano-bio-neuro-or-why-we-should-care-more-about-converging-technologies.html]

I gave a guest lecture some years ago where I mentioned that I thought the real issue with big data and AI (artificial intelligence) lay in combining them (or convergence). These days, it seems I was insufficiently imaginative as researchers from ETH Zurich have taken the notion much further.

From a May 7, 2024 ETH Zurich press release (also on EurekAlert), Note: You’ll see in the ‘References’ some extra words, ‘external page’ is self-explanatory but ‘call made’ remains a mystery to me,

In my research, I [Dirk Helbing, Professor of Computational Social Science at the Department of Humanities, Social and Political Sciences and associated with the Department of Computer Science at ETH Zurich.] deal with the consequences of digitalisation for people, society and democracy. In this context, it is also important to keep an eye on their convergence in computer and life sciences – i.e. what becomes possible when digital technologies grow increasingly together with biotechnology, neurotechnology and nanotechnology.

Converging technologies are seen as a breeding ground for far-reaching innovations. However, they are blurring the boundaries between the physical, biological and digital worlds. Conventional regulations are becoming ineffective as a result.

In a joint study I conducted with my co-author Marcello Ienca, we have recently examined the risks and societal challenges of technological convergence – and concluded that the effects for individuals and society are far-reaching.

We would like to draw attention to the challenges and risks of converging technologies and explain why we consider it necessary to accompany technological developments internationally with strict regulations.

For several years now, everyone has been able to observe, within the context of digitalisation, the consequences of leaving technological change to market forces alone without effective regulation.

Misinformation and manipulation on the web

The Digital Manifesto was published in 2015 – almost ten years ago.¹ Nine European experts, including one from ETH Zurich, issued an urgent warning against scoring, i.e. the evaluation of people, and big nudging,² a subtle form of digital manipulation. The latter is based on personality profiles created using cookies and other surveillance data. A little later, the Cambridge Analytica scandal alerted the world to how the data analysis company had been using personalised ads (microtargeting) in an attempt to manipulate voting behaviour in democratic elections.

This has brought democracies around the world under considerable pressure. Propaganda, fake news and hate speech are polarising and sowing doubt, while privacy is on the decline. We are in the midst of an international information war for control of our minds, in which advertising companies, tech corporations, secret services and the military are fighting to exert an influence on our mindset and behaviour. The European Union has adopted the AI Act in an attempt to curb these dangers.

However, digital technologies have developed at a breathtaking pace, and new possibilities for manipulation are already emerging. The merging of digital and nanotechnology with modern biotechnology and neurotechnology makes revolutionary applications possible that had been hardly imaginable before.

Microrobots for precision medicine

In personalised medicine, for example, the advancing miniaturisation of electronics is making it increasingly possible to connect living organisms and humans with networked sensors and computing power. The WEF [World Economic Forum] proclaimed the “Internet of Bodies” as early as 2020.^3, ⁴

One example that combines conventional medication with a monitoring function is digital pills. These could control medication and record a patient’s physiological data (see this blog post).

Experts expect sensor technology to reach the nanoscale. Magnetic nanoparticles or nanoelectronic components, i.e. tiny particles invisible to the naked eye with a diameter up to 100 nanometres, would make it possible to transport active substances, interact with cells and record vast amounts of data on bodily functions. If introduced into the body, it is hoped that diseases could be detected at an early stage and treated in a personalised manner. This is often referred to as high-precision medicine.

Nano-electrodes record brain function

Miniaturised electrodes that can simultaneously measure and manipulate the activity of thousands of neurons coupled with ever-improving AI tools for the analysis of brain signals are approaches that are now leading to much-discussed advances in the brain-computer interface. Brain activity mapping is also on the agenda. Thanks to nano-neurotechnology, we could soon envisage smartphones and other AI applications being controlled directly by thoughts.

“Long before precision medicine and neurotechnology work reliably, these technologies will be able to be used against people.” Dirk Helbling

Large-scale projects to map the human brain are also likely to benefit from this.⁵ In future, brain activity mapping will not only be able to read our thoughts and feelings but also make them possible of being influenced remotely – the latter would probably be a lot more effective than previous manipulation methods like big nudging.

However, conventional electrodes are not suitable for permanent connection between cells and electronics – this requires durable and biocompatible interfaces. This has given rise to the suggestion of transmitting signals optogenetically, i.e. to control genes in special cells with light pulses.⁶ This would make the implementation of amazing circuits possible (see this ETH News article [November 11, 2014 press release] “Controlling genes with thoughts” ).

The downside of convergence

Admittedly, the applications mentioned above may sound futuristic, with most of them still visions or in their early stages of development. However, a lot of research is being conducted worldwide and at full speed. The military is also interested in using converging technologies for its own purposes. ^{7, 8}

The downside of convergence is the considerable risks involved, such as state or private players gaining access to highly sensitive data and misusing it to monitor and influence people. The more connected our bodies become, the more vulnerable we will be to cybercrime and hacking. It cannot be ruled out that military applications exist already.⁵ One thing is clear, however: long before precision medicine and neurotechnology work reliably, these technologies will be able to be used against people.

“We need to regain control of our personal data. To do this, we need genuine informational self-determination.” Dirk Helbling

The problem is that existing regulations are specific and insufficient to keep technological convergence in check. But how are we to retain control over our lives if it becomes increasingly possible to influence our thoughts, feelings and decisions by digital means?

Converging global regulation is needed

In our recent paper we conclude that any regulation of converging technologies would have to be based on converging international regulations. Accordingly, we outline a new global regulatory framework and propose ten governance principles to close the looming regulatory gap.⁹

The framework emphasises the need for safeguards to protect bodily and mental functions from unauthorised interference and to ensure personal integrity and privacy by, for example. establishing neurorights.

To minimise risks and prevent abuse, future regulations should be inclusive, transparent and trustworthy. The principle of participatory governance is key, which would have to involve all the relevant groups and ensure that the concerns of affected minorities are also taken into account in decision-making processes.

Finally, we need to regain control of our personal data. To accomplish this, we need genuine informational self-determination. This would also have to apply to the digital twins of our body and personality, because they can be used to hack our health and our way of thinking – for good or for bad.¹⁰

With our contribution, we would like to initiate public debate about converging technologies. Despite its major relevance, we believe that too little attention is being paid to this topic. Continuous discourse on benefits, risks and sensible rules can help to steer technological convergence in such a way that it serves people instead of harming them.

Dirk Helbing wrote this article together with external page Marcello Ienca call_made, who previously worked at ETH Zurich and EPFL and is now Assistant Professor of Ethics of AI and Neuroscience at the Technical University of Munich.

References

¹ Digital-Manifest: external page Digitale Demokratie statt Datendiktatur call_made (2015) Spektrum der Wissenschaft

² external page Sie sind das Ziel! call_made (2024) Schweizer Monat

³ external page The Internet of Bodies Is Here: Tackling new challenges of technology governance call_made (2020) World Economic Forum

⁴ external page Tracking how our bodies work could change our lives call_made (2020) World Economic Forum

⁵ external page Nanotools for Neuroscience and Brain Activity Mapping call_made (2013) ACS Nano

⁶ external page Innovationspotenziale der Mensch-Maschine-Interaktion call_made (2016) Deutsche Akademie der Technikwissenschaften

⁷ external page Human Augmentation – The Dawn of a New Paradigm. A strategic implications project call_made (2021) UK Ministry of Defence

⁸ external page Behavioural change as the core of warfighting call_made (2017) Militaire Spectator

⁹ Helbing D, Ienca M: external page Why converging technologies need converging international regulation call_made (2024) Ethics and Information Technology

¹⁰ external page Who is Messing with Your Digital Twin? Body, Mind, and Soul for Sale? call_made Dirk Helbing TEDx Talk (2023)

Here’s a second link to and citation for the paper,

Why converging technologies need converging international regulation by Dirk Helbing & Marcello Ienca. Ethics and Information Technology Volume 26, article number 15, (2024) DOI: 10.1007/s10676-024-09756-8 Published: 28 February 2024

This paper is open access.

A March 15, 2024 performance with sound sculptor and roboticist Moritz Simon Geist at SxSW (Texas) and two April 2024 TED talks in Vancouver (Canada)

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SxSW 2024 (Austin, Texas, US)

Here’s a preview of what you’ll be seeing if you are in Austin, Texas at SxSW 2024 for Moritz Simon Geist’s March 15, 2024 performance,

I have more details from a March 11, 2024 SxSW announcement (received via email),

Innovative Sound Sculptor and Roboticist Moritz Simon Geist Plays the MUTEK/Houndstoooth Showcase at Central Presbyterian Church March 15th [2024]
Event Details Date: March 15th [2024], 8:00 pm
Lineup
7:30 pm – Doors
8:00-8:40 pm – Moritz Simon Geist
9:00-9:40 pm – JFDR
10:00-10:40 pm – Hinako
11:00-11:50 pm – Aisha
…
“Geist’s handmade robots made movements as simple as a ping-pong table flapping or coiling up to shoot, but the contact microphones and sound processing documented a percussive, electro, mini symphony.”  – Austin Chronicle
There’s mystery in Geist’s music. It’s heady, ASMR-infused dance music — there’s something special happening here, but it’s not immediately clear what.” –– Engadget
“For Geist, the instruments represent not just a new way to make music, but a new way to experience it. The instruments each have a visual component, which makes it possible to watch the sounds as Geist creates them.” – Wired
The performance is fascinating and bewildering, but the music itself provokes one to want to dance in a dimly lit nightclub.”  – MixMag
“It doesn’t get geekier than this”  – New York Times.
“These robots play electrifying techno music.”– CNET
German sonic artist Moritz Simon Geist will showcase his latest work “Don’t Look At Me” at the Central Presbyterian Church March 15th. With his new robotic instrument Geist is presenting a contemplative ambient performance around the themes attention economy, spatial sound and sine waves. “Don’t Look at Me” was developed as an interactive installation in 2023 in South Korea and uses resonator tubes, light, and vibrato elements to create a fascinating ever-changing soundscape. For the SXSW event, Geist is showcasing his latest compositions with this instrument.
Moritz is returning to SXSW 2024 with a handful of performances and robotic interventions. His works and performances revolve around the questions: How do machines, algorithms and humans interact? How can we find a playful way to interact with non-human music players? And can robots play techno?
Moritz and his team have been developing sound machines and kinetic installations for more than 10 years already, and his works and performances have been shown at festivals and stages around the world. For this SXSW, Moritz is bringing both performances for several techno shows as well as a contemplative ambient show at the Central Presbyterian Church on March 15th [2024]. Here he will present compositions for his latest work “Don’t Look At Me”.
Geist is well known for his performances and self-developed instruments using robots and mechanics as the main sound source. His works have been shown internationally and have been awarded numerous awards in the last years.
Of his return to SXSW, Moritz says, “SXSW 2024 is only the second time I’m playing ‘Don’t Look at Me’ with my new robotic instrument! Playing with a new instrument this complex is always like this first walk outside with a toddler: You never know where you end up: manic laughter at the playground or existential crying in the supermarket.” Regarding his ongoing fascination with machines as instruments, Moritz muses, “When I was younger, I played in a punk rock band, but at some point, I got really annoyed by my fellow musicians, so I swore to myself that I would never play with human musicians again. Jokes aside, I think robotics is a wonderful tool to give a body back to the normally electronically generated sound of techno. The main reason why I’m using robotics as a musical instrument is that the computer is, in my opinion, not the best tool for creating electronic sounds.”
More about Moritz Simon Geist and “Don’t Look at Me” https://www.moritzsimongeist.com/dont-look-at-me https://cloud.moritzsimongeist.com/s/yp9ZYsieH8wwDPD

TED 2024 (Vancouver, BC, Canada)

Should you be considering a ticket purchase for the April 15 – 19, 2024 TED event in Vancouver, the cheap ($6250 [USD?]) seats are sold out. Tickets at the next level up are $12,500 and after that, they are $25,000. Should you have more money to burn, you are of course free to become a patron.

A look at the 2024 list of speakers will tell you it is an eclectic list with a significant proportion of speakers focused on the topic of artificial intelligence/robotics.

The three speakers being highlighted here are not focused on artificial intelligence/robotics and have nothing in common with each other (topic wise).

First up, Bill Ackman, a very, very wealthy man, has a messy backstory. Here’s the short description followed by the long one,

Bill Ackman
Founder and CEO, Pershing Square Capital Management
TALK TOPIC
The activist investor playbook (in conversation with Alison Taylor)
Bill Ackman is founder and CEO of the hedge fund Pershing Square Capital Management and a storied activist investor. He is the chairman of Howard Hughes Holdings, a real estate development and management company based in Texas, and a member of the board of Universal Music Group. He is also the co-trustee of The Pershing Square Foundation, a family foundation supporting those tackling important social issues worldwide. At TED2024, Ackman will be interviewed by business professor Alison Taylor.

Mr. Ackman is not entirely self-made, from his Wikipedia entry, Note: Links have been removed,

…
Ackman was raised in Chappaqua, New York, the son of Ronnie I. (née Posner) and Lawrence David Ackman, the former chairman of a New York real estate financing firm, Ackman-Ziff Real Estate Group. [emphases mine] ^[10][11][12] He is of Ashkenazi Jewish descent.^[13][14][15] In 1988, he received a Bachelor of Arts degree magna cum laude in social studies from Harvard College. His thesis was titled Scaling the Ivy Wall: The Jewish and Asian American Experience in Harvard Admissions.^[16] In 1992, he received a Master of Business Administration degree from Harvard Business School.^[17]

As for the messiness, there’s this from from his Wikipedia entry, Note 1: Links have been removed, Note 2: All emphases are mine,

…
In October 2023, following the onset of the 2023 Israel–Hamas war after the October 7 attack, several Harvard undergraduate student groups signed a letter condemning the Israeli state. The statement held the “Israeli regime entirely responsible for all unfolding violence,” declared that millions of Palestinians in Gaza have been “forced to live in an open-air prison,” and called on Harvard to “take action to stop the ongoing annihilation of Palestinians.”
In response, Ackman called for the publication of the names of all students involved in signing the letter so that he could ensure his company and others do not “inadvertently hire” any of the signatories. Ackman posted, “One should not be able to hide behind a corporate shield when issuing statements supporting the actions of terrorists,” and the names “should be made public so their views are publicly known”.^[83] Ackman’s stance was supported by other CEOs such as Jonathan Neman, David Duel and Jake Wurzak.^[84] Former Harvard president Lawrence Summers, though agreeing with Ackman on the need to look at employees’ political views, called Ackman’s request for a list of names “the stuff of Joe McCarthy”.^[85]
In November 2023, Ackman defended Elon Musk after the latter expressed agreement with a user who asserted that “Jewish communities” supported “hordes of minorities flooding their country” and pushed “dialectical hatred against whites”, describing it as “shoot from the hip commentary”.^[86][87]
Ackman also engaged in a campaign to remove Claudine Gay from her position as Harvard’s president. He argued that her response to antisemitism was insufficient and amplified allegations by conservative media that she engaged in plagiarism.^[88][89]
On January 3, 2024, Business Insider published an article alleging that Ackman’s wife, Neri Oxman*, plagiarized portions of her dissertation. A day after the article’s publication, Oxman apologized for plagiarizing portions of her dissertation.^[90][91] Ackman, in response to the article, pledged to conduct a plagiarism review of all MIT [Massachusetts Institute of Technology] faculty, including MIT’s president, Sally Kornbluth, who, alongside Gay, attended a congressional hearing on antisemitism in higher education.^[90]
…
In 2018, Ackman became engaged to Neri Oxman.^[94] In January 2019, Oxman and Ackman married at the Central Synagogue in Manhattan,^[13] and they had their first child together in spring 2019.^[95] In August 2019, Ackman wrote to MIT Media Lab director Joi Ito to discourage him from mentioning Oxman when discussing convicted sex offender Jeffrey Epstein, who had donated $125,000 to Oxman’s lab.^[96]
…

*There are more complications where Neri Oxman is concerned. She is an Israeli-American who came to the US in 2005 where she commenced PhD studies at MIT. After graduation she became a professor at MIT, a position she has left to found Oxman Architects in 2020. Despite the company name, the business seems more focused on art installations and experimental work. (sourced from Oxman’s Wikipedia entry)*

I wonder how Mr. Ackman characterizes the difference between activism and actions, which result in the destruction of other people’s careers because you disagree with them.

Ackman’s interviewer, Alison Taylor is an interesting choice given that she is a business professor at New York University’s Stern School of Business and author of a February 6, 2024 article (Corporate Advocacy in a Time of Social Outrage; Businesses can’t weigh in on every issue that employees care about. But they can create a culture of open dialogue and ethical transparency [emphasis mine]) for the Harvard Business Review, The article is excerpted from Taylor’s book, “Higher Ground: How Business Can Do the Right Thing in a Turbulent World,” published by Harvard Business Review Press, Feb. 13 2024.

This talk looks like an attempt to rehabilitate Mr. Ackman’s reputation while giving Ms. Taylor publicity for her newly published book in an environment where neither is likely to be strongly challenged.

The two speakers I’m most excited about are Tammy Ma, fusion physicist, and Brian Stokes Mitchell, actor and singer.

As there is a local company known as General Fusion, the topic of fusion energy has been covered here a number of times including a relevant to Ms. Ma’s TED appearance December 13, 2022 posting, “US announces fusion energy breakthrough.”

From the 2024 list of TED speakers,

Tammy Ma
Fusion physicist
TALK TOPIC
The future of fusion
LinkedIn
Tammy Ma is the lead for the Inertial Fusion Energy Initiative at Lawrence Livermore National Laboratory, where she creates miniature stars in order to develop ways to harness their power as a clean, limitless energy source for the future. She was a member of the team at the National Ignition Facility that achieved fusion ignition in December 2022 — a reaction that, for the first time in history, released more energy than it consumed. [emphasis mine] A fellow of the American Physical Society, she serves on the Fusion Energy Sciences Advisory Committee, advising the US Department of Energy’s Office of Science on issues related to fusion energy and plasma research.

Now for someone completely different, Brian Stokes Mitchell, from the 2024 list of TED speakers,

Brian Stokes Mitchell
Actor, singer
TALK TOPIC
A celebration of spectacle (with Lear DeBessonet [award-winning Broadway director who specializes in creating large-scale performances])
brianstokes.com
YouTube:
@brianstokesmitchell7280
Brian Stokes Mitchell is a Tony-winning actor, singer and music producer. A veteran of 11 Broadway shows and a member of the Theatre Hall of Fame, he has performed iconic roles including Frasier’s snarky upstairs neighbor Cam, Hillary’s bungie-jumping boyfriend on the Fresh Prince of Bel-Air, The Prince of Egypt (singing “Through Heaven’s Eyes”) and, most recently, Stanley Townsend in the 2024 feature film Shirley with Regina King. He has performed twice at the White House, serves on the board of Americans for the Arts and is one of the founding members of Black Theatre United.

Stokes Mitchell performed at the Library of Congress Gershwin Prize for Popular Song ceremony in 2017 when Tony Bennett was the honoree. The performances were top notch but something happened when Stokes Mitchell took the stage for his first number. The audience was electrified as was every performer who came after him, some of them giving their second performance of the evening. There is no guarantee that Mr. Stoke Mitchell can do that at his 2024 TED talk but that is the blessing and the curse of live performances.

Enjoy!

Chatbot with expertise in nanomaterials

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This December 1, 2023 news item on phys.org starts with a story,

A researcher has just finished writing a scientific paper. She knows her work could benefit from another perspective. Did she overlook something? Or perhaps there’s an application of her research she hadn’t thought of. A second set of eyes would be great, but even the friendliest of collaborators might not be able to spare the time to read all the required background publications to catch up.
Kevin Yager—leader of the electronic nanomaterials group at the Center for Functional Nanomaterials (CFN), a U.S. Department of Energy (DOE) Office of Science User Facility at DOE’s Brookhaven National Laboratory—has imagined how recent advances in artificial intelligence (AI) and machine learning (ML) could aid scientific brainstorming and ideation. To accomplish this, he has developed a chatbot with knowledge in the kinds of science he’s been engaged in.
…

A December 1, 2023 DOE/Brookhaven National Laboratory news release by Denise Yazak (also on EurekAlert), which originated the news item, describes a research project with a chatbot that has nanomaterial-specific knowledge, Note: Links have been removed,

Rapid advances in AI and ML have given way to programs that can generate creative text and useful software code. These general-purpose chatbots have recently captured the public imagination. Existing chatbots—based on large, diverse language models—lack detailed knowledge of scientific sub-domains. By leveraging a document-retrieval method, Yager’s bot is knowledgeable in areas of nanomaterial science that other bots are not. The details of this project and how other scientists can leverage this AI colleague for their own work have recently been published in Digital Discovery.
Rise of the Robots
“CFN has been looking into new ways to leverage AI/ML to accelerate nanomaterial discovery for a long time. Currently, it’s helping us quickly identify, catalog, and choose samples, automate experiments, control equipment, and discover new materials. Esther Tsai, a scientist in the electronic nanomaterials group at CFN, is developing an AI companion to help speed up materials research experiments at the National Synchrotron Light Source II (NSLS-II).” NSLS-II is another DOE Office of Science User Facility at Brookhaven Lab.
At CFN, there has been a lot of work on AI/ML that can help drive experiments through the use of automation, controls, robotics, and analysis, but having a program that was adept with scientific text was something that researchers hadn’t explored as deeply. Being able to quickly document, understand, and convey information about an experiment can help in a number of ways—from breaking down language barriers to saving time by summarizing larger pieces of work.
Watching Your Language
To build a specialized chatbot, the program required domain-specific text—language taken from areas the bot is intended to focus on. In this case, the text is scientific publications. Domain-specific text helps the AI model understand new terminology and definitions and introduces it to frontier scientific concepts. Most importantly, this curated set of documents enables the AI model to ground its reasoning using trusted facts.
To emulate natural human language, AI models are trained on existing text, enabling them to learn the structure of language, memorize various facts, and develop a primitive sort of reasoning. Rather than laboriously retrain the AI model on nanoscience text, Yager gave it the ability to look up relevant information in a curated set of publications. Providing it with a library of relevant data was only half of the battle. To use this text accurately and effectively, the bot would need a way to decipher the correct context.
“A challenge that’s common with language models is that sometimes they ‘hallucinate’ plausible sounding but untrue things,” explained Yager. “This has been a core issue to resolve for a chatbot used in research as opposed to one doing something like writing poetry. We don’t want it to fabricate facts or citations. This needed to be addressed. The solution for this was something we call ‘embedding,’ a way of categorizing and linking information quickly behind the scenes.”
Embedding is a process that transforms words and phrases into numerical values. The resulting “embedding vector” quantifies the meaning of the text. When a user asks the chatbot a question, it’s also sent to the ML embedding model to calculate its vector value. This vector is used to search through a pre-computed database of text chunks from scientific papers that were similarly embedded. The bot then uses text snippets it finds that are semantically related to the question to get a more complete understanding of the context.
The user’s query and the text snippets are combined into a “prompt” that is sent to a large language model, an expansive program that creates text modeled on natural human language, that generates the final response. The embedding ensures that the text being pulled is relevant in the context of the user’s question. By providing text chunks from the body of trusted documents, the chatbot generates answers that are factual and sourced.
“The program needs to be like a reference librarian,” said Yager. “It needs to heavily rely on the documents to provide sourced answers. It needs to be able to accurately interpret what people are asking and be able to effectively piece together the context of those questions to retrieve the most relevant information. While the responses may not be perfect yet, it’s already able to answer challenging questions and trigger some interesting thoughts while planning new projects and research.”
Bots Empowering Humans
CFN is developing AI/ML systems as tools that can liberate human researchers to work on more challenging and interesting problems and to get more out of their limited time while computers automate repetitive tasks in the background. There are still many unknowns about this new way of working, but these questions are the start of important discussions scientists are having right now to ensure AI/ML use is safe and ethical.
“There are a number of tasks that a domain-specific chatbot like this could clear from a scientist’s workload. Classifying and organizing documents, summarizing publications, pointing out relevant info, and getting up to speed in a new topical area are just a few potential applications,” remarked Yager. “I’m excited to see where all of this will go, though. We never could have imagined where we are now three years ago, and I’m looking forward to where we’ll be three years from now.”
For researchers interested in trying this software out for themselves, the source code for CFN’s chatbot and associated tools can be found in this github repository.
Brookhaven National Laboratory is supported by the Office of Science of the U.S. Department of Energy. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit science.energy.gov.

Here’s a link to and a citation for the paper,

Domain-specific chatbots for science using embeddings by Kevin G. Yager.
Digital Discovery, 2023,2, 1850-1861 DOI: https://doi.org/10.1039/D3DD00112A
First published 10 Oct 2023

This paper appears to be open access.

Living technology possibilities

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Before launching into the possibilities, here are two descriptions of ‘living technology’ from the European Centre for Living Technology’s (ECLT) homepage,

Goals
Promote, carry out and coordinate research activities and the diffusion of scientific results in the field of living technology. The scientific areas for living technology are the nano-bio-technologies, self-organizing and evolving information and production technologies, and adaptive complex systems.
…
History
Founded in 2004 the European Centre for Living Technology is an international and interdisciplinary research centre established as an inter-university consortium, currently involving 18 European and extra-European institutional affiliates.
The Centre is devoted to the study of technologies that exhibit life-like properties including self-organization, adaptability and the capacity to evolve.
…

Despite the reference to “nano-bio-technologies,” this October 11, 2023 news item on ScienceDaily focuses on microscale living technology,

It is noIn a recent article in the high-profile journal “Advanced Materials,” researchers in Chemnitz show just how close and necessary the transition to sustainable living technology is, based on the morphogenesis of self-assembling microelectronic modules, strengthening the recent membership of Chemnitz University of Technology with the European Centre for Living Technology (ECLT) in Venice.
…

An October 11, 2023 Chemnitz University of Technology (Technische Universität Chemnitz; TU Chemnitz) press release (also on EurekAlert), which originated the news item, delves further into the topic, Note: Links have been removed,

It is now apparent that the mass-produced artefacts of technology in our increasingly densely populated world – whether electronic devices, cars, batteries, phones, household appliances, or industrial robots – are increasingly at odds with the sustainable bounded ecosystems achieved by living organisms based on cells over millions of years. Cells provide organisms with soft and sustainable environmental interactions with complete recycling of material components, except in a few notable cases like the creation of oxygen in the atmosphere, and of the fossil fuel reserves of oil and coal (as a result of missing biocatalysts). However, the fantastic information content of biological cells (gigabits of information in DNA alone) and the complexities of protein biochemistry for metabolism seem to place a cellular approach well beyond the current capabilities of technology, and prevent the development of intrinsically sustainable technology.
SMARTLETs: tiny shape-changing modules that collectively self-organize to larger more complex systems
A recent perspective review published in the very high impact journal Advanced Materials this month [October 2023] by researchers at the Research Center for Materials, Architectures and Integration of Nanomembranes (MAIN) of Chemnitz University of Technology, shows how a novel form of high-information-content Living Technology is now within reach, based on microrobotic electronic modules called SMARTLETs, which will soon be capable of self-assembling into complex artificial organisms. The research belongs to the new field of Microelectronic Morphogenesis, the creation of form under microelectronic control, and builds on work over the previous years at Chemnitz University of Technology to construct self-folding and self-locomoting thin film electronic modules, now carrying tiny silicon chiplets between the folds, for a massive increase in information processing capabilities. Sufficient information can now be stored in each module to encode not only complex functions but fabrication recipes (electronic genomes) for clean rooms to allow the modules to be copied and evolved like cells, but safely because of the gating of reproduction through human operated clean room facilities.
Electrical self-awareness during self-assembly
In addition, the chiplets can provide neuromorphic learning capabilities allowing them to improve performance during operation. A further key feature of the specific self-assembly of these modules, based on matching physical bar codes, is that electrical and fluidic connections can be achieved between modules. These can then be employed, to make the electronic chiplets on board “aware” of the state of assembly, and of potential errors, allowing them to direct repair, correct mis-assembly, induce disassembly and form collective functions spanning many modules. Such functions include extended communication (antennae), power harvesting and redistribution, remote sensing, material redistribution etc.
So why is this technology vital for sustainability?
The complete digital fab description for modules, for which actually only a limited number of types are required even for complex organisms, allows their material content, responsible originator and environmentally relevant exposure all to be read out. Prof. Dagmar Nuissl-Gesmann from the Law Department at Chemnitz University of Technology observes that “this fine-grained documentation of responsibility intrinsic down to microscopic scales will be a game changer in allowing legal assignment of environmental and social responsibility for our technical artefacts”.
Furthermore, the self-locomotion and self-assembly-disassembly capabilities allows the modules to self-sort for recycling. Modules can be regained, reused, reconfigured, and redeployed in different artificial organisms. If they are damaged, then their limited and documented types facilitate efficient custom recycling of materials with established and optimized protocols for these sorted and now identical entities. These capabilities complement the other more obvious advantages in terms of design development and reuse in this novel reconfigurable media. As Prof. Marlen Arnold, an expert in Sustainability of the Faculty of Economics and Business Administration observes, “Even at high volumes of deployment use, these properties could provide this technology with a hitherto unprecedented level of sustainability which would set the bar for future technologies to share our planet safely with us.”
Contribution to European Living Technology
This research is a first contribution of MAIN/Chemnitz University of Technology, as a new member of the European Centre for Living Technology ECLT, based in Venice,” says Prof. Oliver G. Schmidt, Scientific Director of the Research Center MAIN and adds that “It’s fantastic to see that our deep collaboration with ECLT is paying off so quickly with immediate transdisciplinary benefit for several scientific communities.” “Theoretical research at the ECLT has been urgently in need of novel technology systems able to implement the core properties of living systems.” comments Prof. John McCaskill, coauthor of the paper, and a grounding director of the ECLT in 2004.

Here’s a link to and a citation for the researchers’ perspective paper,

Microelectronic Morphogenesis: Smart Materials with Electronics Assembling into Artificial Organisms by John S. McCaskill, Daniil Karnaushenko, Minshen Zhu, Oliver G. Schmidt. Advanced Materials DOI: https://doi.org/10.1002/adma.202306344 First published: 09 October 2023

This paper is open access.

XoMotion, an exoskeleton developed in Canada causes commotion

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I first stumbled across these researchers in 2016 when their project was known as “Wearable Lower Limb Anthropomorphic Exoskeleton (WLLAE).” In my January 20, 2016 posting, “#BCTECH: being at the Summit (Jan. 18-19, 2016),” an event put on by the province of British Columbia (BC, Canada) and the BC Innovation Council (BCIC), I visited a number of booths and talks at the #BC TECH Summit and had this to say about WLLAE,

“The Wearable Lower Limb Anthropomorphic Exoskeleton (WLLAE) – a lightweight, battery-operated and ergonomic robotic system to help those with mobility issues improve their lives. The exoskeleton features joints and links that correspond to those of a human body and sync with motion. SFU has designed, manufactured and tested a proof-of-concept prototype and the current version can mimic all the motions of hip joints.” The researchers (Siamak Arzanpour and Edward Park) pointed out that the ability to mimic all the motions of the hip is a big difference between their system and others which only allow the leg to move forward or back. They rushed the last couple of months to get this system ready for the Summit. In fact, they received their patent for the system the night before (Jan. 17, 2016) the Summit opened.
…
Unfortunately, there aren’t any pictures of WLLAE yet and the proof-of-concept version may differ significantly from the final version. This system could be used to help people regain movement (paralysis/frail seniors) and I believe there’s a possibility it could be used to enhance human performance (soldiers/athletes). The researchers still have some significant hoops to jump before getting to the human clinical trial stage. They need to refine their apparatus, ensure that it can be safely operated, and further develop the interface between human and machine. I believe WLLAE is considered a neuroprosthetic device. While it’s not a fake leg or arm, it enables movement (prosthetic) and it operates on brain waves (neuro). It’s a very exciting area of research, consequently, there’s a lot of international competition. [ETA January 3, 2024: I’m pretty sure I got the neuroprosthetic part wrong]

Time moved on and there was a name change and then there was this November 10, 2023 article by Jeremy Hainsworth for the Vancouver is Awesome website,

Vancouver-based fashion designer Chloe Angus thought she’d be in a wheelchair for the rest of her life after being diagnosed with an inoperable benign tumour in her spinal cord in 2015, resulting in permanent loss of mobility in her legs.
Now, however, she’s been using a state-of-the-art robotic exoskeleton known as XoMotion that can help physically disabled people self-balance, walk, sidestep, climb stairs and crouch.
“The first time I walked with the exoskeleton was a jaw-dropping experience,” said Angus. “After all these years, the exoskeleton let me stand up and walk on my own without falling. I felt like myself again.”
She added the exoskeleton has the potential to completely change the world for people with motion disabilities.
XoMotion is the result of a decade of research and the product of a Simon Fraser University spinoff company, Human in Motion Robotics (HMR) Inc. It’s the brainchild of professors Siamak Arzanpour and Edward Park.
Arzanpour and Park, both researchers in the Burnaby-based university’s School of Mechatronic Systems Engineering, began work on the device in 2014. They had a vision to enhance exoskeleton technology and empower individuals with mobility challenges to have more options for movement.
“We felt that there was an immediate need to help people with motion disabilities to walk again, with a full range of motion. At the time, exoskeletons could only walk forward. That was the only motion possible,” Arzanpour said.
…

A November 15, 2023 article (with an embedded video) by Amy Judd & Alissa Thibault for Global News (television) highlights Alexander’s story,

…
SFU professors Siamak Arzanpour and Edward Park wanted to help people with motion disabilities to walk freely, naturally and independently.
The exoskeleton [XoMotion] is now the most advanced of its kind in the world.
Chloe Angus, who lost her mobility in her legs in 2015, now works for the team.
She said the exoskeleton makes her feel like herself again.
…
She was diagnosed with an inoperable benign tumor in her spinal cord in 2015 which resulted in a sudden and permanent loss of mobility in her legs. At the time, doctors told Angus that she would need a wheelchair to move for the rest of her life.
Now she is part of the project and defying all odds.
“After all these years, the exoskeleton let me stand up and walk on my own without falling. I felt like myself again.”
…

There’s a bit more information in the November 8, 2023 Simon Fraser University (SFU) news release (which has the same embedded video as the Global News article) by Ray Sharma,

The state-of-the-art robotic exoskeleton known as XoMotion is the result of a decade of research and the product of an SFU spin off company, Human in Motion Robotics (HMR) Inc. The company has recently garnered millions in investment, an overseas partnership and a suite of new offices in Vancouver.
XoMotion allows individuals with mobility challenges to stand up and walk on their own, without additional support. When in use, XoMotion maintains its stability and simultaneously encompasses all the ranges of motion and degrees of freedom needed for users to self-balance, walk, sidestep, climb stairs, crouch, and more.
Sensors within the lower-limb exoskeleton mimic the human body’s sense of logic to identify structures along the path, and in-turn, generate a fully balanced motion.
SFU professors Siamak Arzanpour and Edward Park, both researchers in the School of Mechatronic Systems Engineering, began work on the device in 2014 with a vision to enhance exoskeleton technology and empower individuals with mobility challenges to have more options for movement.
“We felt that there was an immediate need to help people with motion disabilities to walk again, with a full range of motion. At the time, exoskeletons could only walk forward. That was the only motion possible,” says Arzanpour.
The SFU professors, who first met in 2001 as graduate students at the University of Toronto, co-founded HMR in 2016, bringing together a group of students, end-users, therapists, and organizations to build upon the exoskeleton. Currently, 70 per cent of HMR employees are SFU graduates.
…
In recent years, HMR has garnered multiple streams of investment, including a contract with Innovative Solutions Canada, and $10 million in funding during their Series A round in May, including an $8 million investment and strategic partnership from Beno TNR, a prominent Korean technology investment firm.
…

I decided to bring the embedded video here, it runs a little over 2 mins.,

You can find the Human in Robotics (HMR) website here.

FrogHeart’s 2023 comes to an end as 2024 comes into view

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My personal theme for this last year (2023) and for the coming year was and is: catching up. On the plus side, my 2023 backlog (roughly six months) to be published was whittled down considerably. On the minus side, I start 2024 with a backlog of two to three months.

2023 on this blog had a lot in common with 2022 (see my December 31, 2022 posting), which may be due to what’s going on in the world of emerging science and technology or to my personal interests or possibly a bit of both. On to 2023 and a further blurring of boundaries:

Energy, computing and the environment

The argument against paper is that it uses up resources, it’s polluting, it’s affecting the environment, etc. Somehow the part where electricity which underpins so much of our ‘smart’ society does the same thing is left out of the discussion.

Neuromorphic (brainlike) computing and lower energy

Before launching into the stories about lowering energy usage, here’s an October 16, 2023 posting “The cost of building ChatGPT” that gives you some idea of the consequences of our insatiable desire for more computing and more ‘smart’ devices,

…
In its latest environmental report, Microsoft disclosed that its global water consumption spiked 34% from 2021 to 2022 (to nearly 1.7 billion gallons , or more than 2,500 Olympic-sized swimming pools), a sharp increase compared to previous years that outside researchers tie to its AI research. [emphases mine]
“It’s fair to say the majority of the growth is due to AI,” including “its heavy investment in generative AI and partnership with OpenAI,” said Shaolei Ren, [emphasis mine] a researcher at the University of California, Riverside who has been trying to calculate the environmental impact of generative AI products such as ChatGPT.
…
Why it matters: Microsoft’s five WDM [West Des Moines in Iowa] data centers — the “epicenter for advancing AI” — represent more than $5 billion in investments in the last 15 years.
Yes, but: They consumed as much as 11.5 million gallons of water a month for cooling, or about 6% of WDM’s total usage during peak summer usage during the last two years, according to information from West Des Moines Water Works.

The focus is AI but it doesn’t take long to realize that all computing has energy and environmental costs. I have more about Ren’s work and about water shortages in the “The cost of building ChatGPT” posting.

This next posting would usually be included with my other art/sci postings but it touches on the issues. My October 13, 2023 posting about Toronto’s Art/Sci Salon events, in particular, there’s the Streaming Carbon Footprint event (just scroll down to the appropriate subhead). For the interested, I also found this 2022 paper “The Carbon Footprint of Streaming Media:; Problems, Calculations, Solutions” co-authored by one of the artist/researchers (Laura U. Marks, philosopher and scholar of new media and film at Simon Fraser University) who presented at the Toronto event.

I’m late to the party; Thomas Daigle posted a January 2, 2020 article about energy use and our appetite for computing and ‘smart’ devices for the Canadian Broadcasting Corporation’s online news,

For those of us binge-watching TV shows, installing new smartphone apps or sharing family photos on social media over the holidays, it may seem like an abstract predicament.
The gigabytes of data we’re using — although invisible — come at a significant cost to the environment. Some experts say it rivals that of the airline industry.
And as more smart devices rely on data to operate (think internet-connected refrigerators or self-driving cars), their electricity demands are set to skyrocket.
“We are using an immense amount of energy to drive this data revolution,” said Jane Kearns, an environment and technology expert at MaRS Discovery District, an innovation hub in Toronto.
“It has real implications for our climate.”
…

Some good news

Researchers are working on ways to lower the energy and environmental costs, here’s a sampling of 2023 posts with an emphasis on brainlike computing that attest to it,

January 30, 2023 posting: “Synaptic transistors for brainlike computers based on (more environmentally friendly) graphene“
January 31, 2023 posting, “New chip for neuromorphic computing runs at a fraction of the energy of today’s systems“
June 15, 2023 posting “Combining silicon with metal oxide memristors to create powerful, low-energy intensive chips enabling AI in portable devices“
July 26, 2023 posting (I was late, the news was from March 2023), “Memristors based on halide perovskite nanocrystals are more powerful and easier to manufacture“
October 12, 2023 posting, “IBM’s neuromorphic chip, a prototype and more“
October 17, 2023 posting, “100-fold increase in AI energy efficiency“
November 24, 2023 posting, “NorthPole: a brain-inspired chip design for saving energy“

If there’s an industry that can make neuromorphic computing and energy savings sexy, it’s the automotive indusry,

February 23, 2023, “Neuromorphic (brainlike) computing and your car (a Mercedes Benz Vision AVTR concept car)“

On the energy front,

October 11, 2023 posting, “General Fusion: update to October 10, 2023“

Most people are familiar with nuclear fission and some its attendant issues. There is an alternative nuclear energy, fusion, which is considered ‘green’ or greener anyway. General Fusion is a local (Vancouver area) company focused on developing fusion energy, alongside competitors from all over the planet.

Part of what makes fusion energy attractive is that salt water or sea water can be used in its production and, according to that December posting, there are other applications for salt water power,

December 13, 2023 posting, “Powered with salt water“

More encouraging developments in environmental science

Again, this is a selection. You’ll find a number of nano cellulose research projects and a couple of seaweed projects (seaweed research seems to be of increasing interest).

March 6, 2023, “Seaweed battery“
March 13, 2023 posting, “Cellulose nanofibers as an alternative material for petroleum-based plastics?“
March 16, 2023 posting, “Plant fibers (nanocellulose) for more sustainable devices“
June 8, 2023 posting, “Fairy-like robot powered by wind and light“
June 20, 2023 posting, “Enabling a transparent wood battery that stores heat and regulates indoor temperature with lemons and coconuts“
June 27, 2023 posting, “Biobattery with a 100-year shelf life“
July 6, 2023 posting, “Greener cellulose-based products“
July 26, 2023 posting, “Biodegradable electronics: a seaweed biosensor“
July 25, 2023 posting, “A structural colour solution for energy-saving paint (thank the butterflies)“
August 3, 2023 posting, “Remove 80 percent of dye pollutants from wastewater with wood nanocrystals“
October 26, 2023 posting, “Using insect corpses to create biodegradable plastics“
November 8, 2023 posting, “Nanocellulose and food waste, an Australian perspective“
December 4, 2023, “The University of British Columbia and its November 28, 2023 Great UBC Bug Bake Off“
December 5, 2023 posting, “AI for salmon recovery“

All by myself (neuromorphic engineering)

Neuromorphic computing is a subset of neuromorphic engineering and I stumbled across an article that outlines the similarities and differences. My ‘summary’ of the main points and a link to the original article can be found here,

June 23, 2023 posting, “Neuromorphic engineering: an overview“

Oops! I did it again. More AI panic

I included an overview of the various ‘recent’ panics (in my May 25, 2023 posting below) along with a few other posts about concerning developments but it’s not all doom and gloom..

May 1, 2023 posting, “Canada, AI regulation, and the second reading of the Digital Charter Implementation Act, 2022 (Bill C-27)“
May 25, 2023 posting, “Non-human authors (ChatGPT or others) of scientific and medical studies and the latest AI panic!!!“
July 21, 2023 posting, “Lero (Science Foundation Ireland Research Centre for Software) researchers need to know (survey): Will artificial intelligence (AI) end civilization?“
September 6, 2023 posting, “AI art threatens your humanity according to a study“
October 19, 2023 posting, “AI ‘author’ steals another author’s identity“
November 14, 2023 posting, “AI incites hiring of poets“
November 28, 2023 posting, “An artificial, multisensory integrated neuron makes AI (artificial intelligence) smarter“
December 7, 2023 posting, “AI-led corporate entities as a new species of legal subject“

Governments have realized that regulation might be a good idea. The European Union has a n AI act, the UK held an AI Safety Summit in November 2023, the US has been discussing AI regulation with its various hearings, and there’s impending legislation in Canada (see professor and lawyer Michael Geist’s blog for more).

A long time coming, a nanomedicine comeuppance

Paolo Macchiarini is now infamous for his untested, dangerous approach to medicine. Like a lot of people, I was fooled too as you can see in my August 2, 2011 posting, “Body parts nano style,”

In early July 2011, there were reports of a new kind of transplant involving a body part made of a biocomposite. Andemariam Teklesenbet Beyene underwent a trachea transplant that required an artificial windpipe crafted by UK experts then flown to Sweden where Beyene’s stem cells were used to coat the windpipe before being transplanted into his body.
It is an extraordinary story not least because Beyene, a patient in a Swedish hospital planning to return to Eritrea after his PhD studies in Iceland, illustrates the international cooperation that made the transplant possible.
The scaffolding material for the artificial windpipe was developed by Professor Alex Seifalian at the University College London in a landmark piece of nanotechnology-enabled tissue engineering. …

Five years later I stumbled across problems with Macchiarini’s work as outlined in my April 19, 2016 posting, “Macchiarini controversy and synthetic trachea transplants (part 1 of 2)” and my other April 19, 2016 posting, “Macchiarini controversy and synthetic trachea transplants (part 2 of 2)“.

This year, Gretchen Vogel (whose work was featured in my 2016 posts) has written a June 21, 2023 update about the Macchiarini affair for Science magazine, Note: Links have been removed,

Surgeon Paolo Macchiarini, who was once hailed as a pioneer of stem cell medicine, was found guilty of gross assault against three of his patients today and sentenced to 2 years and 6 months in prison by an appeals court in Stockholm. The ruling comes a year after a Swedish district court found Macchiarini guilty of bodily harm in two of the cases and gave him a suspended sentence. After both the prosecution and Macchiarini appealed that ruling, the Svea Court of Appeal heard the case in April and May. Today’s ruling from the five-judge panel is largely a win for the prosecution—it had asked for a 5-year sentence whereas Macchiarini’s lawyer urged the appeals court to acquit him of all charges.
Macchiarini performed experimental surgeries on the three patients in 2011 and 2012 while working at the renowned Karolinska Institute. He implanted synthetic windpipes seeded with stem cells from the patients’ own bone marrow, with the hope the cells would multiply over time and provide an enduring replacement. All three patients died when the implants failed. One patient died suddenly when the implant caused massive bleeding just 4 months after it was implanted; the two others survived for 2.5 and nearly 5 years, respectively, but suffered painful and debilitating complications before their deaths.
In the ruling released today, the appeals judges disagreed with the district court’s decision that the first two patients were treated under “emergency” conditions. Both patients could have survived for a significant length of time without the surgeries, they said. The third case was an “emergency,” the court ruled, but the treatment was still indefensible because by then Macchiarini was well aware of the problems with the technique. (One patient had already died and the other had suffered severe complications.)
…

A fictionalized tv series ( part of the Dr. Death anthology series) based on Macchiarini’s deceptions and a Dr. Death documentary are being broadcast/streamed in the US during January 2024. These come on the heels of a November 2023 Macchiarini documentary also broadcast/streamed on US television.

Dr. Death (anthology), based on the previews I’ve seen, is heavily US-centric, which is to be expected since Adam Ciralsky is involved in the production. Ciralsky wrote an exposé about Macchiarini for Vanity Fair published in 2016 (also featured in my 2016 postings). From a December 20, 2023 article by Julie Miller for Vanity Fair, Note: A link has been removed,

Seven years ago [2016], world-renowned surgeon Paolo Macchiarini was the subject of an ongoing Vanity Fair investigation. He had seduced award-winning NBC producer Benita Alexander while she was making a special about him, proposed, and promised her a wedding officiated by Pope Francis and attended by political A-listers. It was only after her designer wedding gown was made that Alexander learned Macchiarini was still married to his wife, and seemingly had no association with the famous names on their guest list.
Vanity Fair contributor Adam Ciralsky was in the midst of reporting the story for this magazine in the fall of 2015 when he turned to Dr. Ronald Schouten, a Harvard psychiatry professor. Ciralsky sought expert insight into the kind of fabulist who would invent and engage in such an audacious lie.
“I laid out the story to him, and he said, ‘Anybody who does this in their private life engages in the same conduct in their professional life,” recalls Ciralsky, in a phone call with Vanity Fair. “I think you ought to take a hard look at his CVs.”
That was the turning point in the story for Ciralsky, a former CIA lawyer who soon learned that Macchiarini was more dangerous as a surgeon than a suitor. …

Here’s a link to Ciralsky’s original article, which I described this way, from my April 19, 2016 posting (part 2 of the Macchiarini controversy),

For some bizarre frosting on this disturbing cake (see part 1 of the Macchiarini controversy and synthetic trachea transplants for the medical science aspects), a January 5, 2016 Vanity Fair article by Adam Ciralsky documents Macchiarini’s courtship of an NBC ([US] National Broadcasting Corporation) news producer who was preparing a documentary about him and his work.
[from Ciralsky’s article]
“Macchiarini, 57, is a magnet for superlatives. He is commonly referred to as “world-renowned” and a “super-surgeon.” He is credited with medical miracles, including the world’s first synthetic organ transplant, which involved fashioning a trachea, or windpipe, out of plastic and then coating it with a patient’s own stem cells. That feat, in 2011, appeared to solve two of medicine’s more intractable problems—organ rejection and the lack of donor organs—and brought with it major media exposure for Macchiarini and his employer, Stockholm’s Karolinska Institute, home of the Nobel Prize in Physiology or Medicine. Macchiarini was now planning another first: a synthetic-trachea transplant on a child, a two-year-old Korean-Canadian girl named Hannah Warren, who had spent her entire life in a Seoul hospital. … “

Other players in the Macchiarini story

Pierre Delaere, a trachea expert and professor of head and neck surgery at KU Leuven (a university in Belgium) was one of the first to draw attention to Macchiarini’s dangerous and unethical practices. To give you an idea of how difficult it was to get attention for this issue, there’s a September 1, 2017 article by John Rasko and Carl Power for the Guardian illustrating the issue. Here’s what they had to say about Delaere and other early critics of the work, Note: Links have been removed,

…
Delaere was one of the earliest and harshest critics of Macchiarini’s engineered airways. Reports of their success always seemed like “hot air” to him. He could see no real evidence that the windpipe scaffolds were becoming living, functioning airways – in which case, they were destined to fail. The only question was how long it would take – weeks, months or a few years.
Delaere’s damning criticisms appeared in major medical journals, including the Lancet, but weren’t taken seriously by Karolinska’s leadership. Nor did they impress the institute’s ethics council when Delaere lodged a formal complaint. [emphases mine]
Support for Macchiarini remained strong, even as his patients began to die. In part, this is because the field of windpipe repair is a niche area. Few people at Karolinska, especially among those in power, knew enough about it to appreciate Delaere’s claims. Also, in such a highly competitive environment, people are keen to show allegiance to their superiors and wary of criticising them. The official report into the matter dubbed this the “bandwagon effect”.
With Macchiarini’s exploits endorsed by management and breathlessly reported in the media, it was all too easy to jump on that bandwagon.
And difficult to jump off. In early 2014, four Karolinska doctors defied the reigning culture of silence [emphasis mine] by complaining about Macchiarini. In their view, he was grossly misrepresenting his results and the health of his patients. An independent investigator agreed. But the vice-chancellor of Karolinska Institute, Anders Hamsten, wasn’t bound by this judgement. He officially cleared Macchiarini of scientific misconduct, allowing merely that he’d sometimes acted “without due care”.
For their efforts, the whistleblowers were punished. [emphasis mine] When Macchiarini accused one of them, Karl-Henrik Grinnemo, of stealing his work in a grant application, Hamsten found him guilty. As Grinnemo recalls, it nearly destroyed his career: “I didn’t receive any new grants. No one wanted to collaborate with me. We were doing good research, but it didn’t matter … I thought I was going to lose my lab, my staff – everything.”
This went on for three years until, just recently [2017], Grinnemo was cleared of all wrongdoing.
…
It is fitting that Macchiarini’s career unravelled at the Karolinska Institute. As the home of the Nobel prize in physiology or medicine, one of its ambitions is to create scientific celebrities. Every year, it gives science a show-business makeover, picking out from the mass of medical researchers those individuals deserving of superstardom. The idea is that scientific progress is driven by the genius of a few.
It’s a problematic idea with unfortunate side effects. A genius is a revolutionary by definition, a risk-taker and a law-breaker. Wasn’t something of this idea behind the special treatment Karolinska gave Macchiarini? Surely, he got away with so much because he was considered an exception to the rules with more than a whiff of the Nobel about him. At any rate, some of his most powerful friends were themselves Nobel judges until, with his fall from grace, they fell too.
…

The September 1, 2017 article by Rasko and Power is worth the read if you have the interest and the time. And, Delaere has written up a comprehensive analysis, which includes basic information about tracheas and more, “The Biggest Lie in Medical History” 2020, PDF, 164 pp., Creative Commons Licence).

I also want to mention Leonid Schneider, science journalist and molecular cell biologist, whose work the Macchiarini scandal on his ‘For Better Science’ website was also featured in my 2016 pieces. Schneider’s site has a page titled, ‘Macchiarini’s trachea transplant patients: the full list‘ started in 2017 and which he continues to update with new information about the patients. The latest update was made on December 20, 2023.

Promising nanomedicine research but no promises and a caveat

Most of the research mentioned here is still in the laboratory. i don’t often come across work that has made its way to clinical trials since the focus of this blog is emerging science and technology,

January 25, 2023 posting, “Lab-made cartilage gel for stiff, achy knees“
May 9, 2023 posting, “Research on how the body will react to nanomedicines is inconsistent“
June 14, 2023 posting, “Biohybrid device (a new type of neural implant) could restore limb function“
July 14, 2023 posting, “Artificially-grown mini-brains (organoids)—without animal components— offer opportunities for neuroscience“
*July 17, 2023 posting, “Unveiling the Neurotechnology Landscape: Scientific Advancements, Innovations and Major Trends—a UNESCO report“
August 23, 2023 posting, “Nanoparticle drug delivery could reduce rejection rates for corneal transplants“
December 1, 2023 posting, “Scientists at Indian Institute of Science (IISc) created hybrid nanoparticles made of gold and copper sulfide that can kill cancer cells“
December 15, 2023 posting, “Reducing toxicity of Alzheimer’s proteins with graphene oxide“

*If you’re interested in the business of neurotechnology, the July 17, 2023 posting highlights a very good UNESCO report on the topic.

Funky music (sound and noise)

I have couple of stories about using sound for wound healing, bioinspiration for soundproofing applications, detecting seismic activity, more data sonification, etc.

January 5, 2023 posting, “Sound absorbing wallpaper inspired by moth wings“
January 23, 2023 posting, “Stifle the noise with seaweed“
January 25, 2023 posting, “Making longer lasting bandages with sound and bubbles“
February 13, 2023 posting, “It’s not just the sound, it’s the vibration too (a red-eyed treefrog calls for a mate)“
May 4, 2023 posting, “A fish baying at the moon?“
June 12, 2023 posting, “Music of the chemical elements“
June 14, 2023 posting, “The sound of dirt“
June 30, 2023 posting, “Sound waves for wearable patches that deliver drugs painlessly“
August 18, 2023 posting, “Animals: Art, Science and Sound at the British Library in London, UK until August 28, 2023 and Digital Storytelling until October 15, 2023“
December 12, 2023 posting, “Shape-changing speaker (aka acoustic swarms) for sound control“
December 18, 2023 posting, “When the rocks sing “I got rhythm”“
December 19,2023 posting, “The sounds of recent (December 2023) seismic activity in Iceland“

Same old, same old CRISPR

2023 was relatively quiet (no panics) where CRISPR developments are concerned but still quite active.

January 12, 203 posting, “What is CRISPRnano?“
March 8, 2023 posting, “Even a ‘good’ gene edit can go wrong“
August 2, 2023 posting, “Gene-edited food: better tasting and/or allergen-free?“
August 7, 2023 posting, “CRISPR-like system found in animals“
December 22, 2023 posting, “Gene editing to identify and change parts of chicken DNA and limit the spread of bird flu virus“

Art/Sci: a pretty active year

I didn’t realize how active the year was art/sciwise including events and other projects until I reviewed this year’s postings. This is a selection from 2023 but there’s a lot more on the blog, just use the search term, “art/sci,” or “art/science,” or “sciart.”

While I often feature events and projects from these groups (e.g., June 2, 2023 posting, “Metacreation Lab’s greatest hits of Summer 2023“), it’s possible for me to miss a few. So, you can check out Toronto’s Art/Sci Salon’s website (strong focus on visual art) and Simon Fraser University’s Metacreation Lab for Creative Artificial Intelligence website (strong focus on music).

My selection of this year’s postings is more heavily weighted to the ‘writing’ end of things.

February 10, 2023 posting, ““The Heart’s Knowledge: Science and Empathy in the Art of Dario Robleto” from Jan. 27 to July 9, 2023 at The Block Museum of Art (Northwestern University, Chicago, Illinois)“
March 28,k 2023 posting, ““Living in a Dream,” part of Cambridge Festival (on display March 31 and April 1, 2023 in the UK)“
April 4, 2023 posting, “Algorithmic haiku: Basho in the machine“
April 5, 2023 posting, “Perimeter Institute (PI) presents: The Jazz of Physics with Stephon Alexander“
May 15, 2023 posting, “‘Poetic meditation’ could enhance qualitative data analysis“
June 9, 2023 posting, “Mary Shelley’s Frankenstein, the scientist who may have helped inspire the story, and a poetry/science project“
June 22, 2023 posting, “Physics in James Joyce’s Ulysses and physics amongst the penguins“
August 2, 2023 posting, “Every thing old is new again: using fairy tales to communicate science (energy research)“
September 11, 2023 posting, “Leaning Out of Windows (LOoW): An Art and Physics Collaboration (2023 book) in Vancouver (Canada)“

Boundaries: life/nonlife

Last year I subtitled this section, ‘Aliens on earth: machinic biology and/or biological machinery?” Here’s this year’s selection,

February 9, 2023 posting, “Living photovoltaics with carbon nanotubes (CNTs)?“
March 17, 2023 posting, “Coelacanth (a living fish fossil) may provide clue to making artificial organs for transplantation“
March 23 2023 posting, “Transforming bacterial cells into living computers“
June 6 2023 posting, “In vitro biological neural networks (BNNs): review paper“
June 30, 2023 posting, “International conference “Living Machines” dedicated to technology inspired by nature in Genoa, Italy (July 10 – 13, 2023)“
July 13, 2023 posting, “Growing electrodes in your brain?“
October 3, 2023 posting, “The art and science of architecture that is ‘living-like’“
November 3, 2023 posting, “Nanoscale tattoos for individual cells“
December 6, 2023 posting, “They glow under stress: soft, living materials made with algae“

Canada’s 2023 budget … military

2023 featured an unusual budget where military expenditures were going to be increased, something which could have implications for our science and technology research.

April 24, 2023 posting, “The 2023 Canadian federal budget: science & technology of the military and cybersecurity and some closing comments (2 of 2)“

Then things changed as Murray Brewster’s November 21, 2023 article for the Canadian Broadcasting Corporation’s (CBC) news online website comments, Note: A link has been removed,

There was a revelatory moment on the weekend as Defence Minister Bill Blair attempted to bridge the gap between rhetoric and reality in the Liberal government’s spending plans for his department and the Canadian military.
Asked about an anticipated (and long overdue) update to the country’s defence policy (supposedly made urgent two years ago by Russia’s full-on invasion of Ukraine), Blair acknowledged that the reset is now being viewed through a fiscal lens.
“We said we’re going to bring forward a new defence policy update. We’ve been working through that,” Blair told CBC’s Rosemary Barton Live on Sunday.
“The current fiscal environment that the country faces itself does require (that) that defence policy update … recognize (the) fiscal challenges. And so it’ll be part of … our future budget processes.”
…
One policy goal of the existing defence plan, Strong, Secure and Engaged, was to require that the military be able to concurrently deliver “two sustained deployments of 500 [to] 1,500 personnel in two different theaters of operation, including one as a lead nation.”
In a footnote, the recent estimates said the Canadian military is “currently unable to conduct multiple operations concurrently per the requirements laid out in the 2017 Defence Policy. Readiness of CAF force elements has continued to decrease over the course of the last year, aggravated by decreasing number of personnel and issues with equipment and vehicles.”
Some analysts say they believe that even if the federal government hits its overall budget reduction targets, what has been taken away from defence — and what’s about to be taken away — won’t be coming back, the minister’s public assurances notwithstanding.
…

10 years: Graphene Flagship Project and Human Brain Project

“Graphene and Human Brain Project win biggest research award in history (& this is the 2000th post)” on January 28, 2013 was how I announced the results of what had been a a European Union (EU) competition that stretched out over several years and many stages as projects were evaluated and fell to the wayside or were allowed onto the next stage. The two finalists received €1B each to be paid out over ten years.
…

See the September 26, 2023 posting, “10 years of the European Union’s roll of the dice: €1B or 1billion euros each for the Human Brain Project (HBP) and the Graphene Flagship“

Future or not

As you can see, there was plenty of interesting stuff going on in 2023 but no watershed moments in the areas I follow. (Please do let me know in the Comments should you disagree with this or any other part of this posting.) Nanotechnology seems less and less an emerging science/technology in itself and more like a foundational element of our science and technology sectors. On that note, you may find my upcoming (in 2024) post about a report concerning the economic impact of its National Nanotechnology Initiative (NNI) from 2002 to 2022 of interest.

Following on the commercialization theme, I have noticed an increase of interest in commercializing brain and brainlike engineering technologies, as well as, more discussion about ethics.

Colonizing the brain?

UNESCO held events such as, this noted in my July 17, 2023 posting, “Unveiling the Neurotechnology Landscape: Scientific Advancements, Innovations and Major Trends—a UNESCO report” and this noted in my July 7, 2023 posting “Global dialogue on the ethics of neurotechnology on July 13, 2023 led by UNESCO.” An August 21, 2023 posting, “Ethical nanobiotechnology” adds to the discussion.

Meanwhile, Australia has been producing some very interesting mind/robot research, my June 13, 2023 posting, “Mind-controlled robots based on graphene: an Australian research story.” I have more of this kind of research (mind control or mind reading) from Australia to be published in early 2024. The Australians are not alone, there’s also this April 12, 2023 posting, “Mind-reading prosthetic limbs” from Germany.

My May 12, 2023 posting, “Virtual panel discussion: Canadian Strategies for Responsible Neurotechnology Innovation on May 16, 2023” shows Canada is entering the discussion. Unfortunately, the Canadian Science Policy Centre (CSPC), which held the event, has not posted a video online even though they have a youtube channel featuring other of their events.

As for neurmorphic engineering, China has produced a roadmap for its research in this area as noted in my March 20, 2023 posting, “A nontraditional artificial synaptic device and roadmap for Chinese research into neuromorphic devices.”

Quantum anybody?

I haven’t singled it out in this end-of-year posting but there is a great deal of interest in quantum computer both here in Canada and elsewhere. There is a 2023 report from the Council of Canadian Academies on the topic of quantum computing in Canada, which I hope to comment on soon.

Final words

I have a shout out for the Canadian Science Policy Centre, which celebrated its 15th anniversary in 2023. Congratulations!

For everyone, I wish peace on earth and all the best for you and yours in 2024!

Life, death and emergence of something new

Implications for biology and medicine

Evolving Beyond the Xenobot

Cyborg or biohybrid robot?

2.3. Cyborgs

A few notes about BBVA and other items

Misinformation and manipulation on the web

Microrobots for precision medicine

Nano-​electrodes record brain function

The downside of convergence

Converging global regulation is needed

SxSW 2024 (Austin, Texas, US)

TED 2024 (Vancouver, BC, Canada)

Energy, computing and the environment

Neuromorphic (brainlike) computing and lower energy

Some good news

More encouraging developments in environmental science

All by myself (neuromorphic engineering)

Oops! I did it again. More AI panic

A long time coming, a nanomedicine comeuppance

Other players in the Macchiarini story

Promising nanomedicine research but no promises and a caveat

Funky music (sound and noise)

Same old, same old CRISPR

Art/Sci: a pretty active year

Boundaries: life/nonlife

Canada’s 2023 budget … military

10 years: Graphene Flagship Project and Human Brain Project

Future or not

Colonizing the brain?

Quantum anybody?

Final words

Nano-electrodes record brain function