Monthly Archives: March 2023

Celebrating Italian Research in the World Day at The Age of Immunotherapy, an April 12th, 2023 event in Vancouver (Canada)

ARPICO (Society of Italian Researchers and Professionals in Western Canada) is co-presenting an event with the Consulate General of Italy in Vancouver to celebrate Italian Research in World Day.

From a March 21, 2023 ARPICO notice (received via email), Note: i have reformatted parts of the text,

It is our pleasure, with the Consulate General of Italy in Vancouver, to invite you to ARPICO’s next public event “The Age of Immunotherapy” to be held on Wednesday, April 12th, 2023 at 7:00 PM at the Museum of Vancouver, History Room & Garden Patio, 1100 Chestnut Street, Vancouver, BC.

The event is in celebration of Italian Research in the World Day instituted in 2018 to value the quality and competencies of Italian researchers abroad and promote concrete actions and investments to allow Italian researchers to continue pursuing their careers in their homeland as well as make Italy an attractive environment for foreign researchers.

Main Event Details

The Age of Immunotherapy, a lecture by Dr. Gregorio Aversa

The Immune system has evolved primarily to protect the body against foreign pathogens such as viruses, bacteria and fungi but sparing the body, recognizing it as “self”. However, sometimes the immune system can also can attack the body’s own tissues, as in autoimmune diseases, or react against harmless molecules, as in allergies. It is now clear that the immune system can also recognize cancer cells, but their elimination can be challenging as the cancer deploys sophisticated mechanisms to evade the immune surveillance. The deeper understanding of the immune system, the key molecules involved in cancer-immune cell interactions and advances in antibody and cell engineering accumulated over the past three decades, have resulted in the recent development of novel and effective immunotherapeutic treatments for cancer. For example, antibodies that target suppressive signals in immune cells are now used to “awaken” the immune system to kill a variety of tumors, resulting in often curative therapies for previously lethal cancers. Multiple new immunotherapeutic approaches and combinations are currently being developed and clinically tested for a variety of cancers and other diseases such as autoimmune diseases, transplant rejection, allergies and viral infections, thus paving the way for potential cures for currently challenging diseases.

About Our Speaker

Dr. Gregorio Aversa is an experienced immunologist and industrial scientist. He has made significant contributions to the discovery of novel monoclonal antibodies and molecules involved in immune regulation in allergies, autoimmune diseases and transplant rejection. Over the past 25 years Dr. Aversa has held executive leadership positions in global Pharmaceutical companies, Biotech, and a Translational Research Institute. These positions include Senior Vice President of the Centre for Drug Research and Development (CDRD) on UBC campus, Unit Head of the Autoimmune Diseases, Biology and Cellular and Molecular Biology Units at Novartis (Vienna, Austria) and Vice President of Research at Inflazyme Pharmaceuticals. He also previously held positions at the DNAX Research Institute in Palo Alto, California (now Merck), and has been an Adjunct Professor in the Department of Microbiology and Immunology at UBC. Dr. Aversa is currently President of his own private biotechnology business, Abimmune Technologies Inc., in Vancouver, Canada, focusing on the development and commercialization of monoclonal antibodies for research and clinical use. [Note: Dr. Aversa is listed as Principal for Abmedix Biomedical {as of March 24, 2023} on his LinkedIn profile; I cannot websites for either Abmedix or Abimmune.] Dr. Aversa did his Ph.D. work in Transplantation Immunology at the University of Sydney and Stanford University and received his Ph.D. from the University of Sydney School of Medicine in Australia. Dr. Aversa has over 60 publications in international scientific journals and is an inventor on several patents.

Evening Program

  • 6:30 PM – Doors open for registration.
  • 7:00 PM – Start of the event with introductions by the Consul General of Italy, Fabio Messineo, and ARPICO’s president, Nicola Fameli.
  • 7:15 PM – Talk “The Age of Immunotherapy” by Dr. Gregorio Aversa, immunologist and industrial scientist.
  • 8:00 PM – Q & A Period
  • 8:15 PM – Mediterranean refreshments catered by Bottles and Bottega offered by the Consulate General of Italy.

We look forward to seeing everyone there.

RSVP: Tickets for this event are required, but FREE; all wishing to attend are requested to obtain “free-admission” tickets on EventBrite

Further details are also available at arpico.ca, arpico facebook, and EventBrite.

If participants wish to donate to ARPICO, this can be done within EventBrite or in person at the event; this would be greatly appreciated in order to help us continue our public lecture program and to build upon our scholarship fund.

FAQ

  • Where can I contact the organizer with any questions?
  • info@arpico.ca
  • Can I update my registration information?
  • Yes. If you have any questions, contact us at info@arpico.ca
  • I am having trouble using EventBrite and cannot reserve my ticket(s). Can someone at ARPICO help me with my ticket reservation?
  • Of course, simply send your ticket request to us at info@arpico.ca so we can help you.

Happy Italian Research in the World Day!

Frog Finders

Joelle Krol has a March 24, 2023 article in The Tyee (an online publication named after a type of salmon) about a frog project in British Columbia’s Fraser Valley (Canada),

As a junior biologist working for the Fraser Valley Conservancy, I’ve been working on putting together a map of our frog and salamander observations. So much of this data is collected by citizen scientists, who submit their photos or videos to programs like iNaturalist or Fraser Valley Conservancy’s Frog Finders program.

The conservancy focuses a lot of our efforts on amphibians. We do annual surveys in the spring, searching wetlands for frogs and salamanders. We also make efforts to protect and enhance their habitat. But before any of these activities can happen, we need to know where they are. That’s where all these amphibian observations come in.

Thousands of the points on the map started as photos, videos and audio clips that were submitted by citizens — and I’m hoping that if you live in Metro Vancouver, I can convince you to do some citizen science, too. Looking through all the data, you learn how much of an impact a single photo can have.

I found that huge portions of the Fraser Valley are lacking amphibian observations, but other portions are rich with amphibians. From here, I was able to identify “amphibian observation hot spots.” These are areas where many amphibians have been sighted and reported. I also identified areas of interest — where there haven’t been many observations but could be great for amphibians. Many of the hot spots surround public parks or protected areas. Whereas many of the areas of interest contain private land.

[downloaded from https://thetyee.ca/Opinion/2023/03/23/Frog-Finders-Fraser-Valley/]

Here’s the request or call to action from a March 9, 2023 Fraser Valley Conservancy (FVC) news release by Joelle Krol, which originated the article in The Tyee,

Ryder Lake provides a great example of how a picture can make a big difference. Residents of the community noticed toads dying on the roadways that sit between the forest and the wetland. They reported these sightings and reached out for help, which got the conservancy involved.

Because of these reports from the community, the FVC was able to tell which location along the road would be the best place to build a tunnel for the toads. Projects like this make a huge difference for the toads’ survival and wouldn’t be possible without those initial citizen reports.

So many strategies for protecting wildlife begin with citizen science data. While there are a decent number of observations in parks and protected wildlife areas, there are shockingly few on private land. It’s not that amphibians aren’t there, but that they aren’t being reported. That’s where you and your photos come in. Submitting photos to citizen science programs helps to fill the map and can result in real change.

You can find a form on the FVC’s home page so you can submit your sighting. If you want to preview the form, you can find it here.

12th World Conference of Science Journalists in Medellín, Colombia from March 27-31, 2023

I very rarely get a chance to feature science from Latin America and the Caribbean, largely due to my lack of Spanish, Portuguese, or Dutch language skills. So, you might say I’m desperate to find something, which explains, at least in part, why I’m posting about the 12th World Conference (WCSJ).

A March 29, 2023 WCSJ press release (also on EurekAlert but published March 28, 2023) describes the opening day of the 2023 conference,

The opening day [March 27, 2023] of the World Conference of Science Journalists (WCSJ) 2023 in Medellín, Colombia saw hundreds of journalists from 62 countries come together in the stunning setting of the city’s Jardin Botanico.

Over 500 attendees will gather over three days to discuss science journalism, to challenge ideas and to reinforce their professional networks and friendships. 

The day began with a keynote on biodiversity delivered by Brigitte Baptiste, a Colombian biologist and expert in biodiversity issues. And it closed with an opening ceremony and vibrant social event for attendees.

Both took place under open skies in the Jardin’s orquideorama, an open air meshwork of flower-tree structures surrounded by trees, butterflies and with a backdrop of birdsong. 

Two other plenaries focused on scientific advice and news from Amazonia. The morning’s parallel panels covered Latin American and international collaboration, with discussions from Latin American women researchers, reporting on science, health and the environment in the region and what the world can learn from Latin American and the Caribbean early warning alerts systems. The afternoon saw discussions on COVID-19, popular science writing and astronomy. 

The conference continues until Friday when there are scientific tours and excursions that provide the opportunity to visit local research teams and find out more about science in the region.

According to WWF, Colombia is the most biodiverse country per square kilometre in the world. It is also the country with the largest number of bird species — over 1,900  —  and the greatest number of butterfly species — over 3,600 or 20% butterfly species. 

Milica Momcilovic, President of the World Federation of Science Journalists said: “Independent journalism is the lifeblood of democracy and our focus at the Federation is, and will continue to be, supporting independent science journalism around the world. I have seen first hand how talented science journalists can change the world for the better and during this conference they will tell us these stories in person.”

Ximena Serrano Gil, Director of the Medellín conference said: “Colombia and Medellin are a biodiversity hotspot, an unrivalled laboratory for helping other nations adapt to climate change, a model for how to feed populations in rapidly changing tropical environments, and a cultural repository where thousands of years of indigenous peoples’ knowledge can make a lasting contribution to the wisdom of future generations.”

She continued: “The opportunity to share ideas and collaborate with others is invaluable and we must continue to create platforms that facilitate these interactions. I hope that other places in the global south will have the opportunity to host the WCSJ.” 

Over the past two decades, the World Federation of Science Journalists (WFSJ) has mounted the WCSJ every other year. The event has been held in cities across the globe, and the current edition in Medellín, Colombia, was postponed from 2021 because of the COVID-19 pandemic. Each gathering lasts about a week and attracts hundreds of participants from the WFSJ membership, including some 10,000 science writers in 51 countries.

This conference has been put together with a specific focus on the global south and on amplifying new voices from science journalist communities.

The programme has something that interests me, a talk on brain organoids according to a March 17, 2023 WCSJ press release, Note: Links have been removed,

Food security, organoid intelligence, local tours and scientific excursions

Plenary: Challenges to food security in the face of global catastrophe risks

In times of crisis and global risks, very few issues have as many factors feeding into them as food security. The integrative measures envisaged by various global players link the actions that are needed to meet the challenges we face. These should be considered in terms of technology, economics and security to ensure the future of food security, but also how science validates the environmental the environmental impact and guarantees the viability of the processes. 

Jennifer Wiegel is the Sub Regional Manager for Central America and a scientist in the Food Environment and Consumer Behavior research area of the Alliance of Bioversity International and CIAT [International Center for Tropical Agriculture]. Her research includes work on agri-food systems, food markets and value chains for inclusion and sustainability and public procurement. She has a Ph.D. in Sociology from the University of Wisconsin-Madison and a Master’s in Rural Sociology from the same University.

Juan Fernando Zuluaga is the National Territorial Coordinator for Antioquia. He has a  PhD in Social Sciences from the University of Antioquia and a Master in RuralEconomics from the Federal University of Ceará-Brazil. Juan is a specialist in finance from  the Latin American Autonomous University and Agricultural Engineer from the National University of Medellín.

Thomas Hartung, MD, PhD. Professor of environmental health sciences at the Johns Hopkins Bloomberg School of Public Health and Whiting School of Engineering and Professor for Pharmacology and Toxicology at University of Konstanz, Germany. He is leading the revolution in toxicology to move away from 50+ year old animal testing to organoid cultures and the use of artificial intelligence.

New keynote

Climate change: How to embroider the risks that put the stability of the most vulnerable at risk

Paola Andrea Arias Gómez is Professor of the Environmental School of the Faculty of Engineering of the University of Antioquia. In 2021 she was El Espectador’s Person of the Year and received the Medellin Council’s Orchid Award for Scientific Merit.

Paola completed her undergraduate studies in Civil Engineering and a Master’s degree in Water Resources Development at the National University of Colombia, Medellin. She was Head of the Environmental School of the Faculty of Engineering of the University of Antioquia and is now a member of the First Working Group of the Intergovernmental Panel on Climate Change (IPCC). She is also a member of the GEWEX Hydroclimatology Panel (GHP), the Amazon Regional Hydrogeomorphology Working Group (UNESCO) and the WCRP Science Plan Development Team (WCRP) Lighthouse Activities – My Climate Risk.

Parallel session:

In conversation: “Organoid intelligence”: the future of modern computing from human brain cells. [sic]

Biocomputing is a huge effort to compact computational power and increase its efficiency to overcome current technological limits. Researchers at Johns Hopkins delve into this technology that may one day produce computers that are faster, more efficient and more powerful than silicon-based computing and AI.

Thomas Hartung, MD, PhD. will present the team’s latest research and discuss its context, implications and what his hopes are for the field. 

Thomas Hartung is the Director of Centers for Alternatives to Animal Testing (CAAT, http://caat.jhsph.edu) of both universities. CAAT hosts the secretariat of the Evidence-based Toxicology Collaboration (http://www.ebtox.org) and manages collaborative programs on Good Read-Across Practice, Good Cell Culture Practice, Green Toxicology, Developmental Neurotoxicity, Developmental Immunotoxicity, Microphysiological Systems and Refinement.

I found another intriguing session (Story Corner: “Fusion Energy and Climate Change – The Conversation begins” by ITER) which was held on Tuesday, March 28, 2023 at 9:30 – 10:00 am during the coffee break. (For more about fusion energy, see my October 28, 2022 posting “Overview of fusion energy scene“.)

While it’s too late to sign up for the conference, you might find perusing the programme schedule provides some insight into issues being faced my science journalists outside the Canada/US bubble.

2023 Canadian Science Policy Conference (CSPC) from November 13-15, 2023: Call for panel submissions

You have until April 21, 2023 *extended to May 5, 2023* to reply to the call for submissions to present at the 2023 Canadian Science Policy Conference (CSPC) being held from November 13 – 15, 2023 in in Ottawa, Canada. Here’s more about the conference, from the conference themes and topics webpage,

CSPC 2023 Themes & Topics:

Science and Innovation in a Time of Transformation

The 15th Canadian Science Policy Conference (CSPC 2023), will be held in person on November 13th – 15th, 2023. The conference expects 1000+ participants, more than 300 speakers, in 60 panel sessions. CSPC 2022 will also include a spectacular Gala dinner featuring its award ceremony which has become a signature annual event to celebrate Canadian science and innovation policy achievements.

We invite you to submit proposals in a variety of presentation formats that revolve around any of the conference topics. The conference tracks and topic can be found below

CSPC 2023 Overarching Theme:
Science and Innovation in a Time of Transformation

Track 1: Science and Policy

  • The national STI [Science, technology, and innovation] ecosystem: Strategy for the next ten years; building on strengths and opportunities; addressing weaknesses
    • Modernizing the federal research support system
    • Strengthening Intergovernmental coordination and cooperation
    • Learning from international experiences
    • Assessing and fostering Canadian global leadership in STI
    • Governance of Science, technology and innovation
  • Managing the evolving/changing research landscape
    • Inter- and trans-disciplinarity, co-production of knowledge, effective integration of all fields of knowledge and ways of knowing
    • Science for social and economic objectives (including the UN SDGs)
    • Research security
    • Barriers and Opportunities in Open Science
    • Braiding Indigenous and Western knowledge
    • Optimizing benefits from national infrastructures, including data as infrastructure
    • Equity, diversity, inclusion, and racism in science
  • Evidence for policy
    • Science advice for Parliament
    • Best practices for bridging research and policy
    • Standardization, quality and transparency
    • The impact of ChatGPT
  • Science policy futures

Track 2: Science and Society

  • Public trust
    • Mis- and disinformation
    • Science communication in a post-truth era
    • Diverse forms of knowledge and ways of knowing
    • Science and social justice
    • Social trust, cohesion, social innovation
  • Systemic racism, otherism
  • Science in support of democracy
  • Science and Truth and Reconciliation
  • Science policy and aging
  • Science, technology and ethics
  • Science and innovation: public education

Track 3: Innovation and Economic Development

  • Canada’s Innovation strategy, 10 years outlook
    • Innovation in government investments in R&D and innovation
    • Regional development and innovation actions
    • Global Innovation Clusters
    • Digital challenges and strategy
  • Emerging economic opportunities
    • The conservation economy & the circular economy
    • The blue economy
  • Emerging and disruptive technologies
    • AI, including Chat GPT
    • Quantum
    • Gene editing
    • Ethical dimensions
  • Sector policies and challenges
    • Canadian Mineral Strategy
    • Facilitating the energy transition, including transportation infrastructure
    • Biomanufacturing capacity, security and competitiveness
    • Cleantech

Track 4: Science, International Affairs and Security

  • International STI agreements and Canada’s interest,
  • Assessing and fostering Canadian global leadership in STI
    Managing Canada’s approaches to emerging international industrial strategies and knowledge sharing
  • International opportunities, e.g.,
    • Horizon Europe
    • The Indo-Pacific strategy [emphases mine]
  • International collaboration
    • Large, concerted projects and major facilities
    • Security and cyber security
    • Foreign investment
    • Science, technology, innovation in the context of geopolitical shifts
  • Science diplomacy and geopolitics

Track 5: Science and The Next Generation

  • Research training
    • Revisiting the PhD
    • The welfare of research trainees
    • Fostering the next generation of science policy experts
  • Career transitions
    • Transitions between sectors in the science ecosystem

Track 6: Grand Challenges

  • Climate change
    • Mitigation and adaptation
    • Informing climate change action with data
    • Net Zero
    • Water resources and conservation
    • Nature-based solutions
  • Healthcare
    • Measuring healthcare outcomes
    • Towards meaningful indicators of the health system
    • Accessibility of health data
    • Issues in sharing, using and reporting health data
    • Pandemic preparedness
  • One Health
    • Zoonotic diseases
    • Environmental Health
    • Vector born diseases
  • The North
    • Permafrost – the next big challenge
    • Science, security and Canada’s Arctic
  • Food and agriculture
    • Future of food
    • A national food strategy?
    • Food Safety
  • Energy sovereignty

Nice to see interest in the Indo-Pacific region. Unsurprisingly given that these discussions are dominated by policy wonks from central and eastern Canada (heavily dominated by Ontario), Europe is mentioned first.

Regarding the call, I have more information from the CSPC 2023 Panel Proposal Criteria webpage, Note: I have made some formatting changes,

1.Submission type: There are two types of submissions;

a) Panel proposals (CSPC 2023 Overarching Theme, Tracks, and Topics)

80 minute panels (50 minute presentation, 30 minutes for Q&A session) where a diverse, multisectoral group discusses topics in science policy (see CSPC 2023 Overarching Theme, Tracks, and Topics)

b) Short talk proposals. (maximum 12 submissions will be accepted)

10 minute presentations (8 minute presentation, 2 minutes for Q&A session) that are intended to provide a brief overview of a topic in science policy.

Please read the criteria for each stream carefully before finalizing your submission.

2. Please review the CSPC 2023 Overarching Theme, Tracks, and Topics here.

3. CSPC 2023 will be an in-Person Conference: To participate in the in-person conference between Nov-13-15, 2023, at Westin Hotel Ottawa, Ontario, panelists must be present on-site. (In exceptional cases, we will try to accommodate virtual attendance for select speakers).

4. There is NO fee associated with proposal submission. However, CSPC is not responsible for speakers’ travel and accommodation costs. Speakers are entitled to register at a discounted rate.

5. Panel Diversity: CSPC is a national forum and mosaic that is built upon a balanced representation of diversity including region, sector, ethnicity, gender, age, and topic, in addition to seeking to provide under-represented groups an opportunity to present their ideas. These criteria will be heavily considered in the final selection of panels.

6. The Program Committee, alongside external reviewers from the community, will make selections based on the following criteria.

Proposals will be ranked based on the following high level criteria:

Panel Proposals (full description of criteria is below)

Quality of the proposed session: proposal description and justification (35%)

An action and/or solution-oriented focus, as opposed to a statement of the status quo of an issue (15%)

A diverse range of panelists (20%)

Quality of the speakers and moderator (15%)

Creativity in choice of panel format and its interactivity (15%)

Full Description of Criteria

1. Quality of the proposed session: proposal description and justification (35%)

The Quality of the session is evaluated on the panel description and justification:

Deep comprehension of the issue

Clear and compelling description of the panel and its novelty and importance to, and impact on, society

The value of the panel to be discussed at CSPC, in terms of follow ups, calls to action, policy change, etc.

Alignment with the Conference theme and topics

2. Incorporation of an action and/or solution-oriented focus, as opposed to a statement of the status quo of an issue (15%)

CSPC is seeking sessions that focus on solutions, forward actions and a futuristics analysis, rather than just a reiteration of the status quo.

Good luck!

*Change made on April 6, 2023. Newly extended date for submissions received via email in an April 6, 2023 Canadian Science Policy Centre announcement.*

Embroidery as a low-cost solution for making wearable electronics?

A November 22, 2022 news item on Nanowerk explores embroidery as a means for affixing wearable electronics to textiles,

Embroidering power-generating yarns onto fabric allowed researchers to embed a self-powered, numerical touch-pad and movement sensors into clothing. The technique offers a low-cost, scalable potential method for making wearable devices.

“Our technique uses embroidery, which is pretty simple – you can stitch our yarns directly on the fabric,” said the study’s lead author Rong Yin, assistant professor of textile engineering, chemistry and science at North Carolina State University. “During fabric production, you don’t need to consider anything about the wearable devices. You can integrate the power-generating yarns after the clothing item has been made.”

Caption: Yu Chen, graduate student at NC State, demonstrates embroidery techniques. Courtesy: North Caroline State University

A North Carolina State University November 22, 2022 news release (also on EurekAlert), which originated the news item, describes the research in more detail,

In the study published in Nano Energy, researchers tested multiple designs for power-generating yarns. To make them durable enough to withstand the tension and bending of the embroidery stitching process, they ultimately used five commercially available copper wires, which had a thin polyurethane coating, together. Then, they stitched them onto cotton fabric with another material called PTFE.

“This is a low-cost method for making wearable electronics using commercially available products,” Yin said. “The electrical properties of our prototypes were comparable to other designs that relied on the same power generation mechanism.”

The researchers relied on a method of generating electricity called the “triboelectric effect,” which involves harnessing electrons exchanged by two different materials, like static electricity. They found the PTFE fabric had the best performance in terms of voltage and current when in contact with the polyurethane-coated copper wires, as compared to other types of fabric that they tested, including cotton and silk. They also tested coating the embroidery samples in plasma to increase the effect.

In our design, you have two layers – one is your conductive, polyurethane-coated copper wires, and the other is PTFE, and they have a gap between them,” Yin said. “When the two non-conductive materials come into contact with each other, one material will lose some electrons, and some will get some electrons. When you link them together, there will be a current.”

Researchers tested their yarns as motion sensors by embroidering them with the PTFE fabric on denim. They placed the embroidery patches on the palm, under the arm, at the elbow and at the knee to track electrical signals generated as a person moves. They also attached fabric with their embroidery on the insole of a shoe to test its use as a pedometer, finding their electrical signals varied depending on whether the person was walking, running or jumping.

Lastly, they tested their yarns in a textile-based numeric keypad on the arm, which they made by embroidering numbers on a piece of cotton fabric, and attaching them to a piece of PTFE fabric. Depending on the number that the person pushed on the keypad, they saw different electrical signals generated for each number.

“You can embroider our yarns onto clothes, and when you move, it generates an electrical signal, and those signals can be used as a sensor,” Yin said. “When we put the embroidery in a shoe, if you are running, it generates a higher voltage than if you were just walking. When we stitched numbers onto fabric, and press them, it generates a different voltage for each number. It could be used as an interface.”

Since textile products will inevitably be washed, they tested the durability of their embroidery design in a series of washing and rubbing tests. After hand washing and rinsing the embroidery with detergent, and drying it in an oven, they found no difference or a slight increase in voltage. For the prototype coated in plasma, they found weakened but still superior performance compared with the original sample. After an abrasion test, they found that there was no significant change in electrical output performance of their designs after 10,000 rubbing cycles.

In future work, they plan to integrate their sensors with other devices to add more functions.

“The next step is to integrate these sensors into a wearable system,” Yin said.

Here’s a link to and a citation for the paper,

Flexible, durable, and washable triboelectric yarn and embroidery for self-powered sensing and human-machine interaction by Yu Chen, Erdong Chen, Zihao Wang, Yali Ling, Rosie Fisher, Mengjiao Li, Jacob Hart, Weilei Mu, Wei Gao, Xiaoming Tao, Bao Yang and Rong Yin. Nano Energy Volume 104, Part A, 15 December 2022, 107929 DOI: 10.1016/j.nanoen.2022.107929 Available online: 27 October 2022 Version of Record: 4 November 2022.

This paper is behind a paywall.

“Living in a Dream,” part of Cambridge Festival (on display March 31 and April 1, 2023 in the UK)

Caption: Dream artwork by Jewel Chang of Anglia Ruskin University, which will be on display at the Cambridge Festival. Credit: Jewel Chang, Anglia Ruskin University

Let’s clear up a few things. First, as noted in the headline, the Cambridge Festival (March 17 – April 2, 2023) is being held in the UK by the University of Cambridge in the town of Cambridge. Second, the specific festival event featured here is a display put together by students and professors at Anglia Ruskin University (ARU) and in the town of Cambridge as part of the festival and will be held for two days, March 31 – April 1, 2023.

A March 27, 2023 ARU press release (also on EurekAlert) provides more details about the two day display, Note: Links have been removed,

Dreams are being turned into reality as new research investigating the unusual experiences of people with depersonalisation symptoms is being brought to life in an art exhibition at Anglia Ruskin University (ARU) in Cambridge, England.

ARU neuroscientist Dr Jane Aspell has led a major international study into depersonalisation, funded by the Bial Foundation. The “Living in a Dream” project, results from which will be published later this year, found that people who experience depersonalisation symptoms sometimes experience life from a very different perspective, both while awake and while dreaming.

Those experiencing depersonalisation often report feeling as though they are not real and that their body does not belong to them. Dr Aspell’s study, which is the first to examine how people with this disorder experience dreams, collected almost 1,000 dream reports from participants.

Now these dreams have been recreated by eight students from ARU’s MA Illustration course and the artwork will go on display for the first time on 31 March and 1 April as part of the Cambridge Festival.

This collaboration between art and science, led by psychologist Matt Gwyther and illustrator Dr Nanette Hoogslag, with the support of artist and creative technologist Emily Godden, has resulted in 12 original artworks, which have been created using the latest audio-visual technologies, including artificial intelligence (AI), and are presented using a mix of audio-visual installation, virtual reality (VR) experiences, and traditional media.

Dr Jane Aspell, Associate Professor of Cognitive Neuroscience at ARU and Head of the Self and Body Lab, said: “People who experience depersonalisation sometimes feel detached from their self and body, and a common complaint is that it’s like they are watching their own life as a film.

“Because their waking reality is so different, myself and my international collaborators – Dr Anna Ciaunica, Professor Bigna Lenggenhager and Dr Jennifer Windt – were keen to investigate how they experience their dreams.

“People who took part in the study completed daily ‘dream diaries’, and it is fabulous to see how these dreams have been recreated by this group of incredibly talented artists.”

Matt Gwyther added: “Dreams are both incredibly visual and surreal, and you lose so much when attempting to put them into words. By bringing them to life as art, it has not only produced fabulous artwork, but it also helps us as scientists better understand the experiences of our research participants.”

Amongst the artists contributing to the exhibition is MA student Jewel Chang, who has recreated a dream about being chased. When the person woke up, they continued to experience it and were unsure whether they were experiencing the dream or reality.

False awakenings and multiple layers of dreams can be confusing, affecting our perception of time and space. Jewel used AI to create an environment with depth and endless moving patterns that makes the visitor feel trapped in their dream, unable to escape.

Kelsey Wu, meanwhile, used special 3D software and cameras to recreate a dream of floating over hills and forests, and losing balance. The immersive piece, with the audience invited to sit on a grass-covered floor, creates a sense of loss of control of the body, which moves in an abnormal and unbalanced way, and evokes a struggle between illusion and reality as the landscape continuously moves.

Dr Nanette Hoogslag, Course Leader for the MA in Illustration at ARU, said: “This project has been a unique challenge, where students not only applied themselves in supporting scientific research, but investigated and used a range of new technologies, including virtual reality and AI-generated imagery. The final pieces are absolutely remarkable, and also slightly unsettling!”

You can find out more about the 2023 Cambridge Festival here and about the Anglia Ruskin University exhibit, “Living in a Dream: A visual exploration of the self in dreams using AI technology” here.

Sleep helps artificial neural networks (ANNs) to keep learning without “catastrophic forgetting”

A November 18, 2022 news item on phys.org describes some of the latest work on neuromorphic (brainlike) computing from the University of California at San Diego (UCSD or UC San Diego), Note: Links have been removed,

Depending on age, humans need 7 to 13 hours of sleep per 24 hours. During this time, a lot happens: Heart rate, breathing and metabolism ebb and flow; hormone levels adjust; the body relaxes. Not so much in the brain.

“The brain is very busy when we sleep, repeating what we have learned during the day,” said Maxim Bazhenov, Ph.D., professor of medicine and a sleep researcher at University of California San Diego School of Medicine. “Sleep helps reorganize memories and presents them in the most efficient way.”

In previous published work, Bazhenov and colleagues have reported how sleep builds rational memory, the ability to remember arbitrary or indirect associations between objects, people or events, and protects against forgetting old memories.

Artificial neural networks leverage the architecture of the human brain to improve numerous technologies and systems, from basic science and medicine to finance and social media. In some ways, they have achieved superhuman performance, such as computational speed, but they fail in one key aspect: When artificial neural networks learn sequentially, new information overwrites previous information, a phenomenon called catastrophic forgetting.

“In contrast, the human brain learns continuously and incorporates new data into existing knowledge,” said Bazhenov, “and it typically learns best when new training is interleaved with periods of sleep for memory consolidation.”

Writing in the November 18, 2022 issue of PLOS Computational Biology, senior author Bazhenov and colleagues discuss how biological models may help mitigate the threat of catastrophic forgetting in artificial neural networks, boosting their utility across a spectrum of research interests. 

A November 18, 2022 UC San Diego news release (also one EurekAlert), which originated the news item, adds some technical details,

The scientists used spiking neural networks that artificially mimic natural neural systems: Instead of information being communicated continuously, it is transmitted as discrete events (spikes) at certain time points.

They found that when the spiking networks were trained on a new task, but with occasional off-line periods that mimicked sleep, catastrophic forgetting was mitigated. Like the human brain, said the study authors, “sleep” for the networks allowed them to replay old memories without explicitly using old training data. 

Memories are represented in the human brain by patterns of synaptic weight — the strength or amplitude of a connection between two neurons. 

“When we learn new information,” said Bazhenov, “neurons fire in specific order and this increases synapses between them. During sleep, the spiking patterns learned during our awake state are repeated spontaneously. It’s called reactivation or replay. 

“Synaptic plasticity, the capacity to be altered or molded, is still in place during sleep and it can further enhance synaptic weight patterns that represent the memory, helping to prevent forgetting or to enable transfer of knowledge from old to new tasks.”

When Bazhenov and colleagues applied this approach to artificial neural networks, they found that it helped the networks avoid catastrophic forgetting. 

“It meant that these networks could learn continuously, like humans or animals. Understanding how human brain processes information during sleep can help to augment memory in human subjects. Augmenting sleep rhythms can lead to better memory. 

“In other projects, we use computer models to develop optimal strategies to apply stimulation during sleep, such as auditory tones, that enhance sleep rhythms and improve learning. This may be particularly important when memory is non-optimal, such as when memory declines in aging or in some conditions like Alzheimer’s disease.”

Here’s a link to and a citation for the paper,

Sleep prevents catastrophic forgetting in spiking neural networks by forming a joint synaptic weight representation by Ryan Golden, Jean Erik Delanois, Pavel Sanda, Maxim Bazhenov. PLOS [Computational Biology] DOI: https://doi.org/10.1371/journal.pcbi.1010628 Published: November 18, 2022

This paper is open access.

Turning asphaltene into graphene

Asphaltene (or asphaltenes are) is waste material that can be turned into graphene according to scientists at Rice University (Texas, US), from a November 18, 2022 news item on ScienceDaily,

Asphaltenes, a byproduct of crude oil production, are a waste material with potential. Rice University scientists are determined to find it by converting the carbon-rich resource into useful graphene.

Muhammad Rahman, an assistant research professor of materials science and nanoengineering, is employing Rice’s unique flash Joule heating process to convert asphaltenes instantly into turbostratic (loosely aligned) graphene and mix it into composites for thermal, anti-corrosion and 3D-printing applications.

The process makes good use of material otherwise burned for reuse as fuel or discarded into tailing ponds and landfills. Using at least some of the world’s reserve of more than 1 trillion barrels of asphaltene as a feedstock for graphene would be good for the environment as well.

A November 17, 2022 Rice University news release (also on EurekAlert), which originated the news item, expands on this exciting news, Note: Links have been removed,

“Asphaltene is a big headache for the oil industry, and I think there will be a lot of interest in this,” said Rahman, who characterized the process as both a scalable and sustainable way to reduce carbon emissions from burning asphaltene.

Rahman is a lead corresponding author of the paper in Science Advances co-led by Rice chemist James Tour, whose lab developed flash Joule heating, materials scientist Pulickel Ajayan and Md Golam Kibria, an assistant professor of chemical and petroleum engineering at the University of Calgary, Canada.

Asphaltenes are 70% to 80% carbon already. The Rice lab combines it with about 20% of carbon black to add conductivity and flashes it with a jolt of electricity, turning it into graphene in less than a second. Other elements in the feedstock, including hydrogen, nitrogen, oxygen and sulfur, are vented away as gases.

“We try to keep the carbon black content as low as possible because we want to maximize the utilization of asphaltene,” Rahman said.

“The government has been putting pressure on the petroleum industries to take care of this,” said Rice graduate student and co-lead author M.A.S.R. Saadi. “There are billions of barrels of asphaltene available, so we began working on this project primarily to see if we could make carbon fiber. That led us to think maybe we should try making graphene with flash Joule heating.”

Assured that Tour’s process worked as well on asphaltene as it did on various other feedstocks, including plastic, electronic waste, tires, coal fly ash and even car parts, the researchers set about making things with their graphene. 

Saadi, who works with Rahman and Ajayan, mixed the graphene into composites, and then into polymer inks bound for 3D printers. “We’ve optimized the ink rheology to show that it is printable,” he said, noting the inks have no more than 10% of graphene mixed in. Mechanical testing of printed objects is forthcoming, he said.

Rice graduate student Paul Advincula, a member of the Tour lab, is co-lead author of the paper. Co-authors are Rice graduate students Md Shajedul Hoque Thakur, Ali Khater, Jacob Beckham and Minghe Lou, undergraduate Aasha Zinke and postdoctoral researcher Soumyabrata Roy; research fellow Shabab Saad, alumnus Ali Shayesteh Zeraati, graduate student Shariful Kibria Nabil and postdoctoral associate Md Abdullah Al Bari of the University of Calgary; graduate student Sravani Bheemasetti and Venkataramana Gadhamshetty, an associate professor, at the South Dakota School of Mines and Technology and its 2D Materials of Biofilm Engineering Science and Technology Center; and research assistant Yiwen Zheng and Aniruddh Vashisth, an assistant professor of mechanical engineering, of the University of Washington.

The research was funded by the Alberta Innovates for Carbon Fiber Grand Challenge programs, the Air Force Office of Scientific Research (FA9550-19-1-0296), the U.S. Army Corps of Engineers (W912HZ-21-2-0050) and the National Science Foundation (1849206, 1920954).  

Here’s a link to and a citation for the paper,

Sustainable valorization of asphaltenes via flash joule heating by M.A.S.R. Saadi, Paul A. Advincula, Md Shajedul Hoque Thakur, Ali Zein Khater, Shabab Saad, Ali Shayesteh Zeraati, Shariful Kibria Nabil, Aasha Zinke, Soumyabrata Roy, Minghe Lou, Sravani N. Bheemasetti, Md Abdullah Al Bari, Yiwen Zheng, Jacob L. Beckham, Venkataramana Gadhamshetty, Aniruddh Vashisth, Md Golam Kibria, James M. Tour, Pulickel M. Ajayan, and Muhammad M. Rahman. Science Advances 18 Nov 2022 Vol 8, Issue 46 DOI: 10.1126/sciadv.add3555

This paper is open access.

Treating traumatic muscle loss with tissue nanotransfection

A November 9, 2022 news item on ScienceDaily announces some work from Indiana University (US),

Technology developed by researchers at the Indiana University School of Medicine that can change skin tissue into blood vessels and nerve cells has also shown promise as a treatment for traumatic muscle loss.

Tissue nanotransfection is a minimally invasive nanochip device that can reprogram tissue function by applying a harmless electric spark to deliver specific genes in a fraction of a second.

A November 9, 2022 Indiana University news release (also on EurekAlert), which originated the news item, provides additional technical details, Note: Links have been removed,

A new study, published in Nature Partner Journals Regenerative Medicine, tested tissue nanotransfection-based gene therapy as a treatment, with the goal of delivering a gene known to be a major driver of muscle repair and regeneration. They found that muscle function improved when tissue nanotransfection was used as a therapy for seven days following volumetric muscle loss in rats. It is the first study to report that tissue nanotransfection technology can be used to generate muscle tissue and demonstrates its benefit in addressing volumetric muscle loss.

Volumetric muscle loss is the traumatic or surgical loss of skeletal muscle that results in compromised muscle strength and mobility. Incapable of regenerating the amount of lost tissue, the affected muscle undergoes substantial loss of function, thus compromising quality of life. A 20 percent loss in mass can result in an up to 90 percent loss in muscle function.

Current clinical treatments for volumetric muscle loss are physical therapy or autologous tissue transfer (using a person’s own tissue), the outcomes of which are promising but call for improved treatment regimens.

“We are encouraged that tissue nanotransfection is emerging as a versatile platform technology for gene delivery, gene editing and in vivo tissue reprogramming,” said Chandan Sen, director of the Indiana Center for Regenerative Medicine and Engineering, associate vice president for research and Distinguished Professor at the IU School of Medicine. “This work proves the potential of tissue nanotransfection in muscle tissue, opening up a new avenue of investigational pursuit that should help in addressing traumatic muscle loss. Importantly, it demonstrates the versatility of the tissue nanotransfection technology platform in regenerative medicine.”

Sen also leads the regenerative medicine and engineering scientific pillar of the IU Precision Health Initiative and is lead author on the new publication.

The Indiana Center for Regenerative Medicine and Engineering is home to the tissue nanotransfection technology for in vivo tissue reprogramming, gene delivery and gene editing. So far, tissue nanotransfection has also been achieved in blood vessel and nerve tissue. In addition, recent work has shown that topical tissue nanotransfection can achieve cell-specific gene editing of skin wound tissue to improve wound closure.

Here’s a link to and a citation for the paper,

Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss by Andrew Clark, Subhadip Ghatak, Poornachander Reddy Guda, Mohamed S. El Masry, Yi Xuan, Amy Y. Sato, Teresita Bellido & Chandan K. Sen. npj Regenerative Medicine volume 7, Article number: 63 (2022) DOI: https://doi.org/10.1038/s41536-022-00259-y Published: 20 October 2022

This paper is open access.

This is a very nice image of a delighted Dr. Sen,

Caption Chandan Sen Credit: Photo by Liz Kaye, Indiana University

Students from Nakoda Oyade Education Centre and scientists at the Canadian Light Source (CLS) use science to help bison

It’s known as Paskwâwimostos – ᐸᐢᑳᐧᐃᐧᒧᐢᑐᐢ – The Bison Project and is being conducted at Canada’s only synchrotron, the Canadian Light Source (CLS) in Saskatoon, Saskatchewan. Here’s more from a November 24, 2022 CLS news release (also received via email), Note: Links have been removed,

Bison have long held a prominent place in the culture of the Carry the Kettle Nakoda Nation, located about 100 kms east of Regina. The once-abundant animals were a vital source of food and furs for the ancestors of today’s Carry the Kettle people.

Now, high school students from Nakoda Oyade Education Centre at Carry the Kettle are using synchrotron imaging to study the health of a local bison herd, with an eye to protecting and growing their numbers.

Armin Eashappie, a student involved in the Bison Project, says the work she and her classmates are doing is a chance to give back to an animal that was once integral to the very existence of her community. “We don’t want them to go extinct, says Eashappie. “They helped us with everything. We got our tools, our clothes, our food from them. We used every single part of the buffalo, nothing was left behind…they
even helped us make our homes – the teepees – we used the hides to cover them up.”

Eashappie’s classmate, Leslie Kaysaywaysemat, says that if their team can identify items the bison are eating that are not good for their health, these could potentially be replaced by other, healthier items. “We want to preserve them and make sure all generations can see how magnificent these creatures are,” he says.

The students, who are participating in the CLS’s Bison Project, gathered samples of bison hair, soil from where the animals graze, and plants they feed on, then analyzed them using the IDEAS beamline at the CLS. The Bison Project, coordinated by the Education group of the CLS, integrates Traditional Knowledge and mainstream science in a transformative research experience for First Nation, Métis, and Inuit
students.

Timothy Eashappie, Elder for the Bison Project, says it’s “awesome” that the students can use the Canadian Light Source machine to learn more about an animal that his people have long taken care of on the prairies. “That’s how we define ourselves – as
Buffalo People,” says Eashappie. “Since the beginning of time, they gave themselves to us, and now these young people are finding out how important these buffalo are to them, because it preserves their language, their culture, and their way of life. And now it’s our turn to take care of the bison.”

Once they’ve completed their analysis, the students will share their findings with the Chief and Council for Carry the Kettle.

The Canadian Light Source (CLS) is a national research facility of the University of Saskatchewan and one of the largest science projects in Canada’s history. More than 1,000 academic, government and industry scientists from around the world use the CLS every year in innovative health, agriculture, environment, and advanced materials research.

The Canada Foundation for Innovation [CFI], Natural Sciences and Engineering Research Council [NSERC], Canadian Institutes of Health Research [CIHR], the Government of Saskatchewan, and the University of Saskatchewan fund CLS operations.

You can find more about the CLS Bison Project here,

The Bison Project integrates Traditional Knowledge (TK) and mainstream Science in an experience that engages First Nation, Métis, and Inuit (FNMI) teachers, students, and communities. The Bison Project creates a unique opportunity to incorporate land-based hunting and herd management, synchrotron science, mainstream science principles and TK.

I found a bit more information about bison and their return in a November 23, 2020 article by Mark A. Bonta for The Daylighter,

For ecologists and environmentalists, it’s more than just a story about the return of a keystone species. 

The bison, it turns out, is an animal that maintains and restores the prairie.

Ecological restoration

Unlike cattle, bison are wallowers, so these powerful animals’ efforts to rid themselves of insect parasites, by rubbing their hide and rolling around on the ground, actually create permanent depressions, called bison wallows, in the landscape. 

These create fertile ground for diverse plant species — and the animals that rely on them. 

Bison also rub against woody plants and kill them off, keeping the prairies open, while their dung fertilizes the soil.

Iconic species like the greater prairie-chicken and the prairie dog all benefit from the restoration of bison. 

Bison herds have also proved highly adaptive to the “new,” post-colonial ecology of the Great Plains.

They are adapting to hunting season, for example, by delaying their migration. This keeps them out of harm’s way — but also increases the risk of human-bison conflicts.

Bonta’s article provides a little more detail about the mixed feelings that the return of the bison have engendered.