I have two bits of news as noted in the headline. There’s news about TRIUMF located on the University of British Columbia (UBC) endowment lands and news about Dr. Suzanne Simard (UBC Forestry) and her memoir, Finding the Mother Tree: Discovering the Wisdom of the Fores.
Nigel Smith and TRIUMF (Canada’s national particle accelerator centre)
As soon as I saw his first name, Nigel, I bet myself he’d be from the UK (more about that later in this posting). This is TRIUMF’s third CEO since I started science blogging in May 2008. When I first started it was called TRIUMF (Canada’s National Laboratory for Particle and Nuclear Physics) but these days it’s TRIUMF (Canada’s national particle accelerator centre).
Dr. Nigel Smith, Executive Director of SNOLAB, has been selected to serve as the next Director of TRIUMF.
Succeeding Dr. Jonathan Bagger, who departed TRIUMF in January 2021 to become CEO of the American Physical Society, Dr. Smith’s appointment comes as the result of a highly competitive, six-month international search. Dr. Smith will begin his 5-year term as TRIUMF Director on May 17, 2021.
“I am truly honoured to have been selected as the next Director of TRIUMF”, said Dr. Smith. “I have long been engaged with TRIUMF’s vibrant community and have been really impressed with the excellence of its science, capabilities and people. TRIUMF plays a unique and vital role in Canada’s research ecosystem and I look forward to help continue the legacy of excellence upheld by Dr. Jonathan Bagger and the previous TRIUMF Directors”.
Describing what interested him in the position, Smith spoke to the breadth and impact of TRIUMF’s diverse science programs, stating “TRIUMF has an amazing portfolio of research covering fundamental and applied science that also delivers tangible societal impact through its range of medical and commercialisation initiatives. I am extremely excited to have the opportunity to lead a laboratory with such a broad and world-leading science program.”
“Nigel brings all the necessary skills and background to the role of Director,” said Dr. Digvir Jayas, Interim Director of TRIUMF, Chair of the TRIUMF Board of Management, and Vice-President, Research and International at the University of Manitoba. “As Executive Director of SNOLAB, Dr. Smith is both a renowned researcher and experienced laboratory leader who offers a tremendous track record of success spanning the local, national, and international spheres. The Board of Management is thrilled to bring Nigel’s expertise to TRIUMF so he may help guide the laboratory through many of the exciting developments on the horizon.
Dr. Smith joins TRIUMF at an important period in the laboratory’s history, moving into the second year of our current Five-Year Plan (2020-2025) and preparing to usher in a new era of science and innovation that will include the completion of the Advance Rare Isotope Laboratory (ARIEL) and the Institute for Advanced Medical Isotopes (IAMI) [not to be confused with Amii {Alberta Machine Intelligence Institute}]. This new infrastructure, alongside TRIUMF’s existing facilities and world-class research programs, will solidify Canada’s position as a global leader in both fundamental and applied research.
Dr. Smith expressed his optimism for TRIUMF, saying “I am delighted to have this opportunity, and it will be a pleasure to lead the laboratory through this next exciting phase of our growth and evolution.”
Smith is leaving what is probably one of the more unusual laboratories, at a depth of 2km, SNOLAB is the deepest, cleanest laboratory in the world. (more information either at SNOLAB or its Wikipedia entry.)
Nigel Smith joined SNOLAB as Director during July 2009. He currently holds a full Professorship at Laurentian University, adjunct Professor status at Queen’s University, and a visiting Professorial chair at Imperial College, London. He received his Bachelor of Science in physics from Leeds University in the U.K. in 1985 and his Ph. D. in astrophysics from Leeds in 1991. He has served as a lecturer at Leeds University, a research associate at Imperial College London, group leader (dark matter) and deputy division head at the STFC Rutherford Appleton Laboratory, before relocating to Canada to oversee the SNOLAB deep underground facility.
I don’t know if this is going to be a trend but this is the second ‘Nigel” to lead TRIUMF. (The Nigels are now tied with the Johns and the Alans. Of course, the letter ‘j’ seems the most popular with four names, John, John, Jack, and Jonathan.) Here’s a list of TRIUMF’s previous CEOs (from the TRIUMF Wikipedia entry),
Since its inception, TRIUMF has had eight directors [now nine] overseeing its operations.
The first Nigel (Lockyer) is described as an American in his Wikipedia entry. He was born in Scotland and raised in Canada. However, he has spent the majority of his adult life in the US, other than the five or six years at TRIUMF. So, previous Nigel also started life in the UK.
Good luck to the new Nigel.
UBC forestry professor, Suzanne Simard’s memoir going to the movies?
Given that Simard’s memoir, Finding the Mother Tree: Discovering the Wisdom of the Forest, was published last week on May 4, 2021, this is very heady news,. From a May 12, 2021 article by Cassandra Gill for the Daily Hive (Note: Links have been removed),
Jake Gyllenhaal is bringing the story of a UBC professor to the big screen.
The Oscar nominee’s production company, Nine Stories, is producing a film based on Suzanne Simard’s memoir, Finding the Mother Tree.
Amy Adams is set to play Simard, who is a forest ecology expert renowned for her research on plants and fungi.
Adams is also co-producing the film with Gyllenhaal through her own company, Bond Group Entertainment.
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The BC native [Simard] developed an interest in trees and the outdoors through her close relationship with her grandfather, who was a horse logger.
Her 30 year career and early life is documented in the memoir, which was released last week on May 4 [2021]. Simard explores how trees have evolved, have memories, and are the foundation of our planet’s ecosystem — along with her own personal experiences with grief.
The scientists’ [sic] influence has had influence in popular culture, notably in James Cameron’s 2009 film Avatar. The giant willow-like “Tree of Souls” was specifically inspired by Simard’s work.
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No mention of a script and no mention of financing, so, it could be a while before we see the movie on Netflix, Apple+, HBO, or maybe a movie house (if they’re open by then).
I think the script may prove to the more challenging aspect of this project. Here’s the description of Simard’s memoir (from the Finding the Mother Tree webpage on suzannesimard.com)
From the world’s leading forest ecologist who forever changed how people view trees and their connections to one another and to other living things in the forest–a moving, deeply personal journey of discovery.
About the Book
In her first book, Simard brings us into her world, the intimate world of the trees, in which she brilliantly illuminates the fascinating and vital truths – that trees are not simply the source of timber or pulp, but are a complex, interdependent circle of life; that forests are social, cooperative creatures connected through underground networks by which trees communicate their vitality and vulnerabilities with communal lives not that different from our own.
Simard writes – in inspiring, illuminating, and accessible ways – how trees, living side by side for hundreds of years, have evolved, how they perceive one another, learn and adapt their behaviors, recognize neighbors, and remember the past; how they have agency about the future; elicit warnings and mount defenses, compete and cooperate with one another with sophistication, characteristics ascribed to human intelligence, traits that are the essence of civil societies – and at the center of it all, the Mother Trees: the mysterious, powerful forces that connect and sustain the others that surround them.
How does Simard’s process of understanding trees and conceptualizing a ‘mother tree’ get put into a script for a movie that’s not a documentary or an animation?
Movies are moving pictures, yes? How do you introduce movement and action in a script heavily focused on trees, which operate on a timescale that’s vastly different.
It’s an interesting problem and I look forward to seeing how it’s resolved. I wish them good luck.
Markus Buehler and his musical spider webs are making news again.
Caption: Cross-sectional images (shown in different colors) of a spider web were combined into this 3D image and translated into music. Credit: Isabelle Su and Markus Buehler
The image (so pretty) you see in the above comes from a Markus Buehler presentation that was made at the American Chemical Society (ACS) meeting. ACS Spring 2021 being held online April 5-30, 2021. The image was also shown during a press conference which the ACS has made available for public viewing. More about that later in this posting.
Spiders are master builders, expertly weaving strands of silk into intricate 3D webs that serve as the spider’s home and hunting ground. If humans could enter the spider’s world, they could learn about web construction, arachnid behavior and more. Today, scientists report that they have translated the structure of a web into music, which could have applications ranging from better 3D printers to cross-species communication and otherworldly musical compositions.
The researchers will present their results today at the spring meeting of the American Chemical Society (ACS). ACS Spring 2021 is being held online April 5-30 [2021]. Live sessions will be hosted April 5-16, and on-demand and networking content will continue through April 30 [2021]. The meeting features nearly 9,000 presentations on a wide range of science topics.
“The spider lives in an environment of vibrating strings,” says Markus Buehler, Ph.D., the project’s principal investigator, who is presenting the work. “They don’t see very well, so they sense their world through vibrations, which have different frequencies.” Such vibrations occur, for example, when the spider stretches a silk strand during construction, or when the wind or a trapped fly moves the web.
Buehler, who has long been interested in music, wondered if he could extract rhythms and melodies of non-human origin from natural materials, such as spider webs. “Webs could be a new source for musical inspiration that is very different from the usual human experience,” he says. In addition, by experiencing a web through hearing as well as vision, Buehler and colleagues at the Massachusetts Institute of Technology (MIT), together with collaborator Tomás Saraceno at Studio Tomás Saraceno, hoped to gain new insights into the 3D architecture and construction of webs.
With these goals in mind, the researchers scanned a natural spider web with a laser to capture 2D cross-sections and then used computer algorithms to reconstruct the web’s 3D network. The team assigned different frequencies of sound to strands of the web, creating “notes” that they combined in patterns based on the web’s 3D structure to generate melodies. The researchers then created a harp-like instrument and played the spider web music in several live performances around the world.
The team also made a virtual reality setup that allowed people to visually and audibly “enter” the web. “The virtual reality environment is really intriguing because your ears are going to pick up structural features that you might see but not immediately recognize,” Buehler says. “By hearing it and seeing it at the same time, you can really start to understand the environment the spider lives in.”
To gain insights into how spiders build webs, the researchers scanned a web during the construction process, transforming each stage into music with different sounds. “The sounds our harp-like instrument makes change during the process, reflecting the way the spider builds the web,” Buehler says. “So, we can explore the temporal sequence of how the web is being constructed in audible form.” This step-by-step knowledge of how a spider builds a web could help in devising “spider-mimicking” 3D printers that build complex microelectronics. “The spider’s way of ‘printing’ the web is remarkable because no support material is used, as is often needed in current 3D printing methods,” he says.
In other experiments, the researchers explored how the sound of a web changes as it’s exposed to different mechanical forces, such as stretching. “In the virtual reality environment, we can begin to pull the web apart, and when we do that, the tension of the strings and the sound they produce change. At some point, the strands break, and they make a snapping sound,” Buehler says.
The team is also interested in learning how to communicate with spiders in their own language. They recorded web vibrations produced when spiders performed different activities, such as building a web, communicating with other spiders or sending courtship signals. Although the frequencies sounded similar to the human ear, a machine learning algorithm correctly classified the sounds into the different activities. “Now we’re trying to generate synthetic signals to basically speak the language of the spider,” Buehler says. “If we expose them to certain patterns of rhythms or vibrations, can we affect what they do, and can we begin to communicate with them? Those are really exciting ideas.”
You can go here for the April 12, 2021 ‘Making music from spider webs’ ACS press conference’ it runs about 30 mins. and you will hear some ‘spider music’ played.
Getting back to the image and spider webs in general, we are most familiar with orb webs (in the part of Canada where I from if nowhere else), which look like spirals and are 2D. There are several other types of webs some of which are 3D, like tangle webs, also known as cobwebs, funnel webs and more. See this March 18, 2020 article “9 Types of Spider Webs: Identification + Pictures & Spiders” by Zach David on Beyond the Treat for more about spiders and their webs. If you have the time, I recommend reading it.
I’ve been following Buehler’s spider web/music work for close to ten years now; the latest previous posting is an October 23, 2019 posting where you’ll find a link to an application that makes music from proteins (spider webs are made up of proteins; scroll down about 30% of the way; it’s in the 2nd to last line of the quoted text about the embedded video).
Here is a video (2 mins. 17 secs.) of a spider web music performance that Buehler placed on YouTube,
Feb 3, 2021
Markus J. Buehler
Spider’s Canvas/Arachonodrone show excerpt at Palais de Tokyo, Paris, on November 2018. Video by MIT CAST. More videos can be found on www.arachnodrone.com. The performance was commissioned by Studio Tomás Saraceno (STS), in the context of Saraceno’s carte blanche exhibition, ON AIR. Spider’s Canvas/Arachnodrone was performed by Isabelle Su and Ian Hattwick on the spider web instrument, Evan Ziporyn on the EWI (Electronic Wind Instrument), and Christine Southworth on the guitar and EBow (Electronic Bow)
Spider’s Canvas / Arachnodrone is inspired by the multifaceted work of artist Tomas Saraceno, specifically his work using multiple species of spiders to make sculptural webs. Different species make very different types of webs, ranging not just in size but in design and functionality. Tomas’ own web sculptures are in essence collaborations with the spiders themselves, placing them sequentially over time in the same space, so that the complex, 3-dimensional sculptural web that results is in fact built by several spiders, working together.
Meanwhile, back among the humans at MIT, Isabelle Su, a Course 1 doctoral student in civil engineering, has been focusing on analyzing the structure of single-species spider webs, specifically the ‘tent webs’ of the cyrtophora citricola, a tropical spider of particular interest to her, Tomas, and Professor Markus Buehler. Tomas gave the department a cyrtophora spider, the department gave the spider a space (a small terrarium without glass), and she in turn built a beautiful and complex web. Isabelle then scanned it in 3D and made a virtual model. At the suggestion of Evan Ziporyn and Eran Egozy, she then ported the model into Unity, a VR/game making program, where a ‘player’ can move through it in numerous ways. Evan & Christine Southworth then worked with her on ‘sonifying’ the web and turning it into an interactive virtual instrument, effectively turning the web into a 1700-string resonating instrument, based on the proportional length of each individual piece of silk and their proximity to one another. As we move through the web (currently just with a computer trackpad, but eventually in a VR environment), we create a ‘sonic biome’: complex ‘just intonation’ chords that come in and out of earshot according to which of her strings we are closest to. That part was all done in MAX/MSP, a very flexible high level audio programming environment, which was connected with the virtual environment in Unity. Our new colleague Ian Hattwick joined the team focusing on sound design and spatialization, building an interface that allowed him the sonically ‘sculpt’ the sculpture in real time, changing amplitude, resonance, and other factors. During this performance at Palais de Tokyo, Isabelle toured the web – that’s what the viewer sees – while Ian adjusted sounds, so in essence they were together “playing the web.” Isabelle provides a space (the virtual web) and a specific location within it (by driving through), which is what the viewer sees, from multiple angles, on the 3 scrims. The location has certain acoustic potentialities, and Ian occupies them sonically, just as a real human performer does in a real acoustic space. A rough analogy might be something like wandering through a gothic cathedral or a resonant cave, using your voice or an instrument at different volumes and on different pitches to find sonorous resonances, echoes, etc. Meanwhile, Evan and Christine are improvising with the web instrument, building on Ian’s sound, with Evan on EWI (Electronic Wind Instrument) and Christine on electric guitar with EBow.
For the visuals, Southworth wanted to create the illusion that the performers were actually inside the web. We built a structure covered in sharkstooth scrim, with 3 projectors projecting in and through from 3 sides. Southworth created images using her photographs of local Lexington, MA spider webs mixed with slides of the scan of the web at MIT, and then mixed those images with the projection of the game, creating an interactive replica of Saraceno’s multi-species webs.
If you listen to the press conference, you will hear Buehler talk about practical applications for this work in materials science.
Part 1 covered some of the more formal aspects science culture in Canada, such as science communication education programmes, mainstream media, children’s science magazines, music, etc. Part 2 covered science festivals, art/sci or sciart (depending on who’s talking, informal science get togethers such ‘Cafe Sccientifque’, etc.
This became a much bigger enterprise than I anticipated and so part 3 is stuffed with the do-it-yourself (DIY) biology movement in Canada, individual art/sci or lit/sci projects, a look at what the mathematicians have done and are doing, etc. But first there’s the comedy.
Comedy, humour, and science
Weirdly, Canadians like to mix their science fiction (scifi) movies with humour. (I will touch on more scifi later in this post but it’s too big a topic to cover inadequately, let alone adequately, in this review.) I post as my evidence of the popularity of comedy science fiction films, this from the Category: Canadian science fiction films Wikipedia webpage,
As you see, comedy science fiction is the second most populated category. Also, the Wikipedia time frame is much broader than mine but I did check one Canadian science fiction comedy film, Bang Bang Baby, a 2014 film, which, as it turns out, is also a musical.
The 2019 iteration of the Vancouver Podcast Festival included the podcast duo, Daniel Chai and Jeff Porter, behind The Fear of Science (which seems to be a science podcast of a humourous bent). They participated in a live https://www.vanpodfest.ca/event/live-podcast-fear-science-vs-vancolour podcast titled, Live Podcast: Fear of Science vs. This is VANCOLOUR.
Daniel Chai is a Vancouver-based writer, comedian, actor and podcaster. He is co-host of The Fear of Science podcast, which combines his love of learning with his love of being on a microphone. Daniel is also co-founder of The Fictionals Comedy Co and the creator of Improv Against Humanity, and teaches improv at Kwantlen Polytechnic University. He is very excited to be part of Vancouver Podcast Festival, and thanks everyone for listening!
Jeff is the producer and co-host of The Fear of Science. By day, he is a graphic designer/digital developer [according to his LinkedIn profile, he works at Science World], and by night he is a cosplayer, board gamer and full-time geek. Jeff is passionate about all things science, and has been working in science communication for over 4 years. He brings a general science knowledge point of view to The Fear of Science.
Here’s more about The Fear of Science from its homepage (where you will also find links to their podcasts),
A podcast that brings together experts and comedians for an unfiltered discussion about complicated and sometimes controversial science fears in a fun and respectful way.
This podcast seems to have taken life in August 2018.(Well, that’s as far back as the Archived episodes stretch on the website.)
This is Vancolour is a podcast hosted by Mo Amir and you will find this description on the website,
THIS IS A PODCAST ABOUT VANCOUVER AND THE PEOPLE WHO MAKE THIS CITY COLOURFUL
Cartoonist, writer, and educator, Raymond Nakamura produces work for Telus Science World and the Science Borealis science aggregator. His website is known as Raymond’s Brain features this image,
Getting an EEG to test whether my brain works. It does! [downloaded from http://www.raymondsbrain.com/biocontact]
Much has been happening on this front. First for anyone unfamiliar with do-it-yourself biology, here’s more from its Wikipedia entry,
Do-it-yourself biology (DIY biology, DIY bio) is a growing biotechnological social movement in which individuals, communities, and small organizations study biology and life science using the same methods as traditional research institutions. DIY biology is primarily undertaken by individuals with extensive research training from academia or corporations, who then mentor and oversee other DIY biologists with little or no formal training. This may be done as a hobby, as a not-for-profit endeavour for community learning and open-science innovation, or for profit, to start a business.
A January 21, 2020 posting here listed the second Canadian DIY Biology Summit organized by the Public Health Agency of Canada (PHAC). It was possible to attend virtually from any part of Canada. The first meeting was in 2016 (you can see the agenda here). You’ll see in the agenda for the 2nd meeting in 2020 that there have been a few changes as groups rise into and fall out of existence.
From the 2020 agenda, here’s a list representing the players in Canada’s DIYbio scene,
Most of these organizations (e.g., Victoria Makerspace, Synbiota, Bricobio, etc.) seem to be relatively new (founded in 2009 or later) which is quite exciting to think about. This March 13, 2016 article in the Vancouver Observer gives you a pretty good overview of the DIY biology scene in Canada at the time while providing a preview of the then upcoming first DIY Biology summit.
*The Open Science Network in Vancouver was formerly known as DIYbio YVR. I’m not sure when the name change occurred but this July 17, 2018 article by Emily Ng for The Ubyssey (a University of British Columbia student newspaper) gives a little history,
…
In 2009, a group of UBC students and staff recognized these barriers and teamed up to democratize science, increase its accessibility and create an interdisciplinary platform for idea exchange. They created the Open Science Network (OSN).
The Open Science Network is a non-profit society that serves the science and maker community through education, outreach and the provision of space. Currently, they run an open community lab out of the MakerLabs space on East Cordova and Main street, which is a compact space housing microscopes, a freezer, basic lab equipment and an impressive amount of activity.
The lab is home to a community of citizen scientists, professional scientists, artists, designers and makers of all ages who are pursuing their own science projects.
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Members who are interested in lab work can receive some training in “basic microbiology techniques like pipetting, growing bacteria, using the Polymerase Chain Reaction machine (PCR) [to amplify DNA] and running gels [through a gel ectrophoresis machine to separate DNA fragments by size] from Scott Pownall, a PhD graduate from UBC and the resident microbiologist,” said Wong [ Wes Wong, a staff member of UBC Botany and a founding member of OSN].
The group has also made further efforts to serve their members by offering more advanced synthetic biology classes and workshops at their lab.
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There is another organization called ‘Open Science Network’ (an ethnobiology group and not part of the Vancouver organization). Here is a link to the Vancouver-based Open Science Network (a community science lab) where they provide further links to all their activities including a regular ‘meetup’.
The word
I have poetry, a book, a television adaptation, three plays with mathematics and/or physics themes and more.
Poetry
In 2012 there was a night of poetry readings in Vancouver. What made it special was that five poets had collaborated with five scientists (later amended to four scientists and a landscape architect) according to my December 4, 2012 posting. The whole thing was conceptualized and organized by Aileen Penner who went on to produce a chapbook of the poetry. She doesn’t have any copies available currently but you can contact her on her website’s art/science page if you are interested in obtaining a copy. She doesn’t seem to have organized any art/science projects since. For more about Aileen Penner who is a writer and poet, go to her website here.
The Banff International Research Station (BIRS) it’s all about the mathematics) hosted a workshop for poets and mathematicians way back in 2011. I featured it (Mathematics: Muse, Maker, and Measure of the Arts) after the fact in my January 9, 2012 posting (scroll down about 30% of the way). If you have the time, do click on my link to Nassif Ghoussoub’s post on his blog (Piece of Mind) about mathematicians, poetry, and the arts. It’s especially interesting in retrospect as he is now the executive director for BIRS, which no longer seems to have workshops that meld any of the arts with mathematics, and science.
One of the guests at that 2011 meeting was Alice Major, former poet laureate for Edmonton and the author of a 2011 book titled, Intersecting Sets: A Poet Looks at Science.
That sadly seems to be it for poetry and the sciences, including mathematics. If you know of any other poetry/science projects or readings, etc. in Canada during the 2010-9 decade, please let me know in the comments.
Books
Karl Schroeder, a Canadian science fiction author, has written many books but of particular interest here are two futuristic novels for the Canadian military.The 2005 novel, Crisis in Zefra, doesn’t fit the time frame I’ve established for this review but the the 2014 novel, Crisis in Urla (scroll down) fits in nicely. His writing is considered ‘realistic’ science fiction in that it’s based on science research and his work is also associated with speculative realism (from his Wikipedia entry; Note: Links have been removed),
Karl Schroeder (born September 4, 1962) is a Canadianscience fiction author. His novels present far-future speculations on topics such as nanotechnology, terraforming, augmented reality, and interstellar travel, and are deeply philosophical.
The other author I’m mentioning here is Margaret Atwood. The television adaptation of her book, ‘The Handmaid’s Tale’ has turned a Canadian literary superstar into a supernova (an exploding star whose luminosity can be the equivalent of an entire galaxy). In 2019, she won the Booker Prize, for the second time for ‘The Testaments’ (a followup to ‘The Handmaid’s Tale’), sharing it with Bernardine Evaristo and her book ‘Girl, Woman, Other’. Atwood has described her work (The Handmaid’s Tale, and others) as speculative fiction rather than science fiction. For me, she bases her speculation on the social sciences and humanities, specifically history (read her Wikipedia entry for more).
In 2017 with the television adaptation of ‘The Handmaid’s Tale’, Atwood’s speculative fiction novel became a pop culture phenomenon. Originally published in 1985, the novel was also adapted for a film in 1990 and for an opera in 2000 before it came to television, according to its Wikipedia entry.
There’s a lot more out there, Schroeder and Atwood are just two I’ve stumbled across.
Theatre
I have drama, musical comedy and acting items.
Drama
Pi Theatre’s (Vancouver) mathematically-inclined show, ‘Long Division‘, ran in April 2017 and was mentioned in my April 20, 2017 posting (scroll down about 50% of the way).
This theatrical performance of concepts in mathematics runs from April 26 – 30, 2017 (check here for the times as they vary) at the Annex at 823 Seymour St. From the Georgia Straight’s April 12, 2017 Arts notice,
“Mathematics is an art form in itself, as proven by Pi Theatre’s number-charged Long Division. This is a “refreshed remount” of Peter Dickinson’s ambitious work, one that circles around seven seemingly unrelated characters (including a high-school math teacher, a soccer-loving imam, and a lesbian bar owner) bound together by a single traumatic incident. Directed by Richard Wolfe, with choreography by Lesley Telford and musical score by Owen Belton, it’s a multimedia, movement-driven piece that has a strong cast. … “
You can read more about the production here. As far as I’m aware, there are no upcoming show dates.
There seems to be some sort of affinity between theatre and mathematics, I recently featured (January 3, 2020 posting) a theatrical piece by Hannah Moscovitch titled, ‘Infinity‘, about time, physics, math and more. It had its first production in Toronto in 2015.
John Mighton, a playwright and mathematician, wrote ‘The Little Years’ which has been produced in both Vancouver and Toronto. From a May 9, 2005 article by Kathleen Oliver for the Georgia Straight,
The Little Years is a little jewel of a play: small but multifaceted, and beautifully crafted.
John Mighton’s script gives us glimpses into different stages in the life of Kate, a woman whose early promise as a mathematician is cut short. At age 13, she’s a gifted student whose natural abilities are overlooked by 1950s society, which has difficulty conceiving of women as scientists. Instead, she’s sent to vocational school while her older brother, William, grows up to become one of the most widely praised poets of his generation.
John Mighton is a successful playwright and mathematician, yet at times in his life, he’s struggled with doubt. However, he also learned there was hope, and that’s the genesis of The Little Years, which opens at the Tarragon Theatre on Nov. 16 and runs to Dec. 16 [2012].
In keeping (more or less) with this subsection’s theme ‘The Word’, Mighton has recently had a new book published, ‘All Things Being Equal: Why Math is the Key to a Better World’, according to a January 24, 2020 article (online version) by Jamie Portman for Postmedia,
It’s more than two decades since Canadian mathematician and playwright John Mighton found himself playing a small role in the film, Good Will Hunting. What he didn’t expect when he took on the job was that he would end up making a vital contribution to a screenplay that would go on to win an Oscar for its writers, Ben Affleck and Matt Damon.
What happened on that occasion tells you a great deal about Mighton’s commitment to the belief that society grossly underestimates the intellectual capacity of human beings — a belief reiterated with quiet eloquence in his latest book, All Things Being Equal.
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Mighton loved the experience but as shooting continued he became troubled over his involvement in a movie that played “heavily on the idea that geniuses like Will are born and not made.” This was anathema to his own beliefs as a mathematician and he finally summoned up the courage to ask Affleck and Damon if he could write a few extra lines for his character. This speech was the result: “Most people never get the chance to see how brilliant they can be. They don’t find teachers who believe in them. They get convinced they’re stupid.”
At a time of growing controversy across Canada over the teaching of mathematics in school and continuing evidence of diminishing student results, Mighton continues to feel gratitude to the makers of Good Will Hunting for heeding his concerns. [I will be writing a post about the latest PISA scores where Canadian students have again slipped in their mathematics scores.]
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Mighton is on the phone from from Toronto, his voice soft-spoken but still edged with fervour. He pursues two successful careers — as an award-winning Canadian playwright and as a renowned mathematician and philosopher who has devoted a lifetime to developing strategies that foster the intellectual potential of all children through learning math. But even as he talks about his 2001 founding of JUMP Math, a respected charity that offers a radical alternative to conventional teaching of the subject, he’s anxious to remind you that he’s a guy who almost failed calculus at university and who once struggled to overcome his “own massive math anxiety.”
…
You can find out more about John Mighton in his Wikipedia entry (mostly about his academic accomplishments) and on the JUMP Math website (better overall biography).
Musical Comedy
It’s called ‘Math Out Loud’ and was first mentioned here in a January 9, 2012 posting (the same post also featured the BIRS poetry workshop),
“When Mackenzie Gray talks about the way Paul McCartney used a recursive sequence to make the song “I Want You (She’s So Heavy)” seem to last forever, you realize that part of the Beatles’ phenomenal success might have sprung from McCartney’s genius as a mathematician.
When Roger Kemp draws on a napkin to illustrate that you just have to change the way you think about numbers to come up with a binary code for pi (as in 3.14 ad infinitum), you get a sense that math can actually be a lot of fun.”
Produced by MITACS which in 2012 was known as ‘Mathematics of Information Technology and Complex Systems’, a not-for-profit research organization, the musical went on tour in the Fall of 2012 (according to my September 7, 2012 posting). Unusually, I did not embed the promotional trailer for this 2012 musical so, here it is now,
Since 2012, Mitacs has gone through some sort of rebranding process and it’s now described as a nonprofit national research organization. For more you can read its Wikipedia entry or go to its website.
Acting and storytelling
It turns out there was an acting class (five sessions) for scientists at the University of Calgary in 2017. Here’s more from the course’s information sheet,
Act Your Science: Improve Your Communication Skills with Training in Improvisation 2 hours a session, 5 sessions, every Wednesday starting November 14 [2017] …
Dr. Jeff Dunn, Faculty of Graduate Studies, Graduate Students Association, the Canadian Science Writers Association [also known as Science Writers and Communicators of Canada] and the Loose Moose Theatre have teamed together to provide training in a skill which will be useful where ever your career takes you.
The goal of this project is to improve the science communication skills of graduate students in science fields. We will improve your communication through the art of training in improvisation. Training will help with speech and body awareness. Improvisation will provide life‐long skills in communication, in a fun interactive environment.
For many years, Alan Alda, a well-known actor (originally of the “MASH” television series fame), has applied his acting skills and improvisation training to help scientists improve their communication. He developed the Alan Alda Centre for Communicating Science at Stony Brook University.
…
The training will involve five 2hr improvisation workshop sessions led by one of Canada’s top professional improvisation trainers, Dennis Cahill, the Artistic Director from Loose Moose Theatre. Dennis has an international reputation for developing the theatrical style of improvisation. Training involves a lot of moving around (and possibly rolling on the floor!) so dress casually. Be prepared to release your inhibitions!
…
The information sheet includes a link to this University of Chicago video (posted on Youtube February 24, 2014) of actor Alan Alda discussing science communication,
As for the storytelling, we’re back at the University of Calgary. A student video and storytelling workshop and contest (Innovation Untold) was held on Tuesday, February 4, 2020. Here’s more from the University of Calgary event page for Storytelling Workshop: Do photos and videos have voices?,
…
About the speaker:
Victoria Bouvier, a Michif-Metis woman, is of the Red River Settlement and Boggy Creek, Manitoba, and born and raised in Calgary. She is an Assistant professor in Indigenous Studies at Mount Royal University and a doctoral candidate in Educational Research [emphasis mine] at the University of Calgary. Her research is exploring how Michif/Métis people, born and raised in urban environments, practice and express their self-understandings, both individually and collectively through using an Indigenous oral system and visual media as methodology.
In a technology-laden society, people are capturing millions of photographs and videos that document their lived experiences, followed by uploading them to social media sites. As mass amounts of media is being shared each day, the question becomes: are we utilizing photos and videos to derive meaning from our everyday lived experiences, while settling in to a deeper sense of our self-in-relation?
This session will explore how photos and videos, positioned within an Indigenous oral system, are viewed and interacted with as a third perspective in the role of storytelling.
Finally, h/t to Jennifer Bon Bernard’s April 19, 2017 article (reposted Dec. 11, 2019) about Act Your Science for the Science Writers and Communicators blog. The original date doesn’t look right to me but perhaps she participated in a pilot project.
Neuroscience, science policy, and science advice
The end of this part is almost in sight
Knitting in Toronto and drawings in Vancouver (neuroscience)
In 2017, Toronto hosted a neuroscience event which combined storytelling and knitting (from my October 12, 2017 posting (Note: the portion below is an excerpt from an ArtSci Salon announcement),
With NARRATING NEUROSCIENCE we plan to initiate a discussion on the role and the use of storytelling and art (both in verbal and visual forms) to communicate abstract and complex concepts in neuroscience to very different audiences, ranging from fellow scientists, clinicians and patients, to social scientists and the general public. We invited four guests to share their research through case studies and experiences stemming directly from their research or from other practices they have adopted and incorporated into their research, where storytelling and the arts have played a crucial role not only in communicating cutting edge research in neuroscience, but also in developing and advancing it.
The ArtSci Salon folks also announced this (from the Sept. 25, 2017 ArtSci Salon announcement; received via email),
ATTENTION ARTSCI SALONISTAS AND FANS OF ART AND SCIENCE!! CALL FOR KNITTING AND CROCHET LOVERS!
In addition to being a PhD student at the University of Toronto, Tahani Baakdhah is a prolific knitter and crocheter and has been the motor behind two successful Knit-a-Neuron Toronto initiatives. We invite all Knitters and Crocheters among our ArtSci Salonistas to pick a pattern (link below) and knit a neuron (or 2! Or as many as you want!!)
BRING THEM TO OUR OCTOBER 20 ARTSCI SALON! Come to the ArtSci Salon and knit there!
That link to the patterns is still working.
Called “The Beautiful Brain” and held in the same time frame as Toronto’s neuro event, Vancouver hosted an exhibition of Santiago Ramon y Cajal’s drawings from September 5 to December 3, 2017. In concert with the exhibition, the local ‘neuro’ community held a number of outreach events. Here’s what I had in my September 11, 2017 posting where I quoted from the promotional material for the exhibition,
…
The Beautiful Brain is the first North American museum exhibition to present the extraordinary drawings of Santiago Ramón y Cajal (1852–1934), a Spanish pathologist, histologist and neuroscientist renowned for his discovery of neuron cells and their structure, for which he was awarded the Nobel Prize in Physiology and Medicine in 1906. Known as the father of modern neuroscience, Cajal was also an exceptional artist. He combined scientific and artistic skills to produce arresting drawings with extraordinary scientific and aesthetic qualities.
A century after their completion, Cajal’s drawings are still used in contemporary medical publications to illustrate important neuroscience principles, and continue to fascinate artists and visual art audiences. …
Pictured: Santiago Ramón y Cajal, injured Purkinje neurons, 1914, ink and pencil on paper. Courtesy of Instituto Cajal (CSIC).
From Vancouver, the exhibition traveled to a gallery in New York City and then onto the Massachusetts Institute of Technology (MIT).
Mehrdad Hariri has done a an extraordinary job as its founder and chief executive officer. The CSPC has developed from a single annual conference to an organization that hosts different events throughout the year and publishes articles and opinion pieces on Canadian science policy and has been instrumental in the development of a Canadian science policy community.
The magnitude of Hariri’s accomplishment becomes clear when reading J.w. Grove’s [sic] article, Science Policy, in The Canadian Encyclopedia and seeing that the most recent reports on a national science policy seem to be the Science Council’s (now defunct) 4th report in 1968, Towards a National Science Policy in Canada, the OECD’s (Organization for Economic Cooperation and Development) 1969 Review of [Canada’s] Science Policy, and 3 reports from the Senate’s Lamontagne Committee (Special Committee on Science Policy). Grove’s article takes us only to 1988 but I have been unable to find any more recent reports focused on a national science policy for Canada. (If you have any information about a more recent report, please do let me know in the comments.)
A November 5, 2019 piece (#VoteScience: lessons learned and building science advocacy beyond the election cycle) on the CSPC website further illustrates how the Canadian science policy community has gained ground (Note: Links have been removed),
… on August 8, 2019, a coalition of Canadian science organizations and student groups came together to launch the #VoteScience campaign: a national, non-partisan effort to advocate for science in the federal elections, and make science an election issue.
Specifically, we — aka Evidence for Democracy, Science & Policy Exchange (SPE), and the Toronto Science Policy Network (TSPN) [emphases mine] — built a collection of tools and resources to empower Canadian scientists and science supporters to engage with their local candidates on science issues and the importance of evidence-informed decision-making. Our goal was to make it easy for as many Canadians as possible to engage with their candidates — and they did.
Over the past three months, our #VoteScience portal received over 3,600 visitors, including 600 visitors who used our email form to reach out directly to their local candidates. Collectively, we took #VoteScience selfies, distributed postcards to supporters across Canada, and even wrote postcards to every sitting Member of Parliament (in addition to candidates from all parties in each of our own ridings). Also of note, we distributed a science policy questionnaire to the federal parties, to help better inform Canadians about where the federal parties stand on relevant science issues, and received responses from all but one party. We’ve also advocated for science through various media outlets, including commenting for articles appearing in The Narwhal and Nature News, and penning op-eds for outlets such as the National Observer, University Affairs, Le Devoir, and Découvrir.
Prior to SPIN, the Council of Canadian Academies (CCA; more about them in part 4), issued a 2017 report titled, Science Policy: Considerations for Subnational Governments. The report was the outcome of a 2016 CCA workshop originally titled, Towards a Science Policy in Alberta. I gather the scope broadened.
Interesting trajectory, yes?
Chief Science advisors/scientists
In September 2017, the Canadian federal government announced that a Chief Science Advisor, Dr. Mona Nemer, had been appointed. I have more about the position and Dr. Nemer in my September 26, 2017 posting. (Prior to Dr. Nemer’s appointment a previous government had discontinued a National Science Advisor position that existed from 2004 to 2008.)
The Office of the Chief Science Advisor released it first annual report in 2019 and was covered here in a March 19, 2019 posting.
Québec is the only province (as far as I know) to have a Chief Scientist, Rémi Quirion who was appointed in 2011.
Onto Part 4 where you’ll find we’ve gone to the birds and more.
*The Canadian Science Policy Centre (CSPC) section was written sometime in February 2020. I believe they are planning to publish an editorial piece I submitted to them on April 20, 202 (in other words, before this post was published) in response to their call for submissions (see my April 1, 2020 post for details about the call). In short, I did not praise the organization with any intention of having my work published by them. (sigh) Awkward timing.
Cloaking is one of the most eye-catching technologies in sci-fi movies. In two 2018 Marvel films, Black Panther and Avengers: Infinity War, Black Panther conceals his country Wakanda, a technologically advanced African nation, from the outside world using the metal vibranium.
However, in the real world, if you want to hide something, you need to deceive not only the eyes, but also the ears, especially in the underwater environment.
Recently, a research team led by Prof. YANG Jun from the Institute of Acoustics (IOA) of the Chinese Academy of Sciences designed and fabricated a 3D underwater acoustic carpet cloak (UACC) using transformation acoustics.
The research was published online in Applied Physics Letters on June 1 [2018].
Like a shield, the carpet cloak is a material shell that can reflect waves as if the waves were reflecting off a planar surface. Hence, the cloaked target becomes undetectable to underwater detection instruments like sonar.
Using transformation acoustics, the research team first finished the 2D underwater acoustic carpet cloak with metamaterial last year (Scientific Reports, April 6, 2017). However, this structure works only in two dimensions, and becomes immediately detectable when a third dimension is introduced.
To solve this problem, YANG Jun and his IOA team combined transformation acoustics with a reasonable scaling factor, worked out the parameters, and redesigned the unit cell of the 2D cloak. They designed the 3D underwater acoustic carpet cloak and then proposed a fabrication and assembly method to manufacture it. The 3D cloak can hide an object from top to bottom and deal with complex situations, such as acoustic detection in all directions.
The 3D underwater acoustic carpet cloak is a pyramid comprising eight triangular pyramids; each triangular pyramid is composed of 92 steel strips using a rectangle lattice, similar to a wafer biscuit. More vividly, if we remove the core from a big solid pyramid, we can hide something safely in the hollow space left.
“To make a 3D underwater acoustic carpet cloak, researchers needed to construct the structure with 2D period, survey the influence of the unit cell’s resonance, examine the camouflage effect at the ridge of the sample, and other problems. In addition, the fabrication and assembly of the 3D device required more elaborate design. The extension of the UACC from 2D to 3D represents important progress in applied physics,” said YANG.
In experimental tests, a short Gaussian pulse propagated towards the target covered with the carpet cloak, and the waves backscattered toward their origin. The cloaked object successfully mimicked the reflecting surface and was undetectable by sound detection. Meanwhile, the measured acoustic pressure fields from the vertical view demonstrated the effectiveness of the designed 3D structure in every direction.
“As the next step, we will try to make the 3D underwater acoustic carpet cloak smaller and lighter,” said YANG.
Funding for this research came from the National Natural Science Foundation of China (Grant No.11304351, 1177021304), the Youth Innovation Promotion Association of CAS (Grant No. 2017029), and the IACAS Young Elite Researcher Project (Grant No. QNYC201719).
Prof. YANG Jun and Dr. JIA Han led the research team from the Institute of Acoustics (IOA) of the Chinese Academy of Sciences. Prof. YANG Jun engages in research on sound, vibration and signal processing, and especially sound field control and array signal processing. They also work on other devices based on metamaterial in order to manipulate the propagation of sound waves.
A model of the device,
Caption: This is a model and photograph of the 3D underwater acoustic carpet cloak composed of over 700 steel strips. Credit: IOA
Kudos to anyone who recognized the reference to Pauline Kael (she changed film criticism forever) and her book “I Lost it at the Movies.” Of course, her book title was a bit of sexual innuendo, quite risqué for an important film critic in 1965 but appropriate for a period (the 1960s) associated with a sexual revolution. (There’s more about the 1960’s sexual revolution in the US along with mention of a prior sexual revolution in the 1920s in this Wikipedia entry.)
The title for this commentary is based on an anecdote from Dr. Andrew Maynard’s (director of the Arizona State University [ASU] Risk Innovation Lab) popular science and technology book, “Films from the Future: The Technology and Morality of Sci-Fi Movies.”
The ‘title-inspiring’ anecdote concerns Maynard’s first viewing of ‘2001: A Space Odyssey, when as a rather “bratty” 16-year-old who preferred to read science fiction, he discovered new ways of seeing and imaging the world. Maynard isn’t explicit about when he became a ‘techno nerd’ or how movies gave him an experience books couldn’t but presumably at 16 he was already gearing up for a career in the sciences. That ‘movie’ revelation received in front of a black and white television on January 1,1982 eventually led him to write, “Films from the Future.” (He has a PhD in physics which he is now applying to the field of risk innovation. For a more detailed description of Dr. Maynard and his work, there’s his ASU profile webpage and, of course, the introduction to his book.)
The book is quite timely. I don’t know how many people have noticed but science and scientific innovation is being covered more frequently in the media than it has been in many years. Science fairs and festivals are being founded on what seems to be a daily basis and you can now find science in art galleries. (Not to mention the movies and television where science topics are covered in comic book adaptations, in comedy, and in standard science fiction style.) Much of this activity is centered on what’s called ’emerging technologies’. These technologies are why people argue for what’s known as ‘blue sky’ or ‘basic’ or ‘fundamental’ science for without that science there would be no emerging technology.
Films from the Future
Isn’t reading the Table of Contents (ToC) the best way to approach a book? (From Films from the Future; Note: The formatting has been altered),
Table of Contents Chapter One
In the Beginning 14
Beginnings 14
Welcome to the Future 16
The Power of Convergence 18
Socially Responsible Innovation 21
A Common Point of Focus 25
Spoiler Alert 26 Chapter Two
Jurassic Park: The Rise of Resurrection Biology 27
When Dinosaurs Ruled the World 27
De-Extinction 31
Could We, Should We? 36
The Butterfly Effect 39
Visions of Power 43 Chapter Three
Never Let Me Go: A Cautionary Tale of Human Cloning 46
Sins of Futures Past 46
Cloning 51
Genuinely Human? 56
Too Valuable to Fail? 62 Chapter Four
Minority Report: Predicting Criminal Intent 64
Criminal Intent 64
The “Science” of Predicting Bad Behavior 69
Criminal Brain Scans 74
Machine Learning-Based Precognition 77
Big Brother, Meet Big Data 79 Chapter Five
Limitless: Pharmaceutically-enhanced Intelligence 86
A Pill for Everything 86
The Seduction of Self-Enhancement 89
Nootropics 91
If You Could, Would You? 97
Privileged Technology 101
Our Obsession with Intelligence 105 Chapter Six
Elysium: Social Inequity in an Age of Technological
Extremes 110
The Poor Shall Inherit the Earth 110
Bioprinting Our Future Bodies 115
The Disposable Workforce 119
Living in an Automated Future 124 Chapter Seven
Ghost in the Shell: Being Human in an
Augmented Future 129
Through a Glass Darkly 129
Body Hacking 135
More than “Human”? 137
Plugged In, Hacked Out 142
Your Corporate Body 147 Chapter Eight
Ex Machina: AI and the Art of Manipulation 154
Plato’s Cave 154
The Lure of Permissionless Innovation 160
Technologies of Hubris 164
Superintelligence 169
Defining Artificial Intelligence 172
Artificial Manipulation 175 Chapter Nine
Transcendence: Welcome to the Singularity 180
Visions of the Future 180
Technological Convergence 184
Enter the Neo-Luddites 190
Techno-Terrorism 194
Exponential Extrapolation 200
Make-Believe in the Age of the Singularity 203 Chapter Ten
The Man in the White Suit: Living in a Material World 208
There’s Plenty of Room at the Bottom 208
Mastering the Material World 213
Myopically Benevolent Science 220
Never Underestimate the Status Quo 224
It’s Good to Talk 227 Chapter Eleven
Inferno: Immoral Logic in an Age of
Genetic Manipulation 231
Decoding Make-Believe 231
Weaponizing the Genome 234
Immoral Logic? 238
The Honest Broker 242
Dictating the Future 248 Chapter Twelve
The Day After Tomorrow: Riding the Wave of
Climate Change 251
Our Changing Climate 251
Fragile States 255
A Planetary “Microbiome” 258
The Rise of the Anthropocene 260
Building Resiliency 262
Geoengineering the Future 266 Chapter Thirteen
Contact: Living by More than Science Alone 272
An Awful Waste of Space 272
More than Science Alone 277
Occam’s Razor 280
What If We’re Not Alone? 283 Chapter Fourteen
Looking to the Future 288
Acknowledgments 293
The ToC gives the reader a pretty clue as to where the author is going with their book and Maynard explains how he chose his movies in his introductory chapter (from Films from the Future),
“There are some quite wonderful science fiction movies that didn’t make the cut because they didn’t fit the overarching narrative (Blade Runner and its sequel Blade Runner 2049, for instance, and the first of the Matrix trilogy). There are also movies that bombed with the critics, but were included because they ably fill a gap in the bigger story around emerging and converging technologies. Ultimately, the movies that made the cut were chosen because, together, they create an overarching narrative around emerging trends in biotechnologies, cybertechnologies, and materials-based technologies, and they illuminate a broader landscape around our evolving relationship with science and technology. And, to be honest, they are all movies that I get a kick out of watching.” (p. 17)
Jurassic Park (Chapter Two)
Dinosaurs do not interest me—they never have. Despite my profound indifference I did see the movie, Jurassic Park, when it was first released (someone talked me into going). And, I am still profoundly indifferent. Thankfully, Dr. Maynard finds meaning and a connection to current trends in biotechnology,
Jurassic Park is unabashedly a movie about dinosaurs. But it’s also a movie about greed, ambition, genetic engineering, and human folly—all rich pickings for thinking about the future, and what could possibly go wrong. (p. 28)
…
What really stands out with Jurassic Park, over twenty-five years later, is how it reveals a very human side of science and technology. This comes out in questions around when we should tinker with technology and when we should leave well enough alone. But there is also a narrative here that appears time and time again with the movies in this book, and that is how we get our heads around the sometimes oversized roles mega-entrepreneurs play in dictating how new tech is used, and possibly abused. These are all issues that are just as relevant now as they were in 1993, and are front and center of ensuring that the technologyenabled future we’re building is one where we want to live, and not one where we’re constantly fighting for our lives. (pp. 30-1)
He also describes a connection to current trends in biotechnology,
De-Extinction
In a far corner of Siberia, two Russians—Sergey Zimov and his son Nikita—are attempting to recreate the Ice Age. More precisely, their vision is to reconstruct the landscape and ecosystem of northern Siberia in the Pleistocene, a period in Earth’s history that stretches from around two and a half million years ago to eleven thousand years ago. This was a time when the environment was much colder than now, with huge glaciers and ice sheets flowing over much of the Earth’s northern hemisphere. It was also a time when humans
coexisted with animals that are long extinct, including saber-tooth cats, giant ground sloths, and woolly mammoths.
The Zimovs’ ambitions are an extreme example of “Pleistocene rewilding,” a movement to reintroduce relatively recently extinct large animals, or their close modern-day equivalents, to regions where they were once common. In the case of the Zimovs, the
father-and-son team believe that, by reconstructing the Pleistocene ecosystem in the Siberian steppes and elsewhere, they can slow down the impacts of climate change on these regions. These areas are dominated by permafrost, ground that never thaws through
the year. Permafrost ecosystems have developed and survived over millennia, but a warming global climate (a theme we’ll come back to in chapter twelve and the movie The Day After Tomorrow) threatens to catastrophically disrupt them, and as this happens, the impacts
on biodiversity could be devastating. But what gets climate scientists even more worried is potentially massive releases of trapped methane as the permafrost disappears.
Methane is a powerful greenhouse gas—some eighty times more effective at exacerbating global warming than carbon dioxide— and large-scale releases from warming permafrost could trigger catastrophic changes in climate. As a result, finding ways to keep it in the ground is important. And here the Zimovs came up with a rather unusual idea: maintaining the stability of the environment by reintroducing long-extinct species that could help prevent its destruction, even in a warmer world. It’s a wild idea, but one that has some merit.8 As a proof of concept, though, the Zimovs needed somewhere to start. And so they set out to create a park for deextinct Siberian animals: Pleistocene Park.9
Pleistocene Park is by no stretch of the imagination a modern-day Jurassic Park. The dinosaurs in Hammond’s park date back to the Mesozoic period, from around 250 million years ago to sixty-five million years ago. By comparison, the Pleistocene is relatively modern history, ending a mere eleven and a half thousand years ago. And the vision behind Pleistocene Park is not thrills, spills, and profit, but the serious use of science and technology to stabilize an increasingly unstable environment. Yet there is one thread that ties them together, and that’s using genetic engineering to reintroduce extinct species. In this case, the species in question is warm-blooded and furry: the woolly mammoth.
The idea of de-extinction, or bringing back species from extinction (it’s even called “resurrection biology” in some circles), has been around for a while. It’s a controversial idea, and it raises a lot of tough ethical questions. But proponents of de-extinction argue
that we’re losing species and ecosystems at such a rate that we can’t afford not to explore technological interventions to help stem the flow.
Early approaches to bringing species back from the dead have involved selective breeding. The idea was simple—if you have modern ancestors of a recently extinct species, selectively breeding specimens that have a higher genetic similarity to their forebears can potentially help reconstruct their genome in living animals. This approach is being used in attempts to bring back the aurochs, an ancestor of modern cattle.10 But it’s slow, and it depends on
the fragmented genome of the extinct species still surviving in its modern-day equivalents.
An alternative to selective breeding is cloning. This involves finding a viable cell, or cell nucleus, in an extinct but well-preserved animal and growing a new living clone from it. It’s definitely a more appealing route for impatient resurrection biologists, but it does mean getting your hands on intact cells from long-dead animals and devising ways to “resurrect” these, which is no mean feat. Cloning has potential when it comes to recently extinct species whose cells have been well preserved—for instance, where the whole animal has become frozen in ice. But it’s still a slow and extremely limited option.
Which is where advances in genetic engineering come in.
The technological premise of Jurassic Park is that scientists can reconstruct the genome of long-dead animals from preserved DNA fragments. It’s a compelling idea, if you think of DNA as a massively long and complex instruction set that tells a group of biological molecules how to build an animal. In principle, if we could reconstruct the genome of an extinct species, we would have the basic instruction set—the biological software—to reconstruct
individual members of it.
The bad news is that DNA-reconstruction-based de-extinction is far more complex than this. First you need intact fragments of DNA, which is not easy, as DNA degrades easily (and is pretty much impossible to obtain, as far as we know, for dinosaurs). Then you
need to be able to stitch all of your fragments together, which is akin to completing a billion-piece jigsaw puzzle without knowing what the final picture looks like. This is a Herculean task, although with breakthroughs in data manipulation and machine learning,
scientists are getting better at it. But even when you have your reconstructed genome, you need the biological “wetware”—all the stuff that’s needed to create, incubate, and nurture a new living thing, like eggs, nutrients, a safe space to grow and mature, and so on. Within all this complexity, it turns out that getting your DNA sequence right is just the beginning of translating that genetic code into a living, breathing entity. But in some cases, it might be possible.
In 2013, Sergey Zimov was introduced to the geneticist George Church at a conference on de-extinction. Church is an accomplished scientist in the field of DNA analysis and reconstruction, and a thought leader in the field of synthetic biology (which we’ll come
back to in chapter nine). It was a match made in resurrection biology heaven. Zimov wanted to populate his Pleistocene Park with mammoths, and Church thought he could see a way of
achieving this.
What resulted was an ambitious project to de-extinct the woolly mammoth. Church and others who are working on this have faced plenty of hurdles. But the technology has been advancing so fast that, as of 2017, scientists were predicting they would be able to reproduce the woolly mammoth within the next two years.
One of those hurdles was the lack of solid DNA sequences to work from. Frustratingly, although there are many instances of well preserved woolly mammoths, their DNA rarely survives being frozen for tens of thousands of years. To overcome this, Church and others
have taken a different tack: Take a modern, living relative of the mammoth, and engineer into it traits that would allow it to live on the Siberian tundra, just like its woolly ancestors.
Church’s team’s starting point has been the Asian elephant. This is their source of base DNA for their “woolly mammoth 2.0”—their starting source code, if you like. So far, they’ve identified fifty plus gene sequences they think they can play with to give their modern-day woolly mammoth the traits it would need to thrive in Pleistocene Park, including a coat of hair, smaller ears, and a constitution adapted to cold.
The next hurdle they face is how to translate the code embedded in their new woolly mammoth genome into a living, breathing animal. The most obvious route would be to impregnate a female Asian elephant with a fertilized egg containing the new code. But Asian elephants are endangered, and no one’s likely to allow such cutting edge experimentation on the precious few that are still around, so scientists are working on an artificial womb for their reinvented woolly mammoth. They’re making progress with mice and hope to crack the motherless mammoth challenge relatively soon.
It’s perhaps a stretch to call this creative approach to recreating a species (or “reanimation” as Church refers to it) “de-extinction,” as what is being formed is a new species. … (pp. 31-4)
This selection illustrates what Maynard does so very well throughout the book where he uses each film as a launching pad for a clear, readable description of relevant bits of science so you understand why the premise was likely, unlikely, or pure fantasy while linking it to contemporary practices, efforts, and issues. In the context of Jurassic Park, Maynard goes on to raise some fascinating questions such as: Should we revive animals rendered extinct (due to obsolescence or inability to adapt to new conditions) when we could develop new animals?
General thoughts
‘Films for the Future’ offers readable (to non-scientific types) science, lively writing, and the occasional ‘memorish’ anecdote. As well, Dr. Maynard raises the curtain on aspects of the scientific enterprise that most of us do not get to see. For example, the meeting between Sergey Zimov and George Church and how it led to new ‘de-extinction’ work’. He also describes the problems that the scientists encountered and are encountering. This is in direct contrast to how scientific work is usually presented in the news media as one glorious breakthrough after the next.
Maynard does discuss the issues of social inequality and power and ownership. For example, who owns your transplant or data? Puzzlingly, he doesn’t touch on the current environment where scientists in the US and elsewhere are encouraged/pressured to start up companies commercializing their work.
Nor is there any mention of how universities are participating in this grand business experiment often called ‘innovation’. (My March 15, 2017 posting describes an outcome for the CRISPR [gene editing system] patent fight taking place between Harvard University’s & MIT’s [Massachusetts Institute of Technology] Broad Institute vs the University of California at Berkeley and my Sept. 11, 2018 posting about an art/science exhibit in Vancouver [Canada] provides an update for round 2 of the Broad Institute vs. UC Berkeley patent fight [scroll down about 65% of the way.) *To read about how my ‘cultural blindness’ shows up here scroll down to the single asterisk at the end.*
There’s a foray through machine-learning and big data as applied to predictive policing in Maynard’s ‘Minority Report’ chapter (my November 23, 2017 posting describes Vancouver’s predictive policing initiative [no psychics involved], the first such in Canada). There’s no mention of surveillance technology, which if I recall properly was part of the future environment, both by the state and by corporations. (Mia Armstrong’s November 15, 2018 article for Slate on Chinese surveillance being exported to Venezuela provides interesting insight.)
The gaps are interesting and various. This of course points to a problem all science writers have when attempting an overview of science. (Carl Zimmer’s latest, ‘She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity’] a doorstopping 574 pages, also has some gaps despite his focus on heredity,)
Maynard has worked hard to give an comprehensive overview in a remarkably compact 279 pages while developing his theme about science and the human element. In other words, science is not monolithic; it’s created by human beings and subject to all the flaws and benefits that humanity’s efforts are always subject to—scientists are people too.
The readership for ‘Films from the Future’ spans from the mildly interested science reader to someone like me who’s been writing/blogging about these topics (more or less) for about 10 years. I learned a lot reading this book.
Next time, I’m hopeful there’ll be a next time, Maynard might want to describe the parameters he’s set for his book in more detail that is possible in his chapter headings. He could have mentioned that he’s not a cinéaste so his descriptions of the movies are very much focused on the story as conveyed through words. He doesn’t mention colour palates, camera angles, or, even, cultural lenses.
Take for example, his chapter on ‘Ghost in the Shell’. Focused on the Japanese animation film and not the live action Hollywood version he talks about human enhancement and cyborgs. The Japanese have a different take on robots, inanimate objects, and, I assume, cyborgs than is found in Canada or the US or Great Britain, for that matter (according to a colleague of mine, an Englishwoman who lived in Japan for ten or more years). There’s also the chapter on the Ealing comedy, The Man in The White Suit, an English film from the 1950’s. That too has a cultural (as well as, historical) flavour but since Maynard is from England, he may take that cultural flavour for granted. ‘Never let me go’ in Chapter Two was also a UK production, albeit far more recent than the Ealing comedy and it’s interesting to consider how a UK production about cloning might differ from a US or Chinese or … production on the topic. I am hearkening back to Maynard’s anecdote about movies giving him new ways of seeing and imagining the world.
There’s a corrective. A couple of sentences in Maynard’s introductory chapter cautioning that in depth exploration of ‘cultural lenses’ was not possible without expanding the book to an unreadable size followed by a sentence in each of the two chapters that there are cultural differences.
One area where I had a significant problem was with regard to being “programmed” and having “instinctual” behaviour,
As a species, we are embarrassingly programmed to see “different” as “threatening,” and to take instinctive action against it. It’s a trait that’s exploited in many science fiction novels and movies, including those in this book. If we want to see the rise of increasingly augmented individuals, we need to be prepared for some social strife. (p. 136)
These concepts are much debated in the social sciences and there are arguments for and against ‘instincts regarding strangers and their possible differences’. I gather Dr. Maynard hies to the ‘instinct to defend/attack’ school of thought.
One final quandary, there was no sex and I was expecting it in the Ex Machina chapter, especially now that sexbots are about to take over the world (I exaggerate). Certainly, if you’re talking about “social strife,” then sexbots would seem to be fruitful line of inquiry, especially when there’s talk of how they could benefit families (my August 29, 2018 posting). Again, there could have been a sentence explaining why Maynard focused almost exclusively in this chapter on the discussions about artificial intelligence and superintelligence.
Taken in the context of the book, these are trifling issues and shouldn’t stop you from reading Films from the Future. What Maynard has accomplished here is impressive and I hope it’s just the beginning.
Final note
Bravo Andrew! (Note: We’ve been ‘internet acquaintances/friends since the first year I started blogging. When I’m referring to him in his professional capacity, he’s Dr. Maynard and when it’s not strictly in his professional capacity, it’s Andrew. For this commentary/review I wanted to emphasize his professional status.)
*Nov. 23, 2018: I should have been more specific and said ‘academic scientists’. In Canada, the great percentage of scientists are academic. It’s to the point where the OECD (Organization for Economic Cooperation and Development) has noted that amongst industrialized countries, Canada has very few industrial scientists in comparison to the others.
The last time (June 18, 2018 post) I mentioned xenotransplantation (transplanting organs from one species into another species; see more here), it was in the context of an art/sci (or sciart) event coming to Vancouver (Canada).,
Patricia Piccinini’s Curious Imaginings Courtesy: Vancouver Biennale [downloaded from http://dailyhive.com/vancouver/vancouver-biennale-unsual-public-art-2018/]
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The latest edition of the Vancouver Biennale was featured in a June 6, 2018 news item on the Daily Hive (Vancouver),
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Melbourne artist Patricia Piccinini’s Curious Imaginings is expected to be one of the most talked about installations of the exhibit. Her style of “oddly captivating, somewhat grotesque, human-animal hybrid creature” is meant to be shocking and thought-provoking.
Piccinini’s interactive [emphasis mine] experience will “challenge us to explore the social impacts of emerging biotechnology and our ethical limits in an age where genetic engineering and digital technologies are already pushing the boundaries of humanity.”
Piccinini’s work will be displayed in the 105-year-old Patricia Hotel in Vancouver’s Strathcona neighbourhood. The 90-day ticketed exhibition [emphasis mine] is scheduled to open this September [2018].
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(The show opens on Sept. 14, 2018.)
At the time, I had yet to stumble across Ingfei Chen’s thoughtful dive into the topic in her May 9, 2018 article for Slate.com,
In the United States, the clock is ticking for more than 114,700 adults and children waiting for a donated kidney or other lifesaving organ, and each day, nearly 20 of them die. Researchers are devising a new way to grow human organs inside other animals, but the method raises potentially thorny ethical issues. Other conceivable futuristic techniques sound like dystopian science fiction. As we envision an era of regenerative medicine decades from now, how far is society willing to go to solve the organ shortage crisis?
I found myself pondering this question after a discussion about the promises of stem cell technologies veered from the intriguing into the bizarre. I was interviewing bioengineer Zev Gartner, co-director and research coordinator of the Center for Cellular Construction at the University of California, San Francisco, about so-called organoids, tiny clumps of organlike tissue that can self-assemble from human stem cells in a Petri dish. These tissue bits are lending new insights into how our organs form and diseases take root. Some researchers even hope they can nurture organoids into full-size human kidneys, pancreases, and other organs for transplantation.
Certain organoid experiments have recently set off alarm bells, but when I asked Gartner about it, his radar for moral concerns was focused elsewhere. For him, the “really, really thought-provoking” scenarios involve other emerging stem cell–based techniques for engineering replacement organs for people, he told me. “Like blastocyst complementation,” he said.
Never heard of it? Neither had I. Turns out it’s a powerful new genetic engineering trick that researchers hope to use for growing human organs inside pigs or sheep—organs that could be genetically personalized for transplant patients, in theory avoiding immune-system rejection problems. The science still has many years to go, but if it pans out, it could be one solution to the organ shortage crisis. However, the prospect of creating hybrid animals with human parts and killing them to harvest organs has already raised a slew of ethical questions. In 2015, the National Institutes of Health placed a moratorium on federal funding of this nascent research area while it evaluated and discussed the issues.
As Gartner sees it, the debate over blastocyst complementation research—work that he finds promising—is just one of many conversations that society needs to have about the ethical and social costs and benefits of future technologies for making lifesaving transplant organs. “There’s all these weird ways that we could go about doing this,” he said, with a spectrum of imaginable approaches that includes organoids, interspecies organ farming, and building organs from scratch using 3D bioprinters. But even if it turns out we can produce human organs in these novel ways, the bigger issue, in each technological instance, may be whether we should.
Gartner crystallized things with a downright creepy example: “We know that the best bioreactor for tissues and organs for humans are human beings,” he said. Hypothetically, “the best way to get you a new heart would be to clone you, grow up a copy of yourself, and take the heart out.” [emphasis mine] Scientists could probably produce a cloned person with the technologies we already have, if money and ethics were of no concern. “But we don’t want to go there, right?” he added in the next breath. “The ethics involved in doing it are not compatible with who we want to be as a society.”
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This sounds like Gartner may have been reading some science fiction, specifically, Lois McMaster Bujold and her Barrayar series where she often explored the ethics and possibilities of bioengineering. At this point, some of her work seems eerily prescient.
As for Chen’s article, I strongly encourage you to read it in its entirety if you have the time.
Medicine, healing, and big money
At about the same time, there was a May 31, 2018 news item on phys.org offering a perspective from some of the leaders in the science and the business (Note: Links have been removed),
Over the past few years, researchers led by George Church have made important strides toward engineering the genomes of pigs to make their cells compatible with the human body. So many think that it’s possible that, with the help of CRISPR technology, a healthy heart for a patient in desperate need might one day come from a pig.
“It’s relatively feasible to change one gene in a pig, but to change many dozens—which is quite clear is the minimum here—benefits from CRISPR,” an acronym for clustered regularly interspaced short palindromic repeats, said Church, the Robert Winthrop Professor of Genetics at Harvard Medical School (HMS) and a core faculty member of Harvard’s Wyss Institute for Biologically Inspired Engineering. Xenotransplantation is “one of few” big challenges (along with gene drives and de-extinction, he said) “that really requires the ‘oomph’ of CRISPR.”
To facilitate the development of safe and effective cells, tissues, and organs for future medical transplantation into human patients, Harvard’s Office of Technology Development has granted a technology license to the Cambridge biotech startup eGenesis.
Co-founded by Church and former HMS doctoral student Luhan Yang in 2015, eGenesis announced last year that it had raised $38 million to advance its research and development work. At least eight former members of the Church lab—interns, doctoral students, postdocs, and visiting researchers—have continued their scientific careers as employees there.
“The Church Lab is well known for its relentless pursuit of scientific achievements so ambitious they seem improbable—and, indeed, [for] its track record of success,” said Isaac Kohlberg, Harvard’s chief technology development officer and senior associate provost. “George deserves recognition too for his ability to inspire passion and cultivate a strong entrepreneurial drive among his talented research team.”
The license from Harvard OTD covers a powerful set of genome-engineering technologies developed at HMS and the Wyss Institute, including access to foundational intellectual property relating to the Church Lab’s 2012 breakthrough use of CRISPR, led by Yang and Prashant Mali, to edit the genome of human cells. Subsequent innovations that enabled efficient and accurate editing of numerous genes simultaneously are also included. The license is exclusive to eGenesis but limited to the field of xenotransplantation.
A May 30, 2018 Harvard University news release by Caroline Petty, which originated the news item, explores some of the issues associated with incubating humans organs in other species,
The prospect of using living, nonhuman organs, and concerns over the infectiousness of pathogens either present in the tissues or possibly formed in combination with human genetic material, have prompted the Food and Drug Administration to issue detailed guidance on xenotransplantation research and development since the mid-1990s. In pigs, a primary concern has been that porcine endogenous retroviruses (PERVs), strands of potentially pathogenic DNA in the animals’ genomes, might infect human patients and eventually cause disease. [emphases mine]
That’s where the Church lab’s CRISPR expertise has enabled significant advances. In 2015, the lab published important results in the journal Science, successfully demonstrating the use of genome engineering to eliminate all 62 PERVs in porcine cells. Science later called it “the most widespread CRISPR editing feat to date.”
In 2017, with collaborators at Harvard, other universities, and eGenesis, Church and Yang went further. Publishing again in Science, they first confirmed earlier researchers’ fears: Porcine cells can, in fact, transmit PERVs into human cells, and those human cells can pass them on to other, unexposed human cells. (It is still unknown under what circumstances those PERVs might cause disease.) In the same paper, they corrected the problem, announcing the embryogenesis and birth of 37 PERV-free pigs. [Note: My July 17, 2018 post features research which suggests CRISPR-Cas9 gene editing may cause greater genetic damage than had been thought.]
“Taken together, those innovations were stunning,” said Vivian Berlin, director of business development in OTD, who manages the commercialization strategy for much of Harvard’s intellectual property in the life sciences. “That was the foundation they needed, to convince both the scientific community and the investment community that xenotransplantation might become a reality.”
“After hundreds of tests, this was a critical milestone for eGenesis — and the entire field — and represented a key step toward safe organ transplantation from pigs,” said Julie Sunderland, interim CEO of eGenesis. “Building on this study, we hope to continue to advance the science and potential of making xenotransplantation a safe and routine medical procedure.”
Genetic engineering may undercut human diseases, but also could help restore extinct species, researcher says. [Shades of the Jurassic Park movies!]
It’s not, however, the end of the story: An immunological challenge remains, which eGenesis will need to address. The potential for a patient’s body to outright reject transplanted tissue has stymied many previous attempts at xenotransplantation. Church said numerous genetic changes must be achieved to make porcine organs fully compatible with human patients. Among these are edits to several immune functions, coagulation functions, complements, and sugars, as well as the PERVs.
“Trying the straight transplant failed almost immediately, within hours, because there’s a huge mismatch in the carbohydrates on the surface of the cells, in particular alpha-1-3-galactose, and so that was a showstopper,” Church explained. “When you delete that gene, which you can do with conventional methods, you still get pretty fast rejection, because there are a lot of other aspects that are incompatible. You have to take care of each of them, and not all of them are just about removing things — some of them you have to humanize. There’s a great deal of subtlety involved so that you get normal pig embryogenesis but not rejection.
“Putting it all together into one package is challenging,” he concluded.
In short, it’s the next big challenge for CRISPR.
Not unexpectedly, there is no mention of the CRISPR patent fight between Harvard/MIT’s (Massachusetts Institute of Technology) Broad Institute and the University of California at Berkeley (UC Berkeley). My March 15, 2017 posting featured an outcome where the Broad Institute won the first round of the fight. As I recall, it was a decision based on the principles associated with King Solomon, i.e., the US Patent Office, divided the baby and UCBerkeley got the less important part of the baby. As you might expect the decision has been appealed. In an April 30, 2018 piece, Scientific American reprinted an article about the latest round in the fight written by Sharon Begley for STAT (Note: Links have been removed),
All You Need to Know for Round 2 of the CRISPR Patent Fight
It’s baaaaack, that reputation-shredding, stock-moving fight to the death over key CRISPR patents. On Monday morning in Washington, D.C., the U.S. Court of Appeals for the Federal Circuit will hear oral arguments in University of California v. Broad Institute. Questions?
How did we get here? The patent office ruled in February 2017 that the Broad’s 2014 CRISPR patent on using CRISPR-Cas9 to edit genomes, based on discoveries by Feng Zhang, did not “interfere” with a patent application by UC based on the work of UC Berkeley’s Jennifer Doudna. In plain English, that meant the Broad’s patent, on using CRISPR-Cas9 to edit genomes in eukaryotic cells (all animals and plants, but not bacteria), was different from UC’s, which described Doudna’s experiments using CRISPR-Cas9 to edit DNA in a test tube—and it was therefore valid. The Patent Trial and Appeal Board concluded that when Zhang got CRISPR-Cas9 to work in human and mouse cells in 2012, it was not an obvious extension of Doudna’s earlier research, and that he had no “reasonable expectation of success.” UC appealed, and here we are.
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For anyone who may not realize what the stakes are for these institutions, Linda Williams in a March 16, 1999 article for the LA Times had this to say about universities, patents, and money,
The University of Florida made about $2 million last year in royalties on a patent for Gatorade Thirst Quencher, a sports drink that generates some $500 million to $600 million a year in revenue for Quaker Oats Co.
The payments place the university among the top five in the nation in income from patent royalties.
Oh, but if some people on the Gainesville, Fla., campus could just turn back the clock. “If we had done Gatorade right, we would be getting $5 or $6 million (a year),” laments Donald Price, director of the university’s office of corporate programs. “It is a classic example of how not to handle a patent idea,” he added.
Gatorade was developed in 1965 when many universities were ill equipped to judge the commercial potential of ideas emerging from their research labs. Officials blew the university’s chance to control the Gatorade royalties when they declined to develop a professor’s idea.
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The Gatorade story does not stop there and, even though it’s almost 20 years old, this article stands the test of time. I strongly encourage you to read it if the business end of patents and academia interest you or if you would like to develop more insight into the Broad Institute/UC Berkeley situation.
Getting back to the science, there is that pesky matter of diseases crossing over from one species to another. While, Harvard and eGenesis claim a victory in this area, it seems more work needs to be done.
A shortage of organs for transplantation — including kidneys and hearts — means that many patients die while still on waiting lists. So, research at the University of Alabama at Birmingham and other sites has turned to pig organs as an alternative. [emphasis mine]
Using gene-editing, researchers have modified such organs to prevent rejection, and research with primates shows the modified pig organs are well-tolerated.
An added step is needed to ensure the safety of these inter-species transplants — sensitive, quantitative assays for viruses and other infectious microorganisms in donor pigs that potentially could gain access to humans during transplantation.
The U.S. Food and Drug Administration requires such testing, prior to implantation, of tissues used for xenotransplantation from animals to humans. It is possible — though very unlikely — that an infectious agent in transplanted tissues could become an emerging infectious disease in humans.
In a paper published in Xenotransplantation, Mark Prichard, Ph.D., and colleagues at UAB have described the development and testing of 30 quantitative assays for pig infectious agents. These assays had sensitivities similar to clinical lab assays for viral loads in human patients. After validation, the UAB team also used the assays on nine sows and 22 piglets delivered from the sows through caesarian section.
“Going forward, ensuring the safety of these organs is of paramount importance,” Prichard said. “The use of highly sensitive techniques to detect potential pathogens will help to minimize adverse events in xenotransplantation.”
“The assays hold promise as part of the screening program to identify suitable donor animals, validate and release transplantable organs for research purposes, and monitor transplant recipients,” said Prichard, a professor in the UAB Department of Pediatrics and director of the Department of Pediatrics Molecular Diagnostics Laboratory.
The UAB researchers developed quantitative polymerase chain reaction, or qPCR, assays for 28 viruses sometimes found in pigs and two groups of mycoplasmas. They established reproducibility, sensitivity, specificity and lower limit of detection for each assay. All but three showed features of good quantitative assays, and the lower limit of detection values ranged between one and 16 copies of the viral or bacterial genetic material.
Also, the pig virus assays did not give false positives for some closely related human viruses.
As a start to understanding the infectious disease load in normal healthy animals and ensuring the safety of pig tissues used in xenotransplantation research, the researchers then screened blood, nasal swab and stool specimens from nine adult sows and 22 of their piglets delivered by caesarian section.
Mycoplasma species and two distinct herpesviruses were the most commonly detected microorganisms. Yet 14 piglets that were delivered from three sows infected with either or both herpesviruses were not infected with the herpesviruses, showing that transmission of these viruses from sow to the caesarian-delivery piglet was inefficient.
Prichard says the assays promise to enhance the safety of pig tissues for xenotransplantation, and they will also aid evaluation of human specimens after xenotransplantation.
The UAB researchers say they subsequently have evaluated more than 300 additional specimens, and that resulted in the detection of most of the targets. “The detection of these targets in pig specimens provides reassurance that the analytical methods are functioning as designed,” said Prichard, “and there is no a priori reason some targets might be more difficult to detect than others with the methods described here.”
As is my custom, here’s a link to and a citation for the paper,
Xenotransplantation panel for the detection of infectious agents in pigs by Caroll B. Hartline, Ra’Shun L. Conner, Scott H. James, Jennifer Potter, Edward Gray, Jose Estrada, Mathew Tector, A. Joseph Tector, Mark N. Prichard. Xenotransplantaion Volume 25, Issue 4 July/August 2018 e12427 DOI: https://doi.org/10.1111/xen.12427 First published: 18 August 2018
This paper is open access.
All this leads to questions about chimeras. If a pig is incubating organs with human cells it’s a chimera but then means the human receiving the organ becomes a chimera too. (For an example, see my Dec. 22, 2013 posting where there’s mention of a woman who received a trachea from a pig. Scroll down about 30% of the way.)
What is it to be human?
A question much beloved of philosophers and others, the question seems particularly timely with xenotransplantion and other developments such neuroprosthetics (cyborgs) and neuromorphic computing (brainlike computing).
As I’ve noted before, although not recently, popular culture offers a discourse on these issues. Take a look at the superhero movies and the way in which enhanced humans and aliens are presented. For example, X-Men comics and movies present mutants (humans with enhanced abilities) as despised and rejected. Video games (not really my thing but there is the Deus Ex series which has as its hero, a cyborg also offer insight into these issues.
Other than popular culture and in the ‘bleeding edge’ arts community, I can’t recall any public discussion on these matters arising from the extraordinary set of technologies which are being deployed or prepared for deployment in the foreseeable future.
(If you’re in Vancouver (Canada) from September 14 – December 15, 2018, you may want to check out Piccinini’s work. Also, there’s ” NCSU [North Carolina State University] Libraries, NC State’s Genetic Engineering and Society (GES) Center, and the Gregg Museum of Art & Design have issued a public call for art for the upcoming exhibition Art’s Work in the Age of Biotechnology: Shaping our Genetic Futures.” from my Sept. 6, 2018 posting. Deadline: Oct. 1, 2018.)
At a guess, there will be pushback from people who have no interest in debating what it is to be human as they already know, and will find these developments, when they learn about them, to be horrifying and unnatural.
It was the tech community which brought Hedy Lamarr’s scientific and technical accomplishments to light in the 1990s. The movie actress was better known for other aspects of her work and life.
She was the first actress to portray an orgasm on screen, the movie was Ecstasy (in English), the year was 1933; and, Hedy Lamarr was 18 years-old. Shortly after the film was released, Lamarr, of Jewish descent, married Friedrich Mandl, a wealthy Austrian with ties to fascist regimes led by Adolph Hitler and Benito Mussolini. A controlling and jealous man, she eventually escaped Mandl in the middle of the night with all the jewels she could pack on her person.
That’s just the prelude for a documentary celebrating the extraordinary Lamarr. ‘Bombshell: The Hedy Lamarr Story’ (directed and written by Alexandra Dean) has been making its way around the festival circuit for the last several months. I saw it at the Vancouver International Film Festival (VIFF) in October 2017 and the house was packed.
(If you missed it on the festival circuit, don’t worry. It’s being broadcast by most, if not all PBS stations, on May 18, 2018 as part of the American Masters series.)
*ETA video clips May 18, 2018 at 0945 hours PDT*
Over the last few decades there’s been a major reevaluation of Lamarr’s place in history. She was dangerous not just for her beauty (bombshell) but also in the way that people who aren’t easily categorized are always dangerous.
Before she did her ground-breaking work as an inventor and after her dramatic middle-of-the-night escape, Lamarr made her way to London* where she sought out Louis B. Mayer in 1937 and turned down his offer of a contract at MGM. Not enough money. Instead, she booked passage n a ship bound for New York City which was also carrying Louis B. Mayer and his wife. By the time they landed, Lamarr had gotten a contract that she was happy with and a brand-new name. Hedwig Eva Maria Kiesler effectively became Hedy Lamarr for the rest of her life.
Lamarr’s famous quote: “Any girl can be glamorous. All you have to do is stand still and look stupid,” provides an interesting juxtaposition with her role (along with avant-garde musician and composer George Antheil) in developing a technology that laid the basis for secure Wi-Fi, GPS (global positioning system), and Bluetooth. Or as some of us think of it, life in the 21st century.
She claimed to have advised Howard Hughes on the design for the of his airplanes; she was inspired by the wings on birds and fins on fish. She created a tablet that when reconstituted with water became a carbonated drink (according to Lamarr, it was not very tasty). There was also her influence in the field of plastic surgery. Those incisions that are in hard-to-see places? That was at Hedy Lamarr’s suggestion.
Her inventions spanned electrical engineering (telecommunications), bio-inspired engineering and physics (airplane wings), chemistry (the drink tablets), and plastic surgery. That’s an extraordinary range and there’s more. She created her own movie production company in 1945/46* (it was a failure) and was instrumental in designing a resort (she was never fairly recompensed for that).
She suffered throughout her life in various ways.The US government shafted her and George Antheil by politely refusing their invention in 1942. To be fair, it would have been difficult to use with the technology available at the time but somebody must have recognized its potential. At some point in the 1950s the US Navy developed the technology (without informing either inventor or compensating them as had been their deal).
There was more, her achievements were ignored or, worse, attributed to anyone except her the better part of her life; the Hollywood factory is not kind to older actresses, especially those of Lamarr’s generation; and she made serious mistakes.
Ironically, one of those mistakes involved plastic surgery. It’s hard to know what the effect will be on television but in the movie house, there was a big gasp when some footage from her last years was shown. She’s not monstrous but after an hour or more of footage from her ‘glamorous’ years, it’s a bit of a shock. If you can see past the effects of some ‘bad’ plastic surgery, you’ll find a woman who despite everything kept on. She never gave up and there’s a kind of beauty in that act which is indelible in a way that her physical beauty could never hope to be.
The documentary is fascinating not only for what it includes but for what it doesn’t. You’d think she’d never had a woman friend in her life but according to J. E. Smyth’s 2018 book ‘Nobody’s Girl Friday; The Women Who Ran Hollywood’, she and Bette Davis were good friends. There’s also mention of her poverty but none of her late life litigiousness and the $3M estate she left when she died in 2000.*** At a guess, having learned from the debacle with the US Navy (she could have sued but didn’t realize she had the right), she litigated her way into some financial health. As for the ‘Time’s Up’ and ‘Me Too’ movements which have formed since the Hollywood sex scandals of 2017 – ????, one can only imagine what Lamarr’s stories might have been.
If you have the time, see the documentary. Lamarr was a helluva dame.
*’Paris’ corrected to ‘London’ and ‘1945’ changed to 1945/46′ on on May 21, 2018 after watching the PBS broadcast of the documentary on May 18, 2018.
.***ETA May 21, 2018: See the Hedy Lamarr Wikipedia entry for more about her estate and other details of her life.***
It’s not often you see research that combines biologically inspired engineering and a molecular biophysicist with a professional animator who worked at Peter Jackson’s (Lord of the Rings film trilogy, etc.) Park Road Post film studio. An Oct. 18, 2017 news item on ScienceDaily describes the project,
Like many other scientists, Don Ingber, M.D., Ph.D., the Founding Director of the Wyss Institute, is concerned that non-scientists have become skeptical and even fearful of his field at a time when technology can offer solutions to many of the world’s greatest problems. “I feel that there’s a huge disconnect between science and the public because it’s depicted as rote memorization in schools, when by definition, if you can memorize it, it’s not science,” says Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, and Professor of Bioengineering at the Harvard Paulson School of Engineering and Applied Sciences (SEAS). “Science is the pursuit of the unknown. We have a responsibility to reach out to the public and convey that excitement of exploration and discovery, and fortunately, the film industry is already great at doing that.”
To see if entertainment could offer a solution to this challenge, Ingber teamed up with Charles Reilly, Ph.D., a molecular biophysicist, professional animator, and Staff Scientist at the Wyss Institute who previously worked at movie director Peter Jackson’s Park Road Post film studio, to create a film that would capture viewers’ imaginations by telling the story of a biological process that was accurate down to the atomic level. “Don and I quickly found that we have a lot of things in common, especially that we’re both systems thinkers,” says Reilly. “Applying an artistic process to science frees you from the typically reductionist approach of analyzing one particular hypothesis and teaches you a different way of observing things. As a result, we not only created an entertaining tool for public outreach, we conducted robust theoretical biology research that led to new scientific insight into molecular-scale processes.” The research is now published in ACS Nano and the film can be found here.
Wyss researchers created a model of an axoneme that displays how different segments of the microtubules bend and flex relative to each other to create movement. Credit: Wyss Institute at Harvard University
Any good movie needs characters and drama, and a “hook” to get the audience invested in watching. The scientists decided to make a parody of a trailer for a Star Wars® movie, but instead of showing starship cruisers hurtling through space towards the Death Star, they chose a biological process with its own built-in narrative: the fertilization of an egg by a sperm, in which millions of sperm race to be the one that succeeds and creates the next generation of life. The patterns and mechanics of sperm swimming have been studied and described in scientific literature, but visually showing the accurate movement of a sperm tail required tackling one of the toughest challenges facing science today: how to create a multi-scale biological model that maintains accuracy at different sizes, from cells all the way down to atoms. That would be like starting with the Empire State Building and then zooming in close enough to see every individual screw, nut and bolt that holds it together, as well as how individual water molecules flow inside its pipes, while maintaining crystal-clear resolution – not an easy task.
“It turns out that creating an accurate biological model and creating a believable computer-generated depiction of life in film are very similar, in that you’re constantly troubleshooting and modifying your virtual object until it fits the way things actually look and move,” says Reilly. “However, for biology, the simulations also have to align with recorded scientific data and theoretical models that have previously been experimentally validated.” The scientists created a design-based animation pipeline that integrates physics-based film animation software with molecular dynamics simulation software to create a model of how a sperm tail moves based on scientific data, with the criterion that the model had to work across all size scales. “This is really a design thinking approach, where you have to be willing to throw out your model if it doesn’t work correctly when you integrate it with data from another scale,” Reilly says. “A lot of scientific investigations use a reductionist approach, focusing on one molecule or one biological system with higher and higher resolution without placing it in context, which makes it difficult to converge on a picture of the larger whole.”
This video shows dynein’s two different shapes as determined from scientific observations, and how the Wyss researchers’ molecular model of dynein’s movement fits those conformations. Credit: Wyss Institute at Harvard University
The core of a sperm’s whip-like tail is the axoneme, a long tube consisting of nine pairs of microtubules arranged in a column around a central pair, all of which extend the entire length of the tail. The axoneme’s rhythmic bending and stretching is the source of the tail’s movement, and the scientists knew they needed to realistically depict that process in order to show the film’s viewers how a sperm moves. Rather than construct a model in a linear fashion by “zooming in” or “zooming out” to add more information to a single starting structure, they built the model at different scales simultaneously, repeatedly checking it against scientific data to ensure it was accurate and modifying it until the pieces fit together.
The axoneme’s movement is accomplished via rows of motor proteins called dyneins that are attached along the microtubules and exert force on them so the microtubules “slide” past each other, which then causes the entire axoneme and sperm tail to bend and move. The dynein protein has a long “arm” portion that grabs onto the neighboring microtubule and, when the protein changes from one shape to another, pulls the microtubule along with it. Dynein switches between these different conformations as a result of the conversion of a molecule of ATP to ADP at a specific binding site on the protein, which releases energy as a chemical bond is broken. To model this molecular motor, the scientists created a molecular dynamics simulation of a dynein protein and applied energy at the ATP binding site to approximate the transfer of energy from ATP. They found that this caused atoms in the entire protein to move in random directions when they performed their simulation of dynein floating in solution, as most conventional scientific simulations do. However, when they then “fixed” a specific hinge region of the dynein molecule that is known to connect dynein to its microtubule, they discovered that the dynein spontaneously moved in its characteristic direction when force was applied at the ATP binding site, matching the way it moves in nature.
This video shows rows of dynein proteins along the microtubules of an axoneme moving in sync to cause the axoneme’s motion, like rowers pulling synchronously in a boat. Credit: Wyss Institute at Harvard University
“Not only is our physics-based simulation and animation system as good as other data-based modeling systems, it led to the new scientific insight that the limited motion of the dynein hinge focuses the energy released by ATP hydrolysis, which causes dynein’s shape change and drives microtubule sliding and axoneme motion,” says Ingber. “Additionally, while previous studies of dynein have revealed the molecule’s two different static conformations, our animation visually depicts one plausible way that the protein can transition between those shapes at atomic resolution, which is something that other simulations can’t do. The animation approach also allows us to visualize how rows of dyneins work in unison, like rowers pulling together in a boat, which is difficult using conventional scientific simulation approaches.”
Using this biologically accurate model of how dynein moves the microtubules within the axoneme, Ingber and Reilly created a short film called “The Beginning,” which draws parallels between sperm swimming toward an egg and spaceships flying toward a planet in space, giving an artistic bent to a scientific topic. The film depicts several sperm attempting to fertilize the egg, “zooms in” on one sperm’s tail to show how the dynein proteins move in sync to cause the tail to bend and flex, and ends with the sperm’s successful journey into the egg and the initiation of cell division that will ultimately create a new organism. The scientists submitted the film along with the paper to several academic journals, and it took a long time before they found an open-minded editor who recognized that the paper and film together were a powerful demonstration of how starting with an artistic goal can end up generating new scientific discoveries along with a tool for public outreach.
*Due to distortion images deleted March 9, 2018.*
“Both science and art are about observation, interpretation, and communication. Our goal is that presenting science to the public in an entertaining, system-based way, rather than bogging them down with a series of scattered facts, will help more people understand it and feel that they can contribute to the scientific conversation. The more people engage with science, the more likely humanity is to solve the world’s big problems,” says Reilly. “I also hope that this paper and video encourage more scientists to take an artistic approach when they start a new project, not necessarily to create a narrative-based story, but to explore their idea the way an artist explores a canvas, because that makes the mind open to a different form of serendipity that can lead to unexpected results.”
“The Wyss Institute is driven by biological design. In this project, we used design tools and approaches borrowed from the art world to solve problems related to motion, form, and complexity to create something entertaining, which ultimately led to new scientific insights and, hopefully, new ways to excite the public about science,” says Ingber. “We’ve demonstrated that art and science can benefit each other in a truly reciprocal way, and we hope that this project spurs future collaborations with the entertainment industry so that both art and science can get even closer to depicting reality in ways that anyone can appreciate and enjoy.”
*Due to distortion images deleted on March 9, 2018.*
Part 1 featured my commentary on both Calestous Juma’s 2016 book, ”Innovation and Its Enemies; Why People Resist New Technologies” and Meanie Keene’s 2015 book, “Science in Wonderland; The scientific fairy tales of Victorian Britain.” Now for an emerging technology; genetically modified fish (AquAdvantage salmon) and my final comments on the books and the contrasting ways the adoption of new technologies and science is presented.
Fish
AquAdvanage salmon features as one of Calestous Juma’s contemporary emerging technologies. I mentioned the fish here in a May 20, 2016 posting when the fish was approved for consumption in Canada; this followed an earlier mention in a Dec. 4, 2015 posting when the US Food and Drug Administration (FDA) approved the salmon for consumption in the US (from the 2015 posting),
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For the final excerpt from the December 2015 issue, there’s this about genetically engineered salmon,
Genetically Modified Salmon: Coming to a River Near You?
After nearly 20 years of effort, the Food and Drug Administration has approved genetically engineered salmon produced by AquaBounty Technologies, as fit for consumption and will not have to be labeled as genetically engineered. This salmon is capable of growing twice as fast as a non-engineered farmed salmon in as little as half of the time, however, it’s still likely to be at least two years before these salmon reach supermarkets. Some groups are concerned about the environmental implications should these salmon accidentally get released, or escape, into the wild, even though AquaBounty says its salmon will be all female and sterile.
AquaBounty’s salmon (background) has been genetically modified to grow bigger and faster than a conventional Atlantic salmon of the same age (foreground.) Courtesy of AquaBounty Technologies, Inc. [downloaded from http://www.npr.org/sections/thesalt/2015/06/24/413755699/genetically-modified-salmon-coming-to-a-river-near-you]
The link from the newsletter points to a June 24, 2015 article by Jessie Rack for US National Public Radio’s Salt on the Table program (Note: Links have been removed),
One concern repeatedly raised by critics who don’t want the FDA to give the transgenic fish the green light: What would happen if these fish got out of the land-based facilities where they’re grown and escaped into the wild? Would genetically modified salmon push out their wild counterparts or permanently alter habitat? In a review paper published this month in the journal BioScience, scientists tackle that very question.
Robert H. Devlin, a scientist at Fisheries and Oceans Canada, led a team that reviewed more than 80 studies analyzing growth, behavior and other trait differences between genetically modified and unaltered fish. The scientists used this to predict what might happen if fish with modified traits were unleashed in nature.
Genetically modified salmon contain the growth hormone gene from one fish, combined with the promoter of an antifreeze gene from another. This combination both increases and speeds up growth, so the salmon grow faster.
Altering a fish’s genes also changes other traits, the review found. Genetically modified salmon eat more food, spend more time near the surface of the water, and don’t tend to associate in groups. They develop at a dramatically faster rate, and their immune function is reduced.
But would these altered traits help genetically modified salmon outcompete wild salmon, while at the same time making them less likely to thrive in nature? It’s unclear, says Fredrik Sundström, one of the study authors and an ecologist at Uppsala University in Sweden.
You may note the lead researcher for the literature review, a Canadian scientist was not quoted. This is likely due to the muzzle the Conservative government (still in power in June 2015 ) had applied to government scientists.
One last thing about AquAdvantage salmon, there is a very good Dec. 3, 2015 posting by Meredith Hamel focusing on their Canadian connections on her BiologyBizarre blog/magazine (Note: A link has been removed),
“For the first time anywhere in the world, a genetically engineered animal has been approved for human consumption” announced Peter Mansbridge on CBC [Canadian Broadcasting Corporation] news on November 20 [2015]. Members of society do not agree on how genetically modified fruits and vegetables should be labelled, if at all, but we are already moving on to genetically modified animals for human consumption. The AquAdvantage salmon by the US company AquaBounty can grow quicker and go to market twice as fast as regular farmed salmon using less feed. This genetically engineered salmon, whose fertilized eggs are produced at an inland facility in P.E.I [Prince Edward Island], Canada [emphasis mine] and raised at a facility in Panama, has been approved by the FDA after a long 20 year wait. AquAdvantage salmon could be the first genetically engineered meat we eat but opposition to approving it in Canada shows this salmon is not yet finished swimming against the current.
She goes on to describe in detail how these salmon are created (not excerpted here) and pinpoints another Canadian connection and political ramifications (Note: Links have been removed),
Head of Ocean Sciences Department at Memorial University [province of Newfoundland and Labrador], Garth Fletcher told The Star he was happy to see his creation get approved as he didn’t think approval would happen in his lifetime. Fletcher is no longer involved with AquaBounty but began working on this growth improved transgenic fish with other scientists back in 1982. On CBC news he said “the risk is as minimal as you could ever expect to get with any product.”
While the salmon is not approved in Canada for human consumption, some grocery store chains have already boycotted AquAdvantage salmon. The first step, the production of eggs in P.E.I has been approved by the federal government. Now there is a court battle with British Columbia’s Living Oceans Society and Nova Scotia’s Ecology Action Centre together challenging the federal government’s approval. They are concerned AquAdvantage salmon would be toxic to the environment as an invasive species if they were to escape and that this was not adequately assessed. Secondly they argue that Environment Canada had a duty to inform the public but failed to do so.
Natalie Huneault at Environment Canada told the National Oberver, “there were no concerns identified to the environment or to the indirect health of Canadians due to the contained production of these GM fish eggs for export.”
Anastasia Bodnar over on Biology Fortified does an excellent job of going through the risks and mitigation of AquAdvantage salmon (here and here) both with respect to safety of eating this meat product as well as in preventing escapee transgenic fish from contaminating wild salmon populations. The Fisheries and Oceans Canada document containing assessment of risks to the environment and health are found here. Due to the containment facility and procedures there is extremely low likelihood that any fertile genetically modified salmon would escape to an area where it could survive and reproduce.
The failure of Environment Canada to properly inform and have a discussion with the public before approving the P.E.I fertilized egg production facility will certainly have increased public mistrust and fear of this genetically engineered salmon. I think that if the public feel that this step has already taken place behind their back, future discussion about approving genetically engineered salmon as safe to eat, is only going to be met with suspicion.
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Since the 2016 approval, AquAdvantage salmon, 4.5M tonnes has been sold in Canada according to an Aug. 8, 2017 article by Sima Shakeri for Huffington Post (Note: Links have been removed),
After decades of trying to get approval by in North America, genetically modified Atlantic salmon has been sold to consumers in Canada.
AquaBounty Technologies, an American company that produces the Atlantic salmon, confirmed it had sold 4.5 tonnes of the modified fish on August 4 [2017], the Scientific American reported.
The fish have been engineered with a growth hormone gene from Chinook salmon to grow faster than regular salmon and require less food. They take about 18 months to reach market size, which is much quicker than the 30 months or so for conventional salmon.
The Washington Post wrote AquaBounty’s salmon also contains a gene from the ocean pout that makes the salmon produce the growth hormone gene all-year-round.
The company produces the eggs in a facility in P.E.I., which is currently being expanded, and then they’re shipped to Panama where the fish are raised.
Health Canada assessed the AquAdvantage salmon and concluded it “did not pose a greater risk to human health than salmon currently available on the Canadian market,” and that it would have no impact on allergies nor a difference in nutritional value compared to other farmed salmon.
Because of that, the AquAdvantage product is not required to be specially labelled as genetically modified, and is up to the discretion of retailers.
Scientific American has reproduced a piece by Emily Waltz (originally published August 4, 2017, the date Canadian consumers discovered the fish was being sold, in Nature). From the Aug. 7, 2017 Scientific American republication (Note: A link has been removed),
AquaBounty’s gruelling path from scientific discovery to market terrified others working in animal biotechnology, and almost put the company out of business on several occasions. Scientists first demonstrated the fast-growing fish in 1989. They gave it a growth-hormone gene from Chinook salmon (Oncorhynchus tshawytscha), along with genetic regulatory elements from a third species, the ocean pout (Zoarces americanus). The genetic modifications enable the salmon to produce a continuous low level of growth hormone.
AquaBounty formed around the technology in the early 1990s and approached regulators in the United States soon after. It then spent almost 25 years in regulatory limbo. The US Food and Drug Administration (FDA) approved the salmon for consumption in November 2015, and Canadian authorities came to the same decision six months later. Neither country requires the salmon to be labelled as genetically engineered.
But unlike in Canada, political battles in the United States have stalled the salmon’s entry into the marketplace. …
Activists in both the United States and Canada have demanded that regulators reconsider their decisions, and some have filed lawsuits. …
Waltz includes this quote from an interested party,
The sale of the fish follows a long, hard-fought battle to navigate regulatory systems and win consumer acceptance. “Somebody’s got to be first and I’m glad it was them and not me,” says James West, a geneticist at Vanderbilt University in Nashville, Tennessee, who co-founded AgGenetics, a start-up company in Nashville that is engineering cattle for the dairy and beef industries. “If they had failed, it might have killed the engineered livestock industry for a generation,” he says.
Canadians don’t necessarily respond in the same way that Americans do. The stem cell controversies to the south of us never reached the same fury and pitch although there were some significant impacts felt by the research community. Similarly the GMO (genetically modified organisms) controversies were felt here but in nowhere near the same degree as Europe. That doesn’t mean there won’t be problems this time but trying to determine how Canadians are likely to respond can be tricky especially when most of us don’t know much about GMO foods as Meham Abedi notes in her August 9, 2017 article for Global TV news (Note: Link have been removed),
On Wednesday [Aug. 9, 2017], an Angus Reid survey revealed that most Canadians admit they don’t know much about genetically modified organisms, but still want more transparency.
Of the 1,512 respondents, 24 per cent said they had “never heard of them” or only heard the term, 60 per cent said they “know a little bit about” GMO food, while only 16 per cent were “very familiar” with what it entails.
However, 83 per cent of Canadians surveyed said at least some GMO food labelling should [be] mandatory in grocery stores.
The report echos 2016 Health Canada findings that Canadians’ opinions on the products were defined by “confusion, misinformation, and generally low awareness/understanding.”
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The Angus Reid survey was conducted between June 8-13, 2017 [emphasis mine], by 1,512 Canadian adults. It is considered accurate +/- 2.5 percentage points, 19 times out of 20.
It’s hard to know how “confusion, misinformation, and generally low awareness/understanding,” is going to play out but it doesn’t seem a good idea to just sneak GMO salmon into the Canadian marketplace. Notably, Juma argues for more public education in his book and while it might not smooth the path as much as he and other innovation enthusiasts might prefer, it certainly couldn’t hurt.
It might also be useful to consider the idea that not all resistance is bad and to be avoided. Tess Doezema in her April 26, 2017 article (Skepticism About Biotechnology Isn’t Anti-Science) presents a persuasive argument suggesting that public concerns don’t deserve to be dismissed (Note: Links have been removed),
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To many in bioscience and biotechnology circles, this [AquAdvantage salmon] is a case of politics contaminating science. In an open letter to President Obama in 2014, a group of “concerned international scientists and global technology company executives” argue this point:
The American people, and indeed all people everywhere, are best served by a trusted objective regulatory process truly based on sound science, a system which can be counted upon to evaluate and act on the applications it receives without fear of political interference.
These scientists and others offer a picture of a Manichean world divided into those who are for scientific and technological progress and those who are against it—a representation of the world that we have been seeing more and more of lately in reports of a “war on science.” But drawing this line is dangerous. The real problem here is the regulatory process itself, which forces dissent to take the narrow form of challenges to scientific data and methodology and ignores other questions about what’s at stake.
The FDA approval process for the AquAdvantage salmon took longer and included more opportunities for public comment than most products the FDA reviews. This unique openness to public input was balanced by a careful parsing of what counts as scientifically and contextually relevant and what does not. The agency received 38,000 comments in response to its draft assessment alone, but it determined that just 90 were worth considering [emphases mine]. The remaining comments were discounted as irrelevant because they did not directly address the details of the regulation process, or they raised issues beyond the mandate of the agency. These disregarded comments focused on a wide range of concerns, including patenting and ownership regimes of seed and crops; how deploying genetically modified corn and soy would affect the United States’ image around the world; continuing failures of existing market configurations to address inequality and food distribution; and the long history of multinational corporations central to the commercialization of biotechnologies, such as Monsanto, intentionally obscuring the negative impacts of their chemical products and byproducts while undermining human health.
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Some might read the vast public preoccupation with a broad set of social, political, and economic issues as the contamination of science with politics. But I would suggest that this is actually a case of the reverse problem: seemingly endless conflict around the AquAdvantage salmon reflects the limitation of using narrow scientific terms to address questions of broad social, political, and economic significance. As things stand, the only legitimate way to engage in debates about the entry of the AquAdvantage salmon and other genetically modified organisms into our environments, meals, intellectual property regimes, and beyond is to contest its approval at the level of regulatory science. When the system asks the public to limit objections to narrow technical concerns, it undermines regulatory legitimacy and stultifies democratic debate—and perhaps most importantly, it contributes to the problematic discourse around science itself. When our modes of public deliberation strictly define what counts as a legitimate view on these issues, we end up portraying a good portion of the population as “against science,” when that in fact could not be further from the truth.
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To position science on one side of these debates is not only patently false but detrimental to public discourse.
… Synthetic biology is billed as having the potential to transform the world in a way that will disrupt prevailing economic and geopolitical paradigms and “reshape the very fabric of life.” The one thing both sides of the fishy debate seem to agree on is that the AquAdvantage salmon is a “pioneer” technology, and what happens to this fish could set the stage for the role that biotechnology will play in our food system in the century to come. As one commentator opined for the New York Times:
We should all be rooting for the agency to do the right thing and approve the AquAdvantage salmon. It’s a healthy and relatively cheap food source that, as global demand for fish increases, can take some pressure off our wild fish stocks. But most important, a rejection will have a chilling effect on biotechnological innovation in this country. …
This framing suggests that biotechnological innovation is a necessary and unmitigated good. But for many, the prospect of a world radically altered by biotechnology conjures past experiences in which scientific “progress” didn’t go as planned—like the devastation and political instability ushered in by nuclear weapons. Similarly, to some, a dam looks like progress, development, and economic prosperity. But to others, it looks like the violent end of a way of life, heralded by the destruction of ecosystems and entire species.
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Characterizing legitimate concerns about what kinds of technologies enter and help shape our world as “anti-science” is more likely to alienate than inspire “everyday Americans to identify with this vision of what science can do, and to believe in it.”
… perhaps we can make it productive in one way. Understanding the limitations of the process can help us think critically about how decision-making about synthetic biology going forward might be more open to a broader set of concerns and voices much earlier in the innovation process. The way forward is not drawing battle lines between those who are “for” or “against” science and closing down regulatory processes to all but the narrowest risk-based considerations. Rather, we should be forming and expanding spaces for a wide range of participants in creatively considering how to solve society’s biggest challenges. We need new ways of thinking and talking about technological promise and possibility in the world that we live in. [emphasis mine]
While Doersma is appealing to a US audience, her argument could be used internationally.
Final comments
Juma’s “Enemies of Innovation” and Keene’s “Science in Wonderland” are both worthwhile reads but it should be noted that Juma’s is the more ambitious. Keene is looking back and expanding the perspective in an area of previously mined children’s literature which hints at possible implications for our own time period..
For example, I think contemporary audiences might want to consider how much science, technology, and mathematics finds its way into our ‘fairy tales’ or super hero, space adventure, cartoons,, and other popular stories of today. Iron Man and his colleagues in one of the Avengers’ movies faced off with a robot/artificial intelligence entity, Ultron, suggesting potential existential risk; Star Trek’s impact on today’s technologies is widely acknowledged, and The Simpsons , a US animated programme, regularly embeds mathematics in its stories.
Juma examines history while attempting to extrapolate lessons for the future.It’s a courageous and worthwhile effort. While I’m not entirely comfortable with his top-down approach he knits together a comprehensive programme for policy makers and makes two point that I believe are too often overlooked, more agility is needed and these are global issues.
In celebration of an upcoming event in Vancouver (Canada), “Honey, Hives, and Poetry,” I’m including this April 17, 2015 news from David Bruggeman (on his Pasco Phronesis blog),
Tom McFadden has debuted the first video of this year’s Science Rap Academy. Seventh and eighth grade students at the Nueva School prepare a music video based on a science concept, usually reworking a rap or hip-hop song.
There are many posts on this blog about Tom McFadden and his various science rap projects (many of them courtesy of David Bruggeman/Pasco Phronesis). Here’s one of the more recent ones, a May 30, 2014 posting.
Getting back to David’s April 17, 2015 news, he also mentions the latest installment of “Science goes to the movies” which features three movies (Kingsman: The Secret Service, The Lazarus Effect, and Them!) and has Neil deGrasse Tyson as a guest. David has embedded the episode on his blog. One brief comment, it’s hard to tell how familiar Tyson or the hosts, Faith Salie and Dr. Heather Berlin are with the history of the novel or science. But the first few minutes of the conversation suggest that Mary Shelley’s Frankenstein is the first novel to demonize scientists. (I had the advantage of not getting caught up in their moment and access to search engines.) Well, novels were still pretty new in Europe and I don’t believe that there were any other novels featuring scientists prior to Mary Shelley’s work.
A brief history of novels: Japan can lay claim to the first novel, The Tale of Genji, in the 11th century CE, (The plot concerned itself with aristocratic life and romance.) Europe and its experience with the novel is a little more confusing. From the City University of New York, Brooklyn site, The Novel webpage,
The term for the novel in most European languages is roman, which suggests its closeness to the medieval romance. The English name is derived from the Italian novella, meaning “a little new thing.” Romances and novelle, short tales in prose, were predecessors of the novel, as were picaresque narratives. Picaro is Spanish for “rogue,” and the typical picaresque story is of the escapades of a rascal who lives by his wits. The development of the realistic novel owes much to such works, which were written to deflate romantic or idealized fictional forms. Cervantes’ Don Quixote (1605-15), the story of an engaging madman who tries to live by the ideals of chivalric romance, explores the role of illusion and reality in life and was the single most important progenitor of the modern novel.
The novel broke from those narrative predecessors that used timeless stories to mirror unchanging moral truths. It was a product of an intellectual milieu shaped by the great seventeenth-century philosophers, Descartes and Locke, who insisted upon the importance of individual experience. They believed that reality could be discovered by the individual through the senses. Thus, the novel emphasized specific, observed details. It individualized its characters by locating them precisely in time and space. And its subjects reflected the popular eighteenth-century concern with the social structures of everyday life.
The novel is often said to have emerged with the appearance of Daniel Defoe’s Robinson Crusoe (1719) and Moll Flanders (1722). Both are picaresque stories, in that each is a sequence of episodes held together largely because they happen to one person. But the central character in both novels is so convincing and set in so solid and specific a world that Defoe is often credited with being the first writer of “realistic” fiction. The first “novel of character” or psychological novel is Samuel Richardson’s Pamela (1740-41), an epistolary novel (or novel in which the narrative is conveyed entirely by an exchange of letters). It is a work characterized by the careful plotting of emotional states. Even more significant in this vein is Richardson’s masterpiece Clarissa (1747-48). Defoe and Richardson were the first great writers in our literature who did not take their plots from mythology, history, legend, or previous literature. They established the novel’s claim as an authentic account of the actual experience of individuals.
As far as I’m aware none of these novels are concerned with science or scientists for that matter. After all, science was still emerging from a period where alchemy reined supreme. One of the great European scientists, Isaac Newton (1642-1726/7), practiced alchemy along with his science. And that practice did not die with Newton.
With those provisos in mind, or not, do enjoy the movie reviews embedded in David’s April 17, 2015 news. One final note,David in his weekly roundup of science on late night tv noted that Neil deGrasse Tyson’s late night tv talk show, Star Talks, debuted April 20, 2015, the episode can be seen again later this week while deGrasse Tyson continues to make the rounds of other talk shows to publicize his own.
![AquaBounty's salmon (background) has been genetically modified to grow bigger and faster than a conventional Atlantic salmon of the same age (foreground.) Courtesy of AquaBounty Technologies, Inc. [downloaded from http://www.npr.org/sections/thesalt/2015/06/24/413755699/genetically-modified-salmon-coming-to-a-river-near-you]](http://www.frogheart.ca/wp-content/uploads/2015/12/GeneticallyModifiedSalmon.jpg)