Tag Archives: Mary Shelley’s Frankenstein

Mary Shelley’s Frankenstein, the scientist who may have helped inspire the story, and a poetry/science project

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Some of those early scientists were pretty wild (e.g., they experimented on themselves). This March 23, 2023 essay on The Conversation by Alexis Wolf, Research Associate on the Davy Notebooks Project, Lancaster University, and Andrew Lacey, Senior Research Associate on the Davy Notebooks Project, Lancaster University, sheds some light on one of those ‘wild ones’, Note: Links have been removed,

Sir Humphry Davy (1778–1829) is usually remembered as the inventor of a revolutionary miner’s safety lamp. But his wild popularity came as much from his influence on popular culture as it did from his contributions to chemistry and applied science.

In the first few years of the 19th century, there was no hotter spectacle in London than Davy’s lectures at the Royal Institution. The carriage traffic jams caused by his keen audience led to the introduction of London’s first one-way street.

Hundreds of members of the public, many of them women, crowded into the lecture theatre to hear the charismatic Davy speak about his cutting edge research. They would watch demonstrations of his work, which often included elaborate explosions and other breathtaking displays.

In more recent times, Davy’s star has waned. Through our work on the Davy Notebooks Project, we aim to change that. Thanks to the help of thousands of volunteers, we’re creating the first digital edition of Davy’s 83 manuscript notebooks, an exciting and important collection that we’ll soon be able to share with readers all over the world.

The first lecture Davy gave at the Royal Institution was on the subject of galvanism (the electricity generated by chemical actions). The force was thought at the time to be capable of animating matter – or of bringing something dead to life.

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That last paragraph certainly suggests the Frankenstein story as the essayists expand upon later,

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Davy’s famous lectures on the animating power of electricity at the Royal Institution may have inspired a young Mary Shelley as she came up with the idea for Frankenstein (1818), a novel that questioned the boundaries of creation using emerging scientific ideas.

Shelley may have even modelled aspects of the charming but reckless Victor Frankenstein on Davy himself. In fact, many of the things that Davy said in his lectures were borrowed word-for-word to craft the fictional scientist’s dangerous experiments.

But, as Mary Shelley probably would have known, Davy was also a writer himself with close ties to the leading authors of his day. [Mary Shelley wrote her book on a trip to Switzerland which included Lord Byron.]

He was friends with poets Lord Byron and Robert Southey and had a hand in the creation of some of the greatest works of the Romantic period. This included editing the second edition of William Wordsworth and Samuel Taylor Coleridge’s Lyrical Ballads (1800).

And he wrote his own poetry – lots of it. The pages of Davy’s dozens of surviving notebooks are crammed full of poems, both published and obscure, which share space with the complex records of his scientific experiments, alongside the notes for Davy’s jaw-dropping lectures.

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The Davy Notebooks Project, part of the Zooniverse (a citizen science web portal), has this from a researcher on its homepage,

As we see in his notebooks, Davy didn’t see the arts and the sciences as ‘two cultures’. In these manuscripts, we see poetry and chemical enquiry combined: both offered, for Davy, important ways of exploring the mysteries of the world around him.

According to the statistics on the site, the project is 96% complete but they appear to be still accepting volunteers.

Yes! Art, genetic modifications, gene editing, and xenotransplantation at the Vancouver Biennale (Canada)

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Patricia Piccinini’s Curious Imaginings Courtesy: Vancouver Biennale [downloaded from http://dailyhive.com/vancouver/vancouver-biennale-unsual-public-art-2018/]

Up to this point, I’ve been a little jealous of the Art/Sci Salon’s (Toronto, Canada) January 2018 workshops for artists and discussions about CRISPR ((clustered regularly interspaced short palindromic repeats))/Cas9 and its social implications. (See my January 10, 2018 posting for more about the events.) Now, it seems Vancouver may be in line for its ‘own’ discussion about CRISPR and the implications of gene editing. The image you saw (above) represents one of the installations being hosted by the 2018 – 2020 edition of the Vancouver Biennale.

While this posting is mostly about the Biennale and Piccinini’s work, there is a ‘science’ subsection featuring the science of CRISPR and xenotransplantation. Getting back to the Biennale and Piccinini: A major public art event since 1988, the Vancouver Biennale has hosted over 91 outdoor sculptures and new media works by more than 78 participating artists from over 25 countries and from 4 continents.

Quickie description of the 2018 – 2020 Vancouver Biennale

The latest edition of the Vancouver Biennale was featured in a June 6, 2018 news item on the Daily Hive (Vancouver),

The Vancouver Biennale will be bringing new —and unusual— works of public art to the city beginning this June.

The theme for this season’s Vancouver Biennale exhibition is “re-IMAGE-n” and it kicks off on June 20 [2018] in Vanier Park with Saudi artist Ajlan Gharem’s Paradise Has Many Gates.

Gharem’s architectural chain-link sculpture resembles a traditional mosque, the piece is meant to challenge the notions of religious orthodoxy and encourages individuals to image a space free of Islamophobia.

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Melbourne artist Patricia Piccinini’s Curious Imaginings is expected to be one of the most talked about installations of the exhibit. Her style of “oddly captivating, somewhat grotesque, human-animal hybrid creature” is meant to be shocking and thought-provoking.

Piccinini’s interactive [emphasis mine] experience will “challenge us to explore the social impacts of emerging biotechnology and our ethical limits in an age where genetic engineering and digital technologies are already pushing the boundaries of humanity.”

Piccinini’s work will be displayed in the 105-year-old Patricia Hotel in Vancouver’s Strathcona neighbourhood. The 90-day ticketed exhibition [emphasis mine] is scheduled to open this September [2018].

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Given that this blog is focused on nanotechnology and other emerging technologies such as CRISPR, I’m focusing on Piccinini’s work and its art/science or sci-art status. This image from the GOMA Gallery where Piccinini’s ‘Curious Affection‘ installation is being shown from March 24 – Aug. 5, 2018 in Brisbane, Queensland, Australia may give you some sense of what one of her installations is like,

Courtesy: Queensland Art Gallery | Gallery of Modern Art (QAGOMA)

I spoke with Serena at the Vancouver Biennale office and asked about the ‘interactive’ aspect of Piccinini’s installation. She suggested the term ‘immersive’ as an alternative. In other words, you won’t be playing with the sculptures or pressing buttons and interacting with computer screens or robots. She also noted that the ticket prices have not been set yet and they are currently developing events focused on the issues raised by the installation. She knew that 2018 is the 200th anniversary of the publication of Mary Shelley’s Frankenstein but I’m not sure how the Biennale folks plan (or don’t plan)  to integrate any recognition of the novle’s impact on the discussions about ‘new’ technologies .They expect Piccinini will visit Vancouver. (Note 1: Piccinini’s work can  also be seen in a group exhibition titled: Frankenstein’s Birthday Party at the Hosfselt Gallery in San Francisco (California, US) from June 23 – August 11, 2018.  Note 2: I featured a number of international events commemorating the 200th anniversary of the publication of Mary Shelley’s novel, Frankenstein, in my Feb. 26, 2018 posting. Note 3: The term ‘Frankenfoods’ helped to shape the discussion of genetically modified organisms and food supply on this planet. It was a wildly successful campaign for activists affecting legislation in some areas of research. Scientists have not been as enthusiastic about the effects. My January 15, 2009 posting briefly traces a history of the term.)

The 2018 – 2020 Vancouver Biennale and science

A June 7, 2018 Vancouver Biennale news release provides more detail about the current series of exhibitions,

The Biennale is also committed to presenting artwork at the cutting edge of discussion and in keeping with the STEAM (science, technology, engineering, arts, math[ematics]) approach to integrating the arts and sciences. In August [2018], Colombian/American visual artist Jessica Angel will present her monumental installation Dogethereum Bridge at Hinge Park in Olympic Village. Inspired by blockchain technology, the artwork’s design was created through the integration of scientific algorithms, new developments in technology, and the arts. This installation, which will serve as an immersive space and collaborative hub for artists and technologists, will host a series of activations with blockchain as the inspirational jumping-off point.

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In what is expected to become one of North America’s most talked-about exhibitions of the year, Melbourne artist Patricia Piccinini’s Curious Imaginings will see the intersection of art, science, and ethics. For the first time in the Biennale’s fifteen years of creating transformative experiences, and in keeping with the 2018-2020 theme of “re-IMAGE-n,” the Biennale will explore art in unexpected places by exhibiting in unconventional interior spaces.  The hyperrealist “world of oddly captivating, somewhat grotesque, human-animal hybrid creatures” will be the artist’s first exhibit in a non-museum setting, transforming a wing of the 105-year-old Patricia Hotel. Situated in Vancouver’s oldest neighbourbood of Strathcona, Piccinini’s interactive experience will “challenge us to explore the social impacts of emerging bio-technology and our ethical limits in an age where genetic engineering and digital technologies are already pushing the boundaries of humanity.” In this intimate hotel setting located in a neighborhood continually undergoing its own change, Curious Imaginings will empower visitors to personally consider questions posed by the exhibition, including the promises and consequences of genetic research and human interference. …

There are other pieces being presented at the Biennale but my special interest is in the art/sci pieces and, at this point, CRISPR.

Piccinini in more depth

You can find out more about Patricia Piccinini in her biography on the Vancouver Biennale website but I found this Char Larsson April 7, 2018 article for the Independent (UK) more informative (Note: A link has been removed),

Patricia Piccinini’s sculptures are deeply disquieting. Walking through Curious Affection, her new solo exhibition at Brisbane’s Gallery of Modern Art, is akin to entering a science laboratory full of DNA experiments. Made from silicone, fibreglass and even human hair, her sculptures are breathtakingly lifelike, however, we can’t be sure what life they are like. The artist creates an exuberant parallel universe where transgenic experiments flourish and human evolution has given way to genetic engineering and DNA splicing.

Curious Affection is a timely and welcome recognition of Piccinini’s enormous contribution to reaching back to the mid-1990s. Working across a variety of mediums including photography, video and drawing, she is perhaps best known for her hyperreal creations.

As a genre, hyperrealism depends on the skill of the artist to create the illusion of reality. To be truly successful, it must convince the spectator of its realness. Piccinini acknowledges this demand, but with a delightful twist. The excruciating attention to detail deliberately solicits our desire to look, only to generate unease, as her sculptures are imbued with a fascinating otherness. Part human, part animal, the works are uncannily familiar, but also alarmingly “other”.

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Inspired by advances in genetically modified pigs to generate replacement organs for humans [also known as xenotransplantation], we are reminded that Piccinini has always been at the forefront of debates concerning the possibilities of science, technology and DNA cloning. She does so, however, with a warm affection and sense of humour, eschewing the hysterical anxiety frequently accompanying these scientific developments.

Beyond the astonishing level of detail achieved by working with silicon and fibreglass, there is an ethics at work here. Piccinini is asking us not to avert our gaze from the other, and in doing so, to develop empathy and understanding through the encounter.

I encourage anyone who’s interested to read Larsson’s entire piece (April 7, 2018 article).

According to her Wikipedia entry, Piccinini works in a variety of media including video, sound, sculpture, and more. She also has her own website.

Gene editing and xenotransplantation

Sarah Zhang’s June 8, 2018 article for The Atlantic provides a peek at the extraordinary degree of interest and competition in the field of gene editing and CRISPR ((clustered regularly interspaced short palindromic repeats))/Cas9 research (Note: A link has been removed),

China Is Genetically Engineering Monkeys With Brain Disorders

Guoping Feng applied to college the first year that Chinese universities reopened after the Cultural Revolution. It was 1977, and more than a decade’s worth of students—5.7 million—sat for the entrance exams. Feng was the only one in his high school to get in. He was assigned—by chance, essentially—to medical school. Like most of his contemporaries with scientific ambitions, he soon set his sights on graduate studies in the United States. “China was really like 30 to 50 years behind,” he says. “There was no way to do cutting-edge research.” So in 1989, he left for Buffalo, New York, where for the first time he saw snow piled several feet high. He completed his Ph.D. in genetics at the State University of New York at Buffalo.

Feng is short and slim, with a monk-like placidity and a quick smile, and he now holds an endowed chair in neuroscience at MIT, where he focuses on the genetics of brain disorders. His 45-person lab is part of the McGovern Institute for Brain Research, which was established in 2000 with the promise of a $350 million donation, the largest ever received by the university. In short, his lab does not lack for much.

Yet Feng now travels to China several times a year, because there, he can pursue research he has not yet been able to carry out in the United States. [emphasis mine] …

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Feng had organized a symposium at SIAT [Shenzhen Institutes of Advanced Technology], and he was not the only scientist who traveled all the way from the United States to attend: He invited several colleagues as symposium speakers, including a fellow MIT neuroscientist interested in tree shrews, a tiny mammal related to primates and native to southern China, and Chinese-born neuroscientists who study addiction at the University of Pittsburgh and SUNY Upstate Medical University. Like Feng, they had left China in the ’80s and ’90s, part of a wave of young scientists in search of better opportunities abroad. Also like Feng, they were back in China to pursue a type of cutting-edge research too expensive and too impractical—and maybe too ethically sensitive—in the United States.

Here’s what precipitated Feng’s work in China, (from Zhang’s article; Note: Links have been removed)

At MIT, Feng’s lab worked on genetically engineering a monkey species called marmosets, which are very small and genuinely bizarre-looking. They are cheaper to keep due to their size, but they are a relatively new lab animal, and they can be difficult to train on lab tasks. For this reason, Feng also wanted to study Shank3 on macaques in China. Scientists have been cataloging the social behavior of macaques for decades, making it an obvious model for studies of disorders like autism that have a strong social component. Macaques are also more closely related to humans than marmosets, making their brains a better stand-in for those of humans.

The process of genetically engineering a macaque is not trivial, even with the advanced tools of CRISPR. Researchers begin by dosing female monkeys with the same hormones used in human in vitro fertilization. They then collect and fertilize the eggs, and inject the resulting embryos with CRISPR proteins using a long, thin glass needle. Monkey embryos are far more sensitive than mice embryos, and can be affected by small changes in the pH of the injection or the concentration of CRISPR proteins. Only some of the embryos will have the desired mutation, and only some will survive once implanted in surrogate mothers. It takes dozens of eggs to get to just one live monkey, so making even a few knockout monkeys required the support of a large breeding colony.

The first Shank3 macaque was born in 2015. Four more soon followed, bringing the total to five.

To visit his research animals, Feng now has to fly 8,000 miles across 12 time zones. It would be a lot more convenient to carry out his macaque research in the United States, of course, but so far, he has not been able to.

He originally inquired about making Shank3 macaques at the New England Primate Research Center, one of eight national primate research centers then funded by the National Institutes of Health in partnership with a local institution (Harvard Medical School, in this case). The center was conveniently located in Southborough, Massachusetts, just 20 miles west of the MIT campus. But in 2013, Harvard decided to shutter the center.

The decision came as a shock to the research community, and it was widely interpreted as a sign of waning interest in primate research in the United States. While the national primate centers have been important hubs of research on HIV, Zika, Ebola, and other diseases, they have also come under intense public scrutiny. Animal-rights groups like the Humane Society of the United States have sent investigators to work undercover in the labs, and the media has reported on monkey deaths in grisly detail. Harvard officially made its decision to close for “financial” reasons. But the announcement also came after the high-profile deaths of four monkeys from improper handling between 2010 and 2012. The deaths sparked a backlash; demonstrators showed up at the gates. The university gave itself two years to wind down their primate work, officially closing the center in 2015.

“They screwed themselves,” Michael Halassa, the MIT neuroscientist who spoke at Feng’s symposium, told me in Shenzhen. Wei-Dong Yao, another one of the speakers, chimed in, noting that just two years later CRISPR has created a new wave of interest in primate research. Yao was one of the researchers at Harvard’s primate center before it closed; he now runs a lab at SUNY Upstate Medical University that uses genetically engineered mouse and human stem cells, and he had come to Shenzhen to talk about restarting his addiction research on primates.

Here’s comes the competition (from Zhang’s article; Note: Links have been removed),

While the U.S. government’s biomedical research budget has been largely flat, both national and local governments in China are eager to raise their international scientific profiles, and they are shoveling money into research. A long-rumored, government-sponsored China Brain Project is supposed to give neuroscience research, and primate models in particular, a big funding boost. Chinese scientists may command larger salaries, too: Thanks to funding from the Shenzhen local government, a new principal investigator returning from overseas can get 3 million yuan—almost half a million U.S. dollars—over his or her first five years. China is even finding success in attracting foreign researchers from top U.S. institutions like Yale.

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In the past few years, China has seen a miniature explosion of genetic engineering in monkeys. In Kunming, Shanghai, and Guangzhou, scientists have created monkeys engineered to show signs of Parkinson’s, Duchenne muscular dystrophy, autism, and more. And Feng’s group is not even the only one in China to have created Shank3 monkeys. Another group—a collaboration primarily between researchers at Emory University and scientists in China—has done the same.

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Chinese scientists’ enthusiasm for CRISPR also extends to studies of humans, which are moving much more quickly, and in some cases under less oversight, than in the West. The first studies to edit human embryos and first clinical trials for cancer therapies using CRISPR have all happened in China. [emphases mine]

Some ethical issues are also covered (from Zhang’s article),

Parents with severely epileptic children had asked him if it would be possible to study the condition in a monkey. Feng told them what he thought would be technically possible. “But I also said, ‘I’m not sure I want to generate a model like this,’” he recalled. Maybe if there were a drug to control the monkeys’ seizures, he said: “I cannot see them seizure all the time.”

But is it ethical, he continued, to let these babies die without doing anything? Is it ethical to generate thousands or millions of mutant mice for studies of brain disorders, even when you know they will not elucidate much about human conditions?

Primates should only be used if other models do not work, says Feng, and only if a clear path forward is identified. The first step in his work, he says, is to use the Shank3 monkeys to identify the changes the mutations cause in the brain. Then, researchers might use that information to find targets for drugs, which could be tested in the same monkeys. He’s talking with the Oregon National Primate Research Center about carrying out similar work in the United States. ….[Note: I have a three-part series about CRISPR and germline editing* in the US, precipitated by research coming out of Oregon, Part 1, which links to the other parts, is here.]

Zhang’s June 8, 2018 article is excellent and I highly recommend reading it.

I touched on the topic of xenotransplanttaion in a commentary on a book about the science  of the television series, Orphan Black in a January 31,2018 posting (Note: A chimera is what you use to incubate a ‘human’ organ for transplantation or, more accurately, xenotransplantation),

On the subject of chimeras, the Canadian Broadcasting Corporation (CBC) featured a January 26, 2017 article about the pig-human chimeras on its website along with a video,

The end

I am very excited to see Piccinini’s work come to Vancouver. There have been a number of wonderful art and art/science installations and discussions here but this is the first one (I believe) to tackle the emerging gene editing technologies and the issues they raise. (It also fits in rather nicely with the 200th anniversary of the publication of Mary Shelley’s Frankenstein which continues to raise issues and stimulate discussion.)

In addition to the ethical issues raised in Zhang’s article, there are some other philosophical questions:

  • what does it mean to be human
  • if we are going to edit genes to create hybrid human/animals, what are they and how do they fit into our current animal/human schema
  • are you still human if you’ve had an organ transplant where the organ was incubated in a pig

There are also going to be legal issues. In addition to any questions about legal status, there are also fights about intellectual property such as the one involving Harvard & MIT’s [Massachusetts Institute of Technology] Broad Institute vs the University of California at Berkeley (March 15, 2017 posting)..

While I’m thrilled about the Piccinini installation, it should be noted the issues raised by other artworks hosted in this version of the Biennale are important. Happily, they have been broached here in Vancouver before and I suspect this will result in more nuanced  ‘conversations’ than are possible when a ‘new’ issue is introduced.

Bravo 2018 – 2020 Vancouver Biennale!

* Germline editing is when your gene editing will affect subsequent generations as opposed to editing out a mutated gene for the lifetime of a single individual.

Art/sci and CRISPR links

This art/science posting may prove of some interest:

The connectedness of living things: an art/sci project in Saskatchewan: evolutionary biology (February 16, 2018)

A selection of my CRISPR posts:

CRISPR and editing the germline in the US (part 1 of 3): In the beginning (August 15, 2017)

NOTE: An introductory CRISPR video describing how CRISPR/Cas9 works was embedded in part1.

Why don’t you CRISPR yourself? (January 25, 2018)

Editing the genome with CRISPR ((clustered regularly interspaced short palindromic repeats)-carrying nanoparticles (January 26, 2018)

Immune to CRISPR? (April 10, 2018)

Dr. Frankenstein and competitive exclusion

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A promotional photo of Boris Karloff as Frankenstein's monster, using Jack Pierce's makeup design. Credit:: Universal Studios

A promotional photo of Boris Karloff as Frankenstein’s monster, using Jack Pierce’s makeup design. Credit:: Universal Studios

An Oct. 28, 2016 news item on phys.org provides some new insight into the ‘Frankenstein story’ and its perspective on science,

Frankenstein as we know him, the grotesque monster that was created through a weird science experiment, is actually a nameless Creature created by scientist Victor Frankenstein in Mary Shelley’s 1818 novel, “Frankenstein.” Widely considered the first work of science fiction for exploring the destructive consequences of scientific and moral transgressions, a new study published in BioScience argues that the horror of Mary Shelley’s gothic novel is rooted in a fundamental principle of biology.

The co-authors point to a pivotal scene when the Creature encounters Victor Frankenstein and requests a female companion to mitigate his loneliness. The Creature distinguishes his dietary needs from those of humans and expresses a willingness to inhabit the “wilds of South America,” suggesting distinct ecological requirements. Frankenstein concedes to this reasoning given that humans would have few competitive interactions with a pair of isolated creatures, but he then reverses his decision after considering the creatures’ reproductive potential and the probability of human extinction, a concept termed competitive exclusion. In essence, Frankenstein was saving humankind.

An Oct. 28, 2016 Dartmouth College news release (also on EurekAlert) by Amy Olson, which originated the news item, describes the co-authors and the research in more detail (Note: Links have been removed),

A study co-authored by Dartmouth’s Nathaniel Dominy casts a new light on the story of Frankenstein’s monster, who lives on in the public imagination in stories, in movies, and of course, on Halloween.

Mary Shelley’s gothic novel is rooted in a fundamental principle of biology, and its horror lies in the specter of the extinction of the human race, say Dominy, a professor of anthropology, and his coauthor, Justin Yeakel.

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“The principle of competitive exclusion was not formally defined until the 1930s,” says Dominy. “Given Shelley’s early command of this foundational concept, we used computational tools developed by ecologists to explore if, and how quickly, an expanding population of creatures would drive humans to extinction.”

The authors developed a mathematical model based on human population densities in 1816, finding that the competitive advantages of creatures varied under different circumstances. The worst-case scenario for humans was a growing population of creatures in South America, as it was a region with fewer humans and therefore less competition for resources.

“We calculated that a founding population of two creatures could drive us to extinction in as little as 4,000 years,” says Dominy. Although the study is merely a thought experiment, it casts new light on the underlying horror of the novel: the extinction of the human race. It also has real-word implications for how we understand the biology of invasive species.

“To date, most scholars have focused on Mary Shelley’s knowledge of then-prevailing views on alchemy, physiology, and resurrection; however, the genius of Mary Shelley lies in how she combined and repackaged existing scientific debates to invent the genre of science fiction,” says Justin D. Yeakel, an Omidyar fellow at the Santa Fe Institute and an assistant professor in the School of Natural Sciences at the University of California, Merced.

“Our study adds to Mary Shelley’s legacy, by showing that her science fiction accurately anticipated fundamental concepts in ecology and evolution by many decades,” he says.

Here’s a link to and a citation for the paper,

Frankenstein and the Horrors of Competitive Exclusion by Nathaniel J. Dominy and Justin D. Yeakel.  BioScience (2016) doi: 10.1093/biosci/biw133 First published online: October 28, 2016

This paper is behind a paywall.

NISE Net, the acronym remains the same but the name changes

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NISE Net, the US Nanoscale Informal Science Education Network is winding down the nano and refocussing on STEM (science, technology, engineering, and mathematics). In short, NISE Net will now stand for National Informal STEM Education Network. Here’s more from the Jan. 7, 2016 NISE Net announcement in the January 2016 issue of the Nano Bite,

COMMUNITY NEWS

NISE Network is Transitioning to the National Informal STEM Education Network

Thank you for all the great work you have done over the past decade. It has opened up totally new possibilities for the decade ahead.

We are excited to let you know that with the completion of NSF funding for the Nanoscale Informal Science Education Network, and the soon-to-be-announced NASA [US National Aeronautics and Space Administration]-funded Space and Earth Informal STEM Education project, the NISE Network is transitioning to a new, ongoing identity as the National Informal STEM Education Network! While we’ll still be known as the NISE Net, network partners will now engage audiences across the United States in a range of STEM topics. Several new projects are already underway and others are in discussion for the future.

Current NISE Net projects include:

  • The original Nanoscale Informal Science Education Network (NISE Net), focusing on nanoscale science, engineering, and technology (funded by NSF and led by the Museum of Science, Boston)
  • Building with Biology, focusing on synthetic biology (funded by NSF and led by the Museum of Science with AAAS [American Association for the Advancement of Science], BioBuilder, and SynBerc [emphases mine])
  • Sustainability in Science Museums (funded by Walton Sustainability Solutions Initiatives and led by Arizona State University)
  • Transmedia Museum, focusing on science and society issues raised by Mary Shelley’s Frankenstein (funded by NSF and led by Arizona State University)
  • Space and Earth Informal STEM Education (funded by NASA and led by the Science Museum of Minnesota)

The “new” NISE Net will be led by the Science Museum of Minnesota in collaboration with the Museum of Science and Arizona State University. Network leadership, infrastructure, and participating organizations will include existing Network partners, and others attracted to the new topics. We will be in touch through the newsletter, blog, and website in the coming months to share more about our plans for the Network and its projects.

In the mean time, work is continuing with partners within the Nanoscale Informal Science Education Network throughout 2016, with an award end date of February 28, 2017. Although there will not be a new NanoDays 2016 kit, we encourage our partners to continue to engage audiences in nano by hosting NanoDays events in 2016 (March 26 – April 3) and in the years ahead using their existing kit materials. The Network will continue to host and update nisenet.org and the online catalog that includes 627 products of which 366 are NISE Net products (public and professional), 261 are Linked products, and 55 are Evaluation and Research reports. The Evaluation and Research team is continuing to work on final Network reports, and the Museum and Community Partnerships project has awarded 100 Explore Science physical kits to partners to create new or expanded collaborations with local community organizations to reach new underserved audiences not currently engaged in nano. These collaborative projects are taking place spring-summer 2016.

Thank you again for making this possible through your great work.

Best regards,

Larry Bell, Museum of Science
Paul Martin, Science Museum of Minnesota and
Rae Ostman, Arizona State University

As noted in previous posts, I’m quite interested in the synthetic biology focus the network has established in the last several months starting in late Spring 2015 and the mention of two (new-to-me) organizations, BioBuilder and Synberc piqued my interest.

I found this on the About the foundation page of the BioBuilder website,

What’s the best way to solve today’s health problems? Or hunger challenges? Address climate change concerns? Or keep the environment cleaner? These are big questions. And everyone can be part of the solutions. Everyone. Middle school students, teens, high school teachers.

At BioBuilder, we teach problem solving.
We bring current science to the classroom.
We engage our students to become real scientists — the problem solvers who will change the world.
At BioBuilder, we empower educators to be agents of educational reform by reconnecting teachers all across the country with their love of teaching and their own love of learning.

Synthetic biology programs living cells to tackle today’s challenges. Biofuels, safer foods, anti-malarial drugs, less toxic cancer treatment, biodegradable adhesives — all fuel young students’ imaginations. At BioBuilder, we empower students to tackle these big questions. BioBuilder’s curricula and teacher training capitalize on students’ need to know, to explore and to be part of solving real world problems. Developed by an award winning team out of MIT [Massachusetts Institute of Technology], BioBuilder is taught in schools across the country and supported by thought leaders in the STEM community.

BioBuilder proves that learning by doing works. And inspires.

As for Synberc, it is the Synthetic Biology Engineering Research Center and they has this to say about themselves on their About us page (Note: Links have been removed),

Synberc is a multi-university research center established in 2006 with a grant from the National Science Foundation (NSF) to help lay the foundation for synthetic biology Our mission is threefold:

develop the foundational understanding and technologies to build biological components and assemble them into integrated systems to accomplish many particular tasks;
train a new cadre of engineers who will specialize in engineering biology; and
engage the public about the opportunities and challenges of engineering biology.

Just as electrical engineers have made it possible for us to assemble computers from standardized parts (hard drives, memory cards, motherboards, and so on), we envision a day when biological engineers will be able to systematically assemble biological components such as sensors, signals, pathways, and logic gates in order to build bio-based systems that solve real-world problems in health, energy, and the environment.

In our work, we apply engineering principles to biology to develop tools that improve how fast — and how well — we can go through the design-test-build cycle. These include smart fermentation organisms that can sense their environment and adjust accordingly, and multiplex automated genome engineering, or MAGE, designed for large-scale programming and evolution of cells. We also pursue the discovery of applications that can lead to significant public benefit, such as synthetic artemisinin [emphasis mine], an anti-malaria drug that costs less and is more effective than the current plant-derived treatment.

The reference to ‘synthetic artemisinin’ caught my eye as I wrote an April 12, 2013 posting featuring this “… anti-malaria drug …” and the claim that the synthetic “… costs less and is more effective than the current plant-derived treatment” wasn’t quite the conclusion journalist, Brendan Borrell arrived at. Perhaps there’s been new research? If so, please let me know.

Please, don’t kill my hive! (a Science Rap Academy production)

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In celebration of an upcoming event in Vancouver (Canada), “Honey, Hives, and Poetry,” I’m including this April 17, 2015 news from David Bruggeman (on his Pasco Phronesis blog),

Tom McFadden has debuted the first video of this year’s Science Rap Academy.  Seventh and eighth grade students at the Nueva School prepare a music video based on a science concept, usually reworking a rap or hip-hop song.

Here’s the first installment in this year’s Science Rap Academy series, Please Don’t Kill My Hive,

There are many posts on this blog about Tom McFadden and his various science rap projects (many of them courtesy of David Bruggeman/Pasco Phronesis). Here’s one of the more recent ones, a May 30, 2014 posting.

Getting back to David’s April 17, 2015 news, he also mentions the latest installment of  “Science goes to the movies” which features three movies (Kingsman: The Secret Service, The Lazarus Effect, and Them!) and has Neil deGrasse Tyson as a guest. David has embedded the episode on his blog. One brief comment, it’s hard to tell how familiar Tyson or the hosts, Faith Salie and Dr. Heather Berlin are with the history of the novel or science. But the first few minutes of the conversation suggest that Mary Shelley’s Frankenstein is the first novel to demonize scientists. (I had the advantage of not getting caught up in their moment and access to search engines.) Well, novels were still pretty new in Europe and I don’t believe that there were any other novels featuring scientists prior to Mary Shelley’s work.

A brief history of novels: Japan can lay claim to the first novel, The Tale of Genji, in the 11th century CE, (The plot concerned itself with aristocratic life and romance.) Europe and its experience with the novel is a little more confusing. From the City University of New York, Brooklyn site, The Novel webpage,

The term for the novel in most European languages is roman, which suggests its closeness to the medieval romance. The English name is derived from the Italian novella, meaning “a little new thing.” Romances and novelle, short tales in prose, were predecessors of the novel, as were picaresque narratives. Picaro is Spanish for “rogue,” and the typical picaresque story is of the escapades of a rascal who lives by his wits. The development of the realistic novel owes much to such works, which were written to deflate romantic or idealized fictional forms. Cervantes’ Don Quixote (1605-15), the story of an engaging madman who tries to live by the ideals of chivalric romance, explores the role of illusion and reality in life and was the single most important progenitor of the modern novel.

The novel broke from those narrative predecessors that used timeless stories to mirror unchanging moral truths. It was a product of an intellectual milieu shaped by the great seventeenth-century philosophers, Descartes and Locke, who insisted upon the importance of individual experience. They believed that reality could be discovered by the individual through the senses. Thus, the novel emphasized specific, observed details. It individualized its characters by locating them precisely in time and space. And its subjects reflected the popular eighteenth-century concern with the social structures of everyday life.

The novel is often said to have emerged with the appearance of Daniel Defoe’s Robinson Crusoe (1719) and Moll Flanders (1722). Both are picaresque stories, in that each is a sequence of episodes held together largely because they happen to one person. But the central character in both novels is so convincing and set in so solid and specific a world that Defoe is often credited with being the first writer of “realistic” fiction. The first “novel of character” or psychological novel is Samuel Richardson’s Pamela (1740-41), an epistolary novel (or novel in which the narrative is conveyed entirely by an exchange of letters). It is a work characterized by the careful plotting of emotional states. Even more significant in this vein is Richardson’s masterpiece Clarissa (1747-48). Defoe and Richardson were the first great writers in our literature who did not take their plots from mythology, history, legend, or previous literature. They established the novel’s claim as an authentic account of the actual experience of individuals.

As far as I’m aware none of these novels are concerned with science or scientists for that matter. After all, science was still emerging from a period where alchemy reined supreme. One of the great European scientists, Isaac Newton (1642-1726/7), practiced alchemy along with his science. And that practice did not die with Newton.

With those provisos in mind, or not, do enjoy the movie reviews embedded in David’s April 17, 2015 news.  One final note,David in his weekly roundup of science on late night tv noted that Neil deGrasse Tyson’s late night tv talk show, Star Talks, debuted April 20, 2015, the episode can be seen again later this week while deGrasse Tyson continues to make the rounds of other talk shows to publicize his own.