Category Archives: intellectual property

Miniature, soft lithium-ion battery constructed from biocompatible hydrogel droplets for bio-integrated devices

The original headline for the University of Oxford press release was “Batteries for miniature bio-integrated devices and robotics” but it’s not clear to me what they mean by robotics (soft robots? robotic prostheses? something else?).

An October 25, 2024 news item on ScienceDaily announces the research,

University of Oxford researchers have made a significant step towards realising miniature, soft batteries for use in a variety of biomedical applications, including the defibrillation and pacing of heart tissues. The work has been published today [October 25, 2024] in the journal Nature Chemical Engineering.

An October 28, 2024 University of Oxford press release (also on EurekAlert but published October 25, 2024), which originated the lightly edited news item and posting on EurekAlert, provides more technical detail about this advance, Note: Links have been removed,

The development of tiny smart devices, smaller than a few cubic millimeters, demands equally small power sources. For minimally invasive biomedical devices that interact with biological tissues, these power sources must be fabricated from soft materials. Ideally, these should also have features such as high capacity, biocompatibility and biodegradability, triggerable activation, and the ability to be controlled remotely. To date, there has been no battery that can fulfil these requirements all at once.

To address these requirements, researchers from the University of Oxford’s Department of Chemistry and Department of Pharmacology have developed a miniature, soft lithium-ion battery constructed from biocompatible hydrogel droplets. Surfactant-supported assembly (assembly aided by soap-like molecules), a technique reported by the same group last year in the journal Nature (DOI: 10.1038/s41586-023-06295-y), is used to connect three microscale droplets of 10 nanolitres volume. Different lithium-ion particles contained in each of the two ends then generate the output energy.

‘Our droplet battery is light-activated, rechargeable, and biodegradable after use. To date, it is the smallest hydrogel lithium-ion battery and has a superior energy density’ said Dr Yujia Zhang (Department of Chemistry, University of Oxford), the lead researcher for the study and a starting Assistant Professor at the École Polytechnique Fédérale de Lausanne. ‘We used the droplet battery to power the movement of charged molecules between synthetic cells and to control the beating and defibrillation of mouse hearts. By including magnetic particles to control movement, the battery can also function as a mobile energy carrier.’

Proof-of-concept heart treatments were carried out in the laboratory of Professor Ming Lei (Department of Pharmacology), a senior electrophysiologist in cardiac arrhythmias. He said: ‘Cardiac arrhythmia is a leading cause of death worldwide. Our proof-of-concept application in animal models demonstrates an exciting new avenue of wireless and biodegradable devices for the management of arrhythmias.’

Professor Hagan Bayley (Department of Chemistry), the research group leader for the study, said: ‘The tiny soft lithium-ion battery is the most sophisticated in a series of microscale power packs developed by Dr Zhang and points to a fantastic future for biocompatible electronic devices that can operate under physiological conditions.’

The researchers have filed a patent application through Oxford University Innovation. They envisage that the tiny versatile battery, particularly relevant to small-scale robots for bioapplications, will open up new possibilities in various areas including clinical medicine.

Here’s a link to and a citation for the paper,

A microscale soft lithium-ion battery for tissue stimulation by Yujia Zhang, Tianyi Sun, Xingyun Yang, Linna Zhou, Cheryl M. J. Tan, Ming Lei & Hagan Bayley. Nature Chemical Engineering volume 1, pages 691–701 (2024) DOI: https://doi.org/10.1038/s44286-024-00136-z Published online: 25 October 2024 Issue Date: November 2024

This paper is open access.

Now, I want to highlight a few items from the paper’s introduction, Note: Links have been removed,

The miniaturization of electronic devices is a burgeoning area of research1,2,3. Therefore, the development of tiny batteries to power these devices is of critical importance, and techniques such as three-dimensional (3D) printing4,5,6 and micro-origami assembly7 [emphases mine] are beginning to have an impact. For minimally invasive applications in biomedicine, batteries are also preferred to be soft, biocompatible and biodegradable, with additional functionality and responsiveness, such as triggerable activation and remote-controlled mobility8. However, at present, such a multifunctional microscale soft battery is not available. Although hydrogel-based lithium-ion (Li-ion) batteries demonstrate some of these features9,10,11,12, none currently exhibits microscale fabrication of the battery architecture, in terms of self-assembled integration of hydrogel-based cathode, separator and anode at the submillimeter level. Manual assembly of precrosslinked compartments11 or multistep deposition and crosslinking4 is necessary to avoid the mixing of materials from different compartments at the pregel (liquid) state or during the gelation process. This limitation not only makes it difficult to shrink hydrogel-based functional architectures but also hinders the implementation of high-density energy storage.

Toward that end, Zhang et al. have reported a miniaturized ionic power source by depositing lipid-supported networks of nanoliter hydrogel droplets13. The power source mimics the electrical eel [emphasis mine] by using internal ion gradients to generate ionic current14, and can induce neuronal modulation. However, the ionic power source has several limitations [emphasis mine] that should be addressed. First, the stored salt gradient produces less power than conventional Li-ion batteries, and the device cannot be fully recharged. Second, activation of the power source relies on temperature-triggered gelation and oil for buffer exchange, which is a demanding requirement. Third, the functionality of the power source is limited to the generation of ionic output, leaving the full versatility of synthetic tissues unexploited15,16,17. Last, but not least, while the power source can modulate the activity of neural microtissues, organ-level stimulation necessitates a higher and more stable output performance in physiological environments18.

Here, we present a miniature, soft, rechargeable Li-ion droplet battery (LiDB) made by depositing self-assembling [emphasis mine], nanoliter, lipid-supported, silk hydrogel droplets. The tiny hydrogel compartmentalization produces a superior energy density. The battery is switched on by ultraviolet (UV) light, which crosslinks the hydrogel and breaks the lipid barrier between droplets. The droplets are soft, biocompatible and biodegradable. The LiDBs can power charge molecule translocation between synthetic cells, defibrillate mouse hearts with ventricular arrhythmias and pace heart rhythms. Further, the LiDB can be translocated from one site to another magnetically.

This team has integrated a number of cutting edge (I think you can still call them that) techniques such as 3D printing and origami along with inspiration from electric eels (biomimicry) for using light as a power source. .Finally, there’s self-assembly or, as it’s sometimes known, bottom-up engineering, just like nature.

This work still needs to be tested in human clinical trials but taking that into account: Bravo to the researchers!

FrogHeart’s 2024 comes to an end as 2025 comes into view

First, thank you to anyone who’s dropped by to read any of my posts. Second, I didn’t quite catch up on my backlog in what was then the new year (2024) despite my promises. (sigh) I will try to publish my drafts in a more timely fashion but I start this coming year as I did 2024 with a backlog of two to three months. This may be my new normal.

As for now, here’s an overview of FrogHeart’s 2024. The posts that follow are loosely organized under a heading but many of them could fit under other headings as well. After my informal review, there’s some material on foretelling the future as depicted in an exhibition, “Oracles, Omens and Answers,” at the Bodleian Libraries, University of Oxford.

Human enhancement: prosthetics, robotics, and more

Within a year or two of starting this blog I created a tag ‘machine/flesh’ to organize information about a number of converging technologies such as robotics, brain implants, and prosthetics that could alter our concepts of what it means to be human. The larger category of human enhancement functions in much the same way also allowing a greater range of topics to be covered.

Here are some of the 2024 human enhancement and/or machine/flesh stories on this blog,

Other species are also being rendered ‘machine/flesh’,

The year of the hydrogel?

It was the year of the hydrogel for me (btw, hydrogels are squishy materials; I have more of a description after this list),

As for anyone who’s curious about hydrogels, there’s this from an October 20, 2016 article by D.C.Demetre for ScienceBeta, Note: A link has been removed,

Hydrogels, materials that can absorb and retain large quantities of water, could revolutionise medicine. Our bodies contain up to 60% water, but hydrogels can hold up to 90%.

It is this similarity to human tissue that has led researchers to examine if these materials could be used to improve the treatment of a range of medical conditions including heart disease and cancer.

These days hydrogels can be found in many everyday products, from disposable nappies and soft contact lenses to plant-water crystals. But the history of hydrogels for medical applications started in the 1960s.

Scientists developed artificial materials with the ambitious goal of using them in permanent contact applications , ones that are implanted in the body permanently.

For anyone who wants a more technical explanation, there’s the Hydrogel entry on Wikipedia.

Science education and citizen science

Where science education is concerned I’m seeing some innovative approaches to teaching science, which can include citizen science. As for citizen science (also known as, participatory science) I’ve been noticing heightened interest at all age levels.

Artificial intelligence

It’s been another year where artificial intelligence (AI) has absorbed a lot of energy from nearly everyone. I’m highlighting the more unusual AI stories I’ve stumbled across,

As you can see, I’ve tucked in two tangentially related stories, one which references a neuromorphic computing story ((see my Neuromorphic engineering category or search for ‘memristors’ in the blog search engine for more on brain-like computing topics) and the other is intellectual property. There are many, many more stories on these topics

Art/science (or art/sci or sciart)

It’s a bit of a surprise to see how many art/sci stories were published here this year, although some might be better described as art/tech stories.

There may be more 2024 art/sci stories but the list was getting long. In addition to searching for art/sci on the blog search engine, you may want to try data sonification too.

Moving off planet to outer space

This is not a big interest of mine but there were a few stories,

A writer/blogger’s self-indulgences

Apparently books can be dangerous and not in a ‘ban [fill in the blank] from the library’ kind of way,

Then, there are these,

New uses for electricity,

Given the name for this blog, it has to be included,

  • Frog saunas published September 15, 2024, this includes what seems to be a mild scientific kerfuffle

I’ve been following Lomiko Metals (graphite mining) for a while,

Who would have guessed?

Another bacteria story,

New crimes,

Origins of life,

Dirt

While no one year features a large number of ‘dirt’ stories, it has been a recurring theme here throughout the years,

Regenerative medicine

In addition to or instead of using the ‘regenerative medicine’ tag, I might use ’tissue engineering’ or ’tissue scaffolding’,

To sum it up

It was an eclectic year.

Peering forward into 2025 and futurecasting

I expect to be delighted, horrified, thrilled, and left shaking my head by science stories in 2025. Year after year the world of science reveals a world of wonder.

More mundanely, I can state with some confidence that my commentary (mentioned in the future-oriented subsection of my 2023 review and 2024 look forward) on Quantum Potential, a 2023 report from the Council of Canadian Academies, will be published early in this new year as I’ve almost finished writing it.

As for more about the future, I’ve got this, from a December 3, 2024 essay (Five ways to predict the future from around the world – from spider divination to bibliomancy) about an exhibition by Michelle Aroney (Research Fellow in Early Modern History, University of Oxford) and David Zeitlyn (Professor of Social Anthropology, University of Oxford) in The Conversation (h/t December 3, 2024 news item on phys.org), Note: Links have been removed

Some questions are hard to answer and always have been. Does my beloved love me back? Should my country go to war? Who stole my goats?

Questions like these have been asked of diviners around the world throughout history – and still are today. From astrology and tarot to reading entrails, divination comes in a wide variety of forms.

Yet they all address the same human needs. They promise to tame uncertainty, help us make decisions or simply satisfy our desire to understand.

Anthropologists and historians like us study divination because it sheds light on the fears and anxieties of particular cultures, many of which are universal. Our new exhibition at Oxford’s Bodleian Library, Oracles, Omens & Answers, explores these issues by showcasing divination techniques from around the world.

1. Spider divination

In Cameroon, Mambila spider divination (ŋgam dù) addresses difficult questions to spiders or land crabs that live in holes in the ground.

Asking the spiders a question involves covering their hole with a broken pot and placing a stick, a stone and cards made from leaves around it. The diviner then asks a question in a yes or no format while tapping the enclosure to encourage the spider or crab to emerge. The stick and stone represent yes or no, while the leaf cards, which are specially incised with certain meanings, offer further clarification.

2. Palmistry

Reading people’s palms (palmistry) is well known as a fairground amusement, but serious forms of this divination technique exist in many cultures. The practice of reading the hands to gather insights into a person’s character and future was used in many ancient cultures across Asia and Europe.

In some traditions, the shape and depth of the lines on the palm are richest in meaning. In others, the size of the hands and fingers are also considered. In some Indian traditions, special marks and symbols appearing on the palm also provide insights.

Palmistry experienced a huge resurgence in 19th-century England and America, just as the science of fingerprints was being developed. If you could identify someone from their fingerprints, it seemed plausible to read their personality from their hands.

3. Bibliomancy

If you want a quick answer to a difficult question, you could try bibliomancy. Historically, this DIY [do-it-yourself] divining technique was performed with whatever important books were on hand.

Throughout Europe, the works of Homer or Virgil were used. In Iran, it was often the Divan of Hafiz, a collection of Persian poetry. In Christian, Muslim and Jewish traditions, holy texts have often been used, though not without controversy.

4. Astrology

Astrology exists in almost every culture around the world. As far back as ancient Babylon, astrologers have interpreted the heavens to discover hidden truths and predict the future.

5. Calendrical divination

Calendars have long been used to divine the future and establish the best times to perform certain activities. In many countries, almanacs still advise auspicious and inauspicious days for tasks ranging from getting a haircut to starting a new business deal.

In Indonesia, Hindu almanacs called pawukon [calendar] explain how different weeks are ruled by different local deities. The characteristics of the deities mean that some weeks are better than others for activities like marriage ceremonies.

You’ll find logistics for the exhibition in this September 23, 2024 Bodleian Libraries University of Oxford press release about the exhibit, Note: Links have been removed,

Oracles, Omens and Answers

6 December 2024 – 27 April 2025
ST Lee Gallery, Weston Library

The Bodleian Libraries’ new exhibition, Oracles, Omens and Answers, will explore the many ways in which people have sought answers in the face of the unknown across time and cultures. From astrology and palm reading to weather and public health forecasting, the exhibition demonstrates the ubiquity of divination practices, and humanity’s universal desire to tame uncertainty, diagnose present problems, and predict future outcomes.

Through plagues, wars and political turmoil, divination, or the practice of seeking knowledge of the future or the unknown, has remained an integral part of society. Historically, royals and politicians would consult with diviners to guide decision-making and incite action. People have continued to seek comfort and guidance through divination in uncertain times — the COVID-19 pandemic saw a rise in apps enabling users to generate astrological charts or read the Yijing [I Ching], alongside a growth in horoscope and tarot communities on social media such as ‘WitchTok’. Many aspects of our lives are now dictated by algorithmic predictions, from e-health platforms to digital advertising. Scientific forecasters as well as doctors, detectives, and therapists have taken over many of the societal roles once held by diviners. Yet the predictions of today’s experts are not immune to criticism, nor can they answer all our questions.

Curated by Dr Michelle Aroney, whose research focuses on early modern science and religion, and Professor David Zeitlyn, an expert in the anthropology of divination, the exhibition will take a historical-anthropological approach to methods of prophecy, prediction and forecasting, covering a broad range of divination methods, including astrology, tarot, necromancy, and spider divination.

Dating back as far as ancient Mesopotamia, the exhibition will show us that the same kinds of questions have been asked of specialist practitioners from around the world throughout history. What is the best treatment for this illness? Does my loved one love me back? When will this pandemic end? Through materials from the archives of the Bodleian Libraries alongside other collections in Oxford, the exhibition demonstrates just how universally human it is to seek answers to difficult questions.

Highlights of the exhibition include: oracle bones from Shang Dynasty China (ca. 1250-1050 BCE); an Egyptian celestial globe dating to around 1318; a 16th-century armillary sphere from Flanders, once used by astrologers to place the planets in the sky in relation to the Zodiac; a nineteenth-century illuminated Javanese almanac; and the autobiography of astrologer Joan Quigley, who worked with Nancy and Ronald Reagan in the White House for seven years. The casebooks of astrologer-physicians in 16th- and 17th-century England also offer rare insights into the questions asked by clients across the social spectrum, about their health, personal lives, and business ventures, and in some cases the actions taken by them in response.

The exhibition also explores divination which involves the interpretation of patterns or clues in natural things, with the idea that natural bodies contain hidden clues that can be decrypted. Some diviners inspect the entrails of sacrificed animals (known as ‘extispicy’), as evidenced by an ancient Mesopotamian cuneiform tablet describing the observation of patterns in the guts of birds. Others use human bodies, with palm readers interpreting characters and fortunes etched in their clients’ hands. A sketch of Oscar Wilde’s palms – which his palm reader believed indicated “a great love of detail…extraordinary brain power and profound scholarship” – shows the revival of palmistry’s popularity in 19th century Britain.

The exhibition will also feature a case study of spider divination practised by the Mambila people of Cameroon and Nigeria, which is the research specialism of curator Professor David Zeitlyn, himself a Ŋgam dù diviner. This process uses burrowing spiders or land crabs to arrange marked leaf cards into a pattern, which is read by the diviner. The display will demonstrate the methods involved in this process and the way in which its results are interpreted by the card readers. African basket divination has also been observed through anthropological research, where diviners receive answers to their questions in the form of the configurations of thirty plus items after they have been tossed in the basket.

Dr Michelle Aroney and Professor David Zeitlyn, co-curators of the exhibition, say:

Every day we confront the limits of our own knowledge when it comes to the enigmas of the past and present and the uncertainties of the future. Across history and around the world, humans have used various techniques that promise to unveil the concealed, disclosing insights that offer answers to private or shared dilemmas and help to make decisions. Whether a diviner uses spiders or tarot cards, what matters is whether the answers they offer are meaningful and helpful to their clients. What is fun or entertainment for one person is deadly serious for another.

Richard Ovenden, Bodley’s [a nickname? Bodleian Libraries were founded by Sir Thomas Bodley] Librarian, said:

People have tried to find ways of predicting the future for as long as we have had recorded history. This exhibition examines and illustrates how across time and culture, people manage the uncertainty of everyday life in their own way. We hope that through the extraordinary exhibits, and the scholarship that brings them together, visitors to the show will appreciate the long history of people seeking answers to life’s biggest questions, and how people have approached it in their own unique way.

The exhibition will be accompanied by the book Divinations, Oracles & Omens, edited by Michelle Aroney and David Zeitlyn, which will be published by Bodleian Library Publishing on 5 December 2024.

Courtesy: Bodleian Libraries, University of Oxford

I’m not sure why the preceding image is used to illustrate the exhibition webpage but I find it quite interesting. Should you be in Oxford, UK and lucky enough to visit the exhibition, there are a few more details on the Oracles, Omens and Answers event webpage, Note: There are 26 Bodleian Libraries at Oxford and the exhibition is being held in the Weston Library,

EXHIBITION

Oracles, Omens and Answers

6 December 2024 – 27 April 2025

ST Lee Gallery, Weston Library

Free admission, no ticket required

Note: This exhibition includes a large continuous projection of spider divination practice, including images of the spiders in action.

Exhibition tours

Oracles, Omens and Answers exhibition tours are available on selected Wednesdays and Saturdays from 1–1.45pm and are open to all.

These free gallery tours are led by our dedicated volunteer team and places are limited. Check available dates and book your tickets.

You do not need to book a tour to visit the exhibition. Please meet by the entrance doors to the exhibition at the rear of Blackwell Hall.

Happy 2025! And, once again, thank you.

A biochemical means of protecting passwords and anti-counterfeiting solution for art and other precious goods

I guess you could say my passwords are as precious to me as a piece.of art is to some people.

DNA can be used to confirm the authenticity of valuable art prints. (AI-​generated image: ETH Zurich)

An April 8, 2024 ETH Zurich press release (also on EurekAlert) by Fabio Bergamin features an approach that could make passwords secure from quantum computers, Note: A link has been removed,

Security experts fear Q-​Day, the day when quantum computers become so powerful that they can crack today’s passwords. Some experts estimate that this day will come within the next ten years. Password checks are based on cryptographic one-​way functions, which calculate an output value from an input value. This makes it possible to check the validity of a password without transmitting the password itself: the one-​way function converts the password into an output value that can then be used to check its validity in, say, online banking. What makes one-​way functions special is that it’s impossible to use their output value to deduce the input value – in other words, the password. At least not with today’s resources. However, future quantum computers could make this kind of inverse calculation easier.

Researchers at ETH Zurich have now presented a cryptographic one-​way function that works differently from today’s and will also be secure in the future. Rather than processing the data using arithmetic operations, it is stored as a sequence of nucleotides – the chemical building blocks of DNA.

Based on true randomness

“Our system is based on true randomness. The input and output values are physically linked, and it’s only possible to get from the input value to the output value, not the other way round,” explains Robert Grass, a professor in the Department of Chemistry and Applied Biosciences. “Since it’s a physical system and not a digital one, it can’t be decoded by an algorithm, not even by one that runs on a quantum computer,” adds Anne Lüscher, a doctoral student in Grass’s group. She is the lead author of the paper, which was published in the journal Nature Communications.

The researchers’ new system can serve as a counterfeit-​proof way of certifying the authenticity of valuable objects such as works of art. The technology could also be used to trace raw materials and industrial products.

How it works

The new biochemical one-​way function is based on a pool of one hundred million different DNA molecules. Each of the molecules contains two segments featuring a random sequence of nucleotides: one segment for the input value and one for the output value. There are several hundred identical copies of each of these DNA molecules in the pool, and the pool can also be divided into several pools; these are identical because they contain the same random DNA molecules. The pools can be located in different places, or they can be built into objects.

Anyone in possession of this DNA pool holds the security system’s lock. The polymerase chain reaction (PCR) can be used to test a key, or input value, which takes the form of a short sequence of nucleotides. During the PCR, this key searches the pool of hundreds of millions of DNA molecules for the molecule with the matching input value, and the PCR then amplifies the output value located on the same molecule. DNA sequencing is used to make the output value readable.

At first glance, the principle seems complicated. “However, producing DNA molecules with built-​in randomness is cheap and easy,” Grass says. The production costs for a DNA pool that can be divided up in this way are less than 1 Swiss franc. Using DNA sequencing to read out the output value is more time-​consuming and expensive, but many biology laboratories already possess the necessary equipment.

Securing valuable goods and supply chains

ETH Zurich has applied for a patent on this new technology. The researchers now want to optimise and refine it to bring it to market. Because using the method calls for specialised laboratory infrastructure, the scientists think the most likely application for this form of password verification is currently for highly sensitive goods or for access to buildings with restricted access. This technology won’t be an option for the broader public to check passwords until DNA sequencing in particular becomes easier.

A little more thought has already gone into the idea of using the technology for the forgery-​proof certification of works of art. For instance, if there are ten copies of a picture, the artist can mark them all with the DNA pool – perhaps by mixing the DNA into the paint, spraying it onto the picture or applying it to a specific spot.

If several owners later wish to have the authenticity of these artworks confirmed, they can get together, agree on a key (i.e. an input value) and carry out the DNA test. All the copies for which the test produces the same output value will have been proven genuine. The new technology could also be used to link crypto-​assets such as NFTs, which exist only in the digital world, to an object and thus to the physical world.

Furthermore, it would support counterfeit-​proof tracking along supply chains of industrial goods or raw materials. “The aviation industry, for example, has to be able to provide complete proof that it uses only original components. Our technology can guarantee traceability,” Grass says. In addition, the method could be used to label the authenticity of original medicines or cosmetics.

Here’s a link to and a citation for the paper,

Chemical unclonable functions based on operable random DNA pools by Anne M. Luescher, Andreas L. Gimpel, Wendelin J. Stark, Reinhard Heckel & Robert N. Grass. Nature Communications volume 15, Article number: 2955 (2024) DOI: https://doi.org/10.1038/s41467-024-47187-7 Published: 05 April 2024

This paper is open access.

Corporate venture capital (CVC) and the nanotechnology market plus 2023’s top 10 countries’ nanotechnolgy patents

I have two brief nanotechnology commercialization stories from the same publication.

Corporate venture capital (CVC) and the nano market

From a March 23, 2024 article on statnano.com, Note: Links have been removed,

Nanotechnology’s enormous potential across various sectors has long attracted the eye of investors, keen to capitalise on its commercial potency.

Yet the initial propulsion provided by traditional venture capital avenues was reined back when the reality of long development timelines, regulatory hurdles, and difficulty in translating scientific advances into commercially viable products became apparent.

While the initial flurry of activity declined in the early part of the 21st century, a new kid on the investing block has proved an enticing option beyond traditional funding methods.

Corporate venture capital has, over the last 10 years emerged as a key plank in turning ideas into commercial reality.

Simply put, corporate venture capital (CVC) has seen large corporations, recognising the strategic value of nanotechnology, establish their own VC arms to invest in promising start-ups.

The likes of Samsung, Johnson & Johnson and BASF have all sought to get an edge on their competition by sinking money into start-ups in nano and other technologies, which could deliver benefits to them in the long term.

Unlike traditional VC firms, CVCs invest with a strategic lens, aligning their investments with their core business goals. For instance, BASF’s venture capital arm, BASF Venture Capital, focuses on nanomaterials with applications in coatings, chemicals, and construction.

It has an evergreen EUR 250 million fund available and will consider everything from seed to Series B investment opportunities.

Samsung Ventures takes a similar approach, explaining: “Our major investment areas are in semiconductors, telecommunication, software, internet, bioengineering and the medical industry from start-ups to established companies that are about to be listed on the stock market.

While historically concentrated in North America and Europe, CVC activity in nanotechnology is expanding to Asia, with China being a major player.

China has, perhaps not surprisingly, seen considerable growth over the last decade in nano and few will bet against it being the primary driver of innovation over the next 10 years.

As ever, the long development cycles of emerging nano breakthroughs can frequently deter some CVCs with shorter investment horizons.

2023 Nanotechnology patent applications: which countries top the list?

A March 28, 2024 article from statnano.com provides interesting data concerning patent applications,

In 2023, a total of 18,526 nanotechnology patent applications were published at the United States Patent and Trademark Office (USPTO) and the European Patent Office (EPO). The United States accounted for approximately 40% of these nanotechnology patent publications, followed by China, South Korea, and Japan in the next positions.

According to a statistical analysis conducted by StatNano using data from the Orbit database, the USPTO published 84% of the 18,526 nanotechnology patent applications in 2023, which is more than five times the number published by the EPO. However, the EPO saw a nearly 17% increase in nanotechnology patent publications compared to the previous year, while the USPTO’s growth was around 4%.

Nanotechnology patents are defined based on the ISO/TS 18110 standard as those having at least one claim related to nanotechnology orpatents classified with an IPC classification code related to nanotechnology such as B82.

From the March 28, 2024 article,

Top 10 Countries Based on Published Patent Applications in the Field of Nanotechnology in USPTO in 2023

Rank1CountryNumber of nanotechnology published patent applications in USPTONumber of nanotechnology published patent applications in EPOGrowth rate in USPTOGrowth rate in EPO
1United States6,9264923.20%17.40%
2South Korea1,71547613.40%8.40%
3China1,6275694.20%47.40%
4Taiwan1,118615.00%-12.90%
5Japan1,113445-1.20%9.30%
6Germany484229-10.20%15.70%
7England331505.10%16.30%
8France323145-8.00%17.90%
9Canada290125.10%-14.30%
10Saudi Arabia268322.40%0.00%
1- Ranking based on the number of nanotechnology patent applications at the USPTO

If you have a bit of time and interest, I suggest reading the March 28, 2024 article in its entirety.

Study says quantum computing will radically alter the application of copyright law

I was expecting more speculation about the possibilities that quantum computing might afford with regard to copyright law. According to the press release, this study is primarily focused on the impact that greater computing speed and power will have on copyright and, presumably, other forms of intellectual property. From a March 4, 2024 University of Exeter press release (also on EurekAlert),

Quantum computing will radically transform the application of the law – challenging long-held notions of copyright, a new study says.

Faster computing will bring exponentially greater possibilities in the tracking and tracing of the legal owners of art, music, culture and books.  

This is likely to mean more copyright infringements, but also make it easier for lawyers to clamp down on lawbreaking. However, faster computers will also be able to potentially break and get around certain older enforcement technologies.

The research says quantum computing could lead to an “exponentially” greater number of re-uses of copyright works without permission, and tracking of anyone breaking the law is likely to be possible in many circumstances.

Dr James Griffin, from the University of Exeter [UK] Law School, who led the study, said: “Quantum computers will have sufficient computing power to be able to make judgement calls [emphasis mine] as to whether or not re-uses are likely to be copyright infringements, skirting the boundaries of the law in a way that has yet to be fully tested in practice.

“Copyright infringements could become more commonplace due to the use of quantum computers, but the enforcement of such laws could also increase. This will potentially favour certain forms of content over others.”

Content with embedded quantum watermarks will be more likely to be protected than earlier forms of content without such watermarks. The exponential speed of quantum computing brings will make it easier to be able to produce more copies of existing copyright works.

Existing artworks will be altered on a large scale for use in AI-generated artistic works. Enhanced computing power will see the reuse of elements of films such as scenes, characters, music and scripts.

Dr Griffin said: “The nature of quantum computing also means that there could be more enforcement of copyright law. we can expect that there will be more use of technological protection measures, as well as copyright management information devices such as watermarks, and more use of filtering mechanisms to be able to detect, prevent and contain copyright infringements.

Copyright management information techniques are better suited to quantum computers because they allow for more finely grained analysis of potential infringements, and because they require greater computing power to be able to be applied both broadly to computer software and the actions of the users of such software.

Dr Griffin said: “A quantum paradox [emphasis mine] is thus developing, in that there are likely to be more infringements possible, whilst technical devices will simultaneously develop in an attempt to prevent any alleged possible or potential copyright infringements. Content will increasingly be made in a manner difficult to break, with enhanced encryption.

“Meanwhile, due to the expense of large-scale quantum computing, we can expect more content to be streamed and less owned; content will be kept remotely in order to enhance the notion that utilising such data in breach of contractual terms would be akin to breaking into someone’s physical house or committing a similar fraudulent activity.

Quantum computers allow enable creators to make a large number of small-scale works. This could pose challenges regarding the tests of copyright originality. For example story written for a quantum computer game could be constantly changing and evolving according to the actions of the player, and not just simply according to predefined paths but utilising complex AI algorithms. [emphasis mine]

Some interesting issues are raised in this press release. (1) Can any computer, quantum or otherwise, make a judgment call? (2) The ‘quantum paradox’ seems like a perfectly predictable outcome. After all, regular computers facilitated all kinds of new opportunities for infringement and prevention. What makes this a ‘quantum paradox’? (3) The evolving computer game seems more like an AI issue. What makes this a quantum computing problem? The answers to these questions may be in the study but that presents a problem.

Ordinarily, I’d offer a link to the study but it’s not accessible until 2025. Here’s a citation,

Quantum Computing and Copyright Law: A Wave of Change or a Mere Irrelevant Particle? by James G. H. Griffin. Intellectual Property Quarterly 2024 Issue 1, pp. 22 – 39. Published February 21, 2024. Under embargo until 21 February 2025 [emphasis mine] in compliance with publisher policy

There is an online record for the study on this Open Research Exeter (ORE) webpage where you can request a copy of the paper.

Resurrection consent for digital cloning of the dead

It’s a bit disconcerting to think that one might be resurrected, in this case, digitally, but Dr Masaki Iwasaki has helpfully published a study on attitudes to digital cloning and resurrection consent, which could prove helpful when establishing one’s final wishes.

A January 4, 2024 De Gruyter (publisher) press release (repurposed from a January 4, 2024 blog posting on De Gruyter.com) explains the idea and the study,

In a 2014 episode of sci-fi series Black Mirror, a grieving young widow reconnects with her dead husband using an app that trawls his social media history to mimic his online language, humor and personality. It works. She finds solace in the early interactions – but soon wants more.   

Such a scenario is no longer fiction. In 2017, the company Eternime aimed to create an avatar of a dead person using their digital footprint, but this “Skype for the dead” didn’t catch on. The machine-learning and AI algorithms just weren’t ready for it. Neither were we.

Now, in 2024, amid exploding use of Chat GPT-like programs, similar efforts are on the way. But should digital resurrection be allowed at all? And are we prepared for the legal battles over what constitutes consent?

In a study published in the Asian Journal of Law and Economics, Dr Masaki Iwasaki of Harvard Law School and currently an assistant professor at Seoul National University, explores how the deceased’s consent (or otherwise) affects attitudes to digital resurrection.

US adults were presented with scenarios where a woman in her 20s dies in a car accident. A company offers to bring a digital version of her back, but her consent is, at first, ambiguous. What should her friends decide?

Two options – one where the deceased has consented to digital resurrection and another where she hasn’t – were read by participants at random. They then answered questions about the social acceptability of bringing her back on a five-point rating scale, considering other factors such as ethics and privacy concerns.

Results showed that expressed consent shifted acceptability two points higher compared to dissent. “Although I expected societal acceptability for digital resurrection to be higher when consent was expressed, the stark difference in acceptance rates – 58% for consent versus 3% for dissent – was surprising,” says Iwasaki. “This highlights the crucial role of the deceased’s wishes in shaping public opinion on digital resurrection.”

In fact, 59% of respondents disagreed with their own digital resurrection, and around 40% of respondents did not find any kind of digital resurrection socially acceptable, even with expressed consent. “While the will of the deceased is important in determining the societal acceptability of digital resurrection, other factors such as ethical concerns about life and death, along with general apprehension towards new technology are also significant,” says Iwasaki.  

The results reflect a discrepancy between existing law and public sentiment. People’s general feelings – that the dead’s wishes should be respected – are actually not protected in most countries. The digitally recreated John Lennon in the film Forrest Gump, or animated hologram of Amy Winehouse reveal the ‘rights’ of the dead are easily overridden by those in the land of the living.

So, is your digital destiny something to consider when writing your will? It probably should be but in the current absence of clear legal regulations on the subject, the effectiveness of documenting your wishes in such a way is uncertain. For a start, how such directives are respected varies by legal jurisdiction. “But for those with strong preferences documenting their wishes could be meaningful,” says Iwasaki. “At a minimum, it serves as a clear communication of one’s will to family and associates, and may be considered when legal foundations are better established in the future.”

It’s certainly a conversation worth having now. Many generative AI chatbot services, such as like Replika (“The AI companion who cares”) and Project December (“Simulate the dead”) already enable conversations with chatbots replicating real people’s personalities. The service ‘You, Only Virtual’ (YOV) allows users to upload someone’s text messages, emails and voice conversations to create a ‘versona’ chatbot. And, in 2020, Microsoft obtained a patent to create chatbots from text, voice and image data for living people as well as for historical figures and fictional characters, with the option of rendering in 2D or 3D.

Iwasaki says he’ll investigate this and the digital resurrection of celebrities in future research. “It’s necessary first to discuss what rights should be protected, to what extent, then create rules accordingly,” he explains. “My research, building upon prior discussions in the field, argues that the opt-in rule requiring the deceased’s consent for digital resurrection might be one way to protect their rights.”

There is a link to the study in the press release above but this includes a citation, of sorts,

Digital Cloning of the Dead: Exploring the Optimal Default Rule by Masaki Iwasaki. Asian Journal of Law and Economics DOI: https://doi.org/10.1515/ajle-2023-0125 Published Online: 2023-12-27

This paper is open access.

Brain-inspired (neuromrophic) computing with twisted magnets and a patent for manufacturing permanent magnets without rare earths

I have two news bits both of them concerned with magnets.

Patent for magnets that can be made without rare earths

I’m starting with the patent news first since this is (as the company notes in its news release) a “Landmark Patent Issued for Technology Critically Needed to Combat Chinese Monopoly.”

For those who don’t know, China supplies most of the rare earths used in computers, smart phones, and other devices. On general principles, having a single supplier dominate production of and access to a necessary material for devices that most of us rely on can raise tensions. Plus, you can’t mine for resources forever.

This December 19, 2023 Nanocrystal Technology LP news release heralds an exciting development (for the impatient, further down the page I have highlighted the salient sections),

Nanotechnology Discovery by 2023 Nobel Prize Winner Became Launch Pad to Create Permanent Magnets without Rare Earths from China

NEW YORK, NY, UNITED STATES, December 19, 2023 /EINPresswire.com/ — Integrated Nano-Magnetics Corp, a wholly owned subsidiary of Nanocrystal Technology LP, was awarded a patent for technology built upon a fundamental nanoscience discovery made by Aleksey Yekimov, its former Chief Scientific Officer.

This patent will enable the creation of strong permanent magnets which are critically needed for both industrial and military applications but cannot be manufactured without certain “rare earth” elements available mostly from China.

At a glittering awards ceremony held in Stockholm on December10, 2023, three scientists, Aleksey Yekimov, Louis Brus (Professor at Columbia University) and Moungi Bawendi (Professor at MIT) were honored with the Nobel Prize in Chemistry for their discovery of the “quantum dot” which is now fueling practical applications in tuning the colors of LEDs, increasing the resolution of TV screens, and improving MRI imaging.

As stated by the Royal Swedish Academy of Sciences, “Quantum dots are … bringing the greatest benefits to humankind. Researchers believe that in the future they could contribute to flexible electronics, tiny sensors, thinner solar cells, and encrypted quantum communications – so we have just started exploring the potential of these tiny particles.”

Aleksey Yekimov worked for over 19 years until his retirement as Chief Scientific Officer of Nanocrystals Technology LP, an R & D company in New York founded by two Indian-American entrepreneurs, Rameshwar Bhargava and Rajan Pillai.

Yekimov, who was born in Russia, had already received the highest scientific honors for his work before he immigrated to USA in 1999. Yekimov was greatly intrigued by Nanocrystal Technology’s research project and chose to join the company as its Chief Scientific Officer.

During its early years, the company worked on efficient light generation by doping host nanoparticles about the same size as a quantum dot with an additional impurity atom. Bhargava came up with the novel idea of incorporating a single impurity atom, a dopant, into a quantum dot sized host, and thus achieve an extraordinary change in the host material’s properties such as inducing strong permanent magnetism in weak, readily available paramagnetic materials. To get a sense of the scale at which nanotechnology works, and as vividly illustrated by the Nobel Foundation, the difference in size between a quantum dot and a soccer ball is about the same as the difference between a soccer ball and planet Earth.

Currently, strong permanent magnets are manufactured from “rare earths” available mostly in China which has established a near monopoly on the supply of rare-earth based strong permanent magnets. Permanent magnets are a fundamental building block for electro-mechanical devices such as motors found in all automobiles including electric vehicles, trucks and tractors, military tanks, wind turbines, aircraft engines, missiles, etc. They are also required for the efficient functioning of audio equipment such as speakers and cell phones as well as certain magnetic storage media.

The existing market for permanent magnets is $28 billion and is projected to reach $50 billion by 2030 in view of the huge increase in usage of electric vehicles. China’s overwhelming dominance in this field has become a matter of great concern to governments of all Western and other industrialized nations. As the Wall St. Journal put it, China’s now has a “stranglehold” on the economies and security of other countries.

The possibility of making permanent magnets without the use of any rare earths mined in China has intrigued leading physicists and chemists for nearly 30 years. On December 19, 2023, a U.S. patent with the title ‘’Strong Non Rare Earth Permanent Magnets from Double Doped Magnetic Nanoparticles” was granted to Integrated Nano-Magnetics Corp. [emphasis mine] Referring to this major accomplishment Bhargava said, “The pioneering work done by Yekimov, Brus and Bawendi has provided the foundation for us to make other discoveries in nanotechnology which will be of great benefit to the world.”

I was not able to find any company websites. The best I could find is a Nanocrystals Technology LinkedIn webpage and some limited corporate data for Integrated Nano-Magnetics on opencorporates.com.

Twisted magnets and brain-inspired computing

This research offers a pathway to neuromorphic (brainlike) computing with chiral (or twisted) magnets, which, as best as I understand it, do not require rare earths. From a November13, 2023 news item on ScienceDaily,

A form of brain-inspired computing that exploits the intrinsic physical properties of a material to dramatically reduce energy use is now a step closer to reality, thanks to a new study led by UCL [University College London] and Imperial College London [ICL] researchers.

In the new study, published in the journal Nature Materials, an international team of researchers used chiral (twisted) magnets as their computational medium and found that, by applying an external magnetic field and changing temperature, the physical properties of these materials could be adapted to suit different machine-learning tasks.

A November 9, 2023 UCL press release (also on EurekAlert but published November 13, 2023), which originated the news item, fill s in a few more details about the research,

Dr Oscar Lee (London Centre for Nanotechnology at UCL and UCL Department of Electronic & Electrical Engineering), the lead author of the paper, said: “This work brings us a step closer to realising the full potential of physical reservoirs to create computers that not only require significantly less energy, but also adapt their computational properties to perform optimally across various tasks, just like our brains.

“The next step is to identify materials and device architectures that are commercially viable and scalable.”

Traditional computing consumes large amounts of electricity. This is partly because it has separate units for data storage and processing, meaning information has to be shuffled constantly between the two, wasting energy and producing heat. This is particularly a problem for machine learning, which requires vast datasets for processing. Training one large AI model can generate hundreds of tonnes of carbon dioxide.

Physical reservoir computing is one of several neuromorphic (or brain inspired) approaches that aims to remove the need for distinct memory and processing units, facilitating more efficient ways to process data. In addition to being a more sustainable alternative to conventional computing, physical reservoir computing could be integrated into existing circuitry to provide additional capabilities that are also energy efficient.

In the study, involving researchers in Japan and Germany, the team used a vector network analyser to determine the energy absorption of chiral magnets at different magnetic field strengths and temperatures ranging from -269 °C to room temperature.

They found that different magnetic phases of chiral magnets excelled at different types of computing task. The skyrmion phase, where magnetised particles are swirling in a vortex-like pattern, had a potent memory capacity apt for forecasting tasks. The conical phase, meanwhile, had little memory, but its non-linearity was ideal for transformation tasks and classification – for instance, identifying if an animal is a cat or dog.

Co-author Dr Jack Gartside, of Imperial College London, said: “Our collaborators at UCL in the group of Professor Hidekazu Kurebayashi recently identified a promising set of materials for powering unconventional computing. These materials are special as they can support an especially rich and varied range of magnetic textures. Working with the lead author Dr Oscar Lee, the Imperial College London group [led by Dr Gartside, Kilian Stenning and Professor Will Branford] designed a neuromorphic computing architecture to leverage the complex material properties to match the demands of a diverse set of challenging tasks. This gave great results, and showed how reconfiguring physical phases can directly tailor neuromorphic computing performance.”

The work also involved researchers at the University of Tokyo and Technische Universität München and was supported by the Leverhulme Trust, Engineering and Physical Sciences Research Council (EPSRC), Imperial College London President’s Excellence Fund for Frontier Research, Royal Academy of Engineering, the Japan Science and Technology Agency, Katsu Research Encouragement Award, Asahi Glass Foundation, and the DFG (German Research Foundation).

Here’s a link to and a citation for the paper,

Task-adaptive physical reservoir computing by Oscar Lee, Tianyi Wei, Kilian D. Stenning, Jack C. Gartside, Dan Prestwood, Shinichiro Seki, Aisha Aqeel, Kosuke Karube, Naoya Kanazawa, Yasujiro Taguchi, Christian Back, Yoshinori Tokura, Will R. Branford & Hidekazu Kurebayashi. Nature Materials volume 23, pages 79–87 (2024) DOI: https://doi.org/10.1038/s41563-023-01698-8 Published online: 13 November 2023 Issue Date: January 2024

This paper is open access.

FrogHeart’s 2023 comes to an end as 2024 comes into view

My personal theme for this last year (2023) and for the coming year was and is: catching up. On the plus side, my 2023 backlog (roughly six months) to be published was whittled down considerably. On the minus side, I start 2024 with a backlog of two to three months.

2023 on this blog had a lot in common with 2022 (see my December 31, 2022 posting), which may be due to what’s going on in the world of emerging science and technology or to my personal interests or possibly a bit of both. On to 2023 and a further blurring of boundaries:

Energy, computing and the environment

The argument against paper is that it uses up resources, it’s polluting, it’s affecting the environment, etc. Somehow the part where electricity which underpins so much of our ‘smart’ society does the same thing is left out of the discussion.

Neuromorphic (brainlike) computing and lower energy

Before launching into the stories about lowering energy usage, here’s an October 16, 2023 posting “The cost of building ChatGPT” that gives you some idea of the consequences of our insatiable desire for more computing and more ‘smart’ devices,

In its latest environmental report, Microsoft disclosed that its global water consumption spiked 34% from 2021 to 2022 (to nearly 1.7 billion gallons , or more than 2,500 Olympic-sized swimming pools), a sharp increase compared to previous years that outside researchers tie to its AI research. [emphases mine]

“It’s fair to say the majority of the growth is due to AI,” including “its heavy investment in generative AI and partnership with OpenAI,” said Shaolei Ren, [emphasis mine] a researcher at the University of California, Riverside who has been trying to calculate the environmental impact of generative AI products such as ChatGPT.

Why it matters: Microsoft’s five WDM [West Des Moines in Iowa] data centers — the “epicenter for advancing AI” — represent more than $5 billion in investments in the last 15 years.

Yes, but: They consumed as much as 11.5 million gallons of water a month for cooling, or about 6% of WDM’s total usage during peak summer usage during the last two years, according to information from West Des Moines Water Works.

The focus is AI but it doesn’t take long to realize that all computing has energy and environmental costs. I have more about Ren’s work and about water shortages in the “The cost of building ChatGPT” posting.

This next posting would usually be included with my other art/sci postings but it touches on the issues. My October 13, 2023 posting about Toronto’s Art/Sci Salon events, in particular, there’s the Streaming Carbon Footprint event (just scroll down to the appropriate subhead). For the interested, I also found this 2022 paper “The Carbon Footprint of Streaming Media:; Problems, Calculations, Solutions” co-authored by one of the artist/researchers (Laura U. Marks, philosopher and scholar of new media and film at Simon Fraser University) who presented at the Toronto event.

I’m late to the party; Thomas Daigle posted a January 2, 2020 article about energy use and our appetite for computing and ‘smart’ devices for the Canadian Broadcasting Corporation’s online news,

For those of us binge-watching TV shows, installing new smartphone apps or sharing family photos on social media over the holidays, it may seem like an abstract predicament.

The gigabytes of data we’re using — although invisible — come at a significant cost to the environment. Some experts say it rivals that of the airline industry. 

And as more smart devices rely on data to operate (think internet-connected refrigerators or self-driving cars), their electricity demands are set to skyrocket.

“We are using an immense amount of energy to drive this data revolution,” said Jane Kearns, an environment and technology expert at MaRS Discovery District, an innovation hub in Toronto.

“It has real implications for our climate.”

Some good news

Researchers are working on ways to lower the energy and environmental costs, here’s a sampling of 2023 posts with an emphasis on brainlike computing that attest to it,

If there’s an industry that can make neuromorphic computing and energy savings sexy, it’s the automotive indusry,

On the energy front,

Most people are familiar with nuclear fission and some its attendant issues. There is an alternative nuclear energy, fusion, which is considered ‘green’ or greener anyway. General Fusion is a local (Vancouver area) company focused on developing fusion energy, alongside competitors from all over the planet.

Part of what makes fusion energy attractive is that salt water or sea water can be used in its production and, according to that December posting, there are other applications for salt water power,

More encouraging developments in environmental science

Again, this is a selection. You’ll find a number of nano cellulose research projects and a couple of seaweed projects (seaweed research seems to be of increasing interest).

All by myself (neuromorphic engineering)

Neuromorphic computing is a subset of neuromorphic engineering and I stumbled across an article that outlines the similarities and differences. My ‘summary’ of the main points and a link to the original article can be found here,

Oops! I did it again. More AI panic

I included an overview of the various ‘recent’ panics (in my May 25, 2023 posting below) along with a few other posts about concerning developments but it’s not all doom and gloom..

Governments have realized that regulation might be a good idea. The European Union has a n AI act, the UK held an AI Safety Summit in November 2023, the US has been discussing AI regulation with its various hearings, and there’s impending legislation in Canada (see professor and lawyer Michael Geist’s blog for more).

A long time coming, a nanomedicine comeuppance

Paolo Macchiarini is now infamous for his untested, dangerous approach to medicine. Like a lot of people, I was fooled too as you can see in my August 2, 2011 posting, “Body parts nano style,”

In early July 2011, there were reports of a new kind of transplant involving a body part made of a biocomposite. Andemariam Teklesenbet Beyene underwent a trachea transplant that required an artificial windpipe crafted by UK experts then flown to Sweden where Beyene’s stem cells were used to coat the windpipe before being transplanted into his body.

It is an extraordinary story not least because Beyene, a patient in a Swedish hospital planning to return to Eritrea after his PhD studies in Iceland, illustrates the international cooperation that made the transplant possible.

The scaffolding material for the artificial windpipe was developed by Professor Alex Seifalian at the University College London in a landmark piece of nanotechnology-enabled tissue engineering. …

Five years later I stumbled across problems with Macchiarini’s work as outlined in my April 19, 2016 posting, “Macchiarini controversy and synthetic trachea transplants (part 1 of 2)” and my other April 19, 2016 posting, “Macchiarini controversy and synthetic trachea transplants (part 2 of 2)“.

This year, Gretchen Vogel (whose work was featured in my 2016 posts) has written a June 21, 2023 update about the Macchiarini affair for Science magazine, Note: Links have been removed,

Surgeon Paolo Macchiarini, who was once hailed as a pioneer of stem cell medicine, was found guilty of gross assault against three of his patients today and sentenced to 2 years and 6 months in prison by an appeals court in Stockholm. The ruling comes a year after a Swedish district court found Macchiarini guilty of bodily harm in two of the cases and gave him a suspended sentence. After both the prosecution and Macchiarini appealed that ruling, the Svea Court of Appeal heard the case in April and May. Today’s ruling from the five-judge panel is largely a win for the prosecution—it had asked for a 5-year sentence whereas Macchiarini’s lawyer urged the appeals court to acquit him of all charges.

Macchiarini performed experimental surgeries on the three patients in 2011 and 2012 while working at the renowned Karolinska Institute. He implanted synthetic windpipes seeded with stem cells from the patients’ own bone marrow, with the hope the cells would multiply over time and provide an enduring replacement. All three patients died when the implants failed. One patient died suddenly when the implant caused massive bleeding just 4 months after it was implanted; the two others survived for 2.5 and nearly 5 years, respectively, but suffered painful and debilitating complications before their deaths.

In the ruling released today, the appeals judges disagreed with the district court’s decision that the first two patients were treated under “emergency” conditions. Both patients could have survived for a significant length of time without the surgeries, they said. The third case was an “emergency,” the court ruled, but the treatment was still indefensible because by then Macchiarini was well aware of the problems with the technique. (One patient had already died and the other had suffered severe complications.)

A fictionalized tv series ( part of the Dr. Death anthology series) based on Macchiarini’s deceptions and a Dr. Death documentary are being broadcast/streamed in the US during January 2024. These come on the heels of a November 2023 Macchiarini documentary also broadcast/streamed on US television.

Dr. Death (anthology), based on the previews I’ve seen, is heavily US-centric, which is to be expected since Adam Ciralsky is involved in the production. Ciralsky wrote an exposé about Macchiarini for Vanity Fair published in 2016 (also featured in my 2016 postings). From a December 20, 2023 article by Julie Miller for Vanity Fair, Note: A link has been removed,

Seven years ago [2016], world-renowned surgeon Paolo Macchiarini was the subject of an ongoing Vanity Fair investigation. He had seduced award-winning NBC producer Benita Alexander while she was making a special about him, proposed, and promised her a wedding officiated by Pope Francis and attended by political A-listers. It was only after her designer wedding gown was made that Alexander learned Macchiarini was still married to his wife, and seemingly had no association with the famous names on their guest list.

Vanity Fair contributor Adam Ciralsky was in the midst of reporting the story for this magazine in the fall of 2015 when he turned to Dr. Ronald Schouten, a Harvard psychiatry professor. Ciralsky sought expert insight into the kind of fabulist who would invent and engage in such an audacious lie.

“I laid out the story to him, and he said, ‘Anybody who does this in their private life engages in the same conduct in their professional life,” recalls Ciralsky, in a phone call with Vanity Fair. “I think you ought to take a hard look at his CVs.”

That was the turning point in the story for Ciralsky, a former CIA lawyer who soon learned that Macchiarini was more dangerous as a surgeon than a suitor. …

Here’s a link to Ciralsky’s original article, which I described this way, from my April 19, 2016 posting (part 2 of the Macchiarini controversy),

For some bizarre frosting on this disturbing cake (see part 1 of the Macchiarini controversy and synthetic trachea transplants for the medical science aspects), a January 5, 2016 Vanity Fair article by Adam Ciralsky documents Macchiarini’s courtship of an NBC ([US] National Broadcasting Corporation) news producer who was preparing a documentary about him and his work.

[from Ciralsky’s article]

“Macchiarini, 57, is a magnet for superlatives. He is commonly referred to as “world-renowned” and a “super-surgeon.” He is credited with medical miracles, including the world’s first synthetic organ transplant, which involved fashioning a trachea, or windpipe, out of plastic and then coating it with a patient’s own stem cells. That feat, in 2011, appeared to solve two of medicine’s more intractable problems—organ rejection and the lack of donor organs—and brought with it major media exposure for Macchiarini and his employer, Stockholm’s Karolinska Institute, home of the Nobel Prize in Physiology or Medicine. Macchiarini was now planning another first: a synthetic-trachea transplant on a child, a two-year-old Korean-Canadian girl named Hannah Warren, who had spent her entire life in a Seoul hospital. … “

Other players in the Macchiarini story

Pierre Delaere, a trachea expert and professor of head and neck surgery at KU Leuven (a university in Belgium) was one of the first to draw attention to Macchiarini’s dangerous and unethical practices. To give you an idea of how difficult it was to get attention for this issue, there’s a September 1, 2017 article by John Rasko and Carl Power for the Guardian illustrating the issue. Here’s what they had to say about Delaere and other early critics of the work, Note: Links have been removed,

Delaere was one of the earliest and harshest critics of Macchiarini’s engineered airways. Reports of their success always seemed like “hot air” to him. He could see no real evidence that the windpipe scaffolds were becoming living, functioning airways – in which case, they were destined to fail. The only question was how long it would take – weeks, months or a few years.

Delaere’s damning criticisms appeared in major medical journals, including the Lancet, but weren’t taken seriously by Karolinska’s leadership. Nor did they impress the institute’s ethics council when Delaere lodged a formal complaint. [emphases mine]

Support for Macchiarini remained strong, even as his patients began to die. In part, this is because the field of windpipe repair is a niche area. Few people at Karolinska, especially among those in power, knew enough about it to appreciate Delaere’s claims. Also, in such a highly competitive environment, people are keen to show allegiance to their superiors and wary of criticising them. The official report into the matter dubbed this the “bandwagon effect”.

With Macchiarini’s exploits endorsed by management and breathlessly reported in the media, it was all too easy to jump on that bandwagon.

And difficult to jump off. In early 2014, four Karolinska doctors defied the reigning culture of silence [emphasis mine] by complaining about Macchiarini. In their view, he was grossly misrepresenting his results and the health of his patients. An independent investigator agreed. But the vice-chancellor of Karolinska Institute, Anders Hamsten, wasn’t bound by this judgement. He officially cleared Macchiarini of scientific misconduct, allowing merely that he’d sometimes acted “without due care”.

For their efforts, the whistleblowers were punished. [emphasis mine] When Macchiarini accused one of them, Karl-Henrik Grinnemo, of stealing his work in a grant application, Hamsten found him guilty. As Grinnemo recalls, it nearly destroyed his career: “I didn’t receive any new grants. No one wanted to collaborate with me. We were doing good research, but it didn’t matter … I thought I was going to lose my lab, my staff – everything.”

This went on for three years until, just recently [2017], Grinnemo was cleared of all wrongdoing.

It is fitting that Macchiarini’s career unravelled at the Karolinska Institute. As the home of the Nobel prize in physiology or medicine, one of its ambitions is to create scientific celebrities. Every year, it gives science a show-business makeover, picking out from the mass of medical researchers those individuals deserving of superstardom. The idea is that scientific progress is driven by the genius of a few.

It’s a problematic idea with unfortunate side effects. A genius is a revolutionary by definition, a risk-taker and a law-breaker. Wasn’t something of this idea behind the special treatment Karolinska gave Macchiarini? Surely, he got away with so much because he was considered an exception to the rules with more than a whiff of the Nobel about him. At any rate, some of his most powerful friends were themselves Nobel judges until, with his fall from grace, they fell too.

The September 1, 2017 article by Rasko and Power is worth the read if you have the interest and the time. And, Delaere has written up a comprehensive analysis, which includes basic information about tracheas and more, “The Biggest Lie in Medical History” 2020, PDF, 164 pp., Creative Commons Licence).

I also want to mention Leonid Schneider, science journalist and molecular cell biologist, whose work the Macchiarini scandal on his ‘For Better Science’ website was also featured in my 2016 pieces. Schneider’s site has a page titled, ‘Macchiarini’s trachea transplant patients: the full list‘ started in 2017 and which he continues to update with new information about the patients. The latest update was made on December 20, 2023.

Promising nanomedicine research but no promises and a caveat

Most of the research mentioned here is still in the laboratory. i don’t often come across work that has made its way to clinical trials since the focus of this blog is emerging science and technology,

*If you’re interested in the business of neurotechnology, the July 17, 2023 posting highlights a very good UNESCO report on the topic.

Funky music (sound and noise)

I have couple of stories about using sound for wound healing, bioinspiration for soundproofing applications, detecting seismic activity, more data sonification, etc.

Same old, same old CRISPR

2023 was relatively quiet (no panics) where CRISPR developments are concerned but still quite active.

Art/Sci: a pretty active year

I didn’t realize how active the year was art/sciwise including events and other projects until I reviewed this year’s postings. This is a selection from 2023 but there’s a lot more on the blog, just use the search term, “art/sci,” or “art/science,” or “sciart.”

While I often feature events and projects from these groups (e.g., June 2, 2023 posting, “Metacreation Lab’s greatest hits of Summer 2023“), it’s possible for me to miss a few. So, you can check out Toronto’s Art/Sci Salon’s website (strong focus on visual art) and Simon Fraser University’s Metacreation Lab for Creative Artificial Intelligence website (strong focus on music).

My selection of this year’s postings is more heavily weighted to the ‘writing’ end of things.

Boundaries: life/nonlife

Last year I subtitled this section, ‘Aliens on earth: machinic biology and/or biological machinery?” Here’s this year’s selection,

Canada’s 2023 budget … military

2023 featured an unusual budget where military expenditures were going to be increased, something which could have implications for our science and technology research.

Then things changed as Murray Brewster’s November 21, 2023 article for the Canadian Broadcasting Corporation’s (CBC) news online website comments, Note: A link has been removed,

There was a revelatory moment on the weekend as Defence Minister Bill Blair attempted to bridge the gap between rhetoric and reality in the Liberal government’s spending plans for his department and the Canadian military.

Asked about an anticipated (and long overdue) update to the country’s defence policy (supposedly made urgent two years ago by Russia’s full-on invasion of Ukraine), Blair acknowledged that the reset is now being viewed through a fiscal lens.

“We said we’re going to bring forward a new defence policy update. We’ve been working through that,” Blair told CBC’s Rosemary Barton Live on Sunday.

“The current fiscal environment that the country faces itself does require (that) that defence policy update … recognize (the) fiscal challenges. And so it’ll be part of … our future budget processes.”

One policy goal of the existing defence plan, Strong, Secure and Engaged, was to require that the military be able to concurrently deliver “two sustained deployments of 500 [to] 1,500 personnel in two different theaters of operation, including one as a lead nation.”

In a footnote, the recent estimates said the Canadian military is “currently unable to conduct multiple operations concurrently per the requirements laid out in the 2017 Defence Policy. Readiness of CAF force elements has continued to decrease over the course of the last year, aggravated by decreasing number of personnel and issues with equipment and vehicles.”

Some analysts say they believe that even if the federal government hits its overall budget reduction targets, what has been taken away from defence — and what’s about to be taken away — won’t be coming back, the minister’s public assurances notwithstanding.

10 years: Graphene Flagship Project and Human Brain Project

Graphene and Human Brain Project win biggest research award in history (& this is the 2000th post)” on January 28, 2013 was how I announced the results of what had been a a European Union (EU) competition that stretched out over several years and many stages as projects were evaluated and fell to the wayside or were allowed onto the next stage. The two finalists received €1B each to be paid out over ten years.

Future or not

As you can see, there was plenty of interesting stuff going on in 2023 but no watershed moments in the areas I follow. (Please do let me know in the Comments should you disagree with this or any other part of this posting.) Nanotechnology seems less and less an emerging science/technology in itself and more like a foundational element of our science and technology sectors. On that note, you may find my upcoming (in 2024) post about a report concerning the economic impact of its National Nanotechnology Initiative (NNI) from 2002 to 2022 of interest.

Following on the commercialization theme, I have noticed an increase of interest in commercializing brain and brainlike engineering technologies, as well as, more discussion about ethics.

Colonizing the brain?

UNESCO held events such as, this noted in my July 17, 2023 posting, “Unveiling the Neurotechnology Landscape: Scientific Advancements, Innovations and Major Trends—a UNESCO report” and this noted in my July 7, 2023 posting “Global dialogue on the ethics of neurotechnology on July 13, 2023 led by UNESCO.” An August 21, 2023 posting, “Ethical nanobiotechnology” adds to the discussion.

Meanwhile, Australia has been producing some very interesting mind/robot research, my June 13, 2023 posting, “Mind-controlled robots based on graphene: an Australian research story.” I have more of this kind of research (mind control or mind reading) from Australia to be published in early 2024. The Australians are not alone, there’s also this April 12, 2023 posting, “Mind-reading prosthetic limbs” from Germany.

My May 12, 2023 posting, “Virtual panel discussion: Canadian Strategies for Responsible Neurotechnology Innovation on May 16, 2023” shows Canada is entering the discussion. Unfortunately, the Canadian Science Policy Centre (CSPC), which held the event, has not posted a video online even though they have a youtube channel featuring other of their events.

As for neurmorphic engineering, China has produced a roadmap for its research in this area as noted in my March 20, 2023 posting, “A nontraditional artificial synaptic device and roadmap for Chinese research into neuromorphic devices.”

Quantum anybody?

I haven’t singled it out in this end-of-year posting but there is a great deal of interest in quantum computer both here in Canada and elsewhere. There is a 2023 report from the Council of Canadian Academies on the topic of quantum computing in Canada, which I hope to comment on soon.

Final words

I have a shout out for the Canadian Science Policy Centre, which celebrated its 15th anniversary in 2023. Congratulations!

For everyone, I wish peace on earth and all the best for you and yours in 2024!

Canadian Science Policy Centre panel on Sept. 6, 2023 [date changed to October 4, 2023]: Science, technology and innovation (STI) between Brazil and Canada plus a quantum panel on Sept. 13, 2023

In an August 17, 2023 Canadian Science Policy Centre (CSPC) newsletter (received via email), they’ve announced a panel about science and technology opportunities with a country we don’t usually talk about much in that context (nice to see a broader, not the US and not a European or Commonwealth country, approach being taken),

Canada-Brazil Cooperation and Collaboration in STI [Science, Technology, and Innovation]

This virtual panel aims to discuss the ongoing Science, Technology, and Innovation (STI) cooperation between Brazil and Canada, along with the potential for furthering this relationship. The focus will encompass strategic areas of contact, ongoing projects, and scholarship opportunities. It is pertinent to reflect on the science diplomacy efforts of each country and their reciprocal influence. Additionally, the panel aims to explore how Canada engages with developing countries in terms of STI.

Click the button below to register for the upcoming virtual panel!

Register Here

Date: Sept. 6 [2023] October 4, 2023
Time: 1:00 pm EDT

Here are the speakers (from the CSPC’s Canada-Brazil Cooperation and Collaboration in STI event page),

Fernanda de Negri
Moderator
Director of Studies and Sectoral Policies of Innovation, Regulation and Infrastructure at the Institute for Applied Economic Research (IPEA), Brazil
See Bio

Alejandro Adem
President of Natural Sciences and Engineering Research Council of Canada – NSERC
See Bio

Ambassador Emmanuel Kamarianakis
Canadian Embassy in Canada
See Bio

Ambassador Ademar Seabra da Cruz Jr.
Ministry of Foreign Affairs, Brazil
See Bio

If you haven’t gotten your fill of virtual science policy panels yet, there’s this one on quantum technologies, from the August 17, 2023 Canadian Science Policy Centre (CSPC) newsletter,

Canada’s Quantum Strategy and International Collaboration

Countries are investing heavily in quantum computing and other quantum technologies. As Canada has recently released its Quantum Strategy [Note: There is also report on Quantum Technologies expected from the Canadian Council of Academies, no release date yet], this is an opportunity to foster further international collaborations. Panelists will discuss the opportunities and challenges Canada will be facing and what this could mean for Canada’s leadership in quantum research and the development of quantum technologies.

Click the button below to register for the upcoming virtual panel!

Register Here

Date: Sep 13 [2023]
Time: 1:00 pm EDT

Here’s some information about the panel participants, from the CSPC’s Canada’s Quantum Strategy and International Collaboration event page,

Dr. Sarah Burke
Associate Professor, University of British Columbia
See Bio

Dr. Aimee K. Gunther
Deputy Director, Quantum Sensors Challenge Program, National Research Council Canada
See Bio

Prof. Andrea Damascelli
Scientific Director, Stewart Blusson Quantum Matter Institute | Professor, Physics and Astronomy | Canada Research Chair in the Electronic Structure of Quantum Materials
See Bio

Nick Werstiuk
CEO, Quantum Valley Ideas Lab
See Bio

Eric Miller
Fellow, Canadian Global Affairs Institute
See Bio

Ms. Alexandra Daoud
Moderator
Vice President, Intellectual Property at Anyon Systems
See Bio

Interestingly, the moderator, Alexandra Daoud, is a patent agent.

As for the Council of Canadian Academies, you can find out about the proposed report on Quantum Technologies here.

Unveiling the Neurotechnology Landscape: Scientific Advancements, Innovations and Major Trends—a UNESCO report

Launched on Thursday, July 13, 2023 during UNESCO’s (United Nations Educational, Scientific, and Cultural Organization) “Global dialogue on the ethics of neurotechnology,” is a report tying together the usual measures of national scientific supremacy (number of papers published and number of patents filed) with information on corporate investment in the field. Consequently, “Unveiling the Neurotechnology Landscape: Scientific Advancements, Innovations and Major Trends” by Daniel S. Hain, Roman Jurowetzki, Mariagrazia Squicciarini, and Lihui Xu provides better insight into the international neurotechnology scene than is sometimes found in these kinds of reports. By the way, the report is open access.

Here’s what I mean, from the report‘s short summary,

Since 2013, government investments in this field have exceeded $6 billion. Private investment has also seen significant growth, with annual funding experiencing a 22-fold increase from 2010 to 2020, reaching $7.3 billion and totaling $33.2 billion.

This investment has translated into a 35-fold growth in neuroscience publications between 2000-2021 and 20-fold growth in innovations between 2022-2020, as proxied by patents. However, not all are poised to benefit from such developments, as big divides emerge.

Over 80% of high-impact neuroscience publications are produced by only ten countries, while 70% of countries contributed fewer than 10 such papers over the period considered. Similarly, five countries only hold 87% of IP5 neurotech patents.

This report sheds light on the neurotechnology ecosystem, that is, what is being developed, where and by whom, and informs about how neurotechnology interacts with other technological trajectories, especially Artificial Intelligence [emphasis mine]. [p. 2]

The money aspect is eye-opening even when you already have your suspicions. Also, it’s not entirely unexpected to learn that only ten countries produce over 80% of the high impact neurotech papers and that only five countries hold 87% of the IP5 neurotech patents but it is stunning to see it in context. (If you’re not familiar with the term ‘IP5 patents’, scroll down in this post to the relevant subhead. Hint: It means the patent was filed in one of the top five jurisdictions; I’ll leave you to guess which ones those might be.)

“Since 2013 …” isn’t quite as informative as the authors may have hoped. I wish they had given a time frame for government investments similar to what they did for corporate investments (e.g., 2010 – 2020). Also, is the $6B (likely in USD) government investment cumulative or an estimated annual number? To sum up, I would have appreciated parallel structure and specificity.

Nitpicks aside, there’s some very good material intended for policy makers. On that note, some of the analysis is beyond me. I haven’t used anything even somewhat close to their analytical tools in years and years. This commentaries reflects my interests and a very rapid reading. One last thing, this is being written from a Canadian perspective. With those caveats in mind, here’s some of what I found.

A definition, social issues, country statistics, and more

There’s a definition for neurotechnology and a second mention of artificial intelligence being used in concert with neurotechnology. From the report‘s executive summary,

Neurotechnology consists of devices and procedures used to access, monitor, investigate, assess, manipulate, and/or emulate the structure and function of the neural systems of animals or human beings. It is poised to revolutionize our understanding of the brain and to unlock innovative solutions to treat a wide range of diseases and disorders.

Similarly to Artificial Intelligence (AI), and also due to its convergence with AI, neurotechnology may have profound societal and economic impact, beyond the medical realm. As neurotechnology directly relates to the brain, it triggers ethical considerations about fundamental aspects of human existence, including mental integrity, human dignity, personal identity, freedom of thought, autonomy, and privacy [emphases mine]. Its potential for enhancement purposes and its accessibility further amplifies its prospect social and societal implications.

The recent discussions held at UNESCO’s Executive Board further shows Member States’ desire to address the ethics and governance of neurotechnology through the elaboration of a new standard-setting instrument on the ethics of neurotechnology, to be adopted in 2025. To this end, it is important to explore the neurotechnology landscape, delineate its boundaries, key players, and trends, and shed light on neurotech’s scientific and technological developments. [p. 7]

Here’s how they sourced the data for the report,

The present report addresses such a need for evidence in support of policy making in
relation to neurotechnology by devising and implementing a novel methodology on data from scientific articles and patents:

● We detect topics over time and extract relevant keywords using a transformer-
based language models fine-tuned for scientific text. Publication data for the period
2000-2021 are sourced from the Scopus database and encompass journal articles
and conference proceedings in English. The 2,000 most cited publications per year
are further used in in-depth content analysis.
● Keywords are identified through Named Entity Recognition and used to generate
search queries for conducting a semantic search on patents’ titles and abstracts,
using another language model developed for patent text. This allows us to identify
patents associated with the identified neuroscience publications and their topics.
The patent data used in the present analysis are sourced from the European
Patent Office’s Worldwide Patent Statistical Database (PATSTAT). We consider
IP5 patents filed between 2000-2020 having an English language abstract and
exclude patents solely related to pharmaceuticals.

This approach allows mapping the advancements detailed in scientific literature to the technological applications contained in patent applications, allowing for an analysis of the linkages between science and technology. This almost fully automated novel approach allows repeating the analysis as neurotechnology evolves. [pp. 8-9[

Findings in bullet points,

Key stylized facts are:
● The field of neuroscience has witnessed a remarkable surge in the overall number
of publications since 2000, exhibiting a nearly 35-fold increase over the period
considered, reaching 1.2 million in 2021. The annual number of publications in
neuroscience has nearly tripled since 2000, exceeding 90,000 publications a year
in 2021. This increase became even more pronounced since 2019.
● The United States leads in terms of neuroscience publication output (40%),
followed by the United Kingdom (9%), Germany (7%), China (5%), Canada (4%),
Japan (4%), Italy (4%), France (4%), the Netherlands (3%), and Australia (3%).
These countries account for over 80% of neuroscience publications from 2000 to
2021.
● Big divides emerge, with 70% of countries in the world having less than 10 high-
impact neuroscience publications between 2000 to 2021.
● Specific neurotechnology-related research trends between 2000 and 2021 include:
○ An increase in Brain-Computer Interface (BCI) research around 2010,
maintaining a consistent presence ever since.
○ A significant surge in Epilepsy Detection research in 2017 and 2018,
reflecting the increased use of AI and machine learning in healthcare.
○ Consistent interest in Neuroimaging Analysis, which peaks around 2004,
likely because of its importance in brain activity and language
comprehension studies.
○ While peaking in 2016 and 2017, Deep Brain Stimulation (DBS) remains a
persistent area of research, underlining its potential in treating conditions
like Parkinson’s disease and essential tremor.
● Between 2000 and 2020, the total number of patent applications in this field
increased significantly, experiencing a 20-fold increase from less than 500 to over
12,000. In terms of annual figures, a consistent upward trend in neurotechnology-10
related patent applications emerges, with a notable doubling observed between
2015 and 2020.
• The United States account for nearly half of all worldwide patent applications (47%).
Other major contributors include South Korea (11%), China (10%), Japan (7%),
Germany (7%), and France (5%). These five countries together account for 87%
of IP5 neurotech patents applied between 2000 and 2020.
○ The United States has historically led the field, with a peak around 2010, a
decline towards 2015, and a recovery up to 2020.
○ South Korea emerged as a significant contributor after 1990, overtaking
Germany in the late 2000s to become the second-largest developer of
neurotechnology. By the late 2010s, South Korea’s annual neurotechnology
patent applications approximated those of the United States.
○ China exhibits a sharp increase in neurotechnology patent applications in
the mid-2010s, bringing it on par with the United States in terms of
application numbers.
● The United States ranks highest in both scientific publications and patents,
indicating their strong ability to transform knowledge into marketable inventions.
China, France, and Korea excel in leveraging knowledge to develop patented
innovations. Conversely, countries such as the United Kingdom, Germany, Italy,
Canada, Brazil, and Australia lag behind in effectively translating neurotech
knowledge into patentable innovations.
● In terms of patent quality measured by forward citations, the leading countries are
Germany, US, China, Japan, and Korea.
● A breakdown of patents by technology field reveals that Computer Technology is
the most important field in neurotechnology, exceeding Medical Technology,
Biotechnology, and Pharmaceuticals. The growing importance of algorithmic
applications, including neural computing techniques, also emerges by looking at
the increase in patent applications in these fields between 2015-2020. Compared
to the reference year, computer technologies-related patents in neurotech
increased by 355% and by 92% in medical technology.
● An analysis of the specialization patterns of the top-5 countries developing
neurotechnologies reveals that Germany has been specializing in chemistry-
related technology fields, whereas Asian countries, particularly South Korea and
China, focus on computer science and electrical engineering-related fields. The
United States exhibits a balanced configuration with specializations in both
chemistry and computer science-related fields.
● The entities – i.e. both companies and other institutions – leading worldwide
innovation in the neurotech space are: IBM (126 IP5 patents, US), Ping An
Technology (105 IP5 patents, CH), Fujitsu (78 IP5 patents, JP), Microsoft (76 IP511
patents, US)1, Samsung (72 IP5 patents, KR), Sony (69 IP5 patents JP) and Intel
(64 IP5 patents US)

This report further proposes a pioneering taxonomy of neurotechnologies based on International Patent Classification (IPC) codes.

• 67 distinct patent clusters in neurotechnology are identified, which mirror the diverse research and development landscape of the field. The 20 most prominent neurotechnology groups, particularly in areas like multimodal neuromodulation, seizure prediction, neuromorphic computing [emphasis mine], and brain-computer interfaces, point to potential strategic areas for research and commercialization.
• The variety of patent clusters identified mirrors the breadth of neurotechnology’s potential applications, from medical imaging and limb rehabilitation to sleep optimization and assistive exoskeletons.
• The development of a baseline IPC-based taxonomy for neurotechnology offers a structured framework that enriches our understanding of this technological space, and can facilitate research, development and analysis. The identified key groups mirror the interdisciplinary nature of neurotechnology and underscores the potential impact of neurotechnology, not only in healthcare but also in areas like information technology and biomaterials, with non-negligible effects over societies and economies.

1 If we consider Microsoft Technology Licensing LLM and Microsoft Corporation as being under the same umbrella, Microsoft leads worldwide developments with 127 IP5 patents. Similarly, if we were to consider that Siemens AG and Siemens Healthcare GmbH belong to the same conglomerate, Siemens would appear much higher in the ranking, in third position, with 84 IP5 patents. The distribution of intellectual property assets across companies belonging to the same conglomerate is frequent and mirrors strategic as well as operational needs and features, among others. [pp. 9-11]

Surprises and comments

Interesting and helpful to learn that “neurotechnology interacts with other technological trajectories, especially Artificial Intelligence;” this has changed and improved my understanding of neurotechnology.

It was unexpected to find Canada in the top ten countries producing neuroscience papers. However, finding out that the country lags in translating its ‘neuro’ knowledge into patentable innovation is not entirely a surprise.

It can’t be an accident that countries with major ‘electronics and computing’ companies lead in patents. These companies do have researchers but they also buy startups to acquire patents. They (and ‘patent trolls’) will also file patents preemptively. For the patent trolls, it’s a moneymaking proposition and for the large companies, it’s a way of protecting their own interests and/or (I imagine) forcing a sale.

The mention of neuromorphic (brainlike) computing in the taxonomy section was surprising and puzzling. Up to this point, I’ve thought of neuromorphic computing as a kind of alternative or addition to standard computing but the authors have blurred the lines as per UNESCO’s definition of neurotechnology (specifically, “… emulate the structure and function of the neural systems of animals or human beings”) . Again, this report is broadening my understanding of neurotechnology. Of course, it required two instances before I quite grasped it, the definition and the taxonomy.

What’s puzzling is that neuromorphic engineering, a broader term that includes neuromorphic computing, isn’t used or mentioned. (For an explanation of the terms neuromorphic computing and neuromorphic engineering, there’s my June 23, 2023 posting, “Neuromorphic engineering: an overview.” )

The report

I won’t have time for everything. Here are some of the highlights from my admittedly personal perspective.

It’s not only about curing disease

From the report,

Neurotechnology’s applications however extend well beyond medicine [emphasis mine], and span from research, to education, to the workplace, and even people’s everyday life. Neurotechnology-based solutions may enhance learning and skill acquisition and boost focus through brain stimulation techniques. For instance, early research finds that brain- zapping caps appear to boost memory for at least one month (Berkeley, 2022). This could one day be used at home to enhance memory functions [emphasis mine]. They can further enable new ways to interact with the many digital devices we use in everyday life, transforming the way we work, live and interact. One example is the Sound Awareness wristband developed by a Stanford team (Neosensory, 2022) which enables individuals to “hear” by converting sound into tactile feedback, so that sound impaired individuals can perceive spoken words through their skin. Takagi and Nishimoto (2023) analyzed the brain scans taken through Magnetic Resonance Imaging (MRI) as individuals were shown thousands of images. They then trained a generative AI tool called Stable Diffusion2 on the brain scan data of the study’s participants, thus creating images that roughly corresponded to the real images shown. While this does not correspond to reading the mind of people, at least not yet, and some limitations of the study have been highlighted (Parshall, 2023), it nevertheless represents an important step towards developing the capability to interface human thoughts with computers [emphasis mine], via brain data interpretation.

While the above examples may sound somewhat like science fiction, the recent uptake of generative Artificial Intelligence applications and of large language models such as ChatGPT or Bard, demonstrates that the seemingly impossible can quickly become an everyday reality. At present, anyone can purchase online electroencephalogram (EEG) devices for a few hundred dollars [emphasis mine], to measure the electrical activity of their brain for meditation, gaming, or other purposes. [pp. 14-15]

This is very impressive achievement. Some of the research cited was published earlier this year (2023). The extraordinary speed is a testament to the efforts by the authors and their teams. It’s also a testament to how quickly the field is moving.

I’m glad to see the mention of and focus on consumer neurotechnology. (While the authors don’t speculate, I am free to do so.) Consumer neurotechnology could be viewed as one of the steps toward normalizing a cyborg future for all of us. Yes, we have books, television programmes, movies, and video games, which all normalize the idea but the people depicted have been severely injured and require the augmentation. With consumer neurotechnology, you have easily accessible devices being used to enhance people who aren’t injured, they just want to be ‘better’.

This phrase seemed particularly striking “… an important step towards developing the capability to interface human thoughts with computers” in light of some claims made by the Australian military in my June 13, 2023 posting “Mind-controlled robots based on graphene: an Australian research story.” (My posting has an embedded video demonstrating the Brain Robotic Interface (BRI) in action. Also, see the paragraph below the video for my ‘measured’ response.)

There’s no mention of the military in the report which seems more like a deliberate rather than inadvertent omission given the importance of military innovation where technology is concerned.

This section gives a good overview of government initiatives (in the report it’s followed by a table of the programmes),

Thanks to the promises it holds, neurotechnology has garnered significant attention from both governments and the private sector and is considered by many as an investment priority. According to the International Brain Initiative (IBI), brain research funding has become increasingly important over the past ten years, leading to a rise in large-scale state-led programs aimed at advancing brain intervention technologies(International Brain Initiative, 2021). Since 2013, initiatives such as the United States’ Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative and the European Union’s Human Brain Project (HBP), as well as major national initiatives in China, Japan and South Korea have been launched with significant funding support from the respective governments. The Canadian Brain Research Strategy, initially operated as a multi- stakeholder coalition on brain research, is also actively seeking funding support from the government to transform itself into a national research initiative (Canadian Brain Research Strategy, 2022). A similar proposal is also seen in the case of the Australian Brain Alliance, calling for the establishment of an Australian Brain Initiative (Australian Academy of Science, n.d.). [pp. 15-16]

Privacy

There are some concerns such as these,

Beyond the medical realm, research suggests that emotional responses of consumers
related to preferences and risks can be concurrently tracked by neurotechnology, such
as neuroimaging and that neural data can better predict market-level outcomes than
traditional behavioral data (Karmarkar and Yoon, 2016). As such, neural data is
increasingly sought after in the consumer market for purposes such as digital
phenotyping4, neurogaming 5,and neuromarketing6 (UNESCO, 2021). This surge in demand gives rise to risks like hacking, unauthorized data reuse, extraction of privacy-sensitive information, digital surveillance, criminal exploitation of data, and other forms of abuse. These risks prompt the question of whether neural data needs distinct definition and safeguarding measures.

These issues are particularly relevant today as a wide range of electroencephalogram (EEG) headsets that can be used at home are now available in consumer markets for purposes that range from meditation assistance to controlling electronic devices through the mind. Imagine an individual is using one of these devices to play a neurofeedback game, which records the person’s brain waves during the game. Without the person being aware, the system can also identify the patterns associated with an undiagnosed mental health condition, such as anxiety. If the game company sells this data to third parties, e.g. health insurance providers, this may lead to an increase of insurance fees based on undisclosed information. This hypothetical situation would represent a clear violation of mental privacy and of unethical use of neural data.

Another example is in the field of advertising, where companies are increasingly interested in using neuroimaging to better understand consumers’ responses to their products or advertisements, a practice known as neuromarketing. For instance, a company might use neural data to determine which advertisements elicit the most positive emotional responses in consumers. While this can help companies improve their marketing strategies, it raises significant concerns about mental privacy. Questions arise in relation to consumers being aware or not that their neural data is being used, and in the extent to which this can lead to manipulative advertising practices that unfairly exploit unconscious preferences. Such potential abuses underscore the need for explicit consent and rigorous data protection measures in the use of neurotechnology for neuromarketing purposes. [pp. 21-22]

Legalities

Some countries already have laws and regulations regarding neurotechnology data,

At the national level, only a few countries have enacted laws and regulations to protect mental integrity or have included neuro-data in personal data protection laws (UNESCO, University of Milan-Bicocca (Italy) and State University of New York – Downstate Health Sciences University, 2023). Examples are the constitutional reform undertaken by Chile (Republic of Chile, 2021), the Charter for the responsible development of neurotechnologies of the Government of France (Government of France, 2022), and the Digital Rights Charter of the Government of Spain (Government of Spain, 2021). They propose different approaches to the regulation and protection of human rights in relation to neurotechnology. Countries such as the UK are also examining under which circumstances neural data may be considered as a special category of data under the general data protection framework (i.e. UK’s GDPR) (UK’s Information Commissioner’s Office, 2023) [p. 24]

As you can see, these are recent laws. There doesn’t seem to be any attempt here in Canada even though there is an act being reviewed in Parliament that could conceivably include neural data. This is from my May 1, 2023 posting,

Bill C-27 (Digital Charter Implementation Act, 2022) is what I believe is called an omnibus bill as it includes three different pieces of proposed legislation (the Consumer Privacy Protection Act [CPPA], the Artificial Intelligence and Data Act [AIDA], and the Personal Information and Data Protection Tribunal Act [PIDPTA]). [emphasis added July 11, 2023] You can read the Innovation, Science and Economic Development (ISED) Canada summary here or a detailed series of descriptions of the act here on the ISED’s Canada’s Digital Charter webpage.

My focus at the time was artificial intelligence and, now, after reading this UNESCO report and briefly looking at the Innovation, Science and Economic Development (ISED) Canada summary and a detailed series of descriptions of the act on ISED’s Canada’s Digital Charter webpage, I don’t see anything that specifies neural data but it’s not excluded either.

IP5 patents

Here’s the explanation (the footnote is included at the end of the excerpt),

IP5 patents represent a subset of overall patents filed worldwide, which have the
characteristic of having been filed in at least one top intellectual property offices (IPO)
worldwide (the so called IP5, namely the Chinese National Intellectual Property
Administration, CNIPA (formerly SIPO); the European Patent Office, EPO; the Japan
Patent Office, JPO; the Korean Intellectual Property Office, KIPO; and the United States
Patent and Trademark Office, USPTO) as well as another country, which may or may not be an IP5. This signals their potential applicability worldwide, as their inventiveness and industrial viability have been validated by at least two leading IPOs. This gives these patents a sort of “quality” check, also since patenting inventions is costly and if applicants try to protect the same invention in several parts of the world, this normally mirrors that the applicant has expectations about their importance and expected value. If we were to conduct the same analysis using information about individually considered patent applied worldwide, i.e. without filtering for quality nor considering patent families, we would risk conducting a biased analysis based on duplicated data. Also, as patentability standards vary across countries and IPOs, and what matters for patentability is the existence (or not) of prior art in the IPO considered, we would risk mixing real innovations with patents related to catching up phenomena in countries that are not at the forefront of the technology considered.

9 The five IP offices (IP5) is a forum of the five largest intellectual property offices in the world that was set up to improve the efficiency of the examination process for patents worldwide. The IP5 Offices together handle about 80% of the world’s patent applications, and 95% of all work carried out under the Patent Cooperation Treaty (PCT), see http://www.fiveipoffices.org. (Dernis et al., 2015) [p. 31]

AI assistance on this report

As noted earlier I have next to no experience with the analytical tools having not attempted this kind of work in several years. Here’s an example of what they were doing,

We utilize a combination of text embeddings based on Bidirectional Encoder
Representations from Transformer (BERT), dimensionality reduction, and hierarchical
clustering inspired by the BERTopic methodology 12 to identify latent themes within
research literature. Latent themes or topics in the context of topic modeling represent
clusters of words that frequently appear together within a collection of documents (Blei, 2012). These groupings are not explicitly labeled but are inferred through computational analysis examining patterns in word usage. These themes are ‘hidden’ within the text, only to be revealed through this analysis. …

We further utilize OpenAI’s GPT-4 model to enrich our understanding of topics’ keywords and to generate topic labels (OpenAI, 2023), thus supplementing expert review of the broad interdisciplinary corpus. Recently, GPT-4 has shown impressive results in medical contexts across various evaluations (Nori et al., 2023), making it a useful tool to enhance the information obtained from prior analysis stages, and to complement them. The automated process enhances the evaluation workflow, effectively emphasizing neuroscience themes pertinent to potential neurotechnology patents. Notwithstanding existing concerns about hallucinations (Lee, Bubeck and Petro, 2023) and errors in generative AI models, this methodology employs the GPT-4 model for summarization and interpretation tasks, which significantly mitigates the likelihood of hallucinations. Since the model is constrained to the context provided by the keyword collections, it limits the potential for fabricating information outside of the specified boundaries, thereby enhancing the accuracy and reliability of the output. [pp. 33-34]

I couldn’t resist adding the ChatGPT paragraph given all of the recent hoopla about it.

Multimodal neuromodulation and neuromorphic computing patents

I think this gives a pretty good indication of the activity on the patent front,

The largest, coherent topic, termed “multimodal neuromodulation,” comprises 535
patents detailing methodologies for deep or superficial brain stimulation designed to
address neurological and psychiatric ailments. These patented technologies interact with various points in neural circuits to induce either Long-Term Potentiation (LTP) or Long-Term Depression (LTD), offering treatment for conditions such as obsession, compulsion, anxiety, depression, Parkinson’s disease, and other movement disorders. The modalities encompass implanted deep-brain stimulators (DBS), Transcranial Magnetic Stimulation (TMS), and transcranial Direct Current Stimulation (tDCS). Among the most representative documents for this cluster are patents with titles: Electrical stimulation of structures within the brain or Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson’s disease and or other movement disorders. [p.65]

Given my longstanding interest in memristors, which (I believe) have to a large extent helped to stimulate research into neuromorphic computing, this had to be included. Then, there was the brain-computer interfaces cluster,

A cluster identified as “Neuromorphic Computing” consists of 366 patents primarily
focused on devices designed to mimic human neural networks for efficient and adaptable computation. The principal elements of these inventions are resistive memory cells and artificial synapses. They exhibit properties similar to the neurons and synapses in biological brains, thus granting these devices the ability to learn and modulate responses based on rewards, akin to the adaptive cognitive capabilities of the human brain.

The primary technology classes associated with these patents fall under specific IPC
codes, representing the fields of neural network models, analog computers, and static
storage structures. Essentially, these classifications correspond to technologies that are key to the construction of computers and exhibit cognitive functions similar to human brain processes.

Examples for this cluster include neuromorphic processing devices that leverage
variations in resistance to store and process information, artificial synapses exhibiting
spike-timing dependent plasticity, and systems that allow event-driven learning and
reward modulation within neuromorphic computers.

In relation to neurotechnology as a whole, the “neuromorphic computing” cluster holds significant importance. It embodies the fusion of neuroscience and technology, thereby laying the basis for the development of adaptive and cognitive computational systems. Understanding this specific cluster provides a valuable insight into the progressing domain of neurotechnology, promising potential advancements across diverse fields, including artificial intelligence and healthcare.

The “Brain-Computer Interfaces” cluster, consisting of 146 patents, embodies a key aspect of neurotechnology that focuses on improving the interface between the brain and external devices. The technology classification codes associated with these patents primarily refer to methods or devices for treatment or protection of eyes and ears, devices for introducing media into, or onto, the body, and electric communication techniques, which are foundational elements of brain-computer interface (BCI) technologies.

Key patents within this cluster include a brain-computer interface apparatus adaptable to use environment and method of operating thereof, a double closed circuit brain-machine interface system, and an apparatus and method of brain-computer interface for device controlling based on brain signal. These inventions mainly revolve around the concept of using brain signals to control external devices, such as robotic arms, and improving the classification performance of these interfaces, even after long periods of non-use.

The inventions described in these patents improve the accuracy of device control, maintain performance over time, and accommodate multiple commands, thus significantly enhancing the functionality of BCIs.

Other identified technologies include systems for medical image analysis, limb rehabilitation, tinnitus treatment, sleep optimization, assistive exoskeletons, and advanced imaging techniques, among others. [pp. 66-67]

Having sections on neuromorphic computing and brain-computer interface patents in immediate proximity led to more speculation on my part. Imagine how much easier it would be to initiate a BCI connection if it’s powered with a neuromorphic (brainlike) computer/device. [ETA July 21, 2023: Following on from that thought, it might be more than just easier to initiate a BCI connection. Could a brainlike computer become part of your brain? Why not? it’s been successfully argued that a robotic wheelchair was part of someone’s body, see my January 30, 2013 posting and scroll down about 40% of the way.)]

Neurotech policy debates

The report concludes with this,

Neurotechnology is a complex and rapidly evolving technological paradigm whose
trajectories have the power to shape people’s identity, autonomy, privacy, sentiments,
behaviors and overall well-being, i.e. the very essence of what it means to be human.

Designing and implementing careful and effective norms and regulations ensuring that neurotechnology is developed and deployed in an ethical manner, for the good of
individuals and for society as a whole, call for a careful identification and characterization of the issues at stake. This entails shedding light on the whole neurotechnology ecosystem, that is what is being developed, where and by whom, and also understanding how neurotechnology interacts with other developments and technological trajectories, especially AI. Failing to do so may result in ineffective (at best) or distorted policies and policy decisions, which may harm human rights and human dignity.

Addressing the need for evidence in support of policy making, the present report offers first time robust data and analysis shedding light on the neurotechnology landscape worldwide. To this end, its proposes and implements an innovative approach that leverages artificial intelligence and deep learning on data from scientific publications and paten[t]s to identify scientific and technological developments in the neurotech space. The methodology proposed represents a scientific advance in itself, as it constitutes a quasi- automated replicable strategy for the detection and documentation of neurotechnology- related breakthroughs in science and innovation, to be repeated over time to account for the evolution of the sector. Leveraging this approach, the report further proposes an IPC-based taxonomy for neurotechnology which allows for a structured framework to the exploration of neurotechnology, to enable future research, development and analysis. The innovative methodology proposed is very flexible and can in fact be leveraged to investigate different emerging technologies, as they arise.

In terms of technological trajectories, we uncover a shift in the neurotechnology industry, with greater emphasis being put on computer and medical technologies in recent years, compared to traditionally dominant trajectories related to biotechnology and pharmaceuticals. This shift warrants close attention from policymakers, and calls for attention in relation to the latest (converging) developments in the field, especially AI and related methods and applications and neurotechnology.

This is all the more important and the observed growth and specialization patterns are unfolding in the context of regulatory environments that, generally, are either not existent or not fit for purpose. Given the sheer implications and impact of neurotechnology on the very essence of human beings, this lack of regulation poses key challenges related to the possible infringement of mental integrity, human dignity, personal identity, privacy, freedom of thought, and autonomy, among others. Furthermore, issues surrounding accessibility and the potential for neurotech enhancement applications triggers significant concerns, with far-reaching implications for individuals and societies. [pp. 72-73]

Last words about the report

Informative, readable, and thought-provoking. And, it helped broaden my understanding of neurotechnology.

Future endeavours?

I’m hopeful that one of these days one of these groups (UNESCO, Canadian Science Policy Centre, or ???) will tackle the issue of business bankruptcy in the neurotechnology sector. It has already occurred as noted in my ““Going blind when your neural implant company flirts with bankruptcy [long read]” April 5, 2022 posting. That story opens with a woman going blind in a New York subway when her neural implant fails. It’s how she found out the company, which supplied her implant was going out of business.

In my July 7, 2023 posting about the UNESCO July 2023 dialogue on neurotechnology, I’ve included information on Neuralink (one of Elon Musk’s companies) and its approval (despite some investigations) by the US Food and Drug Administration to start human clinical trials. Scroll down about 75% of the way to the “Food for thought” subhead where you will find stories about allegations made against Neuralink.

The end

If you want to know more about the field, the report offers a seven-page bibliography and there’s a lot of material here where you can start with this December 3, 2019 posting “Neural and technological inequalities” which features an article mentioning a discussion between two scientists. Surprisingly (to me), the source article is in Fast Company (a leading progressive business media brand), according to their tagline)..

I have two categories you may want to check: Human Enhancement and Neuromorphic Engineering. There are also a number of tags: neuromorphic computing, machine/flesh, brainlike computing, cyborgs, neural implants, neuroprosthetics, memristors, and more.

Should you have any observations or corrections, please feel free to leave them in the Comments section of this posting.