Tag Archives: Health Canada

Virtual panel discussion: Canadian Strategies for Responsible Neurotechnology Innovation on May 16, 2023

The Canadian Science Policy Centre (CSPC) sent a May 11, 2023 notice (via email) about an upcoming event but first, congratulations (Bravo!) are in order,

The Science Meets Parliament [SMP] Program 2023 is now complete and was a huge success. 43 Delegates from across Canada met with 62 Parliamentarians from across the political spectrum on the Hill on May 1-2, 2023.

The SMP Program is championed by CSPC and Canada’s Chief Science Advisor, Dr. Mona Nemer [through the Office of the Chief Science Advisor {OCSA}].

This Program would not have been possible without the generous support of our sponsors: The Royal Military College of Canada, The Stem Cell Network, and the University of British Columbia.

There are 443 seats in Canada’s Parliament with 338 in the House of Commons and 105 in the Senate and 2023 is the third time the SMP programme has been offered. (It was previously held in 2018 and 2022 according to the SMP program page.)

The Canadian programme is relatively new compared to Australia where they’ve had a Science Meets Parliament programme since 1999 (according to a March 20, 2017 essay by Ken Baldwin, Director of Energy Change Institute at Australian National University for The Conversation). The Scottish have had a Science and the Parliament programme since 2000 (according to this 2022 event notice on the Royal Society of Chemistry’s website).

By comparison to the other two, the Canadian programme is a toddler. (We tend not to recognize walking for the major achievement it is.) So, bravo to the CSPC and OCSA on getting 62 Parliamentarians to make time in their schedules to meet a scientist.

Responsible neurotechnology innovation?

From the Canadian Strategies for Responsible Neurotechnology Innovation event page on the CSPC website,

Advances in neurotechnology are redefining the possibilities of improving neurologic health and mental wellbeing, but related ethical, legal, and societal concerns such as privacy of brain data, manipulation of personal autonomy and agency, and non-medical and dual uses are increasingly pressing concerns [emphasis mine]. In this regard, neurotechnology presents challenges not only to Canada’s federal and provincial health care systems, but to existing laws and regulations that govern responsible innovation. In December 2019, just before the pandemic, the OECD [Organisation for Economic Cooperation and Development] Council adopted a Recommendation on Responsible Innovation in Neurotechnology. It is now urging that member states develop right-fit implementation strategies.

What should these strategies look like for Canada? We will propose and discuss opportunities that balance and leverage different professional and governance approaches towards the goal of achieving responsible innovation for the current state of the art, science, engineering, and policy, and in anticipation of the rapid and vast capabilities expected for neurotechnology in the future by and for this country.

Link to the full OECD Recommendation on Responsible Innovation in Neurotechnology

Date: May 16 [2023]

Time: 12:00 pm – 1:30 pm EDT

Event Category: Virtual Session [on Zoom]

Registration Page: https://us02web.zoom.us/webinar/register/WN_-g8d1qubRhumPSCQi6WUtA

The panelists are:

Dr. Graeme Moffat
Neurotechnology entrepreneur & Senior Fellow, Munk School of Global Affairs & Public Policy [University of Toronto]

Dr. Graeme Moffat is a co-founder and scientist with System2 Neurotechnology. He previously was Chief Scientist and VP of Regulatory Affairs at Interaxon, Chief Scientist with ScienceScape (later Chan-Zuckerberg Meta), and a research engineer at Neurelec (a division of Oticon Medical). He served as Managing Editor of Frontiers in Neuroscience, the largest open access scholarly journal series in the field of neuroscience. Dr. Moffat is a Senior Fellow at the Munk School of Global Affairs and Public Policy and an advisor to the OECD’s neurotechnology policy initiative.

Professor Jennifer Chandler
Professor of Law at the Centre for Health Law, Policy and Ethics, University of Ottawa

Jennifer Chandler is Professor of Law at the Centre for Health Law, Policy and Ethics, University of Ottawa. She leads the “Neuroethics Law and Society” Research Pillar for the Brain Mind Research Institute and sits on its Scientific Advisory Council. Her research focuses on the ethical, legal and policy issues in brain sciences and the law. She teaches mental health law and neuroethics, tort law, and medico-legal issues. She is a member of the advisory board for CIHR’s Institute for Neurosciences, Mental Health and Addiction (IMNA) and serves on international editorial boards in the field of law, ethics and neuroscience, including Neuroethics, the Springer Book Series Advances in Neuroethics, and the Palgrave-MacMillan Book Series Law, Neuroscience and Human Behavior. She has published widely in legal, bioethical and health sciences journals and is the co-editor of the book Law and Mind: Mental Health Law and Policy in Canada (2016). Dr. Chandler brings a unique perspective to this panel as her research focuses on the ethical, legal and policy issues at the intersection of the brain sciences and the law. She is active in Canadian neuroscience research funding policy, and regularly contributes to Canadian governmental policy on contentious matters of biomedicine.

Ian Burkhart
Neurotech Advocate and Founder of BCI [brain-computer interface] Pioneers Coalition

Ian is a C5 tetraplegic [also known as quadriplegic] from a diving accident in 2010. He participated in a ground-breaking clinical trial using a brain-computer interface to control muscle stimulation. He is the founder of the BCI Pioneers Coalition, which works to establish ethics, guidelines and best practices for future patients, clinicians, and commercial entities engaging with BCI research. Ian serves as Vice President of the North American Spinal Cord Injury Consortium and chairs their project review committee. He has also worked with Unite2Fight Paralysis to advocate for $9 million of SCI research in his home state of Ohio. Ian has been a Reeve peer mentor since 2015 and helps lead two local SCI networking groups. As the president of the Ian Burkhart Foundation, he raises funds for accessible equipment for the independence of others with SCI. Ian is also a full-time consultant working with multiple medical device companies.

Andrew Atkinson
Manager, Emerging Science Policy, Health Canada

Andrew Atkinson is the Manager of the Emerging Sciences Policy Unit under the Strategic Policy Branch of Health Canada. He oversees coordination of science policy issues across the various regulatory and research programs under the mandate of Health Canada. Prior to Health Canada, he was a manager under Environment Canada’s CEPA new chemicals program, where he oversaw chemical and nanomaterial risk assessments, and the development of risk assessment methodologies. In parallel to domestic work, he has been actively engaged in ISO [International Organization for Standardization and OECD nanotechnology efforts.

Andrew is currently a member of the Canadian delegation to the OECD Working Party on Biotechnology, Nanotechnology and Converging Technologies (BNCT). BNCT aims to contribute original policy analysis on emerging science and technologies, such as gene editing and neurotechnology, including messaging to the global community, convening key stakeholders in the field, and making ground-breaking proposals to policy makers.

Professor Judy Illes
Professor, Division of Neurology, Department of Medicine, Faculty of Medicine, UBC [University of British Columbia]

Dr. Illes is Professor of Neurology and Distinguished Scholar in Neuroethics at the University of British Columbia. She is the Director of Neuroethics Canada, and among her many leadership positions in Canada, she is Vice Chair of the Canadian Institutes of Health Research (CIHR) Advisory Board of the Institute on Neuroscience, Mental Health and Addiction (INMHA), and chair of the International Brain Initiative (www.internationalbraininitiative.org; www.canadianbrain.ca), Director at Large of the Canadian Academy of Health Sciences, and a member of the Board of Directors of the Council of Canadian Academies.

Dr. Illes is a world-renown expert whose research, teaching and outreach are devoted to ethical, legal, social and policy challenges at the intersection of the brain sciences and biomedical ethics. She has made ground breaking contributions to neuroethical thinking for neuroscience discovery and clinical translation across the life span, including in entrepreneurship and in the commercialization of health care. Dr. Illes has a unique and comprehensive overview of the field of neurotechnology and the relevant sectors in Canada.

One concern I don’t see mentioned is bankruptcy (in other words, what happens if the company that made your neural implant goes bankrupt?) either in the panel description or in the OECD recommendation. My April 5, 2022 posting “Going blind when your neural implant company flirts with bankruptcy (long read)” explored that topic and while many of the excerpted materials present a US perspective, it’s easy to see how it could also apply in Canada and elsewhere.

For those of us on the West Coast, this session starts at 9 am. Enjoy!

*June 20, 2023: This sentence changed (We tend not to recognize that walking for the major achievement it is.) to We tend not to recognize walking for the major achievement it is.

Health Canada advisory: Face masks that contain graphene may pose health risks

Since COVID-19, we’ve been advised to wear face masks. It seems some of them may not be as safe as we assumed. First, the Health Canada advisory that was issued today, April 2, 2021 and then excerpts from an in-depth posting by Dr. Andrew Maynard (associate dean in the Arizona State University College of Global Futures) about the advisory and the use of graphene in masks.

From the Health Canada Recalls & alerts: Face masks that contain graphene may pose health risks webpage,

Summary

  • Product: Face masks labelled to contain graphene or biomass graphene.
  • Issue: There is a potential that wearers could inhale graphene particles from some masks, which may pose health risks.
  • What to do: Do not use these face masks. Report any health product adverse events or complaints to Health Canada.

Issue

Health Canada is advising Canadians not to use face masks that contain graphene because there is a potential that they could inhale graphene particles, which may pose health risks.

Graphene is a novel nanomaterial (materials made of tiny particles) reported to have antiviral and antibacterial properties. Health Canada conducted a preliminary scientific assessment after being made aware that masks containing graphene have been sold with COVID-19 claims and used by adults and children in schools and daycares. Health Canada believes they may also have been distributed for use in health care settings.

Health Canada’s preliminary assessment of available research identified that inhaled graphene particles had some potential to cause early lung toxicity in animals. However, the potential for people to inhale graphene particles from face masks and the related health risks are not yet known, and may vary based on mask design. The health risk to people of any age is not clear. Variables, such as the amount and duration of exposure, and the type and characteristics of the graphene material used, all affect the potential to inhale particles and the associated health risks. Health Canada has requested data from mask manufacturers to assess the potential health risks related to their masks that contain graphene.

Until the Department completes a thorough scientific assessment and has established the safety and effectiveness of graphene-containing face masks, it is taking the precautionary approach of removing them from the market while continuing to gather and assess information. Health Canada has directed all known distributors, importers and manufacturers to stop selling and to recall the affected products. Additionally, Health Canada has written to provinces and territories advising them to stop distribution and use of masks containing graphene. The Department will continue to take appropriate action to stop the import and sale of graphene face masks.

Products affected

Face masks labelled as containing graphene or biomass graphene.

What you should do

  • Do not use face masks labelled to contain graphene or biomass graphene.
  • Consult your health care provider if you have used graphene face masks and have health concerns, such as new or unexplained shortness of breath, discomfort or difficulty breathing.
  • Report any health product adverse events or complaints regarding graphene face masks to Health Canada.

Dr. Andrew Maynard’s Edge of Innovation series features a March 26, 2021 posting about the use of graphene in masks (Note: Links have been removed),

Face masks should protect you, not place you in greater danger. However, last Friday Radio Canada revealed that residents of Quebec and Ottawa were being advised not to use specific types of graphene-containing masks as they could potentially be harmful.

The offending material in the masks is graphene — a form of carbon that consists of nanoscopically thin flakes of hexagonally-arranged carbon atoms. It’s a material that has a number of potentially beneficial properties, including the ability to kill bacteria and viruses when they’re exposed to it.

Yet despite its many potential uses, the scientific jury is still out when it comes to how safe the material is.

As with all materials, the potential health risks associated with graphene depend on whether it can get into the body, where it goes if it can, what it does when it gets there, and how much of it is needed to cause enough damage to be of concern.

Unfortunately, even though these are pretty basic questions, there aren’t many answers forthcoming when it comes to the substance’s use in face masks.

Early concerns around graphene were sparked by previous research on another form of carbon — carbon nanotubes. It turns out that some forms of these fiber-like materials can cause serious harm if inhaled. And following on from research here, a natural next-question to ask is whether carbon nanotubes’ close cousin graphene comes with similar concerns.

Because graphene lacks many of the physical and chemical aspects of carbon nanotubes that make them harmful (such as being long, thin, and hard for the body to get rid of), the indications are that the material is safer than its nanotube cousins. But safer doesn’t mean safe. And current research indicates that this is not a material that should be used where it could potentially be inhaled, without a good amount of safety testing first.

[downloaded from https://medium.com/edge-of-innovation/how-safe-are-graphene-based-face-masks-b88740547e8c] Original source: Wikimedia

When it comes to inhaling graphene, the current state of the science indicates that if the material can get into the lower parts of the lungs (the respirable or alveolar region) it can lead to an inflammatory response at high enough concentrations.

There is some evidence that adverse responses are relatively short-lived, and that graphene particles can be broken down and disposed of by the lungs’ defenses.

This is good news as it means that there are less likely to be long-term health impacts from inhaling the material.

There’s also evidence that graphene, unlike some forms of thin, straight carbon nanotubes, does not migrate to the outside layers of the lungs where it could potentially do a lot more damage.

Again, this is encouraging as it suggests that graphene is unlikely to lead to serious long-term health impacts like mesothelioma.

However, research also shows that this is not a benign material. Despite being made of carbon — and it’s tempting to think of carbon as being safe, just because we’re familiar with it — there is some evidence that the jagged edges of some graphene particles can harm cells, leading to local damage as the body responds to any damage the material causes.

There are also concerns, although they are less well explored in the literature, that some forms of graphene may be carriers for nanometer-sized metal particles that can be quite destructive in the lungs. This is certainly the case with some carbon nanotubes, as the metallic catalyst particles used to manufacture them become embedded in the material, and contribute to its toxicity.

The long and short of this is that, while there are still plenty of gaps in our knowledge around how much graphene it’s safe to inhale, inhaling small graphene particles probably isn’t a great idea unless there’s been comprehensive testing to show otherwise.

And this brings us to graphene-containing face masks.

….

Here, it’s important to stress that we don’t yet know if graphene particles are being released and, if they are, whether they are being released in sufficient quantities to cause health effects. And there are indications that, if there are health risks, these may be relatively short-term — simply because graphene particles may be effectively degraded by the lungs’ defenses.

At the same time, it seems highly irresponsible to include a material with unknown inhalation risks in a product that is intimately associated with inhalation. Especially when there are a growing number of face masks available that claim to use graphene.

… There are millions of graphene face masks and respirators being sold and used around the world. And while the unfolding news focuses on Quebec and one particular type of face mask, this is casting uncertainty over the safety of any graphene-containing masks that are being sold.

And this uncertainty will persist until manufacturers and regulators provide data indicating that they have tested the products for the release and subsequent inhalation of fine graphene particles, and shown the risks to be negligible.

I strongly recommend reading, in its entirety , Dr. Maynard’s March 26, 2021 posting, Which he has updated twice since first posting the story.

In short. you may want to hold off before buying a mask with graphene until there’s more data about safety.

Increased food security with hexanal for younger looking, fresher tasting fruits and vegetables

Also known as an anti-aging agent for your fruit and vegetables, hexanal is an environmentally friendly chemical, which is found naturally. Research has led to a synthesized nanotechnology-enabled product now being commercialized. I’ve been following the story off and on since 2012 (see my ‘India, Sri Lanka, and Canada team up for nanotechnology-enabled food packaging‘ posting). I last wrote about the project in a December 29, 2015 posting.

For some reason, hexanal hit the news hard in 2019 having been preceded by some interest in 2018. What follows is an update and a timeline of sorts.

January 2019: More funding

A January 24,2019 essay (also published on the University of Guelph website on January 29, 2019) by Jayasankar Subramanian and Elizabeth Finnis, both are lead researchers on the the project and professors at the University of Guelph (Canada), provides an overview and an update of the hexanal project (Note: Links have been removed) ,

Fruits like mangoes, bananas, papayas and limes are shipped long distances before they get to your table. Many fruits are delicate, and there may be a long period of time that elapses between when the fruit is picked and its arrival in grocery stores and other markets. They’re often picked before they’re truly ripe in order to increase their shelf life.

Even so, globally, up to 40 per cent of all picked fruit can be lost and this represents billions of dollars. But what if we had the technology to delay fruit’s natural degradation process? This is where hexanal can make a difference.

Fruits like mangoes, bananas, papayas and limes are shipped long distances before they get to your table. Many fruits are delicate, and there may be a long period of time that elapses between when the fruit is picked and its arrival in grocery stores and other markets. They’re often picked before they’re truly ripe in order to increase their shelf life.

Even so, globally, up to 40 per cent of all picked fruit can be lost and this represents billions of dollars. But what if we had the technology to delay fruit’s natural degradation process? This is where hexanal can make a difference.

Hexanal is naturally produced by plants to ward off pests; our research at the University of Guelph has found that when it’s applied externally, hexanal can also slow down the aging process.

Like everything else, fruit ages with time. The shrivelling and rot is triggered by the enzyme phospholipase D (PLD), which causes the eventual collapse of the fruit’s membrane. Essentially, fruit membranes are snug, and function like a brick wall of phospholipid bilayers. Phospholipase D breaks the alignment of the bricks, causing the membrane to crumble. Hexanal acts by reducing and slowing the formation of PLD, which in turn slows the collapse of the fruit’s membrane.

In partnership with agricultural and social science researchers in Canada and five other countries, we have tested nine hexanal technologies. These include a spray formulation that gets applied to fruit when they’re still on trees, post-harvest dips, fruit wraps, stickers and sachets embedded with hexanal.

Our findings have implications for consumers, retailers and, more importantly, farmers. For example, when applied as a pre-harvest spray, hexanal can keep fruit on trees longer and keep it fresher after harvest — up to three weeks longer for mangoes.

Hexanal is naturally produced by all plants and is already found as an additive in some food products. Hexanal is also approved by Health Canada as a flavour formula. Our tests of synthesized hexanal sprays, dips and other technologies showed that there were no negative effects on plants, insects or other animals. In addition, hexanal evaporates within 24 hours, which means there’s no residue left on fruit.

Farmers who participated in hexanal testing in Canada and elsewhere were happy with the product both in terms of its effectiveness and bio-safety.

Currently, hexanal for agricultural use is in the two-year regulatory clearance process in Canada and the U.S. Once the process is complete, hexanal formulations are expected to be available for farmer use and can be accessed through companies with a license for production.

Hexanal slows down the ripening and aging process in fresh produce. Author provided

That’s a stunning difference, eh?

Funding

At about the same time as the Conversation essay by Subramanian and Finnis, the University of Guelph published (on the Council of Ontario Universities website) a January 27, 2019 news release announcing new funds for the project,

A University of Guelph research project that has already improved the livelihoods of small-scale Asian farmers will further expand worldwide, thanks to more than $4.2 million in federal support announced Friday afternoon.

The project involves innovative packaging developed in part by Guelph researchers using nanotechnology to improve the shelf life of mangoes, a major fruit crop in much of the world.

Already, the technology has helped to significantly reduce post-harvest losses in Sri Lanka and India. Poor storage meant that farmers routinely lost up to 40 per cent of their crops, worth upwards of $800 million a year. The new technology has also boosted per-acre revenue.

New funding support from the International Development Research Centre (IDRC) and Foreign Affairs, Trade and Development Canada will allow researchers to broaden this successful initiative to Kenya, Tanzania, and Trinidad and Tobago.

Researchers will also look at other fruit — bananas, grapes, papaya, nectarines and berries — and investigate ways to commercialize the technologies.

… it will also be a main pillar of the Guelph-East Africa Initiative, which U of G established to bring together stakeholders to support research and teaching in food, health, water, education, environment and community.

“This confirms our commitment to improve agriculture in East Africa and around the world.” [said John Livernois, interim vice-president {research} ]

The project involves the use of hexanal, a natural plant product that delays fruit ripening and aging. Guelph plant agriculture professor Gopi Paliyath holds an American patent on the discovery of hexanal as a post-harvest agent. It’s also an FDA-approved food additive.

The project also involves Guelph plant agriculture professors Paliyath and Al Sullivan; Loong-tak Lim from Food Science; and Elizabeth Finnis, Sociology and Anthropology. Foreign research partners are based at Tamil Nadu Agricultural University, India; Industrial Technical Institute, Sri Lanka; University of Nairobi, Kenya; Sokoine University of Agriculture, Tanzania; and the University of [the] West Indies, Trinidad and Tobago.

Prior to more funding: a memorandum of understanding

I’m having to guess as the document about the memorandum of understanding (MOU) to commercialize hexanal is not dated but it seems to have been produced in March 2018. (Canada’s International Development Research Centre ([IDRC] has a webpage about the memorandum but no memorandum that I could find.) I stumbled across this account of the event where the MOU was signed,

Ms. Jennifer Daubeny, Consulate General of Canada, delivered the special address narrating the significance of Canadian fundingin developing nanotechnologies to reduce post-harvest losses that enables food security in Asian Countries. Dr. K. Ramasamy, Vice Chancellor, Tamil Nadu Agricultural University [TNAU], Coimbatore presided over the function and highlighted the role of TNAU in knitting nanotechnology research framework and serving as a torch bearer in the country. He emphasized that the GAC-IDRC Project helped more than 60 students and researchers, developed two technologies, filed patents for two inventions, extensive infrastructure development besides helping more than 12,000 fruit growers in the State of Tamil Nadu. Dr. Jayasankar Subramanian, Professor, University of Guelph, Canada, explained the evolution of the project till reached the stage of technology delivery to benefit farmers. Dr. K.S. Subramanian, NABARD Chair Professor, TNAU, Coimbatore, lead Principal Investigator of the Project for India presented nanotechnologies developed to assist in the entire value chain from the farm to fork. Mr. Arun Nagarajan, President, Tamil Nadu Fruit Growers’ Association, explained that the fruit growers are eager to use the technology to improve their farm income. Mr. Terence Park, Managing Director, Smart Harvest Agri, Canada, [emphasis mine] bestowed interest to take forward the technologies to the farm gate and signed MOU with TNAU for the Commercialization of the Hexanal Formulation. Dr. G.J. Janavi,Professor & Head, Department of Nano Science & Technology, TNAU, Coimbatore welcomed the gathering and Dr. C. Sekar, Dean, Imayam Agricultural College,Turaiyur, and Co-PI of the Project proposed a formal vote of thanks.

The Canadian Consul General Ms. Jennifer Daubeny visited all the exhibits and interacted with students, scholars and researchers besides the NGO partner Myrada. She was very impressed with the technologies developed by TNAU in collaboration with University of Guelph, Canada, and looking forward to support research programs in the near future. More than 200 Scientists and Diplomats from Canada, students, scholars, university officials participated in the event.

Products launch by ITI, Colombo

Two of the project’s technology outputs -hexanal incorporated ITI Bio-wax and the Tree Fresh Formulation spray [emphasis mine] were transferred to Hayleys Agriculture Pvt. Ltd., a reputed Agro Service provider in Sri Lanka. The products were launched on 22ndMarch 2018 at the Taj Samudra Hotel, Colombo. The chief guest at the event was the Hon. Susil Premajayantha, Minister of Science Technology and Research (Min. ST&R). The guest of honour was H.E. David McKinnon, High Commissioner for Canada in Sri Lanka. Others present included the Secretary to the Min. ST&R, The Chairman and Director General, ITI, Mr Rizvi Zaheed, Hayleys Agriculture and his team, the Chairman, National Science Foundation, Sri Lanka, representative of the Chairman Sri Lanka Export Development Board, representatives from the Dialog mobile service provider, the Registrar of Pesticides, representing the Dir. Gen., of Agriculture, President of the Lanka Fruit and Vegetable Producers, Processors and Exporters Association, leading large scale mango, papaya and pineapple growers, several export and fruit processing company representatives, senior officials from the ITI, the multi-disciplinary ITI research team and our partner from CEPA. The press was also well represented and a total of 100 persons were present on this occasion. The Managing Director Hayles, the two PIs’ of the project, the High Commissioner for Canada, The Minister and for ST&R and the Secretary to the Ministry addressed the gathering and the new video clip on the project was viewed. The new products were jointly uncovered for display by the Hon. Minister and H.E., the High Commissioner. Samples of the products were distributed to the President of the Lanka Fruit and Vegetable Producers Processors and Exporters Association and to two leading mango growers. The Project team also took this opportunity to run a presentation on the various stages of the project and related activities, display posters on their research findings and to print and distribute the pamphlets on the same as well as on hexanal, the latter as prepared by our partners from the University of Guelph. The launch ended with a time of fellowship providing a useful opportunity for networking.

A YouTube video about the product launch of hexanal-based Bio-wax and the Tree Fresh Formulation spray (I don’t know if those were the permanent names or if they are specific to Sri Lanka and other countries will adopt other names) helped to establish the date for the MOU. You can find the video here.

Judging from the media stories, the team in India has provided most of the leadership for commercializing hexanal.

Commercialization 2019 and beyond

To sum up, after a memorandum of understanding is signed and some prototype products have been unveiled in India in 2018 then, in early 2019, there’s more funding announced by IDRC to expand the number of countries involved and to continue research into efforts to save other types of produce.

Moving things along is an August 15, 2019 news item on Agropages.com,

Two nano formulations would be commercialized by the Directorate of Agri business development of Tamil Nadu Agricultural University (TNAU) soon.  

Fruity fresh is a liquid nano formulation containing hexanal that keeps fruits and vegetables fresh for more days. The pre-harvest spray of Fruity Fresh extends the shelf life of mango for two weeks on trees and another two weeks under storage conditions by employing post-harvest dip methodology, Dr. A. Lakshmanan, Professor and Head, Department of Nano Science and Technology told a meet on “Linking Nano Stakeholders” held at the University.  

Hexanal has also been successfully encapsulated in polymer matrix either as an electro spun fibre matrix (Nano sticker) or nano-pellets that extends shelf life of fruits by 1-2 weeks during storage and transportation, he said.  

This sticker and pellets technology is highly user friendly and can be placed inside the cartons containing fruits during transport for enhancing the freshness.

According to a November 5, 2019 article by Pearly Neo for foodnavigator-asia.com, there is pricing for four products. Nano Sticker and Nano Pellet each will cost $US 0.028 and the spray, Fruity Fresh, will cost $US 4.23 to $US 5.65 for a one liter bottle diluted in 50 liters of water (for use on approximately five trees) and the Fruity Fresh dipping solution at $US 0.0071per kg.

As far as I’m aware none of these products are available in Canada but there is a website for Smart Harvest Agri, Canada although the name used is a little different. First, there’s the Federal Corporation Information listing for Smart Harvest Agritech Limited. You’ll notice there are two directors,

Amanjit Singh Bains
7685 150B Street
Surrey BC V3S 5P1
Canada

Terence Park
Yongsan CJ Nine Park
Seoul
Korea, Republic of

The company’s Smart Harvest website doesn’t list any products but it does discuss something they call “FRESHXtend technology” for fruits and vegetables.

Final comment

I sometimes hear complaints about government funding and what seems to be a lack of follow through with exciting research work being done in Canada. I hope that in the months to come that this story of an international collaboration, which started with three countries and has now expanded to at least six countries and has led to increased food security with an environmentally friendly material and commercialization of research, gets some attention.

From the few sources I’ve been able to find, it seems India and Sri Lanka are leading the commercialization charge while Canada has contributed to an Asian-led project which has now expanded to include Kenya, Tanzania, and Trinidad and Tobago. Bravo t them all!

Science and technology, the 2019 Canadian federal government, and the Phoenix Pay System

This posting will focus on science, technology, the tragic consequence of bureaucratic and political bungling (the technology disaster that is is the Phoenix payroll system), and the puzzling lack of concern about some of the biggest upcoming technological and scientific changes in government and society in decades or more.

Setting the scene

After getting enough Liberal party members elected to the Canadian Parliament’s House of Commons to form a minority government in October 2019, Prime Minister Justin Trudeau announced a new cabinet and some changes to the ‘science’ portfolios in November 2019. You can read more about the overall cabinet announcement in this November 20, 2019 news item by Peter Zimonjic on the Canadian Broadcasting Corporation (CBC) website, my focus will be the science and technology. (Note: For those who don’t know, there is already much discussion about how long this Liberal minority government will last. All i takes is a ‘loss of confidence’ motion and a majority of the official opposition and other parties to vote ‘no confidence’ and Canada will back into the throes of an election. Mitigating against a speedy new federal election,, the Conservative party [official opposition] needs to choose a new leader and the other parties may not have the financial resources for another federal election so soon after the last one.)

Getting back to now and the most recent Cabinet announcements, it seems this time around, there’s significantly less interest in science. Concerns about this were noted in a November 22, 2019 article by Ivan Semeniuk for the Globe and Mail,

Canadian researchers are raising concerns that the loss of a dedicated science minister signals a reduced voice for their agenda around the federal cabinet table.

“People are wondering if the government thinks its science agenda is done,” said Marie Franquin, a doctoral student in neuroscience and co-president of Science and Policy Exchange, a student-led research-advocacy group. “There’s still a lot of work to do.”

While not a powerful player within cabinet, Ms. Duncan [Kirsty Duncan] proved to be an ardent booster of Canada’s research community and engaged with its issues, including the muzzling of federal scientists by the former Harper government and the need to improve gender equity in the research ecosystem.

Among Ms. Duncan’s accomplishments was the appointment of a federal chief science adviser [sic] and the commissioning of a landmark review of Ottawa’s support for fundamental research, chaired by former University of Toronto president David Naylor

… He [Andre Albinati, managing principal with Earnscliffe Strategy Group] added the role of science in government is now further bolstered by chief science adviser [sic] Mona Nemer and a growing network of departmental science advisers [sic]. .

Mehrdad Hariri, president of the Canadian Science Policy Centre …, cautioned that the chief science adviser’s [sic] role was best described as “science for policy,” meaning the use of science advice in decision-making. He added that the government still needed a separate role like that filled by Ms. Duncan … to champion “policy for science,” meaning decisions that optimize Canada’s research enterprise.

There’s one other commentary (by CresoSá) but I’m saving it for later.

The science minister disappears

There is no longer a separate position for Science. Kirsty Duncan was moved from her ‘junior’ position as Minister of Science (and Sport) to Deputy Leader of the government. Duncan’s science portfolio has been moved over to Navdeep Bains whose portfolio evolved from Minister of Innovation, Science and Economic Development (yes, there were two ‘ministers of science’) to Minister of Innovation, Science and Industry. (It doesn’t make a lot of sense to me. Sadly, nobody from the Prime Minister’s team called to ask for my input on the matter.)

Science (and technology) have to be found elsewhere

There’s the Natural Resources (i.e., energy, minerals and metals, forests, earth sciences, mapping, etc.) portfolio which was led by Catherine McKenna who’s been moved over to Infrastructure and Communities. There have been mumblings that she was considered ‘too combative’ in her efforts. Her replacement in Natural Resources is Seamus O’Regan. No word yet on whether or not, he might also be ‘too combative’. Of course, it’s much easier if you’re female to gain that label. (You can read about the spray-painted slurs found on the windows of McKenna’s campaign offices after she was successfully re-elected. See: Mike Blanchfield’s October 24, 2019 article for Huffington Post and Brigitte Pellerin’s October 31, 2019 article for the Ottawa Citizen.)

There are other portfolios which can also be said to include science such as Environment and Climate Change which welcomes a new minister, Jonathan Wilkinson moving over from his previous science portfolio, Fisheries, Oceans, and Canadian Coast Guard where Bernadette Jordan has moved into place. Patti Hajdu takes over at Heath Canada (which despite all of the talk about science muzzles being lifted still has its muzzle in place). While it’s not typically considered a ‘science’ portfolio in Canada, the military establishment regardless of country has long been considered a source of science innovation; Harjit Sajjan has retained his Minister of National Defence portfolio.

Plus there are at least half a dozen other portfolios that can be described as having significant science and/or technology elements folded into their portfolios, e.g., Transport Canada, Agriculture and Agri-Food, Safety and Emergency Preparedness, etc.

As I tend to focus on emerging science and technology, most of these portfolios are not ones I follow even on an irregular basis meaning I have nothing more to add about them in this posting. Mixing science and technology together in this posting is a reflection of how tightly the two are linked together. For example, university research into artificial intelligence is taking place on theoretical levels (science) and as applied in business and government (technology). Apologies to the mathematicians but this explanation is already complicated and I don’t think I can do justice to their importance.

Moving onto technology with a strong science link, this next portfolio received even less attention than the ‘science’ portfolios and I believe that’s undeserved.

The Minister of Digital Government and a bureaucratic débacle

These days people tend to take the digital nature of daily life for granted and that may be why this portfolio has escaped much notice. When the ministerial posting was first introduced, it was an addition to Scott Brison’s responsibilities as head of the Treasury Board. It continued to be linked to the Treasury Board when Joyce Murray* inherited Brison’s position, after his departure from politics. As of the latest announcement in November 2019, Digital Government and the Treasury Board are no longer tended to by the same cabinet member.

The new head of the Treasury Board is Jean-Yves Duclos while Joyce Murray has held on to the Minister of Digital Government designation. I’m not sure if the separation from the Treasury Board is indicative of the esteem the Prime Minister has for digital government or if this has been done to appease someone or some group, which means the digital government portfolio could well disappear in the future just as the ‘junior’ science portfolio did.

Regardless, here’s some evidence as to why I think ‘digital government’ is unfairly overlooked, from the minister’s December 13, 2019 Mandate Letter from the Prime Minister (Note: All of the emphases are mine],

I will expect you to work with your colleagues and through established legislative, regulatory and Cabinet processes to deliver on your top priorities. In particular, you will:

  • Lead work across government to transition to a more digital government in order to improve citizen service.
  • Oversee the Chief Information Officer and the Canadian Digital Service as they work with departments to develop solutions that will benefit Canadians and enhance the capacity to use modern tools and methodologies across Government.
  • Lead work to analyze and improve the delivery of information technology (IT) within government. This work will include identifying all core and at-risk IT systems and platforms. You will lead the renewal of SSC [Shared Services Canada which provides ‘modern, secure and reliable IT services so federal organizations can deliver digital programs and services to meet Canadians’ needs’] so that it is properly resourced and aligned to deliver common IT infrastructure that is reliable and secure.
  • Lead work to create a centre of expertise that brings together the necessary skills to effectively implement major transformation projects across government, including technical, procurement and legal expertise.
  • Support the Minister of Innovation, Science and Industry in continuing work on the ethical use of data and digital tools like artificial intelligence for better government.
  • With the support of the President of the Treasury Board and the Minister of Families, Children and Social Development, accelerate progress on a new Government of Canada service strategy that aims to create a single online window for all government services with new performance standards.
  • Support the Minister of Families, Children and Social Development in expanding and improving the services provided by Service Canada.
  • Support the Minister of National Revenue on additional steps required to meaningfully improve the satisfaction of Canadians with the quality, timeliness and accuracy of services they receive from the Canada Revenue Agency.
  • Support the Minister of Public Services and Procurement in eliminating the backlog of outstanding pay issues for public servants as a result of the Phoenix Pay System.
  • Lead work on the Next Generation Human Resources and Pay System to replace the Phoenix Pay System and support the President of the Treasury Board as he actively engages Canada’s major public sector unions.
  • Support the Minister of Families, Children and Social Development and the Minister of National Revenue to implement a voluntary, real-time e-payroll system with an initial focus on small businesses.
  • Fully implement lessons learned from previous information technology project challenges and failures [e,g, the Phoenix Payroll System], particularly around sunk costs and major multi-year contracts. Act transparently by sharing identified successes and difficulties within government, with the aim of constantly improving the delivery of projects large and small.
  • Encourage the use and development of open source products and open data, allowing for experimentation within existing policy directives and building an inventory of validated and secure applications that can be used by government to share knowledge and expertise to support innovation.

To be clear, the Minister of Digital Government is responsible (more or less) for helping to clean up a débacle, i.e., the implementation of the federal government’s Phoenix Payroll System and drive even more digitization and modernization of government data and processes.

They’ve been trying to fix the Phoenix problems since the day it was implemented in early 2016.That’s right, it will be four years in Spring 2020 when the Liberal government chose to implement a digital payroll system that had been largely untested and despite its supplier’s concerns.

The Phoenix Pay System and a great sadness

The Public Service Alliance of Canada (the largest union for federal employees; PSAC) has a separate space for Phoneix on its website, which features this video,

That video was posted on September 24, 2018 (on YouTube) and, to my knowledge, the situation has not changed appreciably. A November 8, 2019 article by Tom Spears for the Ottawa Citizen details a very personal story about what can only be described as a failure on just about every level you can imagine,

Linda Deschâtelets’s death by suicide might have been prevented if the flawed Phoenix pay system hadn’t led her to emotional and financial ruin, a Quebec coroner has found.

Deschâtelets died in December of 2017, at age 52. At the time she was struggling with chronic pain and massive mortgage payments.

The fear of losing her home weighed heavily on her. In her final text message to one of her sons she said she had run out of energy and wanted to die before she lost her house in Val des Monts.

But Deschâtelets might have lived, says a report from coroner Pascale Boulay, if her employer, the Canada Revenue Agency, had shown a little empathy.

“During the final months before her death, she experienced serious financial troubles linked to the federal government’s pay system, Phoenix, which cut off her pay in a significant way, making her fear she would lose her house,” said Boulay’s report.

“A thorough analysis of this case strongly suggests that this death could have been avoided if a search for a solution to the current financial, psychological and medical situation had been made.”

Boulay found “there is no indication that management sought to meet Ms. Deschâtelets to offer her options. In addition, the lack of prompt follow-up in the processing of requests for information indicates a distressing lack of empathy for an employee who is experiencing real financial insecurity.”

Pay records “indeed show that she was living through serious financial problems and that she received irregular payments since the beginning of October 2017,” the coroner wrote.

As well, “her numerous online applications using the form for a compensation problem, in which she expresses her fear of not being able to make her mortgage payments and says that she wants a detailed statement of account, remain unanswered.”

On top of that, she had chronic back pain and sciatica and had been missing work. She was scheduled to get an ergonomically designed work area, but this change was never made even though she waited for months.

Money troubles kept getting worse.

She ran out of paid sick leave, and her department sent her an email to explain that she had automatically been docked pay for taking sick days. “In this same email, she was also advised that in the event that she missed additional days, other amounts would be deducted. No further follow-up with her was done,” the coroner wrote.

That email came eight days before her death.

Deschâtelets was also taking cocaine but this did not alter the fact that she genuinely risked losing her home over her financial problems, the coroner wrote.

“Given the circumstances, it is highly likely that Ms. Deschâtelets felt trapped” and ended her life “because of her belief that she would lose the house anyway. It was only a matter of time.”

The situation is “even more sad” because CRA had advisers on site who dealt with Phoenix issues, and could meet with employees, Boulay wrote.

“The federal government does a lot of promotion of workplace wellness. Surprisingly, these wellness measures are silent on the subject of financial insecurity at work,” Boulay wrote.

I feel sad for the family and indignant that there doesn’t seem to have been enough done to mitigate the hardships due to an astoundingly ill-advised decision to implement an untested payroll system for the federal government’s 280,000 or more civil servants.

Canada’s Senate reports back on Phoenix

I’m highlighting the Senate report here although there are also two reports from the Auditor General should you care to chase them down. From an August 1, 2018 article by Brian Jackson for IT World Canada,

In February 2016, in anticipation of the start of the Phoenix system rolling out, the government laid off 2,700 payroll clerks serving 120,000 employees. [I’m guessing the discrepancy in numbers of employees may be due to how the clerks were laid off, i.e., if they were load off in groups scheduled to be made redundant at different intervals.]

As soon as Phoenix was launched, problems began. By May 2018 there were 60,000 pay requests backlogged. Now the government has dedicated resources to explaining to affected employees the best way to avoid pay-related problems, and to file grievances related to the system.

“The causes of the failure are multiple, including, failing to manage the pay system in an integrated fashion with human resources processes, not conducting a pilot project, removing essential processing functions to stay on budget, laying off experienced compensation advisors, and implementing a pay system that wasn’t ready,” the Senate report states. “We are dismayed that this project proceeded with minimal independent oversight, including from central agencies, and that no one has accepted responsibility for the failure of Phoenix or has been held to account. We believe that there is an underlying cultural problem that needs to be addressed. The government needs to move away from a culture that plays down bad news and avoids responsibility, [emphasis mine] to one that encourages employee engagement, feedback and collaboration.”

There is at least one estimate that the Phoenix failure will cost $2.2 billion but I’m reasonably certain that figure does not include the costs of suicide, substance abuse, counseling, marriage breakdown, etc. (Of course, how do you really estimate the cost of a suicide or a marriage breakdown or the impact that financial woes have on children?)

Also concerning the Senate report, there is a July 31, 2018 news item on CBC (Canadian Broadcasting Corporation) news online,

“We are not confident that this problem has been solved, that the lessons have all been learned,” said Sen. André Pratte, deputy chair of the committee. [emphases mine]

I haven’t seen much coverage about the Phoenix Pay System recently in the mainstream media but according to a December 4, 2019 PSAC update,

The Parliamentary Budget Officer has said the Phoenix situation could continue until 2023, yet government funding commitments so far have fallen significantly short of what is needed to end the Phoenix nightmare. 

PSAC will continue pressing for enough funding and urgent action:

  • eliminate the over 200,000 cases in the pay issues backlog
  • compensate workers for their many hardships
  • stabilize Phoenix
  • properly develop, test and launch a new pay system

2023 would mean the débacle had a seven year lifespan, assuming everything has been made better by then.

Finally, there seems to be one other minister tasked with the Phoenix Pay System ‘fix’ (December 13, 2019 mandate letter) and that is the Minister of Public Services and Procurement, Anita Anand. She is apparently a rookie MP (member of Parliament), which would make her a ‘cabinet rookie’ as well. Interesting choice.

More digital for federal workers and the Canadian public

Despite all that has gone before, the government is continuing in its drive to digitize itself as can be seen in the Minister of Digital Government’s mandate letter (excerpted above in ‘The Minister of Digital Government and some …’ subsection) and on the government’s Digital Government webspace,

Our digital shift to becoming more agile, open, and user-focused. We’re working on tomorrow’s Canada today.

I don’t find that particularly reassuring in light of the Phoenix Payroll System situation. However, on the plus side, Canada has a Digital Charter with 10 principles which include universal access, safety and security, control and consent, etc. Oddly, it looks like it’s the Minister of Justice and Attorney General of Canada, the Minister of Canadian Heritage and the Minister of Innovation, Science and Industry who are tasked with enhancing and advancing the charter. Shouldn’t this group also include the Minister of Digital Government?

The Minister of Digital Government, Joyce Murray, does not oversee a ministry and I think that makes this a ‘junior’ position in much the same way the Minister of Science was a junior position. It suggests a mindset where some of the biggest changes to come for both employees and the Canadian public are being overseen by someone without the resources to do the work effectively or the bureaucratic weight and importance to ensure the changes are done properly.

It’s all very well to have a section on the Responsible use of artificial intelligence (AI) on your Digital Government webspace but there is no mention of ways and means to fix problems. For example, what happens to people who somehow run into an issue that the AI system can’t fix or even respond to because the algorithm wasn’t designed that way. Ever gotten caught in an automated telephone system? Or perhaps more saliently, what about the people who died in two different airplane accidents due to the pilots’ poor training and an AI system? (For a more informed view of the Boeing 737 Max, AI, and two fatal plane crashes see: a June 2, 2019 article by Rachel Kraus for Mashable.)

The only other minister whose mandate letter includes AI is the Minister of Innovation, Science and Industry, Navdeep Bains (from his December 13, 2019 mandate letter),

  • With the support of the Minister of Digital Government, continue work on the ethical use of data and digital tools like artificial intelligence for better government.

So, the Minister of Digital Government, Joyce Murray, is supporting the Minister of Innovation, Science and Industry, Navdeep Bains. That would suggest a ‘junior’ position wouldn’t it? If you look closely at the Minister of Digital Services’ mandate letter, you’ll see the Minister is almost always supporting another minister.

Where the Phoenix Pay System is concerned, the Minister of Digital Services is supporting the Minister of Public Services and Procurement, the previously mentioned rookie MP and rookie Cabinet member, Anita Anand. Interestingly, the employees’ union, PSAC, has decided (as of a November 20, 2019 news release) to ramp up its ad campaign regarding the Phoenix Pay System and its bargaining issues by targeting the Prime Minister and the new President of the Treasury Board, Jean-Yves Duclos. Guess whose mandate letter makes no mention of Phoenix (December 13, 2019 mandate letter for the President of the Treasury Board).

Open government, eh?

Putting a gift bow on a pile of manure doesn’t turn it into a gift (for most people, anyway) and calling your government open and/or transparent doesn’t necessarily make it so even when you amend your Access to Information Act to make it more accessible (August 22, 2019 Digital Government news release by Ruth Naylor).

One of the Liberal government’s most heavily publicized ‘open’ initiatives was the lifting of the muzzles put on federal scientists in the Environment and Natural Resources ministries. Those muzzles were put into place by a Conservative government and the 2015 Liberal government gained a lot of political capital from its actions. No one seemed to remember that Health Canada also had been muzzled. That muzzle had been put into place by one of the Liberal governments preceding the Conservative one. To date there is no word as to whether or not that muzzle has ever been lifted.

However, even in the ministries where the muzzles were lifted, it seems scientists didn’t feel free to speak even many months later (from a Feb 21, 2018 article by Brian Owens for Science),

More than half of government scientists in Canada—53%—do not feel they can speak freely to the media about their work, even after Prime Minister Justin Trudeau’s government eased restrictions on what they can say publicly, according to a survey released today by a union that represents more than 16,000 federal scientists.

That union—the Professional Institute of the Public Service of Canada (PIPSC) based in Ottawa—conducted the survey last summer, a little more than a year and a half into the Trudeau government. It followed up on a similar survey the union released in 2013 at the height of the controversy over the then-Conservative government’s reported muzzling of scientists by preventing media interviews and curtailing travel to scientific conferences. The new survey found the situation much improved—in 2013, 90% of scientists felt unable to speak about their work. But the union says more work needs to be done. “The work needs to be done at the department level,” where civil servants may have been slow to implement political directives, PIPSC President Debi Daviau said. ”We need a culture change that promotes what we have heard from ministers.”

I found this a little chilling (from the PIPSC Defrosting Public Science; a 2017 survey of federal scientists webpage),

To better illustrate this concern, in 2013, The Big Chill revealed that 86% of respondents feared censorship or retaliation from their department or agency if they spoke out about a departmental decision or action that, based on their scientific knowledge, could bring harm to the public interest. In 2017, when asked the same question, 73% of respondents said they would not be able to do so without fear of censorship or retaliation – a mere 13% drop.

It’s possible things have improved but while the 2018 Senate report did not focus on scientists, it did highlight issues with the government’s openness and transparency or in their words: “… a culture that plays down bad news and avoids responsibility.” It seems the Senate is not the only group with concerns about government culture; so do the government’s employees (the scientists, anyway).

The other science commentary

I can’t find any commentary or editorials about the latest ministerial changes or the mandate letters on the Canadian Science Policy Centre website so was doubly pleased to find this December 6, 2019 commentary by Creso Sá for University Affairs,

The recently announced Liberal cabinet brings what appear to be cosmetic changes to the science file. Former Science Minister Kirsty Duncan is no longer in it, which sparked confusion among casual observers who believed that the elimination of her position signalled the termination of the science ministry or the downgrading of the science agenda. In reality, science was and remains part of the renamed Ministry of Innovation, Science, and (now) Industry (rather than Economic Development), where Minister Navdeep Bains continues at the helm.

Arguably, these reactions show that appearances have been central [emphasis mine] to the modus operandi of this government. Minister Duncan was an active, and generally well-liked, champion for the Trudeau government’s science platform. She carried the torch of team science over the last four years, becoming vividly associated with the launch of initiatives such as the Fundamental Science Review, the creation of the chief science advisor position, and the introduction of equity provisions in the Canada Research Chairs program. She talked a good talk, but her role did not in fact give her much authority to change the course of science policy in the country. From the start, her mandate was mostly defined around building bridges with members of cabinet, which was likely good experience for her new role of deputy house leader.

Upon the announcement of the new cabinet, Minister Bains took to Twitter to thank Dr. Duncan for her dedication to placing science in “its rightful place back at the centre of everything our government does.” He indicated that he will take over her responsibilities, which he was already formally responsible for. Presumably, he will now make time to place science at the centre of everything the government does.

This kind of sloganeering has been common [emphasis mine] since the 2015 campaign, which seems to be the strategic moment the Liberals can’t get out of. Such was the real and perceived hostility of the Harper Conservatives to science that the Liberals embraced the role of enlightened advocates. Perhaps the lowest hanging fruit their predecessors left behind was the sheer absence of any intelligible articulation of where they stood on the science file, which the Liberals seized upon with gusto. Virtue signalling [emphasis mine] became a first line of response.

When asked about her main accomplishments over the past year as chief science advisor at the recent Canadian Science Policy Conference in Ottawa, Mona Nemer started with the creation of a network of science advisors across government departments. Over the past four years, the government has indeed not been shy about increasing the number of appointments with “science” in their job titles. That is not a bad thing. We just do not hear much about how “science is at the centre of everything the government does.” Things get much fuzzier when the conversation turns to the bold promises of promoting evidence-based decision making that this government has been vocal about. Queried on how her role has impacted policy making, Dr. Nemer suggested the question should be asked to politicians. [emphasis mine]

I’m tempted to describe the ‘Digital Government’ existence and portfolio as virtue signalling.

Finally

There doesn’t seem to be all that much government interest in science or, even, technology for that matter. We have a ‘junior’ Minister of Science disappear so that science can become part of all the ministries. Frankly, I wish that science were integrated throughout all the ministries but when you consider the government culture, this move more easily lends itself to even less responsibility being taken by anyone. Take another look at the Canada’s Chief Science Advisor’s comment: “Queried on how her role has impacted policy making, Dr. Nemer suggested the question should be asked to politicians.” Meanwhile, we get a ‘junior Minister of Digital Government whose portfolio has the potential to affect Canadians of all ages and resident in Canada or not.

A ‘junior’ minister is not necessarily evil as Sá points out but I would like to see some indication that efforts are being made to shift the civil service culture and the attitude about how the government conducts its business and that the Minister of Digital Government will receive the resources and the respect she needs to do her job. I’d also like to see some understanding of how catastrophic a wrong move has already been and could be in the future along with options for how citizens are going to be making their way through this brave new digital government world and some options for fixing problems, especially the catastrophic ones.

*December 30, 2019 correction: After Scott Brison left his position as President of the Treasury Board and Minister of Digital Government in January 2019, Jane Philpott held the two positions until March 2019 when she left the Liberal Party. Carla Quatrough was acting head from March 4 – March 18, 2019 when Joyce Murray was appointed to the two positions which she held for eight months until November 2019 when, as I’ve noted, the ‘Minister of Digital Government’ was split from the ‘President of the Treasury Board’ appointment.

ETA January 28, 2020: The Canadian Broadcasting Corporation (CBC) has an update on the Phoenix Pay System situation in a January 28, 2020 posting (supplied by The Canadian Press),

More than 98,000 civil servants may still owe the federal government money after being overpaid through the disastrous Phoenix pay system.

… the problems persist, despite the hiring of hundreds of pay specialists to work through a backlog of system errors.

The public service pay centre was still dealing with a backlog of about 202,000 complaints as of Dec. 24 [2019], down from 214,000 pay transactions that went beyond normal workload in November [2019].

Gene editing and personalized medicine: Canada

Back in the fall of 2018 I came across one of those overexcited pieces about personalized medicine and gene editing tha are out there. This one came from an unexpected source, an author who is a “PhD Scientist in Medical Science (Blood and Vasculature” (from Rick Gierczak’s LinkedIn profile).

It starts our promisingly enough although I’m beginning to dread the use of the word ‘precise’  where medicine is concerned, (from a September 17, 2018 posting on the Science Borealis blog by Rick Gierczak (Note: Links have been removed),

CRISPR-Cas9 technology was accidentally discovered in the 1980s when scientists were researching how bacteria defend themselves against viral infection. While studying bacterial DNA called clustered regularly interspaced short palindromic repeats (CRISPR), they identified additional CRISPR-associated (Cas) protein molecules. Together, CRISPR and one of those protein molecules, termed Cas9, can locate and cut precise regions of bacterial DNA. By 2012, researchers understood that the technology could be modified and used more generally to edit the DNA of any plant or animal. In 2015, the American Association for the Advancement of Science chose CRISPR-Cas9 as science’s “Breakthrough of the Year”.

Today, CRISPR-Cas9 is a powerful and precise gene-editing tool [emphasis mine] made of two molecules: a protein that cuts DNA (Cas9) and a custom-made length of RNA that works like a GPS for locating the exact spot that needs to be edited (CRISPR). Once inside the target cell nucleus, these two molecules begin editing the DNA. After the desired changes are made, they use a repair mechanism to stitch the new DNA into place. Cas9 never changes, but the CRISPR molecule must be tailored for each new target — a relatively easy process in the lab. However, it’s not perfect, and occasionally the wrong DNA is altered [emphasis mine].

Note that Gierczak makes a point of mentioning that CRISPR/Cas9 is “not perfect.” And then, he gets excited (Note: Links have been removed),

CRISPR-Cas9 has the potential to treat serious human diseases, many of which are caused by a single “letter” mutation in the genetic code (A, C, T, or G) that could be corrected by precise editing. [emphasis mine] Some companies are taking notice of the technology. A case in point is CRISPR Therapeutics, which recently developed a treatment for sickle cell disease, a blood disorder that causes a decrease in oxygen transport in the body. The therapy targets a special gene called fetal hemoglobin that’s switched off a few months after birth. Treatment involves removing stem cells from the patient’s bone marrow and editing the gene to turn it back on using CRISPR-Cas9. These new stem cells are returned to the patient ready to produce normal red blood cells. In this case, the risk of error is eliminated because the new cells are screened for the correct edit before use.

The breakthroughs shown by companies like CRISPR Therapeutics are evidence that personalized medicine has arrived. [emphasis mine] However, these discoveries will require government regulatory approval from the countries where the treatment is going to be used. In the US, the Food and Drug Administration (FDA) has developed new regulations allowing somatic (i.e., non-germ) cell editing and clinical trials to proceed. [emphasis mine]

The potential treatment for sickle cell disease is exciting but Gierczak offers no evidence that this treatment or any unnamed others constitute proof that “personalized medicine has arrived.” In fact, Goldman Sachs, a US-based investment bank, makes the case that it never will .

Cost/benefit analysis

Edward Abrahams, president of the Personalized Medicine Coalition (US-based), advocates for personalized medicine while noting in passing, market forces as represented by Goldman Sachs in his May 23, 2018 piece for statnews.com (Note: A link has been removed),

One of every four new drugs approved by the Food and Drug Administration over the last four years was designed to become a personalized (or “targeted”) therapy that zeros in on the subset of patients likely to respond positively to it. That’s a sea change from the way drugs were developed and marketed 10 years ago.

Some of these new treatments have extraordinarily high list prices. But focusing solely on the cost of these therapies rather than on the value they provide threatens the future of personalized medicine.

… most policymakers are not asking the right questions about the benefits of these treatments for patients and society. Influenced by cost concerns, they assume that prices for personalized tests and treatments cannot be justified even if they make the health system more efficient and effective by delivering superior, longer-lasting clinical outcomes and increasing the percentage of patients who benefit from prescribed treatments.

Goldman Sachs, for example, issued a report titled “The Genome Revolution.” It argues that while “genome medicine” offers “tremendous value for patients and society,” curing patients may not be “a sustainable business model.” [emphasis mine] The analysis underlines that the health system is not set up to reap the benefits of new scientific discoveries and technologies. Just as we are on the precipice of an era in which gene therapies, gene-editing, and immunotherapies promise to address the root causes of disease, Goldman Sachs says that these therapies have a “very different outlook with regard to recurring revenue versus chronic therapies.”

Let’s just chew on this one (contemplate)  for a minute”curing patients may not be ‘sustainable business model’!”

Coming down to earth: policy

While I find Gierczak to be over-enthused, he, like Abrahams, emphasizes the importance of new policy, in his case, the focus is Canadian policy. From Gierczak’s September 17, 2018 posting (Note: Links have been removed),

In Canada, companies need approval from Health Canada. But a 2004 law called the Assisted Human Reproduction Act (AHR Act) states that it’s a criminal offence “to alter the genome of a human cell, or in vitroembryo, that is capable of being transmitted to descendants”. The Actis so broadly written that Canadian scientists are prohibited from using the CRISPR-Cas9 technology on even somatic cells. Today, Canada is one of the few countries in the world where treating a disease with CRISPR-Cas9 is a crime.

On the other hand, some countries provide little regulatory oversight for editing either germ or somatic cells. In China, a company often only needs to satisfy the requirements of the local hospital where the treatment is being performed. And, if germ-cell editing goes wrong, there is little recourse for the future generations affected.

The AHR Act was introduced to regulate the use of reproductive technologies like in vitrofertilization and research related to cloning human embryos during the 1980s and 1990s. Today, we live in a time when medical science, and its role in Canadian society, is rapidly changing. CRISPR-Cas9 is a powerful tool, and there are aspects of the technology that aren’t well understood and could potentially put patients at risk if we move ahead too quickly. But the potential benefits are significant. Updated legislation that acknowledges both the risks and current realities of genomic engineering [emphasis mine] would relieve the current obstacles and support a path toward the introduction of safe new therapies.

Criminal ban on human gene-editing of inheritable cells (in Canada)

I had no idea there was a criminal ban on the practice until reading this January 2017 editorial by Bartha Maria Knoppers, Rosario Isasi, Timothy Caulfield, Erika Kleiderman, Patrick Bedford, Judy Illes, Ubaka Ogbogu, Vardit Ravitsky, & Michael Rudnicki for (Nature) npj Regenerative Medicine (Note: Links have been removed),

Driven by the rapid evolution of gene editing technologies, international policy is examining which regulatory models can address the ensuing scientific, socio-ethical and legal challenges for regenerative and personalised medicine.1 Emerging gene editing technologies, including the CRISPR/Cas9 2015 scientific breakthrough,2 are powerful, relatively inexpensive, accurate, and broadly accessible research tools.3 Moreover, they are being utilised throughout the world in a wide range of research initiatives with a clear eye on potential clinical applications. Considering the implications of human gene editing for selection, modification and enhancement, it is time to re-examine policy in Canada relevant to these important advances in the history of medicine and science, and the legislative and regulatory frameworks that govern them. Given the potential human reproductive applications of these technologies, careful consideration of these possibilities, as well as ethical and regulatory scrutiny must be a priority.4

With the advent of human embryonic stem cell research in 1978, the birth of Dolly (the cloned sheep) in 1996 and the Raelian cloning hoax in 2003, the environment surrounding the enactment of Canada’s 2004 Assisted Human Reproduction Act (AHRA) was the result of a decade of polarised debate,5 fuelled by dystopian and utopian visions for future applications. Rightly or not, this led to the AHRA prohibition on a wide range of activities, including the creation of embryos (s. 5(1)(b)) or chimeras (s. 5(1)(i)) for research and in vitro and in vivo germ line alterations (s. 5(1)(f)). Sanctions range from a fine (up to $500,000) to imprisonment (up to 10 years) (s. 60 AHRA).

In Canada, the criminal ban on gene editing appears clear, the Act states that “No person shall knowingly […] alter the genome of a cell of a human being or in vitro embryo such that the alteration is capable of being transmitted to descendants;” [emphases mine] (s. 5(1)(f) AHRA). This approach is not shared worldwide as other countries such as the United Kingdom, take a more regulatory approach to gene editing research.1 Indeed, as noted by the Law Reform Commission of Canada in 1982, criminal law should be ‘an instrument of last resort’ used solely for “conduct which is culpable, seriously harmful, and generally conceived of as deserving of punishment”.6 A criminal ban is a suboptimal policy tool for science as it is inflexible, stifles public debate, and hinders responsiveness to the evolving nature of science and societal attitudes.7 In contrast, a moratorium such as the self-imposed research moratorium on human germ line editing called for by scientists in December 20158 can at least allow for a time limited pause. But like bans, they may offer the illusion of finality and safety while halting research required to move forward and validate innovation.

On October 1st, 2016, Health Canada issued a Notice of Intent to develop regulations under the AHRA but this effort is limited to safety and payment issues (i.e. gamete donation). Today, there is a need for Canada to revisit the laws and policies that address the ethical, legal and social implications of human gene editing. The goal of such a critical move in Canada’s scientific and legal history would be a discussion of the right of Canadians to benefit from the advancement of science and its applications as promulgated in article 27 of the Universal Declaration of Human Rights9 and article 15(b) of the International Covenant on Economic, Social and Cultural Rights,10 which Canada has signed and ratified. Such an approach would further ensure the freedom of scientific endeavour both as a principle of a liberal democracy and as a social good, while allowing Canada to be engaged with the international scientific community.

Even though it’s a bit old, I still recommend reading the open access editorial in full, if you have the time.

One last thing abut the paper, the acknowledgements,

Sponsored by Canada’s Stem Cell Network, the Centre of Genomics and Policy of McGill University convened a ‘think tank’ on the future of human gene editing in Canada with legal and ethics experts as well as representatives and observers from government in Ottawa (August 31, 2016). The experts were Patrick Bedford, Janetta Bijl, Timothy Caulfield, Judy Illes, Rosario Isasi, Jonathan Kimmelman, Erika Kleiderman, Bartha Maria Knoppers, Eric Meslin, Cate Murray, Ubaka Ogbogu, Vardit Ravitsky, Michael Rudnicki, Stephen Strauss, Philip Welford, and Susan Zimmerman. The observers were Geneviève Dubois-Flynn, Danika Goosney, Peter Monette, Kyle Norrie, and Anthony Ridgway.

Competing interests

The authors declare no competing interests.

Both McGill and the Stem Cell Network pop up again. A November 8, 2017 article about the need for new Canadian gene-editing policies by Tom Blackwell for the National Post features some familiar names (Did someone have a budget for public relations and promotion?),

It’s one of the most exciting, and controversial, areas of health science today: new technology that can alter the genetic content of cells, potentially preventing inherited disease — or creating genetically enhanced humans.

But Canada is among the few countries in the world where working with the CRISPR gene-editing system on cells whose DNA can be passed down to future generations is a criminal offence, with penalties of up to 10 years in jail.

This week, one major science group announced it wants that changed, calling on the federal government to lift the prohibition and allow researchers to alter the genome of inheritable “germ” cells and embryos.

The potential of the technology is huge and the theoretical risks like eugenics or cloning are overplayed, argued a panel of the Stem Cell Network.

The step would be a “game-changer,” said Bartha Knoppers, a health-policy expert at McGill University, in a presentation to the annual Till & McCulloch Meetings of stem-cell and regenerative-medicine researchers [These meetings were originally known as the Stem Cell Network’s Annual General Meeting {AGM}]. [emphases mine]

“I’m completely against any modification of the human genome,” said the unidentified meeting attendee. “If you open this door, you won’t ever be able to close it again.”

If the ban is kept in place, however, Canadian scientists will fall further behind colleagues in other countries, say the experts behind the statement say; they argue possible abuses can be prevented with good ethical oversight.

“It’s a human-reproduction law, it was never meant to ban and slow down and restrict research,” said Vardit Ravitsky, a University of Montreal bioethicist who was part of the panel. “It’s a sort of historical accident … and now our hands are tied.”

There are fears, as well, that CRISPR could be used to create improved humans who are genetically programmed to have certain facial or other features, or that the editing could have harmful side effects. Regardless, none of it is happening in Canada, good or bad.

In fact, the Stem Cell Network panel is arguably skirting around the most contentious applications of the technology. It says it is asking the government merely to legalize research for its own sake on embryos and germ cells — those in eggs and sperm — not genetic editing of embryos used to actually get women pregnant.

The highlighted portions in the last two paragraphs of the excerpt were written one year prior to the claims by a Chinese scientist that he had run a clinical trial resulting in gene-edited twins, Lulu and Nana. (See my my November 28, 2018 posting for a comprehensive overview of the original furor). I have yet to publish a followup posting featuring the news that the CRISPR twins may have been ‘improved’ more extensively than originally realized. The initial reports about the twins focused on an illness-related reason (making them HIV ‘immune’) but made no mention of enhanced cognitive skills a side effect of eliminating the gene that would make them HIV ‘immune’. To date, the researcher has not made the bulk of his data available for an in-depth analysis to support his claim that he successfully gene-edited the twins. As well, there were apparently seven other pregnancies coming to term as part of the researcher’s clinical trial and there has been no news about those births.

Risk analysis innovation

Before moving onto the innovation of risk analysis, I want to focus a little more on at least one of the risks that gene-editing might present. Gierczak noted that CRISPR/Cas9 is “not perfect,” which acknowledges the truth but doesn’t convey all that much information.

While the terms ‘precision’ and ‘scissors’ are used frequently when describing the CRISPR technique, scientists actually mean that the technique is significantly ‘more precise’ than other techniques but they are not referencing an engineering level of precision. As for the ‘scissors’, it’s an analogy scientists like to use but in fact CRISPR is not as efficient and precise as a pair of scissors.

Michael Le Page in a July 16, 2018 article for New Scientist lays out some of the issues (Note: A link has been removed),

A study of CRIPSR suggests we shouldn’t rush into trying out CRISPR genome editing inside people’s bodies just yet. The technique can cause big deletions or rearrangements of DNA [emphasis mine], says Allan Bradley of the Wellcome Sanger Institute in the UK, meaning some therapies based on CRISPR may not be quite as safe as we thought.

The CRISPR genome editing technique is revolutionising biology, enabling us to create new varieties of plants and animals and develop treatments for a wide range of diseases.

The CRISPR Cas9 protein works by cutting the DNA of a cell in a specific place. When the cell repairs the damage, a few DNA letters get changed at this spot – an effect that can be exploited to disable genes.

At least, that’s how it is supposed to work. But in studies of mice and human cells, Bradley’s team has found that in around a fifth of cells, CRISPR causes deletions or rearrangements more than 100 DNA letters long. These surprising changes are sometimes thousands of letters long.

“I do believe the findings are robust,” says Gaetan Burgio of the Australian National University, an expert on CRISPR who has debunked previous studies questioning the method’s safety. “This is a well-performed study and fairly significant.”

I covered the Bradley paper and the concerns in a July 17, 2018 posting ‘The CRISPR ((clustered regularly interspaced short palindromic repeats)-CAS9 gene-editing technique may cause new genetic damage kerfuffle‘. (The ‘kerfufle’ was in reference to a report that the CRISPR market was affected by the publication of Bradley’s paper.)

Despite Health Canada not moving swiftly enough for some researchers, they have nonetheless managed to release an ‘outcome’ report about a consultation/analysis started in October 2016. Before getting to the consultation’s outcome, it’s interesting to look at how the consultation’s call for response was described (from Health Canada’s Toward a strengthened Assisted Human Reproduction Act ; A Consultation with Canadians on Key Policy Proposals webpage),

In October 2016, recognizing the need to strengthen the regulatory framework governing assisted human reproduction in Canada, Health Canada announced its intention to bring into force the dormant sections of the Assisted Human Reproduction Act  and to develop the necessary supporting regulations.

This consultation document provides an overview of the key policy proposals that will help inform the development of regulations to support bringing into force Section 10, Section 12 and Sections 45-58 of the Act. Specifically, the policy proposals describe the Department’s position on the following:

Section 10: Safety of Donor Sperm and Ova

  • Scope and application
  • Regulated parties and their regulatory obligations
  • Processing requirements, including donor suitability assessment
  • Record-keeping and traceability

Section 12: Reimbursement

  • Expenditures that may be reimbursed
  • Process for reimbursement
  • Creation and maintenance of records

Sections 45-58: Administration and Enforcement

  • Scope of the administration and enforcement framework
  • Role of inspectors designated under the Act

The purpose of the document is to provide Canadians with an opportunity to review the policy proposals and to provide feedback [emphasis mine] prior to the Department finalizing policy decisions and developing the regulations. In addition to requesting stakeholders’ general feedback on the policy proposals, the Department is also seeking input on specific questions, which are included throughout the document.

It took me a while to find the relevant section (in particular, take note of ‘Federal Regulatory Oversight’),

3.2. AHR in Canada Today

Today, an increasing number of Canadians are turning to AHR technologies to grow or build their families. A 2012 Canadian studyFootnote 1 found that infertility is on the rise in Canada, with roughly 16% of heterosexual couples experiencing infertility. In addition to rising infertility, the trend of delaying marriage and parenthood, scientific advances in cryopreserving ova, and the increasing use of AHR by LGBTQ2 couples and single parents to build a family are all contributing to an increase in the use of AHR technologies.

The growing use of reproductive technologies by Canadians to help build their families underscores the need to strengthen the AHR Act. While the approach to regulating AHR varies from country to country, Health Canada has considered international best practices and the need for regulatory alignment when developing the proposed policies set out in this document. …

3.2.1 Federal Regulatory Oversight

Although the scope of the AHR Act was significantly reduced in 2012 and some of the remaining sections have not yet been brought into force, there are many important sections of the Act that are currently administered and enforced by Health Canada, as summarized generally below:

Section 5: Prohibited Scientific and Research Procedures
Section 5 prohibits certain types of scientific research and clinical procedures that are deemed unacceptable, including: human cloning, the creation of an embryo for non-reproductive purposes, maintaining an embryo outside the human body beyond the fourteenth day, sex selection for non-medical reasons, altering the genome in a way that could be transmitted to descendants, and creating a chimera or a hybrid. [emphasis mine]

….

It almost seems as if the they were hiding the section that broached the human gene-editing question. It doesn’t seem to have worked as it appears, there are some very motivated parties determined to reframe the discussion. Health Canada’s ‘outocme’ report, published March 2019, What we heard: A summary of scanning and consultations on what’s next for health product regulation reflects the success of those efforts,

1.0 Introduction and Context

Scientific and technological advances are accelerating the pace of innovation. These advances are increasingly leading to the development of health products that are better able to predict, define, treat, and even cure human diseases. Globally, many factors are driving regulators to think about how to enable health innovation. To this end, Health Canada has been expanding beyond existing partnerships and engaging both domestically and internationally. This expanding landscape of products and services comes with a range of new challenges and opportunities.

In keeping up to date with emerging technologies and working collaboratively through strategic partnerships, Health Canada seeks to position itself as a regulator at the forefront of health innovation. Following the targeted sectoral review of the Health and Biosciences Sector Regulatory Review consultation by the Treasury Board Secretariat, Health Canada held a number of targeted meetings with a broad range of stakeholders.

This report outlines the methodologies used to look ahead at the emerging health technology environment, [emphasis mine] the potential areas of focus that resulted, and the key findings from consultations.

… the Department identified the following key drivers that are expected to shape the future of health innovation:

  1. The use of “big data” to inform decision-making: Health systems are generating more data, and becoming reliant on this data. The increasing accuracy, types, and volume of data available in real time enable automation and machine learning that can forecast activity, behaviour, or trends to support decision-making.
  2. Greater demand for citizen agency: Canadians increasingly want and have access to more information, resources, options, and platforms to manage their own health (e.g., mobile apps, direct-to-consumer services, decentralization of care).
  3. Increased precision and personalization in health care delivery: Diagnostic tools and therapies are increasingly able to target individual patients with customized therapies (e.g., individual gene therapy).
  4. Increased product complexity: Increasingly complex products do not fit well within conventional product classifications and standards (e.g., 3D printing).
  5. Evolving methods for production and distribution: In some cases, manufacturers and supply chains are becoming more distributed, challenging the current framework governing production and distribution of health products.
  6. The ways in which evidence is collected and used are changing: The processes around new drug innovation, research and development, and designing clinical trials are evolving in ways that are more flexible and adaptive.

With these key drivers in mind, the Department selected the following six emerging technologies for further investigation to better understand how the health product space is evolving:

  1. Artificial intelligence, including activities such as machine learning, neural networks, natural language processing, and robotics.
  2. Advanced cell therapies, such as individualized cell therapies tailor-made to address specific patient needs.
  3. Big data, from sources such as sensors, genetic information, and social media that are increasingly used to inform patient and health care practitioner decisions.
  4. 3D printing of health products (e.g., implants, prosthetics, cells, tissues).
  5. New ways of delivering drugs that bring together different product lines and methods (e.g., nano-carriers, implantable devices).
  6. Gene editing, including individualized gene therapies that can assist in preventing and treating certain diseases.

Next, to test the drivers identified and further investigate emerging technologies, the Department consulted key organizations and thought leaders across the country with expertise in health innovation. To this end, Health Canada held seven workshops with over 140 representatives from industry associations, small-to-medium sized enterprises and start-ups, larger multinational companies, investors, researchers, and clinicians in Ottawa, Toronto, Montreal, and Vancouver. [emphases mine]

The ‘outocme’ report, ‘What we heard …’, is well worth reading in its entirety; it’s about 9 pp.

I have one comment, ‘stakeholders’ don’t seem to include anyone who isn’t “from industry associations, small-to-medium sized enterprises and start-ups, larger multinational companies, investors, researchers, and clinician” or from “Ottawa, Toronto, Montreal, and Vancouver.” Aren’t the rest of us stakeholders?

Innovating risk analysis

This line in the report caught my eye (from Health Canada’s Toward a strengthened Assisted Human Reproduction Act ; A Consultation with Canadians on Key Policy Proposals webpage),

There is increasing need to enable innovation in a flexible, risk-based way, with appropriate oversight to ensure safety, quality, and efficacy. [emphases mine]

It reminded me of the 2019 federal budget (from my March 22, 2019 posting). One comment before proceeding, regulation and risk are tightly linked and, so, by innovating regulation they are by exttension alos innovating risk analysis,

… Budget 2019 introduces the first three “Regulatory Roadmaps” to specifically address stakeholder issues and irritants in these sectors, informed by over 140 responses [emphasis mine] from businesses and Canadians across the country, as well as recommendations from the Economic Strategy Tables.

Introducing Regulatory Roadmaps

These Roadmaps lay out the Government’s plans to modernize regulatory frameworks, without compromising our strong health, safety, and environmental protections. They contain proposals for legislative and regulatory amendments as well as novel regulatory approaches to accommodate emerging technologies, including the use of regulatory sandboxes and pilot projects—better aligning our regulatory frameworks with industry realities.

Budget 2019 proposes the necessary funding and legislative revisions so that regulatory departments and agencies can move forward on the Roadmaps, including providing the Canadian Food Inspection Agency, Health Canada and Transport Canada with up to $219.1 million over five years, starting in 2019–20, (with $0.5 million in remaining amortization), and $3.1 million per year on an ongoing basis.

In the coming weeks, the Government will be releasing the full Regulatory Roadmaps for each of the reviews, as well as timelines for enacting specific initiatives, which can be grouped in the following three main areas:

What Is a Regulatory Sandbox? Regulatory sandboxes are controlled “safe spaces” in which innovative products, services, business models and delivery mechanisms can be tested without immediately being subject to all of the regulatory requirements.
– European Banking Authority, 2017

Establishing a regulatory sandbox for new and innovative medical products
The regulatory approval system has not kept up with new medical technologies and processes. Health Canada proposes to modernize regulations to put in place a regulatory sandbox for new and innovative products, such as tissues developed through 3D printing, artificial intelligence, and gene therapies targeted to specific individuals. [emphasis mine]

Modernizing the regulation of clinical trials
Industry and academics have expressed concerns that regulations related to clinical trials are overly prescriptive and inconsistent. Health Canada proposes to implement a risk-based approach [emphasis mine] to clinical trials to reduce costs to industry and academics by removing unnecessary requirements for low-risk drugs and trials. The regulations will also provide the agri-food industry with the ability to carry out clinical trials within Canada on products such as food for special dietary use and novel foods.

Does the government always get 140 responses from a consultation process? Moving on, I agree with finding new approaches to regulatory processes and oversight and, by extension, new approaches to risk analysis.

Earlier in this post, I asked if someone had a budget for public relations/promotion. I wasn’t joking. My March 22, 2019 posting also included these line items in the proposed 2019 budget,

Budget 2019 proposes to make additional investments in support of the following organizations:
Stem Cell Network: Stem cell research—pioneered by two Canadians in the 1960s [James Till and Ernest McCulloch]—holds great promise for new therapies and medical treatments for respiratory and heart diseases, spinal cord injury, cancer, and many other diseases and disorders. The Stem Cell Network is a national not-for-profit organization that helps translate stem cell research into clinical applications and commercial products. To support this important work and foster Canada’s leadership in stem cell research, Budget 2019 proposes to provide the Stem Cell Network with renewed funding of $18 million over three years, starting in 2019–20.

Genome Canada: The insights derived from genomics—the study of the entire genetic information of living things encoded in their DNA and related molecules and proteins—hold the potential for breakthroughs that can improve the lives of Canadians and drive innovation and economic growth. Genome Canada is a not-for-profit organization dedicated to advancing genomics science and technology in order to create economic and social benefits for Canadians. To support Genome Canada’s operations, Budget 2019 proposes to provide Genome Canada with $100.5 million over five years, starting in 2020–21. This investment will also enable Genome Canada to launch new large-scale research competitions and projects, in collaboration with external partners, ensuring that Canada’s research community continues to have access to the resources needed to make transformative scientific breakthroughs and translate these discoveries into real-world applications.

Years ago, I managed to find a webpage with all of the proposals various organizations were submitting to a government budget committee. It was eye-opening. You can tell which organizations were able to hire someone who knew the current government buzzwords and the things that a government bureaucrat would want to hear and the organizations that didn’t.

Of course, if the government of the day is adamantly against or uninterested, no amount of persusasion will work to get your organization more money in the budget.

Finally

Reluctantly, I am inclined to explore the topic of emerging technologies such as gene-editing not only in the field of agriculture (for gene-editing of plants, fish, and animals see my November 28, 2018 posting) but also with humans. At the very least, it needs to be discussed whether we choose to participate or not.

If you are interested in the arguments against changing Canada’s prohibition against gene-editing of humans, there’s an Ocotber 2, 2017 posting on Impact Ethics by Françoise Baylis, Professor and Canada Research Chair in Bioethics and Philosophy at Dalhousie University, and Alana Cattapan, Johnson Shoyama Graduate School of Public Policy at the University of Saskatchewan, which makes some compelling arguments. Of course, it was written before the CRISPR twins (my November 28, 2018 posting).

Recaliing CRISPR Therapeutics (mentioned by Gierczak), the company received permission to run clinical trials in the US in October 2018 after the FDA (US Food and Drug Administration) lifted an earlier ban on their trials according to an Oct. 10, 2018 article by Frank Vinhuan for exome,

The partners also noted that their therapy is making progress outside of the U.S. They announced that they have received regulatory clearance in “multiple countries” to begin tests of the experimental treatment in both sickle cell disease and beta thalassemia, …

It seems to me that the quotes around “multiple countries” are meant to suggest doubt of some kind. Generally speaking, company representatives make those kinds of generalizations when they’re trying to pump up their copy. E.g., 50% increase in attendance  but no whole numbers to tell you what that means. It could mean two people attended the first year and then brought a friend the next year or 100 people attended and the next year there were 150.

Despite attempts to declare personalized medicine as having arrived, I think everything is still in flux with no preordained outcome. The future has yet to be determined but it will be and I , for one, would like to have some say in the matter.

June 4, 2018 talk in Vancouver (Canada): Genetically-Engineered Food: Facts, Ethical Considerations and World Hunger

ARPICO (Society of Italian Researchers and Professionals in Western Canada) is hosting a talk on the topic of genetically modified food. Here’s more from their May 20, 2018 announcement (received via email),

Our third speaking event of the year has been scheduled for Monday, June 4th, 2018 at the Italian Cultural Centre – Museum & Art Gallery. Marie-Claude Fortin’s talk will discuss food systems derived from biotechnology (often referred to as GMO) and their comparison with traditional farming processes, both technical and ethical. You can read a summary of Marie-Claude Fortin’s lecture as well as her short professional biography at the bottom of this message.

Ahead of the speaking event, ARPICO will be holding its 2018 Annual General Meeting in the same location. We encourage everyone to participate in the AGM, have their say on ARPICO’s matters and possibly volunteer for the Board of Directors.

We look forward to seeing everyone there.

Please register for the event by visiting the EventBrite link or RSVPing to info@arpico.ca.

The evening agenda is as follows:

6:00pm to 6:45pm – Annual General Meeting
7:00 pm – Lecture by Marie-Claude Fortin
~8:00 pm – Q & A Period
Mingling & Refreshments until about 9:45 pm

If you have not yet RSVP’d, please do so on our EventBrite page.

Further details are also available at arpico.ca, our facebook page, and Eventbrite.

Genetically-Engineered Food: Facts, Ethical Considerations and World Hunger

In this lecture we will explore a part of our food system, which has received much press, but which consumers still misunderstand: food derived from biotechnology often referred to as genetically modified organisms. We will be learning about the types of plants and animals which are genetically engineered and part of our everyday food system and the reasons for which they have been transformed genetically. We will be looking at the issue from several different angles. You are encouraged to approach the topic with an open mind, and learn how the technology is being used. We will start by understanding the differences between traditional plant breeding, conventional plant breeding, transgenic technology and genome editing. The latter two processes are considered genetic engineering technologies but all of them constitute a continuum of techniques employed to improve domestic plants and animals. We will then go over the ethical paradigms related to genetically engineered food represented by the European and North American points of view. Finally, we will discuss the strengths and weaknesses associated with genetic engineering as a tool to solve world hunger.

Marie-Claude Fortin is a former Research Scientist with Agriculture and Agri-Food Canada, Associate Editor with Crop Science Society of America, Board Member of the Soil and Water Conservation Society and Adjunct Professor at the University of British Columbia (UBC) and currently responsible for the shared research infrastructure portfolio at the UBC Vice-President Research & Innovation Office. Her main areas of research expertise are crop and soil sciences with special interests in measuring and modeling crop development and various processes on agricultural land: water and nitrogen fertilizer flow through the soil profile, emissions of greenhouse gases and soil physical properties. Her research shows that sustainable crop management practices result in soil environments, which are conducive to resilient crop production and organic matter buildup, which is the process of storing carbon in soils, a most important process in this era of climate change. For the past 18 years, Marie-Claude has been teaching food systems courses at UBC [University of British Columbia], emphasizing impacts of decisions made at the corporate, national and local levels on the economic, environmental and social sustainability of the food system, including impacts of organic and industrial agriculture and adoption of genetically engineered crops and animals, on farmers and consumers.

WHEN (AGM): Monday, June 4th, 2018 at 6:00pm (doors open at 5:50pm)

WHEN (EVENT): Monday, June 4th, 2018 at 7:00pm (doors open at 6:45pm)

WHERE: Italian Cultural Centre – Museum & Art Gallery – 3075 Slocan St, Vancouver, BC, V5M 3E4

RSVP: Please RSVP at EventBrite (https://gmofoods.eventbrite.ca/) or email info@arpico.ca

Tickets are Needed

Tickets are FREE, but all individuals are requested to obtain “free-admission” tickets on EventBrite site due to limited seating at the venue. Organizers need accurate registration numbers to manage wait lists and prepare name tags.

All ARPICO events are 100% staffed by volunteer organizers and helpers, however, room rental, stationery, and guest refreshments are costs incurred and underwritten by members of ARPICO. Therefore to be fair, all audience participants are asked to donate to the best of their ability at the door or via EventBrite to “help” defray costs of the event.

FAQs

Where can I contact the organizer with any questions? info@arpico.ca

Do I have to bring my printed ticket to the event? No, you do not. Your name will be on our Registration List at the Check-in Desk.

Is my registration/ticket transferrable? If you are unable to attend, another person may use your ticket. Please send us an email at info@arpico.ca of this substitution to correct our audience Registration List and to prepare guest name tags.

Can I update my registration information? Yes. If you have any questions, contact us at info@arpico.ca

I am having trouble using EventBrite and cannot reserve my ticket(s). Can someone at ARPICO help me with my ticket reservation? Of course, simply send your ticket request to us at info@arpico.ca so we help you.

We look forward to seeing you there.
www.arpico.ca

I wonder if they’re going to be discussing AquAdvantage salmon, which was first mentioned here in a Dec. 4, 2015 post (scroll down about 40% of the way), again, in a May 20, 2016 posting (AquAdvantage salmon (genetically modified) approved for consumption in Canada), and, most recently, in a Sept. 13, 2017 posting where I was critiquing a couple of books (scroll down to the ‘Fish’ subtitle). Allegedly the fish were allegedly sold in the Canadian market,

Since the 2016 approval, AquAdvantage salmon, 4.5M tonnes has been sold in Canada according to an Aug. 8, 2017 article by Sima Shakeri for Huffington Post (Note: Links have been removed),

After decades of trying to get approval by in North America, genetically modified Atlantic salmon has been sold to consumers in Canada.

AquaBounty Technologies, an American company that produces the Atlantic salmon, confirmed it had sold 4.5 tonnes of the modified fish on August 4 [2017], the Scientific American reported.

The fish have been engineered with a growth hormone gene from Chinook salmon to grow faster than regular salmon and require less food. They take about 18 months to reach market size, which is much quicker than the 30 months or so for conventional salmon.

The Washington Post wrote AquaBounty’s salmon also contains a gene from the ocean pout that makes the salmon produce the growth hormone gene all-year-round.

The company produces the eggs in a facility in P.E.I., which is currently being expanded, and then they’re shipped to Panama where the fish are raised.

Health Canada assessed the AquAdvantage salmon and concluded it “did not pose a greater risk to human health than salmon currently available on the Canadian market,” and that it would have no impact on allergies nor a difference in nutritional value compared to other farmed salmon.

Because of that, the AquAdvantage product is not required to be specially labelled as genetically modified, and is up to the discretion of retailers.

As for gene editing, I don’t follow everything in that area of endeavour but I have (more or less) kept track of CRISPR ((clustered regularly interspaced short palindromic repeat). Just use CRISPR as the search term for the blog search function to find what’s here.

This looks to be a very interesting talk and good for ARPICO for tackling a ‘difficult’ topic. I hope they have a lively, convivial, and open discussion.

Why don’t you CRISPR yourself?

It must have been quite the conference. Josiah Zayner plunged a needle into himself and claimed to have changed his DNA (deoxyribonucleic acid) while giving his talk. (*Segue: There is some Canadian content if you keep reading.*) From an Oct. 10, 2017 article by Adele Peters for Fast Company (Note: A link has been removed),

“What we’ve got here is some DNA, and this is a syringe,” Josiah Zayner tells a room full of synthetic biologists and other researchers. He fills the needle and plunges it into his skin. “This will modify my muscle genes and give me bigger muscles.”

Zayner, a biohacker–basically meaning he experiments with biology in a DIY lab rather than a traditional one–was giving a talk called “A Step-by-Step Guide to Genetically Modifying Yourself With CRISPR” at the SynBioBeta conference in San Francisco, where other presentations featured academics in suits and the young CEOs of typical biotech startups. Unlike the others, he started his workshop by handing out shots of scotch and a booklet explaining the basics of DIY [do-it-yourwelf] genome engineering.

If you want to genetically modify yourself, it turns out, it’s not necessarily complicated. As he offered samples in small baggies to the crowd, Zayner explained that it took him about five minutes to make the DNA that he brought to the presentation. The vial held Cas9, an enzyme that snips DNA at a particular location targeted by guide RNA, in the gene-editing system known as CRISPR. In this case, it was designed to knock out the myostatin gene, which produces a hormone that limits muscle growth and lets muscles atrophy. In a study in China, dogs with the edited gene had double the muscle mass of normal dogs. If anyone in the audience wanted to try it, they could take a vial home and inject it later. Even rubbing it on skin, Zayner said, would have some effect on cells, albeit limited.

Peters goes on to note that Zayner has a PhD in molecular biology and biophysics and worked for NASA (US National Aeronautics and Space Administration). Zayner’s Wikipedia entry fills in a few more details (Note: Links have been removed),

Zayner graduated from the University of Chicago with a Ph.D. in biophysics in 2013. He then spent two years as a researcher at NASA’s Ames Research Center,[2] where he worked on Martian colony habitat design. While at the agency, Zayner also analyzed speech patterns in online chat, Twitter, and books, and found that language on Twitter and online chat is closer to how people talk than to how they write.[3] Zayner found NASA’s scientific work less innovative than he expected, and upon leaving in January 2016, he launched a crowdfunding campaign to provide CRISPR kits to let the general public experiment with editing bacterial DNA. He also continued his grad school business, The ODIN, which sells kits to let the general public experiment at home. As of May 2016, The ODIN had four employees and operates out of Zayner’s garage.[2]

He refers to himself as a biohacker and believes in the importance in letting the general public participate in scientific experimentation, rather than leaving it segregated to labs.[2][4][1] Zayner found the biohacking community exclusive and hierarchical, particularly in the types of people who decide what is “safe”. He hopes that his projects can let even more people experiment in their homes. Other scientists responded that biohacking is inherently privileged, as it requires leisure time and money, and that deviance from the safety rules of concern would lead to even harsher regulations for all.[5] Zayner’s public CRISPR kit campaign coincided with wider scrutiny over genetic modification. Zayner maintained that these fears were based on misunderstandings of the product, as genetic experiments on yeast and bacteria cannot produce a viral epidemic.[6][7] In April 2015, Zayner ran a hoax on Craigslist to raise awareness about the future potential of forgery in forensics genetics testing.[8]

In February 2016, Zayner performed a full body microbiome transplant on himself, including a fecal transplant, to experiment with microbiome engineering and see if he could cure himself from gastrointestinal and other health issues. The microbiome from the donors feces successfully transplanted in Zayner’s gut according to DNA sequencing done on samples.[2] This experiment was documented by filmmakers Kate McLean and Mario Furloni and turned into the short documentary film Gut Hack.[9]

In December 2016, Zayner created a fluorescent beer by engineering yeast to contain the green fluorescent protein from jellyfish. Zayner’s company, The ODIN, released kits to allow people to create their own engineered fluorescent yeast and this was met with some controversy as the FDA declared the green fluorescent protein can be seen as a color additive.[10] Zayner, views the kit as a way that individual can use genetic engineering to create things in their everyday life.[11]

I found the video for Zayner’s now completed crowdfunding campaign,

I also found The ODIN website (mentioned in the Wikipedia essay) where they claim to be selling various gene editing and gene engineering kits including the CRISPR editing kits mentioned in Peters’ article,

In 2016, he [Zayner] sold $200,000 worth of products, including a kit for yeast that can be used to brew glowing bioluminescent beer, a kit to discover antibiotics at home, and a full home lab that’s roughly the cost of a MacBook Pro. In 2017, he expects to double sales. Many kits are simple, and most buyers probably aren’t using the supplies to attempt to engineer themselves (many kits go to classrooms). But Zayner also hopes that as people using the kits gain genetic literacy, they experiment in wilder ways.

Zayner sells a full home biohacking lab that’s roughly the cost of a MacBook Pro. [Photo: The ODIN]

He questions whether traditional research methods, like randomized controlled trials, are the only way to make discoveries, pointing out that in newer personalized medicine (such as immunotherapy for cancer, which is personalized for each patient), a sample size of one person makes sense. At his workshop, he argued that people should have the choice to self-experiment if they want to; we also change our DNA when we drink alcohol or smoke cigarettes or breathe in dirty city air. Other society-sanctioned activities are more dangerous. “We sacrifice maybe a million people a year to the car gods,” he said. “If you ask someone, ‘Would you get rid of cars?’–no.” …

US researchers both conventional and DIY types such as Zayner are not the only ones who are editing genes. The Chinese study mentioned in Peters’ article was written up in an Oct. 19, 2015 article by Antonio Regalado for the MIT [Massachusetts Institute of Technology] Technology Review (Note: Links have been removed),

Scientists in China say they are the first to use gene editing to produce customized dogs. They created a beagle with double the amount of muscle mass by deleting a gene called myostatin.

The dogs have “more muscles and are expected to have stronger running ability, which is good for hunting, police (military) applications,” Liangxue Lai, a researcher with the Key Laboratory of Regenerative Biology at the Guangzhou Institutes of Biomedicine and Health, said in an e-mail.

Lai and 28 colleagues reported their results last week in the Journal of Molecular Cell Biology, saying they intend to create dogs with other DNA mutations, including ones that mimic human diseases such as Parkinson’s and muscular dystrophy. “The goal of the research is to explore an approach to the generation of new disease dog models for biomedical research,” says Lai. “Dogs are very close to humans in terms of metabolic, physiological, and anatomical characteristics.”

Lai said his group had no plans breed to breed the extra-muscular beagles as pets. Other teams, however, could move quickly to commercialize gene-altered dogs, potentially editing their DNA to change their size, enhance their intelligence, or correct genetic illnesses. A different Chinese Institute, BGI, said in September it had begun selling miniature pigs, created via gene editing, for $1,600 each as novelty pets.

People have been influencing the genetics of dogs for millennia. By at least 36,000 years ago, early humans had already started to tame wolves and shape the companions we have today. Charles Darwin frequently cited dog breeding in The Origin of Species to demonstrate how evolution gradually occurs by a process of selection. With CRISPR, however, evolution is no longer gradual or subject to chance. It is immediate and under human control.

It is precisely that power that is stirring wide debate and concern over CRISPR. Yet at least some researchers think that gene-edited dogs could put a furry, friendly face on the technology. In an interview this month, George Church, a professor at Harvard University who leads a large effort to employ CRISPR editing, said he thinks it will be possible to augment dogs by using DNA edits to make them live longer or simply make them smarter.

Church said he also believed the alteration of dogs and other large animals could open a path to eventual gene editing of people. “Germline editing of pigs or dogs offers a line into it,” he said. “People might say, ‘Hey, it works.’ ”

In the meantime, Zayner’s ideas are certainly thought provoking. I’m not endorsing either his products or his ideas but it should be noted that early science pioneers such as Humphrey Davy and others experimented on themselves. For anyone unfamiliar with Davy, (from the Humphrey Davy Wikipedia entry; Note: Links have been removed),

Sir Humphry Davy, 1st Baronet PRS MRIA FGS (17 December 1778 – 29 May 1829) was a Cornish chemist and inventor,[1] who is best remembered today for isolating a series of substances for the first time: potassium and sodium in 1807 and calcium, strontium, barium, magnesium and boron the following year, as well as discovering the elemental nature of chlorine and iodine. He also studied the forces involved in these separations, inventing the new field of electrochemistry. Berzelius called Davy’s 1806 Bakerian Lecture On Some Chemical Agencies of Electricity[2] “one of the best memoirs which has ever enriched the theory of chemistry.”[3] He was a Baronet, President of the Royal Society (PRS), Member of the Royal Irish Academy (MRIA), and Fellow of the Geological Society (FGS). He also invented the Davy lamp and a very early form of incandescent light bulb.

Canadian content*

A Nov. 11, 2017 posting on the Canadian Broadcasting Corporation’s (CBC) Quirks and Quarks blog notes that self-experimentation has a long history and goes on to describe Zayner’s and others biohacking exploits before describing the legality of biohacking in Canada,

With biohackers entering into the space traditionally held by scientists and clinicians, it begs questions. Professor Timothy Caulfield, a Canada research chair in health, law and policy at the University of Alberta, says when he hears of somebody giving themselves biohacked gene therapy, he wonders: “Is this legal? Is this safe? And if it’s not safe, is there anything that we can do about regulating it? And to be honest with you that’s a tough question and I think it’s an open question.”

In Canada, Caulfield says, Health Canada focuses on products. “You have to have something that you are going to regulate or you have to have something that’s making health claims. So if there is a product that is saying I can cure X, Y, or Z, Health Canada can say, ‘Well let’s make sure the science really backs up that claim.’ The problem with these do-it-yourself approaches is there isn’t really a product. You know these people are experimenting on themselves with something that may or may not be designed for health purposes.”

According to Caufield, if you could buy a gene therapy kit that was being marketed to you to biohack yourself, that would be different. “Health Canada could jump in. But right here that’s not the case,” he says.

There are places in the world that do regulate biohacking, says Caulfield. “Germany, for example, they have specific laws for it. And here in Canada we do have a regulatory framework that says that you cannot do gene therapy that will alter the germ line. In other words, you can’t do gene therapy or any kind of genetic editing that will create a change that you will pass on to your offspring. So that would be illegal, but that’s not what’s happening here. And I don’t think there’s a regulatory framework that adequately captures it.”

Infectious disease and policy experts aren’t that concerned yet about the possibility of a biohacker unleashing a genetically modified super germ into the population.

“I think in the future that could be a problem,”says Caulfield, “but this isn’t something that would be easy to do in your garage. I think it’s complicated science. But having said that, the science is moving quickly. We need to think about how we are going to control the potential harms.”

You can find out more about the ‘wild’ people (mostly men) of early science in Richard Holmes’ 2008 book, The Age of Wonder: How the Romantic Generation Discovered the Beauty and Terror of Science.

Finally, should you be interested in connecting with synthetic biology enthusiasts, entrepreneurs, and others, SynBioBeta is more than a conference; it’s also an activity hub.

ETA January 25, 2018 (five minutes later): There are some CRISPR/CAS9 events taking place in Toronto, Canada on January 24 and 25, 2018. One is a workshop with Portuguese artist, Marta de Menezes, and the other is a panel discussion. See my January 10, 2018 posting for more details.

*’Segue: There is some Canadian content if you keep reading.’ and ‘Canadian content’ added January 25, 2018 six minutes after first publication.

ETA February 20, 2018: Sarah Zhang’s Feb. 20, 2018 article for The Atlantic revisits Josiah Zayner’s decision to inject himself with CRISPR,

When Josiah Zayner watched a biotech CEO drop his pants at a biohacking conference and inject himself with an untested herpes treatment, he realized things had gone off the rails.

Zayner is no stranger to stunts in biohacking—loosely defined as experiments, often on the self, that take place outside of traditional lab spaces. You might say he invented their latest incarnation: He’s sterilized his body to “transplant” his entire microbiome in front of a reporter. He’s squabbled with the FDA about selling a kit to make glow-in-the-dark beer. He’s extensively documented attempts to genetically engineer the color of his skin. And most notoriously, he injected his arm with DNA encoding for CRISPR that could theoretically enhance his muscles—in between taking swigs of Scotch at a live-streamed event during an October conference. (Experts say—and even Zayner himself in the live-stream conceded—it’s unlikely to work.)

So when Zayner saw Ascendance Biomedical’s CEO injecting himself on a live-stream earlier this month, you might say there was an uneasy flicker of recognition.

“Honestly, I kind of blame myself,” Zayner told me recently. He’s been in a soul-searching mood; he recently had a kid and the backlash to the CRISPR stunt in October [2017] had been getting to him. “There’s no doubt in my mind that somebody is going to end up hurt eventually,” he said.

Yup, it’s one of the reasons for rules; people take things too far. The trick is figuring out how to achieve balance between risk taking and recklessness.

3D bioprinting: a conference about the latest trends (May 3 – 5, 2017 at the University of British Columbia, Vancouver)

The University of British Columbia’s (UBC) Peter Wall Institute for Advanced Studies (PWIAS) is hosting along with local biotech firm, Aspect Biosystems, a May 3 -5, 2017 international research roundtable known as ‘Printing the Future of Therapeutics in 3D‘.

A May 1, 2017 UBC news release (received via email) offers some insight into the field of bioprinting from one of the roundtable organizers,

This week, global experts will gather [4] at the University of British
Columbia to discuss the latest trends in 3D bioprinting—a technology
used to create living tissues and organs.

In this Q&A, UBC chemical and biological engineering professor
Vikramaditya Yadav [5], who is also with the Regenerative Medicine
Cluster Initiative in B.C., explains how bioprinting could potentially
transform healthcare and drug development, and highlights Canadian
innovations in this field.

WHY IS 3D BIOPRINTING SIGNIFICANT?

Bioprinted tissues or organs could allow scientists to predict
beforehand how a drug will interact within the body. For every
life-saving therapeutic drug that makes its way into our medicine
cabinets, Health Canada blocks the entry of nine drugs because they are
proven unsafe or ineffective. Eliminating poor-quality drug candidates
to reduce development costs—and therefore the cost to consumers—has
never been more urgent.

In Canada alone, nearly 4,500 individuals are waiting to be matched with
organ donors. If and when bioprinters evolve to the point where they can
manufacture implantable organs, the concept of an organ transplant
waiting list would cease to exist. And bioprinted tissues and organs
from a patient’s own healthy cells could potentially reduce the risk
of transplant rejection and related challenges.

HOW IS THIS TECHNOLOGY CURRENTLY BEING USED?

Skin, cartilage and bone, and blood vessels are some of the tissue types
that have been successfully constructed using bioprinting. Two of the
most active players are the Wake Forest Institute for Regenerative
Medicine in North Carolina, which reports that its bioprinters can make
enough replacement skin to cover a burn with 10 times less healthy
tissue than is usually needed, and California-based Organovo, which
makes its kidney and liver tissue commercially available to
pharmaceutical companies for drug testing.

Beyond medicine, bioprinting has already been commercialized to print
meat and artificial leather. It’s been estimated that the global
bioprinting market will hit $2 billion by 2021.

HOW IS CANADA INVOLVED IN THIS FIELD?

Canada is home to some of the most innovative research clusters and
start-up companies in the field. The UBC spin-off Aspect Biosystems [6]
has pioneered a bioprinting paradigm that rapidly prints on-demand
tissues. It has successfully generated tissues found in human lungs.

Many initiatives at Canadian universities are laying strong foundations
for the translation of bioprinting and tissue engineering into
mainstream medical technologies. These include the Regenerative Medicine
Cluster Initiative in B.C., which is headed by UBC, and the University
of Toronto’s Institute of Biomaterials and Biomedical Engineering.

WHAT ETHICAL ISSUES DOES BIOPRINTING CREATE?

There are concerns about the quality of the printed tissues. It’s
important to note that the U.S. Food and Drug Administration and Health
Canada are dedicating entire divisions to regulation of biomanufactured
products and biomedical devices, and the FDA also has a special division
that focuses on regulation of additive manufacturing – another name
for 3D printing.

These regulatory bodies have an impressive track record that should
assuage concerns about the marketing of substandard tissue. But cost and
pricing are arguably much more complex issues.

Some ethicists have also raised questions about whether society is not
too far away from creating Replicants, à la _Blade Runner_. The idea is
fascinating, scary and ethically grey. In theory, if one could replace
the extracellular matrix of bones and muscles with a stronger substitute
and use cells that are viable for longer, it is not too far-fetched to
create bones or muscles that are stronger and more durable than their
natural counterparts.

WILL DOCTORS BE PRINTING REPLACEMENT BODY PARTS IN 20 YEARS’ TIME?

This is still some way off. Optimistically, patients could see the
technology in certain clinical environments within the next decade.
However, some technical challenges must be addressed in order for this
to occur, beginning with faithful replication of the correct 3D
architecture and vascularity of tissues and organs. The bioprinters
themselves need to be improved in order to increase cell viability after
printing.

These developments are happening as we speak. Regulation, though, will
be the biggest challenge for the field in the coming years.

There are some events open to the public (from the international research roundtable homepage),

OPEN EVENTS

You’re invited to attend the open events associated with Printing the Future of Therapeutics in 3D.

Café Scientifique

Thursday, May 4, 2017
Telus World of Science
5:30 – 8:00pm [all tickets have been claimed as of May 2, 2017 at 3:15 pm PT]

3D Bioprinting: Shaping the Future of Health

Imagine a world where drugs are developed without the use of animals, where doctors know how a patient will react to a drug before prescribing it and where patients can have a replacement organ 3D-printed using their own cells, without dealing with long donor waiting lists or organ rejection. 3D bioprinting could enable this world. Join us for lively discussion and dessert as experts in the field discuss the exciting potential of 3D bioprinting and the ethical issues raised when you can print human tissues on demand. This is also a rare opportunity to see a bioprinter live in action!

Open Session

Friday, May 5, 2017
Peter Wall Institute for Advanced Studies
2:00 – 7:00pm

A Scientific Discussion on the Promise of 3D Bioprinting

The medical industry is struggling to keep our ageing population healthy. Developing effective and safe drugs is too expensive and time-consuming to continue unchanged. We cannot meet the current demand for transplant organs, and people are dying on the donor waiting list every day.  We invite you to join an open session where four of the most influential academic and industry professionals in the field discuss how 3D bioprinting is being used to shape the future of health and what ethical challenges may be involved if you are able to print your own organs.

ROUNDTABLE INFORMATION

The University of British Columbia and the award-winning bioprinting company Aspect Biosystems, are proud to be co-organizing the first “Printing the Future of Therapeutics in 3D” International Research Roundtable. This event will congregate global leaders in tissue engineering research and pharmaceutical industry experts to discuss the rapidly emerging and potentially game-changing technology of 3D-printing living human tissues (bioprinting). The goals are to:

Highlight the state-of-the-art in 3D bioprinting research
Ideate on disruptive innovations that will transform bioprinting from a novel research tool to a broadly adopted systematic practice
Formulate an actionable strategy for industry engagement, clinical translation and societal impact
Present in a public forum, key messages to educate and stimulate discussion on the promises of bioprinting technology

The Roundtable will bring together a unique collection of industry experts and academic leaders to define a guiding vision to efficiently deploy bioprinting technology for the discovery and development of new therapeutics. As the novel technology of 3D bioprinting is more broadly adopted, we envision this Roundtable will become a key annual meeting to help guide the development of the technology both in Canada and globally.

We thank you for your involvement in this ground-breaking event and look forward to you all joining us in Vancouver for this unique research roundtable.

Kind Regards,
The Organizing Committee
Christian Naus, Professor, Cellular & Physiological Sciences, UBC
Vikram Yadav, Assistant Professor, Chemical & Biological Engineering, UBC
Tamer Mohamed, CEO, Aspect Biosystems
Sam Wadsworth, CSO, Aspect Biosystems
Natalie Korenic, Business Coordinator, Aspect Biosystems

I’m glad to see this event is taking place—and with public events too! (Wish I’d seen the Café Scientifique announcement earlier when I first checked for tickets  yesterday. I was hoping there’d been some cancellations today.) Finally, for the interested, you can find Aspect Biosystems here.

More from PETA (People for the Ethical Treatment of Animals) about nanomaterials and lungs

Science progress by increments. First, there was this April 27, 2016 post featuring some recent work by the organization, People for the Ethical Treatment of Animals (PETA) focused on nanomaterials and lungs. Now approximately one month later, PETA announces a new paper on the topic according to a May 26, 2016 news item on phys.org,

A scientist from the PETA International Science Consortium Ltd. is the lead author of a review on pulmonary fibrosis that results from inhaling nanomaterials, which has been published in Archives of Toxicology. The coauthors are scientists from Health Canada, West Virginia University, and the University of Fribourg in Switzerland.

A May 26, 2016 PETA news release on EurekAlert, which originated the news item, provides more detail (Note: Links have been removed),

The increasing use of nanomaterials in consumer goods such as paint, building materials, and food products has increased the likelihood of human exposure. Inhalation is one of the most prominent routes by which exposure can occur, and because inhalation of nanomaterials may be linked to lung problems such as pulmonary fibrosis, testing is conducted to assess the safety of these materials.

The review is one part of the proceedings of a 2015 workshop [mentioned in my Sept. 3, 2015 posting] organized by the PETA International Science Consortium, at which scientists discussed recommendations for designing an in vitro approach to assessing the toxicity of nanomaterials in the human lung. The workshop also produced another report that was recently published in Archives of Toxicology (Clippinger et al. 2016) and a review published in Particle and Fibre Toxicology (Polk et al. 2016) [mentioned in my April 27, 2016 posting] on exposing nanomaterials to cells grown in vitro.

The expert recommendations proposed at the workshop are currently being used to develop an in vitro system to predict the development of lung fibrosis in humans, which is being funded by the Science Consortium.

“International experts who took part in last year’s workshop have advanced the understanding and application of non-animal methods of studying nanomaterial effects in the lung,” says Dr. Monita Sharma, nanotoxicology specialist at the Consortium and lead author of the review in Archives of Toxicology. “Good science is leading the way toward more humane testing of nanomaterials, which, in turn, will lead to better protection of human health.”

Here’s a link to and a citation for the paper,

Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs) by Monita Sharma, Jake Nikota, Sabina Halappanavar, Vincent Castranova, Barbara Rothen-Rutishauser, Amy J. Clippinger. Archives of Toxicology pp 1-18 DOI: 10.1007/s00204-016-1742-7 First online: 23 May 2016

This paper is behind a paywall.