Tag Archives: Brazil

Natural nanoparticles can form clouds and encourage precipitation over the Amazon rainforest

I don’t usually stumble across stories about natural nanoparticles; almost all the stories here are about engineered nanoparticles. Nice to get a change of pace. Plus, I love rain. as I sit here composing this post, the rain is pelting against my windows.

This November 8, 2024 news item on ScienceDaily announces a natural nanoparticle story that is centered on the Amazon rainforest,

Atmospheric aerosol particles are essential for the formation of clouds and precipitation, thereby influencing the Earth’s energy budget, water cycle, and climate. However, the origin of aerosol particles in pristine air over the Amazon rainforest during the wet season is poorly understood. A new study, led by the Max Planck Institute for Chemistry in Mainz, reveals that rainfall regularly induces bursts of newly formed nanoparticles in the air above the forest canopy.

Caption: A rain front approaches the ATTO research station in the Amazon rainforest. Credit: Sebastian Brill, Max Planck Institute for Chemistry

A November 8, 2024 Max Planck Institute for Chemistry press release (also on EurekAlert), which originated the news item, provides more details,

An international research team from Germany, Brazil, Sweden, and China now showed that rainfall regularly induces bursts of nanoparticles that can grow to form cloud condensation nuclei. The scientists analyzed comprehensive long-term measurements of aerosol particles, trace gases, and meteorological data from the Amazon Tall Tower Observatory, ATTO, which is equipped with sophisticated instrumentation and measurement towers that are up to 325 m high. The observatory is located in the middle of the Amazon rainforest in northern Brazil, about 150 kilometers north-east of Manaus, and jointly operated by scientists from Germany and Brazil.

Luiz Machado, first author of the study now published in the journal Nature Geoscience, explains: “Rainfall removes aerosol particles and introduces ozone from the atmosphere into the forest canopy. Ozone can oxidize plant-emitted volatile organic compounds, especially terpenes, and the oxidation products can enhance the formation of new particles, leading to temporary bursts of nanoparticles.”

Nanoparticle concentrations are highest just above the forest canopy

The researchers discovered that nanoparticle concentrations are highest just above the forest canopy and decrease with increasing altitude. “This gradient persists throughout the wet season, indicating continuous particle formation in the canopy and an upward flux of newly formed particles that can grow by further uptake of low volatile molecules and serve as cloud condensation nuclei”, adds Christopher Pöhlker, co-author and research group leader at the Max Planck Institute for Chemistry. Among the low volatile molecules involved in the formation and growth of natural nanoparticles in the atmosphere are oxygen- and nitrogen-containing organic compounds that are formed upon oxidation of isoprene, terpenes, and other volatile organic compounds, which are naturally emitted by plants and oxidized by ozone and hydroxyl radicals in the air.

Earlier studies had detected new particle formation in the outflow of convective clouds in the upper troposphere and suggested a downward flux rather than an upward flux of newly formed nanoparticles.

“Our findings imply a paradigm shift in the scientific understanding of interactions between the rainforest, aerosols, clouds, and precipitation in the Amazon, which are important for regional and global climate”, concludes Ulrich Pöschl, co-author and director at the Max Planck Institute for Chemistry.

About ATTO:
The Amazon Tall Tower Observatory (ATTO) is an internationally collaborative research site in the central Amazon, dedicated to studying atmospheric processes and the exchange of energy, water, and gases between the biosphere and atmosphere. It is one of the world’s most critical observatories for understanding the impacts of climate change on tropical forests.

Here’s a link to and a citation for the paper,

Frequent rainfall-induced new particle formation within the canopy in the Amazon rainforest by Luiz A. T. Machado, Gabriela R. Unfer, Sebastian Brill, Stefanie Hildmann, Christopher Pöhlker, Yafang Cheng, Jonathan Williams, Harder Hartwig, Meinrat O. Andreae, Paulo Artaxo, Joachim Curtius, Marco A. Franco, Micael A. Cecchini, Achim Edtbauer, Thorsten Hoffmann, Bruna Holanda, Théodore Khadir, Radovan Krejci, Leslie A. Kremper, Yunfan Liu, Bruno B. Meller, Mira L. Pöhlker, Carlos A. Quesada, Akima Ringsdorf, Ilona Riipinen, Susan Trumbore, Stefan Wolff, Jos Lelieveld & Ulrich Pöschl. Nature Geoscience volume 17, pages 1225–1232 (2024) DOI: https://doi.org/10.1038/s41561-024-01585-0 Published online: 08 November 2024 Issue Date: December 2024

This paper is open access.

Science policy updates (INGSA in Canada and SCWIST)

I had just posted my Aug. 30, 2021 piece (4th International Conference on Science Advice to Governments (INGSA2021) August 30 – September 2, 2021) when the organization issued a news release, which was partially embargoed. By the time this is published (after 8 am ET on Wednesday, Sept. 1, 2021), the embargo will have lifted and i can announce that Rémi Quirion, Chief Scientist of Québec (Canada), has been selected to replace Sir Peter Gluckman (New Zealand) as President of INGSA.

Here’s the whole August 30, 2021 International Network for Government Science Advice (INGSA) news release on EurekAlert, Note: This looks like a direct translation from a French language news release, which may account for some unusual word choices and turns of phrase,

What? 4th International Conference on Science Advice to Governments, INGSA2021.

Where? Palais des Congrès de Montréal, Québec, Canada and online at www.ingsa2021.org

When? 30 August – 2 September, 2021.

CONTEXT: The largest ever independent gathering of interest groups, thought-leaders, science advisors to governments and global institutions, researchers, academics, communicators and diplomats is taking place in Montreal and online. Organized by Prof Rémi Quirion, Chief Scientist of Québec, speakers from over 50 countries[1] from Brazil to Burkina Faso and from Ireland to Indonesia, plus over 2000 delegates from over 130 countries, will spotlight what is really at stake in the relationship between science and policy-making, both during crises and within our daily lives. From the air we breathe, the food we eat and the cars we drive, to the medical treatments or the vaccines we take, and the education we provide to children, this relationship, and the decisions it can influence, matter immensely.  

Prof Rémi Quirion, Conference Organizer, Chief Scientist of Québec and incoming President of INGSA added: “For those of us who believe wholeheartedly in evidence and the integrity of science, the past 18 months have been challenging. Information, correct and incorrect, can spread like a virus. The importance of open science and access to data to inform our UN sustainable development goals discussions or domestically as we strengthen the role of cities and municipalities, has never been more critical. I have no doubt that this transparent and honest platform led from Montréal will act as a carrier-wave for greater engagement”.

Chief Science Advisor of Canada and Conference co-organizer, Dr Mona Nemer, stated that: “Rapid scientific advances in managing the Covid pandemic have generated enormous public interest in evidence-based decision making. This attention comes with high expectations and an obligation to achieve results. Overcoming the current health crisis and future challenges will require global coordination in science advice, and INGSA is well positioned to carry out this important work. Canada and our international peers can benefit greatly from this collaboration.”

Sir Peter Gluckman, founding Chair of INGSA stated that: “This is a timely conference as we are at a turning point not just in the pandemic, but globally in our management of longer-term challenges that affect us all. INGSA has helped build and elevate open and ongoing public and policy dialogue about the role of robust evidence in sound policy making”.

He added that: “Issues that were considered marginal seven years ago when the network was created are today rightly seen as central to our social, environmental and economic wellbeing. The pandemic highlights the strengths and weaknesses of evidence-based policy-making at all levels of governance. Operating on all continents, INGSA demonstrates the value of a well-networked community of emerging and experienced practitioners and academics, from countries at all levels of development. Learning from each other, we can help bring scientific evidence more centrally into policy-making. INGSA has achieved much since its formation in 2014, but the energy shown in this meeting demonstrates our potential to do so much more”.

Held previously in Auckland 2014, Brussels 2016, Tokyo 2018 and delayed for one year due to Covid, the advantage of the new hybrid and virtual format is that organizers have been able to involve more speakers, broaden the thematic scope and offer the conference as free to view online, reaching thousands more people. Examining the complex interactions between scientists, public policy and diplomatic relations at local, national, regional and international levels, especially in times of crisis, the overarching INGSA2021 theme is: “Build back wiser: knowledge, policy & publics in dialogue”.

The first three days will scrutinize everything from concrete case-studies outlining successes and failures in our advisory systems to how digital technologies and AI are reshaping the profession itself. The final day targets how expertize and action in the cultural context of the French-speaking world is encouraging partnerships and contributing to economic and social development. A highlight of the conference is the 2 September announcement of a new ‘Francophonie Science Advisory Network’.       

Prof. Salim Abdool Karim, a member of the World Health Organization’s Science Council, and the face of South Africa’s Covid-19 science, speaking in the opening plenary outlined that: “As a past anti-apartheid activist now providing scientific advice to policy-makers, I have learnt that science and politics share common features. Both operate at the boundaries of knowledge and uncertainty, but approach problems differently. We scientists constantly question and challenge our assumptions, constantly searching for empiric evidence to determine the best options. In contrast, politicians are most often guided by the needs or demands of voters and constituencies, and by ideology”.

He added: “What is changing is that grass-roots citizens worldwide are no longer ill-informed and passive bystanders. And they are rightfully demanding greater transparency and accountability. This has brought the complex contradictions between evidence and ideology into the public eye. Covid-19 is not just a disease, its social fabric exemplifies humanity’s interdependence in slowing global spread and preventing new viral mutations through global vaccine equity. This starkly highlights the fault-lines between the rich and poor countries, especially the maldistribution of life-saving public health goods like vaccines. I will explore some of the key lessons from Covid-19 to guide a better response to the next pandemic”.

Speaking on a panel analysing different advisory models, Prof. Mark Ferguson, Chair of the European Innovation Council’s Advisory Board and Chief Science Advisor to the Government of Ireland, sounded a note of optimism and caution in stating that: “Around the world, many scientists have become public celebrities as citizens engage with science like never before. Every country has a new, much followed advisory body. With that comes tremendous opportunities to advance the status of science and the funding of scientific research. On the flipside, my view is that we must also be mindful of the threat of science and scientists being viewed as a political force”.

Strength in numbers

What makes the 4th edition of this biennial event stand out is the perhaps never-before assembled range of speakers from all continents working at the boundary between science, society and policy willing to make their voices heard. In a truly ‘Olympics’ approach to getting all stakeholders on-board, organisers succeeded in involving, amongst others, the UN Office for Disaster Risk Reduction, the United Nations Development Programme, UNESCO and the OECD. The in-house science services of the European Commission and Parliament, plus many country-specific science advisors also feature prominently.

As organisers foster informed debate, we get a rare glimpse inside the science advisory worlds of the Comprehensive Nuclear Test Ban Treaty Organisation, the World Economic Forum and the Global Young Academy to name a few. From Canadian doctors, educators and entrepreneurs and charitable foundations like the Welcome Trust, to Science Europe and media organisations, the programme is rich in its diversity. The International Organisation of the Francophonie and a keynote address by H.E. Laurent Fabius, President of the Constitutional Council of the French Republic are just examples of two major draws on the final day dedicated to spotlighting advisory groups working through French. 

INGSA’s Elections: New Canadian President and Three Vice Presidents from Chile, Ethiopia, UK

The International Network for Government Science Advice has recently undertaken a series of internal reforms intended to better equip it to respond to the growing demands for support from its international partners, while realising the project proposals and ideas of its members.

Part of these reforms included the election in June, 2021 of a new President replacing Sir Peter Gluckman (2014 – 2021) and the creation of three new Vice President roles.

These results will be announced at 13h15 on Wednesday, 1st September during a special conference plenary and awards ceremony. While noting the election results below, media are asked to respect this embargo.

Professor Rémi Quirion, Chief Scientist of Québec (Canada), replaces Sir Peter Gluckman (New Zealand) as President of INGSA.
 

Professor Claire Craig (United Kingdom), CBE, Provost of Queen’s College Oxford and a member of the UK government’s AI Council, has been elected by members as the inaugural Vice President for Evidence.
 

Professor Binyam Sisay Mendisu (Egypt), PhD, Lecture at the University of Addis Ababa and Programme Advisor, UNESCO Institute for Building Capacity in Africa, has been elected by members as the inaugural Vice President for Capacity Building.
 

Professor Soledad Quiroz Valenzuela (Chile), Science Advisor on Climate Change to the Ministry of Science, Technology, Knowledge and Innovation of the government of Chile, has been elected by members as the Vice President for Policy.

Satellite Events: From 7 – 9 September, as part of INGSA2021, the conference is partnering with local,  national and international organisations to ignite further conversations about the science/policy/society interface. Six satellite events are planned to cover everything from climate science advice and energy policy, open science and publishing during a crisis, to the politicisation of science and pre-school scientific education. International delegates are equally encouraged to join in online. 

About INGSA: Founded in 2014 with regional chapters in Africa, Asia and Latin America and the Caribbean, INGSA has quicky established an important reputation as aa collaborative platform for policy exchange, capacity building and research across diverse global science advisory organisations and national systems. Currently, over 5000 individuals and institutions are listed as members. Science communicators and members of the media are warmly welcomed to join.

As the body of work detailed on its website shows (www.ingsa.org) through workshops, conferences and a growing catalogue of tools and guidance, the network aims to enhance the global science-policy interface to improve the potential for evidence-informed policy formation at sub-national, national and transnational levels. INGSA operates as an affiliated body of the International Science Council which acts as trustee of INGSA funds and hosts its governance committee. INGSA’s secretariat is based in Koi Tū: The Centre for Informed Futures at the University of Auckland in New Zealand.

Conference Programme: 4th International Conference on Science Advice to Government (ingsa2021.org)

Newly released compendium of Speaker Viewpoints: Download Essays From The Cutting Edge Of Science Advice – Viewpoints

[1] Argentina, Australia, Austria, Barbados, Belgium, Benin, Brazil, Burkina Faso, Cameroon, Canada, Chad, Colombia, Costa Rica, Côte D’Ivoire, Denmark, Estonia, Finland, France, Germany, Hong Kong, Indonesia, Ireland, Japan, Lebanon, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, New Zealand, Pakistan, Papua New Guinea, Rwanda, Senegal, Singapore, Slovakia, South Africa, Spain, Sri Lanka, Sweden, Switzerland, Thailand, UK, USA. 

Society for Canadian Women in Science and Technology (SCWIST)

As noted earlier this year in my January 28, 2021 posting, it’s SCWIST’s 40th anniversary and the organization is celebrating with a number of initiatives, here are some of the latest including as talk on science policy (from the August 2021 newsletter received via email),

SCWIST “STEM Forward Project”
Receives Federal Funding

SCWIST’s “STEM Forward for Economic Prosperity” project proposal was among 237 projects across the country to receive funding from the $100 million Feminist Response Recovery Fund of the Government of Canada through the Women and Gender Equality Canada (WAGE) federal department.

Read more. 

iWIST and SCWIST Ink Affiliate MOU [memorandum of understanding]

Years in planning, the Island Women in Science and Technology (iWIST) of Victoria, British Columbia and SCWIST finally signed an Affiliate MOU (memorandum of understanding) on Aug 11, 2021.

The MOU strengthens our commitment to collaborate on advocacy (e.g. grants, policy and program changes at the Provincial and Federal level), events (networking, workshops, conferences), cross promotion ( event/ program promotion via digital media), and membership growth (discounts for iWIST members to join SCWIST and vice versa).

Dr. Khristine Carino, SCWIST President, travelled to Victoria to sign the MOU in person. She was invited as an honoured guest to the iWIST annual summer picnic by Claire Skillen, iWIST President. Khristine’s travel expenses were paid from her own personal funds.

Discovery Foundation x SBN x SCWIST Business Mentorship Program: Enhancing Diversity in today’s Biotechnology Landscape

The Discovery Foundation, Student Biotechnology Network, and Society for Canadian Women in Science and Technology are proud to bring you the first-ever “Business Mentorship Program: Enhancing Diversity in today’s Biotechnology Landscape”. 

The Business Mentorship Program aims to support historically underrepresented communities (BIPOC, Women, LGBTQIAS+ and more) in navigating the growth of the biotechnology industry. The program aims to foster relationships between individuals and professionals through networking and mentorship, providing education and training through workshops and seminars, and providing 1:1 consultation with industry leaders. Participants will be paired with mentors throughout the week and have the opportunity to deliver a pitch for the chance to win prizes at the annual Building Biotechnology Expo. 

This is a one week intensive program running from September 27th – October 1st, 2021 and is limited to 10 participants. Please apply early. 

Events

September 10

Art of Science and Policy-Making Go Together

Science and policy-making go together. Acuitas’ [emphasis mine] Molly Sung shares her journey and how more scientists need to engage in this important area.

September 23

Au-delà de l’apparence :

des femmes de courage et de résilience en STIM

Dans le cadre de la semaine de l’égalité des sexes au Canada, ce forum de la division québécoise de la Société pour les femmes canadiennes en science et technologie (la SCWIST) mettra en vedette quatre panélistes inspirantes avec des parcours variés qui étudient ou travaillent en science, technologie, ingénierie et mathématiques (STIM) au Québec. Ces femmes immigrantes ont laissé leurs proches et leurs pays d’origine pour venir au Québec et contribuer activement à la recherche scientifique québécoise. 

….

The ‘Art and Science Policy-Making Go Together’ talk seems to be aimed at persuasion and is not likely to offer any insider information as to how the BC life sciences effort is progressing. For a somewhat less rosy view of science and policy efforts, you can check out my August 23, 2021 posting, Who’s running the life science companies’ public relations campaign in British Columbia (Vancouver, Canada)?; scroll down to ‘The BC biotech gorillas’ subhead for more about Acuitas and some of the other life sciences companies in British Columbia (BC).

For some insight into how competitive the scene is here in BC, you can see my August 20, 2021 posting (Getting erased from the mRNA/COVID-19 story) about Ian MacLachlan.

You can check out more at the SCWIST website and I’m not sure when the August issue will be placed there but they do have a Newsletter Archive.

Mystery of North American insect bioluminescent systems unraveled by Brazilian scientists

I’ve always been fond of ‘l’ words and so it is that I’m compelled to post a story about a “luciferin-luciferase system” or, in this case, a story about insect bioluminescence.

Caption: Researchers isolated molecules present in the larvae of the fungus gnat Orfelia fultoni Credit: Vadim Viviani, UFSCar

A September 9, 2020 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) press release (also on EurekAlert but published Sept. 11, 2020) announces research into ‘blue’ bioluminescence,

Molecules belonging to an almost unknown bioluminescent system found in larvae of the fungus gnat Orfelia fultoni (subfamily Keroplatinae) have been isolated for the first time by researchers at the Federal University of São Carlos (UFSCar) in the state of São Paulo, Brazil. The small fly is one of the few terrestrial organisms that produce blue light. It inhabits riverbanks in the Appalachian Mountains in the eastern United States. A key part of its bioluminescent system is a molecule also present in two recently discovered Brazilian flies.

The study, supported by Paulo Research Foundation – FAPESP, is published in Scientific Reports. Five authors are affiliated with UFSCar and two with universities in the United States.

The bioluminescent systems of glow-worms, fireflies and other insects are normally made up of luciferin (a low molecular weight molecule) and luciferase, an enzyme that catalyzes the oxidation of luciferin by oxygen, producing light. While some bioluminescent systems are well known and even used in biotechnological applications, others are poorly understood, including blue light-emitting systems, such as that of O. fultoni.

“In the published paper, we describe the properties of the insect’s luciferase and luciferin and their anatomical location in its larvae. We also specify several possible proteins that are possible candidates for the luciferase. We don’t yet know what type of protein it is, but it’s likely to be a hexamerin. In insects, hexamerins are storage proteins that provide amino acids, besides having other functions, such as binding low molecular weight compounds, like luciferin,” said Vadim Viviani, a professor in UFSCar’s Sustainability Science and Technology Center (CCTS) in Sorocaba, São Paulo, and principal investigator for the study.

The study was part of the FAPESP-funded project “Arthropod bioluminescence“. The partnership with United States-based researchers dates from a previous project, supported by FAPESP and the United States National Science Foundation (NSF), in partnership with Vanderbilt University (VU), located in Nashville, Tennessee.

In addition to luciferin and luciferase, researchers began characterizing a complex found in insects of the family Keroplatidae, which, in addition to O. fultoni, also includes a Brazilian species in the genus Neoditomyia that produces only luciferin and hence does not emit light.

Because they do not use it to emit light, the luciferin in O. fultoni and the Brazilian Neoditomyia has been named keroplatin. In larvae of this subfamily, keroplatin is associated with “black bodies” – large cells containing dark granules, proteins and probably mitochondria (energy-producing organelles). Researchers are still investigating the biological significance of this association between keroplatin and mitochondria.

“It’s a mystery,” Viviani said. “This luciferin may play a role in the mitochondrial energy metabolism. At night, probably in the presence of a natural chemical reducer, the luciferin is released by these black bodies and reacts with the surrounding luciferase to produce blue light. These are possibilities we plan to study.”

Brazilian cousins

An important factor in the elucidation of the United States insect’s bioluminescent system was the discovery of a larva that lives in Intervales State Park in São Paulo in 2018. It does not emit light but produces luciferin, similar to O. fultoni (read more at: agencia.fapesp.br/29066).

In their latest study, the group injected purified luciferase from the United States species into larvae of the Brazilian species, which then produced blue light. The nonluminescent Brazilian species is more abundant in nature than the United States species, so a larger amount of the material could be obtained for study purposes, especially to characterize the luciferin (keroplatin) present in both species.

In 2019, the group discovered and described Neoceroplatus betaryensis, a new species of fungus gnat, in collaboration with Cassius Stevani, a professor at the University of São Paulo’s Institute of Chemistry (IQ-USP). It was the first blue light-emitting insect found in South America and was detected in a privately held forest reserve near the Upper Ribeira State Tourist Park (PETAR) in the southern portion of the state of São Paulo. A close relative of O. fultoni, N. betaryensis inhabits fallen tree trunks in humid places (read more at: agencia.fapesp.br/31797).

“We show that the bioluminescent system of this Brazilian species is identical to that of O. fultoni. However, the insect is very rare, and so it’s hard to obtain sufficient material for research purposes,” Viviani said.

The researchers are now cloning the insect’s luciferase and characterizing it in molecular terms. They are also analyzing the chemical structure of its luciferin and the morphology of its lanterns.

“Once all this has been determined, we’ll be able to synthesize the luciferin and luciferase in the lab and use these systems in a range of biotech applications, such as studying cells. This will help us understand more about human diseases, among other things,” Viviani said.

Here’s a link to and a citation for the paper,

A new brilliantly blue-emitting luciferin-luciferase system from Orfelia fultoni and Keroplatinae (Diptera) by Vadim R. Viviani, Jaqueline R. Silva, Danilo T. Amaral, Vanessa R. Bevilaqua, Fabio C. Abdalla, Bruce R. Branchini & Carl H. Johnson. Scientific Reports volume 10, Article number: 9608 (2020) DOI: https://doi.org/10.1038/s41598-020-66286-1 Published 15 June 2020

This paper is open access.

Spotting the difference between dengue and Zika infections with gold nanosensors

This July 29, 2020 news item on Nanowerk features research from Brazil,

A new class of nanosensor developed in Brazil could more accurately identify dengue and Zika infections, a task that is complicated by their genetic similarities and which can result in misdiagnosis.

The technique uses gold nanoparticles and can “observe” viruses at the atomic level, according to a study published in Scientific Reports (“Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections”).

Belonging to the Flavivirus genus in the Flaviviridae family, Zika and dengue viruses share more than 50 per cent similarity in their amino acid sequence. Both viruses are spread by mosquitos and can have long-term side effects. The Flaviviridae virus family was named after the yellow fever virus and comes from the Latin word for golden, or yellow, in colour.

“Diagnosing [dengue virus] infections is a high priority in countries affected by annual epidemics of dengue fever. The correct diagnostic is essential for patient managing and prognostic as there are no specific antiviral drugs to treat the infection,” the authors say.

More than 1.8 million people are suspected to have been infected with dengue so far this year in the Americas, with 4000 severe cases and almost 700 deaths, the Pan American Health Organization says. The annual global average is estimated to be between 100 million and 400 million dengue infections, according to the World Health Organization.

Flávio Fonseca, study co-author and researcher at the Federal University of Minas Gerais, tells SciDev.Net it is almost impossible to differentiate between dengue and Zika viruses.

“A serologic test that detects antibodies against dengue also captures Zika-generated antibodies. We call it cross-reactivity,” he says.

Meghie Rodrigues’ July 29, 2020 article for SciDev.net, which originated the news item, delves further into the work,

Co-author and virologist, Maurício Nogueira, tells SciDev.Net that avoiding cross-reactivity is crucial because “dengue is a disease that kills — and can do so quickly if the right diagnosis is not made. As for Zika, it offers risks for foetuses to develop microcephaly, and we can’t let pregnant women spend seven or eight months wondering whether they have the virus or not.”

There is also no specific antiviral treatment for Zika and the search for a vaccine is ongoing.

Virus differentiation is important to accurately measure the real impact of both diseases on public health. The most widely used blood test, the enzyme-linked immunosorbent assay (ELISA), is limited in its ability to tell the difference between the viruses, the authors say.

As dengue has four variations, known as serotypes, the team created four different nanoparticles and covered each of them with a different dengue protein. They applied ELISA serum and a blood sample. The researchers found that sample antibodies bound with the viruses’ proteins, changing the pattern of electrons on the gold nanoparticle surface.

Should you check out Rodrigues’ entire article, you might want to take some time to explore SciDev.net to find science news from countries that don’t often get the coverage they should.

Here’s a link to and a citation for the researchers’ paper,

Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections by Alice F. Versiani, Estefânia M. N. Martins, Lidia M. Andrade, Laura Cox, Glauco C. Pereira, Edel F. Barbosa-Stancioli, Mauricio L. Nogueira, Luiz O. Ladeira & Flávio G. da Fonseca. Scientific Reports volume 10, Article number: 11302 (2020) DOI: https://doi.org/10.1038/s41598-020-68357-9 Published: 09 July 2020

This paper is open access.

Taxonomies (classification schemes) rouse passions

There seems to have been some lively debate among biologists about matters most of us treat as invisible: naming, establishing, and classifying categories. These activities can become quite visible when learning a new language, e.g., French which divides nouns into two genders or German which classifies nouns with any of three genders.

A July 26, 2020 essay by Stephen Garnett (Professor of Conservation and Sustainable Livelihoods, Charles Darwin University, Australia), Les Christidis (Professor, Southern Cross University, Australia), Richard L. Pyle (Associate lecturer, University of Hawaii, US), and Scott Thomson (Research associate, Universidade de São Paulo, Brazil) for The Conversation (also on phys.org but published July 27, 2020) describes a very heated debate over taxonomy,

Taxonomy, or the naming of species, is the foundation of modern biology. It might sound like a fairly straightforward exercise, but in fact it’s complicated and often controversial.

Why? Because there’s no one agreed list of all the world’s species. Competing lists exist for organisms such as mammals and birds, while other less well-known groups have none. And there are more than 30 definitions of what constitutes a species [emphasis mine]. This can make life difficult for biodiversity researchers and those working in areas such as conservation, biosecurity and regulation of the wildlife trade.

In the past few years, a public debate erupted among global taxonomists, including those who authored and contributed to this article, about whether the rules of taxonomy should be changed. Strongly worded ripostes were exchanged. A comparison to Stalin [emphasis mine] was floated.

Here’s how it started,

In May 2017 two of the authors, Stephen Garnett and Les Christidis, published an article in Nature. They argued taxonomy needed rules around what should be called a species, because currently there are none. They wrote:

” … for a discipline aiming to impose order on the natural world, taxonomy (the classification of complex organisms) is remarkably anarchic […] There is reasonable agreement among taxonomists that a species should represent a distinct evolutionary lineage. But there is none about how a lineage should be defined.

‘Species’ are often created or dismissed arbitrarily, according to the individual taxonomist’s adherence to one of at least 30 definitions. Crucially, there is no global oversight of taxonomic decisions — researchers can ‘split or lump’ species with no consideration of the consequences.”

Garnett and Christidis proposed that any changes to the taxonomy of complex organisms be overseen by the highest body in the global governance of biology, the International Union of Biological Sciences (IUBS), which would “restrict […] freedom of taxonomic action.”

… critics rejected the description of taxonomy as “anarchic”. In fact, they argued there are detailed rules around the naming of species administered by groups such as the International Commission on Zoological Nomenclature and the International Code of Nomenclature for algae, fungi, and plants. For 125 years, the codes have been almost universally adopted by scientists.

So in March 2018, 183 researchers – led by Scott Thomson and Richard Pyle – wrote an animated response to the Nature article, published in PLoS Biology [PLoS is Public Library of Science; it is an open access journal].

They wrote that Garnett and Christidis’ IUBS proposal was “flawed in terms of scientific integrity […] but is also untenable in practice”. They argued:

“Through taxonomic research, our understanding of biodiversity and classifications of living organisms will continue to progress. Any system that restricts such progress runs counter to basic scientific principles, which rely on peer review and subsequent acceptance or rejection by the community, rather than third-party regulation.”

In a separate paper, another group of taxonomists accused Garnett and Christidis of trying to suppress freedom of scientific thought, likening them to Stalin’s science advisor Trofim Lysenko.

The various parties did come together,

We hope by 2030, a scientific debate that began with claims of anarchy might lead to a clear governance system – and finally, the world’s first endorsed global list of species.

As for how they got to a “clear governance system”, there’s the rest of the July 26, 2020 essay on The Conversation or there’s the copy on phys.org (published July 27, 2020).

Optical fibers made from marine algae

Apparently after you’ve finished imaging with your marine algae-based optical fibers, you can eat them. A July 24, 2020 news item on Nanowerk announces the new research,

An optical fiber made of agar has been produced at the University of Campinas (UNICAMP) in the state of São Paulo, Brazil. This device is edible, biocompatible and biodegradable. It can be used in vivo for body structure imaging, localized light delivery in phototherapy or optogenetics (e.g., stimulating neurons with light to study neural circuits in a living brain), and localized drug delivery.

Another possible application is the detection of microorganisms in specific organs, in which case the probe would be completely absorbed by the body after performing its function.

Caption: Edible, biocompatible and biodegradable, these fibers have potential for various medical applications. Credit: Eric Fujiwara

A July 24, 2020 Fundação de Amparo à Pesquisa dFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) do Estado de São Paulo press release on EurekAlert, which originated the news item, provides a few more details about the researches and the work,

The research project, which was supported by São Paulo Research Foundation – FAPESP, was led by Eric Fujiwara, a professor in UNICAMP’s School of Mechanical Engineering, and Cristiano Cordeiro, a professor in UNICAMP’s Gleb Wataghin Institute of Physics, in collaboration with Hiromasa Oku, a professor at Gunma University in Japan.

An article on the study is published) in Scientific Reports, an online journal owned by Springer Nature.

Agar, also called agar-agar, is a natural gelatin obtained from marine algae. Its composition consists of a mixture of two polysaccharides, agarose and agaropectin. “Our optical fiber is an agar cylinder with an external diameter of 2.5 millimeters [mm] and a regular inner arrangement of six 0.5 mm cylindrical airholes around a solid core. Light is confined owing to the difference between the refraction indices of the agar core and the airholes,” Fujiwara told.

“To produce the fiber, we poured food-grade agar into a mold with six internal rods placed lengthwise around the main axis,” he continued. “The gel distributes itself to fill the available space. After cooling, the rods are removed to form airholes, and the solidified waveguide is released from the mold. The refraction index and geometry of the fiber can be adapted by varying the composition of the agar solution and mold design, respectively.”

The researchers tested the fiber in different media, from air and water to ethanol and acetone, concluding that it is context-sensitive. “The fact that the gel undergoes structural changes in response to variations in temperature, humidity and pH makes the fiber suitable for optical sensing,” Fujiwara said.

Another promising application is its simultaneous use as an optical sensor and a growth medium for microorganisms. “In this case, the waveguide can be designed as a disposable sample unit containing the necessary nutrients. The immobilized cells in the device would be optically sensed, and the signal would be analyzed using a camera or spectrometer,” he said.

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About São Paulo Research Foundation (FAPESP)

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at http://www.fapesp.br/en and visit FAPESP news agency at http://www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe.

As per my usual practice, here’s a link to and a citation for the paper,

Agarose-based structured optical fibre by Eric Fujiwara, Thiago D. Cabral, Miko Sato, Hiromasa Oku & Cristiano M. B. Cordeiro. Scientific Reports volume 10, Article number: 7035 (2020) DOI: https://doi.org/10.1038/s41598-020-64103-3 Published: 27 April 2020

This paper is open access.

Should you have a problem accessing the English language version of the FAPESP website, the Portuguese language version of the site seems more accessible (assuming you have the language skills).

Walking again with exoskeletons and brain-controlled, non-invasive muscle stimulation enabling people to walk

I have two news bits about paraplegics and the possibility of walking. The first is from Alberta, Canada and the second is from Brazil.

Alberta

The fellow in the video is wearing a robotic exoskeleton. As you can see, it’s not perfect but it represents an extraordinary breakthrough (from an April 16, 2019 article by Sarah Lawrynuik for the Canadian Broadcasting Corporation [CBC] Radio),

On his fifteenth birthday in December 2015, Calgary’s Alex McEwan was injured in a tobogganing accident with friends and lost the ability to walk. It’s the kind of change that could destroy a person, but Alex has thrived and is learning new skills. Watch him walk onstage, with some help from a powered exoskeleton, to receive his diploma. 1:21

Sometimes events conspire to move us in a completely unexpected ways. After his accident, Alex McEwan participated in a very special study (from an August 3, 2019 article by Colin Zak for Alberta Health Services),

Researchers at Foothills Medical Centre (FMC) are the first in Canada to examine the benefits of using an exoskeleton robotic device to rehabilitate patients with spinal cord injuries (SCI) in the days and weeks following their injury.

The device, known as the Ekso Bionic Exoskeleton, consists of a metal frame that supports and stabilizes a patient’s torso, core, legs and feet. It is moved robotically by a therapist, enabling patients with a spinal cord injury to get up and walk around. Although it is controlled by remote control, the device offers varying levels of physical control by the patient, depending on the nature and extent of their injury.

Dr. Ho [ Dr. Chester Ho, Head of Physical Medicine and Rehabilitation at FMC ] says exoskeletons may potentially promote recovery and reduce complications in SCI patients by reducing loss of bone and muscle mass caused by spending so much time lying down, and also improve breathing and bowel function.

The year-long study, which begins this summer, will include between five and 10 patients selected from across Calgary [Alberta]. It aims to examine whether treatment is safe and feasible in the days and weeks after an SCI. This study will be followed by larger studies involving more patients.

Participants in the study will receive 60-minute therapy sessions with the exoskeleton device two to three times a week, for a total of 25 training hours over an eight- to 10-week period. Safety and feasibility outcomes will be monitored and tracked by the research team throughout all sessions.

Before the advent of exoskeletons, rehabilitation for patients with an SCI required them to be hoisted with a physical therapist moving their legs.

“Every step is different with this device, so patients learn from their mistakes in real time. Patients really like to use the device; it gives them hope.”

Alex, [emphasis mine] 15, sustained a spinal cord injury while tobogganing last December.

He says rehabilitation sessions with the exoskeleton have made a difference in how he feels and gives him hope for the future.

Over 2 1/2 years later, the CBC has made a radio documentary about this study and the people who took part. Lawrynuik’s April 16, 2019 article describes some highlights from the radio documentary,

Imagine waking up in a hospital bed surrounded by the beeps and whirring sounds of the machines keeping you alive. The doctor tells you that you will likely never walk again.

But then, just as you begin to process that news, a physiotherapist shows up at your bedside and says, “Hold up. I might have a special opportunity for you.”

That’s the journey taken by a number of Albertans who landed in Calgary’s Foothills Medical Centre after accidents or trauma to their spine in the last three years. Three of those people are Alex McEwan, a university student in Lethbridge; Jean Ogilvie, a 77-year-old woman living in Calgary; and Josh Pelland, a former climber turned motivational speaker in Three Hills, Alta.

All three are united by a technology called an exoskeleton, created by a company called Ekso Bionics, that allowed them to walk despite no longer being able to use their legs. 

“The first time was a bit scary actually,” Ogilvie said. “It’s like a great big skeleton that sort of clasps you in its body. [It’s] black and all sorts of straps and sensors tell you how I’m doing.”

Pelland agrees about how daunting the experience is to start.

“They just said, ‘OK, the machine is going to assist you and lift you up.’ And I was a bit like, ‘OK, this is the strangest thing ever.'”

Once the frame of the exoskeleton is strapped along the outside of the patient’s legs and up their back, starting from the seated position, it does lift them completely without the help of their own muscles.

From there they shift their upper-body weight within the machine to hit certain targets — once your body weight is shifted forward and laterally enough, a beep sounds and the exoskeleton pulls each leg forward, one at a time. 

As patients learn to use the machine, they walk with the assistance of a walker. Then, as they progress, they upgrade to forearm crutches. The entire time, they’re accompanied by the man behind the machine, Kyle McIntosh.

McIntosh is a physiotherapist and he worked with the exoskeleton both to help patients and to conduct research into the machine’s impact on rehabilitation.

After being discharged and living once again without the exoskeleton, and therefore without the ability to walk — McEwan got an idea: maybe he’d be allowed to use the robot, just one last time.

“High school wasn’t high school for me. I only really got one semester of grade 10 before I broke my spine. So that first semester was great. I enjoyed it. I played sports. I was a good student. But then it was no longer about high school anymore. It was more about adjusting to my new life.”

McIntosh and McEwan hatched the plan together and kept it a closely guarded secret. Then, on the day McEwan was set to graduate from Grade 12, he asked to be placed last on the list of students to cross the stage.

“I remember taking a first few steps and not hearing very much. Hearing people cheer because I was the kid in the wheelchair at the high school, so it makes sense. But the second they saw the canes and my first few steps, just one kid erupted: ‘Yeah!’ And then everyone went crazy.”

“I think walking across the stage — just like I got to walk into my high school on the first day of Grade 10 — was a really good closing story. The chapter of me learning to live in a wheelchair was done. And it was now my turn to go live my life. So that’s why I think it was such an important day because it gave me a lot of closure. I got to walk into the high school, I got to walk out.”

If you have the time, you might want to read Lawrynuik’s April 16, 2019 article in its entirety. It turns out that the study did much more than give a people a chance to walk again, even if just for a short time.

Anyone interested in the robotic, wearable exoskeleton used in the study can go here to EksoHealth, the company that produces the EksoGT, a bionic exoskeleton. (Lawrynuik’s article has another name for the product, i.e., Ekso Bionic Exoskeleton but all I could find was the EksoGT.)

Brazil and Walk Again

The most recent post featuring the Walk Again project is my May 20, 2014 edition which was part of a larger series on ‘Brain research, ethics, and nanotechnology’. The May 20, 2014 posting covered Walk Again’s debut at the 2014 World Cup (soccer/football) in Brazil. Unfortunately,, the lead researcher Miguel Nicolelis oversold the technology. I think people were expecting someone with paraplegia to come bounding out onto the field and give a flashy opening kick for the tournament what they saw was something a great deal more restrained.

The person was wheeled out onto the field, stood up, shuffled a bit, and nudged the ball with his foot. It represented a huge breakthrough but it wasn’t flashy.

The latest from Walk Again is in a May 14, 2019 Associação Alberto Santos Dumont para Apoio à Pesquisa press release on EurekAlert,

In another major clinical breakthrough of the Walk Again Project, a non-profit international consortium aimed at developing new neuro-rehabilitation protocols, technologies and therapies for spinal cord injury, two patients with paraplegia regained the ability to walk with minimal assistance, through the employment of a fully non-invasive brain-machine interface that does not require the use of any invasive spinal cord surgical procedure. The results of this study appeared on the May 1 [2019] issue of the journal Scientific Reports.

The two patients with paraplegia (AIS C) used their own brain activity to control the non-invasive delivery of electrical pulses to a total of 16 muscles (eight in each leg), allowing them to produce a more physiological walk than previously reported, requiring only a conventional walker and a body weight support system as assistive devices. Overall, the two patients were able to produce more than 4,500 steps using this new technology, which combines a non-invasive brain-machine interface, based on a 16-channel EEG, to control a multi-channel functional electrical stimulation system (FES), tailored to produce a much smoother gait pattern than the state of the art of this technique.

“What surprised us was that, in addition to allowing these patients to walk with little help, one of them displayed a clear motor improvement by practicing with this new approach. Patients required approximatively [sic] 25 sessions to master the training before they were able to walk using this apparatus,” said Solaiman Shokur one of the authors of the study.

The two patients that used this new rehabilitation approach had previously participated in the long-term neurorehabilitation study carried out using the Walk Again Project Neurorehabilitation (WANR) protocol. As reported in a recent publication from the same team (Shokur et al., PLoS One, Nov. 2018), all seven patients who participated in that protocol for a period of 28 months improved their clinical status, from complete paraplegia (AIS A or B, meaning no motor functions below the level of the injury, according to the ASIA classification) to partial paraplegia (AIS C, meaning partial recovery of sensory and motor function below the injury level). This significant neurological recovery included major clinical improvements in sensory discrimination (tactile, nociception, vibration, and pressure), voluntary motor control of abdomen and leg muscles, and important gains in autonomic control, such as bladder, bowel, and sexual functions.

“The last two studies published by the Walk Again Project clearly indicate that partial neurological and functional recovery can be induced in chronic spinal cord injury patients by combining multiple non-invasive technologies that are based around the concept of using a brain-machine interface to control different types of actuators, like virtual avatars, robotic walkers, or muscle stimulating devices, to allow the total involvement of patients in their own rehabilitation routine,” said Miguel Nicolelis, scientific director of the Walk Again Project and one of the authors of the study.

In a recent report by another group, one AIS C and two AIS D patients were able to walk thanks to the employment of an invasive method for spinal cord electrical stimulation, which required a spinal surgical procedure. In contrast, in the present study two AIS C patients – which originally were AIS A (see Supplemental Material below)- and a third AIS B subject, who recently achieved similar results, were able to regain a significant degree of autonomous walking without the need for such invasive treatments. Instead, these patients only received electrical stimulation patterns delivered to the skin surface of their legs, so that a total of eight muscles in each limb could be electrically stimulated in a physiologically accurate sequence. This was done in order to produce a smoother and more natural pattern of locomotion.

“Crucial for this implementation was the development of a closed-loop controller that allowed real-time correction of the patients’ walking pattern, taking into account muscle fatigue and external perturbations, in order to produce a predefined gait trajectory. Another major component of our approach was the use of a wearable haptic display to deliver tactile feedback to the patients´ forearms in order to provide them with a continuous source of proprioceptive feedback related to their walking,” said Solaiman Shokur.

To control the pattern of electrical muscle stimulation in each leg, these patients utilized an EEG-based brain-machine interface. In this setup, patients learned to alternate the generation of “stepping motor imagery” activity in their right and left motor cortices, in order to create alternated movements of their left and right legs.

According to the authors, the patients exhibited not only “less dependency on walking assistance, but also partial neurological recovery, with substantial rates of motor improvement in one of them.” The improvement in motor control in this last AIS C patient was 9 points in the lower extremity motor score (LEMS), which was comparable with that observed using invasive spinal cord stimulation.

Based on the results obtained over the past 5 years, the WAP now intends to combine all its neurorehabilitation tools into a single integrated, non-invasive platform to treat spinal cord injury patients. This platform will allow patients to begin training soon after the injury occurs. It will also allow the employment of a multi-dimensional integrated brain-machine interface capable of simultaneously controlling virtual and robotic actuators (like a lowerlimb exoskeleton), a multi-channel non-invasive electrical muscle stimulation system (like the FES used in the present study), and a novel non-invasive spinal cord stimulation approach. In this final configuration, this WAP platform will incorporate all these technologies together in order to maximize neurological and functional recovery in the shortest possible time, without the need of any invasive procedure.

According to Dr. Nicolelis, “there is no silver bullet to treat spinal cord injuries. More and more, it looks like we need to implement multiple techniques simultaneously to achieve the best neurorehabilitation results. In this context, it is also imperative to consider the occurrence of cortical plasticity as a major component in the planning of our rehabilitation approach.”

Here’s a link to and a citation for the paper,

Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia by Aurelie Selfslagh, Solaiman Shokur, Debora S. F. Campos, Ana R. C. Donati, Sabrina Almeida, Seidi Y. Yamauti, Daniel B. Coelho, Mohamed Bouri & Miguel A. L. Nicolelis. Scientific Reports volume 9, Article number: 6782 (2019) DOI: https://doi.org/10.1038/s41598-019-43041-9 Published 01 May 2019

This paper is open access.

There’s also a video for Walk Again,

Proposed nanodevice made possible by particle that is its own antiparticle (Majorana particle)

I’m not sure how much the mystery of Ettore Majorana’s disappearance in 1938 has to do with the latest research from Brazil on Majorana particles but it’s definitely fascinating,. From an April 6, 2018 news item on ScienceDaily,

In March 1938, the young Italian physicist Ettore Majorana disappeared mysteriously, leaving his country’s scientific community shaken. The episode remains unexplained, despite Leonardo Scascia’s attempt to unravel the enigma in his book The Disappearance of Majorana (1975).

Majorana, whom Enrico Fermi called a genius of Isaac Newton’s stature, vanished a year after making his main contribution to science. In 1937, when he was only 30, Majorana hypothesized a particle that is its own anti-particle and suggested that it might be the neutrino, whose existence had recently been predicted by Fermi and Wolfgang Pauli.

Eight decades later, Majorana fermions, or simply majoranas, are among the objects most studied by physicists. In addition to neutrinos — whose nature, whether or not they are majoranas, is one of the investigative goals of the mega-experiment Dune — another class not of fundamental particles but of quasi-particles or apparent particles has been investigated in the field of condensed matter. These Majorana quasi-particles can emerge as excitations in topological superconductors.

An April 6, 2018 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) press release on EurekAlert, which originated the news item,  reveals more about the Brazilian research (Note: Links have been removed),

A new study by PhD student Luciano Henrique Siliano Ricco with a scholarship from the São Paulo Research Foundation – FAPESP, in collaboration with his supervisor Antonio Carlos Ferreira Seridonio and others, was conducted on the Ilha Solteira campus of São Paulo State University (UNESP) in Brazil and described in an article in Scientific Reports.

“We propose a theoretical device that acts as a thermoelectric tuner – a tuner of heat and charge – assisted by Majorana fermions,” Seridonio said.

The device consists of a quantum dot (QD), represented in the Figure A by the symbol ε1. QDs are often called “artificial atoms.” In this case, the QD is located between two metallic leads at different temperatures.

The temperature difference is fundamental to allowing thermal energy to flow across the QD. A quasi-one-dimensional superconducting wire – called a Kitaev wire after its proponent, Russian physicist Alexei Kitaev, currently a professor at the California Institute of Technology (Caltech) in the US – is connected to the QD.

In this study, the Kitaev wire was ring- or U-shaped and had two majoranas (η1 and η2) at its edges. The majoranas emerge as excitations characterized by zero-energy modes.

“When the QD is coupled to only one side of the wire, the system behaves resonantly with regard to electrical and thermal conductance. In other words, it behaves like a thermoelectric filter,” said the principal investigator for the FAPESP fellowship.

“I should stress that this behavior as a filter for thermal and electrical energy occurs when the two majoranas ‘see’ each other via the wire, but only one of them ‘sees’ the QD in the connection.”

Another possibility investigated by the researchers involved making the QD “see” the two majoranas at the same time by connecting it to both ends of the Kitaev wire.

“By making the QD ‘see’ more of η1 or η2, i.e., by varying the system’s asymmetry, we can use the artificial atom as a tuner, where the thermal or electrical energy that flows through it is redshifted or blueshifted,” Seridonio said (see Figure B for illustrative explanation).

This theoretical paper, he added, is expected to contribute to the development of thermoelectric devices based on Majorana fermions.

Here’s a link to and a citation for the paper,

Tuning of heat and charge transport by Majorana fermions by L. S. Ricco, F. A. Dessotti, I. A. Shelykh, M. S. Figueira & A. C. Seridonio. Scientific Reportsvolume 8, Article number: 2790 (2018) doi:10.1038/s41598-018-21180-9 Published online: 12 February 2018

This paper is open access.

As I prepared to publish this piece I stumbled across a sad Sept. 3, 2018 article about Brazil and its overnight loss of heritage in a fire by Henry Grabar for slate.com (Note: Links have been removed),

On Sunday night, a fire ripped through Brazil’s National Museum in Rio de Janeiro, destroying the country’s most valuable storehouse of natural and anthropological history within hours.

Most of the 20 million items housed inside—including the skull of Luzia, the oldest human remains ever found in the Americas; one of the world’s largest archives of South America’s indigenous cultures; more than 26,000 fossils, 55,000 stuffed birds, and 5 million insect specimens; and a library of more than 500,000 books—are thought to have been destroyed.

The loss is a symptom of a larger problem as Grabar notes in his article.

University of Waterloo (Canada) team combines wearable tech with artificial intelligence (AI) for health

A May 16, 2018 University of Waterloo news release (also on EurekAlert) trumpets the research,

A team of Waterloo researchers found that applying artificial intelligence to the right combination of data retrieved from wearable technology may detect whether your health is failing.

The study, which involved researchers from Waterloo’s Faculties of Applied Health Sciences and Engineering, found that the data from wearable sensors and artificial intelligence that assesses changes in aerobic responses could one day predict whether a person is experiencing the onset of a respiratory or cardiovascular disease.

“The onset of a lot of chronic diseases, including type 2 diabetes and chronic obstructive pulmonary disease, has a direct impact on our aerobic fitness,” said Thomas Beltrame, who led the research while at the University of Waterloo, and is now at the Institute of Computing in University of Campinas in Brazil. “In the near future, we believe it will be possible to continuously check your health, even before you realize that you need medical help.”

The study monitored active, healthy men in their twenties who wore a shirt for four days that incorporated sensors for heart rate, breathing and acceleration. They then compared the readings with laboratory responses and found that it was possible to accurately predict health-related benchmarks during daily activities using only the smart shirt.

“The research found a way to process biological signals and generate a meaningful single number to track fitness,” said Richard Hughson, co-author and kinesiology professor at the Schlegel-University of Waterloo Research Institute for Aging.

Beltrame and Hughson co-authored the study with Alexander Wong, Canada Research Chair in artificial intelligence and medical imaging and an engineering professor at Waterloo. He is affiliated with both the Waterloo Artificial Intelligence Institute and the Schlegel-University of Waterloo Research Institute for Aging. Robert Amelard, of the Schlegel-University of Waterloo Research Institute for Aging, is also a co-author. The study appears in the Journal of Applied Physiology.

“This multi-disciplinary research is a great example of how artificial intelligence can be a potential game-changer for healthcare by turning data into predictive knowledge to help healthcare professionals better understand an individual’s health,” said Wong. “It can have a significant impact on improving quality of life and well-being.”

Carré Technologies developed the smart shirts, called Hexoskin, used in the research.

The team plans to test these systems on mixed ages and genders, and people with health issues to see how people might wear the sensors to gauge whether their health is failing.

I wonder if this is the 2nd try for publicity about this work. Take a look at the publication date,

Extracting aerobic system dynamics during unsupervised activities of daily living using wearable sensor machine learning models by Thomas Beltrame, Robert Amelard, Alexander Wong, and Richard L. Hughson. Journal of Applied Physiology 124 (2)
Volume 124Issue 2February 2018Pages 473-48 https://doi.org/10.1152/japplphysiol.00299.2017 [Published] 23 Feb 2018

This paper is behind a paywall.

Interested parties can find Carré Technologies here.

The Hedy Lamarr of international research: Canada’s Third assessment of The State of Science and Technology and Industrial Research and Development in Canada (2 of 2)

Taking up from where I left off with my comments on Competing in a Global Innovation Economy: The Current State of R and D in Canada or as I prefer to call it the Third assessment of Canadas S&T (science and technology) and R&D (research and development). (Part 1 for anyone who missed it).

Is it possible to get past Hedy?

Interestingly (to me anyway), one of our R&D strengths, the visual and performing arts, features sectors where a preponderance of people are dedicated to creating culture in Canada and don’t spend a lot of time trying to make money so they can retire before the age of 40 as so many of our start-up founders do. (Retiring before the age of 40 just reminded me of Hollywood actresses {Hedy] who found and still do find that work was/is hard to come by after that age. You may be able but I’m not sure I can get past Hedy.) Perhaps our business people (start-up founders) could take a leaf out of the visual and performing arts handbook? Or, not. There is another question.

Does it matter if we continue to be a ‘branch plant’ economy? Somebody once posed that question to me when I was grumbling that our start-ups never led to larger businesses and acted more like incubators (which could describe our R&D as well),. He noted that Canadians have a pretty good standard of living and we’ve been running things this way for over a century and it seems to work for us. Is it that bad? I didn’t have an  answer for him then and I don’t have one now but I think it’s a useful question to ask and no one on this (2018) expert panel or the previous expert panel (2013) seems to have asked.

I appreciate that the panel was constrained by the questions given by the government but given how they snuck in a few items that technically speaking were not part of their remit, I’m thinking they might have gone just a bit further. The problem with answering the questions as asked is that if you’ve got the wrong questions, your answers will be garbage (GIGO; garbage in, garbage out) or, as is said, where science is concerned, it’s the quality of your questions.

On that note, I would have liked to know more about the survey of top-cited researchers. I think looking at the questions could have been quite illuminating and I would have liked some information on from where (geographically and area of specialization) they got most of their answers. In keeping with past practice (2012 assessment published in 2013), there is no additional information offered about the survey questions or results. Still, there was this (from the report released April 10, 2018; Note: There may be some difference between the formatting seen here and that seen in the document),

3.1.2 International Perceptions of Canadian Research
As with the 2012 S&T report, the CCA commissioned a survey of top-cited researchers’ perceptions of Canada’s research strength in their field or subfield relative to that of other countries (Section 1.3.2). Researchers were asked to identify the top five countries in their field and subfield of expertise: 36% of respondents (compared with 37% in the 2012 survey) from across all fields of research rated Canada in the top five countries in their field (Figure B.1 and Table B.1 in the appendix). Canada ranks fourth out of all countries, behind the United States, United Kingdom, and Germany, and ahead of France. This represents a change of about 1 percentage point from the overall results of the 2012 S&T survey. There was a 4 percentage point decrease in how often France is ranked among the top five countries; the ordering of the top five countries, however, remains the same.

When asked to rate Canada’s research strength among other advanced countries in their field of expertise, 72% (4,005) of respondents rated Canadian research as “strong” (corresponding to a score of 5 or higher on a 7-point scale) compared with 68% in the 2012 S&T survey (Table 3.4). [pp. 40-41 Print; pp. 78-70 PDF]

Before I forget, there was mention of the international research scene,

Growth in research output, as estimated by number of publications, varies considerably for the 20 top countries. Brazil, China, India, Iran, and South Korea have had the most significant increases in publication output over the last 10 years. [emphases mine] In particular, the dramatic increase in China’s output means that it is closing the gap with the United States. In 2014, China’s output was 95% of that of the United States, compared with 26% in 2003. [emphasis mine]

Table 3.2 shows the Growth Index (GI), a measure of the rate at which the research output for a given country changed between 2003 and 2014, normalized by the world growth rate. If a country’s growth in research output is higher than the world average, the GI score is greater than 1.0. For example, between 2003 and 2014, China’s GI score was 1.50 (i.e., 50% greater than the world average) compared with 0.88 and 0.80 for Canada and the United States, respectively. Note that the dramatic increase in publication production of emerging economies such as China and India has had a negative impact on Canada’s rank and GI score (see CCA, 2016).

As long as I’ve been blogging (10 years), the international research community (in particular the US) has been looking over its shoulder at China.

Patents and intellectual property

As an inventor, Hedy got more than one patent. Much has been made of the fact that  despite an agreement, the US Navy did not pay her or her partner (George Antheil) for work that would lead to significant military use (apparently, it was instrumental in the Bay of Pigs incident, for those familiar with that bit of history), GPS, WiFi, Bluetooth, and more.

Some comments about patents. They are meant to encourage more innovation by ensuring that creators/inventors get paid for their efforts .This is true for a set time period and when it’s over, other people get access and can innovate further. It’s not intended to be a lifelong (or inheritable) source of income. The issue in Lamarr’s case is that the navy developed the technology during the patent’s term without telling either her or her partner so, of course, they didn’t need to compensate them despite the original agreement. They really should have paid her and Antheil.

The current patent situation, particularly in the US, is vastly different from the original vision. These days patents are often used as weapons designed to halt innovation. One item that should be noted is that the Canadian federal budget indirectly addressed their misuse (from my March 16, 2018 posting),

Surprisingly, no one else seems to have mentioned a new (?) intellectual property strategy introduced in the document (from Chapter 2: Progress; scroll down about 80% of the way, Note: The formatting has been changed),

Budget 2018 proposes measures in support of a new Intellectual Property Strategy to help Canadian entrepreneurs better understand and protect intellectual property, and get better access to shared intellectual property.

What Is a Patent Collective?
A Patent Collective is a way for firms to share, generate, and license or purchase intellectual property. The collective approach is intended to help Canadian firms ensure a global “freedom to operate”, mitigate the risk of infringing a patent, and aid in the defence of a patent infringement suit.

Budget 2018 proposes to invest $85.3 million over five years, starting in 2018–19, with $10 million per year ongoing, in support of the strategy. The Minister of Innovation, Science and Economic Development will bring forward the full details of the strategy in the coming months, including the following initiatives to increase the intellectual property literacy of Canadian entrepreneurs, and to reduce costs and create incentives for Canadian businesses to leverage their intellectual property:

  • To better enable firms to access and share intellectual property, the Government proposes to provide $30 million in 2019–20 to pilot a Patent Collective. This collective will work with Canada’s entrepreneurs to pool patents, so that small and medium-sized firms have better access to the critical intellectual property they need to grow their businesses.
  • To support the development of intellectual property expertise and legal advice for Canada’s innovation community, the Government proposes to provide $21.5 million over five years, starting in 2018–19, to Innovation, Science and Economic Development Canada. This funding will improve access for Canadian entrepreneurs to intellectual property legal clinics at universities. It will also enable the creation of a team in the federal government to work with Canadian entrepreneurs to help them develop tailored strategies for using their intellectual property and expanding into international markets.
  • To support strategic intellectual property tools that enable economic growth, Budget 2018 also proposes to provide $33.8 million over five years, starting in 2018–19, to Innovation, Science and Economic Development Canada, including $4.5 million for the creation of an intellectual property marketplace. This marketplace will be a one-stop, online listing of public sector-owned intellectual property available for licensing or sale to reduce transaction costs for businesses and researchers, and to improve Canadian entrepreneurs’ access to public sector-owned intellectual property.

The Government will also consider further measures, including through legislation, in support of the new intellectual property strategy.

Helping All Canadians Harness Intellectual Property
Intellectual property is one of our most valuable resources, and every Canadian business owner should understand how to protect and use it.

To better understand what groups of Canadians are benefiting the most from intellectual property, Budget 2018 proposes to provide Statistics Canada with $2 million over three years to conduct an intellectual property awareness and use survey. This survey will help identify how Canadians understand and use intellectual property, including groups that have traditionally been less likely to use intellectual property, such as women and Indigenous entrepreneurs. The results of the survey should help the Government better meet the needs of these groups through education and awareness initiatives.

The Canadian Intellectual Property Office will also increase the number of education and awareness initiatives that are delivered in partnership with business, intermediaries and academia to ensure Canadians better understand, integrate and take advantage of intellectual property when building their business strategies. This will include targeted initiatives to support underrepresented groups.

Finally, Budget 2018 also proposes to invest $1 million over five years to enable representatives of Canada’s Indigenous Peoples to participate in discussions at the World Intellectual Property Organization related to traditional knowledge and traditional cultural expressions, an important form of intellectual property.

It’s not wholly clear what they mean by ‘intellectual property’. The focus seems to be on  patents as they are the only intellectual property (as opposed to copyright and trademarks) singled out in the budget. As for how the ‘patent collective’ is going to meet all its objectives, this budget supplies no clarity on the matter. On the plus side, I’m glad to see that indigenous peoples’ knowledge is being acknowledged as “an important form of intellectual property” and I hope the discussions at the World Intellectual Property Organization are fruitful.

As for the patent situation in Canada (from the report released April 10, 2018),

Over the past decade, the Canadian patent flow in all technical sectors has consistently decreased. Patent flow provides a partial picture of how patents in Canada are exploited. A negative flow represents a deficit of patented inventions owned by Canadian assignees versus the number of patented inventions created by Canadian inventors. The patent flow for all Canadian patents decreased from about −0.04 in 2003 to −0.26 in 2014 (Figure 4.7). This means that there is an overall deficit of 26% of patent ownership in Canada. In other words, fewer patents were owned by Canadian institutions than were invented in Canada.

This is a significant change from 2003 when the deficit was only 4%. The drop is consistent across all technical sectors in the past 10 years, with Mechanical Engineering falling the least, and Electrical Engineering the most (Figure 4.7). At the technical field level, the patent flow dropped significantly in Digital Communication and Telecommunications. For example, the Digital Communication patent flow fell from 0.6 in 2003 to −0.2 in 2014. This fall could be partially linked to Nortel’s US$4.5 billion patent sale [emphasis mine] to the Rockstar consortium (which included Apple, BlackBerry, Ericsson, Microsoft, and Sony) (Brickley, 2011). Food Chemistry and Microstructural [?] and Nanotechnology both also showed a significant drop in patent flow. [p. 83 Print; p. 121 PDF]

Despite a fall in the number of parents for ‘Digital Communication’, we’re still doing well according to statistics elsewhere in this report. Is it possible that patents aren’t that big a deal? Of course, it’s also possible that we are enjoying the benefits of past work and will miss out on future work. (Note: A video of the April 10, 2018 report presentation by Max Blouw features him saying something like that.)

One last note, Nortel died many years ago. Disconcertingly, this report, despite more than one reference to Nortel, never mentions the company’s demise.

Boxed text

While the expert panel wasn’t tasked to answer certain types of questions, as I’ve noted earlier they managed to sneak in a few items.  One of the strategies they used was putting special inserts into text boxes including this (from the report released April 10, 2018),

Box 4.2
The FinTech Revolution

Financial services is a key industry in Canada. In 2015, the industry accounted for 4.4%

of Canadia jobs and about 7% of Canadian GDP (Burt, 2016). Toronto is the second largest financial services hub in North America and one of the most vibrant research hubs in FinTech. Since 2010, more than 100 start-up companies have been founded in Canada, attracting more than $1 billion in investment (Moffatt, 2016). In 2016 alone, venture-backed investment in Canadian financial technology companies grew by 35% to $137.7 million (Ho, 2017). The Toronto Financial Services Alliance estimates that there are approximately 40,000 ICT specialists working in financial services in Toronto alone.

AI, blockchain, [emphasis mine] and other results of ICT research provide the basis for several transformative FinTech innovations including, for example, decentralized transaction ledgers, cryptocurrencies (e.g., bitcoin), and AI-based risk assessment and fraud detection. These innovations offer opportunities to develop new markets for established financial services firms, but also provide entry points for technology firms to develop competing service offerings, increasing competition in the financial services industry. In response, many financial services companies are increasing their investments in FinTech companies (Breznitz et al., 2015). By their own account, the big five banks invest more than $1 billion annually in R&D of advanced software solutions, including AI-based innovations (J. Thompson, personal communication, 2016). The banks are also increasingly investing in university research and collaboration with start-up companies. For instance, together with several large insurance and financial management firms, all big five banks have invested in the Vector Institute for Artificial Intelligence (Kolm, 2017).

I’m glad to see the mention of blockchain while AI (artificial intelligence) is an area where we have innovated (from the report released April 10, 2018),

AI has attracted researchers and funding since the 1960s; however, there were periods of stagnation in the 1970s and 1980s, sometimes referred to as the “AI winter.” During this period, the Canadian Institute for Advanced Research (CIFAR), under the direction of Fraser Mustard, started supporting AI research with a decade-long program called Artificial Intelligence, Robotics and Society, [emphasis mine] which was active from 1983 to 1994. In 2004, a new program called Neural Computation and Adaptive Perception was initiated and renewed twice in 2008 and 2014 under the title, Learning in Machines and Brains. Through these programs, the government provided long-term, predictable support for high- risk research that propelled Canadian researchers to the forefront of global AI development. In the 1990s and early 2000s, Canadian research output and impact on AI were second only to that of the United States (CIFAR, 2016). NSERC has also been an early supporter of AI. According to its searchable grant database, NSERC has given funding to research projects on AI since at least 1991–1992 (the earliest searchable year) (NSERC, 2017a).

The University of Toronto, the University of Alberta, and the Université de Montréal have emerged as international centres for research in neural networks and deep learning, with leading experts such as Geoffrey Hinton and Yoshua Bengio. Recently, these locations have expanded into vibrant hubs for research in AI applications with a diverse mix of specialized research institutes, accelerators, and start-up companies, and growing investment by major international players in AI development, such as Microsoft, Google, and Facebook. Many highly influential AI researchers today are either from Canada or have at some point in their careers worked at a Canadian institution or with Canadian scholars.

As international opportunities in AI research and the ICT industry have grown, many of Canada’s AI pioneers have been drawn to research institutions and companies outside of Canada. According to the OECD, Canada’s share of patents in AI declined from 2.4% in 2000 to 2005 to 2% in 2010 to 2015. Although Canada is the sixth largest producer of top-cited scientific publications related to machine learning, firms headquartered in Canada accounted for only 0.9% of all AI-related inventions from 2012 to 2014 (OECD, 2017c). Canadian AI researchers, however, remain involved in the core nodes of an expanding international network of AI researchers, most of whom continue to maintain ties with their home institutions. Compared with their international peers, Canadian AI researchers are engaged in international collaborations far more often than would be expected by Canada’s level of research output, with Canada ranking fifth in collaboration. [p. 97-98 Print; p. 135-136 PDF]

The only mention of robotics seems to be here in this section and it’s only in passing. This is a bit surprising given its global importance. I wonder if robotics has been somehow hidden inside the term artificial intelligence, although sometimes it’s vice versa with robot being used to describe artificial intelligence. I’m noticing this trend of assuming the terms are synonymous or interchangeable not just in Canadian publications but elsewhere too.  ’nuff said.

Getting back to the matter at hand, t he report does note that patenting (technometric data) is problematic (from the report released April 10, 2018),

The limitations of technometric data stem largely from their restricted applicability across areas of R&D. Patenting, as a strategy for IP management, is similarly limited in not being equally relevant across industries. Trends in patenting can also reflect commercial pressures unrelated to R&D activities, such as defensive or strategic patenting practices. Finally, taxonomies for assessing patents are not aligned with bibliometric taxonomies, though links can be drawn to research publications through the analysis of patent citations. [p. 105 Print; p. 143 PDF]

It’s interesting to me that they make reference to many of the same issues that I mention but they seem to forget and don’t use that information in their conclusions.

There is one other piece of boxed text I want to highlight (from the report released April 10, 2018),

Box 6.3
Open Science: An Emerging Approach to Create New Linkages

Open Science is an umbrella term to describe collaborative and open approaches to
undertaking science, which can be powerful catalysts of innovation. This includes
the development of open collaborative networks among research performers, such
as the private sector, and the wider distribution of research that usually results when
restrictions on use are removed. Such an approach triggers faster translation of ideas
among research partners and moves the boundaries of pre-competitive research to
later, applied stages of research. With research results freely accessible, companies
can focus on developing new products and processes that can be commercialized.

Two Canadian organizations exemplify the development of such models. In June
2017, Genome Canada, the Ontario government, and pharmaceutical companies
invested $33 million in the Structural Genomics Consortium (SGC) (Genome Canada,
2017). Formed in 2004, the SGC is at the forefront of the Canadian open science
movement and has contributed to many key research advancements towards new
treatments (SGC, 2018). McGill University’s Montréal Neurological Institute and
Hospital has also embraced the principles of open science. Since 2016, it has been
sharing its research results with the scientific community without restriction, with
the objective of expanding “the impact of brain research and accelerat[ing] the
discovery of ground-breaking therapies to treat patients suffering from a wide range
of devastating neurological diseases” (neuro, n.d.).

This is exciting stuff and I’m happy the panel featured it. (I wrote about the Montréal Neurological Institute initiative in a Jan. 22, 2016 posting.)

More than once, the report notes the difficulties with using bibliometric and technometric data as measures of scientific achievement and progress and open science (along with its cousins, open data and open access) are contributing to the difficulties as James Somers notes in his April 5, 2018 article ‘The Scientific Paper is Obsolete’ for The Atlantic (Note: Links have been removed),

The scientific paper—the actual form of it—was one of the enabling inventions of modernity. Before it was developed in the 1600s, results were communicated privately in letters, ephemerally in lectures, or all at once in books. There was no public forum for incremental advances. By making room for reports of single experiments or minor technical advances, journals made the chaos of science accretive. Scientists from that point forward became like the social insects: They made their progress steadily, as a buzzing mass.

The earliest papers were in some ways more readable than papers are today. They were less specialized, more direct, shorter, and far less formal. Calculus had only just been invented. Entire data sets could fit in a table on a single page. What little “computation” contributed to the results was done by hand and could be verified in the same way.

The more sophisticated science becomes, the harder it is to communicate results. Papers today are longer than ever and full of jargon and symbols. They depend on chains of computer programs that generate data, and clean up data, and plot data, and run statistical models on data. These programs tend to be both so sloppily written and so central to the results that it’s [sic] contributed to a replication crisis, or put another way, a failure of the paper to perform its most basic task: to report what you’ve actually discovered, clearly enough that someone else can discover it for themselves.

Perhaps the paper itself is to blame. Scientific methods evolve now at the speed of software; the skill most in demand among physicists, biologists, chemists, geologists, even anthropologists and research psychologists, is facility with programming languages and “data science” packages. And yet the basic means of communicating scientific results hasn’t changed for 400 years. Papers may be posted online, but they’re still text and pictures on a page.

What would you get if you designed the scientific paper from scratch today? A little while ago I spoke to Bret Victor, a researcher who worked at Apple on early user-interface prototypes for the iPad and now runs his own lab in Oakland, California, that studies the future of computing. Victor has long been convinced that scientists haven’t yet taken full advantage of the computer. “It’s not that different than looking at the printing press, and the evolution of the book,” he said. After Gutenberg, the printing press was mostly used to mimic the calligraphy in bibles. It took nearly 100 years of technical and conceptual improvements to invent the modern book. “There was this entire period where they had the new technology of printing, but they were just using it to emulate the old media.”Victor gestured at what might be possible when he redesigned a journal article by Duncan Watts and Steven Strogatz, “Collective dynamics of ‘small-world’ networks.” He chose it both because it’s one of the most highly cited papers in all of science and because it’s a model of clear exposition. (Strogatz is best known for writing the beloved “Elements of Math” column for The New York Times.)

The Watts-Strogatz paper described its key findings the way most papers do, with text, pictures, and mathematical symbols. And like most papers, these findings were still hard to swallow, despite the lucid prose. The hardest parts were the ones that described procedures or algorithms, because these required the reader to “play computer” in their head, as Victor put it, that is, to strain to maintain a fragile mental picture of what was happening with each step of the algorithm.Victor’s redesign interleaved the explanatory text with little interactive diagrams that illustrated each step. In his version, you could see the algorithm at work on an example. You could even control it yourself….

For anyone interested in the evolution of how science is conducted and communicated, Somers’ article is a fascinating and in depth look at future possibilities.

Subregional R&D

I didn’t find this quite as compelling as the last time and that may be due to the fact that there’s less information and I think the 2012 report was the first to examine the Canadian R&D scene with a subregional (in their case, provinces) lens. On a high note, this report also covers cities (!) and regions, as well as, provinces.

Here’s the conclusion (from the report released April 10, 2018),

Ontario leads Canada in R&D investment and performance. The province accounts for almost half of R&D investment and personnel, research publications and collaborations, and patents. R&D activity in Ontario produces high-quality publications in each of Canada’s five R&D strengths, reflecting both the quantity and quality of universities in the province. Quebec lags Ontario in total investment, publications, and patents, but performs as well (citations) or better (R&D intensity) by some measures. Much like Ontario, Quebec researchers produce impactful publications across most of Canada’s five R&D strengths. Although it invests an amount similar to that of Alberta, British Columbia does so at a significantly higher intensity. British Columbia also produces more highly cited publications and patents, and is involved in more international research collaborations. R&D in British Columbia and Alberta clusters around Vancouver and Calgary in areas such as physics and ICT and in clinical medicine and energy, respectively. [emphasis mine] Smaller but vibrant R&D communities exist in the Prairies and Atlantic Canada [also referred to as the Maritime provinces or Maritimes] (and, to a lesser extent, in the Territories) in natural resource industries.

Globally, as urban populations expand exponentially, cities are likely to drive innovation and wealth creation at an increasing rate in the future. In Canada, R&D activity clusters around five large cities: Toronto, Montréal, Vancouver, Ottawa, and Calgary. These five cities create patents and high-tech companies at nearly twice the rate of other Canadian cities. They also account for half of clusters in the services sector, and many in advanced manufacturing.

Many clusters relate to natural resources and long-standing areas of economic and research strength. Natural resource clusters have emerged around the location of resources, such as forestry in British Columbia, oil and gas in Alberta, agriculture in Ontario, mining in Quebec, and maritime resources in Atlantic Canada. The automotive, plastics, and steel industries have the most individual clusters as a result of their economic success in Windsor, Hamilton, and Oshawa. Advanced manufacturing industries tend to be more concentrated, often located near specialized research universities. Strong connections between academia and industry are often associated with these clusters. R&D activity is distributed across the country, varying both between and within regions. It is critical to avoid drawing the wrong conclusion from this fact. This distribution does not imply the existence of a problem that needs to be remedied. Rather, it signals the benefits of diverse innovation systems, with differentiation driven by the needs of and resources available in each province. [pp.  132-133 Print; pp. 170-171 PDF]

Intriguingly, there’s no mention that in British Columbia (BC), there are leading areas of research: Visual & Performing Arts, Psychology & Cognitive Sciences, and Clinical Medicine (according to the table on p. 117 Print, p. 153 PDF).

As I said and hinted earlier, we’ve got brains; they’re just not the kind of brains that command respect.

Final comments

My hat’s off to the expert panel and staff of the Council of Canadian Academies. Combining two previous reports into one could not have been easy. As well, kudos to their attempts to broaden the discussion by mentioning initiative such as open science and for emphasizing the problems with bibliometrics, technometrics, and other measures. I have covered only parts of this assessment, (Competing in a Global Innovation Economy: The Current State of R&D in Canada), there’s a lot more to it including a substantive list of reference materials (bibliography).

While I have argued that perhaps the situation isn’t quite as bad as the headlines and statistics may suggest, there are some concerning trends for Canadians but we have to acknowledge that many countries have stepped up their research game and that’s good for all of us. You don’t get better at anything unless you work with and play with others who are better than you are. For example, both India and Italy surpassed us in numbers of published research papers. We slipped from 7th place to 9th. Thank you, Italy and India. (And, Happy ‘Italian Research in the World Day’ on April 15, 2018, the day’s inaugural year. In Italian: Piano Straordinario “Vivere all’Italiana” – Giornata della ricerca Italiana nel mondo.)

Unfortunately, the reading is harder going than previous R&D assessments in the CCA catalogue. And in the end, I can’t help thinking we’re just a little bit like Hedy Lamarr. Not really appreciated in all of our complexities although the expert panel and staff did try from time to time. Perhaps the government needs to find better ways of asking the questions.

***ETA April 12, 2018 at 1500 PDT: Talking about missing the obvious! I’ve been ranting on about how research strength in visual and performing arts and in philosophy and theology, etc. is perfectly fine and could lead to ‘traditional’ science breakthroughs without underlining the point by noting that Antheil was a musician, Lamarr was as an actress and they set the foundation for work by electrical engineers (or people with that specialty) for their signature work leading to WiFi, etc.***

There is, by the way, a Hedy-Canada connection. In 1998, she sued Canadian software company Corel, for its unauthorized use of her image on their Corel Draw 8 product packaging. She won.

More stuff

For those who’d like to see and hear the April 10, 2017 launch for “Competing in a Global Innovation Economy: The Current State of R&D in Canada” or the Third Assessment as I think of it, go here.

The report can be found here.

For anyone curious about ‘Bombshell: The Hedy Lamarr Story’ to be broadcast on May 18, 2018 as part of PBS’s American Masters series, there’s this trailer,

For the curious, I did find out more about the Hedy Lamarr and Corel Draw. John Lettice’s December 2, 1998 article The Rgister describes the suit and her subsequent victory in less than admiring terms,

Our picture doesn’t show glamorous actress Hedy Lamarr, who yesterday [Dec. 1, 1998] came to a settlement with Corel over the use of her image on Corel’s packaging. But we suppose that following the settlement we could have used a picture of Corel’s packaging. Lamarr sued Corel earlier this year over its use of a CorelDraw image of her. The picture had been produced by John Corkery, who was 1996 Best of Show winner of the Corel World Design Contest. Corel now seems to have come to an undisclosed settlement with her, which includes a five-year exclusive (oops — maybe we can’t use the pack-shot then) licence to use “the lifelike vector illustration of Hedy Lamarr on Corel’s graphic software packaging”. Lamarr, bless ‘er, says she’s looking forward to the continued success of Corel Corporation,  …

There’s this excerpt from a Sept. 21, 2015 posting (a pictorial essay of Lamarr’s life) by Shahebaz Khan on The Blaze Blog,

6. CorelDRAW:
For several years beginning in 1997, the boxes of Corel DRAW’s software suites were graced by a large Corel-drawn image of Lamarr. The picture won Corel DRAW’s yearly software suite cover design contest in 1996. Lamarr sued Corel for using the image without her permission. Corel countered that she did not own rights to the image. The parties reached an undisclosed settlement in 1998.

There’s also a Nov. 23, 1998 Corel Draw 8 product review by Mike Gorman on mymac.com, which includes a screenshot of the packaging that precipitated the lawsuit. Once they settled, it seems Corel used her image at least one more time.