Tag Archives: Spain

Using natural proteins to grow gold nanoclusters for hybrid bionanomaterials

While there’s a January 10, 2022 news item on Nanowerk, the research being announced was made available online in the Fall of 2021 and is now available in print,

Gold nanoclusters are groups of a few gold atoms with interesting photoluminescent properties. The features of gold nanoclusters depend not only on their structure, but their size and also by the ligands coordinated to them. These inorganic nanomaterials have been used in sensing, biomedicine and optics and their coordination with biomolecules can endow multiple capabilities in biological media.

A research collaboration between the groups of Dr. Juan Cabanillas, Research Professor at IMDEA Nanociencia and Dr. Aitziber L. Cortajarena, Ikerbasque Professor and Principal Investigator at CIC biomaGUNE have explored the use of natural proteins to grow gold nanoclusters, resulting in hybrid bionanomaterials with tunable photoluminescent properties and with a plethora of potential applications.

A January 10, 2022 IMDEA Nanociencia press release, which originated the news item, provides more technical detail about the research,

The nanoclusters –with less than 2 nm in size- differentiate from larger nanoparticles (plasmonic) since they present discrete energy levels coupled optically. The groups of amino acids within the proteins coordinate the gold atoms and allow the groups to be arranged around the gold nanocluster, facilitating the stabilization and adding an extra level of tailoring. These nanoclusters have interesting energy harvesting features. Since the discrete energy levels are optically coupled, the absorption of a photon leads to promotion of an electron to higher levels, which can trigger a photophysical process or a photochemical reaction.  

The results by Cabanillas and Cortajarena groups, published in Advanced Optical Materials and Nano Letters, explore the origin of the photoluminescence in protein-designed gold nanoclusters and shed light into the strong influence of environmental conditions on the nature of luminescence. Nanocluster capping by two types of amino acids (histidine and cysteine) allow for changing the emission spectral range from blue to red, paving the way to tune the optical properties by an appropriate ligand choice. The nature of emission is also changed with capping, from fluorescence to phosphorescence, respectively. The synergistic protein-nanocluster effects on emission are still not clear, and the groups at IMDEA Nanociencia and CIC biomaGUNE are working to elucidate the mechanisms behind. There are potential applications for the aforementioned nanoclusters, in solid state as active medium in laser cavities. Optical gain properties from these nanoclusters are yet to be demonstrated, which could pave the way to a new generation of potentially interesting laser devices. As the combination of gold plus proteins is potentially biocompatible, many potential applications in biomedicine can also be envisaged.

A related publication of the groups in Nano Letters demonstrates that the insertion of tryptophans, amino acids with high electron density, in the vicinity of the nanocluster boosts its photoluminescence quantum efficiency up to 40% in some cases, values relevant for solid state light emission applications. Researchers also observed an antenna effect: the tryptophans can absorb light in a discrete manner and transfer the energy to the cluster. This effect has interest for energy harvesting and for sensing purposes as well.

The proteins through the biocapping enable the synthesis of the nanoclusters and largely improve their quantum efficiency. “The photoluminescence quantum efficiency is largely improved when using the biocapping” Dr. Cabanillas says. He believes this research work means “a new field opening for the tuning of optical properties of nanoclusters through protein engineering, and much work is ahead for the understanding of the amplification mechanism”. Dr. Cortajarena emphasizes “we have already demonstrated the great potential of engineered photoluminescent protein-nanocluster in biomedical and technological fields, and understanding the fundamental emission mechanisms is pivotal for future applications“. A variety of further applications include biosensors, as the protein admits functionalization with recognition molecules, energy harvesting, imaging and photodynamic therapies. Further work is ahead this opening avenue for photophysics research.

This research is a collaboration led by Dr. Juan Cabanillas and Dr. Aitziber L. Cortajarena research groups at IMDEA Nanociencia and CIC biomaGUNE, with contributions from researchers at the Diamond Light Source Ltd. [synchrotron] and DIPC. It has been cofounded by the projects AMAPOLA, NMAT2D, FULMATEN, Atracción de Talento from Comunidad de Madrid and the Severo Ochoa Centre of Excellence award to IMDEA Nanociencia. CIC biomaGUNE acknowledges support by the projects ERC-ProNANO, ERC-NIMM, ProTOOLs and the Maria de Maeztu Units of Excellence Programme.

Here are links to and citations for the papers,

Tuning the Optical Properties of Au Nanoclusters by Designed Proteins by Elena Lopez-Martinez, Diego Gianolio, Saül Garcia-Orrit, Victor Vega-Mayoral, Juan Cabanillas-Gonzalez, Carlos Sanchez-Cano, Aitziber L. Cortajarena. Advanced Optical Materials Volume 10, Issue 1 January 4, 2022 2101332 DOI: https://doi.org/10.1002/adom.202101332 First published: 31 October 2021

This paper is open access.

Boosting the Photoluminescent Properties of Protein-Stabilized Gold Nanoclusters through Protein Engineering by Antonio Aires, Ahmad Sousaraei, Marco Möller, Juan Cabanillas-Gonzalez, and Aitziber L. Cortajarena. Nano Lett. 2021, 21, 21, 9347–9353 DOI: https://doi.org/10.1021/acs.nanolett.1c03768 Publication Date: November 1, 2021 Copyright © 2021 American Chemical Society

This paper is behind a paywall.

Not being familiar with either of the two research institutions mentioned in the press release, I did a little digging.

Here’s a little information about IMDEA Nanociencia (IMDEA Nanoscience Institute), from its Wikipedia entry, Note: All links have been removed,

IMDEA Nanoscience Institute is a private non-profit foundation within the IMDEA Institutes network, created in 2006-2007 as a result of collaboration agreement between the Community of Madrid and Spanish Ministry of Education and Science. The foundation manages IMDEA-Nanoscience Institute,[1] a scientific centre dedicated to front-line research in nanoscience, nanotechnology and molecular design and aiming at transferable innovations and close contact with industries. IMDEA Nanoscience is a member of the Campus of International excellence, a consortium of research institutes promoted by the Autonomous University of Madrid and Spanish National Research Council (UAM/CSIC).[2]

As for CIC biomaGUNE, here’s more from its institutional profile on the science.eus website,

The Centre for Cooperative Research in Biomaterials-CIC biomaGUNE, located in San Sebastian (Spain), was officially opened in December 2006. CIC biomaGUNE is a non-profit research organization created to promote scientific research and technological innovation at the highest levels in the Basque Country following the BioBasque policy in order to create a new business sector based on biosciences. Established by the Department of Industry, Technology & Innovation of the Government of the Autonomous Community of the Basque Country, CIC biomaGUNE constitutes one of the Centres of the CIC network, the largest Basque Country research network on specific strategic areas, having the mission to contribute to the economical and social development of the country through the generation of knowledge and speeding up the process that leads to technological innovation.

Science policy updates (INGSA in Canada and SCWIST)

I had just posted my Aug. 30, 2021 piece (4th International Conference on Science Advice to Governments (INGSA2021) August 30 – September 2, 2021) when the organization issued a news release, which was partially embargoed. By the time this is published (after 8 am ET on Wednesday, Sept. 1, 2021), the embargo will have lifted and i can announce that Rémi Quirion, Chief Scientist of Québec (Canada), has been selected to replace Sir Peter Gluckman (New Zealand) as President of INGSA.

Here’s the whole August 30, 2021 International Network for Government Science Advice (INGSA) news release on EurekAlert, Note: This looks like a direct translation from a French language news release, which may account for some unusual word choices and turns of phrase,

What? 4th International Conference on Science Advice to Governments, INGSA2021.

Where? Palais des Congrès de Montréal, Québec, Canada and online at www.ingsa2021.org

When? 30 August – 2 September, 2021.

CONTEXT: The largest ever independent gathering of interest groups, thought-leaders, science advisors to governments and global institutions, researchers, academics, communicators and diplomats is taking place in Montreal and online. Organized by Prof Rémi Quirion, Chief Scientist of Québec, speakers from over 50 countries[1] from Brazil to Burkina Faso and from Ireland to Indonesia, plus over 2000 delegates from over 130 countries, will spotlight what is really at stake in the relationship between science and policy-making, both during crises and within our daily lives. From the air we breathe, the food we eat and the cars we drive, to the medical treatments or the vaccines we take, and the education we provide to children, this relationship, and the decisions it can influence, matter immensely.  

Prof Rémi Quirion, Conference Organizer, Chief Scientist of Québec and incoming President of INGSA added: “For those of us who believe wholeheartedly in evidence and the integrity of science, the past 18 months have been challenging. Information, correct and incorrect, can spread like a virus. The importance of open science and access to data to inform our UN sustainable development goals discussions or domestically as we strengthen the role of cities and municipalities, has never been more critical. I have no doubt that this transparent and honest platform led from Montréal will act as a carrier-wave for greater engagement”.

Chief Science Advisor of Canada and Conference co-organizer, Dr Mona Nemer, stated that: “Rapid scientific advances in managing the Covid pandemic have generated enormous public interest in evidence-based decision making. This attention comes with high expectations and an obligation to achieve results. Overcoming the current health crisis and future challenges will require global coordination in science advice, and INGSA is well positioned to carry out this important work. Canada and our international peers can benefit greatly from this collaboration.”

Sir Peter Gluckman, founding Chair of INGSA stated that: “This is a timely conference as we are at a turning point not just in the pandemic, but globally in our management of longer-term challenges that affect us all. INGSA has helped build and elevate open and ongoing public and policy dialogue about the role of robust evidence in sound policy making”.

He added that: “Issues that were considered marginal seven years ago when the network was created are today rightly seen as central to our social, environmental and economic wellbeing. The pandemic highlights the strengths and weaknesses of evidence-based policy-making at all levels of governance. Operating on all continents, INGSA demonstrates the value of a well-networked community of emerging and experienced practitioners and academics, from countries at all levels of development. Learning from each other, we can help bring scientific evidence more centrally into policy-making. INGSA has achieved much since its formation in 2014, but the energy shown in this meeting demonstrates our potential to do so much more”.

Held previously in Auckland 2014, Brussels 2016, Tokyo 2018 and delayed for one year due to Covid, the advantage of the new hybrid and virtual format is that organizers have been able to involve more speakers, broaden the thematic scope and offer the conference as free to view online, reaching thousands more people. Examining the complex interactions between scientists, public policy and diplomatic relations at local, national, regional and international levels, especially in times of crisis, the overarching INGSA2021 theme is: “Build back wiser: knowledge, policy & publics in dialogue”.

The first three days will scrutinize everything from concrete case-studies outlining successes and failures in our advisory systems to how digital technologies and AI are reshaping the profession itself. The final day targets how expertize and action in the cultural context of the French-speaking world is encouraging partnerships and contributing to economic and social development. A highlight of the conference is the 2 September announcement of a new ‘Francophonie Science Advisory Network’.       

Prof. Salim Abdool Karim, a member of the World Health Organization’s Science Council, and the face of South Africa’s Covid-19 science, speaking in the opening plenary outlined that: “As a past anti-apartheid activist now providing scientific advice to policy-makers, I have learnt that science and politics share common features. Both operate at the boundaries of knowledge and uncertainty, but approach problems differently. We scientists constantly question and challenge our assumptions, constantly searching for empiric evidence to determine the best options. In contrast, politicians are most often guided by the needs or demands of voters and constituencies, and by ideology”.

He added: “What is changing is that grass-roots citizens worldwide are no longer ill-informed and passive bystanders. And they are rightfully demanding greater transparency and accountability. This has brought the complex contradictions between evidence and ideology into the public eye. Covid-19 is not just a disease, its social fabric exemplifies humanity’s interdependence in slowing global spread and preventing new viral mutations through global vaccine equity. This starkly highlights the fault-lines between the rich and poor countries, especially the maldistribution of life-saving public health goods like vaccines. I will explore some of the key lessons from Covid-19 to guide a better response to the next pandemic”.

Speaking on a panel analysing different advisory models, Prof. Mark Ferguson, Chair of the European Innovation Council’s Advisory Board and Chief Science Advisor to the Government of Ireland, sounded a note of optimism and caution in stating that: “Around the world, many scientists have become public celebrities as citizens engage with science like never before. Every country has a new, much followed advisory body. With that comes tremendous opportunities to advance the status of science and the funding of scientific research. On the flipside, my view is that we must also be mindful of the threat of science and scientists being viewed as a political force”.

Strength in numbers

What makes the 4th edition of this biennial event stand out is the perhaps never-before assembled range of speakers from all continents working at the boundary between science, society and policy willing to make their voices heard. In a truly ‘Olympics’ approach to getting all stakeholders on-board, organisers succeeded in involving, amongst others, the UN Office for Disaster Risk Reduction, the United Nations Development Programme, UNESCO and the OECD. The in-house science services of the European Commission and Parliament, plus many country-specific science advisors also feature prominently.

As organisers foster informed debate, we get a rare glimpse inside the science advisory worlds of the Comprehensive Nuclear Test Ban Treaty Organisation, the World Economic Forum and the Global Young Academy to name a few. From Canadian doctors, educators and entrepreneurs and charitable foundations like the Welcome Trust, to Science Europe and media organisations, the programme is rich in its diversity. The International Organisation of the Francophonie and a keynote address by H.E. Laurent Fabius, President of the Constitutional Council of the French Republic are just examples of two major draws on the final day dedicated to spotlighting advisory groups working through French. 

INGSA’s Elections: New Canadian President and Three Vice Presidents from Chile, Ethiopia, UK

The International Network for Government Science Advice has recently undertaken a series of internal reforms intended to better equip it to respond to the growing demands for support from its international partners, while realising the project proposals and ideas of its members.

Part of these reforms included the election in June, 2021 of a new President replacing Sir Peter Gluckman (2014 – 2021) and the creation of three new Vice President roles.

These results will be announced at 13h15 on Wednesday, 1st September during a special conference plenary and awards ceremony. While noting the election results below, media are asked to respect this embargo.

Professor Rémi Quirion, Chief Scientist of Québec (Canada), replaces Sir Peter Gluckman (New Zealand) as President of INGSA.

Professor Claire Craig (United Kingdom), CBE, Provost of Queen’s College Oxford and a member of the UK government’s AI Council, has been elected by members as the inaugural Vice President for Evidence.

Professor Binyam Sisay Mendisu (Egypt), PhD, Lecture at the University of Addis Ababa and Programme Advisor, UNESCO Institute for Building Capacity in Africa, has been elected by members as the inaugural Vice President for Capacity Building.

Professor Soledad Quiroz Valenzuela (Chile), Science Advisor on Climate Change to the Ministry of Science, Technology, Knowledge and Innovation of the government of Chile, has been elected by members as the Vice President for Policy.

Satellite Events: From 7 – 9 September, as part of INGSA2021, the conference is partnering with local,  national and international organisations to ignite further conversations about the science/policy/society interface. Six satellite events are planned to cover everything from climate science advice and energy policy, open science and publishing during a crisis, to the politicisation of science and pre-school scientific education. International delegates are equally encouraged to join in online. 

About INGSA: Founded in 2014 with regional chapters in Africa, Asia and Latin America and the Caribbean, INGSA has quicky established an important reputation as aa collaborative platform for policy exchange, capacity building and research across diverse global science advisory organisations and national systems. Currently, over 5000 individuals and institutions are listed as members. Science communicators and members of the media are warmly welcomed to join.

As the body of work detailed on its website shows (www.ingsa.org) through workshops, conferences and a growing catalogue of tools and guidance, the network aims to enhance the global science-policy interface to improve the potential for evidence-informed policy formation at sub-national, national and transnational levels. INGSA operates as an affiliated body of the International Science Council which acts as trustee of INGSA funds and hosts its governance committee. INGSA’s secretariat is based in Koi Tū: The Centre for Informed Futures at the University of Auckland in New Zealand.

Conference Programme: 4th International Conference on Science Advice to Government (ingsa2021.org)

Newly released compendium of Speaker Viewpoints: Download Essays From The Cutting Edge Of Science Advice – Viewpoints

[1] Argentina, Australia, Austria, Barbados, Belgium, Benin, Brazil, Burkina Faso, Cameroon, Canada, Chad, Colombia, Costa Rica, Côte D’Ivoire, Denmark, Estonia, Finland, France, Germany, Hong Kong, Indonesia, Ireland, Japan, Lebanon, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, New Zealand, Pakistan, Papua New Guinea, Rwanda, Senegal, Singapore, Slovakia, South Africa, Spain, Sri Lanka, Sweden, Switzerland, Thailand, UK, USA. 

Society for Canadian Women in Science and Technology (SCWIST)

As noted earlier this year in my January 28, 2021 posting, it’s SCWIST’s 40th anniversary and the organization is celebrating with a number of initiatives, here are some of the latest including as talk on science policy (from the August 2021 newsletter received via email),

SCWIST “STEM Forward Project”
Receives Federal Funding

SCWIST’s “STEM Forward for Economic Prosperity” project proposal was among 237 projects across the country to receive funding from the $100 million Feminist Response Recovery Fund of the Government of Canada through the Women and Gender Equality Canada (WAGE) federal department.

Read more. 

iWIST and SCWIST Ink Affiliate MOU [memorandum of understanding]

Years in planning, the Island Women in Science and Technology (iWIST) of Victoria, British Columbia and SCWIST finally signed an Affiliate MOU (memorandum of understanding) on Aug 11, 2021.

The MOU strengthens our commitment to collaborate on advocacy (e.g. grants, policy and program changes at the Provincial and Federal level), events (networking, workshops, conferences), cross promotion ( event/ program promotion via digital media), and membership growth (discounts for iWIST members to join SCWIST and vice versa).

Dr. Khristine Carino, SCWIST President, travelled to Victoria to sign the MOU in person. She was invited as an honoured guest to the iWIST annual summer picnic by Claire Skillen, iWIST President. Khristine’s travel expenses were paid from her own personal funds.

Discovery Foundation x SBN x SCWIST Business Mentorship Program: Enhancing Diversity in today’s Biotechnology Landscape

The Discovery Foundation, Student Biotechnology Network, and Society for Canadian Women in Science and Technology are proud to bring you the first-ever “Business Mentorship Program: Enhancing Diversity in today’s Biotechnology Landscape”. 

The Business Mentorship Program aims to support historically underrepresented communities (BIPOC, Women, LGBTQIAS+ and more) in navigating the growth of the biotechnology industry. The program aims to foster relationships between individuals and professionals through networking and mentorship, providing education and training through workshops and seminars, and providing 1:1 consultation with industry leaders. Participants will be paired with mentors throughout the week and have the opportunity to deliver a pitch for the chance to win prizes at the annual Building Biotechnology Expo. 

This is a one week intensive program running from September 27th – October 1st, 2021 and is limited to 10 participants. Please apply early. 


September 10

Art of Science and Policy-Making Go Together

Science and policy-making go together. Acuitas’ [emphasis mine] Molly Sung shares her journey and how more scientists need to engage in this important area.

September 23

Au-delà de l’apparence :

des femmes de courage et de résilience en STIM

Dans le cadre de la semaine de l’égalité des sexes au Canada, ce forum de la division québécoise de la Société pour les femmes canadiennes en science et technologie (la SCWIST) mettra en vedette quatre panélistes inspirantes avec des parcours variés qui étudient ou travaillent en science, technologie, ingénierie et mathématiques (STIM) au Québec. Ces femmes immigrantes ont laissé leurs proches et leurs pays d’origine pour venir au Québec et contribuer activement à la recherche scientifique québécoise. 


The ‘Art and Science Policy-Making Go Together’ talk seems to be aimed at persuasion and is not likely to offer any insider information as to how the BC life sciences effort is progressing. For a somewhat less rosy view of science and policy efforts, you can check out my August 23, 2021 posting, Who’s running the life science companies’ public relations campaign in British Columbia (Vancouver, Canada)?; scroll down to ‘The BC biotech gorillas’ subhead for more about Acuitas and some of the other life sciences companies in British Columbia (BC).

For some insight into how competitive the scene is here in BC, you can see my August 20, 2021 posting (Getting erased from the mRNA/COVID-19 story) about Ian MacLachlan.

You can check out more at the SCWIST website and I’m not sure when the August issue will be placed there but they do have a Newsletter Archive.

4th International Conference on Science Advice to Governments (INGSA2021) August 30 – September 2, 2021

What I find most exciting about this conference is the range of countries being represented. At first glance, I’ve found Argentina, Thailand, Senegal, Ivory Coast, Costa Rica and more in a science meeting being held in Canada. Thank you to the organizers and to the organization International Network for Government Science Advice (INGSA)

As I’ve noted many times here in discussing the science advice we (Canadians) get through the Council of Canadian Academies (CCA), there’s far too much dependence on the same old, same old countries for international expertise. Let’s hope this meeting changes things.

The conference (with the theme Build Back Wiser: Knowledge, Policy and Publics in Dialogue) started on Monday, August 30, 2021 and is set to run for four days in Montréal, Québec. and as an online event The Premier of Québec, François Legault, and Mayor of Montréal, Valérie Plante (along with Peter Gluckman, Chair of INGSA and Rémi Quirion, Chief Scientist of Québec; this is the only province with a chief scientist) are there to welcome those who are present in person.

You can find a PDF of the four day programme here or go to the INGSA 2021 website for the programme and more. Here’s a sample from the programme of what excited me, from Day 1 (August 30, 2021),

8:45 | Plenary | Roundtable: Reflections from Covid-19: Where to from here?

Mona Nemer – Chief Science Advisor of Canada

Joanne Liu – Professor, School of Population and Global Health, McGill University, Quebec, Canada
Chor Pharn Lee – Principal Foresight Strategist at Centre for Strategic Futures, Prime Minister’s Office, Singapore
Andrea Ammon – Director of the European Centre for Disease Prevention and Control, Sweden
Rafael Radi – President of the National Academy of Sciences; Coordinator of Scientific Honorary Advisory Group to the President on Covid-19, Uruguay

9:45 | Panel: Science advice during COVID-19: What factors made the difference?


Romain Murenzi – Executive Director, The World Academy of Sciences (TWAS), Italy


Stephen Quest – Director-General, European Commission’s Joint Research Centre (JRC), Belgium
Yuxi Zhang – Postdoctoral Research Fellow, Blavatnik School of Government, University of Oxford, United Kingdom
Amadou Sall – Director, Pasteur Institute of Dakar, Senegal
Inaya Rakhmani – Director, Asia Research Centre, Universitas Indonesia

One last excerpt, from Day 2 (August 31, 2021),

Studio Session | Panel: Science advice for complex risk assessment: dealing with complex, new, and interacting threats

Eeva Hellström – Senior Lead, Strategy and Foresight, Finnish Innovation Fund Sitra, Finland

Albert van Jaarsveld – Director General and Chief Executive Officer, International Institute for Applied Systems Analysis, Austria
Abdoulaye Gounou – Head, Benin’s Office for the Evaluation of Public Policies and Analysis of Government Action
Catherine Mei Ling Wong – Sociologist, LRF Institute for the Public Understanding of Risk, National University of Singapore
Andria Grosvenor – Deputy Executive Director (Ag), Caribbean Disaster Emergency Management Agency, Barbados

Studio Session | Innovations in Science Advice – Science Diplomacy driving evidence for policymaking

Mehrdad Hariri – CEO and President of the Canadian Science Policy Centre, Canada

Primal Silva – Canadian Food Inspection Agency’s Chief Science Operating Officer, Canada
Zakri bin Abdul Hamid – Chair of the South-East Asia Science Advice Network (SEA SAN); Pro-Chancellor of Multimedia University in Malaysia
Christian Arnault Emini – Senior Economic Adviser to the Prime Minister’s Office in Cameroon
Florence Gauzy Krieger and Sebastian Goers – RLS-Sciences Network [See more about RLS-Sciences below]
Elke Dall and Angela Schindler-Daniels – European Union Science Diplomacy Alliance
Alexis Roig – CEO, SciTech DiploHub – Barcelona Science and Technology Diplomacy Hub, Spain

RLS-Sciences (RLS-Sciences Network) has this description for itself on the About/Background webpage,

RLS-Sciences works under the framework of the Regional Leaders Summit. The Regional Leaders Summit (RLS) is a forum comprising seven regional governments (state, federal state, or provincial), which together represent approximately one hundred eighty million people across five continents, and a collective GDP of three trillion USD. The regions are: Bavaria (Germany), Georgia (USA), Québec (Canada), São Paulo (Brazil), Shandong (China), Upper Austria (Austria), and Western Cape (South Africa). Since 2002, the heads of government for these regions have met every two years for a political summit. These summits offer the RLS regions an opportunity for political dialogue.

Getting back to the main topic of this post, INGSA has some satellite events on offer, including this on Open Science,

Open Science: Science for the 21st century |

Science ouverte : la science au XXIe siècle

Thursday September 9, 2021; 11am-2pm EST |
Jeudi 9 septembre 2021, 11 h à 14 h (HNE).

Places Limited – Registrations Required – Click to register now

This event will be in English and French (using simultaneous translation)  | 
Cet événement se déroulera en anglais et en français (traduction simultanée)

In the past 18 months we have seen an unprecedented level of sharing as medical scientists worked collaboratively and shared data to find solutions to the COVID-19 pandemic. The pandemic has accelerated the ongoing cultural shift in research practices towards open science. 

This acceleration of the discovery/research process presents opportunities for institutions and governments to develop infrastructure, tools, funding, policies, and training to support, promote, and reward open science efforts. It also presents new opportunities to accelerate progress towards the UN Agenda 2030 Sustainable Development Goals through international scientific cooperation.

At the same time, it presents new challenges: rapid developments in open science often outpace national open science policies, funding, and infrastructure frameworks. Moreover, the development of international standard setting instruments, such as the future UNESCO Recommendation on Open Science, requires international harmonization of national policies, the establishment of frameworks to ensure equitable participation, and education, training, and professional development.

This 3-hour satellite event brings together international and national policy makers, funders, and experts in open science infrastructure to discuss these issues. 

The outcome of the satellite event will be a summary report with recommendations for open science policy alignment at institutional, national, and international levels.

The event will be hosted on an events platform, with simultaneous interpretation in English and French.  Participants will be able to choose which concurrent session they participate in upon registration. Registration is free but will be closed when capacity is reached.

This satellite event takes place in time for an interesting anniversary. The Montreal Neurological Institute (MNI), also known as Montreal Neuro, declared itself as Open Science in 2016, the first academic research institute (as far as we know) to do so in the world (see my January 22, 2016 posting for details about their open science initiative and my December 19, 2016 posting for more about their open science and their decision to not pursue patents for a five year period).

The Open Science satellite event is organized by:

The Canadian Commission for UNESCO [United Nations Educational, Scientific and Cultural Organization],

The Neuro (Montreal Neurological Institute-Hospital),

The Knowledge Equity Lab [Note: A University of Toronto initiative with Leslie Chan as director, this website is currently under maintenance]

That’s all folks (for now)!

Mite silk as the basis for a new nanobiomaterial

For the record, this is spider mite silk (I have many posts about spider silk and its possible applications on this blog; just search ‘spider silk’)..

The international collaborative team includes a Canadian university in combination with a Spanish university and a Serbian university. The composition of the team is one I haven’t seen here before. From a December 17, 2020 news item on phys.org (Note: A link has been removed),

An international team of researchers has developed a new nanomaterial from the silk produced by the Tetranychus lintearius mite. This nanomaterial has the ability to penetrate human cells without damaging them and, therefore, has “promising biomedical properties”.

The Nature Scientific Reports journal has published an article by an international scientific team led by Miodrag Grbiç, a researcher from the universities of La Rioja (Spain), Western Ontario (Canada) and Belgrade (Serbia), in its latest issue entitled “The silk of gorse spider mite Tetranychus lintearius represents a novel natural source of nanoparticles and biomaterials.”

In it, researchers from the Murcian Institute for Agricultural and Food Research and Development (IMIDA), the Barcelona Institute of Photonic Sciences, the University of Western Ontario (Canada), the University of Belgrade (Serbia) and the University of La Rioja describe the discovery and characterisation of this mite silk. They also demonstrate its great potential as a source of nanoparticles and biomaterials for medical and technological uses.

A December 17, 2020 Universidad de La Rioja press release (also on EurekAlert), which originated the news item, further explains the research,

The interest of this new material, which is more resistant than steel, ultra flexible, nano-sized, biodegradable, biocompatible and has an excellent ability to penetrate human cells without damaging them, lies in its natural character and its size (a thousand times smaller than human hair), which facilitates cell penetration.

These characteristics are ideal for use in pharmacology and biomedicine since it is biocompatible with organic tissues (stimulates cell proliferation without producing toxicity) and, in principle, biodegradable due to its protein structure (it does not produce residues).

Researcher Miodrag Grbi?, who heads the international group that has researched this mite silk, highlights “its enormous potential for biomedical applications, as thanks to its size it is able to easily penetrate both healthy and cancerous human cells”, which makes it ideal for transporting drugs in cancer therapies, as well as for the development of biosensors to detect pathogens and viruses.


Tetranychus lintearius is an endemic mite from the European Atlantic coast that feeds exclusively on gorse (Ulex europaeus). It is around 0.3 mm in size, making it smaller than the comma on a keyboard, while the strength of its silk is twice as high as standard spider silk.

It is a very rare species that has only been found so far in the municipality of Valgañón (La Rioja, Spain), in Sierra de la Demanda. It was located thanks to the collaboration of Rosario García, a botanist and former dean of the Faculty of Science and Technology at the University of La Rioja, which is why researchers call it “the Rioja bug” (“El Bicho Riojano”).

The resistance of the silk produced by Tetranychus lintearius is twice that of spider silk, a standard material used for this type of research, and stronger than steel. It also has advantages over the fibres secreted by the silkworm due to its higher Young’s modulus, its electrical charge and its smaller size. These characteristics, along with its lightness, make it a promising natural nanomaterial for technological uses.

This finding is the result of work carried out by the international group of researchers led by Miodrag Grbi?, who sequenced the genome of the red spider Tetranychus urticae in 2011, publishing the results in Nature: https://www.nature.com/articles/nature10640.

Unlike the red spider (Tetranychus urticae), the gorse mite (Tetranychus lintearius) produces a large amount of silk. It has been reared in the laboratories of the Department of Agriculture and Food of the University of La Rioja, under the care of Professor Ignacio Pérez Moreno, allowing research to continue. Red spider silk is difficult to handle and has a lower production rate.

Here’s a link to and a citation for the 2020 paper,

The silk of gorse spider mite Tetranychus lintearius represents a novel natural source of nanoparticles and biomaterials by Antonio Abel Lozano-Pérez, Ana Pagán, Vladimir Zhurov, Stephen D. Hudson, Jeffrey L. Hutter, Valerio Pruneri, Ignacio Pérez-Moreno, Vojislava Grbic’, José Luis Cenis, Miodrag Grbic’ & Salvador Aznar-Cervantes. Scientific Reports volume 10, Article number: 18471 (2020) DOI: https://doi.org/10.1038/s41598-020-74766-7 Published: 28 October 2020

This paper is open access.

Natural nanodiamonds found in the ocean

An Oct. 16, 2020 news item on phys.org announces research that contradicts a common belief about how diamonds are formed ,

Natural diamonds can form through low pressure and temperature geological processes on Earth, as stated in an article published in the journal Geochemical Perspectives Letters. The newfound mechanism, far from the classic view on the formation of diamonds under ultra-high pressure, is confirmed in the study, which draws on the participation of experts from the Mineral Resources Research Group of the Faculty of Earth Sciences of the University of Barcelona (UB).

Other participants in the study are the experts from the Institute of Nanoscience and Nanotechnology of the UB (IN2UB), the University of Granada (UGR), the Andalusian Institute of Earth Sciences (IACT), the Institute of Ceramics and Glass (CSIC), and the National Autonomous University of Mexico (UNAM). The study has been carried out within the framework of the doctoral thesis carried out by researcher Núria Pujol-Solà (UB), first author of the article, under the supervision of researchers Joaquín A. Proenza (UB) and Antonio García-Casco (UGR).

An Oct. 9, 2020 University of Barcelona (UB) press release (also on EurekAlert but published Oct. 16, 2020), which originated the news item, further explains the research,

A symbol of luxury and richness, the diamond (from the Greek αδ?μας, “invincible”) is the most valuable gem and the toughest mineral (value of 10 in Mohs scale). It formed by chemically pure carbon, and according to the traditional hypothesis, it crystalizes the cubic system under ultra-high-pressure conditions at great depths in the Earth’s mantle.

The study confirms for the first time the formation of the natural diamond under low pressures in oceanic rocks in the Moa-Baracoa Ophiolitic Massif, in Cuba. This great geological structure is in the north-eastern side of the island and is formed by ophiolites, representative rocks of the Oceanic lithosphere.

These oceanic rocks were placed on the continental edge of North America during the collision of the Caribbean oceanic island arch, between 70 and 40 million years ago. “During its formation in the abysmal marine seafloors, in the cretaceous period -about 120 million years ago-, these oceanic rocks underwent mineral alterations due to marine water infiltrations, a process that led to small fluid inclusions inside the olivine, the most common mineral in this kind of rock”, note Joaquín A. Proenza, member of the Department of Mineralogy, Petrology and Applied Geology at the UB and principal researcher of the project in which the article appears, and Antonio García-Casco, from the Department of Mineralogy and Petrology of the UGR.

“These fluid inclusions contain nanodiamonds -of about 200 and 300 nanometres-, apart from serpentine, magnetite, metallic silicon and pure methane. All these materials have formed under low pressure (<200 MPa) and temperature (<350 ºC), during the olivine alteration that contains fluid inclusions”, add the researchers.

“Therefore, this is the first description of ophiolitic diamond formed under low pressure and temperature, whose formation under natural processes does not bear any doubts”, they highlight.

Diamonds formed under low pressure and temperature

It is notable to bear in mind that the team published, in 2019, a first description of the formation of ophiolitic diamonds under low pressure conditions (Geology), a study carried out as part of the doctoral thesis by the UB researcher Júlia Farré de Pablo, supervised by Joaquín A. Proenza and the UGR professor José María González Jiménez. This study was highly debated on among the members of the international scientific community.

In the published article in Geochemical Perspectives Letters, a journal of the European Association of Geochemistry, the experts detected the nanodiamonds in small fluid inclusions under the surface of the samples. The finding was carried out by using the confocal Raman maps and using focused ion beams (FIB), combined with transmission electron microscopy (FIB-TEM). This is how they could confirm the presence of the diamond in the depth of the sample, and therefore, the formation of a natural diamond under low pressure in exhumed oceanic rocks. The Scientific and Technological Centres of the UB (CCiTUB) have taken part in this study, among other infrastructures supporting the country.

In this case, the study focuses its debate on the validity of some geodynamic models that, based on the presence of ophiolite diamonds, imply circulation in the mantle and large-scale lithosphere recycling. For instance, the ophiolitic diamond was thought to reflect the passing of ophiolitic rocks over the deep earth’s mantle up to the transition area (210-660 km deep) before settling into a normal ophiolite formed under low pressure (~10 km deep).

According to the experts, the low state of oxidation in this geological system would explain the formation of nano-çdiamonds instead of graphite -which would be expected under physical and chemical formation conditions of fluid inclusions.

The study counted on the support from the former Ministry for Economy and Competitiveness (MINECO), the Ramón y Cajal Program and the EU European Regional Development Fund (ERDF).

The researchers have an image showing inclusions which contain nanodiamonds,

Caption: The fluid inclusions inside the olivine contain nanodiamonds, apart from serpentine, magnetite, metallic silicon and pure methane.. Credit: UNIVERSITY OF BARCELONA

Here`s a link to and a citation for the paper,

Diamond forms during low pressure serpentinisation of oceanic lithosphere by
N. Pujol-Solà, A. Garcia-Casco, J.A. Proenza, J.M. González-Jiménez, A. del Campo, V. Colás, À. Canals, A. Sánchez-Navas, J. Roqué-Rosell. Geochemical Perspectives Letters v15 DOI: 10.7185/geochemlet.2029 Published 10 September 2020

This paper is open access.

Nanodevices show (from the inside) how cells change

Embryo cells + nanodevices from University of Bath on Vimeo.

Caption: Five mouse embryos, each containing a nanodevice that is 22-millionths of a metre long. The film begins when the embryos are 2-hours old and continues for 5 hours. Each embryo is about 100-millionths of a metre in diameter. Credit: Professor Tony Perry

Fascinating, yes? As I often watch before reading the caption, these were mysterious grey blobs moving around was my first impression. Given the headline for the May 26, 2020 news item on ScienceDaily, I was expecting the squarish-shaped devices inside,

For the first time, scientists have introduced minuscule tracking devices directly into the interior of mammalian cells, giving an unprecedented peek into the processes that govern the beginning of development.

This work on one-cell embryos is set to shift our understanding of the mechanisms that underpin cellular behaviour in general, and may ultimately provide insights into what goes wrong in ageing and disease.

The research, led by Professor Tony Perry from the Department of Biology and Biochemistry at the University of Bath [UK], involved injecting a silicon-based nanodevice together with sperm into the egg cell of a mouse. The result was a healthy, fertilised egg containing a tracking device.

This image looks to have been enhanced with colour,

Fluorescence of an embryo containing a nanodevice. Courtesy: University of Bath

A May 25, 2020 University of Bath press release (also on EurekAlert but published May 26, 2020)

The tiny devices are a little like spiders, complete with eight highly flexible ‘legs’. The legs measure the ‘pulling and pushing’ forces exerted in the cell interior to a very high level of precision, thereby revealing the cellular forces at play and showing how intracellular matter rearranged itself over time.

The nanodevices are incredibly thin – similar to some of the cell’s structural components, and measuring 22 nanometres, making them approximately 100,000 times thinner than a pound coin. This means they have the flexibility to register the movement of the cell’s cytoplasm as the one-cell embryo embarks on its voyage towards becoming a two-cell embryo.

“This is the first glimpse of the physics of any cell on this scale from within,” said Professor Perry. “It’s the first time anyone has seen from the inside how cell material moves around and organises itself.”


The activity within a cell determines how that cell functions, explains Professor Perry. “The behaviour of intracellular matter is probably as influential to cell behaviour as gene expression,” he said. Until now, however, this complex dance of cellular material has remained largely unstudied. As a result, scientists have been able to identify the elements that make up a cell, but not how the cell interior behaves as a whole.

“From studies in biology and embryology, we know about certain molecules and cellular phenomena, and we have woven this information into a reductionist narrative of how things work, but now this narrative is changing,” said Professor Perry. The narrative was written largely by biologists, who brought with them the questions and tools of biology. What was missing was physics. Physics asks about the forces driving a cell’s behaviour, and provides a top-down approach to finding the answer.

“We can now look at the cell as a whole, not just the nuts and bolts that make it.”

Mouse embryos were chosen for the study because of their relatively large size (they measure 100 microns, or 100-millionths of a metre, in diameter, compared to a regular cell which is only 10 microns [10-millionths of a metre] in diameter). This meant that inside each embryo, there was space for a tracking device.

The researchers made their measurements by examining video recordings taken through a microscope as the embryo developed. “Sometimes the devices were pitched and twisted by forces that were even greater than those inside muscle cells,” said Professor Perry. “At other times, the devices moved very little, showing the cell interior had become calm. There was nothing random about these processes – from the moment you have a one-cell embryo, everything is done in a predictable way. The physics is programmed.”

The results add to an emerging picture of biology that suggests material inside a living cell is not static, but instead changes its properties in a pre-ordained way as the cell performs its function or responds to the environment. The work may one day have implications for our understanding of how cells age or stop working as they should, which is what happens in disease.

The study is published this week in Nature Materials and involved a trans-disciplinary partnership between biologists, materials scientists and physicists based in the UK, Spain and the USA.

Here’s a link to and a citation for the paper,

Tracking intracellular forces and mechanical property changes in mouse one-cell embryo development by Marta Duch, Núria Torras, Maki Asami, Toru Suzuki, María Isabel Arjona, Rodrigo Gómez-Martínez, Matthew D. VerMilyea, Robert Castilla, José Antonio Plaza & Anthony C. F. Perry. Nature Materials (2020) DOI: https://doi.org/10.1038/s41563-020-0685-9 Published 25 May 2020

This paper is behind a paywall.

They all fall down or not? Quantum dot-doped nanoparticles for preserving national monuments and buildings

The most recent post here but not the most recent research about preserving stone monuments and buildings is a December 23, 2019 piece titled: Good for your bones and good for art conservation: calcium. Spanish researchers (who seem particularly active in this research niche) are investigating a more refined approach to preserving stone monuments with calcium according to a May 8, 2020 news item on Nanowerk,

The fluorescence emitted by tiny zinc oxide quantum dots can be used to determine the penetration depth of certain substances used in the restoration of historical buildings. Researchers from Pablo de Olavide University (Spain) have tested this with samples collected from historical quarries in Cadiz, where the stone was used to build the city hall and cathedral of Seville.

One of the main problems in the preservation of historic buildings is the loss of cohesion of their building materials. Restorers use consolidating substances to make them more resistant, such as lime (calcium hydroxide), which has long been used because of its great durability and high compatibility with the carbonate stone substrate.

Now, researchers at Pablo de Olavide University, in Seville, have developed and patented calcium hydroxide nanoparticles doped with quantum dots that are more effective as consolidant and make it possible to distinguish the restored from the original material, as it is recommended for the conservation and restoration of historical heritage.

An April 28, 2020 Pablo de Olavide University press release (also on Alpha Gallileo but published May 5, 2020), which originated the news item, provides more details about the nature of the materials,

“The tiny quantum dots, which are smaller than 10 nanometres, are made of zinc oxide and are semiconductors, which gives them very interesting properties (different from those of larger particles due to quantum mechanics), such as fluorescence, which is the one we use,” explains Javier Becerra, one of the authors.

“Thanks to the fluorescence of these quantum dots, we can evaluate the suitability of the treatment for a monument,” he adds. “We only need to illuminate with ultraviolet light a cross-section of the treated material to determine how far the consolidating matter has penetrated.”

In addition, the product, which the authors have named Nanorepair UV, acts as a consolidant due to the presence of the lime nanoparticles. Consolidation is a procedure that increases the degree of cohesion of a material, reinforcing and hardening the parts that have suffered some deterioration, which is frequent in historical buildings.

The researchers have successfully applied their technique to samples collected in the historic quarries of El Puerto de Santa María and Espera (Cadiz), from where the stone used to build such iconic monuments as Seville Cathedral, a World Heritage Site since 1987, or the town’s city hall, was extracted.

“In the laboratory, we thus obtain an approximation of how the treatment will behave when it is actually applied to the monuments,” says Becerra, who together with the rest of the team, is currently also testing mortars from the Italica and Medina Azahara archaeological sites.

Oddly, this work is not all that recently published. In any event, here’s a link to and a citation for the paper,

Nanolimes doped with quantum dots for stone consolidation assessment by Javier Becerra, Pilar Ortiz, José María Martín, Ana Paula Zaderenko. Construction and Building Materials Volume 199, 28 February 2019, Pages 581-593 DOI: https://doi.org/10.1016/j.conbuildmat.2018.12.077 Available online 19 December 2018

This paper is behind a paywall.

Entangling 15 trillion atoms is a hot and messy business

A May 15, 2020 news item on Nanowerk provides context for an announcement of a research breakthrough on quantum entanglement,

Quantum entanglement is a process by which microscopic objects like electrons or atoms lose their individuality to become better coordinated with each other. Entanglement is at the heart of quantum technologies that promise large advances in computing, communications and sensing, for example detecting gravitational waves.

Entangled states are famously fragile: in most cases even a tiny disturbance will undo the entanglement. For this reason, current quantum technologies take great pains to isolate the microscopic systems they work with, and typically operate at temperatures close to absolute zero.

The ICFO [Institute of Photonic Sciences; Spain] team, in contrast, heated a collection of atoms to 450 Kelvin, millions of times hotter than most atoms used for quantum technology. Moreover, the individual atoms were anything but isolated; they collided with each other every few microseconds, and each collision set their electrons spinning in random directions.

Caption: Artistic illustration of a cloud of atoms with pairs of particles entangled between each other, represented by the yellow-blue lines. Image credit: © ICFO

A May 15, 2020 (?) ICFO press release (also on EurekAlert), which originated the news item, delves further into details abut the research,

The researchers used a laser to monitor the magnetization of this hot, chaotic gas. The magnetization is caused by the spinning electrons in the atoms, and provides a way to study the effect of the collisions and to detect entanglement. What the researchers observed was an enormous number of entangled atoms – about 100 times more than ever before observed. They also saw that the entanglement is non-local – it involves atoms that are not close to each other. Between any two entangled atoms there are thousands of other atoms, many of which are entangled with still other atoms, in a giant, hot and messy entangled state.

What they also saw, as Jia Kong, first author of the study, recalls, “is that if we stop the measurement, the entanglement remains for about 1 millisecond, which means that 1000 times per second a new batch of 15 trillion atoms is being entangled. And you must think that 1 ms is a very long time for the atoms, long enough for about fifty random collisions to occur. This clearly shows that the entanglement is not destroyed by these random events. This is maybe the most surprising result of the work”.

The observation of this hot and messy entangled state paves the way for ultra-sensitive magnetic field detection. For example, in magnetoencephalography (magnetic brain imaging), a new generation of sensors uses these same hot, high-density atomic gases to detect the magnetic fields produced by brain activity. The new results show that entanglement can improve the sensitivity of this technique, which has applications in fundamental brain science and neurosurgery.

As ICREA [Catalan Institution for Research and Advanced Studies] Prof. at ICFO Morgan Mitchell states, “this result is surprising, a real departure from what everyone expects of entanglement.” He adds “we hope that this kind of giant entangled state will lead to better sensor performance in applications ranging from brain imaging to self-driving cars to searches for dark matter

A Spin Singlet and QND

A spin singlet is one form of entanglement where the multiple particles’ spins–their intrinsic angular momentum–add up to 0, meaning the system has zero total angular momentum. In this study, the researchers applied quantum non-demolition (QND) measurement to extract the information of the spin of trillions of atoms. The technique passes laser photons with a specific energy through the gas of atoms. These photons with this precise energy do not excite the atoms but they themselves are affected by the encounter. The atoms’ spins act as magnets to rotate the polarization of the light. By measuring how much the photons’ polarization has changed after passing through the cloud, the researchers are able to determine the total spin of the gas of atoms.

The SERF regime

Current magnetometers operate in a regime that is called SERF, far away from the near absolute zero temperatures that researchers typically employ to study entangled atoms. In this regime, any atom experiences many random collisions with other neighbouring atoms, making collisions the most important effect on the state of the atom. In addition, because they are in a hot medium rather than an ultracold one, the collisions rapidly randomize the spin of the electrons in any given atom. The experiment shows, surprisingly, that this kind of disturbance does not break the entangled states, it merely passes the entanglement from one atom to another.

Here’s a link to and a citation for the paper,

Measurement-induced, spatially-extended entanglement in a hot, strongly-interacting atomic system by Jia Kong, Ricardo Jiménez-Martínez, Charikleia Troullinou, Vito Giovanni Lucivero, Géza Tóth & Morgan W. Mitchell. Nature Communications volume 11, Article number: 2415 (2020) DOI: https://doi.org/10.1038/s41467-020-15899-1 Published1 5 May 2020

This paper is open access.

Get better protection from a sunscreen with a ‘flamenco dancing’ molecule?

Caption: illustrative image for the University of Warwick research on ‘Flamenco dancing’ molecule could lead to better-protecting sunscreen created by Dr. Michael Horbury. Credit:: created by Dr Michael Horbury

There are high hopes (more about why later) for a plant-based ‘flamenco dancing molecule’ and its inclusion in sunscreens as described in an October 18, 2019 University of Warwick press release (also on EurekAlert),

A molecule that protects plants from overexposure to harmful sunlight thanks to its flamenco-style twist could form the basis for a new longer-lasting sunscreen, chemists at the University of Warwick have found, in collaboration with colleagues in France and Spain. Research on the green molecule by the scientists has revealed that it absorbs ultraviolet light and then disperses it in a ‘flamenco-style’ dance, making it ideal for use as a UV filter in sunscreens.

The team of scientists report today, Friday 18th October 2019, in the journal Nature Communications that, as well as being plant-inspired, this molecule is also among a small number of suitable substances that are effective in absorbing light in the Ultraviolet A (UVA) region of wavelengths. It opens up the possibility of developing a naturally-derived and eco-friendly sunscreen that protects against the full range of harmful wavelengths of light from the sun.

The UV filters in a sunscreen are the ingredients that predominantly provide the protection from the sun’s rays. In addition to UV filters, sunscreens will typically also include:

Emollients, used for moisturising and lubricating the skin
Thickening agents
Emulsifiers to bind all the ingredients
Other components that improve aesthetics, water resistance, etc.

The researchers tested a molecule called diethyl sinapate, a close mimic to a molecule that is commonly found in the leaves of plants, which is responsible for protecting them from overexposure to UV light while they absorb visible light for photosynthesis.

They first exposed the molecule to a number of different solvents to determine whether that had any impact on its (principally) light absorbing behaviour. They then deposited a sample of the molecule on an industry standard human skin mimic (VITRO-CORNEUM®) where it was irradiated with different wavelengths of UV light. They used the state-of-the-art laser facilities within the Warwick Centre for Ultrafast Spectroscopy to take images of the molecule at extremely high speeds, to observe what happens to the light’s energy when it’s absorbed in the molecule in the very early stages (millionths of millionths of a second). Other techniques were also used to establish longer term (many hours) properties of diethyl sinapate, such as endocrine disruption activity and antioxidant potential.

Professor Vasilios Stavros from the University of Warwick, Department of Chemistry, who was part of the research team, explains: “A really good sunscreen absorbs light and converts it to harmless heat. A bad sunscreen is one that absorbs light and then, for example, breaks down potentially inducing other chemistry that you don’t want. Diethyl sinapate generates lots of heat, and that’s really crucial.”

When irradiated the molecule absorbs light and goes into an excited state but that energy then has to be disposed of somehow. The team of researchers observed that it does a kind of molecular ‘dance’ a mere 10 picoseconds (ten millionths of a millionth of a second) long: a twist in a similar fashion to the filigranas and floreos hand movements of flamenco dancers. That causes it to come back to its original ground state and convert that energy into vibrational energy, or heat.

It is this ‘flamenco dance’ that gives the molecule its long-lasting qualities. When the scientists bombarded the molecule with UVA light they found that it degraded only 3% over two hours, compared to the industry requirement of 30%.

Dr Michael Horbury, who was a Postgraduate Research Fellow at The University Warwick when he undertook this research (and now at the University of Leeds) adds: “We have shown that by studying the molecular dance on such a short time-scale, the information that you gain can have tremendous repercussions on how you design future sunscreens.
Emily Holt, a PhD student in the Department of Chemistry at the University of Warwick who was part of the research team, said: “The next step would be to test it on human skin, then to mix it with other ingredients that you find in a sunscreen to see how those affect its characteristics.”

Professor Florent Allais and Dr Louis Mouterde, URD Agro-Biotechnologies Industrielles at AgroParisTech (Pomacle, France) commented: “What we have developed together is a molecule based upon a UV photoprotective molecule found in the surface of leaves on a plant and refunctionalised it using greener synthetic procedures. Indeed, this molecule has excellent long-term properties while exhibiting low endocrine disruption and valuable antioxidant properties.”

Professor Laurent Blasco, Global Technical Manager (Skin Essentials) at Lubrizol and Honorary Professor at the University of Warwick commented: “In sunscreen formulations at the moment there is a lack of broad-spectrum protection from a single UV filter. Our collaboration has gone some way towards developing a next generation broad-spectrum UV filter inspired by nature. Our collaboration has also highlighted the importance of academia and industry working together towards a common goal.”

Professor Vasilios Stavros added, “Amidst escalating concerns about their impact on human toxicity (e.g. endocrine disruption) and ecotoxicity (e.g. coral bleaching), developing new UV filters is essential. We have demonstrated that a highly attractive avenue is ‘nature-inspired’ UV filters, which provide a front-line defence against skin cancer and premature skin aging.”

Here’s a link to and a citation for the paper,

Towards symmetry driven and nature inspired UV filter design by Michael D. Horbury, Emily L. Holt, Louis M. M. Mouterde, Patrick Balaguer, Juan Cebrián, Laurent Blasco, Florent Allais & Vasilios G. Stavros. Nature Communications volume 10, Article number: 4748 (2019) DOI: https://doi.org/10.1038/s41467-019-12719-z

This paper is open access.

Why the high hopes?

Briefly (the long story stretches over 10 years), the most recommended sunscreens today (2020) are ‘mineral-based’. This is painfully amusing because civil society groups (activists) such as Friends of the Earth (in particular the Australia chapter under Georgia Miller’s leadership) and Canada’s own ETC Group had campaigned against these same sunscreen when they were billed as being based on metal oxide nanoparticles such zinc oxide and/or titanium oxide. The ETC Group under Pat Roy Mooney’s leadership didn’t press the campaign after an initial push. As for Australia and Friend of the Earth, their anti-metallic oxide nanoparticle sunscreen campaign didn’t work out well as I noted in a February 9, 2012 posting and with a follow-up in an October 31, 2012 posting.

The only civil society group to give approval (very reluctantly) was the Environmental Working Group (EWG) as I noted in a July 9, 2009 posting. They had concerns about the fact that these ingredients are metallic but after a thorough of then available research, EWG gave the sunscreens a passing grade and noted, in their report, that they had more concerns about the use of oxybenzone in sunscreens. That latter concern has since been flagged by others (e.g., the state of Hawai’i) as noted in my July 6, 2018 posting.

So, rebranding metallic oxides as minerals has allowed the various civil society groups to support the very same sunscreens many of them were advocating against.

In the meantime, scientists continue work on developing plant-based sunscreens as an improvement to the ‘mineral-based’ sunscreens used now.