Tag Archives: McMaster University

Dance experience visible in brain activity of audience members watching dance

Caption: Iron Skulls Co dancers Adrian Vega (left) and Diego Garrido performed the dance duet Un último recuerdo for the spectators participating in the study. Photo Credit: Juanmi Ponce

An October 2, 2024 University of Helsinki press release (also on EurekAlert but published October 15, 2024) describes research exploring the differences in brain activity between audience members with extensive dance or music experience and audiences with little of experience of either,

University of Helsinki researchers measured the brain activity of people watching a live dance performance in a real-world setting. They invited spectators with extensive experience of either dance or music as well as novices with no particular background in either of these areas.

The spectators’ brain activity was measured using EEG while they watched the live dance duet Un último recuerdo, a piece created by the Spanish Iron Skulls Co that combines contemporary dance and breakdance.

Experienced dancers respond more strongly than novices

The results showed that dance experience is detectable in spectators’ brain activity during a dance performance. The experienced dancers watching the performance displayed stronger synchronisation than the novices at the low theta frequency.

Experience of dance affects brain functions associated with the visualisation of movement in the mind, the simultaneous integration of several sensory stimuli (listening to music and watching dance) and social interaction.

When musicians watched the live dance performance, they had stronger synchrony in the delta band, which is even lower than theta. This may be associated with the musicians’ trained ability to observe rhythmic bodily movements.

Watching dance in a real-world environment is unique for our brain

The effect of watching a dance performance on brain activity has previously been studied by having subjects watch a video recording on their own in a brain research laboratory.

The present study was conducted in a real-world performance environment and shows that watching a live dance performance in a full venue activates the brain more extensively than the above setting.

“As our interaction increasingly moves to online platforms and the virtual world, it’s important to know that real-world interaction is unique – for our body and brain,” says Hanna Poikonen, the lead author of the study.

The results also emphasise the effect of a background in creative movement on the spectator experience.

“If we have practised our bodily skills, we may better understand the body language of others, which makes social interaction smoother,” Poikonen notes.

Here’s a link to and a citation for the paper,

Cortical oscillations are modified by expertise in dance and music: Evidence from live dance audience by Hanna Poikonen, Mari Tervaniemi, Laurel Trainor. European Journal of Neuroscience (EJN) Volume 60, Issue 8 October 2024 Pages 6000-6014 DOI: https://doi.org/10.1111/ejn.16525 First published online: 15 September 2024

This paper is open access.

Way back in time (see my March 6, 2012 posting), I featured some research into how experienced ballet watchers (not dancers or musicians) experienced a ballet performance.

Not quite so far back in time, I mentioned Laurel Trainor (third author listed on the paper) in a November 29, 2019 posting that featured (amongst other items) the Large Interactive Virtual Environment Laboratory (LIVELab) located in McMaster University’s (Ontario, Canada) Institute for Music & the Mind (MIMM).

Painless, wearable patch for continuous smartphone monitoring of critical health data from Canadian researchers

A June 18, 2024 McMaster University news release also on EurekAlert and on the University of Waterloo news website) by Wade Hemsworth describes the ‘Wearable Aptalyzer’, Note: A link has been removed,

Researchers at two Ontario universities have developed a pain-free, wearable sensor that can continuously monitor levels of blood sugar, lactates and other critical health indicators for weeks at a time, sending results to a smartphone or other device.

The Wearable Aptalyzer, created by a team featuring researchers from McMaster University and the University of Waterloo, uses an array of tiny hydrogel needles that penetrate just deeply enough to reach the interstitial fluid beneath the skin, but not far enough to reach the blood vessels or nerves.

The patch gathers and sends information about markers in the fluid to an electronic device such as a smart phone, creating an ongoing record of patterns in the rise and fall of critical biomarkers.

Once developed for clinical use, it will allow health professionals to access current medical information that today is available only retrospectively after blood tests and lab work.

The new technology could make monitoring the markers of specific diseases and conditions as simple as tracking pulse, blood pressure and other vital signs. The researchers describe the work in a new paper published today [version of record published May 16, 2024] in the journal Advanced Materials.

“This technology can provide real-time information about both chronic and acute health conditions, allowing caregivers to act more quickly and with greater certainty when they see trouble,” says one of the paper’s two corresponding authors, McMaster’s Leyla Soleymani,  professor of Engineering Physics who holds the Canada Research Chair in Miniaturized Biomedical Devices.

“The Wearable Aptalyzer is a general platform, meaning it can measure any biomarkers of interest, ranging from diabetes to cardiac biomarkers,” says corresponding author Mahla Poudineh, an assistant professor and director of the IDEATION Lab in the Department of Electrical and Computer Engineering at Waterloo. “Continuous health monitoring doesn’t just help catch diseases early and track how treatments are working. It also helps us understand how diseases happen, filling in important gaps in our knowledge that need attention.”

A user would apply and remove the patch much like a small bandage held in place with barely visible, soft hooks. The convenience is likely to appeal to diabetics and others who test themselves by drawing samples of blood or by using solid monitoring patches with metal needles that penetrate deeper and rely on less specific electrodes.

The greatest promise of the technology, though, may lie in its ability to produce weeks’ worth of meaningful results at a time, and to transmit data to electronic devices experts can read without sophisticated equipment.

Among the other potential applications, the Wearable Aptalyzer can make it possible to read and send data that signals cardiac events in real time, making it a potentially valuable tool for monitoring patients in ambulances and emergency rooms, and during treatment. The same technology can readily be adapted to monitor the progress and treatment of many chronic illnesses, including cancers, the researchers say.

The technology holds promise for improving care use in remote care settings, such as northern Indigenous communities set far from hospitals, or on space flights. Data from the Wearable Aptalyzer can signal trouble before symptoms become apparent, making it more likely patients can receive timely care.

The next steps in developing the technology for broad use include human trials and regulatory approvals. The researchers are seeking partners to help commercialize the technology.

The paper’s lead authors are Fatemeh Bakhshandeh of McMaster and Hanjia Zheng of Waterloo. Together with Soleymani and Poudineh, their co-authors are Waterloo’s Sadegh Sadeghzadeh, Irfani Ausri, Fatemeh Keyvani, Fasih Rahman, Joe Quadrilatero, and Juewen Liu, and McMaster’s Nicole Barra, Payel Sen, and Jonathan Schertzer.

Caption: The monitoring patch as compared to a 25-cent coin for scale. Credit: University of Waterloo

Here’s a link to and a citation for the paper,

Wearable Aptalyzer Integrates Microneedle and Electrochemical Sensing for In Vivo Monitoring of Glucose and Lactate in Live Animals by Fatemeh Bakhshandeh, Hanjia Zheng, Nicole G. Barra, Sadegh Sadeghzadeh, Irfani Ausri, Payel Sen, Fatemeh Keyvani, Fasih Rahman, Joe Quadrilatero, Juewen Liu, Jonathan D. Schertzer, Leyla Soleymani, Mahla Poudineh. Advanced Materials 2313743 DOI: https://doi.org/10.1002/adma.202313743 First online version of record published: 16 May 2024

This paper is open access.

Collaborative research agreement (CRA) with McMaster University (Canada) for development of catheter coating

I don’t always do as good a job at covering the commercialization of emerging technologies as I’d like, so, this December 13, 2023 news item on Yahoo News was a welcome discovery,

Oakville, Ontario–(Newsfile Corp. – December 13, 2023) – FendX Technologies Inc. (CSE: FNDX) (OTCQB: FDXTF) (FSE: E8D) (the “Company” or “FendX“), a nanotechnology company developing surface protection coatings is pleased to announce it has entered into a Collaborative Research Agreement (“CRA“) dated December 12, 2023 with McMaster University (“McMaster“) which details the research and development plan to create a protective catheter coating using our nanotechnology licensed pursuant to the license agreement dated February 5, 2021, as amended, between the Company and McMaster.

Dr. Carolyn Myers, President and CEO of FendX, stated, “We are excited about the prospect of developing a coating for catheters using our nanotechnology which we believe will reduce catheter blockage caused by either blood clots or bacterial biofilms. Early work conducted at McMaster has demonstrated significant reduction in the adherence of both bacteria and blood which could potentially translate to reduced bacterial biofilm or blood clot formation. [emphasis mine] Our aim is to further this research to tackle the medical need to reduce catheter blockage rates, which can be costly and interfere with patient therapy. We anticipate the development of this coating formulation will also strengthen our overall intellectual property portfolio.”

The CRA outlines more fully the research and development work to be conducted by McMaster on behalf of FendX as well as a payment schedule for the maximum research funding requirements. The term of the CRA is for 24 months commencing on the effective date of December 1, 2023, unless terminated in accordance with the provisions of the CRA. In the first and second year, maximum research funding to McMaster will be $150,547 each year.

About FendX Technologies Inc.

FendX is a Canada-based nanotechnology company focused on developing products to make people’s lives safer by reducing the spread of pathogens. The Company is developing both film and spray products to protect surfaces from contamination. The lead product under development, REPELWRAP™ film, is a protective surface coating film that, due to its repelling properties, prevents the adhesion of pathogens and reduces their transmission on surfaces prone to contamination. The spray nanotechnology is a bifunctional spray coating being developed to reduce contamination on surfaces by repelling and killing pathogens. The Company is conducting research and development activities using its nanotechnology in collaboration with industry-leading partners, including McMaster University. The Company has an exclusive worldwide license to its technology and IP portfolio from McMaster, which encompass both film and spray coating nanotechnology formulations.

For more information, please visit https://fendxtech.com/ and the Company’s profile on SEDAR+ at www.sedarplus.ca.

Neither the Canadian Securities Exchange nor the Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-Looking Statements

This news release contains certain forward-looking statements within the meaning of Canadian securities legislation, including with respect to: the plans of the Company; statements regarding the catheter coating development and anticipated benefits; the Company’s belief that the catheter coating could reduce catheter occlusions caused by either blood clots or bacterial biofilms; statements regarding strengthening the Company’s overall intellectual property portfolio; the Company’s belief that REPELWRAP™ will have applications in healthcare settings and other industries; and products under development and any pathogen reduction benefits related thereto. Although the Company believes that such statements are reasonable, it can give no assurance that such expectations will prove to be correct. Forward-looking statements are statements that are not historical facts; they are generally, but not always, identified by the words “expects,” “plans,” “anticipates,” “believes,” “intends,” “estimates,” “projects,” “aims,” “potential,” “goal,” “objective,” “prospective,” and similar expressions, or that events or conditions “will,” “would,” “may,” “can,” “could” or “should” occur, or are those statements, which, by their nature, refer to future events. The Company cautions that forward-looking statements are based on the beliefs, estimates and opinions of the Company’s management on the date the statements are made and involve several risks and uncertainties. Consequently, there can be no assurances that such statements will prove to be accurate and that actual results and future events could differ materially from those anticipated in such statements.

Important factors that could cause future results to differ materially from those anticipated in these forward-looking statements include: product candidates only being in formulation/reformulation stages; limited operating history; research and development activities; dependence on collaborative partners, licensors and others; effect of general economic and political conditions; and other risk factors set forth in the Company’s public filings which are available on SEDAR+ at www.sedarplus.ca. Accordingly, the reader is urged to refer to the Company’s such filings for a more complete discussion of such risk factors and their potential effects. Except to the extent required by applicable securities laws and the policies of the Canadian Securities Exchange, the Company undertakes no obligation to update these forward-looking statements if management’s beliefs, estimates or opinions, or other factors should change.

FendX offers next to no information about their technology or the proposed work with McMaster as seen in this excerpt from the Our Technology webpage on the FendX website,

Our patent-pending licensed nanotechnology works by combining a hierarchical wrinkled molecular structure with chemical functionalization to create nano-surfaces with repelling properties that prevent adhesion of bacteria, viruses and liquids.

Inspired by the water-resistant surface of the lotus leaf

Our nanotechnology causes both high surface tension (e.g., water) and low surface tension (e.g., oil) liquids to form droplets when they come in contact with the nano-surface.

The repelling properties of our nano-surfaces prevents adhesion of bacteria and viruses.

We believe our technology will have numerous applications and opportunities in healthcare and other industries.

That’s it. No technical details and not a single research study is cited.

While McMaster University doesn’t seem to have issued any news releases about their joint research effort with FendX, there are two research papers that I’m reasonably confident are relevant. From the Didar Lab Publications webpage, here are links and citation for both papers,

An omniphobic lubricant-infused coating produced by chemical vapor deposition of hydrophobic organosilanes attenuates clotting on catheter surfaces by Maryam Badv, Iqbal H. Jaffer, Jeffrey I. Weitz & Tohid F. Didar. Scientific Reports volume 7, Article number: 11639 (2017) DOI: https://doi.org/10.1038/s41598-017-12149-1 Published: 14 September 2017

This paper is open access.

Highly Stable Hierarchically Structured All-Polymeric Lubricant-Infused Films Prevent Thrombosis and Repel Multidrug-Resistant Pathogens by Elisabet Afonso, Fereshteh Bayat, Liane Ladouceur, Shadman Khan, Aránzazu Martínez-Gómez, Jeffrey I. Weitz, Zeinab Hosseinidoust, Pilar Tiemblo, Nuria García, and Tohid F. Didar. CS Appl. Mater. Interfaces 2022, 14, 48, 53535–53545 DOI: https://doi.org/10.1021/acsami.2c17309 Publication Date: November 22, 2022 Copyright © 2022 American Chemical Society

This paper is behind a paywall.

Canadian Forum on Innovation and Societal Impact launches at McMaster University on Oct. 12th and 13th 2022

The Canadian Science Policy Centre’s September 22, 2022 announcement (received via email) includes this nugget of information,

The Canadian Forum on Innovation and Societal Impact [CFSI] will launch in the Fall 2022 with a first series of catalyst roundtables, deliberative dialogues and concertation workshops at McMaster University on October 12th and 13th,  2022. A joint-venture of the Canadian Science Policy Centre and The/La Collaborative, CFISI will convene social research and innovation stakeholders across sectors with the purpose of exploring alignment on policies and practices that leverage impact-first training and knowledge mobilisation in the Social Sciences, Humanities and Arts (SSHA) to foster innovation and build capacity in the social and municipal sectors. For more information, please click here.

I went to the CFSI webpage on the McMaster University website and found this,

The objective of the inaugural meeting is to understand how universities can better utilize and mobilize social and human knowledge into their communities, in particular into social sector organizations (non-profit, charities, funders) and municipal governments. What are the knowledge gaps? What are the needs and priorities in social sector organizations and the social innovation ecosystem? Which approaches to cross-sectoral and interdisciplinary collaborations can help address the biggest social and policy challenges?

The event is by invitation only [emphasis mine], and will proceed under the Chatham House rules. Sessions will leverage strategic visioning and deliberative dialogue to create stakeholder alignment and deliver a first series of action plans.

Participants will bring individual and organisational perspectives on a range issues including:

The nature and structure of innovation in the social sector.

Campus-community relationship and the challenges of knowledge mobilisation in social innovation ecosystem

The role of municipal governments in fostering innovation in the social space

Needs around policy innovation and talent in the social and municipal sector.

Contribution of Indigenous knowledge to social sector, local policy making

Who are the Participants?

Social sector organisation leaders

Social Innovation stakeholders

Research and higher education policy stakeholders

Decision- and policy-makers from municipal governments

Social and human sciences researchers

Concertation and Action Plan

The event is intended as a concertation and consultation. Sense-making workshops and consultative roundtables will aim at building consensus around key concepts and best-practices. Catalysts panels and reporting sessions will aim to establish a shared vision for an action plan around cross-sectoral strategies for innovation in the social impact ecosystem.

The genuinely cross-sectoral setting will provide an opportunity to learn from a variety of perspectives in an effort to reduce barriers to knowledge-driven collaboration and partnerships and increase the social capital of research institutions to streamline impact.

This is where it got interesting,

SUBMIT A LETTER OF INTENT TO REQUEST PARTICIPATION

The event is by invitation only and will proceed under the Chatham House rules. Those with a demonstrated interest in the theme of the Forum can submit a letter of intent to request participation in the meeting. The number of places is limited.

Please fill out the participation request FORM and return it to:

forum22@mcmaster.ca

The deadline for submitting the form is September 15th [2022; emphases mine].
Applicants will be notified shortly thereafter.

It’s a bit late but perhaps there’s a little space left for more participants?

I’m not able to confirm whether this event is in person (in Hamilton, Ontario), online, or hybrid (in person and online).

Inhaled vaccine delivers broad protection against SARS-CoV-2

The results described in the news release are from a preclinical study, meaning they tested the vaccine on animals. The results were promising enough that there is a phase 1 clinical trial taking place now. On to the news.

A February 9, 2022 news item on ScienceDaily features some exciting research news,

Scientists at McMaster University who have developed an inhaled form of COVID vaccine have confirmed it can provide broad, long-lasting protection against the original strain of SARS-CoV-2 and variants of concern.

The research, recently published in the journal Cell, reveals the immune mechanisms and significant benefits of vaccines being delivered directly into the respiratory tract, rather than by traditional injection.

A February 9, 2022 McMaster University news release (also on EurekAlert) by Michelle Donovan, which originated the news item, provides more detail about the work,

Because inhaled vaccines target the lungs and upper airways where respiratory viruses first enter the body, they are far more effective at inducing a protective immune response, the researchers report.

The reported preclinical study, which was conducted on animal models, has provided the critical proof of concept to enable a Phase 1 clinical trial that is currently under way to evaluate inhaled aerosol vaccines in healthy adults who had already received two doses of a COVID mRNA vaccine.

The tested COVID vaccine strategy was built upon a robust tuberculosis vaccine research program established by Zhou Xing, a co-lead author of the new study and a professor at the McMaster Immunology Research Centre and Department of Medicine. 

“What we’ve discovered from many years’ research is that the vaccine delivered into the lung induces all-around protective respiratory mucosal immunity, a property that the injected vaccine is lacking,” Xing says.

Currently authorized COVID vaccines are all injected.   

“We wanted, first and foremost, to design a vaccine that would work well against any variant,” explains the study’s co-lead author Matthew Miller, an associate professor at McMaster’s Michael G. DeGroote Institute for Infectious Disease Research.

The McMaster COVID vaccine represents one of only a handful developed in Canada. The urgent work is a critical mission of Canada’s Global Nexus for Pandemics and Biological Threats, which is based at McMaster.

Researchers compared two types of adenovirus platforms for the vaccine. The viruses serve as vectors that can deliver vaccine directly to the lungs without causing illness themselves.

“We can remain ahead of the virus with our vaccine strategy,” says Miller. “Current vaccines are limited because they will need to be updated and will always be chasing the virus.”

Both types of the new McMaster vaccine are effective against highly transmissible variants because they are designed to target three parts of the virus, including two that are highly conserved among coronaviruses and do not mutate as quickly as spike. All COVID vaccines currently approved in Canada target only the spike protein, which has shown a remarkable ability to mutate.

“This vaccine might also provide pre-emptive protection against a future pandemic, and that’s really important because as we’ve seen during this pandemic – and as we saw in 2009 with the swine flu – even when we are able to rapidly make a vaccine for a pandemic virus, it’s already way too late. Millions of people died, even though we were able to make a vaccine in record time,” says Miller.

“We have revealed in our report that besides neutralizing antibodies and T cell immunity, the vaccine delivered into the lungs stimulates a unique form of immunity known as trained innate immunity, which is able to provide very broad protection against many lung pathogens besides SARS-CoV-2,” Xing adds. 

In additional to being needle and pain-free, an inhaled vaccine is so efficient at targeting the lungs and upper airways that it can achieve maximum protection with a small fraction of the dose of current vaccines – possibly as little as 1 per cent – meaning a single batch of vaccine could go 100 times further, the researchers say.

“This pandemic has shown us that vaccine supply can be a huge challenge.  Demonstrating that this alternative delivery method can significantly extend vaccine supply could be a game changer, particularly in a pandemic setting,” says Brian Lichty, an associate professor in the Department of Medicine who co-led the preclinical study along with Miller, Xing and the senior trainees Sam Afkhami and Michael D’Agostino, who are the joint first authors of the study.

Here’s a link to and a citation for the paper,

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2 by Sam Afkhami, Michael R. D’Agostino, Ali Zhang, Hannah D. Stacey, Art Marzok, Alisha Kang, Ramandeep Singh, Jegarubee Bavananthasivam, Gluke Ye, Xiangqian Luo, Fuan Wang, Jann C. Ang, Anna Zganiacz, Uma Sankar, Natallia Kazhdan, Joshua F.E. Koenig, Allyssa Phelps, Steven F. Gameiro, Shangguo Tang, Manel Jordana, Yonghong Wan, Karen L. Mossman, Mangalakumari Jeyanathan, Amy Gillgrass, Maria Fe C. Medina, Fiona Smaill, Brian D. Lichty, Matthew S. Miller, Zhou Xing. Cell, 2022; DOI: 10.1016/j.cell.2022.02.005

This is a ‘pre-proof’ journal paper. It is open access. However, from the PDF of the article, there is this statement from the journal publishers,

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 The Author(s). Published by Elsevier Inc.

In short, reader beware!

A better quality of cultivated meat from McMaster University?

This could be a bit stomach-churning for some folks.

Researchers at Canada’s McMaster University have developed and are commercializing a technique for cultivated meat (the first experiment involved mouse meat). (You could call it vat-grown meat.) A January 19, 2021 news item on phys.org makes the announcement (Note: Links have been removed),

McMaster researchers have developed a new form of cultivated meat using a method that promises more natural flavor and texture than other alternatives to traditional meat from animals.

Researchers Ravi Selvaganapathy and Alireza Shahin-Shamsabadi, both of the university’s School of Biomedical Engineering, have devised a way to make meat by stacking thin sheets of cultivated muscle and fat cells grown together in a lab setting. The technique is adapted from a method used to grow tissue for human transplants.

A January 19, 2021 McMaster University news release (also on EurekAlert) by Wade Hemsworth, which originated the news item, offers more details,

The sheets of living cells, each about the thickness of a sheet of printer paper, are first grown in culture and then concentrated on growth plates before being peeled off and stacked or folded together. The sheets naturally bond to one another before the cells die.

The layers can be stacked into a solid piece of any thickness, Selvaganapathy says, and “tuned” to replicate the fat content and marbling of any cut of meat – an advantage over other alternatives.

“We are creating slabs of meat,” he says. “Consumers will be able to buy meat with whatever percentage of fat they like – just like they do with milk.”

As they describe in the journal Cells Tissues Organs, the researchers proved the concept by making meat from available lines of mouse cells. Though they did not eat the mouse meat described in the research paper, they later made and cooked a sample of meat they created from rabbit cells.

“It felt and tasted just like meat,” says Selvaganapathy.

There is no reason to think the same technology would not work for growing beef, pork or chicken, and the model would lend itself well to large-scale production, Selvaganapathy says.

The researchers were inspired by the meat-supply crisis in which worldwide demand is growing while current meat consumption is straining land and water resources and generating troubling levels of greenhouse gases.

“Meat production right now is not sustainable,” Selvaganapathy says. “There has to be an alternative way of creating meat.”

Producing viable meat without raising and harvesting animals would be far more sustainable, more sanitary and far less wasteful, the researchers point out. While other forms of cultured meat have previously been developed, the McMaster researchers believe theirs has the best potential for creating products consumers will accept, enjoy and afford.

The researchers have formed a start-up company to begin commercializing the technology.

The researchers have included a picture of the ‘meat’,

Caption: A sample of meat cultivated by researchers at Canada’s McMaster University, using cells from mice. Credit: McMaster University

Here’s a link to and a citation for the paper,

Engineering Murine Adipocytes and Skeletal Muscle Cells in Meat-like Constructs Using Self-Assembled Layer-by-Layer Biofabrication: A Platform for Development of Cultivated Meat by Alireza Shahin-Shamsabadi and P. R. (Ravi) Selvaganapathy. Cells Tissues Organs (2021). DOI: 10.1159/000511764

This paper is behind a paywall.

Replacing nanotechnology-enabled oil spill solutions with dog fur?

Coincidentally or not, this research from Australia was announced a little more than a month after reports of a major oil spill in the Russian Arctic. A July 10, 2020 news item on phys.org announces a new technology for mopping up oil spills (Note: Links have been removed),

Oil spill disasters on land cause long-term damage for communities and the natural environment, polluting soils and sediments and contaminating groundwater.

Current methods using synthetic sorbent materials can be effective for cleaning up oil spills, but these materials are often expensive and generate large volumes of non-biodegradable plastic wastes. Now the first comparison of natural-origin sorbent materials for land-based oil spills, including peat moss, recycled human hair, and dog fur, shows that sustainable, cheaper and biodegradable options can be developed.

The University of Technology Sydney (UTS) project found that dog fur and human hair products—recycled from salon wastes and dog groomers—can be just as good as synthetic fabrics at cleaning up crude oil spills on hard land surfaces like highway roads, pavement, and sealed concrete floors. Polypropylene, a plastic, is a widely-used fabric used to clean up oil spills in aquatic environments.

A July 9, 2020 Univesity of Technology Sydney press release on EurekAlert completes the story,

“Dog fur in particular was surprisingly good at oil spill clean-up, and felted mats from human hair and fur were very easy to apply and remove from the spills.” lead author of the study, UTS Environmental Scientist Dr Megan Murray, said. Dr Murray investigates environmentally-friendly solutions for contamination and leads The Phyto Lab research group at UTS School of Life Sciences.

“This is a very exciting finding for land managers who respond to spilled oil from trucks, storage tanks, or leaking oil pipelines. All of these land scenarios can be treated effectively with sustainable-origin sorbents,” she said.

The sorbents tested included two commercially-available products, propylene and loose peat moss, as well as sustainable-origin prototypes including felted mats made of dog fur and human hair. Prototype oil-spill sorbent booms filled with dog fur and human hair were also tested. Crude oil was used to replicate an oil spill. The results of the study are published in Environments.

The research team simulated three types of land surfaces; non-porous hard surfaces, semi-porous surfaces, and sand, to recreate common oil-spill scenarios.

“We found that loose peat moss is not as effective at cleaning up oil spills on land compared to dog fur and hair products, and it is not useful at all for sandy environments.” Dr Murray said.

“Based on this research, we recommend peat moss is no longer used for this purpose. Given that peat moss is a limited resource and harvesting it requires degrading wetland ecosystems, we think this is a very important finding.” she said.

The research concluded that, for now, sandy environments like coastal beaches can still benefit from the use of polypropylene sorbents, but further exploration of sustainable-origin sorbents is planned.

The researchers say that future applications from the research include investigating felted mats of sustainable-origin sorbents for river bank stabilisation, [emphases mine] as well as the removal of pollutants from flowing polluted waters, similar to existing membrane technology.

Here’s a link to and a citation for the study,

Decontaminating Terrestrial Oil Spills: A Comparative Assessment of Dog Fur, Human Hair, Peat Moss and Polypropylene Sorbents by Megan L. Murray, Soeren M. Poulsen and Brad R. Murray. Environments 2020, 7(7), 52; DOI: https://doi.org/10.3390/environments7070052 Published: 8 July 2020 (This article belongs to the Special Issue Pollution Prevention/Environmental Sustainability for Industry)

This paper is open access.

As for the Russian oil spill

A June 4, 2020 British Broadcasting Corporation (BBC) news online article outlines the situation regarding the oil spill and the steps being taken to deal with it,

Russia’s President Vladimir Putin has declared a state of emergency after 20,000 tonnes of diesel oil leaked into a river within the Arctic Circle.

The spill happened when a fuel tank at a power plant near the Siberian city of Norilsk collapsed last Friday [May 29, 2020].

The power plant’s director Vyacheslav Starostin has been taken into custody until 31 July, but not yet charged.

The plant is owned by a subsidiary of Norilsk Nickel, which is the world’s leading nickel and palladium producer.

The Russian Investigative Committee (SK) has launched a criminal case over the pollution and alleged negligence, as there was reportedly a two-day delay in informing the Moscow authorities about the spill.

Ground subsidence beneath the fuel storage tanks is believed to have caused the spill. Arctic permafrost has been melting in exceptionally warm weather [more information about the weather towards the end of this posting] for this time of year.

Russian Minister for Emergencies Yevgeny Zinichev told Mr Putin that the Norilsk plant had spent two days trying to contain the spill, before alerting his ministry.

The leaked oil drifted some 12km (7.5 miles) from the accident site, turning long stretches of the Ambarnaya river crimson red.

The leaked diesel oil drifted some 12km (7.5 miles) from the site of the accident [downloaded from https://www.bbc.com/news/world-europe-52915807]

Getting back to the June 4, 2020 British Broadcasting Corporation (BBC) news online article,

“Why did government agencies only find out about this two days [May 29, 2020?) after the fact?” he asked the subsidiary’s chief, Sergei Lipin. “Are we going to learn about emergency situations from social media?”

The region’s governor, Alexander Uss, had earlier told President Putin that he became aware of the oil spill on Sunday [May 31, 2020] after “alarming information appeared in social media”.

The spill has contaminated a 350 sq km (135 sq mile) area, state media report.

The state of emergency means extra forces are going to the area to assist with the clean-up operation.

The accident is believed to be the second largest in modern Russian history in terms of volume, an expert from the World Wildlife Fund, Alexei Knizhnikov, told the AFP [Agence France Presse] news agency.

The incident has prompted stark warnings from environmental groups, who say the scale of the spill and geography of the river mean it will be difficult to clean up.

Greenpeace has compared it to the 1989 Exxon Valdez disaster in Alaska.

Oleg Mitvol, former deputy head of Russia’s environmental watchdog Rosprirodnadzor, said there had “never been such an accident in the Arctic zone”.

He said the clean-up could cost 100bn roubles (£1.2bn; $1.5bn) and take between five and 10 years.

Minister of Natural Resources Dmitry Kobylkin warned against trying to burn off such a vast quantity of fuel oil.

He proposed trying to dilute the oil with reagents. Only the emergencies ministry with military support could deal with the pollution, he said.

Barges with booms could not contain the slick because the Ambarnaya river was too shallow, he warned.

He suggested pumping the oil on to the adjacent tundra, although President Putin added: “The soil there is probably saturated [with oil] already.”

An update of the situation can be found in a July 8, 2020 Canadian Broadcasting Corporation (CBC) article (issued by Thomson Reuters),

Russia’s environmental watchdog has asked a power subsidiary of Russian mining giant Norilsk Nickel to pay almost 148 billion rubles, or $2.8 billion Cdn, in damages over an Arctic fuel spill in Siberia.

Rosprirodnadzor, the Federal Service for Supervision of Use of Natural Resources, said in a statement on Monday [July 8, 2020] that it had already sent a request for “voluntary compensation” to the subsidiary, NTEK, after calculating the damage caused by the May 29 [2020] fuel spill.

Norilsk Nickel’s Moscow-listed shares fell by 3 per cent after the watchdog’s statement.

A fuel tank at the power plant lost pressure and released 21,000 tonnes of diesel into rivers and subsoil near the city of Norilsk, 2,900 kilometres northeast of Moscow. Russian President Vladimir Putin subsequently declared a state of emergency in the region, and investigators detained three staff at the power plant.

Norilsk, a remote city of 180,000 people situated 300 kilometres inside the Arctic Circle, is built around Norilsk Nickel, the world’s leading nickel and palladium producer, and has a reputation for its pollution.

Rosprirodnadzor said the damages included the cost for nearby water bodies, estimated at 147.05 billion rubles, $2.8 billion Cdn, and for subsoil, estimated at 738.62 million roubles, $14 million Cdn.

I can’t find any August 2020 updates for the oil spill situation in Russia. (Note: There is now an oil spill in a ecologically sensitive region near Mauritius; see August 13, 2020 news item on CBC news online website.)

Exceptionally warm weather

The oil spill isn’t the only problem in the Arctic.Here’s more from a June 23, 2020 article by Matt Simon for Wired magazine (Note: A link has been removed),

On Saturday [June 20, 2020], the residents of Verkhoyansk, Russia, marked the first day of summer with 100 degree Fahrenheit temperatures. Not that they could enjoy it, really, as Verkhoyansk is in Siberia, hundreds of miles from the nearest beach. That’s much, much hotter than towns inside the Arctic Circle usually get. That 100 degrees appears to be a record, well above the average June high temperature of 68 degrees. Yet it’s likely the people of Verkhoyansk will see that record broken again in their lifetimes: The Arctic is warming twice as fast as the rest of the planet—if not faster—creating ecological chaos for the plants and animals that populate the north.

“The events over the weekend—in the last few weeks, really—with the heatwave in Siberia, all are unprecedented in terms of the magnitude of the extremes in temperature,” says Sophie Wilkinson, a wildfire scientist at McMaster University who studies northern peat fires, which themselves have grown unusually frequent in recent years as temperatures climb.

The Arctic’s extreme warming, known as Arctic amplification or polar amplification, may be due to three factors. One, the region’s reflectivity, or albedo—how much light it bounces back into space—is changing as the world warms. “What we’ve been seeing over the last 30 years is some relatively dramatic declines in sea ice in the summertime,” says University of Edinburgh global change ecologist Isla Myers-Smith, who studies the Arctic.

Since ice is white, it reflects the sun’s energy, something you’re already probably familiar with when it comes to staying cool in the summer. If you had to pick the color of T-shirt to wear when going hiking on a hot day, she says, “most of us would pick the white T-shirt, because that’s going to reflect the sun’s heat off of our back.” Similarly, Myers-Smith says, “If the sea ice melts in the Arctic, that will remove that white surface off of the ocean, and what will be exposed is this darker ocean surface that will absorb more of the sun’s heat.”

If you’re interested in the environmental consequences of the warming of the Arctic, this is a very good article.

Finishing up, I wish the clean-up crews (in Russia and near Mauritius) all the best as they work in the midst of a pandemic, as well as, an environmental disaster (both the oil spill and the warming of the Arctic).

Get your curcumin delivered by nanoparticles

Curcumin is a constituent of turmeric (used in cooking and as a remedy in Ayurvedic medicine). It’s been a while since I’ve stumbled across a curcumin story (scientists have been trying to find a way to exploit its therapeutic qualities for years). The latest news comes from Australia, which is a little unexpected as most of the ‘curcumin research stories’ previously on this blog have come from India.

A March 5, 2020 news item on ScienceDaily announces new research on curcumin therapeutic possibilities,

For years, curry lovers have sworn by the anti-inflammatory properties of turmeric, but its active compound, curcumin, has long frustrated scientists hoping to validate these claims with clinical studies.

The failure of the body to easily absorb curcumin has been a thorn in the side of medical researchers seeking scientific proof that curcumin can successfully treat cancer, heart disease, Alzheimer’s and many other chronic health conditions.

Now, researchers from the University of South Australia (UniSA), McMaster University in Canada and Texas A&M University have shown that curcumin can be delivered effectively into human cells via tiny nanoparticles.

Over three years ago on December 2, 2016, researchers from McMaster University made this video about Alzheimer’s and curcumin research available,

From the McMaster University, Centre for Health Economics & Policy Analysis, December 2, 2016 news webpage,

This video investigates the therapeutic potential of curcumin, a substance found in turmeric, to prevent Alzheimer’s disease. The information presented in this video has integrated research including in vitro studies that aimed to observe the influence of curcumin based interventions in the neuropathology of Alzheimer’s disease. From mechanisms for neurogenesis to the disintegration of beta amyloid plaques, this video highlights that there are many pathways by which curcumin can elicit its effects. However, there are currently not enough human trials to support the mouse-model studies for turmeric’s ability to prevent Alzheimer’s.

Back to the latest work, a March 5, 2020 UniSA press release (also on EurekAlert), which originated the news item, describes curcumin research that focuses on STI’s (sexually transmitted infections), also mentioned is earlier work on Alzheimer’s Disease,

Sanjay Garg, a professor of pharmaceutical science at UniSA, and his colleague Dr Ankit Parikh are part of an international team that has developed a nano formulation which changes curcumin’s behaviour to increase its oral bioavailability by 117 per cent.

The researchers have shown in animal experiments that nanoparticles containing curcumin not only prevents cognitive deterioration but also reverses the damage. This finding paves the way for clinical development trials for Alzheimer’s.

Co-author Professor Xin-Fu Zhou, a UniSA neuroscientist, says the new formulation offers a potential solution for Alzheimer’s disease.

“Curcumin is a compound that suppresses oxidative stress and inflammation, both key pathological factors for Alzheimer’s, and it also helps remove amyloid plaques, small fragments of protein that clump together in the brains of Alzheimer disease patients,” Prof Zhou says.

The same delivery method is now being tested to show that curcumin can also prevent the spread of genital herpes.

“To treat genital herpes (HSV-2) you need a form of curcumin that is better absorbed, which is why it needs to be encapsulated in a nano formulation,” Prof Garg says.

“Curcumin can stop the genital herpes virus, it helps in reducing the inflammation and makes it less susceptible to HIV and other STIs,” Prof Garg says.

Women are biologically more vulnerable to genital herpes as bacterial and viral infections in the female genital tract (FGT) impair the mucosal barrier. Curcumin, however, can minimize genital inflammation and control against HSV-2 infection, which would assist in the prevention of HIV infection in the FGT.

Here’s a link to and a citation for the latest paper,

Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa by Danielle Vitali, Puja Bagri, Jocelyn M. Wessels, Meenakshi Arora, Raghu Ganugula, Ankit Parikh, Talveer Mandur, Allison Felker, Sanjay Garg, M.N.V. Ravi Kumar, and Charu Kaushic. Int. J. Mol. Sci. 2020, 21(1), 337; DOI: https://doi.org/10.3390/ijms21010337 Published: 4 January 2020

This is an open access paper and is part of the journal’s Special Issue Curcumin in Health and Disease: New Knowledge)

For anyone interested in the earlier work on Alzheimer’s Disease, here are links to two papers that were published in 2018 by a team led by Sanjay Garg,

Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability by Ankit Parikh, Krishna Kathawala, Yunmei Song, Xin-Fu Zhou & Sanjay Garg. Drug Delivery and Translational Research volume 8, pages 1389–1405 (2018) DOI: https://doi.org/10.1007/s13346-018-0543-3 Issue Date: October 2018

Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease by Ankit Parikh, Krishna Kathawala, Jintao Li, Chi Chen, Zhengnan Shan, Xia Cao, Xin-Fu Zhou & Sanjay Garg. Drug Delivery and Translational Research volume 8, pages 1406–1420 (2018) DOI: https://doi.org/10.1007/s13346-018-0570-0 Issue Date: October 2018

Neither of these paper is open access but you can gain access by contacting sanjay.garg@unisa.edu.au

This looks like exciting work, bearing in mind the latest curcumin research on an STI was performed on female mice. As for the Alzheimer’s papers, that curcumin research was also performed on animals, presumably mice. As the press release noted, “This finding paves the way for clinical development trials for Alzheimer’s.” Oddly, there’s no mention of clinical trials for STI’s.