Tag Archives: Andreas Hensel

FOE, nano, and food: part two of three (the problem with research)

The first part of this roughly six week food and nano ‘debate’ started off with the May 22, 2014 news item on Nanowerk announcing the Friends of the Earth (FOE) report ‘Way too little: Our Government’s failure to regulate nanomaterials in food and agriculture‘. Adding energy to FOE’s volley was a Mother Jones article written by Tom Philpott which had Dr. Andrew Maynard (Director of the University of Michigan’s Risk Science Center) replying decisively in an article published both on Nanowerk and on the Conversation.

Coincidentally or not, there were a couple of news items about ‘nano and food’ research efforts during the ‘debate’. A June 11, 2014 news item on Nanowerk highlights a Franco-German research project into the effects that nanomaterials have on the liver and the intestines while noting the scope of the task researchers face,

What mode of action do nanomaterials ingested via food have in liver and intestine? Which factors determine their toxicity? Due to the large number of different nanomaterials, it is hardly possible to test every one for its toxic properties. [emphasis mine] For this reason, specific properties for the classification of nanomaterials are to be examined within the scope of the Franco-German research project “SolNanoTox”, which began on 1 March 2014. The [German] Federal Institute for Risk Assessment (BfR) requires data on bioavailability for its assessment work, in particular on whether the solubility of nanomaterials has an influence on uptake and accumulation in certain organs, such as liver and intestine. “We want to find out in our tests whether the criterion ‘soluble or insoluble’ is a determining factor for uptake and toxicity of nanomaterials,” says BfR President Professor Dr. Andreas Hensel.

A June 13, 2014 German Federal Institute for Risk Assessment (BfR) press release, which originated the news item, details the research and the participating agencies,

A risk assessment of nanomaterials is hardly possible at the moment and involves a very high degree of uncertainty, as important toxicological data on their behaviour in tissue and cells are still missing. [emphasis mine] The German-French SolNanoTox research project examines which role the solubility of nanomaterials plays with regard to their accumulation and potential toxic properties. The project is to run for three and a half years during which the BfR will work closely with its French sister organisation ANSES. Other partners are the Institut des Sciences Chimiques de Rennes and Universität Leipzig. The German Research Foundation and French Agence Nationale de la Recherche (ANR) are funding the project.

The tasks of the BfR include in vitro tests (e.g. the investigation of the influence of the human gastrointestinal system) and analysis of biological samples with regard to the possible accumulation of nanomaterials. In addition to this, the BfR uses modern methods of mass spectrometry imaging to find out whether nanoparticles alter the structure of biomolecules, e.g. the structure of the lipids of the cellular membrane. So far, these important tests, which are necessary for assessing possible changes in DNA or cellular structures caused by nanomaterials in food, have not been conducted.

Metallic nanoparticles are to be studied (from the press release),

In the project, two fundamentally different types of nanoparticles are examined as representatives for others of their type: titanium dioxide as representative of water insoluble nanoparticles and aluminium as an example of nanomaterials which show a certain degree of water solubility after oxidation. [emphases mine] It is examined whether the degree of solubility influences the distribution of the nanomaterials in the body and whether soluble materials may possibly accumulate more in other organs than insoluble ones. The object is to establish whether there is a direct toxic effect of insoluble nanomaterials in general after oral uptake due to their small size.

Different innovative analytical methods are combined in the project with the aim to elucidate the behaviour of nanomaterials in tissue and their uptake into the cell. The main focus is on effects which can trigger genotoxic damage and inflammation. At first, the effects of both materials are examined in human cultures of intestinal and liver cells in an artificial environment (in vitro). In the following, it has to be verified by animal experimentation whether the observed effects can also occur in humans. This modus operandi allows to draw conclusions on effects and mode of action of orally ingested nanomaterials with different properties. The goal is to group nanomaterials on the basis of specific properties and to allocate the corresponding toxicological properties to these groups. Motivation for the project is the enormous number of nanomaterials with large differences in physicochemical properties. Toxicological tests cannot be conducted for all materials.

In the meantime, a June 19, 2014 news item on Azonano (also on EurekAlert but dated June 18, 2014) features some research into metallic nanoparticles in dietary supplement drinks,

Robert Reed [University of Arizona] and colleagues note that food and drink manufacturers use nanoparticles in and on their products for many reasons. In packaging, they can provide strength, control how much air gets in and out, and keep unwanted microbes at bay. As additives to food and drinks, they can prevent caking, deliver nutrients and prevent bacterial growth. But as nanoparticles increase in use, so do concerns over their health and environmental effects. Consumers might absorb some of these materials through their skin, and inhale and ingest them. What doesn’t get digested is passed in urine and feces to the sewage system. A handful of initial studies on nanomaterials suggest that they could be harmful, but Reed’s team wanted to take a closer look.

They tested the effects of eight commercial drinks containing nano-size metal or metal-like particles on human intestinal cells in the lab. The drinks changed the normal organization and decreased the number of microvilli, finger-like projections on the cells that help digest food. In humans, if such an effect occurs as the drinks pass through the gastrointestinal tract, these materials could lead to poor digestion or diarrhea, they say. The researchers’ analysis of sewage waste containing these particles suggests that much of the nanomaterials from these products are likely making their way back into surface water, where they could potentially cause health problems for aquatic life.

This piece is interesting for two reasons. First, the researchers don’t claim that metallic nanoparticles cause digestion or diarrhea due to any action in the gastrointestinal tract. They studied the impact that metallic nanoparticles in supplementary drinks had on cells (in vitro testing) from the gastrointestinal tract. Based on what they observed in the laboratory, “… these materials could lead to poor digestion or diarrhea… .” The researchers also suggest a problem could occur as these materials enter surface water in increasing quantities.

Here’s a link to and a citation for the paper,

Supplement Drinks and Assessment of Their Potential Interactions after Ingestion by Robert B. Reed, James J. Faust, Yu Yang, Kyle Doudrick, David G. Capco, Kiril Hristovski, and Paul Westerhoff. ACS Sustainable Chem. Eng., 2014, 2 (7), pp 1616–1624 DOI: 10.1021/sc500108m Publication Date (Web): June 2, 2014

Copyright © 2014 American Chemical Society

With Paul Westerhoff as one of the authors and the reference to metallic nanoparticles entering water supplies, I’m guessing that this research is associated with the LCnano (lifecycle nano) project headquartered at Arizona State university (April 8, 2014 posting).

Getting back to the Franco-German SolNanoTox project, scientists do not know what happens when the cells in your intestines, liver, etc. encounter metallic or other nanoparticles, some of which may be naturally occurring. It should also be noted that we have likely been ingesting metallic nanoparticles for quite some time. After all, anyone who has used silver cutlery has ingested some silver nanoparticles.

There are many, many questions to be asked and answered with regard to nanomaterials in our foods.  Here are a few of mine:

  • How many metallic and other nanoparticles did we ingest before the advent of ‘nanomaterials in food’?
  • What is the biopersistence of naturally occurring and engineered metallic and other nanoparticles in the body?
  • Is there an acceptable dose versus a fatal dose? (Note: There’s naturally occurring formaldehyde in pears as per my May 19, 2014 post about doses, poisons, and the Sense about Science group’s campaign/book, Making Sense of Chemical Stories.)
  • What happens as the metallic and other engineered nanoparticles are added to food and drink and eventually enter our water, air, and soil?

Returning to the ‘debate’, a July 11, 2014 article by Sarah Shemkus for a sponsored section in the UK’s Guardian newspaper highlights an initiative taken by an environmental organization, As You Sow, concerning titanium dioxide in Dunkin’ Donuts’ products (Note: A link has been removed),

The activists at environmental nonprofit As You Sow want you to take another look at your breakfast doughnut. The organization recently filed a shareholder resolution asking Dunkin’ Brands, the parent company of Dunkin’ Donuts, to identify products that may contain nanomaterials and to prepare a report assessing the risks of using these substances in foods.

Their resolution received a fair amount of support: at the company’s annual general meeting in May, 18.7% of shareholders, representing $547m in investment, voted for it. Danielle Fugere, As You Sow’s president, claims that it was the first such resolution to ever receive a vote. Though it did not pass, she says that she is encouraged by the support it received.

“That’s a substantial number of votes in favor, especially for a first-time resolution,” she says.

The measure was driven by recent testing sponsored by As You Sow, which found nanoparticles of titanium dioxide in the powdered sugar that coats some of the donut chain’s products. [emphasis mine] An additive widely used to boost whiteness in products from toothpaste to plastic, microscopic titanium dioxide has not been conclusively proven unsafe for human consumption. Then again, As You Sow contends, there also isn’t proof that it is harmless.

“Until a company can demonstrate the use of nanomaterials is safe, we’re asking companies either to not use them or to provide labels,” says Fugere. “It would make more sense to understand these materials before putting them in our food.”

As You Sow is currently having 16 more foods tested. The result should be available later this summer, Fugere says.

I wonder if As You Sow will address the question of whether the nanoscale titanium dioxide they find indicates that nanoscale particles are being deliberately added or whether the particles are the inadvertent consequence of the production process. That said, I find it hard to believe no one in the food industry is using engineered nanoscale additives as they claim  (the other strategy is to offer a nonanswer) in Shemkus’ article (Note: Links have been removed).,

In a statement, Dunkin’ Donuts argues that the titanium dioxide identified by As You Sow does not qualify as a nanomaterial according to European Union rules or draft US Food and Drug Administration regulations. The company also points out that there is no agreed-upon standard method for identifying nanoparticles in food.

In 2008, As You Sow filed nanomaterial labeling resolutions with McDonald’s and Kraft Foods. In response, McDonald’s released a statement declaring that it does not support the use of nanomaterials in its food, packaging or toys. Kraft responded that it would make sure to address health and safety concerns before ever using nanomaterials in its products.

While Shemkus’ article appears in the Guardian’s Food Hub which is sponsored by the Irish Food Board, this article manages to avoid the pitfalls found in Philpott’s nonsponsored article.

Coming next: the US Food and Drug Administration Guidance issued five weeks after the FOE kicks off the ‘nano and food’ debate in May 2014 with its ‘Way too little: Our Government’s failure to regulate nanomaterials in food and agriculture‘ report.

Part one (an FOE report is published)

Part three (final guidance)

Science Advice to Government; a global conference in August 2014

There’s a big science advice conference on the horizon for August 28 – 29, 2014 to be held in New Zealand according to David Bruggeman’s March 19, 2014 posting on his Pasco Phronesis blog (Note: Links have been removed),

… It [the global science advice conference] will take place in Auckland, New Zealand August 28 and 29 [2014].  It will be hosted by the New Zealand Chief Science Adviser, Sir Peter Gluckman.

(If you’re not following Sir Peter’s work and writings on science advice and science policy, you’re missing out.)

The announced panelists and speakers include chief scientists and/or chief science advisers from several countries and the European Union.  It’s a very impressive roster.  The conference is organised around five challenges:

  • The process and systems for procuring evidence and developing/delivering scientific      advice for government
  • Science advice in dealing with crisis
  • Science advice in the context of opposing political/ideological positions
  • Developing an approach to international science advice
  • The modalities of science advice: accumulated wisdom

The 2014 Science Advice to Governments; a global conference for leading practitioners is being organized by the International Council for Science. Here’s a list of the confirmed speakers and panellists (Note: Links have been removed),

We are delighted that the following distinguished scientists have confirmed their participation in the formal programme:

Prof. Shaukat Abdulrazak, CEO National Commission for Science, Technology and Innovation, Kenya

Dr. Ian Boyd, Chief Science Advisor, Department of Environment, Food and Rural Affairs (DEFRA) UK

Dr. Phil Campbell, Editor-in-Chief, Nature

Dr. Raja Chidambaram, Principal Scientific Advisor to the Government of India, and Chairman of the Scientific Advisory Committee to the Cabinet, India

Prof. Ian Chubb, Chief Scientist for Australia

Prof. Brian Collins, University College London’s Department of Science, Technology, Engineering and Public Policy (UCL STEaPP)

Dr. Lourdes J Cruz, President of the National Research Council of the Philippines and National Scientist

Prof. Heather Douglas, Chair in Science & Society, Balsillie School of International Affairs, U. of Waterloo Canada

Prof. Mark Ferguson, Chief Scientific Adviser to the Government of Ireland, and Director General, Science Foundation Ireland

Prof. Anne Glover, Chief Science Adviser to the President of the European Commission

Sir Peter Gluckman, Prime Minister’s Chief Science Advisor, New Zealand

Dr. Jörg Hacker, President of the German Academy of Sciences – Leopoldina; Member of UN Secretary General’s Scientific Advisory Board

Dr. Yuko Harayama, Executive member of Council for Science and Technology Policy, Cabinet Office of Japan; Member of UN Secretary General’s Scientific Advisory Board; former Deputy Director OECD Directorate for Science, Technology and Industry

Prof. Andreas Hensel, President of the Federal Institute for Risk Assessment (BfR), Germany

Prof. Gordon McBean, President-elect, International Council for Science (ICSU)

Prof. Romain Murenzi, Executive Director of The World Academy of Sciences (TWAS)

Dr. Mary Okane, Chief Scientist and Engineer, New South Wales Australia

Prof. Remi Quirion, Chief Scientist, Province of Quebec, Canada

Chancellor Emeritus Kari Raivio, Council of Finnish Academies, Finland

Prof. Nils Chr. Stenseth, President of the Norwegian Academy of Science and Letters and President of the International Biological Union (IUBS)

Dr. Chris Tyler, Director of the Parliamentary Office of Science and Technology (POST) in UK

Sir Mark Walport, Chief Scientific Advisor to the Government of the UK

Dr. James Wilsdon, Professor of Science and Democracy, University of Sussex, UK

Dr. Steven Wilson, Executive Director, International Council for Science (ICSU)

Dr. Hamid Zakri, Science Advisor to the Prime Minister of Malaysia; Member of UN Secretary General’s Scientific Advisory Board

I noticed a couple of Canadian representatives (Heather Douglas, Chair in Science & Society at the University of Waterloo, and Remi Quirion, Chief Scientist, province of Québec) on the list. We don’t have any science advisors for the Canadian federal government but it seems they’ve instituted some such position for the province of Québec. In lieu of a science advisor, there is the Council of Canadian Academies, which “is an independent, not-for-profit organization that supports independent, authoritative, and evidence-based expert assessments that inform public policy development in Canada” (from their About page).

One other person should be noted (within the Canadian context), James Wilsdon is a member of the Expert Panel for the Council of Canadian Academies’ still-in-progress assessment, The State of State of Canada’s Science Culture. (My Feb. 22, 2013 posting about the assessments provides a lengthy discourse about the assessment and my concerns about both it and the panel.)

Getting back to this meeting in New Zealand, the organizers have added a pre-conference symposium on science diplomacy (from the Science and Diplomacy webpage), Note: A link has been removed,

We are pleased to announce the addition of a pre-conference symposium to our programme of events. Co-chaired by Dr. Vaughan Turekian, Editor-in-Chief of the AAAS Journal Science and Diplomacy, and the CE of New Zealand Ministry of Foreign Affairs and Trade, this symposium will explore ‘the place of science in foreign ministries’.

Overview of the symposium

The past decade has seen unprecedented interested in the interface between science and diplomacy from a number of perspectives including:

– Diplomacy for Science – building international relationships to foster robust collaborative scientific networks and shared expertise and infrastructure;
– Science for Diplomacy – the science enterprise as a doorway to relationship building between nations with shared goals and values;
– Science in Diplomacy – the role of science in various diplomatic endeavours (e.g.: verification of agreements on climate change, nuclear treaties etc; in support of aid projects; in promoting economic and trade relationships; and in various international agreements and instruments such as phyto-sanitary regulations, free trade agreements, biodiversity agreements etc.).

Yet, despite the growing interest in this intersection, there has been little discussion of the practical realities of fostering the rapprochement between two very distinct professional cultures and practices, particularly with specific reference to the classical pillars of foreign policy: diplomacy; trade/economic; and aid. Thus, this pre-conference symposium will be focusing on the essential question:

How should scientists have input into the operation of foreign ministries and in particular into three pillars of foreign affairs (diplomacy, trade/economics and foreign aid)?

The discussion will focus on questions such as: What are the mechanisms and methods that can bring scientists and policy makers in science and technology in closer alignment with ministries or departments of foreign affairs and vice versa? What is the role of public scientists in assisting countries’ foreign policy positions and how can this be optimised? What are the challenges and opportunities in enhancing the role of science in international affairs? How does the perception of science in diplomacy vary between large and small countries and between developed and developing countries?

To ensure vibrant discussion the workshop will be limited to 70 participants. Anyone interested is invited to write to info@globalscienceadvice.org with a request to be considered for this event.

The conference with this newly added symposium looks to be even more interesting than before. As for anyone wishing to attend the science diplomacy symposium, the notice has been up since March 6, 2014 so you may wish to get your request sent off while there’s still space (I assume they’ll put a notice on the webpage once the spaces are spoken for). One final observation, it’s surprising in a science conference of this size that there’s no representation from a US institution (e.g., the National Academy of Sciences, Harvard University, etc.) other than the AAAS (American Association for the Advancement of Science) organizer of the pre-conference symposium.

Nanosilver risk assessment in Germany and a new approach to risk assessment suggested at Univ. of Michigan

There’s a move to ban the use of nanosilver in food and articles used daily (think of the socks you don’t have to wash very often because they don’t smell) in Germany until there’s been a full risk assessment. From the April 14, 2011 news item on Nanowerk,

In its opinion on toxicity aspects of nano silver, the Federal Institute for Risk Assessment (BfR) had recommended to waive the use of nano silver in foods and articles of daily use until the data situation allows for a final assessment of the health risks. Mainly industry objected to this assessment by BfR that enough data were available for the evaluation of the health risks of nano silver in consumer products and foods. For that reason BfR had invited experts from research and science as well as representatives of associations and industry to a workshop in order to discuss existing risks and possible options for a comprehensive consumer protection. “The discussion confirmed the words of caution of BfR”, said BfR President Professor Dr. Dr. Andreas Hensel, “because the situation continues to be characterised by the fact that not enough secured scientific findings about the specific effects of nano-sized silver particles are available.

” Metallic silver and different silver compounds are used, for instance, in cosmetic agents as well as in different consumer products, mainly because of their anti-microbial effect. For textiles not only medical/therapeutic applications but increasingly also hygiene aspects play a role. The anti-microbial finishing of textile fibres is mainly to act against odour formation as a result of the microbial decomposition of sweat. In the meantime nano-sized silver particles are increasingly being used. Nano particles are particles with a diameter of less than 100 nanometres.

This is interesting in light of yesterday’s April 14, 2011 posting about the European Commission’s attempts to establish a definition for nanomaterials before any attempts to regulate their use. Then today I came across a posting by Dr. Andrew Maynard, Director of the Risk Science Center at the University of Michigan, Ann Arbor titled Why we don’t need a regulatory definition for nanomaterials. His comments represent a significant shift in opinion since I first started following his work in 2007,

Engineered nanomaterials present regulators with a conundrum – there is a gut feeling that these materials present a new regulatory challenge, yet the nature and resolution of this challenge remains elusive. But as the debate over the regulation of nanomaterials continues, there are worrying signs that discussions are being driven less by the science of how these materials might cause harm, and more by the politics of confusion and uncertainty.

Yet the more we learn about how materials interact with biology, the less clear it becomes where the boundaries of this class of materials called “nanomaterials” lie, or even whether this is a legitimate class of material at all from a regulatory perspective.

In an evidence-driven society, now would be the time to take stock – to ask what the science tells us about risks associated with exposure to materials more generally, and to reformulate the problems we are trying to address when it comes to nanomaterials. But increasingly, evidence is taking a backstage role in the process of developing definitions for regulatory purposes. This was highlighted recently by Henrik Laursen [quoted in my April 14, 2011 posting] , coordinator of the nano team in the European Commission’s environment department, who was reported on Euractiv.com as stating that ultimately, the decision on a regulatory definition of nanomaterials would be a policy decision.

This should ring alarm bells throughout the scientific community.

Andrew has been heavily involved with the nanotechnology effort and discussion for many years. This is the biographical information available from his faculty page (it is by no means comprehensive),

Prof. Maynard is a leading authority on the responsible development and use of emerging technologies. His research interests span identifying, assessing and managing emergent risks, to exploring innovative solutions to established and emerging human health and environmental risks, to equipping people with the tools they need to make informed decisions in the face of risk and uncertainty. Prof. Maynard is a member of the World Economic Forum Global Agenda Council on the Challenges of Emerging Technologies, serves on numerous review and advisory panels around the world, and has testified on a number of occasions before U.S. Congressional committees.

Andrew explains why his ideas about regulation changed and how he wants to approach it,


Five years ago, the state of the science was such that it still seemed feasible that a regulatory definition of nanomaterials could be crafted. Today, that hope is looking increasingly tenuous. We know that size matters when it comes to understanding the risks presented by materials generally – and particles more specifically – and that characteristics such as physical form and chemistry are also important. But these are relevant from diameters of tens of micrometers – where particles begin to be able to penetrate organisms – down to the nanometer size range. At different length scales, different material-biology interactions lead to different mechanisms of action that have the potential to cause harm in different ways. But there are no rules that are generalizeable to the nanoscale specifically – that much the science is clear on. And this alone calls into question the scientific-basis of enforcing nanoscale-specific regulations.

Rather, the science suggests that we have a bigger task in hand – how do we develop a better understanding of how any particle capable of entering or otherwise interacting with an organism might cause harm, and how do we codify this in evidence-based guidelines that will inform regulation?

Here’s his proposal in a nutshell,

Difficult as it may be given the momentum of current efforts to define nanomaterials for regulatory purposes, now is the time to shift toward evidence-based regulation of sophisticated materials.

Andrew has written a paper about this proposal along with David B. Warheit and Martin A. Philbert, The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond (behind a paywall), in the journal Toxicological Sciences, (2011) 120 (suppl 1): S109 – S129, doi: 10.1093/toxsci/kfq372, in 50th Anniversary Issue.

I am intrigued but not yet convinced. I really must make time to read the paper. In any event, I encourage you to read Andrew’s full posting on the topic.