Category Archives: nanotechnology

Altered virus spins gold into beads

They’re not calling this synthetic biology but I’ m pretty sure that altering a virus gene so the virus can spin gold (Rumpelstiltskin anyone?) qualifies. From an August 24, 2018 news item on ScienceDaily,

The race is on to find manufacturing techniques capable of arranging molecular and nanoscale objects with precision.

Engineers at the University of California, Riverside, have altered a virus to arrange gold atoms into spheroids measuring a few nanometers in diameter. The finding could make production of some electronic components cheaper, easier, and faster.

An August 23, 2018 University of California at Riverside (UCR) news release (also on EurekAlett) by Holly Ober, which originated the news item, adds detail,

“Nature has been assembling complex, highly organized nanostructures for millennia with precision and specificity far superior to the most advanced technological approaches,” said Elaine Haberer, a professor of electrical and computer engineering in UCR’s Marlan and Rosemary Bourns College of Engineering and senior author of the paper describing the breakthrough. “By understanding and harnessing these capabilities, this extraordinary nanoscale precision can be used to tailor and build highly advanced materials with previously unattainable performance.”

Viruses exist in a multitude of shapes and contain a wide range of receptors that bind to molecules. Genetically modifying the receptors to bind to ions of metals used in electronics causes these ions to “stick” to the virus, creating an object of the same size and shape. This procedure has been used to produce nanostructures used in battery electrodes, supercapacitors, sensors, biomedical tools, photocatalytic materials, and photovoltaics.

The virus’ natural shape has limited the range of possible metal shapes. Most viruses can change volume under different scenarios, but resist the dramatic alterations to their basic architecture that would permit other forms.

The M13 bacteriophage, however, is more flexible. Bacteriophages are a type of virus that infects bacteria, in this case, gram-negative bacteria, such as Escherichia coli, which is ubiquitous in the digestive tracts of humans and animals. M13 bacteriophages genetically modified to bind with gold are usually used to form long, golden nanowires.

Studies of the infection process of the M13 bacteriophage have shown the virus can be converted to a spheroid upon interaction with water and chloroform. Yet, until now, the M13 spheroid has been completely unexplored as a nanomaterial template.

Haberer’s group added a gold ion solution to M13 spheroids, creating gold nanobeads that are spiky and hollow.

“The novelty of our work lies in the optimization and demonstration of a viral template, which overcomes the geometric constraints associated with most other viruses,” Haberer said. “We used a simple conversion process to make the M13 virus synthesize inorganic spherical nanoshells tens of nanometers in diameter, as well as nanowires nearly 1 micron in length.”

The researchers are using the gold nanobeads to remove pollutants from wastewater through enhanced photocatalytic behavior.

The work enhances the utility of the M13 bacteriophage as a scaffold for nanomaterial synthesis. The researchers believe the M13 bacteriophage template transformation scheme described in the paper can be extended to related bacteriophages.

Here’s a link to and a citation for the paper,

M13 bacteriophage spheroids as scaffolds for directed synthesis of spiky gold nanostructures by Tam-Triet Ngo-Duc, Joshua M. Plank, Gongde Chen, Reed E. S. Harrison, Dimitrios Morikis, Haizhou Liu, and Elaine D. Haberer. Nanoscale, 2018,10, 13055-13063 DOI: 10.1039/C8NR03229G First published on 25 Jun 2018

This paper is behind a paywall.

For another example of genetic engineering and synthetic biology, see my July 18, 2018 posting: Genetic engineering: an eggplant in Bangladesh and a synthetic biology grant at Concordia University (Canada).

For anyone unfamiliar with the Rumpelstiltskin fairytale about spinning straw into gold, see its Wikipedida entry.

Science and the 2019 Canadian federal government budget

There’s been a lot of noise about how the 2019 Canadian federal government budget is designed to please the various constituencies that helped bring the Liberal party back into power in 2015 and which the Liberals are hoping will help re-elect them later in 2019. I don’t care about that, for me, it’s all about the science.

In general, it seems the budget excitement is a bit milder than usual and some of that possibly due to the SNC-Lavalin (a huge Canadian engineering and construction firm) scandal resulting in the loss of two cabinet ministers, Trudeau’s top personal/political advisor, and Canada’s top bureaucrat; a 3rd reshuffling of Trudeau’s cabinet in less than three months; and the kind of political theatrics from the Liberals, the Conservatives, and the NDP (New Democratic Party) that I associate more strongly with our neighbours to the south. .

(As for the SNC-Lavalin mess which includes allegations of political interference on behalf of a company accused of various offences, you might find this brief March 11, 2019 article by David Ljunggren for Reuters insightful as it reviews the response from abroad, specifically, the OECD [Organization for Economic Cooperation and Development. For anyone who wants an overview and timeline of the crisis, there’s this March 10, 2019 news item on Huffington Post Canada and, for context, there’s this March 10, 2019 video report (roughly 3 mins.) on SNC-Lavalin’s long history of corruption by Daniel Tencer for Huffington Post Canada. )

In any event, it’s a been a very busy first quarter for 2019 and the science funding portion of the budget holds a few rays of light but in the main, the science funding portion suggests the government is treading water (term to describe a swimmer who is keeping their head above water and staying in place while being vertical). As for the rest of the 2019 budget, I leave to experience political pundits.

Let’s start with the sections that gladdened my heart, just a little.

Rays of light

We’re in Chapter 2 of the 2019 federal budget, in Part 5: Building a Nation of Innovators; Bringing Innovation to Regulations, and I’m happy to see this, as I think it’s absolutely essential that we become more innovative with regulations when emerging technologies pose new challenges at an ever increasing pace (Note: The formatting has been changed),

Simply put, regulations are rules that stipulate how businesses must operate. When they are effective, they contribute to the protection of health, safety, security and the environment. They also support innovation, productivity and competition by establishing the rules for fair markets and a predictable environment for businesses, reducing barriers to trade and fostering new investment. While the OECD [Organization for Economic Cooperation and Development] Regulatory Policy Outlook (2018) has again ranked Canada in the top five jurisdictions on many key measures of regulatory governance, recent reports from panels convened to advise the Government, such as the Advisory Council on Economic Growth and the Economic Strategy Tables, have called for Canada to take steps to change how we design and administer regulations. The Government is responding.

In Budget 2018, the Government announced its intention to review regulatory requirements and practices that impede innovation and growth in the following high-growth sectors:

Agri-food and aquaculture.
Health and bio-sciences.
Transportation and infrastructure.

The 2018 Fall Economic Statement continued this work, proposing additional ways to reform and modernize federal regulations, with an emphasis on making it easier for businesses to grow while continuing to protect Canadians’ health and safety and the environment. As a next step, Budget 2019 introduces the first three “Regulatory Roadmaps” to specifically address stakeholder issues and irritants in these sectors, informed by over 140 responses from businesses and Canadians across the country, as well as recommendations from the Economic Strategy Tables.

Introducing Regulatory Roadmaps

These Roadmaps lay out the Government’s plans to modernize regulatory frameworks, without compromising our strong health, safety, and environmental protections. They contain proposals for legislative and regulatory amendments as well as novel regulatory approaches to accommodate emerging technologies, including the use of regulatory sandboxes and pilot projects—better aligning our regulatory frameworks with industry realities.

Budget 2019 proposes the necessary funding and legislative revisions so that regulatory departments and agencies can move forward on the Roadmaps, including providing the Canadian Food Inspection Agency, Health Canada and Transport Canada with up to $219.1 million over five years, starting in 2019–20, (with $0.5 million in remaining amortization), and $3.1 million per year on an ongoing basis.

In the coming weeks, the Government will be releasing the full Regulatory Roadmaps for each of the reviews, as well as timelines for enacting specific initiatives, which can be grouped in the following three main areas:

What Is a Regulatory Sandbox? Regulatory sandboxes are controlled “safe spaces” in which innovative products, services, business models and delivery mechanisms can be tested without immediately being subject to all of the regulatory requirements.
– European Banking Authority, 2017

1. Creating a user-friendly regulatory system:
The Roadmaps propose a more user-friendly regulatory system, including the use of more digital services (e.g. online portals, electronic templates), and clearer guidance for industry so that innovative and safe products are available for Canadians more quickly.

2. Using novel or experimental approaches:
The Roadmaps propose greater exploration, innovation, and the use of sandboxes and pilot programs for new and innovative products. This will allow these products to be approved for use in a risk-based and flexible way—encouraging ongoing innovation while continuing to protect Canadians’ health and safety, and the environment.

3. Facilitating greater cooperation and reducing duplication:
The Roadmaps propose greater alignment and coordination within the federal government and across Canadian and international jurisdictions.

Real Improvements for Business

Digitizing Canadian Food Inspection Agency services
The Canadian Food Inspection Agency currently relies on a paper-based system for issuing export certificates. As a result, Canadian exporters are required to submit forms by mail and wait for those forms to be returned prior to exporting their products. When Canadian firms are allowed to complete the application process online and have their reviewed forms returned electronically, Canadian business owners will be able to export their products more rapidly.

Updating the Canadian grains legislative and regulatory frameworks
The Canada Grain Act has not been substantially updated in decades, and its requirements are not aligned with current market realities. A broad-based review of the Act, and of the operations of the Canadian Grain Commission, will be undertaken to address a number of issues raised by the Canadian grain industry, including redundant inspections and issues within the current grain classification process that unnecessarily restrict Canadian grain exporters.

Establishing a regulatory sandbox for new and innovative medical products
The regulatory approval system has not kept up with new medical technologies and processes. Health Canada proposes to modernize regulations to put in place a regulatory sandbox for new and innovative products, such as tissues developed through 3D printing, artificial intelligence, and gene therapies targeted to specific individuals.

Modernizing the regulation of clinical trials
Industry and academics have expressed concerns that regulations related to clinical trials are overly prescriptive and inconsistent. Health Canada proposes to implement a risk-based approach to clinical trials to reduce costs to industry and academics by removing unnecessary requirements for low-risk drugs and trials. The regulations will also provide the agri-food industry with the ability to carry out clinical trials within Canada on products such as food for special dietary use and novel foods.

Enhancing the road safety transfer payment program
Road safety and transportation requirements vary among Canadian provinces and territories, creating barriers and inefficiencies for businesses that transport goods by road. Transport Canada will support provinces and territories in working towards improved alignment of these requirements, including for the use of autonomous and connected vehicles. Funding would be made available to other stakeholders, such as academia and industry associations, to identify innovative road safety options, including for emerging technologies.

Introducing a regulatory sandbox for dangerous goods electronic shipping documents
Currently, shipments of dangerous goods in Canada must be accompanied by paper documentation which can be burdensome and inefficient for businesses. Under this initiative, Transport Canada would work with industry, American counterparts and provincial/territorial jurisdictions to identify options for the sharing of shipping documents by electronic means, based on existing technologies.

Removing federal barriers to the interprovincial trade of alcohol
To facilitate internal trade, the Government intends to remove the federal requirement that alcohol moving from one province to another be sold or consigned to a provincial liquor authority. Provinces and territories would continue to be able to regulate the sale and distribution of alcohol within their boundaries.

To ensure that these Roadmaps can be implemented in a timely manner, Budget 2019 proposes to provide up to $67.8 million over five years, starting in 2019–20, for Justice Canada resources. These funds will strengthen the Government’s capacity to draft the legislative and regulatory changes needed to facilitate a new approach to regulations in these sectors and others.

Harmonizing Regulations
When regulations are more consistent between jurisdictions, Canadian companies are better able to trade within Canada and beyond, while also giving Canadian consumers greater choice. The Government is working with provinces and territories to better harmonize regulations across provincial and territorial boundaries, opening up the door to more seamless internal trade. Canada also has an opportunity to harmonize regulations with its international trading partners, making Canada an even more attractive place to invest in and grow a business. The Government does this through a number of regulatory cooperation bodies, for example, the Canadian Free Trade Agreement Regulatory Reconciliation and Cooperation Table, the Canada-U.S. Regulatory Cooperation Council and the Regulatory Cooperation Forum of the Canada-European Union Comprehensive Economic and Trade Agreement.  

Budget 2019 proposes to provide $3.1 million per year in ongoing funding to the Treasury Board Secretariat, starting in 2020–21, to support its leadership of the Government’s regulatory cooperation priorities at home and abroad.

Modernizing Regulations
In the 2018 Fall Economic Statement, the Government announced its plan to introduce an annual modernization bill consisting of legislative amendments to various statutes to help eliminate outdated federal regulations and better keep existing regulations up to date. In Budget 2019, the Government proposes to introduce legislation to begin this work. Work also continues to identify opportunities to make regulatory efficiency and economic growth a permanent part of regulators’ mandates, while continuing to prioritize health and safety and environmental responsibilities.

As part of these ongoing efforts, the President of Treasury Board will announce shortly the establishment of an External Advisory Committee on Regulatory Competitiveness, which will bring together business leaders, academics and consumer representatives from across the country, to help identify opportunities to streamline regulations and for novel regulatory approaches as well as to advise the Government on other sectors for consideration in the next round of regulatory reviews. 

Safe Food for Canadians Regulations
A recent regulatory modernization success is related to the coming into force of the new Safe Food for Canadians Regulations in January 2019.These modern regulations apply across all sectors and have introduced an outcomes-based approach to food safety regulations.

The other ‘ray of light’ concerns high speed internet access. Interestingly, some of the text about high speed access echoes faintly echoes descriptions of Estonia’s perspective on this issue. (Note: Canada’s Treasury Board signed a memorandum of understanding with Estonia in May 2018 as per this May 29, 2018 article by Silver Tambur for estonian world (how estonians see it),

Canada and Estonia have signed a memorandum of understanding on digital cooperation, aiming to work together on joint projects.

The new partnership was signed during the Estonian prime minister, Jüri Ratas’s, visit to Ottawa on 28 May [2018]. Welcomed by his Canadian counterpart, Justin Trudeau, Ratas became the first Estonian prime minister to make an official visit to Canada.

Both countries already share a membership of Digital 7 – a network of leading digital governments, currently comprising Canada, Estonia, Israel, New Zealand, South Korea, United Kingdom and Uruguay. The group is seeking to harness digital technology and improve digital services for the benefit of its citizens.[emphasis mine]

Under the new cooperation agreement between Canada and Estonia, both countries will work together on joint projects, the exchange of experts and other ways to share good practices as well as concrete digital solutions to advance these priorities.

Of course, there’s no point to improving digital services for citizens who do not have high speed internet or much of any kind of connectivity, as the Estonians must have realized fairly early on. This excerpt from an Estonian tourist website has a scrap of text that bears a resemblance to text in the Canadian 2019 budget (from the homepage of visit estonia),

“e-Estonia”, the E is for electronic, has become the go to tag to describe Estonia’s immensely successful love affair with all things networked and digitised.

Country wide enthusiasm for the efficiency of E has enthralled both citizens and policymakers alike. Estonian programmers have been behind the creation of digital brands such as Skype, Hotmail and more recently Transferwise (a online currency converter which has attracted investment from the likes of Richard Branson). Estonia has declared internet access a human right, [emphasis mine] it has a thriving IT start up culture and has digitally streamlined an unprecedented number of public services for citizens and businesses.

The roots of this revolution began in 1991, the year of Estonian independence, Estonian policy makers were given the rare gift of a bureaucratic clean slate. Placing their faith in the burgeoning possibilities of the internet and value of innovation, they steered the country into a position where it could leapfrog to become one of the most advanced e-societies in the world.

Now, here’s what the 2019 federal budget had to say bout connectivity in Canada (from Chapter 2; Part 3: Connecting Canadians), Note: Formatting has been changed),

Access to High-Speed Internet for All Canadians

In 2019, fast and reliable internet access is no longer a luxury—it’s a necessity. [emphasis mine]

For public institutions, entrepreneurs, and businesses of all sizes, quality high-speed internet is essential to participating in the digital economy—opening doors to customers who live just down the street or on the other side of the world. It is also important in the lives of Canadians. It lets students and young people do their homework, stay in touch with their friends, and apply for their very first jobs. It helps busy families register for recreational programs, shop online and pay their bills and access essential services. For many seniors, the internet is a way to stay up on current events and stay connected to distant family members and friends.

Canadians have a strong tradition of embracing new technologies, and using them to help generate long-term economic growth and drive social progress. In recent years, Canada and Canadian companies built mobile wireless networks that are among the fastest in the world and made investments that are delivering next-generation digital technologies and services to people and communities across the country. Yet, unfortunately, many Canadians still remain without reliable, high-speed internet access. In this time in the 21st Century, this is unacceptable.

How We Will Achieve a Fully Connected Canada

Delivering universal high-speed internet to every Canadian in the quickest and most cost-effective way will require a coordinated effort involving partners in the private sector and across all levels of government. To meet this commitment, Budget 2019 is proposing a new, coordinated plan that would deliver $5 billion to $6 billion in new investments in rural broadband over the next 10 years:

Support through the Accelerated Investment Incentive to encourage greater investments in rural high-speed internet from the private sector.
Greater coordination with provinces, territories, and federal arm’s-length institutions, such as the CRTC and its $750 million rural/remote broadband fund.
Securing advanced Low Earth Orbit satellite capacity to serve the most rural and remote regions of Canada.
New investments in the Connect to Innovate program and introduction of the Government’s new Universal Broadband Fund.
New investments by the Canada Infrastructure Bank to further leverage private sector investment.

Or, you could describe internet access as a human right. Whether you like it or not, it seems, short of a planetary disaster, internet access will be almost as important as food, water, and air.

This next ‘ray of light’ is a bit of a mixed bag, from Paul Wells’s March 19, 2019 article for Maclean’s,

… There’s $2.2 billion, refreshingly free of attached strings, in “much needed infrastructure funds” right now, this year.

Why infrastructure funds would still be “much needed,” four years into the tenure of the third prime minister in a row to make infrastructure spending a personal priority, is an interesting question for another day.

I’m hoping that at least some of this money is going to address the government’s digital infrastructure and I don’t understand any more than Paul Wells does as to why we’d still be talking about infrastructure. Stephen Harper’s Conservative government was in place for almost 10 years and Trudeau’s government for almost four years now (I don’t include Paul Martin’s government as that was fairly short lived) and with both of these prime ministers touting infrastructure, what’s taking so much time?

I hope some of this money is being dedicated to replacing the government’s dangerously aging digital infrastructure. I included some excerpts from an excellent article by James Bagnall on the state of the government’s digital infrastructure in my March 19, 2019 posting (scroll down about 15% of the way), which is a commentary on the Chief Science Advisor’s Office (CSO) 2018 annual report. Bagnall’s description is shocking and when I looked at the CSO’s 2018 report and saw that approximately 80% of the digital infrastructure for government science is conducted facilities that are between 50 and 25 years old with, presumably, similarly aged hardware and software, I couldn’t help but wonder when the Canadian government digital armageddon would occur.

I dug further into the 2019 budget and in Chapter Four, Part Six: Better Government found no mention of their digital infrastructure or of monies allocated to replacing any or all of the digital infrastructure. (sigh)

More happily, there was some reference to the Phoenix payroll system debacle and attempts to rectify the situation,

Ensuring Proper Payment for Public Servants

Canada’s public servants work hard in service of all Canadians and deserve to be paid properly and on time for their important work. The Phoenix pay system for federal public servants was originally intended to save money, however, since its launch it has resulted in unacceptable pay inaccuracies—resulting in hardships for public servants across the country. Serious issues and challenges with the pay system continue, and too many of Canada’s public servants are not being properly paid, or are waiting for their pay issues to be resolved.

To continue progress on stabilizing the current pay system, Budget 2019 provides an additional $21.7 million in 2018–19 to address urgent pay administration pressures (partially sourced from existing departmental funds), and proposes to invest an additional $523.3 million over five years, starting in 2019–20, to ensure that adequate resources are dedicated to addressing payroll errors. This investment will also support system improvements, to reduce the likelihood of errors occurring in the first place.

To ensure that the Canada Revenue Agency is able to quickly and accurately process income tax reassessments for federal government employees that are required due to Phoenix pay issues, and to support related telephone enquiries, Budget 2019 proposes to provide the Agency with an additional $9.2 million in 2019–20.

While the Phoenix pay system has been underpaying some public servants, it has also been paying others too much. Under current legislation, any employee who received an overpayment in a previous year is required to pay back the gross amount of this overpayment to their employer. The employee must recover from the Canada Revenue Agency the excess income tax, Canada Pension Plan contributions and Employment Insurance premiums that were deducted by their employer when the overpayment was made. On January 15, 2019, the Government proposed legislative amendments that would allow overpaid employees working in both the public and private sectors to repay their employer only the net amount they received after these deductions. The proposed amendments are intended to alleviate the burden faced by employees who were required to make repayments larger than the amounts they received from their employer, creating uncertainty and potential financial hardship.

Moving Toward the Next Generation Pay System for the Federal Public Service

In Budget 2018, the Government announced its intention to move away from the Phoenix pay system toward one better aligned to the complexity of the Government’s pay structure and to the future needs of Canada’s world-class public service.

Working cooperatively with experts, federal public sector unions, employees, pay specialists and technology providers, the Treasury Board Secretariat (TBS) launched a process to review lessons learned, and identify options for a next-generation pay solution.

As part of this process, pay system suppliers were invited to demonstrate possible solutions, which were directly tested with users. Based on feedback from users and participating stakeholders, TBS has been able to identify options with the potential to successfully replace the Phoenix pay system. As a next step, the Government will work with suppliers and stakeholders to develop the best options, including pilot projects that will allow for further testing with select departments and agencies, while assessing the ability of suppliers to deliver.

Finally, TBS will continue to engage public servants throughout this process, to ensure that their feedback is fully reflected in any future solution.

Interestingly, at the time of James Bagnoll’s article (excerpt in my March 19, 2019 posting), the only government data centre being replaced was Revenue Canada’s. It suggests that anything else can fall to pieces but the government should always be able to collect tax.

Getting back to my more cheerful and optimistic self, on balance, it’s encouraging to see thoughtful approaches to modernizing our regulatory system.

Treading water

There’s more to the’ 2019 commitment to science (from the 2019 budget’s Chapter 2; Part 6: Building Research Excellence in Canada: Support for Science, Research and Technology Organizations),

Canada is home to world-leading non-profit organizations that undertake research and bring together experts from diverse backgrounds to make discoveries, accelerate innovation and tackle health challenges. The Government helps support these collaborative efforts with targeted investments that return real economic and social benefits for Canadians.
Budget 2019 proposes to make additional investments in support of the following organizations:
Stem Cell Network: Stem cell research—pioneered by two Canadians in the 1960s—holds great promise for new therapies and medical treatments for respiratory and heart diseases, spinal cord injury, cancer, and many other diseases and disorders. The Stem Cell Network is a national not-for-profit organization that helps translate stem cell research into clinical applications and commercial products. To support this important work and foster Canada’s leadership in stem cell research, Budget 2019 proposes to provide the Stem Cell Network with renewed funding of $18 million over three years, starting in 2019–20.
Brain Canada Foundation: The Brain Canada Foundation is a national charitable organization that raises funds to foster advances in neuroscience discovery research, with the aim of improving health care for people affected by neurological injury and disease. To help the medical community better understand the brain and brain health, Budget 2019 proposes to provide the Brain Canada Foundation’s Canada Brain Research Fund with up to $40 million over two years, starting in 2020–21. This investment will be matched by funds raised from other non-government partners of the Brain Canada Foundation.
Terry Fox Research Institute: The Terry Fox Research Institute manages the cancer research investments of the Terry Fox Foundation. Budget 2019 proposes to provide the Terry Fox Research Institute with up to $150 million over five years, starting in 2019–20, to help establish a national Marathon of Hope Cancer Centres Network. The Institute would seek matching funding through a combination of its own resources and contributions that it would seek from other organizations,, including hospital and research foundations.
Ovarian Cancer Canada: Ovarian Cancer Canada supports women living with the disease and their families, raises awareness and funds research. Budget 2019 proposes to provide Ovarian Cancer Canada with $10 million over five years beginning in 2019–20 to help address existing gaps in knowledge about effective prevention, screening, and treatment options for ovarian cancer.
Genome Canada: The insights derived from genomics—the study of the entire genetic information of living things encoded in their DNA and related molecules and proteins—hold the potential for breakthroughs that can improve the lives of Canadians and drive innovation and economic growth. Genome Canada is a not-for-profit organization dedicated to advancing genomics science and technology in order to create economic and social benefits for Canadians. To support Genome Canada’s operations, Budget 2019 proposes to provide Genome Canada with $100.5 million over five years, starting in 2020–21. This investment will also enable Genome Canada to launch new large-scale research competitions and projects, in collaboration with external partners, ensuring that Canada’s research community continues to have access to the resources needed to make transformative scientific breakthroughs and translate these discoveries into real-world applications.
Let’s Talk Science: Science, technology, engineering and math (STEM) are not just things we study in school—together, they are transforming all aspects of our lives, and redefining the skills and knowledge people need to succeed in a changing world. Let’s Talk Science engages youth in hands-on STEM activities and learning programs, such as science experiments, helping youth develop critical thinking skills and opening up doors to future study and work in these fields. It also helps ensure more girls—and other groups that are underrepresented in STEM—gain and maintain interest in STEM from an early age. Budget 2019 proposes to provide Let’s Talk Science with $10 million over two years, starting in 2020–21, to support this important work.

There’s nothing earth shattering on that list. Five of these organizations could be described as focused on medical research and I have seen at least three of them mentioned in previous federal budgets. The last organization, Let’s Talk Science (established in 1993), focused on science promotion for children and youth, is being mentioned for the first time in a budget (as far as I know).

In the next section, the budget blesses physics or more specifically, TRIUMF. From the 2019 budget’s Chapter 2; Part 6: Building Research Excellence in Canada: Strengthening Canada’s World-Class physics research,

TRIUMF is a world-class sub-atomic physics research laboratory located in British Columbia, and home to the world’s largest cyclotron particle accelerator. TRIUMF has played a leading role in many medical breakthroughs—such as developing alongside Canadian industrial partners new approaches to the medical imaging of diseases—and brings together industry partners, leading academic researchers and scientists, and graduate students from across Canada and around the world to advance medical isotope production, drug development, cancer therapy, clinical imaging, and radiopharmaceutical research.

Budget 2019 proposes to provide TRIUMF with $195.9 million over five years, starting in 2019–20, to build on its strong track record of achievements. Combined with an additional $96.8 million from the existing resources of the National Research Council, federal support for TRIUMF will total $292.7 million over this five-year period.

When are the folks at the Canadian Light Source (our synchrotron) going to get some love? Year after year it’s either TRIUMF or the Perimeter Institute getting a major infusion of cash. I exaggerate but only mildly.You can find some of my comments on the 2018 federal budget in this March 16, 2018 posting and my comments on the 2017 federal budget in this March 24, 2017 posting.

Maybe one day a ray of light?

Here’s something new but I imagine you’ll quickly see what makes this an odd addition to the budget (from the 2019 budget’s Chapter 2; Part 6: Building Research Excellence in Canada: Taking a new approach With the Strategic Science Fund),

To make federal investments in third-party science and research more effective, Budget 2019 proposes to establish a new Strategic Science Fund. This new Fund will respond to recommendations that arose during consultations with third-party science and research organizations. It will operate using a principles-based framework for allocating federal funding that includes competitive, transparent processes. This will help protect and promote research excellence.

Under the Fund, the principles-based framework will be applied by an independent panel of experts, including scientists and innovators, who will provide advice for the consideration of the Government on approaches to allocating funding for third-party science and research organizations.

Budget 2019 proposes to establish and operate the Strategic Science Fund starting in 2022–23.

This Strategic Science Fund will be the Government’s key new tool to support third-party science and research organizations. Going forward, the selection of recipient organizations and corresponding level of support will be determined through the Fund’s competitive allocation process, with advice from the expert panel and informed by the Minister of Science’s overall strategy. The Minister of Science will provide more detail on the Fund over the coming months.

No money until 2022, eh? That’s interesting given that would be a year before the election (2023) after this one later in 2019. And, it’s anyone’s guess as to which government will be in power. Crossing my fingers again, I hope these good intention bear fruit in light of Daniel Banks’s (of the Canadian Neutron Beam Centre] March 21, 2019 essay (on the Canadian Science Policy Centre website) about the potential new oversight (Note: Prepare yourself for some alphabet soup; the man loves initialisms and sees no reason to include full names),

From a science policy perspective, which is about how science is managed, as well as funded, the biggest change may be one item that had no dollar amount attached.

Budget 2019 announces a “new approach” for funding so-called “third-party science and research.” The Fundamental Science Review defined “third-party science entities” as those operating outside the jurisdiction of NSERC, CIHR, SSHRC, CFI. Genome Canada, Mitacs, and Brain Canada are a few examples.

The Review raised concerns, not with the quality of these organizations’ output, but with how they are each governed as one-offs, via term-limited contribution agreements with ISED. Ad hoc governance arrangements have been needed until now because these organizations don’t fit within the existing programs of the granting councils. Lack of a suitable program required scientists to lobby for funds, rather than participate in peer-reviewed competitions. Over time, the Review warned, this approach could “allow select groups of researchers to sidestep the intensity of peer review competitions, and facilitate unchecked mission drift as third-party partner organizations shift their mandates to justify their continuation.”

The Strategic Science Fund could be a precedent for another portion of the science community that faces similar challenges: so-called Big Science, or Major Research Facilities (MRFs), such as TRIUMF, SNOLAB, Ocean Networks Canada, the Canadian Light Source, and large facilities for astronomy or neutron scattering. In the absence of a systematic means of overseeing Canada’s portfolio of these shared national resources, an array of oversight mechanisms have been created for these facilities on an ad hoc basis, much like the case for third-party research organizations. The Fundamental Science Review was the latest in a string of reports that have pointed problems with this ad hoc approach, stretching back at least 20 years.

Stewardship of Canada’s MRFs has improved following the introduction of the CFI’s Major Science Initiatives Fund in 2012, and the expansion of its mandate to include more facilities under its program in 2014. Nonetheless, there are still many facilities that are not covered by this Fund. No agency has responsibility for the entire portfolio of MRFs to allow it to plan for the creation of new MRFs as others wind-down, or provide predictable funding over the life-cycle of an MRF. Other MRFs still fall through jurisdictional cracks, where no federal agency is clearly responsible for them. Such jurisdictional cracks were one contributing factor in the loss of Canada’s neutron scattering facilities in 2018.

it’s one of the things I’ve found most difficult about following the Canadian science scene, it’s very scattered. In his essay, Banks explains, in part, why this situation exists.Let’s hope that one government or another addresses it.

On balance, it’s encouraging to see thoughtful approaches to modernizing our regulatory system and to better integrating the various agencies that serve our science initiatives. As for infrastructure and the Strategic Science Fund, I have, as previously noted, my fingers crossed. Let’s hope they manage it this time.

Change the shape of water with nanotubes

An August 24, 2018 news item on ScienceDaily describes a ‘shapeshifting’ water technique,

First, according to Rice University engineers, get a nanotube hole. Then insert water. If the nanotube is just the right width, the water molecules will align into a square rod.

Rice materials scientist Rouzbeh Shahsavari and his team used molecular models to demonstrate their theory that weak van der Waals forces between the inner surface of the nanotube and the water molecules are strong enough to snap the oxygen and hydrogen atoms into place.

Shahsavari referred to the contents as two-dimensional “ice,” because the molecules freeze regardless of the temperature. He said the research provides valuable insight on ways to leverage atomic interactions between nanotubes and water molecules to fabricate nanochannels and energy-storing nanocapacitors.

An August 24, 2018 Rice University news release (also on EurekAlert and received via email), which originated the news item, delves further,

Shahsavari and his colleagues built molecular models of carbon and boron nitride nanotubes with adjustable widths. They discovered boron nitride is best at constraining the shape of water when the nanotubes are 10.5 angstroms wide. (One angstrom is one hundred-millionth of a centimeter.)

The researchers already knew that hydrogen atoms in tightly confined water take on interesting structural properties. Recent experiments by other labs showed strong evidence for the formation of nanotube ice and prompted the researchers to build density functional theory models to analyze the forces responsible.

Shahsavari’s team modeled water molecules, which are about 3 angstroms wide, inside carbon and boron nitride nanotubes of various chiralities (the angles of their atomic lattices) and between 8 and 12 angstroms in diameter. They discovered that nanotubes in the middle diameters had the most impact on the balance between molecular interactions and van der Waals pressure that prompted the transition from a square water tube to ice.

“If the nanotube is too small and you can only fit one water molecule, you can’t judge much,” Shahsavari said. “If it’s too large, the water keeps its amorphous shape. But at about 8 angstroms, the nanotubes’ van der Waals force [if you’re not familiar with the term, see below the link and citation for my brief explanation] starts to push water molecules into organized square shapes.”

He said the strongest interactions were found in boron nitride nanotubes due to the particular polarization of their atoms.

Shahsavari said nanotube ice could find use in molecular machines or as nanoscale capillaries, or foster ways to deliver a few molecules of water or sequestered drugs to targeted cells, like a nanoscale syringe.

Lead author Farzaneh Shayeganfar, a former visiting scholar at Rice, is an instructor at Shahid Rajaee Teacher Training University in Tehran, Iran. Co-principal investigator Javad Beheshtian is a professor at Amirkabir University, Tehran.

Supercomputer resources were provided with support from the [US] National Institutes of Health and an IBM Shared Rice University Research grant.

Here’s a link to and a citation for the paper,

First Principles Study of Water Nanotubes Captured Inside Carbon/Boron Nitride Nanotubes by Farzaneh Shayeganfar, Javad Beheshtian, and Rouzbeh Shahsavari. Langmuir, DOI: 10.1021/acs.langmuir.8b00856 Publication Date (Web): August 23, 2018

Copyright © 2018 American Chemical Society

This paper is behind a paywall.

For the purposes of the posting, van der Waals force(s) are weak adhesive forces measured at the nanoscale. Humans don’t feel them (we’re too big) but gecko lizards can exploit those forces which is why they are able to hang from the ceiling by a single toe.  There’s a more informed description here in the van der Waals force entry on Wikipedia.

Researchers, manufacturers, and administrators need to consider shared quality control challenges to advance the nanoparticle manufacturing industry ‘

Manufacturing remains a bit of an issue where nanotechnology is concerned due to the difficulties of producing nanoparticles of a consistent size and type,


Electron micrograph showing gallium arsenide nanoparticles of varying shapes and sizes. Such heterogeneity [variation]  can increase costs and limit profits when making nanoparticles into products. A new NIST study recommends that researchers, manufacturers and administrators work together to solve this, and other common problems, in nanoparticle manufacturing. Credit: A. Demotiere, E. Shevchenko/Argonne National Laboratory

The US National Institute of Standards and Technology (NIST) has produced a paper focusing on how nanoparticle manufacturing might become more effective, from an August 22, 2018 news item on ScienceDaily,

Nanoparticle manufacturing, the production of material units less than 100 nanometers in size (100,000 times smaller than a marble), is proving the adage that “good things come in small packages.” Today’s engineered nanoparticles are integral components of everything from the quantum dot nanocrystals coloring the brilliant displays of state-of-the-art televisions to the miniscule bits of silver helping bandages protect against infection. However, commercial ventures seeking to profit from these tiny building blocks face quality control issues that, if unaddressed, can reduce efficiency, increase production costs and limit commercial impact of the products that incorporate them.

To help overcome these obstacles, the National Institute of Standards and Technology (NIST) and the nonprofit World Technology Evaluation Center (WTEC) advocate that nanoparticle researchers, manufacturers and administrators “connect the dots” by considering their shared challenges broadly and tackling them collectively rather than individually. This includes transferring knowledge across disciplines, coordinating actions between organizations and sharing resources to facilitate solutions.

The recommendations are presented in a new paper in the journal ACS Applied Nano Materials.

An August 22, 2018 NIST news release, which originated the news item, describes how the authors of the ACS [American Chemical Society) Applied Nano Materials paper developed their recommendations,

“We looked at the big picture of nanoparticle manufacturing to identify problems that are common for different materials, processes and applications,” said NIST physical scientist Samuel Stavis, lead author of the paper. “Solving these problems could advance the entire enterprise.”

The new paper provides a framework to better understand these issues. It is the culmination of a study initiated by a workshop organized by NIST that focused on the fundamental challenge of reducing or mitigating heterogeneity, the inadvertent variations in nanoparticle size, shape and other characteristics that occur during their manufacture.

“Heterogeneity can have significant consequences in nanoparticle manufacturing,” said NIST chemical engineer and co-author Jeffrey Fagan.

In their paper, the authors noted that the most profitable innovations in nanoparticle manufacturing minimize heterogeneity during the early stages of the operation, reducing the need for subsequent processing. This decreases waste, simplifies characterization and improves the integration of nanoparticles into products, all of which save money.

The authors illustrated the point by comparing the production of gold nanoparticles and carbon nanotubes. For gold, they stated, the initial synthesis costs can be high, but the similarity of the nanoparticles produced requires less purification and characterization. Therefore, they can be made into a variety of products, such as sensors, at relatively low costs.

In contrast, the more heterogeneous carbon nanotubes are less expensive to synthesize but require more processing to yield those with desired properties. The added costs during manufacturing currently make nanotubes only practical for high-value applications such as digital logic devices.

“Although these nanoparticles and their end products are very different, the stakeholders in their manufacture can learn much from each other’s best practices,” said NIST materials scientist and co-author J. Alexander Liddle. “By sharing knowledge, they might be able to improve both seemingly disparate operations.”

Finding ways like this to connect the dots, the authors said, is critically important for new ventures seeking to transfer nanoparticle technologies from laboratory to market.

“Nanoparticle manufacturing can become so costly that funding expires before the end product can be commercialized,” said WTEC nanotechnology consultant and co-author Michael Stopa. “In our paper, we outlined several opportunities for improving the odds that new ventures will survive their journeys through this technology transfer ‘valley of death.’”

Finally, the authors considered how manufacturing challenges and innovations are affecting the ever-growing number of applications for nanoparticles, including those in the areas of electronics, energy, health care and materials.

Here’s a link to and a citation for the paper,

Nanoparticle Manufacturing – Heterogeneity through Processes to Products by Samuel M. Stavis, Jeffrey A. Fagan, Michael Stopa, and J. Alexander Liddle. ACS Appl. Nano Mater., Article ASAP DOI: 10.1021/acsanm.8b01239 Publication Date (Web): August 16, 2018

Copyright © 2018 American Chemical Society

This paper is behind a paywall.

I looked at this paper briefly and found it to give a good overview. The focus is on manufacturing and making money. I imagine any discussion about the life cycle of the materials and possible environmental and health risks would have been considered ‘scope creep’.

I have two postings that provide additional information about manufacturing concerns, my February 10, 2014 posting:  ‘Valley of Death’, ‘Manufacturing Middle’, and other concerns in new government report about the future of nanomanufacturing in the US and my September 5, 2016 posting: An examination of nanomanufacturing and nanofabrication.

Structural colo(u)r from transparent 3D printed nanostructures

Caption: Light hits the 3-D printed nanostructures from below. After it is transmitted through, the viewer sees only green light — the remaining colors are redirected. Credit: Thomas Auzinger [downloaded from http://visualcomputing.ist.ac.at/publications/2018/StructCol/]

An August 17, 2018 news item on ScienceDaily announces the work illustrated by the image above,

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and certain color effects are impossible to achieve. The natural world, however, also exhibits structural coloration, where the microstructure of an object causes various colors to appear. Peacock feathers, for instance, are pigmented brown, but — because of long hollows within the feathers — reflect the gorgeous, iridescent blues and greens we see and admire. Recent advances in technology have made it practical to fabricate the kind of nanostructures that result in structural coloration, and computer scientists from the Institute of Science and Technology Austria (IST Austria) and the King Abdullah University of Science and Technology (KAUST) have now created a computational tool that automatically creates 3D-print templates for nanostructures that correspond to user-defined colors. Their work demonstrates the great potential for structural coloring in industry, and opens up possibilities for non-experts to create their own designs. This project will be presented at this year’s top computer graphics conference, SIGGRAPH 2018, by first author and IST Austria postdoc Thomas Auzinger. This is one of five IST Austria presentations at the conference this year.

SIGGRAPH 2018, now ended, was mentioned in my Aug. 9, 2018 posting.but since this presentation is accompanied by a paper, it rates its own posting. For one more excuse, there’s my fascination with structural colour.

An August 17, 2018 Institute of Science and Technology Austria press release (also on EurekAlert), which originated the news item, delves into the work,

The changing colors of a chameleon and the iridescent blues and greens of the morpho butterfly, among many others in nature, are the result of structural coloration, where nanostructures cause interference effects in light, resulting in a variety of colors when viewed macroscopically. Structural coloration has certain advantages over coloring with pigments (where particular wavelengths are absorbed), but until recently, the limits of technology meant fabricating such nanostructures required highly specialized methods. New “direct laser writing” set-ups, however, cost about as much as a high-quality industrial 3D printer, and allow for printing at the scale of hundreds of nanometers (hundred to thousand time thinner than a human hair), opening up possibilities for scientists to experiment with structural coloration.

So far, scientists have primarily experimented with nanostructures that they had observed in nature, or with simple, regular nanostructural designs (e.g. row after row of pillars). Thomas Auzinger and Bernd Bickel of IST Austria, together with Wolfgang Heidrich of KAUST, however, took an innovative new approach that differs in several key ways. First, they solve the inverse design task: the user enters the color they want to replicate, and then the computer creates a nanostructure pattern that gives that color, rather than attempting to reproduce structures found in nature. Moreover, “our design tool is completely automatic,” says Thomas Auzinger. “No extra effort is required on the part of the user.”

Second, the nanostructures in the template do not follow a particular pattern or have a regular structure; they appear to be randomly composed—a radical break from previous methods, but one with many advantages. “When looking at the template produced by the computer I cannot tell by the structure alone, if I see a pattern for blue or red or green,” explains Auzinger. “But that means the computer is finding solutions that we, as humans, could not. This free-form structure is extremely powerful: it allows for greater flexibility and opens up possibilities for additional coloring effects.” For instance, their design tool can be used to print a square that appears red from one angle, and blue from another (known as directional coloring).

Finally, previous efforts have also stumbled when it came to actual fabrication: the designs were often impossible to print. The new design tool, however, guarantees that the user will end up with a printable template, which makes it extremely useful for the future development of structural coloration in industry. “The design tool can be used to prototype new colors and other tools, as well as to find interesting structures that could be produced industrially,” adds Auzinger. Initial tests of the design tool have already yielded successful results. “It’s amazing to see something composed entirely of clear materials appear colored, simply because of structures invisible to the human eye,” says Bernd Bickel, professor at IST Austria, “we’re eager to experiment with additional materials, to expand the range of effects we can achieve.”

“It’s particularly exciting to witness the growing role of computational tools in fabrication,” concludes Auzinger, “and even more exciting to see the expansion of ‘computer graphics’ to encompass physical as well as virtual images.”

Here’s a link to and a citation for the paper,

Computational Design of Nanostructural Color for Additive Manufacturing by Thomas Auzinger, Wolfgang Heidrich, and Bernd Bickel. ACM Trans. Graph. 37, 4, Article 159 (August 2018). 16 pages. doi.org/10.1145/3197517.3201376

This appears to be open access.

There is also a project page bearing the same title as the paper, Computational Design of Nanostructural Color for Additive Manufacturing.

Nanoparticles in combination could be more toxic

It seems that one set of nanoparticles, e.g., silver nanoparticles, in combination with another material, e.g., cadmium ions, are more dangerous than either one separately according to an August 17, 2018 University of Southern Denmark press release by Birgitte Svennevig (also on EurekAlert but dated August 20, 2018),

Researchers warn that a combination of nanoparticles and contaminants may form a cocktail that is harmful to our cells. In their study, 72 pct. of cells died after exposure to a cocktail of nano-silver and cadmium ions.

Nanoparticles are becoming increasingly widespread in our environment. Thousands of products contain nanoparticles because of their unique properties. Silver nanoparticles are one example: They have an effective antibacterial effect and can be found in refrigerators, sports clothes, cosmetics, tooth brushes, water filters, etc.

There is a significant difference between how the cells react when exposed to nanosilver alone and when they are exposed to a cocktail of nanosilver and cadmium ions. Cadmium ions are naturally found everywhere around us on Earth.

In the study, 72 pct. of the cells died, when exposed to both nanosilver and cadmiun ions. When exposed to nanosilver only, 25 pct. died. When exposed to cadmium ions only, 12 pct. died.

The study was conducted on human liver cancer cells.

  • This study indicates, that we should not look at nanoparticles isolated when we investigate and discuss the effects, they may have on our health. We need to take cocktail effects into account, said Professor Frank Kjeldsen, Dept of Biochemistry and Molecular Biology, SDU, adding:
  • Products with nano particles are being developed and manufactured every day, but in most countries there are no regulations, so there is no way of knowing what and how many nanoparticles are being released into the environment. In my opinion, this should be stopped.

Other studies, led by Professor Kjeldsen have previously shown that human cells interact with metal nanoparticles.

One study showed that nano-silver leads to the formation free radicals in cells and changes in the form and amount of proteins. Many serious diseases are characterized by an overproduction of free radicals in cells. This applies to cancer and neurological diseases such as Alzheimer’s and Parkinson’s.

This is not great news but there are a few things to note about this research. First, it was conducted on cells and therefore not subject to some of the defensive systems found in complete biological organisms such as a mouse or a dandelion plant for example.

Also, since they were cancer cells one might suspect their reactions might differ from those of healthy cells. As for how the cells were exposed to the contaminants, I think (???) they were sitting in a solution of contaminants and most of us do not live in that kind of environment.. Finally, with regard to the concentrations, I have no idea if they are greater than one might expect to encounter in one’s lifecycle but it’s always worth questioning just how much exposure you might expect during yours or a mouse’s or a dandelion’s life.

These caveats aside, Professor Frank Kjeldsen’s work raises some very concerning issues and his work adds to a growing body of evidence.

Here’s a video featuring Dr. Kjeldsen talking about his work,

Here’s a link to and a citation for the paper,

Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells by Renata Rank Miranda, Vladimir Gorshkov, Barbara Korzeniowska, Stefan J. Kempf, Francisco Filipak Neto, & Frank Kjeldsen. Nanotoxicology DOI: https://doi.org/10.1080/17435390.2018.1489987 Published online: 11 Jul 2018

This paper is open access.

It’s a very ‘carbony’ time: graphene jacket, graphene-skinned airplane, and schwarzite

In August 2018, I been stumbled across several stories about graphene-based products and a new form of carbon.

Graphene jacket

The company producing this jacket has as its goal “… creating bionic clothing that is both bulletproof and intelligent.” Well, ‘bionic‘ means biologically-inspired engineering and ‘intelligent‘ usually means there’s some kind of computing capability in the product. This jacket, which is the first step towards the company’s goal, is not bionic, bulletproof, or intelligent. Nonetheless, it represents a very interesting science experiment in which you, the consumer, are part of step two in the company’s R&D (research and development).

Onto Vollebak’s graphene jacket,

Courtesy: Vollebak

From an August 14, 2018 article by Jesus Diaz for Fast Company,

Graphene is the thinnest possible form of graphite, which you can find in your everyday pencil. It’s purely bi-dimensional, a single layer of carbon atoms that has unbelievable properties that have long threatened to revolutionize everything from aerospace engineering to medicine. …

Despite its immense promise, graphene still hasn’t found much use in consumer products, thanks to the fact that it’s hard to manipulate and manufacture in industrial quantities. The process of developing Vollebak’s jacket, according to the company’s cofounders, brothers Steve and Nick Tidball, took years of intensive research, during which the company worked with the same material scientists who built Michael Phelps’ 2008 Olympic Speedo swimsuit (which was famously banned for shattering records at the event).

The jacket is made out of a two-sided material, which the company invented during the extensive R&D process. The graphene side looks gunmetal gray, while the flipside appears matte black. To create it, the scientists turned raw graphite into something called graphene “nanoplatelets,” which are stacks of graphene that were then blended with polyurethane to create a membrane. That, in turn, is bonded to nylon to form the other side of the material, which Vollebak says alters the properties of the nylon itself. “Adding graphene to the nylon fundamentally changes its mechanical and chemical properties–a nylon fabric that couldn’t naturally conduct heat or energy, for instance, now can,” the company claims.

The company says that it’s reversible so you can enjoy graphene’s properties in different ways as the material interacts with either your skin or the world around you. “As physicists at the Max Planck Institute revealed, graphene challenges the fundamental laws of heat conduction, which means your jacket will not only conduct the heat from your body around itself to equalize your skin temperature and increase it, but the jacket can also theoretically store an unlimited amount of heat, which means it can work like a radiator,” Tidball explains.

He means it literally. You can leave the jacket out in the sun, or on another source of warmth, as it absorbs heat. Then, the company explains on its website, “If you then turn it inside out and wear the graphene next to your skin, it acts like a radiator, retaining its heat and spreading it around your body. The effect can be visibly demonstrated by placing your hand on the fabric, taking it away and then shooting the jacket with a thermal imaging camera. The heat of the handprint stays long after the hand has left.”

There’s a lot more to the article although it does feature some hype and I’m not sure I believe Diaz’s claim (August 14, 2018 article) that ‘graphene-based’ hair dye is perfectly safe ( Note: A link has been removed),

Graphene is the thinnest possible form of graphite, which you can find in your everyday pencil. It’s purely bi-dimensional, a single layer of carbon atoms that has unbelievable properties that will one day revolutionize everything from aerospace engineering to medicine. Its diverse uses are seemingly endless: It can stop a bullet if you add enough layers. It can change the color of your hair with no adverse effects. [emphasis mine] It can turn the walls of your home into a giant fire detector. “It’s so strong and so stretchy that the fibers of a spider web coated in graphene could catch a falling plane,” as Vollebak puts it in its marketing materials.

Not unless things have changed greatly since March 2018. My August 2, 2018 posting featured the graphene-based hair dye announcement from March 2018 and a cautionary note from Dr. Andrew Maynard (scroll down ab out 50% of the way for a longer excerpt of Maynard’s comments),

Northwestern University’s press release proudly announced, “Graphene finds new application as nontoxic, anti-static hair dye.” The announcement spawned headlines like “Enough with the toxic hair dyes. We could use graphene instead,” and “’Miracle material’ graphene used to create the ultimate hair dye.”

From these headlines, you might be forgiven for getting the idea that the safety of graphene-based hair dyes is a done deal. Yet having studied the potential health and environmental impacts of engineered nanomaterials for more years than I care to remember, I find such overly optimistic pronouncements worrying – especially when they’re not backed up by clear evidence.

These studies need to be approached with care, as the precise risks of graphene exposure will depend on how the material is used, how exposure occurs and how much of it is encountered. Yet there’s sufficient evidence to suggest that this substance should be used with caution – especially where there’s a high chance of exposure or that it could be released into the environment.

The full text of Dr. Maynard’s comments about graphene hair dyes and risk can be found here.

Bearing in mind  that graphene-based hair dye is an entirely different class of product from the jacket, I wouldn’t necessarily dismiss risks; I would like to know what kind of risk assessment and safety testing has been done. Due to their understandable enthusiasm, the brothers Tidball have focused all their marketing on the benefits and the opportunity for the consumer to test their product (from graphene jacket product webpage),

While it’s completely invisible and only a single atom thick, graphene is the lightest, strongest, most conductive material ever discovered, and has the same potential to change life on Earth as stone, bronze and iron once did. But it remains difficult to work with, extremely expensive to produce at scale, and lives mostly in pioneering research labs. So following in the footsteps of the scientists who discovered it through their own highly speculative experiments, we’re releasing graphene-coated jackets into the world as experimental prototypes. Our aim is to open up our R&D and accelerate discovery by getting graphene out of the lab and into the field so that we can harness the collective power of early adopters as a test group. No-one yet knows the true limits of what graphene can do, so the first edition of the Graphene Jacket is fully reversible with one side coated in graphene and the other side not. If you’d like to take part in the next stage of this supermaterial’s history, the experiment is now open. You can now buy it, test it and tell us about it. [emphasis mine]

How maverick experiments won the Nobel Prize

While graphene’s existence was first theorised in the 1940s, it wasn’t until 2004 that two maverick scientists, Andre Geim and Konstantin Novoselov, were able to isolate and test it. Through highly speculative and unfunded experimentation known as their ‘Friday night experiments,’ they peeled layer after layer off a shaving of graphite using Scotch tape until they produced a sample of graphene just one atom thick. After similarly leftfield thinking won Geim the 2000 Ig Nobel prize for levitating frogs using magnets, the pair won the Nobel prize in 2010 for the isolation of graphene.

Should you be interested, in beta-testing the jacket, it will cost you $695 (presumably USD); order here. One last thing, Vollebak is based in the UK.

Graphene skinned plane

An August 14, 2018 news item (also published as an August 1, 2018 Haydale press release) by Sue Keighley on Azonano heralds a new technology for airplans,

Haydale, (AIM: HAYD), the global advanced materials group, notes the announcement made yesterday from the University of Central Lancashire (UCLAN) about the recent unveiling of the world’s first graphene skinned plane at the internationally renowned Farnborough air show.

The prepreg material, developed by Haydale, has potential value for fuselage and wing surfaces in larger scale aero and space applications especially for the rapidly expanding drone market and, in the longer term, the commercial aerospace sector. By incorporating functionalised nanoparticles into epoxy resins, the electrical conductivity of fibre-reinforced composites has been significantly improved for lightning-strike protection, thereby achieving substantial weight saving and removing some manufacturing complexities.

Before getting to the photo, here’s a definition for pre-preg from its Wikipedia entry (Note: Links have been removed),

Pre-preg is “pre-impregnated” composite fibers where a thermoset polymer matrix material, such as epoxy, or a thermoplastic resin is already present. The fibers often take the form of a weave and the matrix is used to bond them together and to other components during manufacture.

Haydale has supplied graphene enhanced prepreg material for Juno, a three-metre wide graphene-enhanced composite skinned aircraft, that was revealed as part of the ‘Futures Day’ at Farnborough Air Show 2018. [downloaded from https://www.azonano.com/news.aspx?newsID=36298]

A July 31, 2018 University of Central Lancashire (UCLan) press release provides a tiny bit more (pun intended) detail,

The University of Central Lancashire (UCLan) has unveiled the world’s first graphene skinned plane at an internationally renowned air show.

Juno, a three-and-a-half-metre wide graphene skinned aircraft, was revealed on the North West Aerospace Alliance (NWAA) stand as part of the ‘Futures Day’ at Farnborough Air Show 2018.

The University’s aerospace engineering team has worked in partnership with the Sheffield Advanced Manufacturing Research Centre (AMRC), the University of Manchester’s National Graphene Institute (NGI), Haydale Graphene Industries (Haydale) and a range of other businesses to develop the unmanned aerial vehicle (UAV), which also includes graphene batteries and 3D printed parts.

Billy Beggs, UCLan’s Engineering Innovation Manager, said: “The industry reaction to Juno at Farnborough was superb with many positive comments about the work we’re doing. Having Juno at one the world’s biggest air shows demonstrates the great strides we’re making in leading a programme to accelerate the uptake of graphene and other nano-materials into industry.

“The programme supports the objectives of the UK Industrial Strategy and the University’s Engineering Innovation Centre (EIC) to increase industry relevant research and applications linked to key local specialisms. Given that Lancashire represents the fourth largest aerospace cluster in the world, there is perhaps no better place to be developing next generation technologies for the UK aerospace industry.”

Previous graphene developments at UCLan have included the world’s first flight of a graphene skinned wing and the launch of a specially designed graphene-enhanced capsule into near space using high altitude balloons.

UCLan engineering students have been involved in the hands-on project, helping build Juno on the Preston Campus.

Haydale supplied much of the material and all the graphene used in the aircraft. Ray Gibbs, Chief Executive Officer, said: “We are delighted to be part of the project team. Juno has highlighted the capability and benefit of using graphene to meet key issues faced by the market, such as reducing weight to increase range and payload, defeating lightning strike and protecting aircraft skins against ice build-up.”

David Bailey Chief Executive of the North West Aerospace Alliance added: “The North West aerospace cluster contributes over £7 billion to the UK economy, accounting for one quarter of the UK aerospace turnover. It is essential that the sector continues to develop next generation technologies so that it can help the UK retain its competitive advantage. It has been a pleasure to support the Engineering Innovation Centre team at the University in developing the world’s first full graphene skinned aircraft.”

The Juno project team represents the latest phase in a long-term strategic partnership between the University and a range of organisations. The partnership is expected to go from strength to strength following the opening of the £32m EIC facility in February 2019.

The next step is to fly Juno and conduct further tests over the next two months.

Next item, a new carbon material.

Schwarzite

I love watching this gif of a schwarzite,

The three-dimensional cage structure of a schwarzite that was formed inside the pores of a zeolite. (Graphics by Yongjin Lee and Efrem Braun)

An August 13, 2018 news item on Nanowerk announces the new carbon structure,

The discovery of buckyballs [also known as fullerenes, C60, or buckminsterfullerenes] surprised and delighted chemists in the 1980s, nanotubes jazzed physicists in the 1990s, and graphene charged up materials scientists in the 2000s, but one nanoscale carbon structure – a negatively curved surface called a schwarzite – has eluded everyone. Until now.

University of California, Berkeley [UC Berkeley], chemists have proved that three carbon structures recently created by scientists in South Korea and Japan are in fact the long-sought schwarzites, which researchers predict will have unique electrical and storage properties like those now being discovered in buckminsterfullerenes (buckyballs or fullerenes for short), nanotubes and graphene.

An August 13, 2018 UC Berkeley news release by Robert Sanders, which originated the news item, describes how the Berkeley scientists and the members of their international  collaboration from Germany, Switzerland, Russia, and Italy, have contributed to the current state of schwarzite research,

The new structures were built inside the pores of zeolites, crystalline forms of silicon dioxide – sand – more commonly used as water softeners in laundry detergents and to catalytically crack petroleum into gasoline. Called zeolite-templated carbons (ZTC), the structures were being investigated for possible interesting properties, though the creators were unaware of their identity as schwarzites, which theoretical chemists have worked on for decades.

Based on this theoretical work, chemists predict that schwarzites will have unique electronic, magnetic and optical properties that would make them useful as supercapacitors, battery electrodes and catalysts, and with large internal spaces ideal for gas storage and separation.

UC Berkeley postdoctoral fellow Efrem Braun and his colleagues identified these ZTC materials as schwarzites based of their negative curvature, and developed a way to predict which zeolites can be used to make schwarzites and which can’t.

“We now have the recipe for how to make these structures, which is important because, if we can make them, we can explore their behavior, which we are working hard to do now,” said Berend Smit, an adjunct professor of chemical and biomolecular engineering at UC Berkeley and an expert on porous materials such as zeolites and metal-organic frameworks.

Smit, the paper’s corresponding author, Braun and their colleagues in Switzerland, China, Germany, Italy and Russia will report their discovery this week in the journal Proceedings of the National Academy of Sciences. Smit is also a faculty scientist at Lawrence Berkeley National Laboratory.

Playing with carbon

Diamond and graphite are well-known three-dimensional crystalline arrangements of pure carbon, but carbon atoms can also form two-dimensional “crystals” — hexagonal arrangements patterned like chicken wire. Graphene is one such arrangement: a flat sheet of carbon atoms that is not only the strongest material on Earth, but also has a high electrical conductivity that makes it a promising component of electronic devices.

schwarzite carbon cage

The cage structure of a schwarzite that was formed inside the pores of a zeolite. The zeolite is subsequently dissolved to release the new material. (Graphics by Yongjin Lee and Efrem Braun)

Graphene sheets can be wadded up to form soccer ball-shaped fullerenes – spherical carbon cages that can store molecules and are being used today to deliver drugs and genes into the body. Rolling graphene into a cylinder yields fullerenes called nanotubes, which are being explored today as highly conductive wires in electronics and storage vessels for gases like hydrogen and carbon dioxide. All of these are submicroscopic, 10,000 times smaller than the width of a human hair.

To date, however, only positively curved fullerenes and graphene, which has zero curvature, have been synthesized, feats rewarded by Nobel Prizes in 1996 and 2010, respectively.

In the 1880s, German physicist Hermann Schwarz investigated negatively curved structures that resemble soap-bubble surfaces, and when theoretical work on carbon cage molecules ramped up in the 1990s, Schwarz’s name became attached to the hypothetical negatively curved carbon sheets.

“The experimental validation of schwarzites thus completes the triumvirate of possible curvatures to graphene; positively curved, flat, and now negatively curved,” Braun added.

Minimize me

Like soap bubbles on wire frames, schwarzites are topologically minimal surfaces. When made inside a zeolite, a vapor of carbon-containing molecules is injected, allowing the carbon to assemble into a two-dimensional graphene-like sheet lining the walls of the pores in the zeolite. The surface is stretched tautly to minimize its area, which makes all the surfaces curve negatively, like a saddle. The zeolite is then dissolved, leaving behind the schwarzite.

soap bubble schwarzite structure

A computer-rendered negatively curved soap bubble that exhibits the geometry of a carbon schwarzite. (Felix Knöppel image)

“These negatively-curved carbons have been very hard to synthesize on their own, but it turns out that you can grow the carbon film catalytically at the surface of a zeolite,” Braun said. “But the schwarzites synthesized to date have been made by choosing zeolite templates through trial and error. We provide very simple instructions you can follow to rationally make schwarzites and we show that, by choosing the right zeolite, you can tune schwarzites to optimize the properties you want.”

Researchers should be able to pack unusually large amounts of electrical charge into schwarzites, which would make them better capacitors than conventional ones used today in electronics. Their large interior volume would also allow storage of atoms and molecules, which is also being explored with fullerenes and nanotubes. And their large surface area, equivalent to the surface areas of the zeolites they’re grown in, could make them as versatile as zeolites for catalyzing reactions in the petroleum and natural gas industries.

Braun modeled ZTC structures computationally using the known structures of zeolites, and worked with topological mathematician Senja Barthel of the École Polytechnique Fédérale de Lausanne in Sion, Switzerland, to determine which of the minimal surfaces the structures resembled.

The team determined that, of the approximately 200 zeolites created to date, only 15 can be used as a template to make schwarzites, and only three of them have been used to date to produce schwarzite ZTCs. Over a million zeolite structures have been predicted, however, so there could be many more possible schwarzite carbon structures made using the zeolite-templating method.

Other co-authors of the paper are Yongjin Lee, Seyed Mohamad Moosavi and Barthel of the École Polytechnique Fédérale de Lausanne, Rocio Mercado of UC Berkeley, Igor Baburin of the Technische Universität Dresden in Germany and Davide Proserpio of the Università degli Studi di Milano in Italy and Samara State Technical University in Russia.

Here’s a link to and a citation for the paper,

Generating carbon schwarzites via zeolite-templating by Efrem Braun, Yongjin Lee, Seyed Mohamad Moosavi, Senja Barthel, Rocio Mercado, Igor A. Baburin, Davide M. Proserpio, and Berend Smit. PNAS August 14, 2018. 201805062; published ahead of print August 14, 2018. https://doi.org/10.1073/pnas.1805062115

This paper appears to be open access.

Bristly hybrid materials

Caption: [Image 1] A carbon fiber covered with a spiky forest of NiCoHC nanowires. Credit: All images reproduced from reference 1 under a Creative Commons Attribution 4.0 International License© 2018 KAUST

It makes me think of small, cuddly things like cats and dogs but it’s not. From an August 7, 2018 King Abdullah University of Science and Technology (KAUST; Saudi Arabia) news release (also published on August 12, 2018 on EurekAlert),

By combining multiple nanomaterials into a single structure, scientists can create hybrid materials that incorporate the best properties of each component and outperform any single substance. A controlled method for making triple-layered hollow nanostructures has now been developed at KAUST. The hybrid structures consist of a conductive organic core sandwiched between layers of electrocatalytically active metals: their potential uses range from better battery electrodes to renewable fuel production.

Although several methods exist to create two-layer materials, making three-layered structures has proven much more difficult, says Peng Wang from the Water Desalination and Reuse Center who co-led the current research with Professor Yu Han, member of the Advanced Membranes and Porous Materials Center at KAUST. The researchers developed a new, dual-template approach, explains Sifei Zhuo, a postdoctoral member of Wang’s team.

The researchers grew their hybrid nanomaterial directly on carbon paper–a mat of electrically conductive carbon fibers. They first produced a bristling forest of nickel cobalt hydroxyl carbonate (NiCoHC) nanowires onto the surface of each carbon fiber (image 1). Each tiny inorganic bristle was coated with an organic layer called hydrogen substituted graphdiyne (HsGDY) (image 2 [not included here]).

Next was the key dual-template step. When the team added a chemical mixture that reacts with the inner NiCoHC, the HsGDY acted as a partial barrier. Some nickel and cobalt ions from the inner layer diffused outward, where they reacted with thiomolybdate from the surrounding solution to form the outer nickel-, cobalt-co-doped MoS2 (Ni,Co-MoS2) layer. Meanwhile, some sulfur ions from the added chemicals diffused inwards to react with the remaining nickel and cobalt. The resulting substance (image 3 [not included here]) had the structure Co9S8, Ni3S2@HsGDY@Ni,Co-MoS2, in which the conductive organic HsGDY layer is sandwiched between two inorganic layers (image 4 [not included here]).

The triple layer material showed good performance at electrocatalytically breaking up water molecules to generate hydrogen, a potential renewable fuel. The researchers also created other triple-layer materials using the dual-template approach

“These triple-layered nanostructures hold great potential in energy conversion and storage,” says Zhuo. “We believe it could be extended to serve as a promising electrode in many electrochemical applications, such as in supercapacitors and sodium-/lithium-ion batteries, and for use in water desalination.”

Here’s a link to and a citation for the paper,

Dual-template engineering of triple-layered nanoarray electrode of metal chalcogenides sandwiched with hydrogen-substituted graphdiyne by Sifei Zhuo, Yusuf Shi, Lingmei Liu, Renyuan Li, Le Shi, Dalaver H. Anjum, Yu Han, & Peng Wang. Nature Communicationsvolume 9, Article number: 3132 (2018) DOI: https://doi.org/10.1038/s41467-018-05474-0 Published 07 August 2018

This paper is open access.

 

Build nanoparticles using techniques from the ancient Egyptians

Great Pyramid of Giza and Sphinx [downloaded from http://news.ifmo.ru/en/science/photonics/news/7731/]

Russian and German scientists have taken a closer look at the Great Pyramid as they investigate better ways of designing sensors and solar cells. From a July 30, 2018 news item on Nanowerk,

An international research group applied methods of theoretical physics to investigate the electromagnetic response of the Great Pyramid to radio waves. Scientists predicted that under resonance conditions the pyramid can concentrate electromagnetic energy in its internal chambers and under the base. The research group plans to use these theoretical results to design nanoparticles capable of reproducing similar effects in the optical range. Such nanoparticles may be used, for example, to develop sensors and highly efficient solar cells.

A July 30, 2018 ITMO University press release, which originated the news item,  expands on the theme,

While Egyptian pyramids are surrounded by many myths and legends, we have little scientifically reliable information about their physical properties. As it turns out, sometimes this information proves to be more fascinating than any fiction. This idea found confirmation in a new joint study undertaken by scientists from ITMO University and the Laser Zentrum Hannover. The physicists took an interest in how the Great Pyramid would interact with electromagnetic waves of a proportional, or resonant, length. Calculations showed that in the resonant state the pyramid can concentrate electromagnetic energy in its internal chambers as well as under its base, where the third unfinished chamber is located.

These conclusions were derived on the basis of numerical modeling and analytical methods of physics. The researchers first estimated that resonances in the pyramid can be induced by radio waves with a length ranging from 200 to 600 meters. Then they made a model of the electromagnetic response of the pyramid and calculated the extinction cross section. This value helps to estimate which part of the incident wave energy can be scattered or absorbed by the pyramid under resonant conditions. Finally, for the same conditions, the scientists obtained the electromagnetic fields distribution inside the pyramid.

3D model of the pyramid. Credit: cheops.SU
3D model of the pyramid. Credit: cheops.SU

In order to explain the results, the scientists conducted a multipole analysis. This method is widely used in physics to study the interaction between a complex object and electromagnetic field. The object scattering the field is replaced by a set of simpler sources of radiation: multipoles. The collection of multipoles radiation coincides with the field scattering by an entire object. Therefore, by knowing the type of each multipole, it is possible to predict and explain the distribution and configuration of the scattered fields in the whole system.

The Great Pyramid attracted the researchers’ attention while they were studying the interaction between light and dielectric nanoparticles. The scattering of light by nanoparticles depends on their size, shape, and refractive index of the source material. By varying these parameters, it is possible to determine the resonance scattering regimes and use them to develop devices for controlling light at the nanoscale.

“Egyptian pyramids have always attracted great attention. We as scientists were interested in them as well, and so we decided to look at the Great Pyramid as a particle resonantly dissipating radio waves. Due to the lack of information about the physical properties of the pyramid, we had to make some assumptions. For example, we assumed that there are no unknown cavities inside, and the building material has the properties of an ordinary limestone and is evenly distributed in and out of the pyramid. With these assumptions, we obtained interesting results that can have important practical applications,” says Andrey Evlyukhin, DSc, scientific supervisor and coordinator of the research.

Now the scientists plan to use the results to reproduce similar effects at the nanoscale.

Polina Kapitanova
Polina Kapitanova

“By choosing a material with suitable electromagnetic properties, we can obtain pyramidal nanoparticles with a potential for practical application in nanosensors and effective solar cells,” says Polina Kapitanova, PhD, associate at the Faculty of Physics and Engineering of ITMO University.

The research was supported by the Russian Science Foundation and the Deutsche Forschungsgemeinschaft (grants № 17-79-20379 and №16-12-10287).

Here’s a link to and a citation for the paper,

Electromagnetic properties of the Great Pyramid: First multipole resonances and energy concentration featured by Mikhail Balezin, Kseniia V. Baryshnikova, Polina Kapitanova, and Andrey B. Evlyukhin. Journal of Applied Physics 124, 034903 (2018) https://doi.org/10.1063/1.5026556 or Journal of Applied Physics, Volume 124, Issue 3. 10.1063/1.5026556 Published Online 20 July 2018

This paper is behind a paywall..

Observing individual silver nanoparticles in real time

A new technique for better understanding how silver nanoparticles might affect the environment was announced in a July 30, 2018 news item on ScienceDaily,

Chemists at Ruhr-Universität Bochum have developed a new method of observing the chemical reactions of individual silver nanoparticles, which only measure a thousandth of the thickness of a human hair, in real time. The particles are used in medicine, food and sports items because they have an antibacterial and anti-inflammatory effect. However, how they react and degrade in ecological and biological systems is so far barely understood. The team in the Research Group for Electrochemistry and Nanoscale Materials showed that the nanoparticles transform into poorly soluble silver chloride particles under certain conditions. The group led by Prof Dr Kristina Tschulik reports on the results in the Journal of the American Chemical Society from July 11, 2018.

A July 30,2018 Ruhr-University Bochum (RUB) press release (also on EurekAlert) by Julia Weiler, which originated the news item, provides more information,

Even under well-defined laboratory conditions, current research has yielded different, sometimes contradictory, results on the reaction of silver nanoparticles. “In every batch of nanoparticles, the individual properties of the particles, such as size and shape, vary,” says Kristina Tschulik, a member of the Cluster of Excellence Ruhr Explores Solvation. “With previous procedures, a myriad of particles was generally investigated at the same time, meaning that the effects of these variations could not be recorded. Or the measurements took place in a high vacuum, not under natural conditions in an aqueous solution.”

The team led by Kristina Tschulik thus developed a method that enables individual silver particles to be investigated in a natural environment. “Our aim is to be able to record the reactivity of individual particles,” explains the researcher. This requires a combination of electrochemical and spectroscopic methods. With optical and hyperspectral dark-field microscopy, the group was able to observe individual nanoparticles as visible and coloured pixels. Using the change in the colour of the pixels, or more precisely their spectral information, the researchers were able to follow what was happening in an electrochemical experiment in real time.

Degradation of the particles slowed down

In the experiment, the team replicated the oxidation of silver in the presence of chloride ions, which often takes place in ecological and biological systems. “Until now, it was generally assumed that the silver particles dissolve in the form of silver ions,” describes Kristina Tschulik. However, poorly soluble silver chloride was formed in the experiment – even if only a few chloride ions were present in the solution.

“This extends the lifespan of the nanoparticles to an extreme extent and their breakdown is slowed down in an unexpectedly drastic manner,” summarises Tschulik. “This is equally important for bodies of water and for living beings because this mechanism could cause the heavy metal silver to accumulate locally, which can be toxic for many organisms.”

Further development planned

The Bochum-based group now wants to further improve its technology for analysing individual nanoparticles in order to better understand the ageing mechanisms of such particles. The researchers thus want to obtain more information about the biocompatibility of the silver particles and the lifespan and ageing of catalytically active nanoparticles in the future.

Here’s a link to and a citation for the paper,

Simultaneous Opto- and Spectro-Electrochemistry: Reactions of Individual Nanoparticles Uncovered by Dark-Field Microscopy by Kevin Wonner, Mathies V. Evers, and Kristina Tschulik. J. Am. Chem. Soc., Article ASAP DOI: 10.1021/jacs.8b02367 Publication Date (Web): July 11, 2018

Copyright © 2018 American Chemical Society

This paper is behind a paywall.