Archive for the ‘interviews’ Category

Industry Canada, Vanessa Clive, nanotechnology, and assessing economic impacts

Monday, July 23rd, 2012

I have long (one year) wanted to feature an interview with Vanessa Clive, Nanotechnology Policy Advisor; Industry Sector, at Industry Canada but have been distracted from sending interview questions until about several weeks ago.  (Sometimes, I lose track to time.)

Here then are the interview questions  I asked and the answers Vanessa very kindly provided,

1.      Could you describe your role? 

Industry Canada’s mandate is to help make Canadian industry more productive and competitive in the global economy, thus improving the economic and social well-being of Canadians.  As an emerging/nascent technology, nanotechnology can help contribute towards this objective.  Our role vis a vis nanotechology is to:

  • better understand Canadian capabilities, strengths and expertise
  • contribute to effective policy development
  • contribute to the development of a supportive business environment for innovation and commercialization

2.       Recently, you helped organize an event in Washington, DC (International Symposium on Assessing the Economic Impact of Nanotechnology, March 27-28, 2012). Could you give a brief overview of why this was needed, who attended, & what happened? 

The Symposium was organized jointly by the OECD Working Party on Nanotechnology (WPN) and the National Nanotechnology Coordinating Office for the U.S. National Nanotechnology Initiative (NNI), and hosted by the American Association for the Advancement of Science (AAAS). I was a member of the OECD WPN Steering Committee which worked with the NNI to organize the event.

Some 200 people participated from OECD and non-OECD countries, representing a broad spectrum of sectors, industries, and areas of expertise. In addition to plenary sessions, industry break-out discussions were organized on advanced materials, food packaging, transportation, nanomedicine, energy, and electronics.

The decision to hold the event recognized the important potential contribution of nanotechnology to innovation, as reflected in rising R&D investments over the past decade. OECD member countries wish to explore ways to assess returns to these investments and the broader economic impacts of nanotechnology more generally, as well as the challenges for effective innovation policy development in this area.

The agenda and presentations can be viewed at http://nano.gov/node/729. Four background papers on related topics were also commissioned for the Symposium and can be found at the same site.

3.      What can be said about nanotechnology’s economic impacts and what information (e.g. bibliometric measures, no. of patents, etc.) is being used to arrive at that conclusion? 

Given the still relatively early stage of developments, the range of potential applications, and other factors, there are major challenges to estimating potential impacts. Holding this Symposium was intended to provide a start to develop useful indicators and other assessment tools.

4.      So, how is Canada doing relative to the international scene?

As discussed above, given the lack of measures, it is difficult to assess our relative position. However, Canadian federal and provincial governments have invested increasing amounts in nanotechnology R&D over the past decade or so. These investments have supported an array of government funding programs and contributed to the establishment of a world-class R&D infrastructure and research community and a growing number of companies involved in nanotechnology across industry sectors in Canada.

5.      Is there anything that stands out from the symposium?

It was clear from the level of attendance, presentations, and discussions which took place, that there is widespread interest in the symposium topics. To learn more about the event, I would encourage interested people to visit the website where presentations and background papers are posted – http://nano.gov/node/729.

6.      Are there any Industry Canada plans in the works for developing new assessment tools given that, unlike many countries, Canada does not have a national nanotechnology funding hub? 

We are working with the OECD to develop useful tools that would enable us to estimate or measure the economic impacts of nanotechnology.

7.      Are there any plans for a nanotechnology ‘road map’ similar to the digital media road map? Or perhaps there’s something else in the works?

Industry Canada is focused on assisting Canadian industry to grow, compete in the global economy, and create jobs. In order to do so we are building the department’s knowledge base about Canadian activities and capabilities, contributing to sound policy development in domestic and international for a, and contributing to building a supportive business environment for responsible innovation and commercialization in this field.

Thank you for the insight into the Canadian nanotechnology situation and the issues around economic impacts as per Industry Canada and tor taking the time to do this . Also, I am very happy to see the link to the presentations and background papers for the March 2012 nanotechnology and economic impacts event in Washington, DC (first mentioned in my Jan. 27, 2012 posting).

I did briefly visit the website which is a US National Nanotechnology Initiative website. The event page for which Vanessa provided a link hosts the background papers and links to other pages hosting the presentations and the agenda providing a rich resource for anyone interested in the issue of nanotechnology and its possible economic impacts.

Science tattoos and a brief chat with Carl Zimmer about his book, Science Ink

Friday, January 13th, 2012

I’m back with another New York Academy of Sciences public event (my Jan. 3, 2012 posting listed a number of events), this time it’s  Science Ink: Tattoos of the Science Obsessed with Carl Zimmer. Here’s a description of the event (which will take place on Tuesday, Jan. 24, 2012 from 7 – 8:30 pm),

How much do you love science? Enough to get it permanently inked on your skin?

Join award-winning science journalist and New York Academy of Sciences regular Carl Zimmer for a talk on his latest book, Science Ink, which showcases over 300 tattoos dedicated to the pursuit of science.

Tattoos have been a part of human culture as far back as Neolithic times. Scientists have uncovered tattoos on mummified ancients from Western China to Egypt to Scandanavia. And the subjects of those tattoos vary as much as the cultures—from elaborate animal and organic designs to simple graphic designs thought to have therapeutic qualities. In more modern times in the Western world, tattoos came into vogue in the late 1800s when British elites began to tattoo themselves—both Winston Churchill and his mother, Lady Randolph Churchill, had tattoos. And today, it’s clear that in American culture, tattoos have had a resurgence in popularity.

Choosing what to mark your body with permanently is a source of much conversation and consternation. And as Carl Zimmer discovered after a blog post asking about science tattoos, there is a passionate group of people who made the choice to ink themselves with science.

In this special event, Zimmer will speak about the science and history of tattooing, and offer highlights from his book Science Ink, which features a gallery of scientific tattoos, spanning fields from evolutionary biology and neuroscience to mathematics and astrophysics. In addition, Zimmer is inviting a handful of those featured in the book to come and share the compelling personal stories behind their ink.

Here are more details about the event, pricing is as follows,

Member:                                                                   $15

Student / Postdoc / Fellow Member:           $10

Nonmember:                                                           $25

Student / Postdoc / Fellow Nonmember:   $20

In a Jan. 9, 2012 posting on his blog, The Loom, Carl Zimmer offers more information about his book and upcoming talk plus a discount,

Get $10 dollars off admission by using the promo code ZIMMER. Register [here or http://www.nyas.org/scienceink]

The address and contact details:

The New York Academy of Sciences

7 World Trade Center
250 Greenwich Street, 40th floor
New York, NY 10007-2157
212.298.8600
nyas@nyas.org

As for Carl Zimmer and science tattoos, I decided to investigate a bit further. Here’s an excerpt from Carl Zimmer’s website bio webpage,

The New York Times Book Review calls Carl Zimmer “as fine a science essayist as we have.” In his books, essays, articles, and blog posts, Zimmer reports from the frontiers of biology, where scientists are expanding our understanding of life. He is a popular speaker at universities, medical schools, museums, and festivals, and he is also a frequent guest on radio programs such as Radio Lab and This American Life.

In addition to writing books, Zimmer has written hundreds of articles for the New York Times and magazines including National Geographic, Time, Scientific American, Science, and Popular Science. From 1994 to 1998 Zimmer was a senior editor at Discover, where he remains a contributing editor and writes a monthly column about the brain.

Since 2003, Zimmer has written the award-winning blog, The Loom. Along with essays about science, The Loom is also home to a popular gallery of science tattoos. In November 2011, Zimmer will publish a book of his favorite selections, called Science Ink: Tales of the Science Obsessed.

Zimmer is a lecturer at Yale University, where he teaches writing about science and the environment. He was also the first Visiting Scholar at the Science, Health, and Environment Reporting Program at New York University’s Arthur L. Carter Journalism Institute.

He is, to his knowledge, the only writer after whom a species of tapeworm has been named. [emphasis mine]

I do love a sense of humour. As for Zimmer’s latest book, Science Ink, his website offers some excerpts from it (here are a few samples),

Astrarium, p.71
“Although I’m not a scientist by trade,” writes Lauren Caldwell, “my work on seventeenth- and eighteenth-century British literature has provided ample opportunity for me to become acquainted with the work of some brilliant scientific innovators. Though we have discarded some of their ideas, their work retains all of its vital visual force. ¶ “Years ago I discovered and fell in love with the comprehensive diagrams in Giovanni de’Dondi’s 1364 Il Tractatus Astarii, which contained the plans for the first famous astrarium. Each piece has its own delicate mechanical beauty, but I chose for my backpiece the Mercury wheelwork. Of course, you couldn’t track Mercury with it—de’Dondi followed Ptolemy—but his astrarium remains a lovely and impressive testament to human ingenuity and curiosity. ¶ “The more spare geometrical diagrams that surround the de’Dondi piece are taken from Sir Isaac Newton’s Principia Mathematica—of which little enough, I imagine, need be said. Though in many respects these two men couldn’t have been more different, they shared a vision of a universe as elegant and aesthetically compelling today as it was when they lived and worked.”

Astrarium tattoo (from Science Ink by Carl Zimmer)

DNA monster, bottom p.102
Jay Phelan, a biologist at UCLA, got his DNA tattoo in 1990 while he was in graduate school. “As I got deeper into the study of evolution, genetics, and human behavior,” he writes, “I realized that there was a tension between what my genes ‘wanted’ me to do and what I wanted to do, from the fattiness of the foods I ate, to the selfishness/selflessness I showed to others, to issues with managing my money, my risk-taking, and my relationships, and more. It dawned on me that I was fighting a never-ending battle. Anyway, I tried to come up with a design that captured that tension and, once I did, decided to get it tattooed on my back.”

DNA monster tattoo (from Science Ink by Carl Zimmer)

I was sufficiently fascinated to send off a few questions to Carl Zimmer about science tattoos and his upcoming talk at the NYAS and he very kindly replied,

  • Given the title of your latest book (Science Ink: Tattoos of the Science Obsessed), I’m wondering if you have any tattoos.
    If so, what is it?

I don’t have any tattoos actually. I’ve never been particularly interested in getting one, and am no big fan of needles. But I find the lack of a tattoo is no impediment to appreciating the tattoos of scientists.  If I sell of whole bunch of copies of the book, maybe I’ll have to celebrate by getting one. I was thinking about getting  my wife’s name, Grace, spelled out as amino acids.

  • What most surprised you about this book?

At first the surprise was simply that any scientist at all had tattoos.  The initial flood of pictures that filled up my e-mail inbox was amazing. After I got accustomed to the idea that there is lots and lots of scientists with tattoos out there, the next big surprise was how many interesting stories there were, illustrated by these tattoos. Stories from the history of science, stories from the personal lives of the scientists. And since telling stories is my job, I decided to turn Science Ink into a book of miniature essays.

  • Is there any branch of science that attracts more people who are willing to ink their bodies?

I don’t see any field being way in the lead compared other ones. In fact, what really impressed me was that just about every branch of science I can imagine ended up being represented in the book. I have groups of linguistics tattoos in the book, astronomy tattoo,s medical tattoos ,tattoos about quantum physics, and so on. Basically, by looking at these tattoos you end up taking a tour of all science.

  • Could you briefly preview a little bit of your Ja.24.12 talk?

I’m going to be talking at the New York Academy of Sciences about what got me into this peculiar project, and some of the things I learned about scientists and science in the process. But I’m also going to be talking about tattooing itself. It’s actually a pretty fascinating scientific subject in its own right. Anthropologists have found evidence of tattooing in many cultures around the world, and it goes back thousands of years. So I think that tattoos speak to something really important about what it means to be human–and, in this particular case, what it means to be a scientist.

Dear Carl, Thank you for taking time out of a very busy schedule (he has a talk scheduled Jan. 20, 2012 too; scroll down to the next paragraph for information about that event plus all of his usual work) to respond. I hope the book is a huge success.

There is one other related Science Ink event that might be of interest. The ScienceOnline2012 conference, January 19 – 21, 2012 (no spaces left for attendees), held annually in Durham, North Carolina and (mentioned in my Nov. 2, 2011 posting) is hosting a Science of Ink tour for 30 people to the Dogstar Tattoo Company on Friday, Jan. 20, 2012. The webpage for the tour notes that it is completely booked but if you follow the Twitter hash tag (#SciInk) you may be able to get on the tour (as people do drop out of these things for one reason or another). From the tour webpage,

Join us on Friday afternoon, January 20th, at the Dogstar Tattoo Company in Durham, NC’s Golden Belt district for a lecture by Carl Zimmer on the science of tattoos, a reception & tour of the studio, and the opportunity to get inked (or just watch the process!). Carl will have his book, Science Ink: The Tattoos of the Science Obsessed available–and we can probably convince him to sign a few ☺

This isn’t your typical tattoo shop. When Carl Zimmer first saw the photos, he declared, “It’s like a cathedral of tattoo parlors.”

When you register, please indicate if you definitely plan to get a tattoo, might want to get a tattoo, or definitely don’t plan to get inked (but want to observe). [emphasis mine]

Good luck with getting on the tour or getting to the talk in New York. As for anyone from Vancouver who might be hoping that Carl Zimmer will be here for the American Association for the Advancement of Science (AAAS) 2012 annual meeting, sadly, the answer is no.

Science culture panel and Denise Amyot at the 2011 Canadian Science Policy Conference

Tuesday, November 15th, 2011

The 2011 Canadian Science Policy Conference (CSPC) starts tomorrow, Nov. 16, 2011 and runs until Nov. 18, 2011. Denise Amyot, speaker on the 2011 CSPC Science Culture, Organized and Prioritized: Three National and International Initiatives panel and President and Chief Executive Officer of the Canada Science and Technology Museums Corporation, has very kindly given me an interview.

Here’s a little bit about Denise Amyot first (from the bio on the 2011 CSPC conference website),

Denise Amyot is currently, President and CEO of the Canada Science and Technology Museums Corporation whose mandate is to foster scientific and technological literacy throughout the country. The Corporation and its three museums – the Canada Agriculture Museum, the Canada Aviation and Space Museum, and the Canada Science and Technology Museum – tell the stories of Canadian ingenuity and achievement in science and technology.

She has worked both in National Headquarters and in regions in several federal departments including central agencies, Human Resources and Skills Development Canada, National Defense, Natural Resources Canada, and Canadian Heritage. In her former three roles as Assistant Deputy Minister, she was respectively responsible for leading and managing leadership development programs and developing policies for employees and executives throughout the public Service of Canada, the corporate management services, as well as public affairs and ministerial services. She has worked extensively in policy and line operations in the context of programs and service delivery, in social, economic, and cultural areas. She also worked for few years with the Government of the Northwest Territories.

Ms Amyot is the former President of the Institute of Public Administration of Canada, Vice-President of the Head of Federal Agencies Steering Committee, and member of the Board of Governors at the Ottawa University and at the Algonquin College. She is the former President of the Association of Professional Executives of the Public Service of Canada and former President of the Communications Community Office.

Ms Amyot has obtained a Master’s degree in Education and three Bachelor degrees in Biology, in Arts and in Education.

Now, here are the questions and answers:

The panel (Science Culture, Organized and Prioritized: Three National and International Initiatives) features you from the Canada Science and Technology Museums Corporation (CSTMC); Lesley Lewis, CEO of the Ontario Science Centre; Ian Chubb, Chief Scientist for Australia and is being moderated by Tracey Ross, ED for the Canadian Association of Science Centres. Could you describe the difference between a museum of science and technology and a science centre?

Science museums are distinctive from science centres as they are the steward of a collection that provides an historical perspective on a specific cross-section of society. Science museums use artifacts from their collection to interpret science and technology within society and help visitor acquire a deeper understanding on its developmental and evolutionary nature. Like science centres, science museums also engage visitors on various aspect of current science and offer experiential, hands on activities.

Could you give a little history of the CSTMC and explain why there are three museums?

The CSTMC was created 21 years ago to govern the Canada Science and Technology Museum and the Canada Aviation and Space Museum. The Canada Agriculture Museum joined the corporation in 1997. Previous to 1990 all national museums were managed through a single corporation which posed challenges considering the diversity of audience, needs and mandates of these institutions.

The three museums share a common vision of engaging all Canadians in appreciating their scientific and technological heritage, and awaken them to our country’s potential of creativity and innovation to solve today’s challenges and propel us in the 21st century.

How do you view science culture in Canada and how would you describe it in relation to the international scene?

There has never been a time in history when science and technology have had greater impact on the lives of our citizens or have been more important to our economic competitiveness, prosperity and societal well being. I understand science culture as the degree in which Canadians understand the basic of science, are able to make daily decisions informed by a basic understanding of science and use of scientific method (inquiry). Science culture is an important vector of economic prosperity. Science culture also informs the degree in which science is considered as a desirable field of study for youth (STEM) leading to fulfilling careers.

Sustaining a strong and vibrant science culture is essential to Canada’s long term economic, environmental and social success in a global world. The world is looking at Canada to develop an economic and societal model that will smartly develop new and innovative ways of sustaining the exploitation of its natural resources while creating an inclusive society that will harness the talent, creativity and potential of every citizen. In the last ten years, jobs in science and technology have seen the largest growth.

Last year an initiative from the CSTMC for an online science network/hub was announced. Can you talk a little about the initiative and what happened to it?

For financial reasons, we have taken a step back in this project and have decided to postpone activities for the time being. Inspiring Australia has put a similar idea forward earlier this year and with significantly more resources than those we had put forward. We are watching this closely, to see how they will go about this and what sort of engagement they will garner.

I see the need for a more active national dialogue on science beyond sharing information about research, or explaining how it will benefit us. We need an open and respectful two-way dialogue between the experts and the citizens, the converted and the agnostics, a dialogue that spans the nation and involves universities, schools, science centres and museums, governments, businesses, community groups, and individuals. To change our collective thinking about science, more efforts will need to be directed to this dialogue. But most importantly, it will require stronger collaborations and coordination between institutions nation-wide. Using emerging digital technologies and social media applications seem to be the way of the future and we remain committed to playing a role in this area.

I assume you’ll be talking about the initiative to benchmark science culture in order to measure future progress. Could you share a little bit about your talk (how do you go about benchmarking science culture; has anyone done it before; how long will it take; does it require government funding; and, if so, how much?) that could serve both as a preview and as some information for those of us who won’t be able to attend?

There is strong agreement that having a strong and vibrant science culture is fundamental to the future of our country. For years we have been in discussion, inconclusively, on how best to go about this. We have seen numerous initiatives. Many pilot projects. I believe that best policies are evidence-based and informed by compelling performance indicators. There is still a bit of work needed in the science community to identify broadly supported indicators that could best reflect the vitality of our science culture in Canada.

Canada’s science culture is shaped by the interplay of various public, private and non-profit players delivering a range of activities and tools designed to enhance understanding and interest, among Canadians of all ages, in science. There are hundreds of different formal and informal science education and awareness and awareness building programs in this country and we hardly can map out their contribution to the vitality of science culture in our country. We need to collect output and outcome indicators to start benchmarking our progress and devise an effective national strategy. For example we need to measure beyond literacy levels or number of graduates in STEM [science, technology, engineering, mathematics] to include such things as science coverage and audience in the media, public opinion on science and scientists and many other indicators used in other countries.

I’ve noticed that most of the discussion about innovation is centered on the notion of business; do you think that culture has a place at that table?

YES! Actually the concept of science culture reflects the fact that part of our general culture there has to be a strong dose of science. And creativity, innovation, risk taking, entrepreneurship. The business sector fully understands the crucial nature of a strong science culture as a driver to our country’s competitiveness.

Is there anything you’d like to add?

As members of the science community, it is our responsibility to ensure that Canadians recognize not only the great achievements of our scientists, but that they see how science-based evidence inform our everyday lives.

I believe that the same curiosity and joy of discovery experienced by young Canadians visiting our science museums and science centres can be shared by all Canadians. I believe that this can then be turned into an active commitment to make Canada a country where scientific discovery and innovation shape our identity as Canadians, and contribute to the health of our economy and to the vibrancy of our nation. Creative thinking and a spirit of entrepreneurship are at the heart of innovation. Creative thinking does not require a lot of raw material but is underpinned by a strong science culture. We need to foster and support that value.

Thank you Mme. Amyot for sharing your insights and enthusiasm about science culture and offering this preview of the 2011 CSPC ‘Science Culture’ panel in the midst of your busy schedule.

I am very grateful to you and Mike Harcourt, Tim Meyer, and David Kent for taking the time to answer my questions about your work and about your talks for the 2011 CSPC panels where you will be appearing over the next few days.

Building Stronger Communities through Innovation panel at the 2011 Canadian Science Policy Conference

Monday, November 7th, 2011

The 2011 Canadian Science Policy Conference (CSPC) scheduled for Nov. 16 – 18 in Ottawa, Ontario is featuring a couple of talks on innovation. Mike Harcourt, former Premier of BC, former Mayor and Councillor for the City of Vancouver, and a speaker on the Building Stronger Communities through Innovation panel, has very kindly answered a few questions about his work and the panel discussion.

First, here’s more about Mike Harcourt from his biography,

As former premier of British Columbia, Mayor of Vancouver and City Councilor,

Mike Harcourt helped British Columbia earn its reputation as one of the most livable, accessible and inclusive places in the world.  His focus on conservation and sustainable development – and his resolve to contribute to the transformation of cities and communities around the world – has played a significant role in promoting quality of life for those in Canada and abroad.

After stepping down from politics, he was appointed by the Prime Minister to serve as a member of the National Round Table on the Environment and Economy, where he served on the Executive Committee and Chaired the Urban Sustainability Program.  He was a federally appointed B.C. Treaty Commissioner and was Chair of the Prime Minister’s Advisory Committee for Cities and Communities and co-chaired the National Advisory Committee on the UN-HABITAT World Urban Forum in Vancouver in 2006.

Mike Harcourt is Chair of University of British Columbia’s Regional Sustainability Council for sustainability initiatives, and is at the new (CIRS) Centre for Interactive Research on Sustainability as well as Associate Director of the Centre for Sustainability Continuing Studies at U.B.C.  In addition to acting as Chairman of Quality Urban Energy Systems for Tomorrow (QUEST) www.questcanada.org, he chairs the Canadian Electricity Association’s Sustainable Electricity Program Advisory Panel. He is a member of City of Vancouver’s Greenest City Action Team. He also was part of an advisory group that helped Whistler put together its Natural Step based on sustainable cities strategy.  He is the lead faculty in United Way’s Public Policy Institute.

Harcourt’s exemplary career as Lawyer, Community Activist, and Politician has been honoured, with the Woodrow Wilson Award for Public Service and the Canadian Urban Institute’s Jane Jacobs Lifetime Achievement Award.  He was awarded the U.B.C. Alumni Achievement Award of Distinction for contributions to British Columbia,  Canada  and the global community  in November 2008.

U.B.C. Law Deans Advisory Council – 2010. Honorary Fellowship – The College of Fellows-Royal Architectural Institute of Canada.  In 2011 – Peter Lougheed Award in Public Policy.

In 1993 Al Gore applauded Premier Harcourt, for permanently preserving the jointly shared ecosystem of the Tatshenshini River and Alaska’s Glacier Bay National Park in Northwest British Columbia.

He is the author of: A Measure of Defiance and co-author of Plan B: one Man’s Journey from Tragedy to Triumph and co-author of City Making in Paradise.

Mike Harcourt is a Speaker and  Advisor  internationally on sustainable cities.

Here are the the answers that Mike Harcourt kindly took the time out of a very busy schedule to give,

  • I am a little curious as to how you ended up at a science policy conference. Have you had a particular interest in science or was this dictated by other forces and what would those forces be?

I’m at the conference (CSPC) as Chair of QUEST(Quality Urban Energy Systems of Tomorrow – QUESTcanada.org).  Plus I Chair the Canadian Electricity Association’s Sustainable Electricity Advisory Panel.  Innovation and technology are key to both organizations’ initiatives.

  • Can you offer a preview of what you, in particular, will be discussing at the Building Stronger Communities Through Innovation talk?

Most Canadians (95%) live in or around our 120 big and medium-sized communities, in the inner city, suburbs or rural areas just outside these cities so if we’re serious about having sustainable, competitive, Greenhouse-gas-reducing cities,we’ll need much greater emphasis on innovation, energy and technology applied to solving unsustainable patterns of urban planning and development.

  • Do you have any comments about the recent report on the Review of Federal Support to R&D, which was released with the title, Innovation in Canada: A Call to Action?

No comment on the recent Review of Federal Support to R&D Report.

  • As the former Premier of BC, what role to do you see for developing innovation and innovative communities at the provincial level?

 As Premier I saw an important role for provincial governments – good quality K-12,and post secondary education, R&D and commercialization initiatives,trade development.

  • As a former Mayor of Vancouver, what role to do you see for developing innovation and innovative communities at the municipal level?

 As Mayor I facilitated an economic development policy with a focus on innovation, trade development, proper zoning and taxation policies to encourage technology and related research, consulting and support enterprises.

Mike Harcourt, thank you very much for providing this preview of your talk on the panel and insight into how provinces and cities can encourage innovation.

Aptamers and Maria DeRosa

Tuesday, October 25th, 2011

Today’s (Oct. 25, 2011) next interview is with Maria DeRosa of the DeRosa Lab at Carleton University (Ottawa, Canada) where she and her colleagues work on bionanotechnology projects. (The Highlighting the 2011 Dance Your Ph.D. contest posting featured a Ph.D student from her lab who is one of this year’s contest finalists.)

Before proceeding to the interview, here’s a little bit about the DeRosa Lab (from the website homepage),

The first step in the rational design of novel bionanotechnology is to find the right molecular components for the task. Our group seeks to investigate the use of chemically-modified nucleic acid aptamers, single stranded DNA or RNA sequences that specifically bind to a diverse variety of targets, in biosensing and catalysis.

Here’s some information about Dr. DeRosa,

Dr. Maria DeRosa’s research examines a type of nucleic acid called ‘aptamers’ that can fold into 3D nanoscale shapes capable of binding tightly to a specific molecular target.  Her group is focused on developing a better understanding of how these systems and using this information to design useful nanotechnology, like biosensors or “smart” delivery devices.  Dr. DeRosa received her Ph.D in Chemistry from Carleton University in 2003 and was presented with a University Senate Medal. She was awarded an NSERC Postdoctoral Fellowship to do research at the California Institute of Technology from 2004-2005 with Prof. Jackie Barton, a world-leader in DNA sensor research. In 2005, she returned to Carleton as a faculty member in the Chemistry Department. Her research group has received funding from the Natural Sciences and Engineering Research Council (NSERC), the Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA), the Canada Foundation for Innovation (CFI) and Alberta Innovates Biosolutions.  DeRosa was a recipient of the John Charles Polanyi Research Award for new researchers in 2006 and an Ontario Early Researcher Award in 2010.

Here’s the interview,

*   Are you one of those people who always wanted to be a scientist or was this something you discovered later?

I was never one of those people who knew what they wanted to do from an early age.  I thought about being a doctor, pharmacist, plumber, engineer, bank teller…  In high school, I had many great math and science teachers that inspired me to go into science when I started at Carleton University.  Then, in my third year I got a summer job working in Dr. Bob Crutchley’s research lab.  He was a great mentor and it was then that I started seriously thinking about a career as a scientist.  I loved the idea of research, that I was working on a problem and no one knew what the answer would be.  I wanted the answers!

*   How did you get interested in aptamers (and could you briefly describe what they are)?

Aptamers are synthetic pieces of DNA that can recognize and stick to a molecular target.  The targets can vary from things that are very small, like a drug molecule to something much larger, like bacteria or viruses.  Because they can recognize and stick to other molecules, people are interested in using them as receptors for sensors.  I had never even heard of them until about 2005.

After my Ph.D., I went to Caltech to do something called a postdoctoral fellowship.  It was a research position in the lab of Dr. Jackie Barton, one of the world’s top DNA researchers (she just won a National Medal of Science a couple days ago).  She wasn’t working with aptamers but she opened me up to the idea of using DNA in an “unnatural” way.  Most of us, when we are thinking of DNA, we think of our genes and that it is the blueprint for life.  But from a chemistry point of view, DNA is just another material that has certain chemical properties that can be useful for other applications.  In Jackie’s lab, I learned how to make synthetic DNA and I started reading about aptamers.  I found the whole field fascinating and I knew that I wanted to be a part of it.

*   What applications are there for your work? (I noticed that you discussed fertilizers in your TEDxCarleton talk. Is agriculture an area of particular interest?)

Applications for aptamers mostly stem from their ability to bind tightly and selectively to other molecules.  So, they are typically used in technology such as biosensors where they can serve to detect low levels of something, like a toxin or a virus for example, in another matrix.  We’re developing aptamers for the detection of mycotoxins (toxins that come from moulds) in crops and food.  We’re also working on aptamers for norovirus (the virus that causes Norwalk, that awful stomach bug) so that we can catch it if it is in meat and other foods before they get sent off to stores.

We are also trying to use aptamers for triggered delivery of drugs and/or nutrients.  In many cases with drugs, we want them to act on certain cells or tissues and not on others.  So, we need to be able to control where the drug is released in the body.  There is a similar problem in agriculture.  We want to give crops certain nutrients from fertilizers but if we deliver them at the wrong time, they will be washed away and not taken up by the crop.  This leads to major economic losses for the farmer and problems for the environment.  With our work, the idea is that we use the aptamer to control the release of whatever we are delivering.  We incorporate the aptamer into a coating that covers the drug or nutrient.  The aptamer is there to recognize a stimulus that we want to use to release the contents.  For drug delivery, that stimulus might be a cancer cell or a disease biomarker.  For fertilizers, that stimulus might a be a plant signal that corresponds to the plant’s need for nutrients.  (We are working with Dr.Carlos Monreal from Agriculture and Agrifood Canada on the fertilizer project, and he is an expert in these plant signals and ‘smart fertilizers’.)  In the absence of that signal, the coating does not allow the release of the drug or nutrient.  But, once the aptamer recognizes that key signal, the aptamer distorts or destroys the coating and it allows the nutrient to be released.

*   According to the information on your lab website, you are the recipient of Canada Foundation for Innovation (CFI) Leaders Opportunity Fund (LOF) monies. Are these funds being applied to a particular project in your lab or are they used to support your general area of research?

CFI funds helped us to build our facility called the LADDER (Laboratory for Aptamer Discovery and Development of Emerging Research applications).  That funding allowed us to get the state-of-the-art equipment we need to support all of our research projects.  Without CFI funding, our work would not be possible!

*   Given your TEDxCarleton talk and your involvement in the 2011 Canadian Science Writers conference (researchers’ speed dating [I couldn't confirm it but I'm pretty sure I saw your name listed for this event]), I gather you’re quite interested in public outreach. Why do you think it’s important?

Yes, I was at that ‘speed dating’ event and I am very committed to science outreach.  The public helps to support my research through funding like NSERC and CFI, so I think it is critical that I can explain to them what it is that I do, why it is important, and why their money is well-spent.  The general public may not know what an aptamer is, but they all realize the importance of keeping our food free of toxins or the need to make drugs that are better able to target disease.

*   I noticed that one of your students is a finalist in the Dance your Ph.D 2011 contest. And it’s not the first time. Do you find a lot of scientists with ‘dance’ tendencies are attracted to your lab? Are you one of those scientists?

My students won the competition last year and then they were finalists again this year!  I’m not sure if dancers are attracted to my lab or if my students are just as committed to outreach as I am!  My students are very excited to talk about their research with anyone who will listen.  This contest is a fun way to explain their work to everyday people.  Friends and family, after watching these dances online, have told me that they finally understand what is going on in my lab.  Maybe I should dance more!  (I’m not a dancer and you will not find me in either video…I support them from the sidelines!)

*   Is there anything you would like to add?

Thanks for profiling me and it has been fun!

Maria, thank you for this intriguing peek into your research, the field of DNA nanotechnology, and your (and shared by your students) commitment to public science outreach. I’m very happy you managed to cram the time to answer these questions into your schedule.

Reaching out with big science panel at the 2011 Canadian Science Policy Conference

Tuesday, October 25th, 2011

Today’s 2011 Canadian Science Policy Conference (CSPC) interview is with Dr. Tim Meyer, Head of Strategic Planning & Communication for TRIUMF who will be one of the presenters on the Reaching out with big science panel. Here’s a little more about Tim (from Tim Meyer’s profile page on the TRIUMF website),

Dr. Timothy Meyer came to TRIUMF from the U.S. National Academies in Washington, D.C.. At the National Academies, Meyer was a senior program officer at the Board on Physics and Astronomy. He received a Notable Achievement Award from the [US] NRC’s Division on Engineering and Physical Sciences in 2003 and a Distinguished Service Award from the National Academies in 2004. Meyer joined the NRC staff in 2002 after earning his Ph.D. in experimental particle physics from Stanford University. His doctoral thesis concerned the time evolution of the B meson in the BaBar experiment at the Stanford Linear Accelerator Center. His work also focused on radiation monitoring and protection of silicon-based particle detectors. He is a member of the Canadian Association of Physicists, Canadian Science Writers Association, American Physical Society, American Association for the Advancement of Science, Materials Research Society, and Phi Beta Kappa.

Here’s a little more on the Reaching out with big science panel. From the CSPC agenda page,

The public often learns of developments in science in the media distilled from press offices at peer-reviewed journals or universities. In a few cases, research institutions such as the Mayo Clinic and CERN have also developed a reputation for being seen as authoritative sources of science news and information for the public. In recent years, the Canadian research landscape has grown to feature a number of ‘big science’ facilities. These institutions, such as TRIUMF, Ocean Networks Canada, the Canadian Light Source, SNOLab and the Perimeter Institute, conduct research at the forefront of science – often at the convergence of science disciplines and with a scope and scale that is larger than traditional research institutions in government or the academy. In addition to research, all of these laboratories also engage in a number of forms of public engagement and outreach, ranging from media relations to classroom education. In a media landscape where science reporting is becoming increasingly fractured, what role do Canada’s big science facilities have in being sources of science news, information and education?

Here is the interview that Tim kindly gave during a period when he has been traveling extensively on behalf of TRIUMF,

  • For those who are not familiar with TRIUMF could you please give a brief description of it and an explanation of how it fits into the Canadian science landscape?

TRIUMF IS CANADA’S NATIONAL LABORATORY FOR PARTICLE AND NUCLEAR PHYSICS.  IT IS OWNED AND OPERATED BY A CONSORTIUM OF 17 CANADIAN UNIVERSITIES FROM COAST TO COAST.  TRIUMF WAS FORMED MORE THAN 40 YEARS AGO TO POOL RESOURCES AND TALENTS FOR RESEARCH INFRASTRUCTURE THAT WAS TOO COMPLEX AND EXPENSIVE TO MAINTAIN BY A SINGLE UNIVERSITY.

THE TRIUMF TEAM INCLUDES ABOUT 350 STAFF ON 12 ACRES IN VANCOUVER ON THE SOUTH SIDE OF THE UBC CAMPUS. TRIUMF OPERATES 5 DIFFERENT ACCELERATORS INCLUDING THE WORLD’S LARGEST CYCLOTRON.

TRIUMF IS UNIQUE IN CANADA AND ONE OF THE TOP THREE LABORATORIES IN THE WORLD FOR CAPABILITIES TO RESEARCH AND DEVELOP ISOTOPES FOR SCIENCE AND MEDICINE.

TRIUMF IS ONE MEMBER OF A FAMILY OF NATIONAL LABORATORIES IN CANADA INCLUDING THE CANADIAN LIGHT SOURCE [represented on the panel], SNOLAB, PERIMETER INSTITUTE [represented on the panel], AND THE CANADIAN NEUTRON BEAM CENTRE.

  • I’ve read the description for this panel and wonder how this fits into a science policy conference. Is there going to be some link made between public engagement and public policy?

ABSOLUTELY. THIS PANEL SESSION SHOWS UP FOR TWO REASONS.  FIRST, PUBLIC ENGAGEMENT IS PART OF THE OBLIGATION OF PUBLICY-FUNDED RESEARCH ACTIVITIES.  EITHER TO SHARE THE BENEFITS OF THE RESEARCH OR SHARE THE INSPIRATION THAT COMES FROM DISCOVERY… OR ANY OTHER NUMBER OF REASONS.  SO IN THE CONTEXT OF SCIENCE POLICY, THIS PANEL WILL DISCUSS HOW THE PUBLIC ENGAGEMENT AND “SHARING” FROM LARGE SCIENCE FACILITIES MIGHT DIFFER FROM THAT OF INIDIVUAL RESEARCHERS—OR EVEN WHETHER LARGE SCIENCE FACILITIES HAVE A LARGER OBLIGATION.

SECOND, LARGE SCIENCE FACILITIES PRESENT A CHALLENGE FOR TRADITIONAL SCIENCE POLICY BECAUSE THEY REPRESENT LARGE UP-FRONT CAPITAL COMMITMENTS WITH SIGNIFICANT ONGOING OPERATING COSTS.  WHAT IS THE RESPONSIBLE APPROACH FOR MANAGING A PORTFOLIO OF THESE LABORATORIES?  IN THIS PANEL DISCUSSION, WE WILL BE LOOKING AT THE SOME OF UNIQUE FEATURES OF NATIONAL SCIENCE FACILITIES THAT MAKE THEM INVALUABLE AS WELL AS OUTLINE SOME ROUTES FOR IMPROVING THEIR STEWARDSHIP.  SO THIS PANEL DISCUSSION WILL ENGAGE THE ENGAGERS IN AN ENGAGING CONVERSATION!

  • Could you briefly discuss some of the public outreach and engagement initiatives taken by TRIUMF?

TRIUMF’S STRATEGIC PLANNING AND COMMUNICATIONS OFFICE (SPCO) OVERSEES PUBLIC RELATIONS, CONFERENCE SERVICES, PUBLICATIONS, AND EDUCATION AND OUTREACH ACTIVITIES AT THE LAB.  FOR INSTANCE, TRIUMF CO-SPONSORS A MONTHLY LECTURE SERIES FOR HIGH-SCHOOL STUDENTS ON BREAKING-NEWS TOPICS IN PHYSICS FOR PEOPLE IN THE VANCOUVER METRO AREA.  TRIUMF ALSO SELECTS 2-3 OF THE TOP BC AREA HIGH SCHOOL STUDENTS AND WARDS THEM A SUMMER RESEARCH FELLOWSHIP AT THE LAB ALONGSIDE THE WORLD’S BEST SCIENTISTS.  TRIUMF ACTIVELY PARTICIPATES IN CONVERSATIONS TO ENGAGE THE PUBLIC ABOUT THE NATURE AND IMPORTANCE OF SCIENCE.  DURING THE FIRST MONTH AFTER THE FUKUSHIMA CRISIS, TRIUMF PROVIDED INVALUABLE COUNSEL TO GOVERNMENT AGENCIES AND THE MEDIA ABOUT WHAT WAS ACTUALLY GOING ON.  ELSEWHERE, TRIUMF HAS PROVIDED EXPERTS TO SCREENINGS OF SCIENCE-RELATED FILMS PART OF THE VANCOUVER INTERNATIONAL FILM FESTIVAL.  WE ALSO USE TWITTER TO CALL ATTENTION TO IMPORTANT SCIENCE DEVELOPMENTS AND WE ARE DEVELOPING A LIBRARY OF ENTERTAINING “BEHIND THE SCENES” VIDEOS ON OUR YOUTUBE CHANNEL ABOUT RESEARCH AT TRIUMF.  TRIUMF HAS BEEN AN OPINION AND TECHNOLOGY LEADER IN CANADA’S DISCUSSION ABOUT THE MEDICAL-ISOTOPE CRISIS, ANOTHER EXAMPLE OF PUBLIC ENGAGEMENT ON POLICY TOPICS SHAPED BY SCIENCE AND TECHNOLOGY.

  • I’m surprised by the failure to include social media as part of the new science communications landscape. Do you have any thoughts on that exclusion?

WHAT MAKES YOU THINK IT’S NOT INCLUDED? YOU HAVEN’T SEEN THE TALKS YET!  JUST TEASING.  WE WILL ALL CERTAINLY BE TALKING ABOUT SOCIAL MEDIA AND WE’LL EVEN BE TWEETING AND BLOGGING LIVE FROM THE CONFERENCE.

  • Can you offer a preview of what you, in particular, will be discussing during the panel session?

WELL, I DON’T SPOIL EVERYTHING, BUT HERE’S WHAT I CAN SAY IN ADVANCE.  I WILL BE TALKING ABOUT THE SET OF MOTIVATIONS FOR PUBLIC ENGAGEMENT FOR RESEARCH LABORATORIES.  NATIONAL SCIENCE FACILITIES ARE NOT THE BE-ALL, END-ALL FOR RESEARCH AND SCIENCE COMMUNICATION, BUT THEY PLAY A CLEAR, UNMISTAKABLE ROLE THAT IS INCREASINGLY IMPORTANT. I WILL DISTINGUISH THE RESPONSIBILITIES OF A NATIONAL SCIENCE FACILITY FROM THOSE OF INDIVIDUAL RESEARCH EFFORTS.  I WILL ALSO DISCUSS HOW THE PUBLIC ROLE OF A LABORATORY IS EVOLVING IN THE INTERNATIONAL CONTEXT AS WELL AS THE VERY-MUCH-IN-DEMAND CONTEXT OF INNOVATION AND COMMERCIALIZATION.

  • Is there anything you would like to add?

(1) MANY FEEL THAT PUBLIC OUTREACH AND EDUCATION IS JUST A SELF-SERVING TRICK OF SCIENTISTS—IF MORE PEOPLE KNOW ABOUT SCIENCE, THEY’LL LIKE IT, AND THEN WANT TO SPEND MORE TAX DOLLARS ON IT.  THIS SIMPLISTIC LOGIC HAS ACTUALLY BEEN SHOWN TO BE FALSE.  THERE IS NO PROSELYTIZING GOING ON.  WE’RE NOT HERE TO MAKE YOU LIKE SCIENCE SO YOU LIKE US!  WHAT THIS IS ABOUT IS GIVING BACK TO KEY ELEMENTS OF THE PUBLIC AND ABOUT ADVANCING SOCIETY.

(2) THE CANADIAN SCIENCE POLICY CONFERNECE IS AN IMPORTANT STEP FORWARD FOR CANADA.  IT AIMS TO PROVIDE A FORUM FOR KEY ISSUES TO BE DISCUSSED AND EXAMINED.  THE KEY CHALLENGE IS TO DRIVE THE FIELD FORWARD BY RESOLVING SOME OF THESE ISSUES.  BETTER AND BETTER INFORMED HAND-WRINGING ABOUT THE STATE OF SCIENCE OR INNOVATION (I.E., JUST COMPLAINING) IN CANADA IS GOING TO GET OLD.  THE OPPORTUNITY OF THIS CONFERENCE, AND THE INTENTION OF THE ORGANIZERS, IS TO START TO GENERATE A NEW CONVERSATION.  WHAT ARE THE BASELINES EXPECTATIONS FOR SCIENCE?  WHAT RESULTS HAVE WE ACHIEVED WITH OUR RECENT INNOVATIVE PROGRAMS?   WHEN WE LOOK AT THESE QUESTIONS, WE START MOVING THE ENTIRE COUNTRY FORWARD.

Thank you, Tim. I’m very grateful you managed to squeeze this interview into your schedule. I imagine this will be a lively presentation given your comments.

Education and training of scientists panel at the 2011 Canadian Science Policy Conference

Monday, October 24th, 2011

On the heels of my last posting which featured Science magazine’s 2011 Dance Your Ph.D. contest, it seems like a good idea to follow up with another science student-themed posting.

Dr. David Kent who will be moderating the Education and training panel at the 2011 Canadian Science Policy Conference (CSPC) being held in Ottawa, Canada from Nov. 16 – 18, 2011 has enthusiastically granted me an interview. (My Oct. 19, 2011 posting featured a description of the 2011 CSPC conference and highlighted some of the events.)

First, here’s a little bit about David (from the 2011 CSPC conference website),

Dr. David Kent is a CIHR [Canadian Institutes of Health Research] postdoctoral fellow at the University of Cambridge, UK. He currently sits on the executive of the Canadian Association of Postdoctoral Scholars and created the website The Black Hole which provides information on and analysis of issues related to science trainees in Canada. Previously, Dr. Kent served as joint coordinator for the UBC branch of the Let’s Talk Science Partnership Program (2004-07), an award winning national science outreach program. Dr. Kent grew up in St. John’s, NL, obtained a B.Sc. in Genetics and English Literature at the University of Western Ontario and completed his Ph.D. in blood stem cell biology at the University of British Columbia. He has been awarded scholarships or fellowships from the CIHR, NSERC, the Canadian Stem Cell Network, the Michael Smith Foundation for Health Research, and the Lady Tata Memorial Trust. His current laboratory research focuses on normal blood stem cells and how changes in their regulation lead to cancers.

Here’s the description of the panel (Education and training of scientists) David will be moderating,

Over the past 15 years, there has been an enormous shift in the human resources performing scientific research. The training period has lengthened significantly and adjustments must be made to address the growing concerns of young scientists. Many individuals, who do not have permanent positions, share a unique set of experiences and challenges that need to be better addressed in order to avoid wasting the substantial resources invested in their education and training.

This panel aims to address two main themes:

  1. Are we producing too many biomedical research trainees?
  2. What careers will the large majority of highly specialized PhDs undertake and who should facilitate these transitions?

Presentations and discussion from Alan Bernstein (Founding Director of CIHR), Angela Crawley (Canadian Association of Postdoctoral Scholars), Suzanne Fortier (President of NSERC), and Olga Stachova (COO, MITACS) will be introduced and moderated by David Kent (University of Cambridge and founder of http://scienceadvocacy.org, aka The Black Hole).

Here’s  the interview,

  • I’m intrigued by the description for this panel which asks a highly specific question (Are there too many biomedical research trainees?) and a much more general question (What careers will the majority of highly specialized PhD undertake and who should facilitate the transition?). Assuming that you proposed the panel, how did you arrive at these two questions in particular?

The first question definitely has its origins in Jeff Sharom’s piece in Hypothesis Journal (http://www.hypothesisjournal.com/pdfs/vol6num1/17.pdf) who queried whether we were producing too many biomedical trainees.  It is also a great way to capture a large issue under a simple title, but by no means would I consider it specific and I think just about anybody you ask would have the answer “it depends…” followed by discussions ranging from the demands of a knowledge-based economy to keeping young people out of the workforce for a few more years.

As for the second question, I see this one having a much more straightforward answer as it is really an attempt to assign responsibility to a sector of society to help deal with the problem – I’d like the panel and delegates to help steer future advocacy efforts to address the fundamental issues.

  • Given that you are currently working as a postdoc at the University of Cambridge, would you be asking these same questions on a UK panel and if not, why not?

The UK is a very different beast, but I think there is still overlap – in particular, the challenges facing those seeking an academic post and those debating whether or not to leave the academy.  The one thing that is very different in the UK – and I’m torn as to whether or not it’s a good thing or a bad thing – is that time-to-degree is substantially shorter with PhD programs lasting 3-4 years.  If you’re equipping people to go off into other careers, this is brilliant because they don’t get stuck in a very long PhD, but rather come out with the nuts and bolts of a PhD training.  However, this sort of system also tends to lead to what I would call “safe” projects that will yield results in the limited time frame and leave little room for exploring risky projects.  We talk about this in an old entry on the Black Hole called “The Rise of the Cookie-cutter PhD” (http://scienceadvocacy.org/Blog/2009/11/17/science-is-like-baking-the-rise-of-the-cookie-cutter-phd/)

  • Will you be acting as a moderator only or will you also speak to the questions? If you do speak to the questions, could you give a preview of your presentation?

I will introduce the panel and in doing so will try to set the stage for the audience – chart the change in demographics, highlight the issue of career stasis in academic labs, etc.  Much of my presentation will draw from entries on the Black Hole such as the Changing Human Resources in AcademiaSay no to the second Postdoc, and Professionals in High Demand.  Briefly, I’ll show statistics on the longer training times and summarize the unrest in academic labs.  In the moderation of the panel discussion, I’ll include some resources on how some universities have started to tackle the issues and some innovative programs that are helping young academics make choices sooner.

  • What do you hope will be the outcome(s) of having this panel at the 2011 CSPC?

For me, the biggest mission is awareness – I want policy makers, granting councils, and industry leaders to recognize the growth in highly trained scientists and the immense number of talented people that often finds themselves “stuck”.  These are people who have trained for nearly a decade and only a fraction of them can end up on the path they have been trained for (unlike doctors, lawyers, accounts)

A complete bonus would be to get some strategies for unsticking these people and some guidance on where to broach the issue.  We’ll see how it goes!

  • Is there anything you would like to add?

The only final thing I would suggest is for young scientists who have any sort of inclination toward or interest in science policy to get out there early – two or three days at a conference like the CSPC can be career changing or it could simply allow you to better understand the machinery that ends up impacting how you will be funded, how your trainees will be trained, and how research gets (or doesn’t get) incorporated into government policy.  Take off the blinders once in a while and try something new.

Thank you for taking the time to provide some insight into your topic and your presentation. I wish you and your panel the best of luck at the conference.

ETA Nov. 9, 2011: For Twitter purposes I decided to call this panel the ‘Kill all your darlings/science grads” panel. “Kill all your darlings” is a phrase I came across that describes what writers sometimes have to do when they edit a piece and must cut a wonderful sentence or phrase because it doesn’t fit. I gather that there is a problem (not only in Canada) with fitting science grads into the larger science enterprise.

Dr. Andrew Maynard discusses the Health Canada nanomaterial definition

Monday, October 24th, 2011

I have often referred to and linked to Andrew Maynard’s writing on nanotechnology issues and am pleased to note he has kindly answered some questions about the Health Canada Working Definition of Nanomaterial. Before launching into his responses, here’s a little more about him.

Dr. Andrew Maynard was originally trained as a physicist and graduated with a PhD from Cambridge, UK  in 1993. He worked for a number of years for the UK Health and Safety Executive moving to the US to work with the National Institute of Occupational Health and Safety where he helped set up a nanotechnology safety programme post 2000 when the NNI was established. By 2005, he was employed at the Project on Emerging Nanotechnologies as their Chief Science Advisor. As of April 2010, he assumed responsibility as director of the Risk Science Center at the University of Michigan School of Public Health. He consults internationally on nanotechnology safety issues. He was a member of the expert panel consulted for the nanotechnology report, Small is Different; A Science Perspective on the Regulatory Challenges of Nanotechnology, published by the Council of Canadian Academies in 2008.

Since the 2008 report for the Council of Canadian Academies, Andrew has adopted a different approach to regulating nanotechnology, a change I first noted in an April 15, 2011 posting on the University of Michigan Risk Science Center blog. Excerpted from that posting,

Engineered nanomaterials present regulators with a conundrum – there is a gut feeling that these materials present a new regulatory challenge, yet the nature and resolution of this challenge remains elusive.  But as the debate over the regulation of nanomaterials continues, there are worrying signs that discussions are being driven less by the science of how these materials might cause harm, and more by the politics of confusion and uncertainty.

The genesis of the current dilemma is entirely understandable. Engineered nanomaterials are typically the product of nanotechnology – a technology that has been lauded as leading to designed materials with unique physical and chemical properties.   Intuitively it makes sense that these unique properties could lead to unique risks.  And indeed a rapidly growing body of research is indicating that many nanoscale materials behave differently to their non-nanoscale counterparts in biological environments. Logically, it seems to follow that engineered nanomaterials potentially present risks that depend on their scale, and should be regulated appropriately.

Yet the more we learn about how materials interact with biology, the less clear it becomes where the boundaries of this class of materials called “nanomaterials” lie, or even whether this is a legitimate class of material at all from a regulatory perspective.

I waffle somewhat largely due to my respect for Andrew and his work and due to my belief that one needs to entertain new approaches for the emerging technologies, even when they make your brain hurt. (Before proceeding with Andrew’s comments and for anyone who’s interested in my take here is, My thoughts on the Health Canada nanomaterial definition.)

In any event, here are Andrew’s responses to my questions,

  • I have warm feelings towards this definition, especially the elaboration where I think they avoided the problem of including naturally occuring nanoparticles (as per your comment about micelles in milk); and they specify a size range without being doctrinaire about it. How do you feel about it, given that you’re not in favour of definitions?

The problem is that, while the Health Canada is a valiant attempt to craft a definition based on the current state of science, it is still based on a premise – that size within a well defined range is a robust indicator of novel risk – that is questionable.  Granted, they try to compensate for the limitations of this premise, but the result still smacks of trying to shoehorn the science into an assumption of what is important.

  • Do you see any pitfalls?

A large part of the problem here is an attempt to oversimplify a complex problem, without having a clear understanding of what the problem is in the first place.  Much of my current thinking – including questioning current approaches to developing definitions – revolves round trying to work out what the problem is before developing the solution.  But this makes commenting on the adequacy or inadequacy of definitions tricky, to say the least.

  • Is there anything you’d like to add?

My sincere apologies, I’ve just got to 5:00 PM on Sunday [Oct. 23, 2011] after working flat out all weekend, and am not sure I have the wherewithal to tackle this before collapsing in a heap.

I am hugely thankful that Dr. Maynard extended himself to answer my questions about the Health Canada definition of nanomaterial. To Andrew: a virtual bouquet of thanks made up of the most stunning flowers and scents you can imagine.

Interview with the Urbee car’s Jim Kor

Wednesday, September 28th, 2011

In an earlier posting today, (Manitoba’s Urbee) about the Urbee, I promised an interview with Jim Kor, project leader and lead designer. Befoe getting to the interview, here’s a little biographical information from the Urbee website’s Team page,

Jim Kor is a professional engineer (mechanical) with over 35 years of experience in designing automotive, bus, rail, agricultural, and heavy mobile equipment as well as civil structures and product for the aerospace and medical industries. He is the senior designer and project leader for the Urbee project. Jim is the owner of Kor Product Design, a 30 year old international consulting firm.

Congratulations on your achievement, i.e., getting your first prototype completed. Could you describe the 3D printing process in simple terms? (e.g. do you lay down layers of atoms? particles? bits of polymer?; what does a 3D printer look like compared to the printers most of us are accustomed to?; etc.)

The 3-D printing process is an additive process, where a ’3-D printer’ precisely places a material (such as plastic), thin strands or particles at a time, layer by layer, with each layer bonding to the next, all under computer control, until a rigid part emerges. These 3-D printers look like large metal boxes, and can be the size of bar-fridges (desktop models) or walk-in freezers (floor-mounted models). The input to the machine is strands of material (wound in loops, like wire), and the output is finished parts.

Has this 3D printing process been enabled by nanotechnology?

Yes, I believe so. The head, where the material emerges hot and bonds to the lower layer, is where all the action takes place, and most of the technology is focussed.

Is every single element (tires, windows, seats, panels, etcl) of this car produced by 3D printing?

On our first prototype Urbee, just the body panels are 3-D printed. All the windows were also 3-D printed, but these 3-D printed parts were used as patterns for making the plastic and glass windows within Urbee.

How long does it take to print a piece?
The larger pieces currently can take a long time, or at least they did on our first prototype. But, we are learning, and this machine time will come down, especially with further progress regarding the printing of larger panels.

I gather you’re raising funds for your 2nd prototype. Is that one going to be identical to the first or are you refining the design and how?

The second prototype will greatly benefit from the first prototype (the first time we have seen all major components working within the car). We plan on refining and expanding our use of 3-D printing, taking it into the interior and parts of the chassis.
How close is your product to being commercialized and what would it take to get it commercialized?

We are at first prototype stage. Most optimistic production date would be 2014. It will take continued Research & Development by our Team to get us there.

Could you tell me a little bit about how this project came to be located in Manitoba?

The originators of the project, and most of the Urbee Team lives and works (as designers and engineers) in Winnipeg, Manitoba, Canada.

Have you gotten provincial and federal support for this project? And, if any, what kind? Have you also gotten support from venture capitalists, banks, etc.?

We have gratefully received financial assistance, but the project remains largely self-funded. Without financial assistance (especially donations), and without the expertise and in-kind support of our sponsors (as listed on our website), the project could not have advanced to the point it has. We continue to receive fantastic support from some of the best people, within some of the best companies and organizations in the world. Hats off to them for making this project what it is today.

On a completely different note, Urbee sounds like Herbie, the name of a Volkswagen beetle featured in a number of Disney movies. Was this intentional?

No, it was not intentional. URBEE stands for URBan Electric with Ethanol as back-up. It is a project name that has stuck, is rather unique (easy to do google searches), and which I personally have grown to like. I don’t mind being associated with the original VW Beetle, one of the best-selling cars in the world, … ever, …. (over 24 million units sold worldwide, I believe).

Why did you choose that particular colour for your prototype?

The Industrial Designers within the Team chose the colour. They are extremely talented (the best in the world, in my opinion). They have designed the body to not only look aesthetically pleasing and ‘correct’, but have achieved a Coefficient of Drag (Cd) of 0.15, … extremely low for a practical car. Some would say impossibly low, but two independent computer aerodynamic simulations have verified this number, so we are satisfied that we are there. It is what makes us claim that ‘One day all cars will look like this’, because this body shape honours the physics of the problem (a car body moving at the bottom of an ocean of air).

Is there anything you’d like to add?

Yes. Thanks to all those that have helped advance this groundbreaking and important project. Thanks for your interest in this project, that is helping propel it forward. And keep your eye on our website (www.urbee.net), to see where we’re going next.

Thank you and I wish you and your team the best of luck, Jim Kor.

Here’s one more look at the Urbee,

Urbee rear side at TEDxWinnipeg Sept. 15,2011

ETA Sept. 28,2011 11:50 am PST: I’ve corrected a few grammatical and spelling errors of my own. I am including two videos featuring the Urbee. The first is promotional video produced by the Urbee team,

This second video is a clip from a television programme interview of Jim Kor and Jeff Hanson discussing the 3D printing process and the Urbee,

Tim Harper, Cientifica’s CEO, talks about their latest report on global nanotechnology funding and economic impacts

Friday, July 15th, 2011

A big thanks to Tim Harper for both his insight and for taking the time to answer questions I had about the report, Report on Global Nanotechnology Funding and Impact (Global Funding of Nanotechnologies and Its Impact) released earlier this week on July 13, 2011.

(a) First, could you tell me a little bit about you and about Cientifica?

My background is hardcore nanotechnology – I spend years building and installing surface science instrumentation for VG Instruments, one of the first companies to commercialise the Scanning Tunnelling Microscope, or at least we did our best. But that was back in the days when a PDP 1-11 was the data system and successfully acquiring an image and interpreting it usually required a trip to Zurich to see Gerd Binnig and Heini Röhring [Note: They won the Nobel prize for their efforts on scanning tunnelling microscope]. I also spent a lot of time on Secondary Ion Mass Spectrometry – hitting surfaces with beams of ions and then collecting what we knocked off.  After that I ran the electron microscopy section at the European Space Agency’s (ESA) labs in Holland before buying a lot of focussed ion beam systems and atomic force microscopes so that we could take things apart atom by atom if we suspected that they may fail half way to Mars!

Cientifica started off as a spin out in 1996 doing contract research for ESA before moving into networking scientists, advising venture capital firms about technology and producing information about nanotechnologies. Over the past ten years our work has been used by most governments, and we have been instrumental in designing or advising on a large number of national nanotechnology projects. After tracking nanotechnology for 12 years and usually being more or less right (blush) we have an increasing number of people who use us as a sanity check for projects and investments. But often the biggest successes are the least visible such as advising a client not to put a few hundred million dollars into manufacturing carbon nanotubes for which there was no channel to market.

(b) Is your latest report, 2011 Global Funding of Nanotechnologies and Its Impact, a successor of sorts (industrial sectors rather than countries are prominently listed) to your 2008 Nanotechnology Opportunities report?

It’s a progression from our first edition of the Nanotechnology Opportunity Report in 2002. In those days people just wanted to know what nanotechnology was, and to cut through a lot of the hype and disinformation. In 2002, 99.9% of people thought that nanotechnology was all about tiny robots. Ten years later it’s probably 90%, but at least the 10% involved in science policy, whether in government or companies know what nanotech really is. What people want now is some usable information  –  how does it affect my business or industry, and how can I take advantage of it. Most of our work is for private clients, who range from start ups through to multinationals and governments, and who tap our expertise in predicting the future impact of technology.

We still do a huge amount of work in industrials sectors, and we have publications in medicine and energy in the pipeline which we hope will allow people to cut through the hype and understand what (and when) the market opportunity will really be.

(c) Why did you choose to focus on nano R&D spending and potential economic impacts? Is it something to do with all of the talk about innovation?

We wanted to look first at the funding in both dollar and purchasing power parity terms as one R&D dollar gets more in China that it does in the US. There is a lot of national pride at stake about who is spending the most, and if you look at per capita spending it gets even more interesting. But getting technology to market isn’t just about making huge amounts of government money available. 90-95% of science funding doesn’t generate anything of any economic use (although it can be very useful for furthering scientific knowledge) so we need to look at how that 5-10% gets to market.  I have had a close relationship with the World Economic Forum for many years which also helps us move away from merely looking at science funding to looking at its economic impact, and we also use a lot of data from the World Bank, OECD [Organisation for Economic Development and Cooperation], and various government studies when we try to model technology diffusion.

Over the years we have developed a quite sophisticated model that allows us to translate these various inputs into fairly good, and quite specific, market predictions. In the past 12 years some people have described our market forecasts as cynical or ultra conservative, but if you look back at what we’ve said and what actually happened, I think you’ll find that we were just being realistic. I know that some people want to see big numbers, but it must be all those years as a scientist that makes me satisfied with accurate numbers, no matter what the magnitude!

Innovation isn’t a problem, the academic system is stuffed to the gills with bright and innovative people, but convincing the rest of the world that they need your innovation is the stumbling block. When we looked at the ability of countries to take advantage of their technology funding, countries such as the US and Germany scored highly as they have plenty of commercial-facing research, a strong tradition of industry-academic partnerships, good government support for technology (and whatever individual academics may say it could be far far worse) and domestic industry hungry for technology to maintain their competitive advantage. What surprised us was the low ranking of the UK. While possessing some of the best universities in the world, the UK economy is predominantly service-based, and real estate and coffee shops tend to be less enthusiastic consumers of nanotechnology than chemical companies and auto manufacturers.

(d) It seems most countries are concerned/worried about the levels of their nano science research, their innovation, and consequent economic prospects. Is there any country that seems confident about its nano economic prospects and why do you think that is?

That is partly true, but most governments do not have a joined up strategy which can cause significant structural problems in the future. Post financial crisis, the emphasis has shifted to trimming budgets rather than making long term strategic investments, which is what nanotechnology is, and this gives us two major problems.

Firstly, there just isn’t enough support for early stage spin outs. There is a financial desert to cross between being a full time academic and having a company with enough proof of concept to attract angel or VC [venture capital] funding. Unless governments address this aspect it really doesn’t matter how much innovation is produced by the academic sector, most of it will go nowhere (other than the parts cherry picked by large companies). We really need to start thinking about the path that innovation takes to market, and to make that as smooth as possible.

Secondly, and more seriously, we are approaching a dangerous time in human history. Science and technology are moving faster than ever before thanks to the automation of lab systems and almost real time sharing of results through online journals. At the same time, people are increasingly distrustful of technology, perhaps as a result of it being so far removed from everyday life, which leads to whole areas of science such as GMOs [genetically modified organisms] or nuclear energy becoming tainted. So while we have increasing pressure on food, water, energy, health and every other resource caused by a rising global population, we are being denied the tools which could help improve the conditions of people across the globe. I’m deeply involved in an initiative that sprung from our emerging technologies work at the World Economic Forum, which involves the setting up of a global Centre for Emerging Technologies Intelligence, with the aim of ensuring that we can and will develop the technologies needed to provide clean water, better health and cheap food to the world, whether that comes from nanotechnology, industrial biotechnology, or any other emerging technology.  But the project is less about the technology than making sure that the importance of technology is recognised by governments and international organisations. It is no good running around firefighting crises when we could be thinking ahead and averting them. There’s still a long way to go, but we are talking to a number of governments who are keen to host the centre.

(e) I find it interesting that regions/countries (Alberta, Texas, Iran, and increasingly, other Middle Eastern countries) that have been dependent on oil as a source of wealth are heavily invested in nanotechnology. Are there any conclusions to be drawn from that?

Diversification is the name of the game. It is very dangerous for local or national economies to be dependent on a single sector, even when it is one as lucrative as oil & gas. We have done a lot of work in the Middle East, and the issue there is also one of employment. Most of the expertise for oil & gas is imported and in Gulf countries that have gone from fishing villages to major international cities within a generation there is a real need to provide employment for their youthful populations. Nanotechnology and life sciences are seen as industries of the future and are increasingly central to strategy in the Gulf.

Iran is a different case, and it’s a place I have visited several times to discuss nanotechnologies. While the world may have some issues with the Iranian government, the scientists and business people I deal with are just like the rest of us. Iran has some great science going on, and the US embargo has meant that they have had to be quite ingenious to get access to even basic instrumentation such as electron microscopes. However, there’s a large domestic market, and the Iranians are manufacturing everything from scientific instruments to nanomaterials. When the political issues are solved, I think a few people will be surprised by the level of sophistication of Iranian nanoscience. [Note: For an example of what Tim is referring to, see the Fast Company article (Using 3-D Printers To Mock Up New Teeth) by Morgan Glendaniel, as it mentions the impact that Iranian scientists have had on this new nano-enabled technology.)

(f) Is there anything that you couldn't include in the report but wanted to? For example, a country that doesn't register yet in terms of its spending or innovation quotient numbers but that you think is quietly gearing up.

Our dataset is very large, and this report is just the tip of the iceberg as we have clients who pay for the detailed information. As a result the published report just concentrates on the top level numbers for the major economies. There are a few places that really stand out though, such as Singapore. The science and technology infrastructure in Singapore is world class, but it is a small country with no real domestic market so the challenge will be commercialising the fruits of its nanotechnology projects. The current strategy is based on licensing to multinationals but that alone won't justify the investment so I suspect we will see a lot more partnering around the region, leveraging Singaporean technology in regional markets as, for example, SingTel has successfully done.

A real disappointment is India, with their leading Scientist, CNR Rao, being recently quoted as thinking that the country is in danger of missing the boat. [Note: You can find some of the quotes in this July 8, 2011 posting.]  I have spent large amounts of time in India and I know the raw talent is there, but the creaky infrastructure and lack of political will means that they are currently performing way below their potential.

(g) I will be asking a question or two about the Canada and nanotechnology from a global perspective but I’d like to learn a little bit about the project/workshop you delivered for the Canadian government some years ago. As I recall, it was an analysis of the Canadian effort at that point in time. And, are there any plans for future presentations in Canada?

We did some work for the NRC [National Research Council] a few years ago and also attended a few conferences in Canada in the early part of the decade [2000s] but since then I haven’t been back, although judging from the activity that is going on and looking at where Canada is on the rankings then maybe I should spend more time there!

(h) Generally, how would you describe Canada and its role in the global nanotechnology effort?

Our numbers indicate that it is a good place to be, similar to Australia, The Netherlands, Singapore and the Nordic economies, which is what you would expect.  The US, Russia and China are way out in front with huge funding programs, so the way to compete is obviously to be smarter and find niches rather than trying to cover every aspect of what is a huge field. Knowing where you want the economy to go and nurturing the technologies that will help you achieve that is always a good strategy. But governments are usually terrible at picking winners. Most politicians and civil servants are often ill equipped to advise people on how to run a business, so creating the right environment for innovation and then letting entrepreneurs get on with it is probably the best option.

(i) Are there any suggestions you’d make to Canadian policymakers as to improving Canada’s situation?

Think I just answered that above. ;) In a nutshell it’s not about how much; it’s about how effective the funding is.

(j) How much work is it to write a report like 2011 Global Funding of Nanotechnologies and Its Impact?

It is harder than it looks.  We have been collecting these numbers for the last 10 years but that’s only part of it. We also have to build and maintain relationships with a huge network of government agencies and scientists around the world so that we can understand which numbers are real.  A lot of governments are very happy to announce funding for nanotechnology, but that doesn’t actually mean that it is available and much of what what we try to do is confirm that all the funding we track is real cash and not just a political announcement.

(k) Is there anything you’d like to add?

After 12 years and almost $70 billion in funding we have to keep thinking about why we do science and how we can encourage its results to be translated into both economic and social well-being. The technology transfer process is very inefficient and the path is strewn with many obstacles. If this was a business process someone would have found a way to streamline it by now.

Thank you Tim Harper for going ‘over and above’ in answering my questions.

One final note, in addition to being a ‘serial tech entrepreneur’ (ETA July 18, 2011: I added the word tech to ‘serial entrepreneur’] and CEO (chief executive officer) of Cientifica, Tim co-owns a fashion boutique, Foxbat in the Spitalfields district of London, UK  (proving that people involved in nanotechnology have a broad set of interests).