Tag Archives: NCC

Nanocellulose and forest residues at Luleå University of Technology (Sweden)

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Swedish scientists have developed a new production technique which scales up the manufacture of cellulose nanfibres and cellulose nanocrystals (CNC, aka nanocrystalline cellulose [NCC]) from waste materials. From the Aug. 30,2013 news item on Nanowerk (Note: A link has been removed),

Luleå University of Technology is the first in Sweden with a new technology that scales up the production of nano-cellulose from forest residues. It may eventually give the forest industry profitable new products, e.g. nano-filters that can clean both the gases, industrial water and even drinking water. Better health and cleaner environment, both nationally and internationally, are some possible outcome

“There is large interest in this from industries, especially because our bionanofilters are expected to be of great importance for the purification of water all around the globe,” says Aji Mathew, Associate Professor at Luleå University of Technology, who leads the EU-funded project, NanoSelect.

The Luleå University of Technology Aug. 28, 2013 news release, which originated the news item, briefly describe the process and the magnitude of the increased production,

On Tuesday [Aug. 27, 2013], researchers at Luleå University of Technology demonstrated before representatives from the Industry and from research institutes how they have managed to scale up the process of manufacture of nano-cellulose of two different residues from the pulp industry. One is from Domsjö in Örnsköldsvik in the form of a fiber product that is grinded down to tiny nano fibers in a special machine. Through this process, the researchers have managed to increase the amount of the previous two kilograms per day to 15 kg per day. Another byproduct is nanocrystals that have been successfully scaled up from 50 to 640 grams / day. The process is possible to scale up and therefore highly interesting for the forest industry.

As noted in the news item, this development is an outcome of the EU- (European Union) funded NanoSelect project, from the Project Details webpage,

NanoSelect aims to design, develop and optimize novel bio-based foams/filters/membranes/adsorbent materials with high and specific selectivity using nanocellulose/nanochitin and combinations thereof for decentralized industrial and domestic water treatment. NanoSelect proposes a novel water purification approach combining the physical filtration process and
the adsorption process exploring the capability of the nanocellulose and/or nanochitin (with or without functionalization) to selectively adsorb, store and desorb contaminants from industrial water and drinking water while passing through a highly porous or permeable membrane.

As the news release notes,

Nano Filter for purification of process water and drinking water is not the only possible product made of nano-cellulose since cellulose has much greater potential.

– Large-scale production of nano-cellulose is necessary to meet a growing interest to use bio-based nanoparticles in a variety of products, says Kristiina Oksman professor at Luleå University of Technology.

Nano filters is today developed at Imperial College, London, in close collaboration with the researchers at Luleå University of Technology.

– We have optimized the process to produce nano filters, we can control the pore size and thus the filter porosity. It’s actually just a piece of paper and the beauty of this piece of paper is that it is stable in water, not like toilet paper that dissolves easily in water, but stable, says Professor Alexander Bismarck at Imperial College.

Nice to hear more about CNC developments.

Crystalline cellulose nanofibers and biomass fuel

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Perhaps one day the researchers who work with cellulose at the nanoscale will agree to some kind of terminology. Unfortunately, that day does not seem to be scheduled for the near future as per the latest research from Los Alamos National Laboratory and the Great Lakes Bioenergy Research Center (GLBRC) in the June 19, 2013 news item on ScienceDaily,

Improved methods for breaking down cellulose nanofibers are central to cost-effective biofuel production and the subject of new research from Los Alamos National Laboratory (LANL) and the Great Lakes Bioenergy Research Center (GLBRC). Scientists are investigating the unique properties of crystalline cellulose nanofibers to develop novel chemical pretreatments and designer enzymes for biofuel production from cellulosic — or non-food — plant derived biomass.

“Cellulose is laid out in plant cell walls as crystalline nanofibers, like steel reinforcements embedded in concrete columns,” says GLBRC’s Shishir Chundawat. “The key to cheaper biofuel production is to unravel these tightly packed nanofibers more efficiently into soluble sugars using fewer enzymes.”

The June 19, 2013 Los Alamos National Laboratory news release, which originated the news item, explains the new technique in more detail,

An article published this week in the Proceedings of the National Academy of Sciences suggests—counter-intuitively—that increased binding of enzymes to cellulose polymers doesn’t always lead to faster breakdown into simple sugars. In fact, Chundawat’s research team found that using novel biomass pretreatments to convert cellulose to a unique crystalline structure called cellulose III reduced native enzyme binding while increasing sugar yields by as much as five times.

…

The researchers had previously demonstrated that altering the crystal structure of native cellulose to cellulose III accelerates enzymatic deconstruction; however, the recent observation that cellulose III increased sugar yields with reduced levels of bound enzyme was unexpected. To explain this finding, Chundawat and a team of LANL researchers led by Gnana Gnanakaran and Anurag Sethi developed a mechanistic kinetic model indicating that the relationship between enzyme affinity for cellulose and catalytic efficiency is more complex than previously thought.

Cellulose III was found to have a less sticky surface that makes it harder for native enzymes to get stuck non-productively on it, unlike untreated cellulose surfaces. The model further predicts that the enhanced enzyme activity, despite reduced binding, is due to the relative ease with which enzymes are able to pull out individual cellulose III chains from the pretreated nanofiber surface and then break them apart into simple sugars.

“These findings are exciting because they may catalyze future development of novel engineered enzymes that are further tailored for conversion of cellulose III rich pretreated biomass to cheaper fuels and other useful compounds that are currently derived from non-renewable fossil fuels,” says Gnanakaran.

Here’s a link to and a citation for the published paper,

Increased enzyme binding to substrate is not necessary for more efficient cellulose hydrolysis by Dahai Gaoa, Shishir P. S. Chundawat, Anurag Sethic, Venkatesh Balana, S. Gnanakaranc, and Bruce E. Dalea. Published online before print June 19, 2013, doi: 10.1073/pnas.1213426110
PNAS June 19, 2013

There is open access to the article (I’m not sure if this is permanent or temporary).

As I hinted at the beginning of this piece, there are a number of terms used to describe cellulose at the nanoscale. For example, there’s nanocrystalline cellulose (NCC) which is also known as cellulose nanocrystals (CNC); this second term now seems to be preferred. My latest writing on nanocellulose, which seems to be a generic term covering all of the versions cellulose at the nanoscale is in a May 21, 2013 posting about some nanotoxicology studies and in a May 7, 2013 posting about a Saskatchewan-based (Canada) biorefinery (Blue Goose Biorefinery) and its production of CNC.

There are many more here on the topic and, if you’re interested, you may want to try CelluForce, FPInnovations, CNC, and/or NCC, as well as, nanocellulose or cellulose, as blog search terms.

Brazil, Canada, and an innovation, science, and technology forum in Vancouver (Canada)

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The Brazil-Canada Chamber of Commerce (BCCC) is presenting, in partnership with Simon Fraser University’s (SFU) Beedie School of Business, an all-morning forum on June 17, 2013. From the SFU Vancouver Events: June 14 – 21, 2013 announcement (Note: Links have been removed),

Monday, June 17 [2013]

Brazil-Canada Business, Innovation, Science, and Technology Forum

Time: 8-11:30am

Place: Segal Graduate Business School, 500 Granville St.

Cost: $35-70, register online

Join us for a morning focused on Business Innovation and Science & Tecnology opportunities in the Brazilian economy. The opening speakers, Ambassador Sergio Florencio, Consul General and Dr. Jeremy Hall will provide an overview of the landscape in Brazil. The panel discussion includes industry leaders who have piloted extensive business in Brazil specifically in the agriculture, mining and infrastructure fields: Marcelo Sarkis, Heenan Blaikie; Ray Castelli, Weatherhaven and Rogerio Tippe, Javelin Partners. If you are interested in conducting business in Brazil and would like to understand more about the dynamics of the Brazilian economy and how businesses operate, please register now.

If the event is about business, innovation, science, and technology, it seems curious the only mentions of science and/or technology in the event description are confined to a few of the panelists’ interests in agriculture, mining, and whatever they mean by infrastructure.

Brazil is one of the BRICS (Brazil, Russia,India, China, and South Africa) countries and, from what I understand, this very loose coalition is eager to take a leadership position vis à vis science, technology, and innovation supplanting the dominance of the US, Japan, and the European Union.

In the early 1990s, I wrote a paper about science and technology transfer and noted that Brazil was entering a new period of development after years of the country’s science and technology efforts (scientists) being isolated from the rest of the world in a failed  attempt to create a powerhouse international enterprise.

Some 20 years later, the decision to join the rest of the science and technology world seems to have been successful. Brazil is set to host the 2014 World Cup for soccer (or, as most of the world calls it, football) and the summer Olympics in 2016. (Sports are often correlated with science and technology advances.) I don’t believe any other country has ever attempted to host two such large international sports events within two years of each other. That’s a pretty confident attitude.

There are two areas of science and technology research in Brazil that are of particular interest to me, brain research and the work on cellulose nanocrystals (CNC), also known as, nanocrystalline cellulose (NCC).

While the focus was on Miguel Nicolelis and Duke University (US), the recent announcement of brain-to-brain communication via the Internet featured a research facility in Brazil (from my Mar. 4, 2013 posting),

Miguel Nicolelis, a professor at Duke University, has been making international headlines lately with two brain projects. The first one about implanting a brain chip that allows rats to perceive infrared light was mentioned in my Feb. 15, 2013 posting. The latest project is a brain-to-brain (rats) communication project as per a Feb. 28, 2013 news release on *EurekAlert,

Researchers have electronically linked the brains of pairs of rats for the first time, enabling them to communicate directly to solve simple behavioral puzzles. A further test of this work successfully linked the brains of two animals thousands of miles apart—one in Durham, N.C., and one in Natal, Brazil.

The results of these projects suggest the future potential for linking multiple brains to form what the research team is calling an “organic computer,” which could allow sharing of motor and sensory information among groups of animals. The study was published Feb. 28, 2013, in the journal Scientific Reports.

“Our previous studies with brain-machine interfaces had convinced us that the rat brain was much more plastic than we had previously thought,” said Miguel Nicolelis, M.D., PhD, lead author of the publication and professor of neurobiology at Duke University School of Medicine. “In those experiments, the rat brain was able to adapt easily to accept input from devices outside the body and even learn how to process invisible infrared light generated by an artificial sensor. So, the question we asked was, ‘if the brain could assimilate signals from artificial sensors, could it also assimilate information input from sensors from a different body?’”

One of Nicolelis’s other goals is to have someone with quadriplegia kick the opening ball for the Brazil-hosted 2014 World Cup (Walk Again Project). From my Mar. 16, 2012 posting,

It is the exoskeleton described on the Walk Again Project home page that Nicolelis is hoping will enable a young Brazilian quadriplegic to deliver the opening kick for the 2014 World Cup (soccer/football) in Brazil.

Moving on to the other area of interest, CNC research , which in Canada is discussed in terms of the forestry industry (I’ve blogged about this extensively, the search term NCC should fetch most if not all of my postings on the topic), is taking a different tack in Brazil where the focus is on pineapple and banana fibres. My Mar. 28, 20111 posting (Nanocellulose fibres, pineapples, bananas, and cars) focuses on cellulose and plastic,

Brazilian researchers are working on ways to use nanocellulose fibres from various plants to reinforce plastics in the automotive industry. From the March 28, 2011 news item on Nanowerk,

Study leader Alcides Leão, Ph.D., said the fibers used to reinforce the new plastics may come from delicate fruits like bananas and pineapples, but they are super strong. Some of these so-called nano-cellulose fibers are almost as stiff as Kevlar, the renowned super-strong material used in armor and bulletproof vests. Unlike Kevlar and other traditional plastics, which are made from petroleum or natural gas, nano-cellulose fibers are completely renewable.

My second and, to date, only other posting (June 16, 2011) about the work in Brazil features a transcript of an interview with CNC researcher, Alcides Leão.

Finally, I have a few factoids which I will tie together, loosely, and try to show how they relate to this forum. First, São Paulo, Brazil hosts the world’s second oldest and one of its most important biennial visual arts events. (BTW, the next one, Bienal de São Paulo,  is in 2014.) Second, the recent Council of Canadian Academies assessment, State of Science and Technology in Canada, 2012, stated that Canada rates very highly in six areas, one of those areas being the Visual and Performing Arts. Admittedly Canada’s prominence in the visual and performing is fueled largely by efforts in Québec (as per the assessment), still, one would think there might be some value in trying to include that sector in this  forum and encourage the local visual and performing arts technology industry to make connections with the Brazilian industry.

Finally for those of you who have persisted, here’s the link to buy tickets for the June 17, 2012 forum.

ETA June 21, 2013: The protests in Brazil have attracted worldwide attention and according to a June 21,2013 posting by Dillon Rand on Salon.com there are: 5 signs Brazil’s’ not ready to host the World Cup.

Blue Goose Biorefineries scales up production of cellulose nanocrystals (CNC) and more

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I last mentioned Saskatchewan’s (Canada) Blue Goose Biorefineries in a Jan. 22, 2013 posting about its activities with regard to cellulose nanocrystals. I’m a little late to the party but there’s an Apr. 11, 2013 news release on the Advanced Foods and Materials website which notes that Blue Goose Biorefineries’ production of cellulose nanocrystals (CNC also sometimes known as nanocrystalline cellulose, NCC) has been scaled up,

Advanced Foods and Materials (AFM) Canada and Blue Goose Biorefineries Inc. (BGB), are pleased to announce the successful scale up of biorefining technology for the production of high value microcrystalline cellulose (MCC), cellulose nanocrystals (CNC), lignin, and green platform chemicals from flax and hemp straw.

In collaboration with the University of Saskatchewan’s College of Agriculture and Bioresources Bioprocessing Pilot Plant, and POS Bio-Sciences, BGB’s proprietary Renewable Residuals RefiningTM (R3TM) biorefining technology was successfully scaled up to process 100 kg of pulp in a reaction volume of 2500L to produce microcrystalline cellulose and cellulose nanocrystals of high purity, along with lignin and green platform chemicals as by-products. Throughout this process, the technology has shown promising advantages over existing biorefining methods including cost, yield, environmental impact, and flexibility. Necessary process steps demonstrated include biomass preparation, dewatering and washing, reaction mixing and crystalline cellulose washing. The project also successfully demonstrated the spray drying of the cellulose crystals at POS Bio-Sciences.

It’s exciting to hear that there might be more production of CNC in Canada, as well as, microcrystalline cellulose, lignin, and other by-products,. It seems where CNC is concerned that demand exceeds supply (I get the occasional query from someone trying to find a supplier).

I have more information about Advanced Foods and Materials Canada in my Jan. 22, 2013 posting. As well, here are links to the POS Bio-Sciences website and more information about the University of Saskatchewan’s Bioprocessing Pilot Plant.

ETA May 7, 2013 4:30 pm PDT: Dr. Bernard Laarveld of Blue Goose Biorefineries (BGB) very kindly noted this in an email to me today,

… we are now planning to develop a pilot plant for the production of NCC (aka CNC) and MCC and are raising the funding. This development through BGB is more driven from the private sector in partnership with Advanced Food Materials Canada.  We intend to process about 500 kg  of flax or hemp straw per day, and this would generate about 250 kg per day of crystalline cellulose. BGB has an advantage through low cost of production.

Very exciting news and I wish the Dr. Laarveld and the folks at BGB all the best.

Solar cells made even more leaflike with inclusion of nanocellulose fibers

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Researchers at the US Georgia  Institute of Technology (Georgia Tech)  and Purdue University (Indiana) have used cellulose nanocrystals (CNC), which is also known as nanocrystalline cellulose (NCC), to create solar cells that have greater efficiency and can be recycled. From the Mar. 26, 2013 news item on Nanowerk,

Georgia Institute of Technology and Purdue University researchers have developed efficient solar cells using natural substrates derived from plants such as trees. Just as importantly, by fabricating them on cellulose nanocrystal (CNC) substrates, the solar cells can be quickly recycled in water at the end of their lifecycle.

The Georgia Tech Mar. 25, 2013 news release, which originated the news item,

The researchers report that the organic solar cells reach a power conversion efficiency of 2.7 percent, an unprecedented figure for cells on substrates derived from renewable raw materials. The CNC substrates on which the solar cells are fabricated are optically transparent, enabling light to pass through them before being absorbed by a very thin layer of an organic semiconductor. During the recycling process, the solar cells are simply immersed in water at room temperature. Within only minutes, the CNC substrate dissolves and the solar cell can be separated easily into its major components.

Georgia Tech College of Engineering Professor Bernard Kippelen led the study and says his team’s project opens the door for a truly recyclable, sustainable and renewable solar cell technology.

“The development and performance of organic substrates in solar technology continues to improve, providing engineers with a good indication of future applications,” said Kippelen, who is also the director of Georgia Tech’s Center for Organic Photonics and Electronics (COPE). “But organic solar cells must be recyclable. Otherwise we are simply solving one problem, less dependence on fossil fuels, while creating another, a technology that produces energy from renewable sources but is not disposable at the end of its lifecycle.”

To date, organic solar cells have been typically fabricated on glass or plastic. Neither is easily recyclable, and petroleum-based substrates are not very eco-friendly. For instance, if cells fabricated on glass were to break during manufacturing or installation, the useless materials would be difficult to dispose of. Paper substrates are better for the environment, but have shown limited performance because of high surface roughness or porosity. However, cellulose nanomaterials made from wood are green, renewable and sustainable. The substrates have a low surface roughness of only about two nanometers.

“Our next steps will be to work toward improving the power conversion efficiency over 10 percent, levels similar to solar cells fabricated on glass or petroleum-based substrates,” said Kippelen. The group plans to achieve this by optimizing the optical properties of the solar cell’s electrode.

The news release also notes the impact that using cellulose nanomaterials could have economically,

There’s also another positive impact of using natural products to create cellulose nanomaterials. The nation’s forest product industry projects that tens of millions of tons of them could be produced once large-scale production begins, potentially in the next five years.

One might almost  suspect that the forest products industry is experiencing financial difficulty.

The researchers’ paper was published by Scientific Reports, an open access journal from the Nature Publishing Group,

Recyclable organic solar cells on cellulose nanocrystal substrates by Yinhua Zhou, Canek Fuentes-Hernandez, Talha M. Khan, Jen-Chieh Liu, James Hsu, Jae Won Shim, Amir Dindar, Jeffrey P. Youngblood, Robert J. Moon, & Bernard Kippelen. Scientific Reports  3, Article number: 1536  doi:10.1038/srep01536 Published 25 March 2013

In closing, the news release notes that a provisional patent has been filed at the US Patent Office.And one final note, I have previously commented on how confusing the reported power conversion rates are. You’ll find a recent comment in my Mar. 8, 2013 posting about Ted Sargent’s work with colloidal quantum dots and solar cells.

Waterloo Institute of Nanotechnology/EcoSynthetix industrial partnership and an interlaced relationship

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The EcoSynthetix and Waterloo Institute for Nanotechnology partnership announced today (Mar. 13, 2013) is an example of how tightly interlaced the relationships between academic institutions and their graduates’ start-up companies can be. A Mar. 13, 2013 news item on Nanowerk describes the partnership,

EcoSynthetix Inc. and the Waterloo Institute for Nanotechnology at the University of Waterloo have joined forces through an industrial partnership to collaborate on new applications for EcoSynthetix’ EcoSphere® technology. The five-year agreement will be jointly funded through an EcoSynthetix and NSERC (National Sciences and Engineering Research Council) Collaborative Research and Development Grant. The project matches the scientific expertise from the University of Waterloo in macromolecular science with the sustainability benefits of EcoSphere® bio-based nanoparticles which are based on green chemistry. The goal of the project is to broaden the scientific knowledge base of the EcoSphere® technology to support its introduction into new application areas.

The Mar. 13, 2013 EcoSynthetix news release, which originated the news item, mentions the relationship in passing while extolling the virtues of the partnership,

“As a global centre of excellence for nanotechnology research, this project represents a great opportunity for our institute, faculty and students at the University, to collaborate with a local innovator to further our understanding of the technology and its potential applications,” said Dr. Arthur J. Carty, Executive Director of the Waterloo Institute for Nanotechnology (“WIN”) and an independent director of the board of EcoSynthetix. [emphasis mine] “Nanotechnology is a leading-edge, enabling technology that holds the promise of a lasting economic benefit for jobs and investment in the materials, energy and healthcare sectors. EcoSynthetix’s innovative nanotechnology has the potential to impact a wide-array of markets that would benefit from a sustainable alternative to petroleum-based products.”

“This ECO-WIN collaboration involves four professors and eight graduate students at the Waterloo Institute for Nanotechnology and is a great example of how industry and universities can work together to advance an exciting new area of science to benefit the community,” said Dr. Steven Bloembergen, Executive Vice President, Technology of EcoSynthetix. “Our EcoSphere® technology is already commercial and providing sustainable benefits in three separate markets today. Our team’s primary focus at this stage is near-term product development and product enhancements of carbohydrate-based biopolymers. By working with the Institute of Nanotechnology to deepen our understanding of the basic science, we can identify new future applications that could benefit from our sustainable biobased materials.”

The EcoSphere® technology is being commercially utilized as biobased latex products providing alternatives to petroleum-based binders in the coated paper and paperboard market. [emphasis mine] The goal of this project is to generate a greater understanding of the properties of EcoSphere® biolatex® binders by establishing a knowledge base that could enable tailor-made novel particles with the desired properties for a given application. The project team will be chemically modifying the nanoparticles and then characterizing how the properties of the novel particles are affected by these changes.

I don’t understand what “independent director” means in this context. Is the term meant to suggest that it’s a coincidence Carty is WIN’s executive director and a member of the EcoSynthetix board? Or, does it mean that he’s not employed by the company? If any readers care to clarify the matter, please do leave a comment. In any event, the EcoSynthetix timeline suggests the company has a close relationship with the University of Waterloo as it was founded in 1996 by graduates  (from the company’s About Us History Timeline webpage),

EcosynthetixTimeline

As for the product line which birthed this partnership, there’s a disappointing lack of technical detail about Ecosphere biolatex binders. Here’s the best I can find on the company website (from the Ecosphere Biolatex Binders Performance page),

The smaller particle size characteristic of biolatex binders results in increased binder strength and performance. In coated paper, it provides improved aesthetics; a rich, bright finish; enhanced open structure and excellent printability across all grades.

I wonder if some of this new work will be focused on ways to use CNC (cellulose nanocrytals or NCC, nanocrystalline cellulose) in addition to the company’s previously developed “bio-based nanoparticles”  to enhance the product which, as I highlighted earlier, sells to the “coated paper and paperboard market.” From the CelluForce (the CNC/NCC production plant in Quebec) Applications page,

NCC’s properties and many potential forms enable many uses, including:

  • Biocomposites for bone replacement and tooth repair
  • Pharmaceuticals and drug delivery
  • Additives for foods and cosmetics
  • Improved paper and building products
  • Advanced or “intelligent” packaging
  • High-strength spun fibres and textiles
  • Additives for coatings, paints, lacquers and adhesives
  • Reinforced polymers and innovative bioplastics
  • Advanced reinforced composite materials
  • Recyclable interior and structural components for the transportation industry
  • Aerospace and transportation structures
  • Iridescent and protective films
  • Films for optical switching
  • Pigments and inks
  • Electronic paper printers
  • Innovative coatings and new fillers for papermaking

Since I’m already speculating, I will note I’ve had a couple of requests for information on how to access NCC/CNC from entrepreneurs who’ve not been successful at obtaining the material from the few existing production plants such as CelluForce and the one in the US. It seems only academics can get access.

One last comment about this ‘partnership’, I’d dearly love to know what relationships, if any exist, between the proponents and the NSERC committee which approved the funding.

Interestingly, Carty is the chair for the recently convened expert panel for the Council of Canadian Academies’ The State of Canada’s Science Culture assessment, as per my Dec. 19, 2012 post about the announcement of his appointment. This latest development casts a new light on the panel (my Feb. 22, 2013 post notes my reaction to the expert panel’s membership) and the meaning of science culture in Canada.

Sanofi BioGENEius Challenge Canada celebrates 20 years

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The first time (May 11, 2012 posting) I wrote about the Sanofi BioGENEius Challenge Canada (SBCC) competition was when Janelle Tam was recognized as the 2012 national winner for her work with nanocrystalline cellulose (NCC) or, as it is sometimes known, cellulose nanocrystals (CNC).  As I noted then,

For anyone who’s curious about Sanofi, it’s a French multinational pharmaceutical company headquartered in Paris, France. I found the Wikipedia essay a little more informative than the Sanofi company website .

Justifiably proud not only of Tam and other 2012 winners, SBCC has sent out a news release enumerating the many triumphs and benefits associated with this competition. From the SBCC Feb.20, 2012 news release,

Unexpected bonus prizes from a high school bioscience competition, mentored by some of Canada’s top research experts, range from six-figure scholarships, valuable networks and commercial patents to peer-reviewed journal citations, global publicity, international conference invitations and more, former teen participants say.

But the reward cited most often by alumni of the “Sanofi BioGENEius Challenge Canada” (SBCC), this year marking its 20th annual competition, is the eye-opening experience of watching their inventive ideas succeed and being encouraged in a professional lab, creating in many a career-shaping passion for science.

“That’s a benefit shared throughout Canada’s economy, which has a growing, $86 billion biotechnology sector, as well as with people worldwide,” says Jeff Graham, Chair of the Board at the Toronto-based Bioscience Education Canada, which manages the SBCC program.

“This program has been ‘infecting’ teens with what one mentor calls the ‘research virus’ and inspiring bioscience careers since 1994. And with hundreds of dedicated partner organizations and mentors nation-wide, we are extremely proud of the success achieved so far as we mark the 20th annual SBCC.

The competition’s latest surprise bonus prize winners are 2012 national competitors Jeanny Yao, 18, and Miranda Wang, 19 of Vancouver, both now in first year at universities in Toronto and Montreal respectively.  The pair will spend Feb. 27 in Long Beach California, invited by organizers of the prestigious TED 2013 conference to tell the world’s science elite how they identified a species of bacteria from the Fraser River’s muddy banks that helps decompose plastic.

Their BC regional SBCC-winning project came to public attention last May in a front page story by the Vancouver Sun (http://bit.ly/XrsaB9)  as the duo were packing to attend SBCC’s national finals in Ottawa.  In the white marble halls of National Research Council of Canada headquarters — the country’s science temple — SBCC’s high-level final judging panel recognised Jeanny and Miranda’s project with a special prize for the “greatest commercial potential.”  (The girls have since approached firms in BC and Ontario on commercialisation ideas.)

They were invited last summer to present their project again at TED@Vancouver (http://bit.ly/X5PRAF), part of a “worldwide talent search,” and were among a handful picked from 293 entrants to reprise their presentation in California.

TED is widely considered the world’s marquee annual science show-and-tell.  And sharing a stage with fellow speakers like U2’s lead singer Bono and PayPal Founder Peter Theil is a five exclamation mark adventure for a couple of university frosh.

“We are extremely excited about this opportunity…!! We couldn’t have done this without your help!!!” Miranda wrote, announcing the news to SBCC’s Vancouver coordinators, LifeSciences BC.  (For more on Jeanny and Miranda at TED: http://bit.ly/WRAs45).

According to the news release some 4500 Canadian teenagers have participated in the competition since 1994. There was a survey of 375 participants, from the news release,

In a survey of 375 past participants by Bioscience Education Canada [BEC], which runs SBCC, 84% said their participation helped determine their field of study or career plan; 74% were pursuing biotechnology-related education or professions, with 12.5% undecided.  Some 55% were current university students, 24% planned to apply after high school, and 21% were post-secondary graduates now in the workforce.  Nearly 60% of respondents were female and 79% had or have bursaries and/or scholarships.

Typical of comments teens relayed with the survey replies, from Brooke Drover of Vernon River, PEI: “It was amazing. So unbelievably stressful, but when my team came second place I could hardly breathe. It was the best feeling in the world knowing that I didn’t just play a sport and win a trophy. I helped the scientific community.”

“Thanks to hundreds of top scientist mentors who have shared their expertise and lab space with the student competitors, we’ve discovered and nurtured incredible talent in high schools and CEGEP classrooms nation-wide,” says Rick Levick, Executive Director of BEC and head of the national competition since its inception,

“The mentors are the unsung heroes of the SBCC program. They often bring out a passion for science and talent for research in kids who didn’t know they had any.”

While I do have some questions about the survey (when was it administered? how was it administered? why 375? etc.), I’m letting them go in appreciation of the participants’ extraordinary accomplishments, from the news release,

Ottawa

Maria Merziotis, $5,000 first place winner in the national 2008 SBCC, found her prize included an academic fast track.  At 21, when those her age at university typically complete an undergrad degree, she’s finishing second year at the University of Ottawa’s medical school, with papers about her flu-related research in preparation for academic publication.

And, just seven years after he first impressed SBCC’s august panel of national judges as a Grade 11 student, Ottawa’s James MacLeod, now 23, is completing a Queen’s University master’s degree in pathology and molecular medicine and applying for early acceptance into the department’s PhD program.

Both credit SBCC with helping them reach medical career doors unusually soon.  Says Maria: “The SBCC competition is the main reason I stand where I am today.  It allowed me to explore the field of research, and through the doors it opened, gained me early acceptance into medical school.”

Saskatchewan

Says Rui Song of Saskatoon, who in Grade 9, age 14 (a veteran of Saskatchewan’s unique SBCC program for kids in Grades 7 and 8) prevailed over much older teens to win the #1 national award in 2010: “Before the SBCC, I hadn’t even considered being a researcher. I now hope to continue my research journey in university and in my career to continue creating beneficial change in the world.”

Her 2010 work to genetically fingerprint a lentil crop-killing fungus left the expert national judges “astonished.”  She also placed 2nd in last year’s national competition, accepted an offer to spend last summer doing research at Harvard, and today, in Grade 12, is weighing full-time university offers.

Southwestern Ontario

The 2012 top national winner, Janelle Tam of Waterloo, says “SBCC was a huge part of why I started laboratory research at the university in high school, which was instrumental in my decision that I want to be a professor.”

Janelle, completing Grade 12 with studies at Princeton University ahead this fall, detailed the anti-ageing potential of a nano compound found in wood pulp, capturing media attention in at least 36 countries (http://bit.ly/XduBJd), including a social media blog by then-Ontario Premier Dalton McGuinty (http://bit.ly/THiq7P).  Last summer in Québec she detailed her findings to staff and researchers of CelluForce’s, Domtar Corp. and FPInnovations — Canadian firms leading the commercial development of nanocrystalline cellulose.

Newfoundland

At 17, Sarai Hamodat of St John’s, Newfoundland, entered a prize-winning SBCC project  showing that a traditional Asian oil remedy could ease the suffering of asthma patients, a project inspired by her hope of helping her asthmatic uncle.

Says Sarai, now 23 and a medical resident in pharmacology at the Queen Elizabeth II Health Sciences Centre in Halifax: “SBCC was my first real introduction to what the world of science has to offer.”

British Columbia

Taneille Johnson entered the competition in 2009 from Fort St. John (pop. 22,000) near the Alberta border in northern BC.  At 16, she lived alone for a summer to work with a University of Calgary mentor in a quest to decipher DNA mutations that may lie behind a rare disorder which causes early onset aging and progressive bone marrow failure.

Taneille, the first student from northern BC to enter the regional event, won it in 2010 and placed third overall at the national finals in Ottawa.  Now 20, she’s a second year BSc student of immunology at McGill University, Montreal, with a goal of medical school studies at the University of British Columbia.

“Not many first year university science students can approach their professor and show them the amount of lab experience I had from the SBCC,” she says, adding “I really cannot overstate how unique the SBCC experience is for high school students.”

Greater Toronto

A year after his first place national win in the 2011 SBCC, Toronto’s Marshall Zhang faced a tough decision: offers from three of the world’s most prestigious Ivy League universities — Yale, Harvard and Princeton.

“The SBCC changed the course of my life,” says Marshall, now a Harvard freshman, who at age 16, and mentored at the Hospital for Sick Kids, used a powerful supercomputer cluster to create a potential new treatment for cystic fibrosis.

On CBC’s “The Nature of Things,” host Dr. David Suzuki cited Marshall and his ideas as an example of the marvels of uninhibited teenage thinking.  CF patients and their parents from across Canada and elsewhere wrote or called out of the blue to congratulate and thank Marshall for his efforts on their behalf.  He was in Grade 11.

“I’d never met a CF patient before then,” he says, adding that the most memorable part of the entire adventure was realizing the real impact his research could have on people.

Manitoba

At 17, Ted Paranjothy of Winnipeg, inspired by a memory from five years old of a friend who died from leukemia, invested 3,000 research hours over two years after school with a mentor at the University of Manitoba, developing innovative ideas for cancer treatment.  Ted’s framework for an anti-cancer agent able to kill human cancer cells without harming healthy ones is an innovation on which he now holds a patent.

His Grade 12 project earned a triple crown of high school biotech science: a first place sweep of the 2007 SBCC regional and national competitions, as well as the Sanofi-sponsored International BioGENEius Challenge — the only Canadian to achieve that distinction so far.  The three first prize cheques totaled $15,000.

Later awarded some $150,000 in scholarships from other sources, Ted continued work with his distinguished mentor, Dr. Marek Los, and had three papers in peer-reviewed journals by the end of first year at UofM.  Now 22, Ted is an independent researcher in cell science at UofM.  He credits SBCC with enabling his university graduate-level research while still in high school, and says it “inspired me to pursue a career in biomedical research.”

Quebec

In 2011, a trio of Montreal CEGEP students entered the national SBCC with their new sorbet for vegetarians, having discovered a substitute for animal-based gelatine normally found in the frozen dessert.  They won 2nd prize overall, a special award for that year’s project with the greatest commercial potential, and a lot of public attention, which helped create connections with several patent lawyers.

Today, all three are at universities studying science.  “The SBCC definitely pushed to me to explore research opportunities in medicine,” says one team member, Simon Leclerc, adding that feedback from top scientists who evaluated their project and the experience gained was “inestimable… The SBCC is of great help for young, otherwise non-connected students to push their projects forward.”

Brava! Bravo!

Applications for the 2013 competition have been closed since November 2012 but there is a listing of the times and dates for the regional and national 2013 competitions. Although it’s unclear to me whether or not the public is invited to attend, you can get more details here.

The race to commercialize graphene as per the University of Manchester (UK)

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The University of Manchester (UK) has a particular interest in graphene as the material was isolated by future Nobel Prize winners, Andre Gheim and Kostya (Konstantin) Novoselov in the university’s laboratories. There’s a Feb. 18, 2013 news item on Nanowerk highlighting the university’s past and future role in the development of graphene on the heels of the recent research bonanza,

The European Commission has announced that it is providing 1bn euros over 10 years for research and development into graphene – the ‘wonder material’ isolated at The University of Manchester by Nobel Prize winners Professors Andre Geim and Kostya Novoselov.

The University is very active in technology transfer and has an excellent track-record of spinning out technology, but some think that the University has taken a different view when it comes to patenting and commercialising graphene. Others have expressed a broader concern about British Industry lagging behind in the graphene ‘race’, based upon international ‘league tables’ of numbers of graphene patents.

A recent interview with Clive Rowland (CEO of the University’s Innovation Group) addresses the assumptions about the University’s approach and reflects more generally about graphene patenting and about industry up-take of graphene. The interview is summarised below.

Question: Has the University set up any commercial graphene activities?

Answer: The University owns a company, called 2-DTech Limited, which makes and supplies two-dimensional materials and has an interest in another, Graphene Industries Limited, which sells graphene made by a different technique to 2-DTech.

Question: Is the University falling behind in graphene?

Answer: The University is the world’s leading university for graphene research and publications. It led the charge for UK investment into the field and has been awarded The National Graphene Institute, which will be a £61m state-of-the art centre. This Institute will act as a focus for all sorts of commercial graphene activity in Manchester, from industrial research and development laboratories locating “alongside” the Institute, developing new processes and products, to start-up companies. The University championed the major flagship research funding programmes that have been initiated in the UK and Europe and has been awarded a number of prestigious grants. Graphene is still a science-driven research field and not yet a commercialised technology.

The rest of the summary can be found either at Nanowerk or in this University of Manchester Feb. 18, 2013 news release.

The University of Manchester Innovation Group (aka UMI3) mentioned in connection with Clive Rowland hosts the complete interview (12 pp), which, read from the beginning, provides an enhanced perspective on the university’s graphene commercialization goals,

Graphene – The University of Manchester and Intellectual Property. Dan Cochlin talks to Clive Rowland – The University’s InnovationGroup CEO —‐ about the launch of a new grapheme company at the University, 2–‐DTech Ltd, And grapheme patents and commercialisation.

What is grapheme and why is there so much interest in it?

Graphene is a revolutionary nano material which was first isolated at The University of Manchester By Professors Andre Geim And Konstantin Novoselov. They received the Nobel Prize in 2010 For their ingenious work on graphene. People are excited about it because it has the potential to transform a vast range of products due to its very superior capabilities compared to existing materials.

So what’s the new company about?

It makes and sells CVD graphene, grapheme platelets, grapheme oxide and other advanced materials with amazing properties, which are being called 2–‐D – two dimensional – due to  their single atomic layer thickness. In other words, they’re so thin it’s as if they only have length and breadth dimensions. It will soon have an e–‐commerce site too, where customers can shop on–‐line. The Company will create and develop intellectual property, especially by engaging in interesting assignments such as collaborating with firms on design projects. It will also provide consulting services ,in the field, either directly or by sub–‐contracting to our relevant academic colleagues here at the University. We’re already an international team – with Antiguan, British and Italian people actively involved in the business and a fast developing business agency network in the Far East and the USA.

What’s CVD?

It’s one of the techniques for making grapheme that 2-DTech uses –‐ chemical vapour deposition –‐ which allows us to grow grapheme on foils and films in quite large area sizes for various potential uses, particularly information technology and communications because of graphene’s high quality and unique electronic transport, flexibility and other astounding attributes.

Well why have you only just set this up when others have been doing so for a while now?

The University’s researchers in physics and materials science have been able to make enough grapheme for their own needs until lately, but not any longer. Besides, there has been an expansion of interest across the University in the potential of the material, including from areas such as health and bio–‐sciences. Hence we want to make sure that the University has a regular supply for those colleagues who cannot continue to make it in sufficient quantities or who aren’t familiar with the material.

In addition many of the companies in contact with the University’s Researchers are in a similarly constrained position. So we feel the need to have a University Facility to handle this which is free of the normal academic duties and interests. At the same time we see an international business opportunity.

There’s a strong market demand for high quality grapheme of a consistent nature and a growing interest in other 2–‐D crystals. A number of researchers, especially our CTO Dr Branson Belle, who had been researching 2–‐D Materials and making grapheme for a long time became interested in the business side. …

Thank you Clive Rowland and the University of Manchester for insight into the graphene commercialization efforts on the part of at least one university.  Meanwhile, the comment about producing enough graphene for research reminds me of the queries I get from entrepreneurs about getting access to nanocrystalline cellulose (NCC) or cellulose nanocrystals (CNC). To my knowledge, no one outside the research community has gotten access to the materials. I wonder if despite the fact there are two manufacturing facilities whether this may be due to an inability to produce enough CNC or NCC.

Saskatchewan’s Blue Goose Biorefineries and cellulose at the nanoscale and microscale

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Thank you to the reader who put me onto this Saskatchewan-based company that claims to produce nanoscale (sometimes called nanocrystalline cellulose [NCC] or nanocellulose crystals [CNC]) and microscale cellulose in an environmentally friendly fashion. From the Blue Goose Biorefineries’ home page,

BLUE GOOSE BIOREFINERIES INC. TM

Blue Goose Biorefineries Inc. introduces the R3TM (Renewable Residual Refining) technology and process to the Canadian marketplace.  R3TM is the world’s most advanced process and technology for the conversion of  carbon-based biomass into high-value, in-demand market commodities

 Economical, Sustainable, Efficient, Benign

 The Patent-Pending technology and process, together with closely held trade secrets, have created an entirely new, efficient and economically viable perspective on the treatment of biomass for the production of high value-added, sustainable and renewable commodities and energy sources.

 Microcrystalline Cellulose, Nanocrystalline Cellulose, Green Platform Chemicals

 Blue Goose Biorefineries Inc. is a Canadian innovation leader resolving environmental issues and generating economic opportunities through innovative, green, and renewable materials manufactured by our unique process and technology.

There doesn’t seem to be any information about the company’s management team, its products, or its technologies on its website. As well, the Blue Goose website does not host any press releases relating to company developments and/or business deals but there is a July 20, 2012 notice on the Advanced Foods and Materials (AFM) Canada website about a joint project,

Advanced Foods and Materials (AFM) Canada and Blue Goose Biorefineries Inc. (BGB) are pleased to announce they have been awarded a $500,000 grant from Agriculture and Agri-Food Canada’s Agricultural Innovation Program. The project will focus on the pre-commercialization and development of biorefining methods for flax and hemp straw in order to produce high value cellulose products, lignin, and green platform chemicals in Saskatchewan. BGB’s core technology is a “green chemistry” based, nano-catalytic biorefining process, Renewable Residuals RefiningTM (R3TM).  The R3TM process fractionates and breaks down the major components in lignocellulosic biomass: lignin, hemicellulose and cellulose. This green technology offers many process advantages over existing biorefining methods including cost, yield, environmental impact, and flexibility. Specifically, the technology offers a very strong industry transforming potential for the production of high value microcrystalline cellulose (MCC), nanocrystalline cellulose (NCC), lignin and green platform chemicals from flax and hemp straw.

The process has been proven at the lab bench scale for flax and hemp straw. Through this project, Advanced Foods and Materials Canada will manage institutional research activities and the pilot plant scale-up of the biorefining process. The production of larger quantities of bioproducts for testing, process development and lock-down including design parameters, engineering costs and tuning, will facilitate the development of a demonstration plant for Blue Goose Biorefineries. The impact of this project’s activities will add-value to Canadian hemp, flax and other cereal crops by creating a more efficient and economical source of high-quality MCC, NCC, lignin, and green platform chemicals for food, pharmaceutical, and industrial applications across North America.

Agriculture and Agri-Food Canada’s July 18, 2012 news release can be read here.

There is one other piece of information, Dr. Bernard Laarveld of the University of Saskatchewan lists Blue Goose Biorefineries as a current employer on his LinkedIn profile.

http://www.afmcanada.ca/event/BGBAIP

Central Saint Martins College of Art and Design and their Nano4Design workshop

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A Jan. 12, 2013 news item on Nanowerk highlights some of the projects and materials presented at the Nov. 29, 2012 Nano4Design workshop held at Saint Martins College of Art and Design. But first, here’s more about the workshop before it was presented, from the workshop description on the IOM3 (Institute of Materials, Minerals, and Mining) website,

Sustainability is now a key driver in product design. Sustainability includes: reducing environmentally harmful emissions during processing, avoiding the use of toxic and scarce resources, using  sustainable materials, designing-in recyclability and re-use, and environmental remediation such as carbon capture.

Sponsored by and hosted at Central Saint Martins College of Arts and Design, this workshop is a must-attend for all product designers looking for new sustainable technologies – a unique opportunity to hear new ideas, network with peers and meet technology providers.

This workshop is for designers, materials scientists, and engineers developing or looking for  sustainable solutions in product design. Application markets are diverse, from architecture to cars, aircraft to fashion, and electronic devices to alternative technology.

Speakers include:

• Harnessing Nanotechnology to Combat Climate Change for the Built Environment – Carole Collet, Textile Futures Research Centre, Central St Martins

• Inkjet Printing for Novel Solar Control – Brian Hughes, Solaveil

• Plastic Electronics for Tagging, Sensing and Energy – Richard Kirk, Polyphotonics

• Nanocellulose – A Sustainable Alternative – Prof Mizi Fan, Brunel University

• Novel Materials for Thermal Control – Zafer Ure, PCM Products

• Surface Regeneration for Buildings – Alessia Giardino, Textile & Surface Designer

• TSB Funding Call “New Designs for a Circular Economy” – John Whittall, Technology Strategy Board

The news item on Nanowerk provides more information about specific materials and projects discussed at Nano4Design,

Iceclay

An alternative nanostructured clay aerogel that is cost-effective and ultra- lightweight is being developed through an EU consortium. The ICECLAY project aims to enhance the competitiveness of SMEs by creating a new generation of low-cost and efficient insulation materials for the EU building construction industry.

Pros: The production of the material and its integrated composites will use water and eco-friendly or soluble/dispersible low-cost polymers and a cost-effective freeze-drying process. The ICECLAY material has a highly porous structure and reduced thickness.

Application: The thermal insulation material is designed for highly energy efficient buildings, retrofit and advanced HAVC systems.

Thin and flexible lightweight ICECLAY boards or films could also offer a cheaper alternative to high-performance insulation materials such as the supercritical-dried silica aerogel. The powderbased ICECLAY will be used as thermal insulation fillers for a broad range of building products, including concrete, drywalls, bricks, plaster and coatings.

The project will be completed in 2014. If you are interested in taking part in the ongoing group, visit the ICECLAY project website.

…

Nanocellulose hemp fibres

The Forest Products Laboratory branch of the US Forest Service has given a grant of US$1.7m to a pilot plant that will work on the production of cellulose nanocrystals. It is estimated that the plant will contribute US$600bln to the US economy by 2020.

Pros: This material out-toughs both carbon fibre and Kevlar while still being lightweight and is renewable and cheap to produce. Applications are far-reaching due to its optical, thermal and electronic properties, and can range from strengthening agents in paper manufacture to coating additives and barrier materials for packaging. While not a new material, investigations into wider applications are underway, such as in boards, walls, floors, coatings and retrofitting or building panels.

Professor Mizi Fan, who leads a nanocellulose research group at Brunel University, comments, ‘Its strength is comparable to aluminium and it has a strong surface area and high aspect ratio, so it can be easily combined with materials such as clay. Another benefit is that 25% of its mass is already nanostructured.’

Challenges: Moisture. The next step is to improve the material’s hydrophobic properties through surface engineering.

Polluted patterns

Textile and surface design graduate at Central Saint Martins, Alessia Giardino, has created an environmentally adaptive architectural solution that replicates nature by using living organisms to create surfaces that are ‘responsive, informative and decorative’.

Concrete Lace (pictured below [sic]) is a combination of concrete, organic materials, nanotechnology and textile techniques that can be used to regenerate urban and domestic environments. The base material is a concrete tile processed through photocatalytic cement, an innovative, sustainable technology containing TiO2.

‘The TiO2 reacts with light and so is able to break down pollution in the air, while purifying it,’ says Giardino. The TiO2 is applied using serigraphy printing, traditionally used in graphics and textiles. The parts that are protected by the TiO2 maintain a clean surface and prevent ageing and yellowing, while the uncovered surface turns into a catalyst for polluting substances and forms a pattern, making these surfaces look more appealing.’ Giardino is now seeking research and commercial partners to take the technology to market and test the technology on other substrates.

The cellulose nanocrystals (CNC) mentioned in the 2nd project description (excerpted from the news item) are also known as nancrystalline cellulose (NCC). The most fully realized of the projects (from the three excerpted from the news item) is Polluted patterns (from Alessia Giardino’s website)

Polluted patterns
Conceived as an artistic response to the problem of urban decay and working on the ethos of re-appropriation of negative aspects of the city, ‘Polluted Patterns’ emerge from the surface grime by selective cleaning technologies, creating a sort of ‘Living Wall’. Light-sensitive photo catalytic white cement or paint, have been screen printed to create ‘negative’ or ‘invisible’ motifs, that gradually become visible over time, as pollutants discolor the area of the surface not protected by these technologies. That section becomes catalyst of air bones pollutants, while the nanotechnology breaks down pollutants in the air though preserving the surface from their deposition.

Wrapped door
Pollution is defining a lace-like pattern assumed as metaphor of the poisoned air wrapping buildings, cities, everyday environment and affecting people health. Beyond is decorative aspect, is showing the increasing level of poor air quality we breath.

From Polluted Patterns slideshow on Alessia Giardino's website (http://www.alessiagiardino.com/pattern.html)

From Polluted Patterns slideshow on Alessia Giardino’s website (http://www.alessiagiardino.com/pattern.html)

Giardino’s work is being sponsored by Surface (from their home page),

Surface is a company specifically created to cater to the needs of the innovation hungry architectural and interior design community.

We call ourselves Surface because that’s what we supply.Bespoke surfaces.

At Surface, we gather together the most exciting, fresh and beautiful surface technologies and designs from across the globe into a one-stop destination website for those looking for the ultimate stand-out feature for their projects.

It seems the gamut at the November 2012 workshop ranged from work which is very much at the research stage (Iceclay) to materials which are being produced in pilot plants (CNC) to a product being readied for commercialization (Polluted patterns).