Tag Archives: cellulose nanocrystals

Future biomedical applications for CNC (cellulose nanocrystals, aka NCC [nanocrystalline cellulose]) from Polytechnic Institute of New York University (NYU-Poly)

It’s good to see a project that might result in applications for CNC (aka, NCC). I commented briefly about the CNC situation earlier today in my Nov. 25, 2013 posting about Lomiko Metals (based in Surrey, BC, Canada) and its focus on developing markets for its product (graphite flakes/graphene). By contrast, Canada’s CelluForce plant (in Québec) has stopped production to avoid adding to its stockpile (as per my Oct. 3, 2013 posting), Alberta has launched a pilot CNC plant (my Nov. 19, 2013 posting), Blue Goose Biorefineries in Saskatchewan was ramping up production according to my May 7, 2013 posting and someone, in a blog posting comment, claimed that Pure Liganin in BC produces CNC (which I cannot confirm since the company mentions neither CNC nor NCC).,

Back to happier matters, a research team from Polytechnic Institute of New York University (NYU-Poly) has discovered information that could be helpful for scientists working with protein polymers (from the Nov. 22, 2013 news item on Azonano,,

A team of researchers has uncovered critical information that could help scientists understand how protein polymers interact with other self-assembling biopolymers. The research helps explain naturally occurring nano-material within cells and could one day lead to engineered bio-composites for drug delivery, artificial tissue, bio-sensing, or cancer diagnosis.

The Nov. 21, 2013 NYU-Poly press release, which originated the news item, goes on to explain the CNC connection to this work,

Bionanocomposites provide a singular area of research that incorporates biology, chemistry, materials science, engineering, and nanotechnology. Medical researchers believe they hold particular promise because—unlike the materials that build today’s medical implants, for example—they are biodegradable and biocompatible, not subject to rejection by the body’s immune defenses. As biocomposites rarely exist isolated from other substances in nature, scientists do not yet understand how they interact with other materials such as lipids, nucleic acids, or other organic materials and on a molecular level. This study, which explored the ways in which protein polymers interact with another biopolymer, cellulose, provides the key to better understanding how biocomposite materials would interact with the human body for medical applications.

The materials analyzed were composed of bioengineered protein polymers and cellulose nanocrystals and hold promise for medical applications including non-toxic, targeted drug delivery systems. [emphasis mine] Such bionanocomposites could also be used as scaffolding for tissue growth, synthetic biomaterials, or an environmentally friendly replacement for petroleum-derived polymers currently in use.

I wonder if the researchers obtained their CNC from the production plant in Wisconsin (US), assuming it has opened since my July 27, 2012 posting featuring an announcement of future plans. Getting back to this latest work, here’s a link to and a citation for the paper,

Bionanocomposites: Differential Effects of Cellulose Nanocrystals on Protein Diblock Copolymers by Jennifer S. Haghpanah, Raymond Tu, Sandra Da Silva, Deng Yan, Silvana Mueller, Christoph Weder, E. Johan Foster, Iulia Sacui, Jeffery W. Gilman, and Jin Kim Montclare. Biomacromolecules, Article ASAP DOI: 10.1021/bm401304w Publication Date (Web): October 18, 2013
Copyright © 2013 American Chemical Society

This paper is behind a paywall.

Offhand I can think of only one Canadian laboratory (although I’m certain there are others), which is working on applications for CNC and that’s Mark MacLaclan’s lab at the University of British Columbia (UBC). For example, there is this ‘in press’ paper,

Shopsowitz, K.E.; Kelly, J.A.; Hamad, W.Y.; MacLachlan, M.J. “Biopolymer Templated Glass with a Twist: Controlling the Chirality, Porosity, and Photonic Properties of Silica with Cellulose Nanocrystals” Adv. Funct. Mater. 2013, in press. DOI: 10.1002/adfm.201301737

You can find more about MacLachlan’s work here.

Alberta gave its cellulose nanocrystal (or nanocrystalline cellolose) production plant a soft launch in September 2013

It’s been a little over two years since Alberta’s proposed cellulose nanocrystal (CNC), then called nanocrystalline cellulose (NCC), pilot plant was first announced (my July 5, 2011 posting). I gather that the plant was quietly opened in Sept. 2013. Finding a news release about the event has proved to be a challenge. The Alberta Innovates website does not list it in its Newsroom while the Alberta Innovates Technology Futures website does list a news release (September 12, 2013Alberta’s one-of-a-kind CNC pilot plant commissioned: Cellulose-based ‘wonder material’ now available to researchers, industry partnersf), despite numerous efforts on my part (try it yourself), I’m unable to access it. Happily, I was able to track down some information elsewhere.

First (in the order in which I found the information), there’s an Oct. 2, 2013 news item on the WorkingForest.com website submitted by Pulp and Paper Canada),

Alberta’s cellulose nanocrystals (CNC) pilot plant, which produces up to 100 kilograms of CNC per week, was commissioned in early September at Alberta Innovates-Technology Futures’ (AITF) Mill Woods facility before a crowd of researchers, industry leaders and government representatives.

The $5.5-million pilot plant, created through a collaboration of the governments of Canada and Alberta in partnership with industry under the Western Economic Partnership Agreement (WEPA), uses wood and straw pulp from plants such as flax and hemp to create CNC for testing in commercial applications that will lead to production.

“Alberta Innovates-Technology Futures is proud to host and operate Western Canada’s only CNC pilot plant,” said Stephen Lougheed, AITF’s president and CEO. “We’re able to provide researchers with more CNC than ever before, thereby accelerating the development of commercial applications.”

The grand opening of the CNC pilot plant’s is planned for 2014.

Then, there was more information about the plant and the event in Catherine Griwkowsky’s Sept. 12, 2013 article for the Edmonton Sun,

A new cellulose nanocrystals (CNCs) pilot plant will take wood and agricultural fires and turn it into a form that can make products stronger, give them sunlight-absorbing properties, add a negative electromagnetic charge and more.

The $5.5-million project in Mill Woods will churn out up to 100 kilograms of the crystals each week.

Technical Lead Frank Tosto said researchers will study various properties of the crystals, and work with an internal team as well as external industry and other researchers to transform knowledge of the properties into ideas for applications. Later, the team may experiment with unconventional sources of cellulose.

The CNCs can be used for drilling fluids, paints, industrial coatings, automotive components, building materials, plastics and packaging.

The process [of refining hemp, etc.] breaks down cellulose into smaller building blocks using a chemical process of acid hydrolysis, that separates crystal formations in cellulose from other structures. The width is between five to 10 nanometres with a length of 150 to 200 nanometers. To scale, cellulose fibre would be the size of a hockey rink and the nano crystal would be like a pen or pencil, he explained.

Ultimately, Tosto hopes they will find commercial applications for the CNCs. The pilot should last five to seven years. He said it’s hard to think outside the box when they don’t know where all the boxes are.

I’d love to know if any of the entrepreneurs who contacted me privately about accessing CNC so they could develop new applications are now able to purchase product from the Alberta plant or from the one in Quebec (CelluForce), which had a stockpile last I heard (my Oct. 3, 2013 posting). It seems odd to be building another plant when the country’s first such plant has stopped production. Meanwhile, there’s some action on the international scene. An Israeli startup company, Melodea has developed its own CNC/NCC extraction process and has received money to develop applications, from my Oct. 31, 2013 posting),

Melodea Ltd. is developing an economic ally viable industrial process for the extraction of NCC from the sludge of the paper industry, a waste stream produced at millions of tons around the world. The core of the novel technology was developed by the lab of Professor Oded Shoseyov from the Hebrew University of Jerusalem and was licensed exclusively to Melodea.

Moreover, the company develops unique technologies to self-assemble the NCC into ecologically friendly foams for industrial applications.

Melodea Ltd. announced today that it has been awarded above 1,000,000 Euro in 3 projects of the European Union Seventh Framework Program (FP7).

You’ll note Melodea’s process extracts CNC from the paper industry’s sludge which leads me to this question: will there be any discussion of this extracting CNC from sludge technique at the 2014 TAPPI (Technical Association for the Pulp, Paper, Packaging and Converting Industries) nanotechnology conference being held in Vancouver (Canada), June 23-26, 2014 (mentioned in my Nov. 14, 2013 posting about the conference’s submission deadline, Nov. 22, 2013)?

CelluForce finalist in Global Cleantech Cluster Association (GCCA) 2013 Later Stage Awards

The Global Cleantech Cluster Association (GCCA) is a cluster of cleantech cluster associations. In other words, if you lead a cleantech association whose membership includes cleantech businesses and ventures, you might call your organization a cleantech cluster and that organization could be eligible for membership in the global association (or cluster of clusters), the GCCA.

CelluForce, a Québec-based company, has emerged as one of 30 finalists in the GCCA’s 2013 Later Stage Awards. From the Nov. 11, 2013 CelluForce news release,

CelluForce, the world leader in the commercial development of Cellulose Nanocrystals (CNC), also referred to as NanoCrystalline Cellulose (CelluForce NCC™), is pleased to be recognized among the Global Top 30 in the prestigious Global Cleantech Cluster Association (GCCA) 2013 Later Stage Awards and the top three finalists in the lighting and energy efficiency category.

Each company was evaluated based on their merits in technological innovation and business acumen using the Keystone Compact Method. The Global Top 10 winners will be announced at the Corporate Cleantech Venture Day in Lathi, Finland on November 20th, 2013.

“The 2013 Global Top 30 demonstrate investability, strong product differentiation, scalable business models and have secured solid market traction in their various clean technology sectors,” said Dr. Peter Adriaens, Head Judge of the GCCA Later Stage Awards and developer of the Keystone Compact™ and associated scoring method.

“Narrowing down the nominations from 160 to 30 follows a detailed and robust process and analytics. The 2013 Global Top 30 some of the world’s most sought after equity

investable cleantech companies based on value capture potential in their CleanTech industry sectors.” An interview of Dr. Adriaens is available at http://www.globalcleantech.org/awards/criteria-and-eligibility/

“It is an honor to be part of this prestigious list of the world’s top Cleantech companies” said Jean Moreau, CelluForce President and CEO. “This honor is a reflection of the hard work and resilience demonstrated by the CelluForce team and its partners in developing commercial applications for CNC”, added Moreau. CelluForce is a member of Cleantech cluster Écotech Québec, a founding member of the Global Cleantech Cluster Association.

About CelluForce Inc.

CelluForce Inc. is the world leader in the commercial development of Cellulose Nanocrystals (CNC), also referred to as NanoCrystalline Cellulose (CelluForce NCC™).

The company is a joint venture of Domtar Inc. and FPInnovations. CelluForce manufactures NCC/CNC in the world’s first demonstration plant of its kind, located in Windsor, Québec, develops new applications for NCC/CNC, markets and sells it. The company’s head office is in Montreal. www.celluforce.com

About the Global Cleantech Cluster Association

The Global Cleantech Cluster Association (GCCA) is a network of 49 cleantech clusters, representing over 10,000 companies. It creates conduits for companies to

harness the tremendous benefits of international cleantech cluster collaboration in an efficient, affordable, and structured network. The GCCA provides a gateway for established and emerging cleantech companies to gain exposure to potential investors, new markets, influential networks, innovative technologies and best practices. GCCA was founded by swisscleantech, the Finnish Cleantech Cluster, and Watershed Capital, and Technica Communications. For more information about the GCCA, please visit www.globalcleantech.org.

I was not able to find either the source of GCCA funds, presumably they derive their income from memberships, or information about the prizes. There is this about the judging crriteria, from the GCCA’s Criteria and Eligibility webpage (Note: Links have been removed)

Judging Criteria
Companies must fit into one of the following categories:

Biofuels/BioEnergy
CleanWeb/Sustainable IT
Energy Storage/Smart Grid
Green Building
Lighting/Energy Efficiency
Smart Cities (products & services)
Solar & Wind Energy
Transportation
Waste Management
Water (Resource recovery, energy, treatment, etc)

Renowned experts of the global Cleantech investment community (VC’s, PE, etc.) and award category experts are forming the judging panel, coordinated by GCCA.

The following are areas that Award nominees will be judged on:

Clarity of the business strategy: does a viable business with significant markets exist?
The BIG Idea: why is it BIG in terms of breakthrough in innovation, concept and commercial potential?
Core team – profile & tenure: is there a relevant mix of requisite expertise and experience?
Funding: what are current and future sources?
ROI and/or exit strategy: is the business plan reasonable?
Sustainability: what is the positive impact on the environment?

Learn more about the The KeyStone Method™ and review the Keystone Score Brief.

Eligibility

To participate in the GCCA Later Stage Award, Cleantech clusters can nominate any later stage Cleantech company that is member of a cleantech cluster associated with GCCA.

Later stage companies are defined as companies with a proven track record (revenue) in their home market and the strategic goal to expand internationally, and/or a scalable technology or service with international growth potential (pre-revenue, but proven in pilot and demonstration projects).

Nominees may be disqualified if the GCCA jury (at their sole discretion) considers the nominee not eligible to participate.

Please send questions or comments about the GCCA Later Stage Award to award@globalcleantech.org

**All prizes are awarded at the discretion of the judging panel and all judging decisions are final and not subject to appeal.

You can find out more about the Keystone Compact here and Keystone Score here. Good luck to the folks at CelluForce on Nov. 20, 2013 (when they announce the winner in Finland). CelluForce’s two competitors at this stage are: SELC (Ireland) and ThinkEco (US)..

2013 (5th annual) Canadian Science Policy Conference announces some new (for this year) initiatives

An Oct. 29, 2013  announcement highlights some of the speakers you can expect at the 2013 (5th annual) Canadian Science Policy Conference (CSPC) being held in Toronto, Ontario from Nov. 20 – 22, 2013. The conference whose overarching theme is ScienceNext: Incubating Innovation and Ingenuity features (Note: I have bolded this year’s new initiatives),,

CSPC 2013 Welcomes Minister Rickford:
We are thrilled to announce that the Honourable Greg Rickford, [Canada’s] Minister of State (Science and Technology, and Federal Economic Development Initiative for Northern Ontario) will speak at CSPC 2013, more details to follow. Be sure not to miss it, register now!

Are you the next Rick Mercer? Bill Nye?
CSPC presents its first ever humorous speech contest, Whose Science is it Anyway? Thursday, November 21st at 9pm. To enter, send your name, contact info and 2-3 lines about your story to aanchal.kamra@gmail.com. Attractive prizes to be won! Deadline: 5pm, Friday, Nov. 15 (Finalists will be notified Monday, Nov. 18)

CSPC is now Accepting Donations:
We are quite pleased to announce that with the generous support from Ryerson University, CSPC can issue charitable tax receipts for donations. If you wish to donate please contact us or visit cspc2013.ca for more details. www.cspc2013.ca

> CONFERENCE HIGHLIGHTS

• 600+ participants, 28 panel sessions, 150+ speakers including:

– Hon. Reza Moridi, MPP,Ontario Minister of Research and Innovation

– John Knubley, Deputy Minister, Industry Canada

– Robert Hardt, President and CEO, Siemens Canada Limited

– Wendy Cukier, Vice President of Research and Innovation, Ryerson University

– Pierre Meulien, President and CEO, Genome Canada

– Paul Young, Vice President Research, University of Toronto

More exciting names are being added to the Program.

Inauguration of the Awards of Excellence in Science Policy – a first in Canada

• 3 pre conference full day workshops/symposiums

– Science Policy Nuts and Bolts
– Science Diplomacy
– Communication of Science

> CONFERENCE HONORARY CO-CHAIRS

• The Honourable Michael H. Wilson, Chairman, Barclays Capital Canada Inc. and Chancellor, University of Toronto

• Mandy Shapansky, President and Chief Executive Officer, Xerox Canada Ltd.

> CSPC 2013 CONFERENCE THEMES

• Private Sector R&D and Innovation: New Realities and New Models

• Emerging Trends: Science & Technology in International Trade and Diplomacy

• Science and Technology Communication

• Graduate Studies and Research Training: Prospects in a Changing Environment

• Emerging Issues in Canadian Science Policy

A couple of comments. I notice that Member of Parliament (NDP) Kennedy Stewart,, the Official Opposition Critic for Science and Technology, and member of the Standing Committee on Industry, Science and Technology, is included as a feature speaker this year. Last year (2012), he held an impromptu, after official conference presentation hours sessions on science policy. Good to see that he’s been included in the official programme for 2013. Perhaps next year (2014) will see the Liberal critic for Science and Technology. Ted Hsu as a speaker.

Pierre Lapointe is another speaker whose name caught my attention as he is the President and Chief Executive Officer of FPInnovations, one of the partners behind CelluForce (the other partner is Domtar), the Canadian nanocrystalline cellulose (NCC, aka, cellulose nanocrystals, CNC) initiative. In my Oct. 3, 2013 posting,  I noted that CelluForce had stopped producing NCC as they had a stockpile of the product. Unfortunately, it doesn’t look like there’ll be any mention of the stockpile since Lapointe is on a panel organized by Genome Canada and titled: The complexity of driving the bio-economy: Genomics, Canada’s natural resources and private-public collaborations.

Nanocellulose and forest residues at Luleå University of Technology (Sweden)

Swedish scientists have developed a new production technique which scales up the manufacture of cellulose nanfibres and cellulose nanocrystals (CNC, aka nanocrystalline cellulose [NCC]) from waste materials. From the Aug. 30,2013 news item on Nanowerk (Note: A link has been removed),

Luleå University of Technology is the first in Sweden with a new technology that scales up the production of nano-cellulose from forest residues. It may eventually give the forest industry profitable new products, e.g. nano-filters that can clean both the gases, industrial water and even drinking water. Better health and cleaner environment, both nationally and internationally, are some possible outcome

“There is large interest in this from industries, especially because our bionanofilters are expected to be of great importance for the purification of water all around the globe,” says Aji Mathew, Associate Professor at Luleå University of Technology, who leads the EU-funded project, NanoSelect.

The Luleå University of Technology Aug. 28, 2013 news release, which originated the news item, briefly describe the process and the magnitude of the increased production,

On Tuesday [Aug. 27, 2013], researchers at Luleå University of Technology demonstrated before representatives from the Industry and from research institutes how they have managed to scale up the process of manufacture of nano-cellulose of two different residues from the pulp industry. One is from Domsjö in Örnsköldsvik in the form of a fiber product that is grinded down to tiny nano fibers in a special machine. Through this process, the researchers have managed to increase the amount of the previous two kilograms per day to 15 kg per day. Another byproduct is nanocrystals that have been successfully scaled up from 50 to 640 grams / day. The process is possible to scale up and therefore highly interesting for the forest industry.

As noted in the news item, this development is an outcome of the EU- (European Union) funded NanoSelect project, from the Project Details webpage,

NanoSelect aims to design, develop and optimize novel bio-based foams/filters/membranes/adsorbent materials with high and specific selectivity using nanocellulose/nanochitin and combinations thereof for decentralized industrial and domestic water treatment. NanoSelect proposes a novel water purification approach combining the physical filtration process and
the adsorption process exploring the capability of the nanocellulose and/or nanochitin (with or without functionalization) to selectively adsorb, store and desorb contaminants from industrial water and drinking water while passing through a highly porous or permeable membrane.

As the news release notes,

Nano Filter for purification of process water and drinking water is not the only possible product made of nano-cellulose since cellulose has much greater potential.

– Large-scale production of nano-cellulose is necessary to meet a growing interest to use bio-based nanoparticles in a variety of products, says Kristiina Oksman professor at Luleå University of Technology.

Nano filters is today developed at Imperial College, London, in close collaboration with the researchers at Luleå University of Technology.

– We have optimized the process to produce nano filters, we can control the pore size and thus the filter porosity. It’s actually just a piece of paper and the beauty of this piece of paper is that it is stable in water, not like toilet paper that dissolves easily in water, but stable, says Professor Alexander Bismarck at Imperial College.

Nice to hear more about CNC developments.

Crystalline cellulose nanofibers and biomass fuel

Perhaps one day the researchers who work with cellulose at the nanoscale will agree to some kind of terminology. Unfortunately, that day does not seem to be scheduled for the near future as per the latest research from Los Alamos National Laboratory and the Great Lakes Bioenergy Research Center (GLBRC) in the June 19, 2013 news item on ScienceDaily,

Improved methods for breaking down cellulose nanofibers are central to cost-effective biofuel production and the subject of new research from Los Alamos National Laboratory (LANL) and the Great Lakes Bioenergy Research Center (GLBRC). Scientists are investigating the unique properties of crystalline cellulose nanofibers to develop novel chemical pretreatments and designer enzymes for biofuel production from cellulosic — or non-food — plant derived biomass.

“Cellulose is laid out in plant cell walls as crystalline nanofibers, like steel reinforcements embedded in concrete columns,” says GLBRC’s Shishir Chundawat. “The key to cheaper biofuel production is to unravel these tightly packed nanofibers more efficiently into soluble sugars using fewer enzymes.”

The June 19, 2013 Los Alamos National Laboratory news release, which originated the news item, explains the new technique in more detail,

An article published this week in the Proceedings of the National Academy of Sciences suggests—counter-intuitively—that increased binding of enzymes to cellulose polymers doesn’t always lead to faster breakdown into simple sugars. In fact, Chundawat’s research team found that using novel biomass pretreatments to convert cellulose to a unique crystalline structure called cellulose III reduced native enzyme binding while increasing sugar yields by as much as five times.

The researchers had previously demonstrated that altering the crystal structure of native cellulose to cellulose III accelerates enzymatic deconstruction; however, the recent observation that cellulose III increased sugar yields with reduced levels of bound enzyme was unexpected. To explain this finding, Chundawat and a team of LANL researchers led by Gnana Gnanakaran and Anurag Sethi developed a mechanistic kinetic model indicating that the relationship between enzyme affinity for cellulose and catalytic efficiency is more complex than previously thought.

Cellulose III was found to have a less sticky surface that makes it harder for native enzymes to get stuck non-productively on it, unlike untreated cellulose surfaces. The model further predicts that the enhanced enzyme activity, despite reduced binding, is due to the relative ease with which enzymes are able to pull out individual cellulose III chains from the pretreated nanofiber surface and then break them apart into simple sugars.

“These findings are exciting because they may catalyze future development of novel engineered enzymes that are further tailored for conversion of cellulose III rich pretreated biomass to cheaper fuels and other useful compounds that are currently derived from non-renewable fossil fuels,” says Gnanakaran.

Here’s a link to and a citation for the published paper,

Increased enzyme binding to substrate is not necessary for more efficient cellulose hydrolysis by Dahai Gaoa, Shishir P. S. Chundawat, Anurag Sethic, Venkatesh Balana, S. Gnanakaranc, and Bruce E. Dalea. Published online before print June 19, 2013, doi: 10.1073/pnas.1213426110
PNAS June 19, 2013

There is open access to the article (I’m not sure if this is permanent or temporary).

As I hinted at the beginning of this piece, there are a number of terms used to describe cellulose at the nanoscale. For example, there’s nanocrystalline cellulose (NCC) which is also known as cellulose nanocrystals (CNC); this second term now seems to be preferred. My latest writing on nanocellulose, which seems to be a generic term covering all of the versions cellulose at the nanoscale is in a May 21, 2013 posting about some nanotoxicology studies and in a May 7, 2013 posting about a Saskatchewan-based (Canada) biorefinery (Blue Goose Biorefinery) and its production of CNC.

There are many more here on the topic and, if you’re interested, you may want to try CelluForce, FPInnovations, CNC, and/or NCC, as well as, nanocellulose or cellulose, as blog search terms.

Brazil, Canada, and an innovation, science, and technology forum in Vancouver (Canada)

The Brazil-Canada Chamber of Commerce (BCCC) is presenting, in partnership with Simon Fraser University’s (SFU) Beedie School of Business, an all-morning forum on June 17, 2013. From the SFU Vancouver Events: June 14 – 21, 2013 announcement (Note: Links have been removed),

Monday, June 17 [2013]

Brazil-Canada Business, Innovation, Science, and Technology Forum

Time: 8-11:30am

Place: Segal Graduate Business School, 500 Granville St.

Cost: $35-70, register online

Join us for a morning focused on Business Innovation and Science & Tecnology opportunities in the Brazilian economy. The opening speakers, Ambassador Sergio Florencio, Consul General and Dr. Jeremy Hall will provide an overview of the landscape in Brazil. The panel discussion includes industry leaders who have piloted extensive business in Brazil specifically in the agriculture, mining and infrastructure fields: Marcelo Sarkis, Heenan Blaikie; Ray Castelli, Weatherhaven and Rogerio Tippe, Javelin Partners. If you are interested in conducting business in Brazil and would like to understand more about the dynamics of the Brazilian economy and how businesses operate, please register now.

If the event is about business, innovation, science, and technology, it seems curious the only mentions of science and/or technology in the event description are confined to a few of the panelists’ interests in agriculture, mining, and whatever they mean by infrastructure.

Brazil is one of the BRICS (Brazil, Russia,India, China, and South Africa) countries and, from what I understand, this very loose coalition is eager to take a leadership position vis à vis science, technology, and innovation supplanting the dominance of the US, Japan, and the European Union.

In the early 1990s, I wrote a paper about science and technology transfer and noted that Brazil was entering a new period of development after years of the country’s science and technology efforts (scientists) being isolated from the rest of the world in a failed  attempt to create a powerhouse international enterprise.

Some 20 years later, the decision to join the rest of the science and technology world seems to have been successful. Brazil is set to host the 2014 World Cup for soccer (or, as most of the world calls it, football) and the summer Olympics in 2016. (Sports are often correlated with science and technology advances.) I don’t believe any other country has ever attempted to host two such large international sports events within two years of each other. That’s a pretty confident attitude.

There are two areas of science and technology research in Brazil that are of particular interest to me, brain research and the work on cellulose nanocrystals (CNC), also known as, nanocrystalline cellulose (NCC).

While the focus was on Miguel Nicolelis and Duke University (US), the recent announcement of brain-to-brain communication via the Internet featured a research facility in Brazil (from my Mar. 4, 2013 posting),

Miguel Nicolelis, a professor at Duke University, has been making international headlines lately with two brain projects. The first one about implanting a brain chip that allows rats to perceive infrared light was mentioned in my Feb. 15, 2013 posting. The latest project is a brain-to-brain (rats) communication project as per a Feb. 28, 2013 news release on *EurekAlert,

Researchers have electronically linked the brains of pairs of rats for the first time, enabling them to communicate directly to solve simple behavioral puzzles. A further test of this work successfully linked the brains of two animals thousands of miles apart—one in Durham, N.C., and one in Natal, Brazil.

The results of these projects suggest the future potential for linking multiple brains to form what the research team is calling an “organic computer,” which could allow sharing of motor and sensory information among groups of animals. The study was published Feb. 28, 2013, in the journal Scientific Reports.

“Our previous studies with brain-machine interfaces had convinced us that the rat brain was much more plastic than we had previously thought,” said Miguel Nicolelis, M.D., PhD, lead author of the publication and professor of neurobiology at Duke University School of Medicine. “In those experiments, the rat brain was able to adapt easily to accept input from devices outside the body and even learn how to process invisible infrared light generated by an artificial sensor. So, the question we asked was, ‘if the brain could assimilate signals from artificial sensors, could it also assimilate information input from sensors from a different body?’”

One of Nicolelis’s other goals is to have someone with quadriplegia kick the opening ball for the Brazil-hosted 2014 World Cup (Walk Again Project). From my Mar. 16, 2012 posting,

It is the exoskeleton described on the Walk Again Project home page that Nicolelis is hoping will enable a young Brazilian quadriplegic to deliver the opening kick for the 2014 World Cup (soccer/football) in Brazil.

Moving on to the other area of interest, CNC research , which in Canada is discussed in terms of the forestry industry (I’ve blogged about this extensively, the search term NCC should fetch most if not all of my postings on the topic), is taking a different tack in Brazil where the focus is on pineapple and banana fibres. My Mar. 28, 20111 posting (Nanocellulose fibres, pineapples, bananas, and cars) focuses on cellulose and plastic,

Brazilian researchers are working on ways to use nanocellulose fibres from various plants to reinforce plastics in the automotive industry. From the March 28, 2011 news item on Nanowerk,

Study leader Alcides Leão, Ph.D., said the fibers used to reinforce the new plastics may come from delicate fruits like bananas and pineapples, but they are super strong. Some of these so-called nano-cellulose fibers are almost as stiff as Kevlar, the renowned super-strong material used in armor and bulletproof vests. Unlike Kevlar and other traditional plastics, which are made from petroleum or natural gas, nano-cellulose fibers are completely renewable.

My second and, to date, only other posting (June 16, 2011) about the work in Brazil features a transcript of an interview with CNC researcher, Alcides Leão.

Finally, I have a few factoids which I will tie together, loosely, and try to show how they relate to this forum. First, São Paulo, Brazil hosts the world’s second oldest and one of its most important biennial visual arts events. (BTW, the next one, Bienal de São Paulo,  is in 2014.) Second, the recent Council of Canadian Academies assessment, State of Science and Technology in Canada, 2012, stated that Canada rates very highly in six areas, one of those areas being the Visual and Performing Arts. Admittedly Canada’s prominence in the visual and performing is fueled largely by efforts in Québec (as per the assessment), still, one would think there might be some value in trying to include that sector in this  forum and encourage the local visual and performing arts technology industry to make connections with the Brazilian industry.

Finally for those of you who have persisted, here’s the link to buy tickets for the June 17, 2012 forum.

ETA June 21, 2013: The protests in Brazil have attracted worldwide attention and according to a June 21,2013 posting by Dillon Rand on Salon.com there are: 5 signs Brazil’s’ not ready to host the World Cup.

Gary Goodyear rouses passions: more on Canada’s National Research Council and its new commitment to business

Gary Goodyear’s, Minister of State (Science and Technology), office in attempting to set the record straight has, inadvertently, roused even more passion in Phil Plait’s (Slate.com blogger) bosom and inspired me to examine more commentary about the situation regarding the NRC and its ‘new’ commitment to business.

Phil Plait in a May 22, 2013 followup to one 0f his recent postings (I have the details about Plait’s and other commentaries in my May 13, 2013 posting about the NRC’s recent declarations) responds to an email from Michele-Jamali Paquette, the director of communication for Goodyear (Note: A link has been removed),

I read the transcripts, and assuming they are accurate, let me be very clear: Yes, the literal word-for-word quotation I used was incorrect, and one point I made was technically and superficially in error. But the overall point—that this is a terrible move by the NRC and the conservative Canadian government, short-changing real science—still stands. And, in my opinion, Goodyear’s office is simply trying to spin what has become a PR problem.

I’ll note that in her email to me, Paquette quoted my own statement:

John MacDougal [sic], President of the NRC, literally said, “Scientific discovery is not valuable unless it has commercial value”

Paquette took exception to my use of the word “literally,” emphasizing it in her email. (The link, in both her email and my original post, goes to the Toronto Sun story with the garbled quotation.) Apparently MacDougal did not literally say that. But the objection strikes me as political spin since the meaning of what MacDougal said at the press conference is just as I said it was in my original post.

As I pointed out in my first post: Science can and should be done for its own sake. It pays off in the end, but that’s not why we do it. To wit …

Paquette’s choice of what issues (the 2nd issue was Plait’s original description of the NRC as a funding agency) to dispute seem odd and picayune as they don’t have an impact on Plait’s main argument,

Unfortunately, despite these errors, the overall meaning remains the same: The NRC is moving away from basic science to support business better, and the statements by both Goodyear and MacDougal [sic] are cause for concern.

Plait goes on to restate his argument and provide a roundup of commentaries. It’s well worth reading for the roundup alone.  (One picayune comment from me, I wish Plait would notice that the head of Canada’s National Research Council’s name is spelled this way, John McDougall.)

Happily, Nassif Ghoussoub has also chimed in with a May 22, 2013 posting (on his Piece of Mind blog) regarding the online discussion (Note: Links have been removed),

The Canadian twitter world has been split in the last couple of days. … But then, you have the story of the Tories’ problem with science, be it defunding, muzzling, disbelieving, doubting, preventing, delegitimizing etc. The latter must have restarted with the incredible announcement about the National Research Council (NRC), presented as “Canada sells out science” in Slate, and as “Failure doesn’t come cheap” in Maclean’s. What went unnoticed was the fact that the restructuring turned out to be totally orthogonal to the recommendations of the Jenkins report about the NRC. Then came the latest Science, Technology and Innovation Council (STIC) report, which showed that Canada’s expenditure on research and development has fallen from 16th out of 41 comparable countries in the year Stephen Harper became prime minister, to 23rd in 2011. Paul Wells seems to be racking up hits on his Maclean’s article,  “Stephen Harper and the knowledge economy: perfect strangers.”  But the story of the last 48 hours has been John Dupuis’s chronology of what he calls, “The Canadian war on science” and much more.

Yes, it’s another roundup but it’s complementary (albeit with one or two repetitions) since Plait does not seem all that familiar with the Canadian scene (I find it’s always valuable to have an outside perspective) and Nassif is a longtime insider.

John Dupuis’ May 20, 2013 posting (on his Confessions of a Science Librarian blog), mentioned by both Nassif and Plait, provides an extraordinary listing of stories ranging from 2006 through to 2013 whose headlines alone paint a very bleak picture of the practice of science in Canada,

As is occasionally my habit, I have pulled together a chronology of sorts. It is a chronology of all the various cuts, insults, muzzlings and cancellations that I’ve been able to dig up. Each of them represents a single shot in the Canadian Conservative war on science. It should be noted that not every item in this chronology, if taken in isolation, is necessarily the end of the world. It’s the accumulated evidence that is so damning.

As I’ve noted before, I am no friend of Stephen Harper and his Conservative government and many of their actions have been reprehensible and, at times, seem childishly spiteful but they do occasionally get something right. There was a serious infrastructure problem in Canada. Buildings dedicated to the pursuit of science were sadly aged and no longer appropriate for the use to which they were being put. Harper and his government have poured money into rebuilding infrastructure and for that they should be acknowledged.

As for what the Conservatives are attempting with this shift in direction for the National Research Council (NRC), which has been ongoing for at least two years as I noted in my May 13, 2013 posting, I believe they are attempting to rebalance the Canadian research enterprise.  It’s generally agreed that Canada historically has very poor levels of industrial research and development (R&D) and high levels of industrial R&D are considered, internationally, as key to a successful economy. (Richard Jones, Pro-Vice Chancellor for Research and Innovation at the University of Sheffield, UK, discusses how a falling percentage of industrial R&D, taking place over decades,  is affecting the UK economy in a May 10, 2013 commentary on the University of  Sheffield SPERI [Sheffield Political Economy Research Institute] website.)

This NRC redirection when taken in conjunction with the recent StartUp visa programme (my May 20, 2013 posting discusses Minister of Immigration Jason Kenney’s recent recruitment tour in San Francisco [Silicon Valley]),  is designed to take Canada and Canadians into uncharted territory—the much desired place where we develop a viable industrial R&D sector and an innovative economy in action.

In having reviewed at least some of the commentary, there are a couple of questions left unasked about this international obsession with industrial R&D,

  • is a country’s economic health truly tied to industrial R&D or is this ‘received’ wisdom?
  • if industrial R&D is the key to economic health, what would be the best balance between it and the practice of basic science?

As for the Canadian situation, what might be some of the unintended consequences? It occurs to me that if scientists are rewarded for turning their research into commercially viable products they might be inclined to constrain access to materials. Understandable if the enterprise is purely private but the NRC redirection is aimed at bringing together academics and private enterprise in a scheme that seems a weird amalgam of both.

For example, cellulose nanocrystals (CNC) are not easily accessed if you’re a run-of-the-mill entrepreneur. I’ve had more than one back-channel request about how to purchase the material and it would seem that access is tightly controlled by the academics and publicly funded enterprise, in this case, a private business, who produce the material. (I’m speaking of the FPInnovations and Domtar comingling in CelluForce, a CNC production facility and much more. It would make a fascinating case study on how public monies are used to help finance private enterprises and their R&D efforts; the relationship between nongovernmental agencies (FPInnovations, which I believe was an NRC spinoff), various federal public funding agencies, and Domtar, a private enterprise; and the power dynamics between all the players including the lowly entrepreneur.

Blue Goose Biorefineries scales up production of cellulose nanocrystals (CNC) and more

I last mentioned Saskatchewan’s (Canada) Blue Goose Biorefineries in a Jan. 22, 2013 posting about its activities with regard to cellulose nanocrystals. I’m a little late to the party but there’s an Apr. 11, 2013 news release on the Advanced Foods and Materials website which notes that Blue Goose Biorefineries’ production of cellulose nanocrystals (CNC also sometimes known as nanocrystalline cellulose, NCC) has been scaled up,

Advanced Foods and Materials (AFM) Canada and Blue Goose Biorefineries Inc. (BGB), are pleased to announce the successful scale up of biorefining technology for the production of high value microcrystalline cellulose (MCC), cellulose nanocrystals (CNC), lignin, and green platform chemicals from flax and hemp straw.

In collaboration with the University of Saskatchewan’s College of Agriculture and Bioresources Bioprocessing Pilot Plant, and POS Bio-Sciences, BGB’s proprietary Renewable Residuals RefiningTM (R3TM) biorefining technology was successfully scaled up to process 100 kg of pulp in a reaction volume of 2500L to produce microcrystalline cellulose and cellulose nanocrystals of high purity, along with lignin and green platform chemicals as by-products. Throughout this process, the technology has shown promising advantages over existing biorefining methods including cost, yield, environmental impact, and flexibility. Necessary process steps demonstrated include biomass preparation, dewatering and washing, reaction mixing and crystalline cellulose washing. The project also successfully demonstrated the spray drying of the cellulose crystals at POS Bio-Sciences.

It’s exciting to hear that there might be more production of CNC in Canada, as well as, microcrystalline cellulose, lignin, and other by-products,. It seems where CNC is concerned that demand exceeds supply (I get the occasional query from someone trying to find a supplier).

I have more information about Advanced Foods and Materials Canada in my Jan. 22, 2013 posting. As well, here are links to the POS Bio-Sciences website and more information about the University of Saskatchewan’s Bioprocessing Pilot Plant.

ETA May 7, 2013 4:30 pm PDT: Dr. Bernard Laarveld of Blue Goose Biorefineries (BGB) very kindly noted this in an email to me today,

… we are now planning to develop a pilot plant for the production of NCC (aka CNC) and MCC and are raising the funding. This development through BGB is more driven from the private sector in partnership with Advanced Food Materials Canada.  We intend to process about 500 kg  of flax or hemp straw per day, and this would generate about 250 kg per day of crystalline cellulose. BGB has an advantage through low cost of production.

Very exciting news and I wish the Dr. Laarveld and the folks at BGB all the best.

Waterloo Institute of Nanotechnology/EcoSynthetix industrial partnership and an interlaced relationship

The EcoSynthetix and Waterloo Institute for Nanotechnology partnership announced today (Mar. 13, 2013) is an example of how tightly interlaced the relationships between academic institutions and their graduates’ start-up companies can be. A Mar. 13, 2013 news item on Nanowerk describes the partnership,

EcoSynthetix Inc. and the Waterloo Institute for Nanotechnology at the University of Waterloo have joined forces through an industrial partnership to collaborate on new applications for EcoSynthetix’ EcoSphere® technology. The five-year agreement will be jointly funded through an EcoSynthetix and NSERC (National Sciences and Engineering Research Council) Collaborative Research and Development Grant. The project matches the scientific expertise from the University of Waterloo in macromolecular science with the sustainability benefits of EcoSphere® bio-based nanoparticles which are based on green chemistry. The goal of the project is to broaden the scientific knowledge base of the EcoSphere® technology to support its introduction into new application areas.

The Mar. 13, 2013 EcoSynthetix news release, which originated the news item, mentions the relationship in passing while extolling the virtues of the partnership,

“As a global centre of excellence for nanotechnology research, this project represents a great opportunity for our institute, faculty and students at the University, to collaborate with a local innovator to further our understanding of the technology and its potential applications,” said Dr. Arthur J. Carty, Executive Director of the Waterloo Institute for Nanotechnology (“WIN”) and an independent director of the board of EcoSynthetix. [emphasis mine] “Nanotechnology is a leading-edge, enabling technology that holds the promise of a lasting economic benefit for jobs and investment in the materials, energy and healthcare sectors. EcoSynthetix’s innovative nanotechnology has the potential to impact a wide-array of markets that would benefit from a sustainable alternative to petroleum-based products.”

“This ECO-WIN collaboration involves four professors and eight graduate students at the Waterloo Institute for Nanotechnology and is a great example of how industry and universities can work together to advance an exciting new area of science to benefit the community,” said Dr. Steven Bloembergen, Executive Vice President, Technology of EcoSynthetix. “Our EcoSphere® technology is already commercial and providing sustainable benefits in three separate markets today. Our team’s primary focus at this stage is near-term product development and product enhancements of carbohydrate-based biopolymers. By working with the Institute of Nanotechnology to deepen our understanding of the basic science, we can identify new future applications that could benefit from our sustainable biobased materials.”

The EcoSphere® technology is being commercially utilized as biobased latex products providing alternatives to petroleum-based binders in the coated paper and paperboard market. [emphasis mine] The goal of this project is to generate a greater understanding of the properties of EcoSphere® biolatex® binders by establishing a knowledge base that could enable tailor-made novel particles with the desired properties for a given application. The project team will be chemically modifying the nanoparticles and then characterizing how the properties of the novel particles are affected by these changes.

I don’t understand what “independent director” means in this context. Is the term meant to suggest that it’s a coincidence Carty is WIN’s executive director and a member of the EcoSynthetix board? Or, does it mean that he’s not employed by the company? If any readers care to clarify the matter, please do leave a comment. In any event, the EcoSynthetix timeline suggests the company has a close relationship with the University of Waterloo as it was founded in 1996 by graduates  (from the company’s About Us History Timeline webpage),

EcosynthetixTimeline

As for the product line which birthed this partnership, there’s a disappointing lack of technical detail about Ecosphere biolatex binders. Here’s the best I can find on the company website (from the Ecosphere Biolatex Binders Performance page),

The smaller particle size characteristic of biolatex binders results in increased binder strength and performance. In coated paper, it provides improved aesthetics; a rich, bright finish; enhanced open structure and excellent printability across all grades.

I wonder if some of this new work will be focused on ways to use CNC (cellulose nanocrytals or NCC, nanocrystalline cellulose) in addition to the company’s previously developed “bio-based nanoparticles”  to enhance the product which, as I highlighted earlier, sells to the “coated paper and paperboard market.” From the CelluForce (the CNC/NCC production plant in Quebec) Applications page,

NCC’s properties and many potential forms enable many uses, including:

  • Biocomposites for bone replacement and tooth repair
  • Pharmaceuticals and drug delivery
  • Additives for foods and cosmetics
  • Improved paper and building products
  • Advanced or “intelligent” packaging
  • High-strength spun fibres and textiles
  • Additives for coatings, paints, lacquers and adhesives
  • Reinforced polymers and innovative bioplastics
  • Advanced reinforced composite materials
  • Recyclable interior and structural components for the transportation industry
  • Aerospace and transportation structures
  • Iridescent and protective films
  • Films for optical switching
  • Pigments and inks
  • Electronic paper printers
  • Innovative coatings and new fillers for papermaking

Since I’m already speculating, I will note I’ve had a couple of requests for information on how to access NCC/CNC from entrepreneurs who’ve not been successful at obtaining the material from the few existing production plants such as CelluForce and the one in the US. It seems only academics can get access.

One last comment about this ‘partnership’, I’d dearly love to know what relationships, if any exist, between the proponents and the NSERC committee which approved the funding.

Interestingly, Carty is the chair for the recently convened expert panel for the Council of Canadian Academies’ The State of Canada’s Science Culture assessment, as per my Dec. 19, 2012 post about the announcement of his appointment. This latest development casts a new light on the panel (my Feb. 22, 2013 post notes my reaction to the expert panel’s membership) and the meaning of science culture in Canada.