Monthly Archives: December 2016

Chimera state: simultaneous synchrony and asynchrony

It turns out there’s more than one kind of chimera. (I published a Sept. 7, 2016 post about chimeras that are animal/human hybrids and a US public consultation on the matter.)

The chimera being investigated by researchers at the University of New Mexico (US) is of an altogether different kind. From a Nov. 15, 2016 American Institute of Physics (AIP) news release (also on EurekAlert),

Order and disorder might seem dichotomous conditions of a functioning system, yet both states can, in fact, exist simultaneously and durably within a system of oscillators, in what’s called a chimera state. Taking its name from a composite creature in Greek mythology, this exotic state still holds a lot of mystery, but its fundamental nature offers potential in understanding governing dynamics across many scientific fields. A research team at the University of New Mexico has recently advanced this understanding with work that will be published this week in the journal Chaos, from AIP Publishing.

“A system of oscillators” may sound obscure, but it actually describes, in a very general but fundamental way, all sorts of physical systems.

“Lots of biological systems can be thought of as populations of oscillators. The heartbeat is just oscillating heart cells that a wave propagates on. And neurons in the brain are oscillators as well, and have been treated with these methods,” said Karen Blaha, a post-doctoral researcher at the University of New Mexico working on the project. “But doing experiments on those systems is really, really hard. The cells can die, and if you can manipulate them in a way that you can measure the data, they may not be behaving as they do naturally.”

For this reason, the team, led by Francesco Sorrentino, a mechanical engineering professor at the University of New Mexico, built on previous work done to understand chimera states with mechanical oscillators, in this case a collection of metronomes, resting on coupled platforms.

“The ultimate goal is that these systems are better behaved than the biological systems that we hope eventually they might be good proxies for,” Blaha said.

The team built a system of three coupled platforms, each supporting up to 15 ticking metronomes whose motions were individually tracked. A chimera state in this system consisted of in-phase, or synchronous, motion of a subset of the metronomes, and asynchronous motion of the others. By varying characteristics of the system, such as the strength of coupling between the platforms or the number of metronomes, they could deduce which factors led to more perfect chimera states.

Of particular interest in this experiment was the effect symmetries of the system had on the emergence of chimera states. Sorrentino and his team looked at, for example, the effect of having the same versus different coupling strengths of the outer platforms to the center platform.

“It puts together a new ingredient that kind of makes the whole thing more complex. Basically we are wondering how this type of mixed behavior can occur in systems that have symmetries. And our work is experimental so we see this chimera state in systems with symmetries,” Sorrentino said.

In addition to developing a method for better understanding these important, complex systems, Sorrentino views the effort to be a powerful educational tool. The tabletop scale and visual nature of the measurements and effects offer students more direct involvement with the concepts being investigated.

“It’s a full experience for the student [and] we have a broad authorship,” Sorrentino said, highlighting the collaboration between undergraduates, graduate students and senior researchers. “It’s really a team effort.”

Future work by the diverse team will investigating other symmetries, as well as varying factors such as coupling method. They also plan to add methods of controlling the system and synchrony. “We are working in several directions. Definitely the symmetries are something we will keep in mind and try to generalize to more complex situations,” Sorrentino said.

Here’s a link to and a citation for the paper,

Symmetry effects on naturally arising chimera states in mechanical oscillator networks by Karen Blaha, Ryan J. Burrus, Jorge L. Orozco-Mora, Elvia Ruiz-Beltrán, Abu B. Siddique, V. D. Hatamipour, and Francesco Sorrentino. Chaos 26, 116307 (2016); http://dx.doi.org/10.1063/1.4965993

This paper appears to be open access.

International news bits: Israel and Germany and Cuba and Iran

I have three news bits today.

Germany

From a Nov. 14, 2016 posting by Lynn L. Bergeson and Carla N. Hutton for The National Law Review (Note: A link has been removed),

The German Federal Ministry of Education and Research (BMBF) recently published an English version of its Action Plan Nanotechnology 2020. Based on the success of the Action Plan Nanotechnology over the previous ten years, the federal government will continue the Action Plan Nanotechnology for the next five years.  Action Plan Nanotechnology 2020 is geared towards the priorities of the federal government’s new “High-Tech Strategy” (HTS), which has as its objective the solution of societal challenges by promoting research.  According to Action Plan Nanotechnology 2020, the results of a number of research projects “have shown that nanomaterials are not per se linked with a risk for people and the environment due to their nanoscale properties.”  Instead, this is influenced more by structure, chemical composition, and other factors, and is thus dependent on the respective material and its application.

A Nov. 16, 2016 posting on Out-Law.com provides mores detail about the plan (Note: A link has been removed),

Eight ministries have been responsible for producing a joint plan on nanotechnology every five years since 2006, the Ministry said. The ministries develop a common approach that pools strategies for action and fields of application for nanotechnology, it [Germany’s Federal Ministry of Education and Research] said.

The German public sector currently spends more than €600 million a year on nanotechnology related developments, and 2,200 organisations from industry, services, research and associations are registered in the Ministry’s nanotechnology competence map, the report said.

“There are currently also some 1,100 companies in Germany engaged [in] the use of nanotechnology in the fields of research and development as well as the marketing of commercial products and services. The proportion of SMEs [small to medium enterprises?] is around 75%,” it said.

Nanotechnology-based product innovations play “an increasingly important role in many areas of life, such as health and nutrition, the workplace, mobility and energy production”, and the plan “thus pursues the objective of continuing to exploit the opportunities and potential of nanotechnology in Germany, without disregarding any potential risks to humans and the environment.”, the Ministry said.

Technology law expert Florian von Baum of Pinsent Masons, the law firm behind Out-Law.com said: “The action plan aims to achieve and secure Germany’s critical lead in the still new nanotechnology field and to recognise and use the full potential of nanotechnology while taking into account possible risks and dangers of this new technology.”

..

“With the rapid pace of development and the new applications that emerge every day, the government needs to ensure that the dangers and risks are sufficiently recognised and considered. Nanotechnology will provide great and long-awaited breakthroughs in health and ecological areas, but ethical, legal and socio-economic issues must be assessed and evaluated at all stages of the innovation chain,” von Baum said.

You can find Germany’s Action Plan Nanotechnology 2020 here, all 64 pp.of it.

Israel and Germany

A Nov. 16, 2016 article by Shoshanna Solomon for The Times of Israel announces a new joint (Israel-Germany) nanotechnology fund,

Tsrael and Germany have set up a new three-year, €30 million plan to promote joint nanotechnology initiatives and are calling on companies and entities in both countries to submit proposals for funding for projects in this field.

“Nanotech is the industry of the future in global hi-tech and Israel has set a goal of becoming a leader of this field, while cooperating with leading European countries,” Ilan Peled, manager of Technological Infrastructure Arena at the Israel Innovation Authority, said in a statement announcing the plan.

In the past decade nanotechnology, seen by many as the tech field of the future, has focused mainly on research. Now, however, Israel’s Innovation Authority, which has set up the joint program with Germany, believes the next decade will focus on the application of this research into products — and countries are keen to set up the right ecosystem that will draw companies operating in this field to them.

Over the last decade, the country has focused on creating a “robust research foundation that can support a large industry,” the authority said, with six academic research institutes that are among the world’s most advanced.

In addition, the authority said, there are about 200 new startups that were established over the last decade in the field, many in the development stage.

I know it’s been over 70 years since the events of World War II but this does seem like an unexpected coupling. It is heartening to see that people can resolve the unimaginable within the space of a few generations.

Iran and Cuba

A Nov. 16, 2016 Mehr News Agency press release announces a new laboratory in Cuba,

Iran is ready to build a laboratory center equipped with nanotechnology in one of nano institutes in Cuba, Iran’s VP for Science and Technology Sorena Sattari said Tuesday [Nov. 15, 2016].

Sorena Sattari, Vice-President for Science and Technology, made the remark in a meeting with Fidel Castro Diaz-Balart, scientific adviser to the Cuban president, in Tehran on Tuesday [November 15, 2016], adding that Iran is also ready to present Cuba with a gifted package including educational services related to how to operate the equipment at the lab.

During the meeting, Sattari noted Iran’s various technological achievements including exports of biotechnological medicine to Russia, the extensive nanotechnology plans for high school and university students as well as companies, the presence of about 160 companies active in the field of nanotechnology and the country’s achievements in the field of water treatment.

“We have sealed good nano agreements with Cuba, and are ready to develop our technological cooperation with this country in the field of vaccines and recombinant drugs,” he said.

Sattari maintained that the biggest e-commerce company in the Middle East is situated in Iran, adding “the company which was only established six years ago now sales over $3.5 million in a day, and is even bigger than similar companies in Russia.”

The Cuban official, for his part, welcomed any kind of cooperation with Iran, and thanked the Islamic Republic for its generous proposal on establishing a nanotechnology laboratory in his country.

This coupling is not quite so unexpected as Iran has been cozying up to all kinds of countries in its drive to establish itself as a nanotechnology leader.

Using acoustic waves to move fluids at the nanoscale

A Nov. 14, 2016 news item on ScienceDaily describes research that could lead to applications useful for ‘lab-on-a-chip’ operations,

A team of mechanical engineers at the University of California San Diego [UCSD] has successfully used acoustic waves to move fluids through small channels at the nanoscale. The breakthrough is a first step toward the manufacturing of small, portable devices that could be used for drug discovery and microrobotics applications. The devices could be integrated in a lab on a chip to sort cells, move liquids, manipulate particles and sense other biological components. For example, it could be used to filter a wide range of particles, such as bacteria, to conduct rapid diagnosis.

A Nov. 14, 2016 UCSD news release (also on EurrekAlert), which originated the news item, provides more information,

The researchers detail their findings in the Nov. 14 issue of Advanced Functional Materials. This is the first time that surface acoustic waves have been used at the nanoscale.

The field of nanofluidics has long struggled with moving fluids within channels that are 1000 times smaller than the width of a hair, said James Friend, a professor and materials science expert at the Jacobs School of Engineering at UC San Diego. Current methods require bulky and expensive equipment as well as high temperatures. Moving fluid out of a channel that’s just a few nanometers high requires pressures of 1 megaPascal, or the equivalent of 10 atmospheres.

Researchers led by Friend had tried to use acoustic waves to move the fluids along at the nano scale for several years. They also wanted to do this with a device that could be manufactured at room temperature.

After a year of experimenting, post-doctoral researcher Morteza Miansari, now at Stanford, was able to build a device made of lithium niobate with nanoscale channels where fluids can be moved by surface acoustic waves. This was made possible by a new method Miansari developed to bond the material to itself at room temperature.  The fabrication method can be easily scaled up, which would lower manufacturing costs. Building one device would cost $1000 but building 100,000 would drive the price down to $1 each.

The device is compatible with biological materials, cells and molecules.

Researchers used acoustic waves with a frequency of 20 megaHertz to manipulate fluids, droplets and particles in nanoslits that are 50 to 250 nanometers tall. To fill the channels, researchers applied the acoustic waves in the same direction as the fluid moving into the channels. To drain the channels, the sound waves were applied in the opposite direction.

By changing the height of the channels, the device could be used to filter a wide range of particles, down to large biomolecules such as siRNA, which would not fit in the slits. Essentially, the acoustic waves would drive fluids containing the particles into these channels. But while the fluid would go through, the particles would be left behind and form a dry mass. This could be used for rapid diagnosis in the field.

Here’s a link to and a citation for the paper,

Acoustic Nanofluidics via Room-Temperature Lithium Niobate Bonding: A Platform for Actuation and Manipulation of Nanoconfined Fluids and Particles by Morteza Miansari and James R. Friend. Advanced Functional Materials DOI: 10.1002/adfm.201602425 Version of Record online: 20 SEP 2016
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This paper is behind a paywall.

They do have an animation sequence illustrating the work but it could be considered suggestive and is, weirdly, silent,

 

 

“Science Fiction by Real Scientists” campaign success

This news bit concerns a science fiction short  story anthology and novel series from scientists and experts and a now completed fundraising campaign. From a Nov. 14, 2016 Springer Books press release on EurekAlert,

Springer Nature and Humble Bundle have raised a charitable contribution of $22,000 through the science fiction book campaign “Science Fiction by Real Scientists.” One half of the proceeds, $11,000, goes to the Science Fiction & Fantasy Writers of America’s Givers Fund. The same amount goes to the U.S. Fund for UNICEF as part of the global children’s charity’s annual Halloween fundraising drive. Humble Bundle supports a number of charities by offering media packages to its customers on a pay-what-you-want basis.

During the campaign, Springer offered a specially priced eBook bundle from its Science and Fiction series, consisting of nine full novels, two books of short stories and five nonfiction books. Readers were able to choose how their purchase dollars were allocated between the publisher and charity. Starting at just one dollar, customers could name their price, increasing their contribution to upgrade their bundles or contribute more to charity.

The Science and Fiction series, launched in 2012 by Springer, is a unique publishing program for fiction written by actual scientists and experts in scientific fields. Each novel or anthology of short stories is accompanied by an extensive afterword that explains, in lay terms, the current scientific theory or findings that serve as the basis for the fictional work.

Mia Kravitz, Director Global eRetail at Springer Nature, said, “Springer was so pleased to work with Humble Bundle on this worthwhile effort to aid children globally as well as support writers and artists in the science fiction genre. Pushing the envelope for scientific inquiry is part of our mission, and this is a fun way to bring current research to a wider audience.”

Here’s a bit more information about the “Science and Fiction” series from a Sept. 20, 2016 Springer Books press release,

The Springer series Science and Fiction was launched in 2012 and comprises entertaining and thought-provoking books which appeal equally to science buffs, scientists and science fiction fans. The idea was born out of the recognition that scientific discovery and the creation of plausible fictional scenarios are often two sides of the same coin. Each science fiction book, with an afterword on the science underlying the tale, relies on an understanding of the way the world works, coupled with the imaginative ability to invent new or alternative explanations and even other worlds.

Christian Caron, Executive Editor Physics at Springer, said the concept developed when a Springer author, astrobiologist Dirk Schulze-Makuch, published his first hard science fiction novel on Amazon. “Our very first thought was, why couldn’t we do this?” he said. “Our authors, all of them scientists and experts at some forefront of research, would of course have an interface with speculative science in their fields.”

The books in Springer’s Science and Fiction series explore and exploit the borderlands between accepted science and its fictional counterpart. Uncovering mutual influences, promoting fruitful interaction, and narrating and analyzing fictional scenarios, they serve as a reaction vessel for inspired new ideas in science, technology and beyond.

You can find a list of books in the series here. Note: I found forthcoming titles in 2017 and titles dating back to 2014. Springer made the announcement in 2012 but didn’t publish any books in the series until 2014.

Functional hybrid system that can connect human tissue with electronic devices

I’ve tagged this particular field of interest ‘machine/flesh’ because I find it more descriptive than ‘bio-hybrid system’ which was the term used in a Nov. 15, 2016 news item on phys.org,

One of the biggest challenges in cognitive or rehabilitation neurosciences is the ability to design a functional hybrid system that can connect and exchange information between biological systems, like neurons in the brain, and human-made electronic devices. A large multidisciplinary effort of researchers in Italy brought together physicists, chemists, biochemists, engineers, molecular biologists and physiologists to analyze the biocompatibility of the substrate used to connect these biological and human-made components, and investigate the functionality of the adhering cells, creating a living biohybrid system.

A Nov.15, 2016 American Institute of Physics news release on EurekAlert, which originated the news item, details the investigation,

In an article appearing this week in AIP Advances, from AIP Publishing, the research team used the interaction between light and matter to investigate the material properties at the molecular level using Raman spectroscopy, a technique that, until now, has been principally applied to material science. Thanks to the coupling of the Raman spectrometer with a microscope, spectroscopy becomes a useful tool for investigating micro-objects such as cells and tissues. Raman spectroscopy presents clear advantages for this type of investigation: The molecular composition and the modi?cation of subcellular compartments can be obtained in label-free conditions with non-invasive methods and under physiological conditions, allowing the investigation of a large variety of biological processes both in vitro and in vivo.

Once the biocompatibility of the substrate was analyzed and the functionality of the adhering cells investigated, the next part of this puzzle is connecting with the electronic component. In this case a memristor was used.

“Its name reveals its peculiarity (MEMory ResISTOR), it has a sort of “memory”: depending on the amount of voltage that has been applied to it in the past, it is able to vary its resistance, because of a change of its microscopic physical properties,” said Silvia Caponi, a physicist at the Italian National Research Council in Rome. By combining memristors, it is possible to create pathways within the electrical circuits that work similar to the natural synapses, which develop variable weight in their connections to reproduce the adaptive/learning mechanism. Layers of organic polymers, like polyaniline (PANI) a semiconductor polymer, also have memristive properties, allowing them to work directly with biological materials into a hybrid bio-electronic system.

“We applied the analysis on a hybrid bio-inspired device but in a prospective view, this work provides the proof of concept of an integrated study able to analyse the status of living cells in a large variety of applications that merges nanosciences, neurosciences and bioelectronics,” said Caponi. A natural long-term objective of this work would be interfacing machines and nervous systems as seamlessly as possible.

The multidisciplinary team is ready to build on this proof of principle to realize the potential of memristor networks.

“Once assured the biocompatibility of the materials on which neurons grow,” said Caponi, “we want to define the materials and their functionalization procedures to find the best configuration for the neuron-memristor interface to deliver a full working hybrid bio-memristive system.”

Caption: These are immunofluorescence analysis of SH-SY5Y cells treated for 5 days with 10uM Retinoic Acid and 50ng/ml BDNF for the next 3 days. The DAPI fluorescence stain is blue and Beta-tubulin is green. Credit: Caponi, et al.

Caption: These are immunofluorescence analysis of SH-SY5Y cells treated for 5 days with 10uM Retinoic Acid and 50ng/ml BDNF for the next 3 days. The DAPI fluorescence stain is blue and Beta-tubulin is green. Credit: Caponi, et al.

Here’s a link to and a citation for the paper,

A multidisciplinary approach to study the functional properties of neuron-like cell models constituting a living bio-hybrid system: SH-SY5Y cells adhering to PANI substrate by S. Caponi, S. Mattana, M. Ricci, K. Sagini, L. J. Juarez-Hernandez, A. M. Jimenez-Garduño, N. Cornella, L. Pasquardini, L. Urbanelli, P. Sassi, A. Morresi, C. Emiliani, D. Fioretto, M. Dalla Serra, C. Pederzolli, S. Iannotta, P. Macchi, and C. Musio. AIP Advances 6, 111303 (2016); http://dx.doi.org/10.1063/1.4966587

This paper appears to be open access.

Solar-powered clothing

This research comes from the University of Central Florida (US) and includes a pop culture reference to the movie “Back to the Future.”  From a Nov. 14, 2016 news item on phys.org,

Marty McFly’s self-lacing Nikes in Back to the Future Part II inspired a UCF scientist who has developed filaments that harvest and store the sun’s energy—and can be woven into textiles.

The breakthrough would essentially turn jackets and other clothing into wearable, solar-powered batteries that never need to be plugged in. It could one day revolutionize wearable technology, helping everyone from soldiers who now carry heavy loads of batteries to a texting-addicted teen who could charge his smartphone by simply slipping it in a pocket.

A Nov. 14, 2016 University of Central Florida news release (also on EurekAlert) by Mark Schlueb, which originated the news item, expands on the theme,

“That movie was the motivation,” Associate Professor Jayan Thomas, a nanotechnology scientist at the University of Central Florida’s NanoScience Technology Center, said of the film released in 1989. “If you can develop self-charging clothes or textiles, you can realize those cinematic fantasies – that’s the cool thing.”

Thomas already has been lauded for earlier ground-breaking research. Last year, he received an R&D 100 Award – given to the top inventions of the year worldwide – for his development of a cable that can not only transmit energy like a normal cable but also store energy like a battery. He’s also working on semi-transparent solar cells that can be applied to windows, allowing some light to pass through while also harvesting solar power.

His new work builds on that research.

“The idea came to me: We make energy-storage devices and we make solar cells in the labs. Why not combine these two devices together?” Thomas said.

Thomas, who holds joint appointments in the College of Optics & Photonics and the Department of Materials Science & Engineering, set out to do just that.

Taking it further, he envisioned technology that could enable wearable tech. His research team developed filaments in the form of copper ribbons that are thin, flexible and lightweight. The ribbons have a solar cell on one side and energy-storing layers on the other.

Though more comfortable with advanced nanotechnology, Thomas and his team then bought a small, tabletop loom. After another UCF scientists taught them to use it, they wove the ribbons into a square of yarn.

The proof-of-concept shows that the filaments could be laced throughout jackets or other outwear to harvest and store energy to power phones, personal health sensors and other tech gadgets. It’s an advancement that overcomes the main shortcoming of solar cells: The energy they produce must flow into the power grid or be stored in a battery that limits their portability.

“A major application could be with our military,” Thomas said. “When you think about our soldiers in Iraq or Afghanistan, they’re walking in the sun. Some of them are carrying more than 30 pounds of batteries on their bodies. It is hard for the military to deliver batteries to these soldiers in this hostile environment. A garment like this can harvest and store energy at the same time if sunlight is available.”

There are a host of other potential uses, including electric cars that could generate and store energy whenever they’re in the sun.

“That’s the future. What we’ve done is demonstrate that it can be made,” Thomas said. “It’s going to be very useful for the general public and the military and many other applications.”

The proof-of-concept shows that the filaments could be laced throughout jackets or other outwear to harvest and store energy to power phones, personal health sensors and other tech gadgets. It's an advancement that overcomes the main shortcoming of solar cells: the energy they produce must flow into the power grid or be stored in a battery that limits their portability. Credit: UCF Read more at: http://phys.org/news/2016-11-future-solar-nanotech-powered.html#jCp

The proof-of-concept shows that the filaments could be laced throughout jackets or other outwear to harvest and store energy to power phones, personal health sensors and other tech gadgets. It’s an advancement that overcomes the main shortcoming of solar cells: the energy they produce must flow into the power grid or be stored in a battery that limits their portability. Credit: UCF

Here’s a link to and a citation for the paper,

Wearable energy-smart ribbons for synchronous energy harvest and storage by Chao Li, Md. Monirul Islam, Julian Moore, Joseph Sleppy, Caleb Morrison, Konstantin Konstantinov, Shi Xue Dou, Chait Renduchintala, & Jayan Thomas. Nature Communications 7, Article number: 13319 (2016)  doi:10.1038/ncomms13319 Published online: 11 November 2016

This paper is open access.

Dexter Johnson in a Nov. 15, 2016 posting on his blog Nanoclast on the IEEE (Institute of Electrical and Electronics Engineers) provides context for this research and, in this excerpt, more insight from the researcher,

In a telephone interview with IEEE Spectrum, Thomas did concede that at this point, the supercapacitor was not capable of storing enough energy to replace the batteries entirely, but could be used to make a hybrid battery that would certainly reduce the load a soldier carries.

Thomas added: “By combining a few sets of ribbons (2-3 ribbons) in parallel and connecting these sets (3-4) in a series, it’s possible to provide enough power to operate a radio for 10 minutes. …

For anyone interested in knowing more about how this research fits into the field of textiles that harvest energy, I recommend reading Dexter’s piece.

The brittleness of molybdenum diselenide

With the finding that molybdenum diselenide is not as strong as previously believed, industry may want to reconsider 2D materials before incorporating them in new products according to a Rice University (Texas, US) scientist. From a Nov. 14, 2016 news item on Nanowerk,

Scientists at Rice University have discovered that an atom-thick material being eyed for flexible electronics and next-generation optical devices is more brittle than they expected.

The Rice team led by materials scientist Jun Lou tested the tensile strength of two-dimensional, semiconducting molybdenum diselenide and discovered that flaws as small as one missing atom can initiate catastrophic cracking under strain.

The finding may cause industry to look more carefully at the properties of 2-D materials before incorporating them in new technologies, he said.

 

A Nov. 14, 2016 Rice University news release (also on EurekAlert), which originated the news item, provides more insight into the research,

“It turns out not all 2-D crystals are equal,” said Lou, a Rice professor of materials science and nanoengineering. “Graphene is a lot more robust compared with some of the others we’re dealing with right now, like this molybdenum diselenide. We think it has something to do with defects inherent to these materials.”

The defects could be as small as a single atom that leaves a vacancy in the crystalline structure, he said. “It’s very hard to detect them,” he said. “Even if a cluster of vacancies makes a bigger hole, it’s difficult to find using any technique. It might be possible to see them with a transmission electron microscope, but that would be so labor-intensive that it wouldn’t be useful.”

Molybdenum diselenide is a dichalcogenide, a two-dimensional semiconducting material that appears as a graphene-like hexagonal array from above but is actually a sandwich of metallic atoms between two layers of chalcogen atoms, in this case, selenium. Molybdenum diselenide is being considered for use as transistors and in next-generation solar cells, photodetectors and catalysts as well as electronic and optical devices.

Lou and colleagues measured the material’s elastic modulus, the amount of stretching a material can handle and still return to its initial state, at 177.2 (plus or minus 9.3) gigapascals. Graphene is more than five times as elastic. They attributed the large variation to pre-existing flaws of between 3.6 and 77.5 nanometers.

Its fracture strength, the amount of stretching a material can handle before breaking, was measured at 4.8 (plus or minus 2.9) gigapascals. Graphene is nearly 25 times stronger.

Part of the project led by Rice postdoctoral researcher Yingchao Yang required moving molybdenum diselenide from a growth chamber in a chemical vapor deposition furnace to a microscope without introducing more defects. Yang solved the problem using a dry transfer process in place of a standard acid washing that would have ruined the samples.

To test samples, Yang placed rectangles of molybdenum diselenide onto a sensitive electron microscope platform invented by the Lou group. Natural van der Waals forces held the samples in place on springy cantilever arms that measured the applied stress.

Lou said the group attempted to measure the material’s fracture toughness, an indicator of how likely cracks are to propagate, as they had in an earlier study on graphene. But they found that pre-cutting cracks into molybdenum diselenide resulted in it shattering before stress could be applied, he said.

“The important message of this work is the brittle nature of these materials,” Lou said. “A lot of people are thinking about using 2-D crystals because they’re inherently thin. They’re thinking about flexible electronics because they are semiconductors and their theoretical elastic strength should be very high. According to our calculations, they can be stretched up to 10 percent.

“But in reality, because of the inherent defects, you rarely can achieve that much strength. The samples we have tested so far broke at 2 to 3 percent (of the theoretical maximum) at most,” Lou said. “That should still be fine for most flexible applications, but unless they find a way to quench the defects, it will be very hard to achieve the theoretical limits.”

 

When seen from above, the atoms in two-dimensional molybdenum diselenide resemble a hexagonal grid, like graphene. But in reality, the darker molybdenum atoms are sandwiched between top and bottom layers of selenide atoms. Rice University researchers tested the material for its tensile strength. Courtesy of the Lou Group

When seen from above, the atoms in two-dimensional molybdenum diselenide resemble a hexagonal grid, like graphene. But in reality, the darker molybdenum atoms are sandwiched between top and bottom layers of selenide atoms. Rice University researchers tested the material for its tensile strength. Courtesy of the Lou Group

Here’s a link to and a citation for the paper,

 

Brittle Fracture of 2D MoSe2 by Yingchao Yang, Xing Li, Minru Wen, Emily Hacopian, Weibing Chen, Yongji Gong, Jing Zhang, Bo Li, Wu Zhou, Pulickel M. Ajayan, Qing Chen, Ting Zhu, and Jun Lou. Advanced Materials DOI: 10.1002/adma.201604201 Version of Record online: 3 NOV 2016

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This paper is behind a paywall.

Montreal Neuro creates a new paradigm for technology transfer?

It’s one heck of a Christmas present. Canadian businessmen Larry Tannenbaum and his wife Judy have given the Montreal Neurological Institute (Montreal Neuro), which is affiliated with McGill University, a $20M donation. From a Dec. 16, 2016 McGill University news release,

The Prime Minister of Canada, Justin Trudeau, was present today at the Montreal Neurological Institute and Hospital (MNI) for the announcement of an important donation of $20 million by the Larry and Judy Tanenbaum family. This transformative gift will help to establish the Tanenbaum Open Science Institute, a bold initiative that will facilitate the sharing of neuroscience findings worldwide to accelerate the discovery of leading edge therapeutics to treat patients suffering from neurological diseases.

‟Today, we take an important step forward in opening up new horizons in neuroscience research and discovery,” said Mr. Larry Tanenbaum. ‟Our digital world provides for unprecedented opportunities to leverage advances in technology to the benefit of science.  That is what we are celebrating here today: the transformation of research, the removal of barriers, the breaking of silos and, most of all, the courage of researchers to put patients and progress ahead of all other considerations.”

Neuroscience has reached a new frontier, and advances in technology now allow scientists to better understand the brain and all its complexities in ways that were previously deemed impossible. The sharing of research findings amongst scientists is critical, not only due to the sheer scale of data involved, but also because diseases of the brain and the nervous system are amongst the most compelling unmet medical needs of our time.

Neurological diseases, mental illnesses, addictions, and brain and spinal cord injuries directly impact 1 in 3 Canadians, representing approximately 11 million people across the country.

“As internationally-recognized leaders in the field of brain research, we are uniquely placed to deliver on this ambitious initiative and reinforce our reputation as an institution that drives innovation, discovery and advanced patient care,” said Dr. Guy Rouleau, Director of the Montreal Neurological Institute and Hospital and Chair of McGill University’s Department of Neurology and Neurosurgery. “Part of the Tanenbaum family’s donation will be used to incentivize other Canadian researchers and institutions to adopt an Open Science model, thus strengthening the network of like-minded institutes working in this field.”

What they don’t mention in the news release is that they will not be pursuing any patents (for five years according to one of the people in the video but I can’t find text to substantiate that time limit*; there are no time limits noted elsewhere) on their work. For this detail and others, you have to listen to the video they’ve created,

The CBC (Canadian Broadcasting Corporation) news online Dec. 16, 2016 posting (with files from Sarah Leavitt and Justin Hayward) adds a few personal details about Tannenbaum,

“Our goal is simple: to accelerate brain research and discovery to relieve suffering,” said Tanenbaum.

Tanenbaum, a Canadian businessman and chairman of Maple Leaf Sports and Entertainment, said many of his loved ones suffered from neurological disorders.

“I lost my mother to Alzheimer’s, my father to a stroke, three dear friends to brain cancer, and a brilliant friend and scientist to clinical depression,” said Tanenbaum.

He hopes the institute will serve as the template for science research across the world, a thought that Trudeau echoed.

“This vision around open science, recognizing the role that Canada can and should play, the leadership that Canadians can have in this initiative is truly, truly exciting,” said Trudeau.

The Neurological Institute says the pharmaceutical industry is supportive of the open science concept because it will provide crucial base research that can later be used to develop drugs to fight an array of neurological conditions.

Jack Stilgoe in a Dec. 16, 2016 posting on the Guardian blogs explains what this donation could mean (Note: Links have been removed),

With the help of Tanenbaum’s gift of 20 million Canadian dollars (£12million) the ‘Neuro’, the Montreal Neurological Institute and Hospital, is setting up an experiment in experimentation, an Open Science Initiative with the express purpose of finding out the best way to realise the potential of scientific research.

Governments in science-rich countries are increasingly concerned that they do not appear to reaping the economic returns they feel they deserve from investments in scientific research. Their favoured response has been to try to bridge what they see as a ‘valley of death’ between basic scientific research and industrial applications. This has meant more funding for ‘translational research’ and the flowering of technology transfer offices within universities.

… There are some success stories, particularly in the life sciences. Patents from the work of Richard Axel at Columbia University at one point brought the university almost $100 million per year. The University of Florida received more than $150 million for inventing Gatorade in the 1960s. The stakes are high in the current battle between Berkely and MIT/Harvard over who owns the rights to the CRISPR/Cas9 system that has revolutionised genetic engineering and could be worth billions.

Policymakers imagine a world in which universities pay for themselves just as a pharmaceutical research lab does. However, for critics of technology transfer, such stories blind us to the reality of university’s entrepreneurial abilities.

For most universities, evidence of their money-making prowess is, to put it charitably, mixed. A recent Bloomberg report shows how quickly university patent incomes plunge once we look beyond the megastars. In 2014, just 15 US universities earned 70% of all patent royalties. British science policy researchers Paul Nightingale and Alex Coad conclude that ‘Roughly 9/10 US universities lose money on their technology transfer offices… MIT makes more money from selling T-shirts than it does from licensing’. A report from the Brookings institute concluded that the model of technology transfer ‘is unprofitable for most universities and sometimes even risks alienating the private sector’. In the UK, the situation is even worse. Businesses who have dealings with universities report that their technology transfer offices are often unrealistic in negotiations. In many cases, academics are, like a small child who refuses to let others play with a brand new football, unable to make the most of their gifts. And areas of science outside the life sciences are harder to patent than medicines, sports drinks and genetic engineering techniques. Trying too hard to force science towards the market may be, to use the phrase of science policy professor Keith Pavitt, like pushing a piece of string.

Science policy is slowly waking up to the realisation that the value of science may lie in people and places rather than papers and patents. It’s an idea that the Neuro, with the help of Tanenbaum’s gift, is going to test. By sharing data and giving away intellectual property, the initiative aims to attract new private partners to the institute and build Montreal as a hub for knowledge and innovation. The hypothesis is that this will be more lucrative than hoarding patents.

This experiment is not wishful thinking. It will be scientifically measured. It is the job of Richard Gold, a McGill University law professor, to see whether it works. He told me that his first task is ‘to figure out what to counts… There’s going to be a gap between what we would like to measure and what we can measure’. However, he sees an open-mindedness among his colleagues that is unusual. Some are evangelists for open science; some are sceptics. But they share a curiosity about new approaches and a recognition of a problem in neuroscience: ‘We haven’t come up with a new drug for Parkinson’s in 30 years. We don’t even understand the biological basis for many of these diseases. So whatever we’re doing at the moment doesn’t work’. …

Montreal Neuro made news on the ‘open science’ front in January 2016 when it formally announced its research would be freely available and that researchers would not be pursuing patents (see my January 22, 2016 posting).

I recommend reading Stilgoe’s posting in its entirety and for those who don’t know or have forgotten, Prime Minister’s Trudeau’s family has some experience with mental illness. His mother has been very open about her travails. This makes his presence at the announcement perhaps a bit more meaningful than the usual political presence at a major funding announcement.

*The five-year time limit is confirmed in a Feb. 17, 2017 McGill University news release about their presentations at the AAAS (American Association for the Advancement of Science) 2017 annual meeting) on EurekAlert,

umpstarting Neurological Research through Open Science – MNI & McGill University

Friday, February 17, 2017, 1:30-2:30 PM/ Room 208

Neurological research is advancing too slowly according to Dr. Guy Rouleau, director of the Montreal Neurological Institute (MNI) of McGill University. To speed up discovery, MNI has become the first ever Open Science academic institution in the world. In a five-year experiment, MNI is opening its books and making itself transparent to an international group of social scientists, policymakers, industrial partners, and members of civil society. They hope, by doing so, to accelerate research and the discovery of new treatments for patients with neurological diseases, and to encourage other leading institutions around the world to consider a similar model. A team led by McGill Faculty of Law’s Professor Richard Gold will monitor and evaluate how well the MNI Open Science experiment works and provide the scientific and policy worlds with insight into 21st century university-industry partnerships. At this workshop, Rouleau and Gold will discuss the benefits and challenges of this open-science initiative.

The Center for Nanotechnology in Society at the University of California at Santa Barbara offers a ‘swan song’ in three parts

I gather the University of California at Santa Barbara’s (UCSB) Center for Nanotechnology in Society is ‘sunsetting’ as its funding runs out. A Nov. 9, 2016 UCSB news release by Brandon Fastman describes the center’s ‘swan song’,

After more than a decade, the UCSB Center for Nanotechnology in Society research has provided new and deep knowledge of how technological innovation and social change impact one another. Now, as the national center reaches the end of its term, its three primary research groups have published synthesis reports that bring together important findings from their 11 years of activity.

The reports, which include policy recommendations, are available for free download at the CNS web site at

http://www.cns.ucsb.edu/irg-synthesis-reports.

The ever-increasing ability of scientists to manipulate matter on the molecular level brings with it the potential for science fiction-like technologies such as nanoelectronic sensors that would entail “merging tissue with electronics in a way that it becomes difficult to determine where the tissue ends and the electronics begin,” according to a Harvard chemist in a recent CQ Researcher report. While the life-altering ramifications of such technologies are clear, it is less clear how they might impact the larger society to which they are introduced.

CNS research, as detailed the reports, addresses such gaps in knowledge. For instance, when anthropologist Barbara Herr Harthorn and her collaborators at the UCSB Center for Nanotechnology in Society (CNS-UCSB), convened public deliberations to discuss the promises and perils of health and human enhancement nanotechnologies, they thought that participants might be concerned about medical risks. However, that is not exactly what they found.

Participants were less worried about medical or technological mishaps than about the equitable distribution of the risks and benefits of new technologies and fair procedures for addressing potential problems. That is, they were unconvinced that citizens across the socioeconomic spectrum would share equal access to the benefits of therapies or equal exposure to their pitfalls.

In describing her work, Harthorn explained, “Intuitive assumptions of experts and practitioners about public perceptions and concerns are insufficient to understanding the societal contexts of technologies. Relying on intuition often leads to misunderstandings of social and institutional realities. CNS-UCSB has attempted to fill in the knowledge gaps through methodologically sophisticated empirical and theoretical research.”

In her role as Director of CNS-UCSB, Harthorn has overseen a larger effort to promote the responsible development of sophisticated materials and technologies seen as central to the nation’s economic future. By pursuing this goal, researchers at CNS-UCSB, which closed its doors at the end of the summer, have advanced the role for the social, economic, and behavioral sciences in understanding technological innovation.

Harthorn has spent the past 11 years trying to understand public expectations, values, beliefs, and perceptions regarding nanotechnologies. Along with conducting deliberations, she has worked with toxicologists and engineers to examine the environmental and occupational risks of nanotechnologies, determine gaps in the U.S. regulatory system, and survey nanotechnology experts. Work has also expanded to comparative studies of other emerging technologies such as shale oil and gas extraction (fracking).

Along with Harthorn’s research group on risk perception and social response, CNS-UCSB housed two other main research groups. One, led by sociologist Richard Appelbaum, studied the impacts of nanotechnology on the global economy. The other, led by historian Patrick McCray, studied the technologies, communities, and individuals that have shaped the direction of nanotechnology research.

Appelbaum’s research program included studying how state policies regarding nanotechnology – especially in China and Latin America – has impacted commercialization. Research trips to China elicited a great understanding of that nation’s research culture and its capacity to produce original intellectual property. He also studied the role of international collaboration in spurring technological innovation. As part of this research, his collaborators surveyed and interviewed international STEM graduate students in the United States in order to understand the factors that influence their choice whether to remain abroad or return home.

In examining the history of nanotechnology, McCray’s group explained how the microelectronics industry provided a template for what became known as nanotechnology, examined educational policies aimed at training a nano-workforce, and produced a history of the scanning tunneling microscope. They also penned award-winning monographs including McCray’s book, The Visioneers: How a Group of Elite Scientists Pursued Space Colonies, Nanotechnologies, and Limitless Future.

Reaching the Real World

Funded as a National Center by the US National Science Foundation in 2005, CNS-UCSB was explicitly intended to enhance the understanding of the relationship between new technologies and their societal context. After more than a decade of funding, CNS-UCSB research has provided a deep understanding of the relationship between technological innovation and social change.

New developments in nanotechnology, an area of research that has garnered $24 billion in funding from the U.S. federal government since 2001, impact sectors as far ranging as agriculture, medicine, energy, defense, and construction, posing great challenges for policymakers and regulators who must consider questions of equity, sustainability, occupational and environmental health and safety, economic and educational policy, disruptions to privacy, security and even what it means to be human. (A nanometer is roughly 10,000 times smaller than the diameter of a human hair.)  Nanoscale materials are already integrated into food packaging, electronics, solar cells, cosmetics, and pharmaceuticals. They are far in development for drugs that can target specific cells, microscopic spying devices, and quantum computers.

Given such real-world applications, it was important to CNS researchers that the results of their work not remain confined within the halls of academia. Therefore, they have delivered testimony to Congress, federal and state agencies (including the National Academies of Science, the Centers for Disease Control and Prevention, the Presidential Council of Advisors on Science and Technology, the U.S. Presidential Bioethics Commission and the National Nanotechnology Initiative), policy outfits (including the Washington Center for Equitable Growth), and international agencies (including the World Bank, European Commission, and World Economic Forum). They’ve collaborated with nongovernmental organizations. They’ve composed policy briefs and op eds, and their work has been covered by numerous news organizations including, recently, NPR, The New Yorker, and Forbes. They have also given many hundreds of lectures to audiences in community groups, schools, and museums.

Policy Options

Most notably, in their final act before the center closed, each of the three primary research groups published synthesis reports that bring together important findings from their 11 years of activity. Their titles are:

Exploring Nanotechnology’s Origins, Institutions, and Communities: A Ten Year Experiment in Large Scale Collaborative STS Research

Globalization and Nanotechnology: The Role of State Policy and International Collaboration

Understanding Nanotechnologies’ Risks and Benefits: Emergence, Expertise and Upstream Participation.

A sampling of key policy recommendations follows:

1.     Public acceptability of nanotechnologies is driven by: benefit perception, the type of application, and the risk messages transmitted from trusted sources and their stability over time; therefore transparent and responsible risk communication is a critical aspect of acceptability.

2.     Social risks, particularly issues of equity and politics, are primary, not secondary, drivers of perception and need to be fully addressed in any new technology development. We have devoted particular attention to studying how gender and race/ethnicity affect both public and expert risk judgments.

3.     State policies aimed at fostering science and technology development should clearly continue to emphasize basic research, but not to the exclusion of supporting promising innovative payoffs. The National Nanotechnology Initiative, with its overwhelming emphasis on basic research, would likely achieve greater success in spawning thriving businesses and commercialization by investing more in capital programs such as the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, self-described as “America’s seed fund.”

4.     While nearly half of all international STEM graduate students would like to stay in the U.S. upon graduation, fully 40 percent are undecided — and a main barrier is current U.S. immigration policy.

5.     Although representatives from the nanomaterials industry demonstrate relatively high perceived risk regarding engineered nanomaterials, they likewise demonstrate low sensitivity to variance in risks across type of engineered nanomaterials, and a strong disinclination to regulation. This situation puts workers at significant risk and probably requires regulatory action now (beyond the currently favored voluntary or ‘soft law’ approaches).

6.     The complex nature of technological ecosystems translates into a variety of actors essential for successful innovation. One species is the Visioneer, a person who blends engineering experience with a transformative vision of the technological future and a willingness to promote this vision to the public and policy makers.

Leaving a Legacy

Along with successful outreach efforts, CNS-UCSB also flourished when measured by typical academic metrics, including nearly 400 publications and 1,200 talks.

In addition to producing groundbreaking interdisciplinary research, CNS-UCSB also produced innovative educational programs, reaching 200 professionals-in-training from the undergraduate to postdoctoral levels. The Center’s educational centerpiece was a graduate fellowship program, referred to as “magical” by an NSF reviewer, that integrated doctoral students from disciplines across the UCSB campus into ongoing social science research projects.

For social scientists, working side-by-side with science and engineering students gave them an appreciation for the methods, culture, and ethics of their colleagues in different disciplines. It also led to methodological innovation. For their part, scientists and engineers were able to understand the larger context of their work at the bench.

UCSB graduates who participated in CNS’s educational programs have gone on to work as postdocs and professors at universities (including MIT, Stanford, U Penn), policy experts (at organizations like the Science Technology and Policy Institute and the Canadian Institute for Advanced Research), researchers at government agencies (like the National Institute for Standards and Technology), nonprofits (like the Kauffman Foundation), and NGOs. Others work in industry, and some have become entrepreneurs, starting their own businesses.

CNS has spawned lines of research that will continue at UCSB and the institutions of collaborators around the world, but its most enduring legacy will be the students it trained. They bring a true understanding of the complex interconnections between technology and society — along with an intellectual toolkit for examining them — to every sector of the economy, and they will continue to pursue a world that is as just as it technologically advanced.

I found the policy recommendations interesting especially this one:

5.     Although representatives from the nanomaterials industry demonstrate relatively high perceived risk regarding engineered nanomaterials, they likewise demonstrate low sensitivity to variance in risks across type of engineered nanomaterials, and a strong disinclination to regulation. This situation puts workers at significant risk and probably requires regulatory action now (beyond the currently favored voluntary or ‘soft law’ approaches).

Without having read the documents, I’m not sure how to respond but I do have a question.  Just how much regulation are they suggesting?

I offer all of the people associated with the center my thanks for all their hard work and my gratitude for the support I received from the center when I presented at the Society for the Study of Nanotechnologies and Other Emerging Technology (S.Net) in 2012. I’m glad to see they’re going out with a bang.

Nanotechnology-enabled dengue virus vaccine

Here’s news of work-in-progress for a dengue virus vaccine and, possibly, a Zika virus vaccine too. From a Nov. ??, 2016 University of North Carolina news release,

Scientists at the UNC School of Medicine are working to develop a nanoparticle vaccine to protect against the four serotypes of dengue virus, which infects more than 350 million people across the globe each year.

Aravinda de Silva, PhD, professor of microbiology and immunology, and a post-doctoral researcher Stefan Metz, PhD, recently published the latest on their vaccine development efforts in PLOS Neglected Tropical Diseases.

The nanoparticle platform was produced with PRINT (Particle Replication in Non-wetting Templates) technology. Joseph DeSimone, PhD, the Chancellor’s Eminent Professor of Chemistry and a joint professor in the Department of Pharmacology at UNC, developed PRINT, a nano-molding technique, in 2004.

Rather than using a killed or attenuated virus to develop a vaccine for dengue, de Silva’s lab is focusing on “expressing the E protein and attaching it to nanoparticles to induce good immune responses,” Metz said.

The nanoparticle vaccine platform can be safer to certain populations than vaccines that use either live or killed virus, he said.

One of the many complexities about developing a successful dengue vaccine, Metz explained, is that there are four serotypes of the virus, which means researchers need to develop a vaccine that provides immunity against all four serotypes.

“There are currently several vaccines in trial and development for dengue,” Metz said. “One vaccine has gone through all three clinical trial phases and has been licensed in some countries. Although these vaccines produce good antibody responses, a large part of the population still wasn’t protected from each of the serotypes.

“With dengue, you need to vaccinate people against all four serotypes at once in order to protect people. That’s why we’re combing the different serotypes.”

In their most recent study, de Silva and Metz focused their efforts on the second serotype. Now, they’re moving forward with the same studies for serotypes one, three and four.

“In the study, we express the E protein, which is found on the surface of the virus particle,” Metz explained. “This protein is organized in a very complex way, and this complex organization exposes isotopes that are important to induce protective immune response.”

De Silva and Metz were recently named to a global research consortium to tackle Zika, and they’re using the same nanoparticle vaccine platform as they work to develop a Zika vaccine.

“Globally, if you look at the numbers, dengue is still a much bigger problem than Zika,” Metz said, noting that an estimated 25,000 people die from dengue infections each year. “If you get dengue, you might not even notice it. If you do get clinical symptoms during a first infection of dengue, you might feel like you have a feverish flu. A lot of people don’t even know it because if you’re not feeling well for a couple days, you don’t necessarily think that it’s caused by a dengue virus infection.

“However, if you were infected by the first serotype and you had a secondary infection with a different serotype, that’s when the more severe diseases can come up – stress syndromes, hemorrhagic diseases – those can be fatal diseases,” Metz said. “There are thousands and thousands of people dying from those diseases each year.”

Here’s a link to and a citation for the paper,

Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses by Stefan W. Metz, Shaomin Tian, Gabriel Hoekstra, Xianwen Yi, Michelle Stone, Katie Horvath, Michael J. Miley, Joseph DeSimone, Chris J. Luft, Aravinda M. de Silva. PLOS http://dx.doi.org/10.1371/journal.pntd.0005071  Published: October 20, 2016

This paper is open access.