Tag Archives: ETC Group

Sunscreens 2020 and the Environmental Working Group (EWG)

There must be some sweet satisfaction or perhaps it’s better described as relief for the Environmental Working Group (EWG) now that sunscreens with metallic (zinc oxide and/or titanium dioxide) nanoparticles are gaining wide acceptance. (More about the history and politics EWG and metallic nanoparticles at the end of this posting.)

This acceptance has happened alongside growing concerns about oxybenzone, a sunscreen ingredient that EWG has long warned against. Oxybenzone has been banned from use in Hawaii due to environmental concerns (see my July 6, 2018 posting; scroll down about 40% of the way for specifics about Hawaii). Also, it is one of the common sunscreen ingredients for which the US Food and Drug Administration (FDA) is completing a safety review.

Today, zinc oxide and titanium dioxide metallic nanoparticles are being called minerals, as in, “mineral-based” sunscreens. They are categorized as physical sunscreens as opposed to chemical sunscreens.

I believe the most recent sunscreen posting here was my 2018 update (uly 6, 2018 posting) so the topic is overdue for some attention here. From a May 21, 2020 EWG news release (received via email),

As states reopen and Americans leave their homes to venture outside, it’s important for them to remember to protect their skin from the sun’s harmful rays. Today the Environmental Working Group released its 14th annual Guide to Sunscreens.  

This year researchers rated the safety and efficacy of more than 1,300 SPF products – including sunscreens, moisturizers and lip balms – and found that only 25 percent offer adequate protection and do not contain worrisome ingredients such as oxybenzone, a potential hormone-disrupting chemical that is readily absorbed by the body.

Despite a delay in finalizing rules that would make all sunscreens on U.S. store shelves safer, the Food and Drug Administration, the agency that governs sunscreen safety, is completing tests that highlight concerns with common sunscreen ingredients. Last year, the agency published two studies showing that, with just a single application, six commonly used chemical active ingredients, including oxybenzone, are readily absorbed through the skin and could be detected in our bodies at levels that could cause harm.

“It’s quite concerning,” said Nneka Leiba, EWG’s vice president of Healthy Living science. “Those studies don’t prove whether the sunscreens are unsafe, but they do highlight problems with how these products are regulated.”

“EWG has been advocating for the FDA to review these chemical ingredients for 14 years,” Leiba said. “We slather these ingredients on our skin, but these chemicals haven’t been adequately tested. This is just one example of the backward nature of product regulation in the U.S.”

Oxybenzone remains a commonly used active ingredient, found in more than 40 percent of the non-mineral sunscreens in this year’s guide. Oxybenzone is allergenic and a potential endocrine disruptor, and has been detected in human breast milk, amniotic fluid, urine and blood.

According to EWG’s assessment, fewer than half of the products in this year’s guide contain active ingredients that the FDA has proposed are safe and effective.

“Based on the best current science and toxicology data, we continue to recommend sunscreens with the mineral active ingredients zinc dioxide and titanium dioxide, because they are the only two ingredients the FDA recognized as safe or effective in their proposed draft rules,” said Carla Burns, an EWG research and database analyst who manages the updates to the sunscreen guide.

Most people select sunscreen products based on their SPF, or sunburn protection factor, and mistakenly assume that bigger numbers offer better protection. According to the FDA, higher SPF values have not been shown to provide additional clinical benefit and may give users a false sense of protection. This may lead to overexposure to UVA rays that increase the risk of long-term skin damage and cancer. The FDA has proposed limiting SPF claims to 60+.

EWG continues to hone our recommendations by strengthening the criteria for assessing sunscreens, which are based on the latest findings in the scientific literature and commissioned tests of sunscreen product efficacy. This year EWG made changes to our methodology in order to strengthen our requirement that products provide the highest level of UVA protection.

“Our understanding of the dangers associated with UVA exposure is increasing, and they are of great concern,” said Burns. “Sunburn during early life, especially childhood, is very dangerous and a risk factor for all skin cancers, but especially melanoma. Babies and young children are especially vulnerable to sun damage. Just a few blistering sunburns early in life can double a person’s risk of developing melanoma later in life.”

EWG researchers found 180 sunscreens that meet our criteria for safety and efficacy and would likely meet the proposed FDA standards. Even the biggest brands now provide mineral options for consumers.  

Even for Americans continuing to follow stay-at-home orders, wearing an SPF product may still be important. If you’re sitting by a window, UVA and UVB rays can penetrate the glass.  

It is important to remember that sunscreen is only one part of a sun safety routine. People should also protect their skin by covering up with clothing, hats and sunglasses. And sunscreen must be reapplied at least every two hours to stay effective.

EWG’s Guide to Sunscreens helps consumers find products that get high ratings for providing adequate broad-spectrum protection and that are made with ingredients that pose fewer health concerns.

The new guide also includes lists of:

Here are more quick tips for choosing better sunscreens:

  • Check your products in EWG’s sunscreen database and avoid those with harmful ingredients.
  • Avoid products with oxybenzone. This chemical penetrates the skin, gets into the bloodstream and can affect normal hormone activities.
  • Steer clear of products with SPF higher than 50+. High SPF values do not necessarily provide increased UVA protection and may fool you into thinking you are safe from sun damage.
  • Avoid sprays. These popular products pose inhalation concerns, and they may not provide a thick and uniform coating on the skin.
  • Stay away from retinyl palmitate. Government studies link the use of retinyl palmitate, a form of vitamin A, to the formation of skin tumors and lesions when it is applied to sun-exposed skin.
  • Avoid intense sun exposure during the peak hours of 10 a.m. to 4 p.m.

Shoppers on the go can download EWG’s Healthy Living app to get ratings and safety information on sunscreens and other personal care products. Also be sure to check out EWG’s sunscreen label decoder.

One caveat, these EWG-recommended products might not be found in Canadian stores or your favourite product may not have been reviewed for inclusion, as a product to be sought out or avoided, in their database. For example, I use a sunscreen that isn’t listed in the database, although at least a few other of the company’s sunscreen products are. On the plus side, my sunscreen doesn’t include oxybenzone or retinyl palmitate as ingredients.

To sum up the situation with sunscreens containing metallic nanoparticles (minerals), they are considered to be relatively safe but should new research emerge that designation could change. In effect, all we can do is our best with the information at hand.

History and politics of metallic nanoparticles in sunscreens

In 2009 it was a bit of a shock when the EWG released a report recommending the use of sunscreens with metallic nanoparticles in the list of ingredients. From my July 9, 2009 posting,

The EWG (Environmental Working Group) is, according to Maynard [as of 20202: Dr. Andrew Maynard is a scientist and author, Associate Director of Faculty in the ASU {Arizona State University} School for the Future of Innovation in Society, also the director of the ASU Risk Innovation Lab, and leader of the Risk Innovation Nexus], not usually friendly to industry and they had this to say about their own predisposition prior to reviewing the data (from EWG),

When we began our sunscreen investigation at the Environmental Working Group, our researchers thought we would ultimately recommend against micronized and nano-sized zinc oxide and titanium dioxide sunscreens. After all, no one has taken a more expansive and critical look than EWG at the use of nanoparticles in cosmetics and sunscreens, including the lack of definitive safety data and consumer information on these common new ingredients, and few substances more dramatically highlight gaps in our system of public health protections than the raw materials used in the burgeoning field of nanotechnology. But many months and nearly 400 peer-reviewed studies later, we find ourselves drawing a different conclusion, and recommending some sunscreens that may contain nano-sized ingredients.

My understanding is that after this report, the EWG was somewhat ostracized by collegial organizations. Friends of the Earth (FoE) and the ETC Group both of which issued reports that were published after the EWG report and were highly critical of ‘nano sunscreens’.

The ETC Group did not continue its anti nanosunscreen campaign for long (I saw only one report) but FoE (in particular the Australian arm of the organization) more than made up for that withdrawal and to sad effect. My February 9, 2012 post title was this: Unintended consequences: Australians not using sunscreens to avoid nanoparticles?

An Australian government survey found that 13% of Australians were not using any sunscreen due to fears about nanoparticles. In a country with the highest incidence of skin cancer in the world and, which spent untold millions over decades getting people to cover up in the sun, it was devastating news.

FoE immediately withdrew all their anti nanosunscreen materials in Australia from circulation while firing broadsides at the government. The organization’s focus on sunscreens with metallic nanoparticles has diminished since 2012.

Research

I have difficulty trusting materials from FoE and you can see why here in this July 26, 2011 posting (Misunderstanding the data or a failure to research? Georgia Straight article about nanoparticles). In it, I analyze Alex Roslin’s profoundly problematic article about metallic nanoparticles and other engineered nanoparticles. All of Roslin’s article was based on research and materials produced by FoE which misrepresented some of the research. Roslin would have realized that if he had bothered to do any research for himself.

EWG impressed me mightily with their refusal to set aside or dismiss the research disputing their initial assumption that metallic nanoparticles in sunscreens were hazardous. (BTW, there is one instance where metallic nanoparticles in sunscreens are of concern. My October 13, 2013 posting about anatase and rutile forms of titanium dioxide at the nanoscale features research on that issue.)

EWG’s Wikipedia entry

Whoever and however many are maintaining this page, they don’t like EWG at all,

The accuracy of EWG reports and statements have been criticized, as has its funding by the organic food industry[2][3][4][5] Its warnings have been labeled “alarmist”, “scaremongering” and “misleading”.[6][7][8] Despite the questionable status of its work, EWG has been influential.[9]

This is the third paragraph in the Introduction. At its very best, the information is neutral, otherwise, it’s much like that third paragraph.

Even John D. Rockeller’s entry is more flattering and he was known as the ‘most hated man in America’ as this show description on the Public Broadcasting Service (PBS) website makes clear,

American Experience

The Rockefellers Chapter One

Clip: Season 13 Episode 1 | 9m 37s

John D. Rockefeller was the world’s first billionaire and the most hated man in America. Watch the epic story of the man who monopolized oil.

Fun in the sun

Have fun in the sun this summer. There’s EWG’s sunscreen database, the tips listed in the news release, and EWG also has a webpage where they describe their methodology for how they assess sunscreens. It gets a little technical (for me anyway) but it should answer any further safety questions you might have after reading this post.

It may require a bit of ingenuity given the concerns over COVID-19 but I’m constantly amazed at the inventiveness with which so many people have met this pandemic. (This June 15, 2020 Canadian Broadcasting Corporation article by Sheena Goodyear features a family that created a machine that won the 2020 Rube Goldberg Bar of Soap Video challenge. The article includes an embedded video of the winning machine in action.)

Get better protection from a sunscreen with a ‘flamenco dancing’ molecule?

Caption: illustrative image for the University of Warwick research on ‘Flamenco dancing’ molecule could lead to better-protecting sunscreen created by Dr. Michael Horbury. Credit:: created by Dr Michael Horbury

There are high hopes (more about why later) for a plant-based ‘flamenco dancing molecule’ and its inclusion in sunscreens as described in an October 18, 2019 University of Warwick press release (also on EurekAlert),

A molecule that protects plants from overexposure to harmful sunlight thanks to its flamenco-style twist could form the basis for a new longer-lasting sunscreen, chemists at the University of Warwick have found, in collaboration with colleagues in France and Spain. Research on the green molecule by the scientists has revealed that it absorbs ultraviolet light and then disperses it in a ‘flamenco-style’ dance, making it ideal for use as a UV filter in sunscreens.

The team of scientists report today, Friday 18th October 2019, in the journal Nature Communications that, as well as being plant-inspired, this molecule is also among a small number of suitable substances that are effective in absorbing light in the Ultraviolet A (UVA) region of wavelengths. It opens up the possibility of developing a naturally-derived and eco-friendly sunscreen that protects against the full range of harmful wavelengths of light from the sun.

The UV filters in a sunscreen are the ingredients that predominantly provide the protection from the sun’s rays. In addition to UV filters, sunscreens will typically also include:

Emollients, used for moisturising and lubricating the skin
Thickening agents
Emulsifiers to bind all the ingredients
Water
Other components that improve aesthetics, water resistance, etc.

The researchers tested a molecule called diethyl sinapate, a close mimic to a molecule that is commonly found in the leaves of plants, which is responsible for protecting them from overexposure to UV light while they absorb visible light for photosynthesis.

They first exposed the molecule to a number of different solvents to determine whether that had any impact on its (principally) light absorbing behaviour. They then deposited a sample of the molecule on an industry standard human skin mimic (VITRO-CORNEUM®) where it was irradiated with different wavelengths of UV light. They used the state-of-the-art laser facilities within the Warwick Centre for Ultrafast Spectroscopy to take images of the molecule at extremely high speeds, to observe what happens to the light’s energy when it’s absorbed in the molecule in the very early stages (millionths of millionths of a second). Other techniques were also used to establish longer term (many hours) properties of diethyl sinapate, such as endocrine disruption activity and antioxidant potential.

Professor Vasilios Stavros from the University of Warwick, Department of Chemistry, who was part of the research team, explains: “A really good sunscreen absorbs light and converts it to harmless heat. A bad sunscreen is one that absorbs light and then, for example, breaks down potentially inducing other chemistry that you don’t want. Diethyl sinapate generates lots of heat, and that’s really crucial.”

When irradiated the molecule absorbs light and goes into an excited state but that energy then has to be disposed of somehow. The team of researchers observed that it does a kind of molecular ‘dance’ a mere 10 picoseconds (ten millionths of a millionth of a second) long: a twist in a similar fashion to the filigranas and floreos hand movements of flamenco dancers. That causes it to come back to its original ground state and convert that energy into vibrational energy, or heat.

It is this ‘flamenco dance’ that gives the molecule its long-lasting qualities. When the scientists bombarded the molecule with UVA light they found that it degraded only 3% over two hours, compared to the industry requirement of 30%.

Dr Michael Horbury, who was a Postgraduate Research Fellow at The University Warwick when he undertook this research (and now at the University of Leeds) adds: “We have shown that by studying the molecular dance on such a short time-scale, the information that you gain can have tremendous repercussions on how you design future sunscreens.
Emily Holt, a PhD student in the Department of Chemistry at the University of Warwick who was part of the research team, said: “The next step would be to test it on human skin, then to mix it with other ingredients that you find in a sunscreen to see how those affect its characteristics.”

Professor Florent Allais and Dr Louis Mouterde, URD Agro-Biotechnologies Industrielles at AgroParisTech (Pomacle, France) commented: “What we have developed together is a molecule based upon a UV photoprotective molecule found in the surface of leaves on a plant and refunctionalised it using greener synthetic procedures. Indeed, this molecule has excellent long-term properties while exhibiting low endocrine disruption and valuable antioxidant properties.”

Professor Laurent Blasco, Global Technical Manager (Skin Essentials) at Lubrizol and Honorary Professor at the University of Warwick commented: “In sunscreen formulations at the moment there is a lack of broad-spectrum protection from a single UV filter. Our collaboration has gone some way towards developing a next generation broad-spectrum UV filter inspired by nature. Our collaboration has also highlighted the importance of academia and industry working together towards a common goal.”

Professor Vasilios Stavros added, “Amidst escalating concerns about their impact on human toxicity (e.g. endocrine disruption) and ecotoxicity (e.g. coral bleaching), developing new UV filters is essential. We have demonstrated that a highly attractive avenue is ‘nature-inspired’ UV filters, which provide a front-line defence against skin cancer and premature skin aging.”

Here’s a link to and a citation for the paper,

Towards symmetry driven and nature inspired UV filter design by Michael D. Horbury, Emily L. Holt, Louis M. M. Mouterde, Patrick Balaguer, Juan Cebrián, Laurent Blasco, Florent Allais & Vasilios G. Stavros. Nature Communications volume 10, Article number: 4748 (2019) DOI: https://doi.org/10.1038/s41467-019-12719-z

This paper is open access.

Why the high hopes?

Briefly (the long story stretches over 10 years), the most recommended sunscreens today (2020) are ‘mineral-based’. This is painfully amusing because civil society groups (activists) such as Friends of the Earth (in particular the Australia chapter under Georgia Miller’s leadership) and Canada’s own ETC Group had campaigned against these same sunscreen when they were billed as being based on metal oxide nanoparticles such zinc oxide and/or titanium oxide. The ETC Group under Pat Roy Mooney’s leadership didn’t press the campaign after an initial push. As for Australia and Friend of the Earth, their anti-metallic oxide nanoparticle sunscreen campaign didn’t work out well as I noted in a February 9, 2012 posting and with a follow-up in an October 31, 2012 posting.

The only civil society group to give approval (very reluctantly) was the Environmental Working Group (EWG) as I noted in a July 9, 2009 posting. They had concerns about the fact that these ingredients are metallic but after a thorough of then available research, EWG gave the sunscreens a passing grade and noted, in their report, that they had more concerns about the use of oxybenzone in sunscreens. That latter concern has since been flagged by others (e.g., the state of Hawai’i) as noted in my July 6, 2018 posting.

So, rebranding metallic oxides as minerals has allowed the various civil society groups to support the very same sunscreens many of them were advocating against.

In the meantime, scientists continue work on developing plant-based sunscreens as an improvement to the ‘mineral-based’ sunscreens used now.

Canadian science and society symposium in Ottawa (Oct. 21 – 23, 2013)

The Science and Society 2013: Emerging Agendas for Citizens and the Sciences symposium (featured previously in my Aug. 16,, 2013 posting) is being held in Ottawa, Ontario from Oct. 21-23, 2013 according to the symposium homepage,

Co-organized by the Situating Science SSHRC Strategic Knowledge Cluster (www.situsci.ca) and the University of Ottawa’s Institute for Science, Society and Policy (www.issp.uottawa.ca), the Science and Society 2013 symposium aims to understand and address the key issues at the interface of science, technology, society and policy.

The event will connect disparate themes and bring different groups with shared interests together to brainstorm solutions to common challenges. It will demonstrate that collaboration among academics, students, policy makers, stakeholders and the public at large can lead to new insights and a deeper understanding of the social and cultural contexts of science and technology.

The symposium aims to make the discussion of science and technology and their place in society more prominent in the national dialogue, notably through the publication of a symposium report containing recommendations on how to understand and improve the science-society interface and improve science policy.  This document will be distributed among media and key decision makers.

There are three events for the public:

The Transformations in the Relations Between Science, Policy and Citizens

Date: Mon. Oct. 21, 2013
Time: 19:00 – 20:30
Location: Desmarais Building, Rm. 12-102 (12th floor), University of Ottawa, 55 Laurier Avenue East, Ottawa
Price: Free (registration required)
Reception and Student Poster Display to follow
Out of town? Watch live online (link TBD)

The traditional relations between scientists, policy makers and citizens have been transformed over the last fifteen years. Scientists were used to providing science for policy makers who were eager to listen, while citizens were relatively confident in the judgments of scientists. Using recent cases of scientific and public controversies, we will show that citizens have more power now than ever before to influence policies in matters relating to scientific research. This raises the pressing issue for us as citizens: How do we give a central place to a scientific culture that is adapted to the 21st century?

Yves Gingras
Canada Research Chair in the History and Sociology of Science
Université du Québec à Montréal

UNCERTAIN SCIENCE, UNCERTAIN TIMES
Selections and discussion of Michael Frayn’s Tony Award-winning play, Copenhagen
Moderated by Jay Ingram
Directed by Kevin Orr
Tuesday Oct. 22, 2013, 7:30 pm
Alumni Auditorium, Jock-Turcot University Centre, 85 University, University of Ottawa
Free
Donations accepted at the door
Reception to follow
“Join” our Facebook event page:
https://www.facebook.com/events/455270781259464/?ref=22Limited seating!  Register online by Sunday Oct. 20:
www.ScienceAndSociety2013.ca    

The Situating Science national Strategic Knowledge Cluster with the University of Ottawa Institute for Science, Society and Policy invite you to join us for a professionally staged reading of selections from Michael Frayn’s acclaimed play Copenhagen, which will be interwoven with expert panel discussions moderated by science broadcaster and author, Jay Ingram.

Copenhagen is based on the final meeting of Nobel-Prize winning physicists Niels Bohr and Werner Heisenberg in the midst of the 1940s War effort. The issues it raises concerning science, ethics and politics are as pressing as ever.

Stage readings by: Tibor Egervari, Peter Hawaorth, and Beverly Wolfe

Panelists:
Dr. Ted Hsu, Member of Parliament for Kingston and the Islands, Science and Technology Critic for the Liberal Party of Canada

Dr. Shohini Ghose, Associate Professor, Department of Physics & Computer Science; Affiliate member, Perimeter Institute for Theoretical Physics and Director, Centre for Women in Science, Wilfred Laurier University

Dr. Robert Smith, Professor, Department of History and Classics, University of Alberta

Influencers Panel
Panel of influential decision-makers discussing results of the symposium

Date: Wed. Oct. 23, 2013
Time: 17:30 – 19:00
Location: Desmarais Building, Rm. 12-102 (12th floor), University of Ottawa, 55 Laurier Avenue East, Ottawa
Price: Free (registration required)
Reception to follow.
Out of town? Watch live online! (link TBD)

Yves St-Onge
Vice-President, Public Affairs and Marketing, Canada Science and Technology Museums Corporation

Scott Findlay
Associate Professor, Department of Biology, University of Ottawa
Evidence for Democracy

Pat Mooney
Executive Director, ETC Group

Louise Vandelac
Professor, Department of Sociology, Université du Québec à Montréal

Denise Amyot
President and CEO, Association of Canadian Community Colleges

Register today to attend the 3 public evening events …
Not in Ottawa? Some select symposium events will be availble to watch online live (no registration needed). Stay tuned to the event website for more.

This symposium, save for the three public evening events, appears to be for invitees only (there’s no symposium registration page). Presumably nobody wants any members of the public or strangers present when the invitees discuss such topics as these (from the symposium programme):

Science and Its Publics: Dependence, Disenchantment, and Deliverance [emphasis mins]

Desmarais Building Rm. 12
102
Chair: Dr. Gordon McOuat, Situating Science
Speaker: Dr. Sheila Jasanoff, Harvard Kennedy School
Session 1a: Science and Democracy [emphasis mine]
Desmarais Building Rm. 12
102
Chair/Speaker: Dr. Heather Douglas, Waterloo
Speakers:
Dr. Frédéric Bouchard, U. de Montréal
Dr. Patrick Feng, U. Calgary
Science, Policy and Citizens: How to improve the Science/Society interface [emphasis mine]
Desmarais Building Rm. 12 – 102
Chairs: Dr. Marc Saner, ISSP and Dr. Gordon McOuat, Situating Science
Speakers: Rapporteurs from previous sessions

It seems odd to be discussing democracy, citizenship, and science without allowing the public to attend any of the sessions. Meanwhile, the symposium’s one and only science and media session features two speakers, Penny Park of the Science Media Centre of Canada and Ivan Semeniuk of the Globe and Mail, who are firmly ensconced members of the mainstream media with no mention of anything else (science blogs?). Arguably, science bloggers could be considered relevant to these discussions since research suggests that interested members of the public are searching for science information online (in blogs and elsewhere) in in increasing numbers. I hope to get a look at the documentation once its been published, assuming there will be public access.

Plants that glow in the dark; Kickstarter campaign or public relations campaign?

Synthetic biologists have set up a Kickstarter campaign, Glowing Plants: Natural Lighting with no Electricity, designed to raise funds for a specific project and enthusiasm for  synthetic biology in the form of plants that glow in the dark. As of this morning (May 7, 2013, 9:50 am PDT), the campaign has raised $248, 600. They’ve met their initial goal of $60,000 and are now working towards their stretch goal of $400,000 with 30 days left.

Glowing Arabidopsis

Glowing Arabidopsis

Ariel Schwartz in her May 7, 2013 article for Fast Company describes the project this way,

Based on research from the University of Cambridge and the State University of New York, the Glowing Plants campaign promises backers that they’ll receive seeds to grow their own glowing Arabidopsis plants at home. If the campaign reaches its $400,000 stretch goal, glowing rose plants will also become available.

“We wanted to test the idea of whether there is demand for synthetic biology projects,” explains project co-founder Antony Evans. …

Kickstarter backers will get seeds created using particle bombardment. Gold nano-particles coated with a DNA construct developed by the team are fired at plant cells at a high-velocity. A small number of those particles make it into the Arabidopsis plant cells, where they’re absorbed into the plant chromosomes.

Arabidopsis was chosen for a number of reasons: it’s not native to the U.S., so there is little risk of cross-pollination; it doesn’t survive well in the wild (again, reducing risk of cross-pollination), it self-pollinates, and up until recently, it was thought to have the shortest genome of any plant. That means the protocols for Arabidopsis plant transformation work are well-established. Roses (the stretch goal plant) have also been studied extensively, and they carry little risk of cross-pollination, according to Evans.

As Schwartz notes, the project has potential for future applications,

In the meantime, Evans and his team plan on spending the next year on the campaign. Eventually, Evans imagines that the Glowing Plants creators will work on bigger glowing plant species, so one day they could even be used for street lighting.

Here’s more about the team behind this Kickstarter campaign (from the project page, click on Antony Evans),

Omri Amirav-Drory, PhD, is the founder and CEO of Genome Compiler, a synthetic biology venture. Prior to starting his company, Omri was a Fulbright postdoctoral research fellow at Stanford University School of Medicine and HHMI, performing neuroscience research using structural and synthetic biology methods. Omri received his PhD in biochemistry from Tel-Aviv University for biochemical and structural studies of membrane protein complexes involved in bio-energetics.

Antony Evans has an MBA with Distinction from INSEAD, an MA in Maths from the University of Cambridge and is a graduate of Singularity University’s GSP program. He is both a Louis Frank and Oppidan scholar and worked for six years as a management consultant and project manager at Oliver Wyman and Bain & Company. Prior to this project he co-founded the world’s first pure mobile microfinance bank in the Philippines and launched a mobile app in partnership with Harvard Medical School.

Kyle Taylor was born and raised in the great state of Kansas, where his love of plants evolved out of an interest in the agriculture all around him. This lead him to major in Agriculture Biochemistry and minor in Agronomy at Iowa State University and then pursue a PhD in Cell and Molecular Biology at Stanford University. Not too bad for a rural country boy! Since a lot of people helped him get to this point, he’s driven to share his passion and excitement by making what he does more accessible. Kyle teaches Introduction to Molecular Cell Biology at Biocurious and is our resident plant expert.

This project reminded me of artist Eduardo Kac (pronounced Katz) and his transgenic bunny, Alba. She glows/ed green in the dark. Here’s more from Kac’s ‘transgenic bunny’ webpage,

My transgenic artwork “GFP Bunny” comprises the creation of a green fluorescent rabbit, the public dialogue generated by the project, and the social integration of the rabbit. GFP stands for green fluorescent protein. “GFP Bunny” was realized in 2000 and first presented publicly in Avignon, France. Transgenic art, I proposed elsewhere [1], is a new art form based on the use of genetic engineering to transfer natural or synthetic genes to an organism, to create unique living beings. This must be done with great care, with acknowledgment of the complex issues thus raised and, above all, with a commitment to respect, nurture, and love the life thus created.

Alba, the fluorescent bunny. Photo: Chrystelle Fontaine

Alba, the fluorescent bunny. Photo: Chrystelle Fontaine

She never looks quite real to me. Under a standard light, she’s a white rabbit but glows when illuminated by a blue  light.  From Kac’s transgenic bunny page,

She was created with EGFP, an enhanced version (i.e., a synthetic mutation) of the original wild-type green fluorescent gene found in the jellyfish Aequorea Victoria. EGFP gives about two orders of magnitude greater fluorescence in mammalian cells (including human cells) than the original jellyfish gene

I don’t know if she still lives but Kac was creating work based on her up until 2011. You can find more here.

ETA June 12, 2013:  Anya Kamenetz has written a followup June 12, 2013 article for Fast Company about this Kickstarter project (Note: A link has been removed),

Though the project is technically legal, its sheer hubris has kickstarted some serious from scientists and environmental groups that object to the release of these seeds to the public, with the chance that the DNA will get into the natural gene pool with unknown consequences. An anti-synthetic bio group called ETC has started a fundraising drive of their own, dubbed a “Kickstopper.”

There’s also an online petition according to Kamenetz. One comment, her description of ‘ETC’ as an anti-synthetic bio group doesn’t quite convey the group’s scope or depth. It’s name is the ETC Group (Action group on Erosion, Technology and Concentration) and its tag line is ‘monitoring power, tracking technology, strengthening diversity.

ETA August 16, 2017: I have an update for the Kickstarter project and additional information about Alba in an Aug. 16, 201 posting.

ETC group replies to Nature’s “Nanotechnology: Armed resistance” article

In late August 2012, Nature ran an open access article about terrorism used to fight nanotechnology research, “Nanotechnology: Armed resistance,” where more ‘moderate’ activist groups such as the ETC Group (Action Group on Erosion, Technology and Concentration) were implicated. From my Aug. 31, 2012 posting about the Aug. 30, 2012 Nature article by Leigh Phillips,

Phillips’ article goes on to discuss some of the more moderate groups including the Canada-based ETC Group, which has an office in Mexico,

Some researchers in Mexico say that more-moderate groups are stoking fears about nanotechnology. One such body is the Action Group on Erosion, Technology and Concentration (ETC, pronounced et cetera), a small but vocal non-profit organization based in Ottawa, Canada, which was one of the first to raise concerns about nanotechnology and has to a large extent framed the international discussion. Silvia Ribeiro, the group’s Latin America director, based in Mexico City, says that the organization has no links to the ITS.

….

When you analyze it, Phillips’ article is just as emotionally manipulative as the ETC Group’s communications. Including the ETC Group with the eco-anarchists in an article about terrorism and nanotechnology is equivalent to including the journal Nature with North Korea in an article about right-wing, repressive institutions framed from beginning to end to prove a somewhat elusive point.

Silvia Ribeiro, Latin America director of the ETC Group who is based in Mexico City, has replied in a letter to Nature published Oct. 4, 2012, which is behind a paywall. From Ribeiro’s letter (Note: I have removed a link),

You contend that most nanotechnology researchers now acknowledge that some areas of their work raise legitimate environmental, health and safety concerns (Nature 488, 576-579; 2012). …

In 2002, scientists could point us to only one peer-reviewed study of nanotube toxicity, and companies were still sending a Material Safety Data Sheet for graphite with carbon nanotube shipments. ETC’s concerns were dismissed as alarmist. We welcome the change in attitude.

While I’m not convinced that the reason for the scarcity of safety research was due to a huge majority of the scientific community being blind to possible health and environmental issues (perhaps there were other reasons for the lack of nanotoxicity research?) as Ribeiro implies, she does make a telling point here and elsewhere in her letter. I do find it a bit strange that this letter is behind a paywall when the article is open access; it seems like preferential treatment for one point of view and I expect better of Nature and its editors.

In depth and one year later—the nanotechnology bombings in Mexico

Last year in an Aug. 11, 2011 post I covered some stories about terrorism and nanotechnology in the aftermath of a major bombing in Mexico where two scientists were injured. Leigh Phillips has written a substantive news feature focusing largely on the situation in Mexico.

From the Aug. 29, 2012 news feature (open access) in the journal Nature,

Nature assesses the aftermath of a series of nanotechnology-lab bombings in Mexico — and asks how the country became a target of eco-anarchists.

The shoe-box-sized package was addressed to Armando Herrera Corral. It stated that he was the recipient of an award and it was covered in official-looking stamps. Herrera, a computer scientist at the Monterrey Institute of Technology and Higher Education in Mexico City, shook the box a number of times, and something solid jiggled inside. What could it be? He was excited and a little nervous — so much so, that he walked down the hall to the office of a colleague, robotics researcher Alejandro Aceves López, and asked Aceves to open it for him.

Aceves sat down at his desk to tear the box open. So when the 20-centimetre-long pipe bomb inside exploded, on 8 August 2011, Aceves took the full force in his chest. Metal pierced one of his lungs. “He was in intensive care. He was really bad,” says Herrera’s brother Gerardo, a theoretical physicist at the nearby Centre for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav). Armando Herrera Corral, who was standing nearby when the bomb went off, escaped with a burst eardrum and burns to his legs.

As was reported at the time, an eco-anarchist group calling itself ‘Individuals Tending Towards (or To) Savagery’ laid claim to this ‘achievement’.

While there have been attacks elsewhere*, Mexico has experienced more attacks and more violence and the impact is being felt personally and institutionally,

One year on from the bombing at Monterrey Tec, the repercussions are still being felt. Armando Herrera Corral and Aceves will not speak to Nature about what happened. “It’s too sensitive, you understand?” is all Aceves would say. Herrera has left his job as director of the university’s technology park and is now head of postgraduate studies. Other Mexican universities with nanotechnology research programmes have evacuated campuses in response to bomb threats, and universities across the country have introduced stringent security measures. Some researchers are anxious for their own safety; some are furious about being targets. But all the researchers that Nature spoke to in Mexico are adamant that the attacks will not discourage them from their research or dissuade students from entering the field.

As for reasons why Mexico, to date, has experienced more attacks than other countries,

Reporting by Nature suggests that several broad trends have come together to precipitate the violence. Over the past decade, Mexico has invested heavily in nanotechnology relative to other developing countries, because it sees the field as a route to economic development; mainstream green groups worldwide have grown increasingly concerned about nanotechnology’s health and environmental risks; and there has been a shift towards extreme ideas and tactics among radical environmentalists critical of technology. In Mexico, this has been set against a general background of growing violence and political upheaval.

According to Phillips’ article there were three incidents in 2011 (April, May, and August, respectively)  in Mexico as compared to one attempted attack in Switzerland in 2010. This year, there has been one attack in Europe as I noted in my May 29, 2012 post which featured Andy Coghlan’s article for New Scientist on rising violence against scientists. From Coghlan’s article,

It’s like something out of Kafka. Anti-science anarchists in Italy appear to be ramping up their violent and frankly surreal campaign. Having claimed responsibility for shooting the boss of a nuclear engineering company in Genoa, the group has vowed to target Finmeccanica, the Italian aerospace and defence giant.

In  a diatribe sent on 11 May to Corriere della Sera newspaper on 11 May, the Olga Cell of the Informal Anarchist Federation International Revolutionary Front said it shot Roberto Adinolfi, head of Ansaldo Nucleare, in the leg four days earlier. “With this action of ours, we return to you a tiny part of the suffering that you, man of science, are pouring into this world,” the statement said. It also pledged a “campaign of struggle against Finmeccanica, the murderous octopus”.

Coghlan suggests that the focus is being shifted from nanotechnology to nuclear science in the wake of Japan’s Fukushima nuclear accident in 2011.

Philips takes a different tack in the Nature article,

As nanotechnology has been growing in Latin America, a violent eco-anarchist philosophy has taken root among certain radical groups in Mexico. Mexican intelligence services believe that the perpetrators of the bombings last year were mainly young and well educated: their communiqués are littered with references to English-language texts unlikely to have been translated into Spanish.[emphasis mine] Intelligence services say that the eco-anarchist groups have been around for about a decade. They started off protesting against Mexico’s economic and political system by setting off small explosives that destroyed bank machines.But around 2008, certain groups began to adopt an ‘anarcho-primitivist’ perspective. (Locally, they are called primativistas, says Gerardo Herrera Corral.) This philosophy had won little notice until the past few years, but with increasing media reports of looming global climate disaster, some radical green activists have latched on to it. California-based environmental writer Derrick Jensen — whose popular books call for an underground network of ‘Deep Green Resistance’ cells — is a highly influential figure in this otherwise leaderless movement, which argues that industrial civilization is responsible for environmental destruction and must be dismantled.

In their writings, anarcho-primitivist groups often express deep anxiety about a range of advanced research subjects, including genetic engineering, cloning, synthetic biology, geoengineering and neurosciences. But it is nanotechnology, a common subject for science-fiction doomsday scenarios, that most clearly symbolizes to them the power of modern science run amok. “Nanotechnology is the furthest advancement that may yet exist in the history of anthropocentric progress,” the ITS wrote in its first communiqué, in April 2011.

If the perpetrators are young and well-educated then the comment in this excerpt from the article does not follow logically and Phillips does not explain this seeming disparity,

In Mexico, the existing social and political climate may have helped light the fuse, says Miguel Méndez Rojas, coordinator of the department of nanotechnology and molecular engineering at the University of the Americas Puebla in Mexico. He says that the bombings cannot be understood outside the context of what he describes as a dangerous cocktail of poverty and poor education, widespread ignorance of science, ongoing social upheaval and a climate of violence. [emphasis mine]

Phillips’ article goes on to discuss some of the more moderate groups including the Canada-based ETC Group, which has an office in Mexico,

Some researchers in Mexico say that more-moderate groups are stoking fears about nanotechnology. One such body is the Action Group on Erosion, Technology and Concentration (ETC, pronounced et cetera), a small but vocal non-profit organization based in Ottawa, Canada, which was one of the first to raise concerns about nanotechnology and has to a large extent framed the international discussion. Silvia Ribeiro, the group’s Latin America director, based in Mexico City, says that the organization has no links to the ITS. The bombings were a “sick development”, she says. “These kinds of attacks — they are benefiting the development of nanotechnology,” she says. “It polarized the discussion. Do you want nanotech or the bomb?”

ETC wants to see a moratorium on all nanotechnology research, says Ribeiro, who is the lead author on many of the group’s reports criticizing nanotechnology research and commercialization. She says that there have not been enough toxicological studies on engineered nanoparticles, and that no government has developed a regulatory regime that explicitly addresses risk at the nanoscale.

However, ETC also infuriates researchers by issuing warnings of a more speculative nature. For example, it has latched on to the concept of ‘grey goo’ — self-replicating nanorobots run wild — that was raised in the book Engines of Creation (Doubleday, 1986) by nanotechnology engineer Eric Drexler. In ETC’s primer on nanoscale technologies, it says that the “likely future threat is that the merger of living and non-living matter will result in hybrid organisms and products that are not easy to control and behave in unpredictable ways”.

Ribeiro has also criticized genetic modification and vaccination against human papillomavirus in a weekly column in La Jornada. Méndez Rojas says that ETC “promotes beliefs, but they are not based on facts, and we need a public discussion of the facts”.

The impression I’ve had from reading ETC materials is that they are trying to repeat the success they enjoyed with the GMO (genetically modified organisms) and frankenfood campaign and they’d dearly love to whip up some strong feelings about nanotechnology in aid of more regulation.

I’m not a big ETC fan but I do have to note that their research is solid, once you get past the annoying ‘smart ass’ or juvenile attitude in the literature. Yes, they have an agenda but that’s standard. Everyone has an agenda so you always have to check more than one source.  When you analyze it, Phillips’ article is just as emotionally manipulative as the ETC Group’s communications. Including the ETC Group with the eco-anarchists in an article about terrorism and nanotechnology is equivalent to including the journal Nature with North Korea in an article about right-wing, repressive institutions framed from beginning to end to prove a somewhat elusive point.

Scientists in general seem to recognize that there are some legitimate concerns being expressed by the ETC Group and others,

Most nanotechnology researchers acknowledge that some areas of their work raise legitimate environmental, health and safety concerns. The most important response, says Gerardo Herrera Corral, is for scientists to engage with the public to address and dispel concerns. Herrera is head of Mexico’s only experiment at CERN, Europe’s particle-physics laboratory near Geneva, Switzerland, and he points to how CERN dealt with public fears that its Large Hadron Collider could create a black hole that would swallow Earth. “We set up a committee to deal with this. We looked into the real dangers. There were journal articles and we answered all the e-mails we got from people. I mean top-level physicists answering thousands of e-mails.”

“But this is work we should all be doing,” says Herrera. “Even if it’s extra work on top of all the other things we have to do. It’s just part of our job now.”

I like the idea of high level scientists taking the time to answer my questions and I imagine others feel the same way, which may go a long way in explaining why CERN (European Particle Physics Laboratory) has acquired such good will internationally.

Overall, I suspect Phillips is a little over-invested in Mexico’s nanotechnology terrorism. Three incidents in one year suggests something deeply disturbing (and devastating if you are the target) but in an international context, there were only three incidents. If you add up all of the nanotechnology incidents cited in Phillips’ article, there are three bombings (Mexico), one attempted bombing (Switzerland), a successful arson attempt (Mexico), and a few cancelled public debates (France) from 2009 – Fall 2012.

I am inclined to Coghlan’s argument that there is a disturbing trend toward anti-science violence and, it seems to me, it is largely unfocused, nanotechnology here, nuclear science there, biotechnology everywhere, and who knows what else or where else next?

ETA Feb. 21, 2013: Leigh Phillips contacted me to mention that there was a May 28, 2012 article for Nature, Anarchists attack science, which preceded Coghlan’s article for New Scientist and to which Coghlan provides a link. Phillips’ preceding article was subtitled, Armed extremists are targeting nuclear and nanotechnology workers. Phillips opens with the then recent attack on a nuclear engineering executive and subsequently focuses on attacks in the nanotechnology sector.

* ‘While there have been other attacks ‘ changed to ‘While there have been attacks elsewhere’, on Aug. 9, 2015.

Sort of secret summit for international nanotechnology activists

Apparently, global activists are meeting for the 4th International Nanotechnology Activist Summit in Berlin, Oct. 6 – 7, 2011. I did a quick search and was unable to find a website for the summit or find any additional information about it on the Friends of the Earth nano website or the ETC Group website, both represented at the summit. The source for the Oct. 7, 2011 news item on Nanowerk is the European Environmental Bureau (one of the activist groups at the Summit). From the news item on Nanowerk,

Some 30 activists representing 14 environmental, technology assessment and consumer organisations from Europe, the United States, Canada and Latin America met for the 4th International Nanotechnology Activist Summit in Berlin on October 6 and 7.

Jaydee Hanson from the International Center for Technology Assessment, which has filed legal challenges to the US Environmental Policy Agency and the Food and Drug Administration, called “for the protection of workers and the public from exposure to nanomaterials that have not been proven safe.”

Paolo Martins, Coordinator of the Brazilian Research Network in Nanotechnology, Society and the Environment called for review of nanotechnologies that will have wide-ranging effects on workers and consumers in the developing world. He noted that there must be, “full consideration of the ethical and social impacts of these technologies.”

Ian Illuminato of Friends of the Earth [FoE]-US demanded that “a full lifecycle analysis must be completed prior to any commercialization of nano-products.” [emphasis mine]

Dorothée Browaeys, Director General of VivAgora (France) noted that “nanomaterials must be classified as new substances and subject to nano-specific regulation. France has initiated mandatory declaration for producers and importers, this should be expanded to include all formulators and retailers of products containing nanomaterials. Other countries should do likewise.”

Pat Mooney, Executive Director of the ETC Group, with offices in Canada, the Philippines, Mexico, and the US called for a moratorium on the commercialization of nano-products, but noted that all “Nano-industries must be fully accountable for liabilities caused by their products if they come on the market.”

Given the carbon footprint from the travel for these 14 individuals, these quotes seem like fairly standard rhetoric. I hope there’s more news forthcoming from this meeting otherwise it would seem to be a waste of time and resources.

As for Ian Illuminato (what a marvelous name!), I’m surprised he heads up the FoE-US arm of the organization since, according to a July 21, 2011 news article by Alex Roslin for Vancouver’s (Canada) Georgia Straight, Illuminato has a “home office in Victoria (Canada).” Is this a new trend? Live in Canada and head up a US organization? Note: I wrote a commentary about Roslin’s article on nanoparticles in my July 26, 2011 posting.

Precautionary principle and the new Swiss synthetic nanomaterial matrix

The precautionary principle appears to be much loved by civil society groups such the ETC Group and Friends of the Earth. They tend to cite it with some frequency as a means of managing scientific research or, as some might suggest, as a means of stopping research. I have to admit I’ve tended to view the precautionary principle as a way of saying ‘don’t do anything unless you can prove it’s safe’, and that is a gross misunderstanding of the principle. The recent announcement from Switzerland about developing a precautionary matrix for synthetic nanomaterials had me revisiting my ideas.

I found this description of the principle in a July 18, 2010 posting about nanosunscreens by Andrew Mayanard on his 2020 Science blog,

The Precautionary Principle is one approach – and a very misunderstood and misused one – to addressing this [risk and uncertainty], and one brought up by FoE and others in the context of sunscreens.  It has many formulations – it’s not a hard and fast principle.  But it is currently described in the European Union in this way:

The precautionary principle should be informed by three specific principles:

  • implementation of the principle should be based on the fullest possible scientific evaluation. As far as possible this evaluation should determine the degree of scientific uncertainty at each stage;
  • any decision to act or not to act pursuant to the precautionary principle must be preceded by a risk evaluation and an evaluation of the potential consequences of inaction;
  • once the results of the scientific evaluation and/or the risk evaluation are available, all the interested parties must be given the opportunity to study of the various options available, while ensuring the greatest possible transparency.

This is a pragmatic principle that looks to using evidence and an evaluation of consequences in making informed decisions in the face of uncertainty.  It certainly does not preclude the development or implementation of a new technology until there is certainty on safety.

The emphasis on the potential consequences of inaction are particularly relevant to today’s world, where we are stuck on a technological tight-rope, and where the consequences of not doing something may be more harmful than taking action. [emphasis mine]  Richard Jones [author Soft Machines and a Professor of Physics and the Pro-Vice Chancellor for Research and Innovation at the University of Sheffield] picked up on this in his suggestion for a more relevant application of the Precautionary Principle to emerging technologies:

  1. what are the benefits that the new technology provides – what are the risks and uncertainties associated with not realising these benefits?
  2. what are the risks and uncertainties attached to any current ways we have of realising these benefits using existing technologies?
  3. what are the risks and uncertainties of the new technology?

This seems a useful place to start from when faced with the reality of having to make the best possible decisions in the face of uncertainty, and where inaction isn’t an option.

But to make decisions – even when there are gaping holes in the data – you need something to go on.

The new Swiss matrix helps to further flesh out the precautionary principle (from the July 29,2011 news item on Nanowerk),

The precautionary matrix provides a structured method to assess the “nanospecific precautionary need” of workers, consumers and the environment arising from the production and use of synthetic nanomaterials.

The matrix is a tool to help trade and industry meet their obligations of care and self-monitoring. It helps them to recognise applications which may entail risk and to take precautionary measures to protect human health and the environment. In the case of new developments, the matrix can contribute to the development of safer products. It enables users to conduct an initial analysis on the basis of currently available knowledge and indicates when further investigations are necessary.

The matrix can be found on this page of the Swiss Federal Office of Public Health (scroll to the right of the page for the guidelines, matrix, FAQs, etc.).

One question keeps popping up. The phrase ‘consequences of inaction’ has me asking how do we define inaction? My suspicion is that a research nanoscientist and a representative from a civil society organization may have two very different answers to that question, i.e., ‘we must continue with the research to solve the problem’ as opposed to ‘we must stop the actions that caused the problem in the first place’.

Misunderstanding the data or a failure to research? Georgia Straight article about nanoparticles

It’s good to see articles about nanotechnology. The recent, Tiny nanoparticles could be a big problem, article written by Alex Roslin for the Georgia Straight (July 21, 2011 online or July 21-28, 2011 paper edition) is the first I’ve seen on that topic in that particular newspaper. Unfortunately, there are  some curious bits of information included in the article, which render it, in my opinion, difficult to trust.

I do agree with Roslin that nanoparticles/nanomaterials could constitute a danger and there are a number of studies which indicate that, at the least, extreme caution in a number of cases should be taken if we choose to proceed with developing nanotechnology-enabled products.

One of my difficulties with the article is the information that has been left out. (Perhaps Roslin didn’t have time to properly research?) At the time (2009) I did read with much concern the reports Roslin mentions about the Chinese workers who were injured and/or died after working with nanomaterials. As Roslin points out,

Nanotech already appears to be affecting people’s health. In 2009, two Chinese factory workers died and another five were seriously injured in a plant that made paint containing nanoparticles.

The seven young female workers developed lung disease and rashes on their face and arms. Nanoparticles were found deep in the workers’ lungs.

“These cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs,” wrote Chinese medical researchers in a 2009 study on the incident in the European Respiratory Journal.

Left undescribed by Roslin are the working conditions; the affected people were working in an unventilated room. From the European Respiratory Journal article (ERJ September 1, 2009 vol. 34 no. 3 559-567, free access), Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma,

A survey of the patients’ workplace was conducted. It measures ∼70 m2, has one door, no windows and one machine which is used to air spray materials, heat and dry boards. This machine has three atomising spray nozzles and one gas exhauster (a ventilation unit), which broke 5 months before the occurrence of the disease. The paste material used is an ivory white soft coating mixture of polyacrylic ester.

Eight workers (seven female and one male) were divided into two equal groups each working 8–12 h shifts. Using a spoon, the workers took the above coating material (room temperature) to the open-bottom pan of the machine, which automatically air-sprayed the coating material at the pressure of 100–120 Kpa onto polystyrene (PS) boards (organic glass), which can then be used in the printing and decorating industry. The PS board was heated and dried at 75–100°C, and the smoke produced in the process was cleared by the gas exhauster. In total, 6 kg of coating material was typically used each day. The PS board sizes varied from 0.5–1 m2 and ∼5,000 m2 were handled each workday. The workers had several tasks in the process including loading the soft coating material in the machine, as well as clipping, heating and handling the PS board. Each worker participated in all parts of this process.

Accumulated dust particles were found at the intake of the gas exhauster. During the 5 months preceding illness the door of the workspace was kept closed due to cold outdoor temperatures. The workers were all peasants near the factory, and had no knowledge of industrial hygiene and possible toxicity from the materials they worked with. The only personal protective equipment used on an occasional basis was cotton gauze masks. According to the patients, there were often some flocculi produced during air spraying, which caused itching on their faces and arms. It is estimated that the airflow or turnover rates of indoor air would be very slow, or quiescent due to the lack of windows and the closed door. [emphases mine]

Here’s the full text from the researchers’ conclusion,

In conclusion, these cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs. It is impossible to remove nanoparticles that have penetrated the cell and lodged in the cytoplasm and caryoplasm of pulmonary epithelial cells, or that have aggregated around the red blood cell membrane. Effective protective methods appear to be extremely important in terms of protecting exposed workers from illness caused by nanoparticles.

There is no question that serious issues about occupational health and safety with regards to nanomaterials were raised. But, we work with dangerous and hazardous materials all the time; precautions are necessary whether you’re working with hydrochloric acid or engineered nanoparticles. (There are naturally occurring nanoparticles too.)

Dr. Andrew Maynard (at the time he was the Chief Science Advisor for the Project on Emerging Nanotechnologies, today he is the Director of the University of Michigan’s Risk Science Center) on his 2020 Science blog wrote a number of posts dated Aug. 18, 2009 about this tragic industrial incident, including this one where he culled comments from six other researchers noting some of the difficulties the Chinese researchers experienced running a clinical study after the fact.

The material on silver nanoparticles and concerns about their use in consumer products and possible toxic consequences with their eventual appearance in the water supply seem unexceptionable to me. (Note:  I haven’t drilled down into the material and the writer cites studies unknown to me but they parallel information I’ve seen elsewhere).

The material on titanium dioxide as being asbestos-like was new to me, the only nanomaterial I’d previously heard described as being similar to asbestos is the long carbon nanotube. I am surprised Roslin didn’t mention that occupational health and safety research which is also quite disturbing, it’s especially surprising since Roslin does mention carbon nanotubes later in the article.

There is a Canadian expert, Dr. Claude Ostiguy, who consults internationally on the topic of nanotechnology and occupational health and safety. I wonder why he wasn’t consulted. (Note: He testified before Canada’s House of Commons Standing Committee on Health meeting in June 2010 on this topic. You can find more about this in my June 23, 2011 posting, Nanomaterials, toxicity, and Canada’s House of Commons Standing Committee on Health.)

Quoted quite liberally throughout the article is researcher, Dr.Robert Schiestl (professor of pathology and radiation oncology at the University of California at Los Angeles [UCLA]). This particular passage referencing Schiestl is a little disconcerting,

Schiestl said nanoparticles could also be helping to fuel a rise in the rates of some cancers. He wouldn’t make a link with any specific kind of cancer, but data from the U.S. National Cancer Institute show that kidney and renal-pelvis cancer rates rose 24 percent between 2000 and 2007 in the U.S., while the rates for melanoma of the skin went up 29 percent and thyroid cancer rose 54 percent.

Since Schiestl isn’t linking the nanoparticles to any specific cancers, why mention those statistics? Using that kind of logic I could theorize that the increase in the number and use of cell phones (mobiles) may have something to do with these cancers. Perhaps organic food has caused this increase? You see the problem?

As for the number of nanotechnology-enabled products in use, I’m not sure why Roslin chose to cite the Project on Emerging Nanotechnologies’ inventory which is not scrutinized, i. e., anyone can register any product as nanotechnology-enabled. The writer also mentioned a Canadian inventory listing over 1600 products  cited in an ETC Group report, The Big Downturn? Nanogeopolitics,

Has anyone ever seen this inventory? I’ve been chasing it for years and the only time the Canadian government reports on this inventory is in the Organization for Economic Cooperation and Development (OECD) report (cited by the ETC Group [no. 79 in their list of references] and noted in both my Feb. 1, 2011 posting and my April 12, 2010 posting). Here’s the OECD report, if you’d like to see it for yourself. The top three questions I keep asking myself is where is the report/inventory, how did they determine their terms of reference, and why don’t Canadian taxpayers have easy access to it? I’d best return to my main topic.

As for the material Roslin offers about nanosunscreens I was surprised given the tenor of the article to see that the Environmental Working Group (EWG) was listed as an information source since they recommend mineral sunscreens containing nanoscale ingredients such as titanium dioxide and/or zinc oxide as preferable to sunscreens containing hormone disruptors.  From the EWG page on sunscreens and nanomaterials,

Sunscreen makers offer mineral and non-mineral formulations, as well as products that combine both mineral and non-mineral active ingredients. Mineral formulations incorporate zinc oxide or titanium dioxide in nano- and micro-sized particles that can be toxic if they penetrate the skin. Most studies show that these ingredients do not penetrate through skin to the bloodstream, but research continues. These constitute one in five sunscreens on the market in 2010 and offer strong UVA protection that is rare in non-mineral sunscreens.

The most common ingredients in non-mineral sunscreens are oxybenzone, octisalate, octinoxate, and avobenzone found in 65, 58, 57, and 56 percent of all non-mineral sunscreens on the market, respectively. The most common, oxybenzone, can trigger allergic reactions, is a potential hormone disruptor and penetrates the skin in relatively large amounts. Some experts caution that it should not be used on children. Three of every five sunscreens rated by EWG are non-mineral, and one in five sunscreens combines both mineral and non-mineral active ingredients.

EWG reviewed the scientific literature on hazards and efficacy (UVB and UVA protection) for all active ingredients approved in the U.S. Though no ingredient is without hazard or perfectly effective, on balance our ratings tend to favor mineral sunscreens because of their low capacity to penetrate the skin and the superior UVA protection they offer. [emphasis mine]

(I did find some information (very little) about Health Canada and sunscreens which I discuss in June 3, 2011 posting [if you’re impatient, scroll down about 1/2 way].)

There was some mention of Health Canada in Roslin’s article but no mention of last year’s public consultation, although to be fair, it seemed a clandestine operation. (My latest update on the Health Canada public consultation about a definition for nanomaterials is May 27, 2011.)

I find some aspects of the article puzzling as Roslin is an award-winning investigative reporter. From the kitco bio page,

Alex Roslin is a leading Canadian investigative journalist and active trader based in Montreal. He has won a Canadian Association of Journalists award for investigative reporting and is a five-time nominee for investigative and writing prizes from the CAJ and the National Magazine Awards. He has worked on major investigations for Canada’s premier investigative television program, the fifth estate, and the CBC’s Disclosure program. His writing has appeared in Technical Analysis of Stocks & Commodities, The Financial Post, Toronto Star and Montreal Gazette. He regularly writes about investing for The Montreal Gazette.

I notice there’s no mention of writing in either science or health matters so I imagine this is an early stage piece in this aspect of Roslin’s career, which may explain some of the leaps in logic and misleading information. Happily, I did learn a few things from reading the article and while I don’t trust much of the information in it, I will investigate further as time permits.

In general, I found the tenor of the article more alarmist than informational and I’m sorry about that as I would like to see more information being shared and, ultimately, public discussion in Canada about nanotechnology and other emerging technologies.

McGill green chemistry breakthrough in Québec Science’s top ten list; cinnamon green chemistry

McGill University researchers, Chao-Jun Li, Audrey Moores and their colleagues, earned their spot in Québec Science’s top 10 list of 2010 with a nanotech catalyst that makes it possible to reduce the use of toxic heavy metals from chemical processes. From the news release,

Catalysts are substances used to facilitate and drive chemical reactions. Although chemists have long been aware of the ecological and economic effects of traditional chemical catalysts and do attempt to reuse their materials, it is generally difficult to separate the catalyzing chemicals from the finished product. The team’s discovery does away with this chemical process altogether.

Li, a professor in the Department of Chemistry and Canada Research Chair in Organic/Green Chemistry, neatly describes the new catalyst as a way to “use a magnet and pull them out!” The technology is known as nanomagnetics and involves nanoparticles of a simple iron magnet. Nanoparticles are sized between 1 and 100 nanometres (a strand of hair is about 80,000 nanometres wide). The catalyst itself is chemically benign and can be efficiently recycled. In terms of practical applications, their method can already be used to generate the reactions that are required for example in pharmaceutical research, and could in the future be used to achieve reactions necessary for research in other industries and fields. The discovery was published in Highlights in Chemical Science in January 18, 2010, in an article authored by Li, Moores, Tieqiang Zeng, Wen-Wen Chen, Ciprian M. Cirtiu, and Gonghua Song.

Li is known as one of the world’s pioneers in Green Chemistry, an entirely new approach to the science that tries to avoid the use of toxic, petrochemical-based solvents in favour of basic substances. More than 97 per cent of all products we use involves one or more chemical reactions. The future of not only the trillion-dollar chemical industry, but also the overall economy and the health of ecosystems and populations around the world rests on our ability to find sustainable solutions to chemical use. With 25 key researchers, 117 graduate students and more than 15 postdoctoral fellows working at ways to reduce the toxicity of chemical processes, McGill is a recognized global leader in the field. The University’s pioneering work in Green Chemistry dates back to the 1960s, when phrases such as “chemicals from renewable resources” and “non-polluting chemicals” were used.

The magazine, Québec Science, is asking its readers to vote by Feb. 25, 2011 for the top discovery of 2010. You can go here to vote (you will need to be able to read French).

Feb. 17, 2010, I featured this McGill team’s 2010 green chemistry (starting in the 3rd paragraph).

Since we’re on the topic of green chemistry, I now have the opportunity to mention a Nov. 29, 2010 news item on Nanowerk about how cinnamon could be used to replace dangerous chemicals used to create nanoparticles (from the news item),

Gold nanoparticles, tiny pieces of gold so small that they can’t be seen by the naked eye, are used in electronics, healthcare products and as pharmaceuticals to fight cancer. Despite their positive uses, the process to make the nanoparticles requires dangerous and extremely toxic chemicals. While the nanotechnology industry is expected to produce large quantities of nanoparticles in the near future, researchers have been worried about the environmental impact of the global nanotechnological revolution.

Now, a study by a University of Missouri research team, led by MU scientist Kattesh Katti, curators’ professor of radiology and physics in the School of Medicine and the College of Arts and Science, senior research scientist at the University of Missouri Research Reactor and director of the Cancer Nanotechnology Platform, has found a method that could replace nearly all of the toxic chemicals required to make gold nanoparticles. The missing ingredient can be found in nearly every kitchen’s spice cabinet – cinnamon.

… The new process uses no electricity and utilizes no toxic agents. …

During the study, the researchers found that active chemicals in cinnamon are released when the nanoparticles are created. When these chemicals, known as phytochemicals, are combined with the gold nanoparticles, they can be used for cancer treatment. The phytochemicals can enter into cancer cells and assist in the destruction or imaging of cancer cells, Katti  said.

“Our gold nanoparticles are not only ecologically and biologically benign, they also are biologically active against cancer cells,” Katti said.

As the list of applications for nanotechnology grows in areas such as electronics, healthcare products and pharmaceuticals, the ecological implications of nanotechnology also grow. When considering the entire process from development to shipping to storage, creating gold nanoparticles with the current process can be incredibly harmful to the environment, Chanda [Nripen Chanda, a research associate scientist] said.

Counterbalancing some of this ‘feel good’ green chemistry news focused on reducing environmental impacts posed by chemical processes is a report debunking some the nanotechnology community’s ‘green’ claims, released Nov. 17, 2010, by the Friends of the Earth (FoE), Nanotechnology, climate and energy: Over-heated promises and hot air? You can view the report here. There’s also a new report, released Dec. 17, 2010,  from the ETC Group, The Big Downturn? Nanogeopolitics. As you can tell from the title, the report is more of an overview (it’s an update of a 2005 report) but it does provide information about green nanotechnology. I hope to have some time in the next month or so to discuss these reports rather than just refer to them.