Monthly Archives: June 2023

Adding as little as 0.1% of rosmarinic acid reduced amount of sunscreen needed to protect skin and more

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Since metallic nanoparticles are now pretty much accepted as being relatively safe ingredients, I don’t write about sunscreens very often anymore. Of course metallic nanoparticles had to be rebranded as ‘minerals’ after some civil society groups raised a great fuss. (See my February 9, 2012 posting “Unintended consequences: Australians not using sunscreens to avoid nanoparticles?” for a rundown of the situation.)

This April 5, 2023 news item about a different kind of sunscreen ingredient on phys.org caught my eye,

An article published in the journal Cosmetics reports an investigation of the effects of including rosmarinic acid, an active antioxidant, in a sunscreen along with two conventional ultraviolet light filters, ethylhexyl methoxycinnamate (against UVB) and avobenzone (against UVA).

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They don’t seem to have tested this new ingredient in any ‘mineral’ sunscreens but it seems an intriguing possibility. Here’s more about rosmarinic acid and why it may be a good addition to sunscreens from an April 5, 2023 Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation; FAPESP) press release (also on EurekAlert), which originated the news item, Note: Links have been removed)

The research group increased the sunscreen’s photoprotective efficacy by adding rosmarinic acid at 0.1%, a very small proportion compared with those of conventional UV filters. They believe their findings suggest that incorporating natural molecules with antioxidant activities into sunscreens could decrease the proportion of conventional UV filters in the final product, with the advantage of providing other functional properties.

The product’s performance improved without the need to increase active principle levels, reducing both the amount of sunscreen needed to protect the same skin area and the volume of synthetic chemicals discharged into the environment.

In vitro and clinical trials obtained a 41% increase in sun protection factor (SPF). The higher the SPF, the more sunburn protection increases.

Another advantage of including rosmarinic acid was the addition of antioxidant activity to photoprotection so that the product could be used in antiaging cosmetics, for example.

“Our research on photoprotective systems aims primarily to evaluate potential sunscreen enhancement strategies. We’re interested above all in discovering ways to increase sunburn protection while also improving the stability of the product so that it remains safe and effective for longer,” said pharmaceutical scientist and biochemist André Rolim Baby, last author of the article and a professor at the University of São Paulo’s School of Pharmaceutical Sciences (FCF-USP) in Brazil.

“We’re also looking for products or systems with less environmental impact and ways of reducing the concentration of conventional filters by including natural ingredients that enhance the formulation. And we’re very interested in mapping other cosmetic properties of photoprotective molecules, such as anti-free radical action and protection of biomarkers in the outermost skin layers.”

Multifunctional compound

The investigation was part of a project supported by FAPESP to map chemopreventive properties of various UV filters.

In addition to being an antioxidant, rosmarinic acid, a natural polyphenol antioxidant found in rosemary, as well as sage, peppermint and many other herbal plants, has antiviral, anti-inflammatory, immunomodulatory, antibiotic and anticancer properties.

In a review article published in 2022 in the journal Nutrients, the research group highlighted the beneficial effects of rosmarinic acid as a food supplement, such as improvement in skin firmness and wrinkle reduction.

“In another investigation, we found potential benefits of rosmarinic acid for skin surface hydration, reinforcing the need for more research on the substance in the field of cosmetology,” Baby said.

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Here’s a link to and a citation for the research team’s latest paper,

Photoprotective Efficacy of the Association of Rosmarinic Acid 0.1% with Ethylhexyl Methoxycinnamate and Avobenzone by Maíra de Oliveira Bispo, Ana Lucía Morocho-Jácome, Cassiano Carlos Escudeiro, Renata Miliani Martinez, Claudinéia Aparecida Sales de Oliveira Pinto, Catarina Rosado, Maria Valéria Robles Velasco and André Rolim Baby. Cosmetics 2023, 10(1), 11; https://doi.org/10.3390/cosmetics10010011 Published: 5 January 2023 (This article belongs to the Special Issue Feature Papers in Cosmetics in 2022)

This paper is open access.

Gene editing the lungs with nanoparticles

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The nanoparticles in question are lipid nanoparticles designed for delivery to the lungs and they are somewhat similar to the ones in some of the COVID-19 vaccines (mRNA vaccines). From a March 30, 2023 news item on Nanowerk,

Engineers at MIT [Massachusetts Institute of Technology] and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

With further development, these particles could offer an inhalable treatment for cystic fibrosis and other diseases of the lung, the researchers say.

“This is the first demonstration of highly efficient delivery of RNA to the lungs in mice. We are hopeful that it can be used to treat or repair a range of genetic diseases, including cystic fibrosis,” says Daniel Anderson, a professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES).

In a study of mice, Anderson and his colleagues used the particles to deliver mRNA encoding the machinery needed for CRISPR/Cas9 gene editing. That could open the door to designing therapeutic nanoparticles that can snip out and replace disease-causing genes.

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins. Credits: Image: iStock, edited by MIT News

A March 30, 2023 MIT news release, also on EurekAlert, which originated the news item, describes the research in more detail,

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Targeting the lungs

Messenger RNA holds great potential as a therapeutic for treating a variety of diseases caused by faulty genes. One obstacle to its deployment thus far has been difficulty in delivering it to the right part of the body, without off-target effects. Injected nanoparticles often accumulate in the liver, so several clinical trials evaluating potential mRNA treatments for diseases of the liver are now underway. RNA-based Covid-19 vaccines, which are injected directly into muscle tissue, have also proven effective. In many of those cases, mRNA is encapsulated in a lipid nanoparticle — a fatty sphere that protects mRNA from being broken down prematurely and helps it enter target cells. 

Several years ago, Anderson’s lab set out to design particles that would be better able to transfect the epithelial cells that make up most of the lining of the lungs. In 2019, his lab created nanoparticles that could deliver mRNA encoding a bioluminescent protein to lung cells. Those particles were made from polymers instead of lipids, which made them easier to aerosolize for inhalation into the lungs. However, more work is needed on those particles to increase their potency and maximize their usefulness. 

In their new study, the researchers set out to develop lipid nanoparticles that could target the lungs. The particles are made up of molecules that contain two parts: a positively charged headgroup and a long lipid tail. The positive charge of the headgroup helps the particles to interact with negatively charged mRNA, and it also help mRNA to escape from the cellular structures that engulf the particles once they enter cells. 

The lipid tail structure, meanwhile, helps the particles to pass through the cell membrane. The researchers came up with 10 different chemical structures for the lipid tails, along with 72 different headgroups. By screening different combinations of these structures in mice, the researchers were able to identify those that were most likely to reach the lungs. 

Efficient delivery

In further tests in mice, the researchers showed that they could use the particles to deliver mRNA encoding CRISPR/Cas9 components designed to cut out a stop signal that was genetically encoded into the animals’ lung cells. When that stop signal is removed, a gene for a fluorescent protein turns on. Measuring this fluorescent signal allows the researchers to determine what percentage of the cells successfully expressed the mRNA.

After one dose of mRNA, about 40 percent of lung epithelial cells were transfected, the researchers found. Two doses brought the level to more than 50 percent, and three doses up to 60 percent. The most important targets for treating lung disease are two types of epithelial cells called club cells and ciliated cells, and each of these was transfected at about 15 percent. 

“This means that the cells we were able to edit are really the cells of interest for lung disease,” Li says. “This lipid can enable us to deliver mRNA to the lung much more efficiently than any other delivery system that has been reported so far.”

The new particles also break down quickly, allowing them to be cleared from the lung within a few days and reducing the risk of inflammation. The particles could also be delivered multiple times to the same patient if repeat doses are needed. This gives them an advantage over another approach to delivering mRNA, which uses a modified version of harmless adenoviruses. Those viruses are very effective at delivering RNA but can’t be given repeatedly because they induce an immune response in the host.

To deliver the particles in this study, the researchers used a method called intratracheal instillation, which is often used as a way to model delivery of medication to the lungs. They are now working on making their nanoparticles more stable, so they could be aerosolized and inhaled using a nebulizer. 

The researchers also plan to test the particles to deliver mRNA that could correct the genetic mutation found in the gene that causes cystic fibrosis, in a mouse model of the disease. They also hope to develop treatments for other lung diseases, such as idiopathic pulmonary fibrosis, as well as mRNA vaccines that could be delivered directly to the lungs.

Here’s a link to and a citation from the paper,

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing by Bowen Li, Rajith Singh Manan, Shun-Qing Liang, Akiva Gordon, Allen Jiang, Andrew Varley, Guangping Gao, Robert Langer, Wen Xue & Daniel Anderson. Nature Biotechnology (2023) DOI: https://doi.org/10.1038/s41587-023-01679-x Published 30 March 2023

This paper is behind a paywall.

Combining silicon with metal oxide memristors to create powerful, low-energy intensive chips enabling AI in portable devices

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In this one week, I’m publishing my first stories (see also June 13, 2023 posting “ChatGPT and a neuromorphic [brainlike] synapse“) where artificial intelligence (AI) software is combined with a memristor (hardware component) for brainlike (neuromorphic) computing.

Here’s more about some of the latest research from a March 30, 2023 news item on ScienceDaily,

Everyone is talking about the newest AI and the power of neural networks, forgetting that software is limited by the hardware on which it runs. But it is hardware, says USC [University of Southern California] Professor of Electrical and Computer Engineering Joshua Yang, that has become “the bottleneck.” Now, Yang’s new research with collaborators might change that. They believe that they have developed a new type of chip with the best memory of any chip thus far for edge AI (AI in portable devices).

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A March 29, 2023 University of Southern California (USC) news release (also on EurekAlert), which originated the news item, contextualizes the research and delves further into the topic of neuromorphic hardware,

For approximately the past 30 years, while the size of the neural networks needed for AI and data science applications doubled every 3.5 months, the hardware capability needed to process them doubled only every 3.5 years. According to Yang, hardware presents a more and more severe problem for which few have patience. 

Governments, industry, and academia are trying to address this hardware challenge worldwide. Some continue to work on hardware solutions with silicon chips, while others are experimenting with new types of materials and devices.  Yang’s work falls into the middle—focusing on exploiting and combining the advantages of the new materials and traditional silicon technology that could support heavy AI and data science computation. 

Their new paper in Nature focuses on the understanding of fundamental physics that leads to a drastic increase in memory capacity needed for AI hardware. The team led by Yang, with researchers from USC (including Han Wang’s group), MIT [Massachusetts Institute of Technology], and the University of Massachusetts, developed a protocol for devices to reduce “noise” and demonstrated the practicality of using this protocol in integrated chips. This demonstration was made at TetraMem, a startup company co-founded by Yang and his co-authors  (Miao Hu, Qiangfei Xia, and Glenn Ge), to commercialize AI acceleration technology. According to Yang, this new memory chip has the highest information density per device (11 bits) among all types of known memory technologies thus far. Such small but powerful devices could play a critical role in bringing incredible power to the devices in our pockets. The chips are not just for memory but also for the processor. And millions of them in a small chip, working in parallel to rapidly run your AI tasks, could only require a small battery to power it. 

The chips that Yang and his colleagues are creating combine silicon with metal oxide memristors in order to create powerful but low-energy intensive chips. The technique focuses on using the positions of atoms to represent information rather than the number of electrons (which is the current technique involved in computations on chips). The positions of the atoms offer a compact and stable way to store more information in an analog, instead of digital fashion. Moreover, the information can be processed where it is stored instead of being sent to one of the few dedicated ‘processors,’ eliminating the so-called ‘von Neumann bottleneck’ existing in current computing systems.  In this way, says Yang, computing for AI is “more energy efficient with a higher throughput.”

How it works: 

Yang explains that electrons which are manipulated in traditional chips, are “light.” And this lightness, makes them prone to moving around and being more volatile.  Instead of storing memory through electrons, Yang and collaborators are storing memory in full atoms. Here is why this memory matters. Normally, says Yang, when one turns off a computer, the information memory is gone—but if you need that memory to run a new computation and your computer needs the information all over again, you have lost both time and energy.  This new method, focusing on activating atoms rather than electrons, does not require battery power to maintain stored information. Similar scenarios happen in AI computations, where a stable memory capable of high information density is crucial. Yang imagines this new tech that may enable powerful AI capability in edge devices, such as Google Glasses, which he says previously suffered from a frequent recharging issue.

Further, by converting chips to rely on atoms as opposed to electrons, chips become smaller.  Yang adds that with this new method, there is more computing capacity at a smaller scale. And this method, he says, could offer “many more levels of memory to help increase information density.” 

To put it in context, right now, ChatGPT is running on a cloud. The new innovation, followed by some further development, could put the power of a mini version of ChatGPT in everyone’s personal device. It could make such high-powered tech more affordable and accessible for all sorts of applications. 

Here’s a link to and a citation for the paper,

Thousands of conductance levels in memristors integrated on CMOS by Mingyi Rao, Hao Tang, Jiangbin Wu, Wenhao Song, Max Zhang, Wenbo Yin, Ye Zhuo, Fatemeh Kiani, Benjamin Chen, Xiangqi Jiang, Hefei Liu, Hung-Yu Chen, Rivu Midya, Fan Ye, Hao Jiang, Zhongrui Wang, Mingche Wu, Miao Hu, Han Wang, Qiangfei Xia, Ning Ge, Ju Li & J. Joshua Yang. Nature volume 615, pages 823–829 (2023) DOI: https://doi.org/10.1038/s41586-023-05759-5 Issue Date: 30 March 2023 Published: 29 March 2023

This paper is behind a paywall.

The sound of dirt

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So you don’t get your hopes up, this acoustic story doesn’t offer any accompanying audio/acoustic files, i.e., I couldn’t find the sound of dirt.

In any event, there’s still an interesting story in an April 10, 2023 news item on phys.org,

U.K. and Australian ecologists have used audio technology to record different types of sounds in the soils of a degraded and restored forest to indicate the health of ecosystems.

Non-invasive acoustic monitoring has great potential for scientists to gather long-term information on species and their abundance, says Flinders University [Australia] researcher Dr. Jake Robinson, who conducted the study while at the University of Sheffield in England.

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Photo: Pixabay

An April 8, 2023 Flinders University press release, which originated the news item, delves into the researcher’s work, Note: Links have been removed,

“Eco-acoustics can measure the health lf landscapes affected by farming, mining and deforestation but can also monitor their recovery following revegetation,” he says.  

“From earthworms and plant roots to shifting soils and other underground activity, these subtle sounds were stronger and more diverse in healthy soils – once background noise was blocked out.”   

The subterranean study used special microphones to collect almost 200 sound samples, each about three minutes long, from soil samples collected in restored and cleared forests in South Yorkshire, England. 

“Like underwater and above-ground acoustic monitoring, below-ground biodiversity monitoring using eco-acoustics has great potential,” says Flinders University co-author, Associate Professor Martin Breed. 

Since joining Flinders University, Dr Robinson has released his first book, entitled Invisible Friends (DOI: 10.53061/NZYJ2969) [emphasis mine], which covers his core research into ‘how microbes in the environment shape our lives and the world around us’. 

Now a researcher in restoration genomics at the College of Science and Engineering at Flinders University, the new book examines the powerful role invisible microbes play in ecology, immunology, psychology, forensics and even architecture.  

“Instead of considering microbes the bane of our life, as we have done during the global pandemic, we should appreciate the many benefits they bring in keeping plants animals, and ourselves, alive.”  

In another new article, Dr Robinson and colleagues call for a return to ‘nature play’ for children [emphasis mine] to expose their developing immune systems to a diverse array of microbes at a young age for better long-term health outcomes. 

“Early childhood settings should optimise both outdoor and indoor environments for enhanced exposure to diverse microbiomes for social, cognitive and physiological health,” the researchers say.  

“It’s important to remember that healthy soils feed the air with these diverse microbes,” Dr Robinson adds.  

It seems Robinson has gone on a publicity blitz, academic style, for his book. There’s a May 22, 2023 essay by Robinson, Carlos Abrahams (Senior Lecturer in Environmental Biology – Director of Bioacoustics, Nottingham Trent University); and Martin Breed (Associate Professor in Biology, Flinders University) on the Conversation, Note: A link has been removed,

Nurturing a forest ecosystem back to life after it’s been logged is not always easy.

It can take a lot of hard work and careful monitoring to ensure biodiversity thrives again. But monitoring biodiversity can be costly, intrusive and resource-intensive. That’s where ecological acoustic survey methods, or “ecoacoustics”, come into play.

Indeed, the planet sings. Think of birds calling, bats echolocating, tree leaves fluttering in the breeze, frogs croaking and bush crickets stridulating. We live in a euphonious theatre of life.

Even the creatures in the soil beneath our feet emit unique vibrations as they navigate through the earth to commute, hunt, feed and mate.

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Robinson has published three papers within five months of each other, in addition to the book, which seems like heavy output to me.

First, here’s a link to and a citation for the education paper,

Optimising Early Childhood Educational Settings for Health Using Nature-Based Solutions: The Microbiome Aspect by Jake M. Robinson and Alexia Barrable. Educ. Sci. 2023, 13 (2), 211 DOI: https://doi.org/10.3390/educsci13020211
Published: 16 February 2023

This is an open access paper.

For these two links and citations, the articles seem to be very closely linked.,

The sound of restored soil: Measuring soil biodiversity in a forest restoration chronosequence with ecoacoustics by Jake M. Robinson, Martin F. Breed, Carlos Abrahams. doi: https://doi.org/10.1101/2023.01.23.525240 Posted January 23, 2023

The sound of restored soil: using ecoacoustics to measure soil biodiversity in a temperate forest restoration context by Jake M. Robinson, Martin F. Breed, Carlos Abrahams. Restoration Ecology, Online Version of Record before inclusion in an issue e13934 DOI: https://doi.org/10.1111/rec.13934 First published: 22 May 2023

Both links lead to open access papers.

Finally, there’s the book,

Invisible Friends; How Microbes Shape Our Lives and the World Around Us by Jake Robinson. Pelagic Publishing, 2022. ISBN 9781784274337 DOI: 10.53061/NZYJ2969

This you have to pay for.

For those would would like to hear something from nature, I have a May 27, 2022 posting, The sound of the mushroom. Enjoy!

Biohybrid device (a new type of neural implant) could restore limb function

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A March 23, 2023 news item on ScienceDaily announces a neural implant that addresses failures due to scarring issues,

Researchers have developed a new type of neural implant that could restore limb function to amputees and others who have lost the use of their arms or legs.

In a study carried out in rats, researchers from the University of Cambridge used the device to improve the connection between the brain and paralysed limbs. The device combines flexible electronics and human stem cells — the body’s ‘reprogrammable’ master cells — to better integrate with the nerve and drive limb function.

Previous attempts at using neural implants to restore limb function have mostly failed, as scar tissue tends to form around the electrodes over time, impeding the connection between the device and the nerve. By sandwiching a layer of muscle cells reprogrammed from stem cells between the electrodes and the living tissue, the researchers found that the device integrated with the host’s body and the formation of scar tissue was prevented. The cells survived on the electrode for the duration of the 28-day experiment, the first time this has been monitored over such a long period.

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A March 22, 2023 University of Cambridge press release (also on EurekAlert but published March 23, 2023) by Sarah Collins, delves further into the topic,

The researchers say that by combining two advanced therapies for nerve regeneration – cell therapy and bioelectronics – into a single device, they can overcome the shortcomings of both approaches, improving functionality and sensitivity.

While extensive research and testing will be needed before it can be used in humans, the device is a promising development for amputees or those who have lost function of a limb or limbs. The results are reported in the journal Science Advances.

A huge challenge when attempting to reverse injuries that result in the loss of a limb or the loss of function of a limb is the inability of neurons to regenerate and rebuild disrupted neural circuits.

“If someone has an arm or a leg amputated, for example, all the signals in the nervous system are still there, even though the physical limb is gone,” said Dr Damiano Barone from Cambridge’s Department of Clinical Neurosciences, who co-led the research. “The challenge with integrating artificial limbs, or restoring function to arms or legs, is extracting the information from the nerve and getting it to the limb so that function is restored.”

One way of addressing this problem is implanting a nerve in the large muscles of the shoulder and attaching electrodes to it. The problem with this approach is scar tissue forms around the electrode, plus it is only possible to extract surface-level information from the electrode.

To get better resolution, any implant for restoring function would need to extract much more information from the electrodes. And to improve sensitivity, the researchers wanted to design something that could work on the scale of a single nerve fibre, or axon.

“An axon itself has a tiny voltage,” said Barone. “But once it connects with a muscle cell, which has a much higher voltage, the signal from the muscle cell is easier to extract. That’s where you can increase the sensitivity of the implant.”

The researchers designed a biocompatible flexible electronic device that is thin enough to be attached to the end of a nerve. A layer of stem cells, reprogrammed into muscle cells, was then placed on the electrode. This is the first time that this type of stem cell, called an induced pluripotent stem cell, has been used in a living organism in this way.

“These cells give us an enormous degree of control,” said Barone. “We can tell them how to behave and check on them throughout the experiment. By putting cells in between the electronics and the living body, the body doesn’t see the electrodes, it just sees the cells, so scar tissue isn’t generated.”

The Cambridge biohybrid device was implanted into the paralysed forearm of the rats. The stem cells, which had been transformed into muscle cells prior to implantation, integrated with the nerves in the rat’s forearm. While the rats did not have movement restored to their forearms, the device was able to pick up the signals from the brain that control movement. If connected to the rest of the nerve or a prosthetic limb, the device could help restore movement.

The cell layer also improved the function of the device, by improving resolution and allowing long-term monitoring inside a living organism. The cells survived through the 28-day experiment: the first time that cells have been shown to survive an extended experiment of this kind.

The researchers say that their approach has multiple advantages over other attempts to restore function in amputees. In addition to its easier integration and long-term stability, the device is small enough that its implantation would only require keyhole surgery. Other neural interfacing technologies for the restoration of function in amputees require complex patient-specific interpretations of cortical activity to be associated with muscle movements, while the Cambridge-developed device is a highly scalable solution since it uses ‘off the shelf’ cells.

In addition to its potential for the restoration of function in people who have lost the use of a limb or limbs, the researchers say their device could also be used to control prosthetic limbs by interacting with specific axons responsible for motor control.

“This interface could revolutionise the way we interact with technology,” said co-first author Amy Rochford, from the Department of Engineering. “By combining living human cells with bioelectronic materials, we’ve created a system that can communicate with the brain in a more natural and intuitive way, opening up new possibilities for prosthetics, brain-machine interfaces, and even enhancing cognitive abilities.”

“This technology represents an exciting new approach to neural implants, which we hope will unlock new treatments for patients in need,” said co-first author Dr Alejandro Carnicer-Lombarte, also from the Department of Engineering.

“This was a high-risk endeavour, and I’m so pleased that it worked,” said Professor George Malliaras from Cambridge’s Department of Engineering, who co-led the research. “It’s one of those things that you don’t know whether it will take two years or ten before it works, and it ended up happening very efficiently.”

The researchers are now working to further optimise the devices and improve their scalability. The team have filed a patent application on the technology with the support of Cambridge Enterprise, the University’s technology transfer arm.

The technology relies on opti-oxTM enabled muscle cells. opti-ox is a precision cellular reprogramming technology that enables faithful execution of genetic programmes in cells allowing them to be manufactured consistently at scale. The opti-ox enabled muscle iPSC cell lines used in the experiment were supplied by the Kotter lab [Mark Kotter] from the University of Cambridge. The opti-ox reprogramming technology is owned by synthetic biology company bit.bio.

The research was supported in part by the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI), Wellcome, and the European Union’s Horizon 2020 Research and Innovation Programme.

Caption: In a study carried out in rats, researchers from the University of Cambridge used a biohybrid device to improve the connection between the brain and paralysed limbs. The device combines flexible electronics and human stem cells – the body’s ‘reprogrammable’ master cells – to better integrate with the nerve and drive limb function. Credit: University of Cambirdge

Here’s a link to and a citation for the paper,

Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics by Amy E. Rochford, Alejandro Carnicer-Lombarte, Malak Kawan, Amy Jin, Sam Hilton, Vincenzo F. Curto, Alexandra L. Rutz, Thomas Moreau, Mark R. N. Kotter, George G. Malliaras, and Damiano G. Barone. Science Advances 22 Mar 2023 Vol 9, Issue 12 DOI: 10.1126/sciadv.add8162

This paper is open access.

The synthetic biology company mentioned in the press release, bit.bio is here

Mind-controlled robots based on graphene: an Australian research story

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As they keep saying these days, ‘it’s not science fiction anymore’.

It’s so fascinating I almost forgot what it’s like to make a video where it can take hours to get a few minutes (the video is a little over 3 mins.) and all the failures are edited out. Plus, I haven’t found any information about training both the human users and the robotic dogs/quadrupeds. Does it take minutes? hours? days? more? Can you work with any old robotic dog /quadruped or does it have to be the one you’ve ‘gotten to know’? Etc. Bottom line: I don’t know if I can take what I see in the video at face value.

A March 20, 2023 news item on Nanowerk announces the work from Australia,

The advanced brain-computer interface [BCI] was developed by Distinguished Professor Chin-Teng Lin and Professor Francesca Iacopi, from the UTS [University of Technology Sydney; Australia] Faculty of Engineering and IT, in collaboration with the Australian Army and Defence Innovation Hub.

As well as defence applications, the technology has significant potential in fields such as advanced manufacturing, aerospace and healthcare – for example allowing people with a disability to control a wheelchair or operate prosthetics.

“The hands-free, voice-free technology works outside laboratory settings, anytime, anywhere. It makes interfaces such as consoles, keyboards, touchscreens and hand-gesture recognition redundant,” said Professor Iacopi.

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A March 20, 2023 University of Technology Sydney (UTS) press release, also on EurekAlert but published March 19, 2023, which originated the news item, describes the interface in more detail,

“By using cutting edge graphene material, combined with silicon, we were able to overcome issues of corrosion, durability and skin contact resistance, to develop the wearable dry sensors,” she said.

A new study outlining the technology has just been published in the peer-reviewed journal ACS Applied Nano Materials. It shows that the graphene sensors developed at UTS are very conductive, easy to use and robust.

The hexagon patterned sensors are positioned over the back of the scalp, to detect brainwaves from the visual cortex. The sensors are resilient to harsh conditions so they can be used in extreme operating environments.

The user wears a head-mounted augmented reality lens which displays white flickering squares. By concentrating on a particular square, the brainwaves of the operator are picked up by the biosensor, and a decoder translates the signal into commands.

The technology was recently demonstrated by the Australian Army, where soldiers operated a Ghost Robotics quadruped robot using the brain-machine interface [BMI]. The device allowed hands-free command of the robotic dog with up to 94% accuracy.

“Our technology can issue at least nine commands in two seconds. This means we have nine different kinds of commands and the operator can select one from those nine within that time period,” Professor Lin said.

“We have also explored how to minimise noise from the body and environment to get a clearer signal from an operator’s brain,” he said.

The researchers believe the technology will be of interest to the scientific community, industry and government, and hope to continue making advances in brain-computer interface systems.

Here’s a link to and a citation for the paper,

Noninvasive Sensors for Brain–Machine Interfaces Based on Micropatterned Epitaxial Graphene by Shaikh Nayeem Faisal, Tien-Thong Nguyen Do, Tasauf Torzo, Daniel Leong, Aiswarya Pradeepkumar, Chin-Teng Lin, and Francesca Iacopi. ACS Appl. Nano Mater. 2023, 6, 7, 5440–5447 DOI: https://doi.org/10.1021/acsanm.2c05546 Publication Date: March 16, 2023 Copyright © 2023 The Authors. Published by American Chemical Society

This paper is open access.

Comments

For anyone who’s bothered by this, the terminology is fluid. Sometimes you’ll see brain-computer interface (BCI), sometimes you’ll see human-computer interface, or brain-machine interface (BMI) and, as I’ve now found in the video although I notice the Australians are not hyphenating it, brain-robotic interface (BRI).

You can find Ghost Robotics here, the makers of the robotic ‘dog’.

There seems to be a movement to replace the word ‘soldiers’ with warfighters and, according to this video, military practitioners. I wonder how medical doctors and other practitioners feel about the use of ‘practitioners’ in a military context.

ChatGPT and a neuromorphic (brainlike) synapse

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I was teaching an introductory course about nanotechnology back in 2014 and, at the end of a session, stated (more or less) that the full potential for artificial intelligence (software) wasn’t going to be perceived until the hardware (memistors) was part of the package. (It’s interesting to revisit that in light of the recent uproar around AI (covered in my May 25, 2023 posting, which offered a survey of the situation.)

One of the major problems with artificial intelligence is its memory. The other is energy consumption. Both problems could be addressed by the integration of memristors into the hardware, giving rise to neuromorphic (brainlike) computing. (For those who don’t know, the human brain in addition to its capacity for memory is remarkably energy efficient.)

This is the first time I’ve seen research into memristors where software has been included. Disclaimer: There may be a lot more research of this type; I just haven’t seen it before. A March 24, 2023 news item on ScienceDaily announces research from Korea,

ChatGPT’s impact extends beyond the education sector and is causing significant changes in other areas. The AI language model is recognized for its ability to perform various tasks, including paper writing, translation, coding, and more, all through question-and-answer-based interactions. The AI system relies on deep learning, which requires extensive training to minimize errors, resulting in frequent data transfers between memory and processors. However, traditional digital computer systems’ von Neumann architecture separates the storage and computation of information, resulting in increased power consumption and significant delays in AI computations. Researchers have developed semiconductor technologies suitable for AI applications to address this challenge.

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A March 24, 2023 Pohang University of Science & Technology (POSTECH) press release (also on EurekAlert), which originated the news item, provides more detail,

A research team at POSTECH, led by Professor Yoonyoung Chung (Department of Electrical Engineering, Department of Semiconductor Engineering), Professor Seyoung Kim (Department of Materials Science and Engineering, Department of Semiconductor Engineering), and Ph.D. candidate Seongmin Park (Department of Electrical Engineering), has developed a high-performance AI semiconductor device [emphasis mine] using indium gallium zinc oxide (IGZO), an oxide semiconductor widely used in OLED [organic light-emitting diode] displays. The new device has proven to be excellent in terms of performance and power efficiency.

Efficient AI operations, such as those of ChatGPT, require computations to occur within the memory responsible for storing information. Unfortunately, previous AI semiconductor technologies were limited in meeting all the requirements, such as linear and symmetric programming and uniformity, to improve AI accuracy.

The research team sought IGZO as a key material for AI computations that could be mass-produced and provide uniformity, durability, and computing accuracy. This compound comprises four atoms in a fixed ratio of indium, gallium, zinc, and oxygen and has excellent electron mobility and leakage current properties, which have made it a backplane of the OLED display.

Using this material, the researchers developed a novel synapse device [emphasis mine] composed of two transistors interconnected through a storage node. The precise control of this node’s charging and discharging speed has enabled the AI semiconductor to meet the diverse performance metrics required for high-level performance. Furthermore, applying synaptic devices to a large-scale AI system requires the output current of synaptic devices to be minimized. The researchers confirmed the possibility of utilizing the ultra-thin film insulators inside the transistors to control the current, making them suitable for large-scale AI.

The researchers used the newly developed synaptic device to train and classify handwritten data, achieving a high accuracy of over 98%, [emphasis mine] which verifies its potential application in high-accuracy AI systems in the future.

Professor Chung explained, “The significance of my research team’s achievement is that we overcame the limitations of conventional AI semiconductor technologies that focused solely on material development. To do this, we utilized materials already in mass production. Furthermore, Linear and symmetrical programming characteristics were obtained through a new structure using two transistors as one synaptic device. Thus, our successful development and application of this new AI semiconductor technology show great potential to improve the efficiency and accuracy of AI.”

This study was published last week [March 2023] on the inside back cover of Advanced Electronic Materials [paper edition] and was supported by the Next-Generation Intelligent Semiconductor Technology Development Program through the National Research Foundation, funded by the Ministry of Science and ICT [Information and Communication Technologies] of Korea.

Here’s a link to and a citation for the paper,

Highly Linear and Symmetric Analog Neuromorphic Synapse Based on Metal Oxide Semiconductor Transistors with Self-Assembled Monolayer for High-Precision Neural Network Computatio by Seongmin Park, Suwon Seong, Gilsu Jeon, Wonjae Ji, Kyungmi Noh, Seyoung Kim, Yoonyoung Chun. Volume 9, Issue 3 March 2023 2200554 DOI: https://doi.org/10.1002/aelm.202200554 First published online: 29 December 2022

This paper is open access.

Also, there is another approach to using materials such as indium gallium zinc oxide (IGZO) for a memristor. That would be using biological cells as my June 6, 2023 posting, which features work on biological neural networks (BNNs), suggests in relation to creating robots that can perform brainlike computing.

Music of the chemical elements

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It’s a little late since this work was presented at the American Chemical Society’s (ACS) Spring 2023 meeting but it’s a fascinating approach to the periodic table of elements that features a longstanding interest of mine, data sonification.

A March 26, 2023 news item on phys.org announces the then upcoming presentation abut a musical version of the periodic table of elements,

In chemistry, we have He [helium], Fe [iron] and Ca [calcium]—but what about do, re and mi? Hauntingly beautiful melodies aren’t the first things that come to mind when looking at the periodic table of the elements. However, using a technique called data sonification, a recent college graduate has converted the visible light given off by the elements into audio, creating unique, complex sounds for each one. Today [March 26, 2023], the researcher reports the first step toward an interactive, musical periodic table.

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A March 26, 2023 ACS news release on EurekAlert, which originated the news item, provides more detail (the presentation abstract is included),

The researcher will present his results at the spring meeting of the American Chemical Society (ACS). ACS Spring 2023 is a hybrid meeting being held virtually and in-person March 26–30 [2023], and features more than 10,000 presentations on a wide range of science topics.

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Previously, W. Walker Smith, the project’s sole investigator, took his combined passions of music and chemistry and converted the natural vibrations of molecules into a musical composition. “Then I saw visual representations of the discrete wavelengths of light released by the elements, such as scandium,” says Smith. “They were gorgeous and complex, and I thought, ‘Wow, I really want to turn these into music, too.’”

Elements emit visible light when they are energized. This light is made up of multiple individual wavelengths, or particular colors, with brightness levels that are unique for each element. But on paper, the collections of wavelengths for different elements are hard to tell apart visually, especially for the transition metals, which can have thousands of individual colors, says Smith. Converting the light into sound frequencies could be another way for people to detect the differences between elements.

However, creating sounds for the elements on the periodic table has been done before. For instance, other scientists have assigned the brightest wavelengths to single notes played by the keys on a traditional piano. But this approach reduced the rich variety of wavelengths released by some elements into just a few sounds, explains Smith, who is currently a researcher at Indiana University.

To retain as much of the complexity and nuance of the element spectra as possible, Smith consulted faculty mentors at Indiana University, including David Clemmer, Ph.D., a professor in the chemistry department, and Chi Wang, D.M.A., a professor in the Jacobs School of Music. With their assistance, Smith built a computer code for real-time audio that converted each element’s light data into mixtures of notes. The discrete color wavelengths became individual sine waves whose frequency corresponded to that of the light, and their amplitude matched the brightness of the light.

Early in the research process, Clemmer and Smith discussed the pattern similarities between light and sound vibrations. For instance, within the colors of visible light, violet has almost double the frequency of red, and in music, one doubling of frequency corresponds to an octave. Therefore, visible light can be thought of as an “octave of light.” But this octave of light is at a much higher frequency than the audible range. So, Smith scaled the sine waves’ frequencies down by approximately 10-12, fitting the audio output into a range where human ears are most sensitive to differences in pitch.

Because some elements had hundreds or thousands of frequencies, the code allowed these notes to be generated in real time, forming harmonies and beating patterns as they mixed together. “The result is that the simpler elements, such as hydrogen and helium, sound vaguely like musical chords, but the rest have a more complex collection of sounds,” says Smith. For example, calcium sounds like bells chiming together with a rhythm resulting from how the frequencies interact with each other. Listening to the notes from some other elements reminded Smith of a spooky background noise, similar to music used in cheesy horror movies. He was especially surprised by the element zinc, which despite having a large number of colors, sounded like “an angelic choir singing a major chord with vibrato.”

“Some of the notes sound out of tune, but Smith has kept true to that in this translation of the elements into music,” says Clemmer. These off-key tones — known musically as microtones — come from frequencies that are found between the keys of a traditional piano. Agreeing, Wang says, “The decisions as to what’s vital to preserve when doing data sonification are both challenging and rewarding. And Smith did a great job making such decisions from a musical standpoint.”

The next step is to turn this technology into a new musical instrument with an exhibit at the WonderLab Museum of Science, Health, and Technology in Bloomington, Indiana. “I want to create an interactive, real-time musical periodic table, which allows both children and adults to select an element and see a display of its visible light spectrum and hear it at the same time,” says Smith. He adds that this sound-based approach has potential value as an alternative teaching method in chemistry classrooms, because it’s inclusive to people with visual impairments and different learning styles.

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Smith acknowledges support and funding from Indiana University’s Department of Chemistry, Center for Electronic and Computer Music, and Center for Rural Engagement; an Indiana University Undergraduate Research grant; the 2022 Annual Project Jumpstart Innovation Competition; and the Indiana University Hutton Honors College Grant Program.

A recorded media briefing on this topic will be posted Monday, March 27 [2023], by 10 a.m. Eastern time at www.acs.org/acsspring2023briefings. Reporters can request access to media briefings during the embargo period by contacting newsroom@acs.org. [The ACS 2023 Spring Meeting media briefings are freely available as of June 12, 2023. The “What do the elements sound like? Media Briefing” runs approximately 11 mins.]

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If you keep going past the news release, you’ll find this presentation abstract,

Title
Designing an interactive musical periodic table: sonification of visible element emission spectra

Abstract
What does the element helium sound like? What about hydrogen? While these may seem like absurd questions, the process of data sonification can be used to convert the visible spectra of chemical elements into sounds. When stimulated by electricity or heat, elements release distinct wavelengths of light depending on their electron energy levels—a sort of “chemical footprint” unique to every element. These frequencies of light, which we perceive as different colors, can be scaled into the audio range to yield different sonic frequencies, allowing one to hear the different sounds of chemical elements. This research project involved the construction of an interactive musical periodic table, combining musical and visual representations of elemental spectra from high-resolution spectral datasets.

The interactive periodic table was designed using Max/MSP, a programming language that uses digital signal processing (DSP) algorithms to generate real-time audio and visual outputs. This allows all spectral lines of an element to be played simultaneously (as a “chord”) or for individual lines to be played in succession (as a “melody”). This highly interdisciplinary project has applications spanning data analysis, STEAM (STEM [science, technology, engineering, and mathematics] + Arts) education, and public science outreach. Sonification of scientific data provides alternative methods of analysis that can expand access of such data to blind and visually impaired people. Sonification can even enhance data analysis via traditional data visualization by providing a supplementary layer of auditory information, and sonification-based learning models have been shown to improve student engagement and understanding of scientific concepts like protein folding.

This program is currently being implemented in several middle and high school music and science classes, as well as a public music/science show titled “The Sound of Molecules” at WonderLab Museum of Science. Future work will focus on designing a free and open-source version of the program that does not require specialized DSP software.

A new species of frog named after J. R. R. Tolkien

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Caption: Hyloscirtus tolkieni Credit: Juan Carlos Sánchez-Nivicela / Archive Museo de Zoología, Universidad San Francisco de Quito

Magnificent is the word for this frog described in a February 13, 2023 news item on phys.org,

A magnificent [emphasis mine] new species of stream frog from the Andes of Ecuador was named after J. R. R. Tolkien, creator of Middle-earth and author of famous fantasy works “The Hobbit” and “The Lord of the Rings.” It lives in the pristine streams of the Río Negro-Sopladora National Park, a recently declared protected area that preserves thousands of hectares of almost primary forests in southeastern Ecuador.

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A February 14, 2023 Pensoft Publishers blog entry (issued as a February 13, 2023 news release for EurekAlert), which originated the news item, describes stream frogs and the research required to find new species, Note: A link has been removed,

Stream frogs are a group of amphibians that inhabit the high Andes of Venezuela, Colombia, Ecuado, Peru, and Bolivia. Their life is closely linked to the pure rivers and streams in the mountain areas of the Andes, hence the name “stream frogs”. The adults live in the riparian vegetation, and their tadpoles develop among the rocks of the rapid waters of the rivers.

The researchers, Juan C. Sánchez-Nivicela, José M. Falcón-Reibán, and Diego F. Cisneros-Heredia, named the new frog Hyloscirtus tolkieni in honour of one of their favourite writer. JRR Tolkien, a renowned author, poet, philologist and academic, is the creator of Middle-earth and the father of fantastic works such as “The Hobbit” and “The Lord of the Rings”. The amazing colours of this new frog species reminded them of the magnificent creatures from Tolkien’s fantasy worlds. 

Expeditions carried out since 2020 in the Río Negro-Sopladora National Park in Ecuador have allowed the discovery of a large number of species yet unknown to science. A protected area since 2018, this national park, located in the south of the country, is home to large forested areas that remain unstudied.

“For weeks, we explored different areas of the Río Negro-Sopladora National Park, walking from paramo grasslands at 3,100 meters elevation to forests at 1,000 m. We found a single individual of this new species of frog, which we found impressive due to its colouration and large size.”, indicated Juan Carlos Sánchez Nivicela, associate researcher at the Museum of Zoology of the Universidad San Francisco de Quito USFQ and the National Institute of Biodiversity, and co-author of the study where the frog is described.

The Río Negro Stream Frog is easily differentiated from all its frog releatives by its appearance and unique colouration. It is relatively large (65 mm long), a greyish green back with yellow spots and black specks, and a pale pink and black iris. Its throat, belly and flanks as well as the undersides of its legs are golden yellow with large black spots and dots, and its fingers and toes have black bars and spots and broad skin stripes.

“The new species of frog has amazing colours, and it would seem that it lives in a universe of fantasies, like those created by Tolkien. The truth is that the tropical Andes are magical ecosystems where some of the most wonderful species of flora, funga, and fauna in the world are present. Unfortunately, few areas are well protected from the negative impacts caused by humans. Deforestation, unsustainable agricultural expansion, mining, invasive species, and climate changes are seriously affecting Andean biodiversity”, said Diego F. Cisneros-Heredia, director of the Museum of Zoology of the Universidad San Francisco de Quito USFQ and associate researcher of the National Institute of Biodiversity, and co-author of the study.

The species is still only known from one locality and one individual, so information is insufficient to assess its conservation status and the risk of extinction. However, the authors agree that it is urgent to establish research and monitoring actions to study its life history and ecology, as well as its population size and dynamics. In addition, they suggest exploring new sites where additional populations may exist, and assessing whether their long-term conservation is affected by any threats, such as invasive species, mining, emerging diseases, or climate change.

The description of new species is an important mechanism to support global strategies for the conservation of vulnerable environments, since it reveals the great wealth of biodiversity that is linked to countless natural resources and environmental services. For example, amphibians are important pest controllers and play vital ecological roles in the stability of nature. Unfortunately, 57% of amphibian species in Ecuador are threatened by extinction.

This study was published in the international journal ZooKeys, in a scientific article that can be freely downloaded at the following link: https://doi.org/10.3897/zookeys.1141.90290

Here’s a link to and a citation for the paper,

A new stream treefrog of the genus Hyloscirtus (Amphibia, Hylidae) from the Río Negro-Sopladora National Park, Ecuador by Juan C. Sánchez-Nivicela, José M. Falcón-Reibán, Diego F. Cisneros-Heredia. ZooKeys 1141: 75-92 DOI: https://doi.org/10.3897/zookeys.1141.90290 Published: January 19, 2023?

This paper is open access.

BTW, my March 30, 2023 posting features Frog Finders, a citizen science project concerned with conservancy of frogs taking place in my home province of British Columbia.