Monthly Archives: May 2023

‘Poetic meditation’ could enhance qualitative data analysis

Poetry can provide research inspiration. Courtesy: University of Birmingham

I like the opening line in this January 10, 2023 University of Birmingham press release for how it relates poetry to data analysis (Note: A link has been removed),

‘Poetic meditation’ can enhance qualitative data analysis by offering researchers improved sensory experience and an ability to approach data analysis from unexpected directions, a new study reveals.

(For some reason the first line/lede was rewritten for the January 10, 2023 news item on phys.org and for the copy found on EurekAlert.)

The rest of the press release (Note: A link has been removed),

The authors of the study explain that meditation allows researchers to train their body for data collection – improving their capacity to capture unexpected insights and deal with uncertainty and transformation as they incorporate novel interpretations into their research.

The skills enable researchers to understand novel cultural practices. Poetic meditations may prepare the researchers to see the world with different eyes.

Publishing their findings in Journal of Marketing Management, researchers at the University of Birmingham and Kedge Business School, Bordeaux, France, outline a radical new process to help researchers to enhance their work.

Pilar Rojas-Gaviria, from the University of Birmingham, commented: “Scientific wonder prompts us to ask questions about the purpose of consumption, the way markets are created and extended, and how life and human experience are attached to both.

“Academics have always developed theses to resolve questions and explain events, but mindfulness practice can make our bodies an instrument of research – gathering data from different environmental sources. Poetry offers qualitative researchers a useful tool to refigure their surroundings and shed new light on the data they work with.”

Poetic meditation allows researchers to reveal unexpected or previously unnoticed features of market and consumption environments – rather than simply reproducing existing categories and theories.

By recording and presenting poetic meditations through audio media, the researchers demonstrate poetry’s potential to stimulate new ideas that can influence how academics approach data collection or analysis.

The researchers demonstrate the technique with two poetic meditations focusing on the colours green and red. These audio presentations settle the listener into a relaxed state, before taking the listener on an intellectual journey into poetry and philosophy, and ending with a period of meditation.

Robin Canniford, from Kedge Business School, commented: “We believe this technique can inspire researchers to include sound recordings and data presentations in their publications – creating a different approach to communicating and understandingtheir findings.

“Creating a poetic meditation might be a first step in a researcher’s journey that uncovers new sensations, interpretations, and questions – reaching towards unconventional and impactful responses in our research, even when answers seem to be far in the future.”

Poetry in marketing is already proven to be an effective research method to challenge conventional thinking in areas such as branding. It has helped marketers understand markets and consumers – engaging in conversations that capture how people consume products and services.

Here’s a link to and a citation for the paper (where you’ll find an audio file of this paper and supplementary audio files of poetry),

Poetic meditation: (re)presenting the mystery of the field by Pilar Rojas-Gaviria & Robin Canniford. Journal Marketing Management Volume 38, 2022 – Issue 15-16: Presenting Marketing Differently Pages 1821-1831 DOI: 10.1080/0267257X.2022.2112611 Published online: 22 Nov 2022

This paper is open access and because I quite like it, here’s the,

ABSTRACT

How does one use one’s body in qualitative research? Poetic meditation is a technique that offers to enhance researchers’ sensory capacities and embodied practices in research. By using mindfulness practice as a means to relax and focus on sensations, scholars can prepare to embody data collection so as to encounter multiple environmental features including, but not limited to the visual and textual. So too is poetic meditation intended as a tool to help researchers to encounter mysterious moments and to refigure their surroundings in ways that explicitly reframe sensemaking and representation. This companion essay to recorded poetic meditations encourages researchers to embrace mystery as a pathway to knowledge-making, and to build confidence to creatively step outside of common linguistic and theoretical modes.

Enjoy!

Virtual panel discussion: Canadian Strategies for Responsible Neurotechnology Innovation on May 16, 2023

The Canadian Science Policy Centre (CSPC) sent a May 11, 2023 notice (via email) about an upcoming event but first, congratulations (Bravo!) are in order,

The Science Meets Parliament [SMP] Program 2023 is now complete and was a huge success. 43 Delegates from across Canada met with 62 Parliamentarians from across the political spectrum on the Hill on May 1-2, 2023.

The SMP Program is championed by CSPC and Canada’s Chief Science Advisor, Dr. Mona Nemer [through the Office of the Chief Science Advisor {OCSA}].

This Program would not have been possible without the generous support of our sponsors: The Royal Military College of Canada, The Stem Cell Network, and the University of British Columbia.

There are 443 seats in Canada’s Parliament with 338 in the House of Commons and 105 in the Senate and 2023 is the third time the SMP programme has been offered. (It was previously held in 2018 and 2022 according to the SMP program page.)

The Canadian programme is relatively new compared to Australia where they’ve had a Science Meets Parliament programme since 1999 (according to a March 20, 2017 essay by Ken Baldwin, Director of Energy Change Institute at Australian National University for The Conversation). The Scottish have had a Science and the Parliament programme since 2000 (according to this 2022 event notice on the Royal Society of Chemistry’s website).

By comparison to the other two, the Canadian programme is a toddler. (We tend not to recognize walking for the major achievement it is.) So, bravo to the CSPC and OCSA on getting 62 Parliamentarians to make time in their schedules to meet a scientist.

Responsible neurotechnology innovation?

From the Canadian Strategies for Responsible Neurotechnology Innovation event page on the CSPC website,

Advances in neurotechnology are redefining the possibilities of improving neurologic health and mental wellbeing, but related ethical, legal, and societal concerns such as privacy of brain data, manipulation of personal autonomy and agency, and non-medical and dual uses are increasingly pressing concerns [emphasis mine]. In this regard, neurotechnology presents challenges not only to Canada’s federal and provincial health care systems, but to existing laws and regulations that govern responsible innovation. In December 2019, just before the pandemic, the OECD [Organisation for Economic Cooperation and Development] Council adopted a Recommendation on Responsible Innovation in Neurotechnology. It is now urging that member states develop right-fit implementation strategies.

What should these strategies look like for Canada? We will propose and discuss opportunities that balance and leverage different professional and governance approaches towards the goal of achieving responsible innovation for the current state of the art, science, engineering, and policy, and in anticipation of the rapid and vast capabilities expected for neurotechnology in the future by and for this country.

Link to the full OECD Recommendation on Responsible Innovation in Neurotechnology

Date: May 16 [2023]

Time: 12:00 pm – 1:30 pm EDT

Event Category: Virtual Session [on Zoom]

Registration Page: https://us02web.zoom.us/webinar/register/WN_-g8d1qubRhumPSCQi6WUtA

The panelists are:

Dr. Graeme Moffat
Neurotechnology entrepreneur & Senior Fellow, Munk School of Global Affairs & Public Policy [University of Toronto]

Dr. Graeme Moffat is a co-founder and scientist with System2 Neurotechnology. He previously was Chief Scientist and VP of Regulatory Affairs at Interaxon, Chief Scientist with ScienceScape (later Chan-Zuckerberg Meta), and a research engineer at Neurelec (a division of Oticon Medical). He served as Managing Editor of Frontiers in Neuroscience, the largest open access scholarly journal series in the field of neuroscience. Dr. Moffat is a Senior Fellow at the Munk School of Global Affairs and Public Policy and an advisor to the OECD’s neurotechnology policy initiative.

Professor Jennifer Chandler
Professor of Law at the Centre for Health Law, Policy and Ethics, University of Ottawa

Jennifer Chandler is Professor of Law at the Centre for Health Law, Policy and Ethics, University of Ottawa. She leads the “Neuroethics Law and Society” Research Pillar for the Brain Mind Research Institute and sits on its Scientific Advisory Council. Her research focuses on the ethical, legal and policy issues in brain sciences and the law. She teaches mental health law and neuroethics, tort law, and medico-legal issues. She is a member of the advisory board for CIHR’s Institute for Neurosciences, Mental Health and Addiction (IMNA) and serves on international editorial boards in the field of law, ethics and neuroscience, including Neuroethics, the Springer Book Series Advances in Neuroethics, and the Palgrave-MacMillan Book Series Law, Neuroscience and Human Behavior. She has published widely in legal, bioethical and health sciences journals and is the co-editor of the book Law and Mind: Mental Health Law and Policy in Canada (2016). Dr. Chandler brings a unique perspective to this panel as her research focuses on the ethical, legal and policy issues at the intersection of the brain sciences and the law. She is active in Canadian neuroscience research funding policy, and regularly contributes to Canadian governmental policy on contentious matters of biomedicine.

Ian Burkhart
Neurotech Advocate and Founder of BCI [brain-computer interface] Pioneers Coalition

Ian is a C5 tetraplegic [also known as quadriplegic] from a diving accident in 2010. He participated in a ground-breaking clinical trial using a brain-computer interface to control muscle stimulation. He is the founder of the BCI Pioneers Coalition, which works to establish ethics, guidelines and best practices for future patients, clinicians, and commercial entities engaging with BCI research. Ian serves as Vice President of the North American Spinal Cord Injury Consortium and chairs their project review committee. He has also worked with Unite2Fight Paralysis to advocate for $9 million of SCI research in his home state of Ohio. Ian has been a Reeve peer mentor since 2015 and helps lead two local SCI networking groups. As the president of the Ian Burkhart Foundation, he raises funds for accessible equipment for the independence of others with SCI. Ian is also a full-time consultant working with multiple medical device companies.

Andrew Atkinson
Manager, Emerging Science Policy, Health Canada

Andrew Atkinson is the Manager of the Emerging Sciences Policy Unit under the Strategic Policy Branch of Health Canada. He oversees coordination of science policy issues across the various regulatory and research programs under the mandate of Health Canada. Prior to Health Canada, he was a manager under Environment Canada’s CEPA new chemicals program, where he oversaw chemical and nanomaterial risk assessments, and the development of risk assessment methodologies. In parallel to domestic work, he has been actively engaged in ISO [International Organization for Standardization and OECD nanotechnology efforts.

Andrew is currently a member of the Canadian delegation to the OECD Working Party on Biotechnology, Nanotechnology and Converging Technologies (BNCT). BNCT aims to contribute original policy analysis on emerging science and technologies, such as gene editing and neurotechnology, including messaging to the global community, convening key stakeholders in the field, and making ground-breaking proposals to policy makers.

Professor Judy Illes
Professor, Division of Neurology, Department of Medicine, Faculty of Medicine, UBC [University of British Columbia]

Dr. Illes is Professor of Neurology and Distinguished Scholar in Neuroethics at the University of British Columbia. She is the Director of Neuroethics Canada, and among her many leadership positions in Canada, she is Vice Chair of the Canadian Institutes of Health Research (CIHR) Advisory Board of the Institute on Neuroscience, Mental Health and Addiction (INMHA), and chair of the International Brain Initiative (www.internationalbraininitiative.org; www.canadianbrain.ca), Director at Large of the Canadian Academy of Health Sciences, and a member of the Board of Directors of the Council of Canadian Academies.

Dr. Illes is a world-renown expert whose research, teaching and outreach are devoted to ethical, legal, social and policy challenges at the intersection of the brain sciences and biomedical ethics. She has made ground breaking contributions to neuroethical thinking for neuroscience discovery and clinical translation across the life span, including in entrepreneurship and in the commercialization of health care. Dr. Illes has a unique and comprehensive overview of the field of neurotechnology and the relevant sectors in Canada.

One concern I don’t see mentioned is bankruptcy (in other words, what happens if the company that made your neural implant goes bankrupt?) either in the panel description or in the OECD recommendation. My April 5, 2022 posting “Going blind when your neural implant company flirts with bankruptcy (long read)” explored that topic and while many of the excerpted materials present a US perspective, it’s easy to see how it could also apply in Canada and elsewhere.

For those of us on the West Coast, this session starts at 9 am. Enjoy!

*June 20, 2023: This sentence changed (We tend not to recognize that walking for the major achievement it is.) to We tend not to recognize walking for the major achievement it is.

encou(n)ters and more at the University of British Columbia (Vancouver, Canada) on May 15, 2023

I have one upcoming art/science event being held on the University of British Columbia’s (UBC) Vancouver campus. At the very end of this post, there’s a brief mention of two art/climate events to be held at the Peter Wall Institute on campus.

Ars Scientia draws to a close?

Ars Scientia was initially announced in 2021 as a two year initiative between Stewart Blusson Quantum Matter Institute (Blusson QMI), the Morris & Helen Belkin Art Gallery (the Belkin) and UBC’s Department of Physics and Astronomy (UBC PHAS). In other words, physicists and artists collaborating to do something over a two-year period.

There’ve been a number of Ars Scientia talks (use the search term “Ars Scientia” to find them on this blog) and now there’s going to be second (presumably final) symposium, “encou(n)ters.” From a May 9, 2023 Belkin Gallery notice (received via email),

SYMPOSIUM: ENCOU(N)TERS

Monday, May 15 [2023] from 2-6 pm at UBC Botanical Garden [2]

The Ars Scientia research cluster launched a collaborative residency
program in 2021, bringing together artists and physicists to interrogate
the intersections of art and science. Join us at UBC Botanical Garden
for our second annual research symposium, _encou(n)ters_, to learn more
about residency experiences and engage in interdisciplinary discussions
with our participating artist and physicist investigators. Alongside
presentations from Ars Scientia collaborators, we are honoured to invite
Kavita Philip for a keynote lecture. UBC’s Research Excellence Cluster
program seeded Ars Scientia with the objective of creating programming
that fuses the practices of art and science in the emerging [emphasis mine] field of
interdisciplinary research.

Interdisciplinary research is emerging? From the Interdisciplinarity Wikipedia entry, Note: Links have been removed,

Although “interdisciplinary” and “interdisciplinarity” are frequently viewed as twentieth century terms, the concept has historical antecedents, most notably Greek philosophy.[2] Julie Thompson Klein attests that “the roots of the concepts lie in a number of ideas that resonate through modern discourse—the ideas of a unified science, general knowledge, synthesis and the integration of knowledge”,[3] while Giles Gunn says that Greek historians and dramatists took elements from other realms of knowledge (such as medicine or philosophy) to further understand their own material.[4]

For an example of art and science from ancient times, “De rerum natura” or on the “Nature of Things” is a six book poem devoted to physics according to its Wikipedia entry, Note: Links have been removed,

De rerum natura (Latin: [deː ˈreːrʊn naːˈtuːraː]; On the Nature of Things) is a first-century BC didactic poem by the Roman poet and philosopher Lucretius (c. 99 BC – c. 55 BC) with the goal of explaining Epicurean philosophy to a Roman audience. The poem, written in some 7,400 dactylic hexameters, is divided into six untitled books, and explores Epicurean physics through poetic language and metaphors.[1] Namely, Lucretius explores the principles of atomism [emphases mine]; the nature of the mind and soul; explanations of sensation and thought; the development of the world and its phenomena; and explains a variety of celestial and terrestrial phenomena. The universe described in the poem operates according to these physical principles, guided by fortuna (“chance”),[2] and not the divine intervention of the traditional Roman deities.

In 2011, the historian and literary scholar Stephen Greenblatt wrote a popular history book about the poem, entitled The Swerve: How the World Became Modern. In the work, Greenblatt argues that Poggio Bracciolini’s discovery of De rerum natura reintroduced important ideas that sparked the modern age.[98][99][100] The book was well-received, and later earned the 2012 Pulitzer Prize for General Non-Fiction and the 2011 National Book Award for Nonfiction.[101][102]

More recently than Lucretius, Richard Holmes’ 2008 book “The Age of Wonder; How the Romantic Generation Discovered the Beauty and Terror of Science” explores the relationship 19th century English romantic poets had with science.

Getting back to “encou(n)ters,” here are some details from the Belkin Gallery’s event page,

[second annual research symposium, encou(n)ters]

Monday, May 15 [2023] from 2-6 pm at UBC Botanical Garden

The symposium is free and open to the public, but space is limited; RSVP here.

Symposium Program

Building Momentum, 2-3 pm

Opening remarks by Ars Scientia research leads Shelly Rosenblum, Jeremy Heyl and Andrea Damascelli; Artist talks by jg mair with Alannah Hallas and Timothy Taylor

Experiments in Real Space, 3:15-4:30 pm

Introduction and audience participation experience by James Day; Artist talks by Josephine Lee, Kelly Lycan and Justine Chambers, and Scott Billings

Keynote Address: Kavita Philip, 5-6 pm

Introduction by Susan Sechrist; Keynote address by Kavita Philip

Please join us for a reception following the panels to continue the conversation and enjoy the garden

The keynote speaker, Kavita Philip, joined the University of British Columbia in 2020 according to an October 1, 2020 UBC announcement, Note: Links have been removed,

Dr. Kavita Philip has commenced her appointment as the President’s Excellence Chair in Network Cultures, joining UBC as Professor of English with the UBC Department of English Language and Literatures.

Dr. Philip received her Ph.D. in Science and Technology Studies from Cornell University in 1996. Her research and teaching in Global South histories and sociologies of science, computational technologies, environment, network cultures, media, and politics crosses geographic boundaries and ranges across scholarly disciplines. For 25 years, Dr. Philip has been engaged not only in the intellectual task of forging methods to connect techno-scientific, social scientific, and humanistic inquiry, but also in the institutional task of building these collaborative spaces. She seeks to develop public humanities research that acknowledges the intertwined material and social contexts of cultural production. These networked commitments make her the ideal candidate for this chair.

Dr. Philip most recently taught in the History department at the University of California, Irvine. In addition, she has taught in Literature programs as well as Media and Communication Studies, beginning her career at Georgia Tech’s School of Literature, Communication, and Culture (formerly an English Department). There, she participated in the creation of a Bachelor of Science degree in Science, Technology and Culture. Dr. Philip expanded and bridged legacy English department curricula from the 1980s with approaches from STS, eco-criticism, speculative fiction, and media studies. In addition, she founded and ran the “Science, Technology, and Race” project, which was heralded for its exemplary pedagogy and outreach. At Georgia Tech, she received the E. Roe Stamps award for excellence in teaching.

At UC Irvine, in addition to her role as a Professor in History, Dr. Philip was also an affiliated Faculty in Informatics, and the Director and co-founder (with Du Bois scholar Dr. Nahum Chandler) of the research group in Science, Technology and Race at the University of California, Irvine. During her time at UC Irvine, she also served as the Director of the Critical Theory Institute, Director of the Graduate Feminist Emphasis, and Director of Graduate Studies in History.

Susan Sechrist, the scholar, who is introducing Dr. Philip, has this to say about herself on her eponymous blog, Note: Links have been removed,

I write literary and speculative fiction as well as critical essays at the intersection of fiction, science, and mathematics. My feature, Go Figure, is a column about mathematical metaphor in fiction, for the online literary blog Bloom. My math-curious short story, A Desirable Middle, was published by the eclectic Journal of Humanistic Mathematics.

I live in Vancouver, Canada, on the unceded, ancestral territories of the xʷməθkʷəy̓əm (Musqueam Indian Band), Sḵwx̱wú7mesh (Squamish Nation), and səlilwətaɬ (Tsleil-Waututh Nation). I’m a Creative Writing MFA student at the University of British Columbia (UBC) and a Public Scholar, awarded when I was working on a PhD in Interdisciplinary Studies. Before returning to graduate school, I worked as a technical writer and editor for over 20 years, freelancing for clients as varied as high-tech research organizations, academic institutions, software and hardware companies, and technology start-ups.

At a Society for Technical Communication (STC) conference in Las Vegas, I presented a paper on an idea that would become the core of my scholarly research: what if technical writers used figurative and metaphorical language to explicate difficult, complex, scientific ideas? What if technical documentation was actually… interesting? That question led to a Master of Arts in Liberal Studies at Skidmore College, where my thesis was about the connections between literature and mathematical breakthroughs.

There are two other upcoming research events (art and climate change) that you can check out on this Belkin Gallery page (just scroll down past the symposium).

Answer to why Roman concrete was so durable

Roman concrete lasts for millenia while our ‘modern’ concrete doesn’t and that’s what makes the Roman stuff so fascinating. There’s a very good January 6, 2023 Massachusetts Institute of Technology (MIT) news release (also on EurekAlert) which may provide an answer the mystery of the this material’s longevity,

The ancient Romans were masters of engineering, constructing vast networks of roads, aqueducts, ports, and massive buildings, whose remains have survived for two millennia. Many of these structures were built with concrete: Rome’s famed Pantheon, which has the world’s largest unreinforced concrete dome and was dedicated in A.D. 128, is still intact, and some ancient Roman aqueducts still deliver water to Rome today. Meanwhile, many modern concrete structures have crumbled after a few decades.

Researchers have spent decades trying to figure out the secret of this ultradurable ancient construction material, particularly in structures that endured especially harsh conditions, such as docks, sewers, and seawalls, or those constructed in seismically active locations.

Now, a team of investigators from MIT, Harvard University, and laboratories in Italy and Switzerland, has made progress in this field, discovering ancient concrete-manufacturing strategies that incorporated several key self-healing functionalities. The findings are published in the journal Science Advances, in a paper by MIT professor of civil and environmental engineering Admir Masic, former doctoral student Linda Seymour, and four others.

For many years, researchers have assumed that the key to the ancient concrete’s durability was based on one ingredient: pozzolanic material such as volcanic ash from the area of Pozzuoli, on the Bay of Naples. [emphasis mine] This specific kind of ash was even shipped all across the vast Roman empire to be used in construction, and was described as a key ingredient for concrete in accounts by architects and historians at the time.

Under closer examination, these ancient samples also contain small, distinctive, millimeter-scale bright white mineral features, which have been long recognized as a ubiquitous component of Roman concretes. These white chunks, often referred to as “lime clasts,” originate from lime, another key component of the ancient concrete mix. “Ever since I first began working with ancient Roman concrete, I’ve always been fascinated by these features,” says Masic. “These are not found in modern concrete formulations, so why are they present in these ancient materials?”

Previously disregarded as merely evidence of sloppy mixing practices, or poor-quality raw materials, the new study suggests that these tiny lime clasts gave the concrete a previously unrecognized self-healing capability. [emphasis mine] “The idea that the presence of these lime clasts was simply attributed to low quality control always bothered me,” says Masic. “If the Romans put so much effort into making an outstanding construction material, following all of the detailed recipes that had been optimized over the course of many centuries, why would they put so little effort into ensuring the production of a well-mixed final product? There has to be more to this story.”

Upon further characterization of these lime clasts, using high-resolution multiscale imaging and chemical mapping techniques pioneered in Masic’s research lab, the researchers gained new insights into the potential functionality of these lime clasts.

Historically, it had been assumed that when lime was incorporated into Roman concrete, it was first combined with water to form a highly reactive paste-like material, in a process known as slaking. But this process alone could not account for the presence of the lime clasts. Masic wondered: “Was it possible that the Romans might have actually directly used lime in its more reactive form, known as quicklime?”

Studying samples of this ancient concrete, he and his team determined that the white inclusions were, indeed, made out of various forms of calcium carbonate. And spectroscopic examination provided clues that these had been formed at extreme temperatures, as would be expected from the exothermic reaction produced by using quicklime instead of, or in addition to, the slaked lime in the mixture. Hot mixing, the team has now concluded, was actually the key to the super-durable nature.

“The benefits of hot mixing are twofold,” Masic says. “First, when the overall concrete is heated to high temperatures, it allows chemistries that are not possible if you only used slaked lime, producing high-temperature-associated compounds that would not otherwise form. Second, this increased temperature significantly reduces curing and setting times since all the reactions are accelerated, allowing for much faster construction.”

During the hot mixing process, the lime clasts develop a characteristically brittle nanoparticulate architecture, creating an easily fractured and reactive calcium source, which, as the team proposed, could provide a critical self-healing functionality. As soon as tiny cracks start to form within the concrete, they can preferentially travel through the high-surface-area lime clasts. This material can then react with water, creating a calcium-saturated solution, which can recrystallize as calcium carbonate and quickly fill the crack, or react with pozzolanic materials to further strengthen the composite material. These reactions take place spontaneously and therefore automatically heal the cracks before they spread. Previous support for this hypothesis was found through the examination of other Roman concrete samples that exhibited calcite-filled cracks.

To prove that this was indeed the mechanism responsible for the durability of the Roman concrete, the team produced samples of hot-mixed concrete that incorporated both ancient and modern formulations, deliberately cracked them, and then ran water through the cracks. Sure enough: Within two weeks the cracks had completely healed and the water could no longer flow. An identical chunk of concrete made without quicklime never healed, and the water just kept flowing through the sample. As a result of these successful tests, the team is working to commercialize this modified cement material.

“It’s exciting to think about how these more durable concrete formulations could expand not only the service life of these materials, but also how it could improve the durability of 3D-printed concrete formulations,” says Masic.

Through the extended functional lifespan and the development of lighter-weight concrete forms, he hopes that these efforts could help reduce the environmental impact of cement production, which currently accounts for about 8 percent of global greenhouse gas emissions. Along with other new formulations, such as concrete that can actually absorb carbon dioxide from the air, another current research focus of the Masic lab, these improvements could help to reduce concrete’s global climate impact.

The research team included Janille Maragh at MIT, Paolo Sabatini at DMAT in Italy, Michel Di Tommaso at the Instituto Meccanica dei Materiali, in Switzerland, and James Weaver at the Wyss Institute for Biologically Inspired Engineering at Harvard University. The work was carried out with the assistance of the archeological museum of Priverno, Italy.

I remember the excitement over volcanic ash (it’s mentioned in my June 3, 2016 posting titled: “Making better concrete by looking to nature for inspiration” and my February 17, 2021 posting “Nuclear power plants take a cue from Roman concrete“). As for something being ignored as unimportant or being a result poor practice when it’s not, that’s one of my favourite kinds of science story.

For the really curious, Jennifer Ouellette’s January 6, 2023 article (Ancient Roman concrete could self-heal thanks to “hot mixing” with quicklime) for Ars Technica provides a little more detail.

Here’s a link to and a citation for the latest paper,

Hot mixing: Mechanistic insights into the durability of ancient Roman concrete by Linda M. Seymour, Janille Maragh, Paolo Sabatini, Michel Di Tommaso, James C. Weaver, and Admir Masic. Science Advances 6 Jan 2023 Vol 9, Issue 1 DOI: 10.1126/sciadv.add1602

This paper is open access.

One last note, DMAT is listed as Paolo Sabatini’s home institution. It is a company for which Sabatini is a co-founder and CEO (chief executive officer). DMAT has this on its About page, “Our mission is to develop breakthrough innovations in construction materials at a global scale. DMAT is at the helm of concrete’s innovation.”

Research on how the body will react to nanomedicines is inconsistent

This is a good general introductory video to nano gold but I have two caveats. It’s very ‘hypey’ (as in hyperbolic) and, as of 2023, it’s eight years old. The information still looks pretty good (after all it was produced by Nature magazine) but should you be watching this five years from now, the situation may have changed. (h/t January 5, 2023 news item on Nanowerk)

The video, which includes information about how nano gold can be used to deliver nanomedicines, is embedded in Morteza Mahmoudi’s (Assistant Professor of Radiology, Michigan State University) January 5, 2023 essay on The Conversation about a lack of research on how the body reacts to nanomedicines, Note: Links have been removed,

Nanomedicines took the spotlight during the COVID-19 pandemic. Researchers are using these very small and intricate materials to develop diagnostic tests and treatments. Nanomedicine is already used for various diseases, such as the COVID-19 vaccines and therapies for cardiovascular disease. The “nano” refers to the use of particles that are only a few hundred nanometers in size, which is significantly smaller than the width of a human hair.

Although researchers have developed several methods to improve the reliability of nanotechnologies, the field still faces one major roadblock: a lack of a standardized way to analyze biological identity, or how the body will react to nanomedicines. This is essential information in evaluating how effective and safe new treatments are.

I’m a researcher studying overlooked factors in nanomedicine development. In our recently published research, my colleagues and I found that analyses of biological identity are highly inconsistent across proteomics facilities that specialize in studying proteins.

Nanoparticles (white disks) can be used to deliver treatment to cells (blue). (Image: Brenda Melendez and Rita Serda, National Cancer Institute, National Institutes of Health, CC BY-NC) [downloaded from https://www.nanowerk.com/nanotechnology-news2/newsid=62097.php]

Mahmoudi’s January 5, 2023 essay describes testing a group of laboratories’ analyses of samples he and his team submitted to them (Note: Links have been removed),

We wanted to test how consistently these proteomics facilities analyzed protein corona samples. To do this, my colleagues and I sent biologically identical protein coronas to 17 different labs in the U.S. for analysis.

We had striking results: Less than 2% of the proteins the labs identified were the same.

Our results reveal an extreme lack of consistency in the analyses researchers use to understand how nanomedicines work in the body. This may pose a significant challenge not only to ensuring the accuracy of diagnostics, but also the effectiveness and safety of treatments based on nanomedicines.

… my team and I have identified several critical but often overlooked factors that can influence the performance of a nanomedicine, such as a person’s sex, prior medical conditions and disease type. …

Mahmoudi is pointing out that it’s very early days for nanomedicines and there’s a lot of work still be done.

Here’s a link to and a citation for the paper Mahmoudi and his team had published on this topic,

Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities by Ali Akbar Ashkarran, Hassan Gharibi, Elizabeth Voke, Markita P. Landry, Amir Ata Saei & Morteza Mahmoudi. Nature Communications volume 13, Article number: 6610 (2022) DOI: https://doi.org/10.1038/s41467-022-34438-8 Published 03 November 2022

This paper is open access.

Graphene-based nanoelectronics platform, a replacement for silicon?

A December 31, 2022 news item on phys.org describes research into replacing silicon in the field of electronics, Note: Links have been removed,

A pressing quest in the field of nanoelectronics is the search for a material that could replace silicon. Graphene has seemed promising for decades. But its potential has faltered along the way, due to damaging processing methods and the lack of a new electronics paradigm to embrace it. With silicon nearly maxed out in its ability to accommodate faster computing, the next big nanoelectronics platform is needed now more than ever.

Walter de Heer, Regents’ Professor in the School of Physics at the Georgia Institute of Technology [Georgia Tech], has taken a critical step forward in making the case for a successor to silicon. De Heer and his collaborators have developed a new nanoelectronics platform based on graphene—a single sheet of carbon atoms. The technology is compatible with conventional microelectronics manufacturing, a necessity for any viable alternative to silicon.

In the course of their research, published in Nature Communications, the team may have also discovered a new quasiparticle. Their discovery could lead to manufacturing smaller, faster, more efficient and more sustainable computer chips, and has potential implications for quantum and high-performance computing.

A January 3, 2023 Georgia Institute of Technology news release (also on EurekAlert but published December 21, 2022] by Catherine Barzler, which originated the news item, delves further into the work

“Graphene’s power lies in its flat, two-dimensional structure that is held together by the strongest chemical bonds known,” de Heer said. “It was clear from the beginning that graphene can be miniaturized to a far greater extent than silicon — enabling much smaller devices, while operating at higher speeds and producing much less heat. This means that, in principle, more devices can be packed on a single chip of graphene than with silicon.”

In 2001, de Heer proposed an alternative form of electronics based on epitaxial graphene, or epigraphene — a layer of graphene that was found to spontaneously form on top of silicon carbide crystal, a semiconductor used in high power electronics. At the time, researchers found that electric currents flow without resistance along epigraphene’s edges, and that graphene devices could be seamlessly interconnected without metal wires. This combination allows for a form of electronics that relies on the unique light-like properties of graphene electrons.

“Quantum interference has been observed in carbon nanotubes at low temperatures, and we expect to see similar effects in epigraphene ribbons and networks,” de Heer said. “This important feature of graphene is not possible with silicon.”

Building the Platform

To create the new nanoelectronics platform, the researchers created a modified form of epigraphene on a silicon carbide crystal substrate. In collaboration with researchers at the Tianjin International Center for Nanoparticles and Nanosystems at the University of Tianjin, China, they produced unique silicon carbide chips from electronics-grade silicon carbide crystals. The graphene itself was grown at de Heer’s laboratory at Georgia Tech using patented furnaces.

The researchers used electron beam lithography, a method commonly used in microelectronics, to carve the graphene nanostructures and weld their edges to the silicon carbide chips. This process mechanically stabilizes and seals the graphene’s edges, which would otherwise react with oxygen and other gases that might interfere with the motion of the charges along the edge.

Finally, to measure the electronic properties of their graphene platform, the team used a cryogenic apparatus that allows them to record its properties from a near-zero temperature to room temperature.

Observing the Edge State

The electric charges the team observed in the graphene edge state were similar to photons in an optical fiber that can travel over large distances without scattering. They found that the charges traveled for tens of thousands of nanometers along the edge before scattering. Graphene electrons in previous technologies could only travel about 10 nanometers before bumping into small imperfections and scattering in different directions.

“What’s special about the electric charges in the edges is that they stay on the edge and keep on going at the same speed, even if the edges are not perfectly straight,” said Claire Berger, physics professor at Georgia Tech and director of research at the French National Center for Scientific Research in Grenoble, France.

In metals, electric currents are carried by negatively charged electrons. But contrary to the researchers’ expectations, their measurements suggested that the edge currents were not carried by electrons or by holes (a term for positive quasiparticles indicating the absence of an electron). Rather, the currents were carried by a highly unusual quasiparticle that has no charge and no energy, and yet moves without resistance. The components of the hybrid quasiparticle were observed to travel on opposite sides of the graphene’s edges, despite being a single object.

The unique properties indicate that the quasiparticle might be one that physicists have been hoping to exploit for decades — the elusive Majorana fermion predicted by Italian theoretical physicist Ettore Majorana in 1937.

“Developing electronics using this new quasiparticle in seamlessly interconnected graphene networks is game changing,” de Heer said.

It will likely be another five to 10 years before we have the first graphene-based electronics, according to de Heer. But thanks to the team’s new epitaxial graphene platform, technology is closer than ever to crowning graphene as a successor to silicon.

Here’s a link to and a citation for the paper,

An epitaxial graphene platform for zero-energy edge state nanoelectronics by Vladimir S. Prudkovskiy, Yiran Hu, Kaimin Zhang, Yue Hu, Peixuan Ji, Grant Nunn, Jian Zhao, Chenqian Shi, Antonio Tejeda, David Wander, Alessandro De Cecco, Clemens B. Winkelmann, Yuxuan Jiang, Tianhao Zhao, Katsunori Wakabayashi, Zhigang Jiang, Lei Ma, Claire Berger & Walt A. de Heer. Nature Communications volume 13, Article number: 7814 (2022) DOI: https://doi.org/10.1038/s41467-022-34369-4 Published 19 December 2022

This paper is open access.

Analogue memristor for next-generation brain-mimicking (neuromorphic) computing

This research into an analogue memristor comes from The Korea Institute of Science and Technology (KIST) according to a September 20, 2022 news item on Nanowerk, Note: A link has been removed,

Neuromorphic computing system technology mimicking the human brain has emerged and overcome the limitation of excessive power consumption regarding the existing von Neumann computing method. A high-performance, analog artificial synapse device, capable of expressing various synapse connection strengths, is required to implement a semiconductor device that uses a brain information transmission method. This method uses signals transmitted between neurons when a neuron generates a spike signal.

However, considering conventional resistance-variable memory devices widely used as artificial synapses, as the filament grows with varying resistance, the electric field increases, causing a feedback phenomenon, resulting in rapid filament growth. Therefore, it is challenging to implement considerable plasticity while maintaining analog (gradual) resistance variation concerning the filament type.

The Korea Institute of Science and Technology (KIST), led by Dr. YeonJoo Jeong’s team at the Center for Neuromorphic Engineering, solved the limitations of analog synaptic characteristics, plasticity and information preservation, which are chronic obstacles regarding memristors, neuromorphic semiconductor devices. He announced the development of an artificial synaptic semiconductor device capable of highly reliable neuromorphic computing (Nature Communications, “Cluster-type analogue memristor by engineering redox dynamics for high-performance neuromorphic computing”).

Caption: Concept image of the article Credit: Korea Institute of Science and Technology (KIST)

A September 20, 2022 (Korea) National Research Council of Science & Technology press release on EurekAlert, which originated the news item, delves further into the research,

The KIST research team fine-tuned the redox properties of active electrode ions to solve small synaptic plasticity hindering the performance of existing neuromorphic semiconductor devices. Furthermore, various transition metals were doped and used in the synaptic device, controlling the reduction probability of active electrode ions. It was discovered that the high reduction probability of ions is a critical variable in the development of high-performance artificial synaptic devices.

Therefore, a titanium transition metal, having a high ion reduction probability, was introduced by the research team into an existing artificial synaptic device. This maintains the synapse’s analog characteristics and the device plasticity at the synapse of the biological brain, approximately five times the difference between high and low resistances. Furthermore, they developed a high-performance neuromorphic semiconductor that is approximately 50 times more efficient.

Additionally, due to the high alloy formation reaction concerning the doped titanium transition metal, the information retention increased up to 63 times compared with the existing artificial synaptic device. Furthermore, brain functions, including long-term potentiation and long-term depression, could be more precisely simulated.

The team implemented an artificial neural network learning pattern using the developed artificial synaptic device and attempted artificial intelligence image recognition learning. As a result, the error rate was reduced by more than 60% compared with the existing artificial synaptic device; additionally, the handwriting image pattern (MNIST) recognition accuracy increased by more than 69%. The research team confirmed the feasibility of a high-performance neuromorphic computing system through this improved the artificial synaptic device.

Dr. Jeong of KIST stated, “This study drastically improved the synaptic range of motion and information preservation, which were the greatest technical barriers of existing synaptic mimics.” “In the developed artificial synapse device, the device’s analog operation area to express the synapse’s various connection strengths has been maximized, so the performance of brain simulation-based artificial intelligence computing will be improved.” Additionally, he mentioned, “In the follow-up research, we will manufacture a neuromorphic semiconductor chip based on the developed artificial synapse device to realize a high-performance artificial intelligence system, thereby further enhancing competitiveness in the domestic system and artificial intelligence semiconductor field.”

Here’s a link to and a citation for the paper,

Cluster-type analogue memristor by engineering redox dynamics for high-performance neuromorphic computing by Jaehyun Kang, Taeyoon Kim, Suman Hu, Jaewook Kim, Joon Young Kwak, Jongkil Park, Jong Keuk Park, Inho Kim, Suyoun Lee, Sangbum Kim & YeonJoo Jeong. Nature Communications volume 13, Article number: 4040 (2022) DOI: https://doi.org/10.1038/s41467-022-31804-4 Published: 12 July 2022

This paper is open access.

A fish baying at the moon?

It seems to be GLUBS time again (GLUBS being the Global Library of Underwater Biological Sounds). In fact it’s an altogether acoustical time for the ocean. First, a mystery fish,

That sounds a bit like a trumpet to me. (I last wrote about GLUBS in a March 4, 2022 posting where it was included under the ‘Marine sound libraries’ subhead.)

The latest about GLUBS and aquatic sounds can be found in an April 26, 2023 Rockefeller University news release on EurekAlert, Note 1: I don’t usually include the heads but I quite like this one and even stole part of it for this posting; Note 2: There probably should have been more than one news release; Note 3: For anyone who doesn’t have time to read the entire news release, I have a link immediately following the news release to an informative and brief article about the work,

Do fish bay at the moon? Can their odd songs identify Hawaiian mystery fish? Eavesdropping scientists progress in recording, understanding ocean soundscapes

Using hydrophones to eavesdrop on a reef off the coast of Goa, India, researchers have helped advance a new low-cost way to monitor changes in the world’s murky marine environments.

Reporting their results in the Journal of the Acoustical Society of America (JASA), the scientists recorded the duration and timing of mating and feeding sounds – songs, croaks, trumpets and drums – of 21 of the world’s noise-making ocean species.

With artificial intelligence and other pioneering techniques to discern the calls of marine life, they recorded and identified

Some species within the underwater community work the early shift and ruckus from 3 am to 1.45 pm, others work the late shift and ruckus from 2 pm to 2.45 am, while the plankton predators were “strongly influenced by the moon.”

Also registered: the degree of difference in the abundance of marine life before and after a monsoon.

The paper concludes that hydrophones are a powerful tool and “overall classification performance (89%) is helpful in the real-time monitoring of the fish stocks in the ecosystem.”

The team, including Bishwajit Chakraborty, a leader of the International Quiet Ocean Experiment (IQOE), benefitted from archived recordings of marine species against which they could match what they heard, including:

Also captured was a “buzz” call of unknown origin (https://bit.ly/3GZdRSI), one of the oceans’ countless marine life mysteries.

With a contribution to the International Quiet Ocean Experiment, the research will be discussed at an IQOE meeting in Woods Hole, MA, USA, 26-27 April [2023].

Advancing the Global Library of Underwater Biological Sounds (GLUBS)

That event will be followed April 28-29 by a meeting of partners in the new Global Library of Underwater Biological Sounds (GLUBS), a major legacy of the decade-long IQOE, ending in 2025.

GLUBS, conceived in late 2021 and currently under development, is designed as an open-access online platform to help collate global information and to broaden and standardize scientific and community knowledge of underwater soundscapes and their contributing sources.

It will help build short snippets and snapshots (minutes, hours, days long recordings) of biological, anthropogenic, and geophysical marine sounds into full-scale, tell-tale underwater baseline soundscapes.

Especially notable among many applications of insights from GLUBS information: the ability to detect in hard-to-see underwater environments and habitats how the distribution and behavior of marine life responds to increasing pressure from climate change, fishing, resource development, plastic, anthropogenic noise and other pollutants.

“Passive acoustic monitoring (PAM) is an effective technique for sampling aquatic systems that is particularly useful in deep, dark, turbid, and rapidly changing or remote locations,” says Miles Parsons of the Australian Institute of Marine Science and a leader of GLUBS.

He and colleagues outline two primary targets:

  • Produce and maintain a list of all aquatic species confirmed or anticipated to produce sound underwater;
  • Promote the reporting of sounds from unknown sources

Odd songs of Hawaii’s mystery fish

In this latter pursuit, GLUBS will also help reveal species unknown to science as yet and contribute to their eventual identification.

For example, newly added to the growing global collection of marine sounds are recent recordings from Hawaii, featuring the baffling

now part of an entire YouTube channel (https://bit.ly/3H5Ly54) dedicated to marine life sounds in Hawaii and elsewhere (e.g. this “complete and total mystery from the Florida Keys”: https://bit.ly/41w1Xbc (Annie Innes-Gold, Hawai’i Institute of Marine Biology; processed by Jill Munger, Conservation Metrics, Inc.)

Says Dr. Parsons: “Unidentified sounds can provide valuable information on the richness of the soundscape, the acoustic communities that contribute to it and behavioral interactions among acoustic groups. However, unknown, cryptic and rare sounds are rarely target signals for research and monitoring projects and are, therefore, largely unreported.”

The many uses of underwater sound

Of the roughly 250,000 known marine species, scientists think all fully-aquatic marine mammals (~146, including sub-species) emit sounds, along with at least 100 invertebrates, 1,000 of the world’s ~35,000 known fish species, and likely many thousands more.

GLUBS aims to help delineate essential fish habitat and estimate biomass of a spawning aggregation of a commercially or recreationally important soniferous species.

In one scenario of its many uses, a one-year, calibrated recording can provide a proxy for the timing, location and, under certain circumstances, numbers of ‘calling’ fishes, and how these change throughout a spawning season.

It will also help evaluate the degradation and recovery of a coral reef.

GLUBS researchers envision, for example, collecting recordings from a coral reef that experienced a cyclone or other extreme weather event, followed by widespread bleaching. Throughout its restoration, GLUBS audio data would be matched with and augment a visual census of the fish assemblage at multiple timepoints.

Oil and gas, wind power and other offshore industries will also benefit from GLUBS’ timely information on the possible harms or benefits of their activities.

Other IQOE legacies include

  • Manta (bitbucket.org/CLO-BRP/manta-wiki/wiki/Home), a mechanism created by world experts from academia, industry, and government to help standardize ocean sound recording data, facilitating its comparability, pooling and visualization.
  • OPUS, an Open Portal to Underwater Sound being tested at Alfred Wegener Institute in Bremerhaven, Germany to promote the use of acoustic data collected worldwide, providing easy access to MANTA-processed data, and
  • The first comprehensive database and map of the world’s 200+ known hydrophones recording for ecological purposes 

Marine sounds and COVID-19

The IQOE’s early ambition of humanity’s maritime noise being minimized for a day or week was unexpectedly met in spades when the COVID-19 pandemic began.     

New IQOE research to be considered at the April meeting includes a paper, Impact of the COVID‑19 pandemic on levels of deep‑ocean acoustic noise (https://bit.ly/3KZTaIt) documenting a pandemic-related drop of 1 to 3 dB even in the depths of the abyss. With a 3 dB decrease, sound energy is halved.

Virus control measures led to “sudden and sometimes dramatic reductions in human activity in sectors such as transport, industry, energy, tourism, and construction,” with some of the greatest reductions from March to June 2020 – a drop of up to 13% in container ship traffic and up to 42% in passenger ships.

Other IQOE accomplishments include achieving recognition of ocean sound as an Essential Ocean Variable (EOV) within the Global Ocean Observing System, underlining its helpfulness in monitoring 

  • climate change (the extent and breakup of sea ice; the frequency and intensity of wind, waves and rain)
  • ocean health (biodiversity assessments: monitoring the distribution and abundance of sound-producing species)
  • impacts of human activities on wildlife, and
  • nuclear explosions, foreign/illegal/threatening vessels, human activities in protected areas, and underwater earthquakes that can generate tsunamis

The Partnership for Observation of the Global Ocean (POGO) funded an IQOE Working Group in 2016, which quickly identified the lack of ocean sound as a variable measured by ocean observing systems. This group developed specifications for an Ocean Sound Essential Ocean Variable (EOV) by 2018, which was approved by the Global Ocean Observing System in 2021. IQOE has since developed the Ocean Sound EOV Implementation Plan, reviewed in 2022 and ready for public debut at IQOE’s meeting April 26.

One of IQOE’s originators, Jesse Ausubel of The Rockefeller University’s Programme for the Human Environment, says the programme has drawn attention to the absence of publicly available time series of sound on ecologically important frequencies throughout the global ocean.

“We need to listen more in the blue symphony halls. Animal sounds are behavior, and we need to record and understand the sounds, if we want to know the status of ocean life,” he says.

The program “has provided a platform for the international passive acoustics community to grow stronger and advocate for inclusion of acoustic measurements in national, regional, and global ocean observing systems,” says Prof. Peter Tyack of the University of St. Andrew’s, who, with Steven Simpson, guide the IQOE International Scientific Steering Committee.

“The ocean acoustics and bioacoustics communities had no experience in working together globally, and coverage is certainly not global; there are many gaps. IQOE has begun to help these communities work together globally, and there is still progress to be made in networking and in expanding the deployment of hydrophones, adds Prof. Ausubel.

A description of the project’s history and evaluation to date is available at https://bit.ly/3H7FCbN.

Encouraging greater worldwide use of hydrophones

According to Dr. Parsons, “hydrophones are now being deployed in more locations, more often, by more people, than ever before,” 

To celebrate that, and to mark World Oceans Day, June 8 [2023], GLUBS recently put out a call to hydrophone operators to share marine life recordings made from 7 to 9 June, so far receiving interest from 124 hydrophone operators in 62 organizations from 29 countries and counting. The hydrophones will be retrieved over the following months with the full dataset expected sometime in 2024.

They also plan to make World Oceans Passive Acoustic Monitoring (WOPAM) Day an annual event – a global collaborative study of aquatic soundscapes, salt, brackish or freshwater – the marine world’s answer to the U.S. Audubon Society’s 123-year-old Christmas Bird Count.

Interested researchers with hydrophones [emphasis mine] already planned [sic] to be in the water on June 8 [2023] are invited to contact Miles Parsons (m.parsons@aims.gov.au) or Steve Simpson (s.simpson@bristol.ac.uk).

Becky Ferreira has written April 26, 2023 article for Motherboard that provides more insight into the work being done offshore in Goa and elsewhere,

To better understand the rich reef ecosystems of Goa, a team of researchers at the Indian Council of Scientific and Industrial Research’s National Institute of Oceanography (CSIR-NIO) placed a hydrophone near Grande Island at a depth of about 65 feet. Over the course of several days, the instrument captured hundreds of recordings of the choruses of “soniferous” (sound-making)fish, the high-frequency noises of shrimp, and the rumblings of boats passing near the area.

“Our research, for the longest time, predominantly involved active acoustics systems in understanding habitats (bottom roughness, etc., using multibeam sonar),” said Bishwajit Chakraborty, a marine scientist at CSIR-NIO who co-authored the study, in an email to Motherboard. “By using active sonar systems, we add sound signals to water media which severely affects marine life.” 

Here’s a link to and a citation for the paper mentioned at the beginning of the news release,

Biodiversity assessment using passive acoustic recordings from off-reef location—Unsupervised learning to classify fish vocalization by Vasudev P. Mahale, Kranthikumar Chanda, Bishwajit Chakraborty; Tejas Salkar, G. B. Sreekanth. Journal of the Acoustical Society of America, Volume 153, Issue 3 March 2023 [alternate: J Acoust Soc Am 153, 1534–1553 (2023)] DOI: https://doi.org/10.1121/10.0017248

This paper appears to be open access.

And, one more time,

Interested researchers with hydrophones [emphasis mine] already planned [sic] to be in the water on June 8 [2023] are invited to contact Miles Parsons (m.parsons@aims.gov.au) or Steve Simpson (s.simpson@bristol.ac.uk).

Need to improve oversight on chimeric human-animal research

It seems chimeras are of more interest these days. In all likelihood that has something to do with the fellow who received a transplant of a pig’s heart in January 2022 (he died in March 2022).

For those who aren’t familiar with the term, a chimera is an entity with two different DNA (deoxyribonucleic acid) identities. In short, if you get a DNA sample from the heart, it’s different from a DNA sample obtained from a cheek swab. This contrasts with a hybrid such as a mule (donkey/horse) whose DNA samples show a consisted identity throughout its body.

A December 12, 2022 The Hastings Center news release (also on EurekAlert) announces a special report,

A new report on the ethics of crossing species boundaries by inserting human cells into nonhuman animals – research surrounded by debate – makes recommendations clarifying the ethical issues and calling for improved oversight of this work.

The report, “Creating Chimeric Animals — Seeking Clarity On Ethics and Oversight,” was developed by an interdisciplinary team, with funding from the National Institutes of Health. Principal investigators are Josephine Johnston and Karen Maschke, research scholars at The Hastings Center, and Insoo Hyun, director of the Center for Life Sciences and Public Learning at the Museum of Life Sciences in Boston, formerly of Case Western Reserve University.

Advances in human stem cell science and gene editing enable scientists to insert human cells more extensively and precisely into nonhuman animals, creating “chimeric” animals, embryos, and other organisms that contain a mix of human and nonhuman cells.

Many people hope that this research will yield enormous benefits, including better models of human disease, inexpensive sources of human eggs and embryos for research, and sources of tissues and organs suitable for transplantation into humans. 

But there are ethical concerns about this type of research, which raise questions such as whether the moral status of nonhuman animals is altered by the insertion of human stem cells, whether these studies should be subject to additional prohibitions or oversight, and whether this kind of research should be done at all.

The report found that:

Animal welfare is a primary ethical issue and should be a focus of ethical and policy analysis as well as the governance and oversight of chimeric research.

Chimeric studies raise the possibility of unique or novel harms resulting from the insertion and development of human stem cells in nonhuman animals, particularly when those cells develop in the brain or central nervous system.

Oversight and governance of chimeric research are siloed, and public communication is minimal. Public communication should be improved, communication between the different committees involved in oversight at each institution should be enhanced, and a national mechanism created for those involved in oversight of these studies. 

Scientists, journalists, bioethicists, and others writing about chimeric research should use precise and accessible language that clarifies rather than obscures the ethical issues at stake. The terms “chimera,” which in Greek mythology refers to a fire-breathing monster, and “humanization” are examples of ethically laden, or overly broad language to be avoided.

The Research Team

The Hastings Center

• Josephine Johnston
• Karen J. Maschke
• Carolyn P. Neuhaus
• Margaret M. Matthews
• Isabel Bolo

Case Western Reserve University
• Insoo Hyun (now at Museum of Science, Boston)
• Patricia Marshall
• Kaitlynn P. Craig

The Work Group

• Kara Drolet, Oregon Health & Science University
• Henry T. Greely, Stanford University
• Lori R. Hill, MD Anderson Cancer Center
• Amy Hinterberger, King’s College London
• Elisa A. Hurley, Public Responsibility in Medicine and Research
• Robert Kesterson, University of Alabama at Birmingham
• Jonathan Kimmelman, McGill University
• Nancy M. P. King, Wake Forest University School of Medicine
• Geoffrey Lomax, California Institute for Regenerative Medicine
• Melissa J. Lopes, Harvard University Embryonic Stem Cell Research Oversight Committee
• P. Pearl O’Rourke, Harvard Medical School
• Brendan Parent, NYU Grossman School of Medicine
• Steven Peckman, University of California, Los Angeles
• Monika Piotrowska, State University of New York at Albany
• May Schwarz, The Salk Institute for Biological Studies
• Jeff Sebo, New York University
• Chris Stodgell, University of Rochester
• Robert Streiffer, University of Wisconsin-Madison
• Lorenz Studer, Memorial Sloan Kettering Cancer Center
• Amy Wilkerson, The Rockefeller University

Here’s a link to and a citation for the report,

Creating Chimeric Animals: Seeking Clarity on Ethics and Oversight edited by Karen J. Maschke, Margaret M. Matthews, Kaitlynn P. Craig, Carolyn P. Neuhaus, Insoo Hyun, Josephine Johnston, The Hastings Center Report Volume 52, Issue S2 (Special Report), November‐December 2022 First Published: 09 December 2022

This report is open access.

Support Our Science and the mass student walkout of May 1, 2023

It’s hard to tell how many students and staff participated in yesterday’s (May 1, 2023) Canada-wide walkout. The University of British Columbia (UBC) counted 300 in their walkout (from a May 1, 2023 article by Amir Ali for The Daily Hive). The total number is not available but there is a Nationwide Walkout page on the Support Our Science website with a list of over 30 participating institutions.

I didn’t pay much attention to the concerns from the academic community about the lack of support for Canadian research in my April 24, 2023 posting “The 2023 Canadian federal budget: science & technology of the military and cybersecurity and some closing comments (2 of 2)”; see the”Always a little disappointment” subhead featuring excerpts from a Universities Canada response and Federation for Humanities and Social Sciences briefing on the 2023 federal budget.

Thankfully, others have filled in the gap. Brian Owens wrote an April 28, 2023 article for Nature about the then proposed walkout and the reasons for it, Note: Links have been removed,

“Pay for grad students hasn’t increased in 20 years, while there has been 50% inflation over the same period,” says Sarah Laframboise, a biochemistry PhD student at the University of Ottawa and executive director of Support Our Science, a student-led campaign group that is organizing the walkout.

Scholarships from the federal government provide an annual stipend of Can$17,500 (US$12,800) for master’s degree students, either $23,000 or $35,000 for PhD students, and $45,000 for postdoctoral fellowships. That leaves many researchers in a precarious financial position, says Laframboise. A survey that she and her colleagues conducted of more than 1,000 Canadian graduate students found that almost half of respondents either frequently struggled to make ends meet or were forced to make sacrifices to afford necessities, and 30% had considered leaving their studies because of financial hardship1.

Support our Science has three main demands. First, it wants master’s scholarships to increase in value to $25,900 (a rise of 48%), postdoctoral fellowships to increase to $59,200, and the two levels of PhD scholarship to be equalized at $35,000. Second, it wants a 50% increase in the number of scholarships funded each year, and a doubling in the number of fellowships. Finally, it wants the size of federal research grants to increase by 50%, to allow professors to increase pay for students and postdocs who do not have a federal scholarship. The organization says that these demands are in line with recommendations from the government’s own advisory panel on the research-support system, which published its report in March [2023].

You can find the March 2023 Report of the Advisory Panel on the Federal Research Support System mentioned in Owens’s article here.

That report and more are mentioned in a March 24, 2023 Support Out Science press release issued in response to the 2023 Canadian federal budget,

Support Our Science (SOS) has worked tirelessly over the last year to advocate for increased funding to graduate students and postdoctoral scholars. We are disappointed that the Government of Canada’s Budget 2023 does not include any new investments for the next generation of research and innovation leaders driving Canada’s economy. We recognize the fiscal challenges our nation is currently facing; however, Budget 2023 will have drastic impacts on current graduate and postdoctoral scholars in Canada and will negatively impact the retention and attraction of top talent for years to come.

Of the G7 nations, Canada already makes among the lowest investments in research, development and training. This is documented in the report by the Advisory Panel on the Federal Research Support System, the 2017 Fundamental Science Review, and the 2021 Degrees of Success Report by the Canadian Council of Academies. This budget puts Canada even further behind. Our ability to advance green technologies, cybersecurity, quantum technologies, disease prevention, and many other areas of critical and urgent need are being hampered by the Government of Canada’s lack of investment in the next generation of researchers.

A May 1, 2023 article (with files from Mike Crawley, Joel Ballard and Maurice Katz) on the Canadian Broadcasting Corporation’s (CBC) news website details some of the hardships faced by graduate and postgraduate students, Note: Links have been removed,

A Canada graduate scholarship from one of the three federal research funding agencies is $17,500 per year for a master’s student or $21,000 per year for a doctoral student.

Luis Ramirez, a master’s student at Simon Fraser University (SFU), says the amount he is afforded is barely enough to cover his rent, tuition and food. 

“We’re getting less than $30,000 [per year], even the PhD students.

“We have to pay rent, we have to pay tuition, and we have to pay groceries and clothing and so on. So it’s almost impossible to continue with this. We are on the poverty line right now.” 

UBC graduate student Katrina Bergmann says the low scholarship amounts are “unacceptable.”

“We are the major workforce for Canadian science and innovation,” she said. 

Nancy Forde, a professor at SFU, said federal funding is not meant to make anyone rich but is instead there to ensure researchers can focus on their work without worrying about finances. 

But, she says no one can survive on the amount provided in these scholarship funds, adding that many are using food banks [emphasis mine] to get by. 

“I have students in my own research group who are leaving research because they can’t afford to live,” she said. “They came into the program with savings, and they’ve depleted their savings.”

“Only the privileged can survive.”

In December [2022], Champagne [François-Philippe Champagne, the minister of science, innovation and industry] said he was aware of the call for more funding for graduate researchers and that it would be part of discussions with the finance minister.

“It’s clear that if we want to own the podium, we need to do more to support the researchers, the students and the scientists,” Champagne said.

In a statement, a spokesperson for the federal Science Ministry said it had provided $114 million over five years in the 2019 budget to granting agencies to create 500 master’s scholarships every year, in addition to an $813.6 million increase to student grants in the most recent budget.

The spokesperson did not specifically respond to a question about whether the scholarship amounts would increase. [emphases mins]

It seems students are not the only ones using food banks, from an April 23, 2023 article “UBC staff will no longer be able to access AMS Food Bank due to rising costs” by Nikitha Martins for The Daily Hive,

Kathleen Simpson is a Senior Manager at AMS [Alma Mater Society] and tells Daily Hive the student union’s decision to end support for UBC staff was not one it took lightly.

However, the rising cost of food has driven more people to need support from the AMS food bank and simultaneously made it more expensive to purchase food to operate the food bank.

Last year, the AMS food bank served 7,496 people. By the end of this policy year, the student union expects to help 15,861 people.

“In the last month alone, we saw a 1,000% spike over the previous month, quite unusual, but we are really facing some very high business numbers, and when you combine that with some of the costs of food that have been rising for some of our staple items,” Simpson explained.

AMS has put in a funding request to UBC for $350,000.

“Next year, our cost of groceries alone is projected to cost around $449,000,” Simpson said. “So we’re hoping to hear back… whether or not that full funding will be allocated.”

AMS is asking for nearly double what it received last year from UBC.

I wish them good luck in getting long overdue increases.For the curious, Support Our Science can be found here.