Tag Archives: University of Montreal

Peptide-based hydrogels for faster healing from research team at the University of Ottawa

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While this research team was heavily dominated by researchers from the University of Ottawa, there were two members associated with the University of Talca (Universidad de Talca; located in Chile), two members associated with the University of Montreal (Université de Montréal), and one member with McGill University (located in Montréal).

Now for these special hydrogels, from a May 13, 2024 University of Ottawa news release (also on EurekAlert) by David McFadden, Note: Links have been removed,

Combining biomedical finesse and nature-inspired engineering, a uOttawa-led team of scientists have created a jelly-like material that shows great potential for on-the-spot repair to a remarkable range of damaged organs and tissues in the human body.

Cutting-edge research co-led by uOttawa Faculty of Medicine  Associate Professor Dr. Emilio I. Alarcón could eventually impact millions of lives with peptide-based hydrogels that will close skin wounds, deliver therapeutics to damaged heart muscle, as well as reshape and heal injured corneas.

“We are using peptides to fabricate therapeutic solutions. The team is drawing inspiration from nature to develop simple solutions for wound closure and tissue repair,” says Dr. Alarcón, a scientist and director at the BioEngineering and Therapeutic Solutions (BEaTS) group at the University of Ottawa Heart Institutek whose innovative research work is focused on developing new materials with capabilities for tissue regeneration.

Peptides are molecules in living organisms and hydrogels are a water-based material with a gelatinous texture that have proven useful in therapeutics.

The approach used in the study –  just published in Advanced Functional Materials and co-led by Dr. Erik Suuronen & Dr. Marc Ruel – is unique. Most hydrogels explored in tissue engineering are animal-derived and protein-based materials, but the biomaterial created by the collaborative team is supercharged by engineered peptides. This makes it more clinically translatable.

Dr. Ruel, a full professor in the uOttawa Faculty of Medicine’s Department of Cellular and Molecular Medicine and the endowed chair of research in the Division of Cardiac Surgery at the University of Ottawa Heart Institute, says the study’s insights could be a game changer.

“Despite millennia of evolution, the human response to wound healing still remains imperfect,” Dr. Ruel says. “We see maladapted scarring in everything from skin incisions to eye injuries, to heart repair after a myocardial infarction. Drs. Alarcón, Suuronen, and the rest of our team have focused on this problem for almost two decades. The publication by Dr. Alarcón in Advanced Functional Materials reveals a novel way to make wound healing, organ healing, and even basic scarring after surgery much more therapeutically modulatable and, therefore, optimizable for human health.”

Indeed, the ability to modulate the peptide-based biomaterial is key. The uOttawa-led team’s hydrogels are designed to be customizable, making the durable material adaptable for use in a surprising range of tissues. Essentially, the two-component recipe could be adjusted to ramp up adhesivity or dial down other components depending on the part of the body needing repair.

“We were in fact very surprised by the range of applications our materials can achieve,” says Dr. Alarcón. “Our technology offers an integrated solution that is customizable depending on the targeted tissue.”

Dr. Alarcón says that not only does the study’s data suggest that the therapeutic action of the biomimetic hydrogels are highly effective, but its application is far simpler and cost-effective than other regenerative approaches.

The materials are engineered in a low-cost and scalable manner – hugely important qualities for any number of major biomedical applications. The team also devised a rapid-screening system that allowed them to significantly slash the design costs and testing timespans.

“This significant reduction in cost and time not only makes our material more economically viable but also accelerates its potential for clinical use,” Dr. Alarcón says.

What are next steps for the talent-rich research team? They will conduct large animal tests in preparation for tests in human subjects. So far, heart and skin tests were conducted with rodents, and the cornea work was done ex vivo.

Part of the work for this study was funded by the uOttawa Faculty of Medicine’s  “Path to Patenting & Pre-Commercialization” (3P),  an innovation-focused approach to provide our community’s top-flight researchers with the assistance needed to bring their most promising breakthroughs to the wider world.

Here’s a link to and a citation for the paper,

Multipurpose On-the-Spot Peptide-Based Hydrogels for Skin, Cornea, and Heart Repair by Alex Ross, Xixi Guo, German A. Mercado Salazar, Sergio David Garcia Schejtman, Jinane El-Hage, Maxime Comtois-Bona, Aidan Macadam, Irene Guzman-Soto, Hiroki Takaya, Kevin Hu, Bryan Liu, Ryan Tu, Bilal Siddiqi, Erica Anderson, Marcelo Muñoz, Patricio Briones-Rebolledo, Tianqin Ning, May Griffith, Benjamin Rotsein, Horacio Poblete, Jianyu Li, Marc Ruel, Erik J. Suuronen, Emilio I. Alarcon. Advanced Functional Materials DOI: https://doi.org/10.1002/adfm.202402564 First published: 23 April 2024

This paper is open access.

Fullertubes, at last!

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A theoretical possibility has been proven by an international team including researchers from the Université de Montréal (University of Montreal) according to a March 27, 2024 news item on phys.org,

For years, C130 fullertubes—molecules made up of 130 carbon atoms—have existed only in theory. Now, leading an international team of scientists, a UdeM doctoral student in physics has successfully shown them in real life—and even managed to capture some in a photograph.

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Illustration of the discovery of the C130-D5h molecule, published on the cover page of the prestigious “Journal of the American Chemical Society” last December. Credit: JACS

A March 27, 2024 Université de Montréal (UdeM) nouvelles (news release), which originated the news item, provides more detail, Note: Links have been removed,

This feat in the realm of basic research has led Emmanuel Bourret to have a cover-page illustration of his discovery in a prestigious scientific journal, the Journal of the American Chemical Society.

First published online last October [2023], the discovery was made by Bourret as lead scientist of an inter-university team that also included researchers from Purdue University, Virginia Tech and the Oak Ridge National Laboratory, in Tennessee.

A fullertube is basically an assembly of carbon atoms arranged to form a closed tubular cage. It is related to fullerenes, molecules that are represented as cages of interconnected hexagons and pentagons, and come in a wide variety of sizes and shapes.

For example, a C60 fullerene is made up of 60 carbon atoms and is shaped like a soccer ball. It is relatively small, spherical and very abundant. C120 fullerenes are less common. They are longer and shaped like a tube capped at either ends with the two halves of a C60 fullerene.

Found in soot

The C130 fullertube (or C130-D5h, its full scientific name) is more elongated than the C120 and even rarer. To isolate it, Bourret and his team generated an electric arc between two graphite electrodes to produce soot containing fullerene and fullertube molecules. The electronic structure of these molecules was then calculated using density functional theory (DFT).

“Drawing on principles of quantum mechanics, DFT enables us to calculate electronic structures and predict the properties of a molecule using the fundamental rules of physics,” explained Bourret’s thesis supervisor, UdeM physics professor Michel Côté, a researcher at the university’s Institut Courtois.

Using special software, Bourret was able to describe the structure of the C130 molecule: it is a tube with two hemispheres at the ends, making it look like a microscopic capsule. It measures just under 2 nanometres long by 1 nm wide (a nanometre is one billionth of a metre).

“The structure of the tube is basically made up of atoms arranged in hexagons,” said Bourret. “At the two ends, these hexagons are linked by pentagons, giving them their rounded shape.”

Bourret began doing theoretical work on fullertubes in 2014 under his then-supervisor Jiri Patera, an UdeM mathematics professor. After Patera passed away in January 2022, Bourret then approached Côté, who became his new supervisor.

Existence shown in 2020

Two years before that, Bourret had read an article by Purdue University at Fort Wayne professor Steven Stevenson, who described the experimental isolation of certain fullertubes, demonstrating their existence but not identifying all of them.

Under Côté’s guidance, Bourret set to work advancing knowledge on the topic.

“Emmanuel had a strong background in abstract mathematics,” Bourret recalled, “and he added an interesting dimension to my research group, which focuses on more computational approaches.”

Are any possible future applications in the offing?

“It’s hard to say at this stage, but one possibility might be the production of hydrogen,” said Côté. “Currently, what’s used is a catalyst made of platinum and rubidium, both of which are rare and expensive. Replacing them with carbon structures such as C130 would make it possible to produce hydrogen in a ‘greener’ way.”

Last year, Bourret’s groundbreaking work earned him an invitation to deliver a paper at the annual meeting of the U.S. Electrochemical Society (ECS), in Boston. This May [2024], he’ll chair a panel on fullerenes and fullertubes at the ECS annual meeting in San Francisco.

Here’s a link to and a citation for the paper,

Colossal C130 Fullertubes: Soluble [5,5] C130-D5h(1) Pristine Molecules with 70 Nanotube Carbons and Two 30-Atom Hemifullerene End-caps by Emmanuel Bourret, Xiaoyang Liu, Cora A. Noble, Kevin Cover, Tanisha P. Davidson, Rong Huang, Ryan M. Koenig, K. Shawn Reeves, Ivan V. Vlassiouk, Michel Côté, Jefferey S. Baxter, Andrew R. Lupini, David B. Geohegan, Harry C. Dorn, and Steven Stevenson. J. Am. Chem. Soc. 2023, 145, 48, 25942–25947 DOI: https://doi.org/10.1021/jacs.3c09082 Publication Date: October 27, 2023 Copyright © 2023 American Chemical Society

This paper is behind a paywall.

Hardware policies best way to manage AI safety?

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Regulation of artificial intelligence (AI) has become very topical in the last couple of years. There was an AI safety summit in November 2023 at Bletchley Park in the UK (see my November 2, 2023 posting for more about that international meeting).

A very software approach?

This year (2024) has seen a rise in legislative and proposed legislative activity. I have some articles on a few of these activities. China was the first to enact regulations of any kind on AI according to Matt Sheehan’s February 27, 2024 paper for the Carnegie Endowment for International Peace,

In 2021 and 2022, China became the first country to implement detailed, binding regulations on some of the most common applications of artificial intelligence (AI). These rules formed the foundation of China’s emerging AI governance regime, an evolving policy architecture that will affect everything from frontier AI research to the functioning of the world’s second-largest economy, from large language models in Africa to autonomous vehicles in Europe.

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The Chinese Communist Party (CCP) and the Chinese government started that process with the 2021 rules on recommendation algorithms, an omnipresent use of the technology that is often overlooked in international AI governance discourse. Those rules imposed new obligations on companies to intervene in content recommendations, granted new rights to users being recommended content, and offered protections to gig workers subject to algorithmic scheduling. The Chinese party-state quickly followed up with a new regulation on “deep synthesis,” the use of AI to generate synthetic media such as deepfakes. Those rules required AI providers to watermark AI-generated content and ensure that content does not violate people’s “likeness rights” or harm the “nation’s image.” Together, these two regulations also created and amended China’s algorithm registry, a regulatory tool that would evolve into a cornerstone of the country’s AI governance regime.

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The UK has adopted a more generalized approach focused on encouraging innovation according to Valeria Gallo’s and Suchitra Nair’s February 21, 2024 article for Deloitte (a British professional services firm also considered one of the big four accounting firms worldwide),

At a glance

The UK Government has adopted a cross-sector and outcome-based framework for regulating AI, underpinned by five core principles. These are safety, security and robustness, appropriate transparency and explainability, fairness, accountability and governance, and contestability and redress.

Regulators will implement the framework in their sectors/domains by applying existing laws and issuing supplementary regulatory guidance. Selected regulators will publish their AI annual strategic plans by 30th April [2024], providing businesses with much-needed direction.

Voluntary safety and transparency measures for developers of highly capable AI models and systems will also supplement the framework and the activities of individual regulators.

The framework will not be codified into law for now, but the Government anticipates the need for targeted legislative interventions in the future. These interventions will address gaps in the current regulatory framework, particularly regarding the risks posed by complex General Purpose AI and the key players involved in its development.

Organisations must prepare for increased AI regulatory activity over the next year, including guidelines, information gathering, and enforcement. International firms will inevitably have to navigate regulatory divergence.

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While most of the focus appears to be on the software (e.g., General Purpose AI), the UK framework does not preclude hardware.

The European Union (EU) is preparing to pass its own AI regulation act through the European Parliament in 2024 according to a December 19, 2023 “EU AI Act: first regulation on artificial intelligence” article update, Note: Links have been removed,

As part of its digital strategy, the EU wants to regulate artificial intelligence (AI) to ensure better conditions for the development and use of this innovative technology. AI can create many benefits, such as better healthcare; safer and cleaner transport; more efficient manufacturing; and cheaper and more sustainable energy.

In April 2021, the European Commission proposed the first EU regulatory framework for AI. It says that AI systems that can be used in different applications are analysed and classified according to the risk they pose to users. The different risk levels will mean more or less regulation.

The agreed text is expected to be finally adopted in April 2024. It will be fully applicable 24 months after entry into force, but some parts will be applicable sooner:

*The ban of AI systems posing unacceptable risks will apply six months after the entry into force

*Codes of practice will apply nine months after entry into force

*Rules on general-purpose AI systems that need to comply with transparency requirements will apply 12 months after the entry into force

High-risk systems will have more time to comply with the requirements as the obligations concerning them will become applicable 36 months after the entry into force.

…

This EU initiative, like the UK framework, seems largely focused on AI software and according to the Wikipedia entry “Regulation of artificial intelligence,”

… The AI Act is expected to come into effect in late 2025 or early 2026.[109

I do have a few postings about Canadian regulatory efforts, which also seem to be focused on software but don’t preclude hardware. While the January 20, 2024 posting is titled “Canada’s voluntary code of conduct relating to advanced generative AI (artificial intelligence) systems,” information about legislative efforts is also included although you might find my May 1, 2023 posting titled “Canada, AI regulation, and the second reading of the Digital Charter Implementation Act, 2022 (Bill C-27)” offers more comprehensive information about Canada’s legislative progress or lack thereof.

The US is always to be considered in these matters and I have a November 2023 ‘briefing’ by Müge Fazlioglu on the International Association of Privacy Professionals (IAPP) website where she provides a quick overview of the international scene before diving deeper into US AI governance policy through the Barack Obama, Donald Trump, and Joe Biden administrations. There’s also this January 29, 2024 US White House “Fact Sheet: Biden-⁠Harris Administration Announces Key AI Actions Following President Biden’s Landmark Executive Order.”

What about AI and hardware?

A February 15, 2024 news item on ScienceDaily suggests that regulating hardware may be the most effective way of regulating AI,

Chips and datacentres — the ‘compute’ power driving the AI revolution — may be the most effective targets for risk-reducing AI policies as they have to be physically possessed, according to a new report.

A global registry tracking the flow of chips destined for AI supercomputers is one of the policy options highlighted by a major new report calling for regulation of “compute” — the hardware that underpins all AI — to help prevent artificial intelligence misuse and disasters.

Other technical proposals floated by the report include “compute caps” — built-in limits to the number of chips each AI chip can connect with — and distributing a “start switch” for AI training across multiple parties to allow for a digital veto of risky AI before it feeds on data.

The experts point out that powerful computing chips required to drive generative AI models are constructed via highly concentrated supply chains, dominated by just a handful of companies — making the hardware itself a strong intervention point for risk-reducing AI policies.

The report, published 14 February [2024], is authored by nineteen experts and co-led by three University of Cambridge institutes — the Leverhulme Centre for the Future of Intelligence (LCFI), the Centre for the Study of Existential Risk (CSER) and the Bennett Institute for Public Policy — along with OpenAI and the Centre for the Governance of AI.

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A February 14, 2024 University of Cambridge press release by Fred Lewsey (also on EurekAlert), which originated the news item, provides more information about the ‘hardware approach to AI regulation’,

“Artificial intelligence has made startling progress in the last decade, much of which has been enabled by the sharp increase in computing power applied to training algorithms,” said Haydn Belfield, a co-lead author of the report from Cambridge’s LCFI. 

“Governments are rightly concerned about the potential consequences of AI, and looking at how to regulate the technology, but data and algorithms are intangible and difficult to control.

“AI supercomputers consist of tens of thousands of networked AI chips hosted in giant data centres often the size of several football fields, consuming dozens of megawatts of power,” said Belfield.

“Computing hardware is visible, quantifiable, and its physical nature means restrictions can be imposed in a way that might soon be nearly impossible with more virtual elements of AI.”

The computing power behind AI has grown exponentially since the “deep learning era” kicked off in earnest, with the amount of “compute” used to train the largest AI models doubling around every six months since 2010. The biggest AI models now use 350 million times more compute than thirteen years ago.

Government efforts across the world over the past year – including the US Executive Order on AI, EU AI Act, China’s Generative AI Regulation, and the UK’s AI Safety Institute – have begun to focus on compute when considering AI governance.

Outside of China, the cloud compute market is dominated by three companies, termed “hyperscalers”: Amazon, Microsoft, and Google. “Monitoring the hardware would greatly help competition authorities in keeping in check the market power of the biggest tech companies, and so opening the space for more innovation and new entrants,” said co-author Prof Diane Coyle from Cambridge’s Bennett Institute. 

The report provides “sketches” of possible directions for compute governance, highlighting the analogy between AI training and uranium enrichment. “International regulation of nuclear supplies focuses on a vital input that has to go through a lengthy, difficult and expensive process,” said Belfield. “A focus on compute would allow AI regulation to do the same.”

Policy ideas are divided into three camps: increasing the global visibility of AI computing; allocating compute resources for the greatest benefit to society; enforcing restrictions on computing power.

For example, a regularly-audited international AI chip registry requiring chip producers, sellers, and resellers to report all transfers would provide precise information on the amount of compute possessed by nations and corporations at any one time.

The report even suggests a unique identifier could be added to each chip to prevent industrial espionage and “chip smuggling”.

“Governments already track many economic transactions, so it makes sense to increase monitoring of a commodity as rare and powerful as an advanced AI chip,” said Belfield. However, the team point out that such approaches could lead to a black market in untraceable “ghost chips”.

Other suggestions to increase visibility – and accountability – include reporting of large-scale AI training by cloud computing providers, and privacy-preserving “workload monitoring” to help prevent an arms race if massive compute investments are made without enough transparency.  

“Users of compute will engage in a mixture of beneficial, benign and harmful activities, and determined groups will find ways to circumvent restrictions,” said Belfield. “Regulators will need to create checks and balances that thwart malicious or misguided uses of AI computing.”

These might include physical limits on chip-to-chip networking, or cryptographic technology that allows for remote disabling of AI chips in extreme circumstances. One suggested approach would require the consent of multiple parties to unlock AI compute for particularly risky training runs, a mechanism familiar from nuclear weapons.

AI risk mitigation policies might see compute prioritised for research most likely to benefit society – from green energy to health and education. This could even take the form of major international AI “megaprojects” that tackle global issues by pooling compute resources.

The report’s authors are clear that their policy suggestions are “exploratory” rather than fully fledged proposals and that they all carry potential downsides, from risks of proprietary data leaks to negative economic impacts and the hampering of positive AI development.

They offer five considerations for regulating AI through compute, including the exclusion of small-scale and non-AI computing, regular revisiting of compute thresholds, and a focus on privacy preservation.

Added Belfield: “Trying to govern AI models as they are deployed could prove futile, like chasing shadows. Those seeking to establish AI regulation should look upstream to compute, the source of the power driving the AI revolution. If compute remains ungoverned it poses severe risks to society.”

You can find the report, “Computing Power and the Governance of Artificial Intelligence” on the University of Cambridge’s Centre for the Study of Existential Risk.

Authors include: Girish Sastry, Lennart Heim, Haydn Belfield, Markus Anderljung, Miles Brundage, Julian Hazell, Cullen O’Keefe, Gillian K. Hadfield, Richard Ngo, Konstantin Pilz, George Gor, Emma Bluemke, Sarah Shoker, Janet Egan, Robert F. Trager, Shahar Avin, Adrian Weller, Yoshua Bengio, and Diane Coyle.

The authors are associated with these companies/agencies: OpenAI, Centre for the Governance of AI (GovAI), Leverhulme Centre for the Future of Intelligence at the Uni. of Cambridge, Oxford Internet Institute, Institute for Law & AI, University of Toronto Vector Institute for AI, Georgetown University, ILINA Program, Harvard Kennedy School (of Government), *AI Governance Institute,* Uni. of Oxford, Centre for the Study of Existential Risk at Uni. of Cambridge, Uni. of Cambridge, Uni. of Montreal / Mila, Bennett Institute for Public Policy at the Uni. of Cambridge.

“The ILINIA program is dedicated to providing an outstanding platform for Africans to learn and work on questions around maximizing wellbeing and responding to global catastrophic risks” according to the organization’s homepage.

*As for the AI Governance Institute, I believe that should be the Centre for the Governance of AI at Oxford University since the associated academic is Robert F. Trager from the University of Oxford.

As the months (years?) fly by, I guess we’ll find out if this hardware approach gains any traction where AI regulation is concerned.

Researchers at University of Montéal decode how molecules “talk” to each

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An August 15, 2023 news item on ScienceDaily breaks news from the University of Montréal,

Two molecular languages at the origin of life have been successfully recreated and mathematically validated, thanks to pioneering work by Canadian scientists at Université de Montréal.

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Fascinating, non? An August 15, 2023 Université de Montréal news release (also on EurekAlert), which originated the news item, explaining how this leads to nanotechnology-enabled applications, Note: A link has been removed,

Published this week in the Journal of American Chemical Society, the breakthrough opens new doors for the development of nanotechnologies with applications ranging from biosensing, drug delivery and molecular imaging.

Living organisms are made up of billions of nanomachines and nanostructures that communicate to create higher-order entities able to do many essential things, such as moving, thinking, surviving and reproducing.

“The key to life’s emergence relies on the development of molecular languages – also called signalling mechanisms – which ensure that all molecules in living organisms are working together to achieve specific tasks,” said the study’s principal investigator, UdeM bioengineering professor Alexis Vallée-Bélisle.

In yeasts, for example, upon detecting and binding a mating pheromone, billions of molecules will communicate and coordinate their activities to initiate union, said Vallée-Bélisle, holder of a Canada Research Chair in Bioengineering and Bionanotechnology.

“As we enter the era of nanotechnology, many scientists believe that the key to designing and programming more complex and useful artificial nanosystems relies on our ability to understand and better employ molecular languages developed by living organisms,” he said.

Two types of languages

One well-known molecular language is allostery. The mechanism of this language is “lock-and-key”: a molecule binds and modifies the structure of another molecule, directing it to trigger or inhibit an activity.

Another, lesser-known molecular language is multivalency, also known as the chelate effect. It works like a puzzle: as one molecule binds to another, it facilitates (or not) the binding of a third molecule by simply increasing its binding interface.

Although these two languages are observed in all molecular systems of all living organisms, it is only recently that scientists have started to understand their rules and principles – and so use these languages to design and program novel artificial nanotechnologies.

“Given the complexity of natural nanosystems, before now nobody was able to compare the basic rules, advantage or limitations of these two languages on the same system,” said Vallée-Bélisle.

To do so, his doctoral student Dominic Lauzon, first author of the study, had the idea of creating a DNA-based molecular system that could function using both languages. “DNA is like Lego bricks for nanoengineers,” said Lauzon. “It’s a remarkable molecule that offers simple, programmable and easy-to-use chemistry.”

Simple mathematical equations to detect antibodies

The researchers found that simple mathematical equations could well describe both languages, which unravelled the parameters and design rules to program the communication between molecules within a nanosystem.

For example, while the multivalent language enabled control of both the sensitivity and cooperativity of the activation or deactivation of the molecules, the corresponding allosteric translation only enabled control of the sensitivity of the response.

With this new understanding at hand, the researchers used the language of multivalency to design and engineer a programmable antibody sensor that allows the detection of antibodies over different ranges of concentration.

“As shown with the recent pandemic, our ability to precisely monitor the concentration of antibodies in the general population is a powerful tool to determine the people’s individual and collective immunity,” said Vallée-Bélisle.

In addition to expanding the synthetic toolbox to create the next generation of nanotechnology, the scientist’s discovery also shines a light on why some natural nanosystems may have selected one language over another to communicate chemical information.

Caption; The illustration depicts two chemical languages at the basis of molecular communication. The same white molecule, represented as a lock, is activated either via allostery (top) or multivalency (bottom). The allosteric activator (cyan) induces a conformational change of the lock while the multivalent activator provides the missing part of the lock, both enabling the activation by the key (pink). Credit: Monney Medical Media / Caitlin Monney

Here’s a link to and a citation for the paper,

Programing Chemical Communication: Allostery vs Multivalent Mechanism by Dominic Lauzon and Alexis Vallée-Bélisle. J. Am. Chem. Soc. 2023, XXXX, XXX, XXX-XXX DOI: https://doi.org/10.1021/jacs.3c04045 Online Publication Date: August 15, 2023 © 2023 American Chemical Society

This paper is behind a paywall.

Phytoremediation with lupin and arsenic

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Is anyone else reminded of Arsène Lupin? (More about Lupin later in this posing)

An August 24, 2021 news item on ScienceDaily describes research on soils and phytoremediation (decontamination by plants),

Pollution of soils with highly toxic arsenic is a worldwide problem generating substantial risks to human health and the environment.

In Canada, over 7000 sites contaminated with metals such as arsenic are considered ‘highly concerning’ by the government, with some past and recent mining operations and wood preservative facilities having left their mark on the environment by increasing soil arsenic levels by up to 1000 times the maximum regulatory health limits.

One way in which arsenic contaminated soils could be rejuvenated is to exploit natural mechanisms which have evolved in certain plants for contamination tolerance.

“The legume crop white lupin (L. albus) is one such arsenic tolerant plant species being studied as for sustainable remediation,” explains Adrien Frémont, lead author of the study and a doctoral student in biological sciences at the Université de Montréal. “The mechanism behind arsenic tolerance in white lupin is thought to be the release of plant chemicals directly into soil by roots, but the nature of these compounds is unknown and hard to study due to the complexity of these belowground interactions.”

Caption: The legume crop white lupin (L. albus) is one such arsenic tolerant plant species being studied as for sustainable remediation. Credit: UMONTREAL

An August 24, 2021 University of Montreal (Université de Montréal) news release (also on EurekAlert), which originated the news item, describes the work in more detail,

Root chemicals an undiscovered country

To study this, the team developed nylon pouches which could be placed close to roots in soil to capture exuded molecules without damaging the root system. The complex mix of molecules collected from these pouches were analysed using advanced (metabolomic) chemical profiling to identify the compounds capable of binding metals produced by the Lupin plants in response to high concentrations of arsenic. Some of these metal-binding molecules, phytochelatins, are known to be used internally by plants to deal with metal stress but have never before been captured as exuded into polluted soils.

“We’re really excited to see how matching new root-soil sampling approaches with advanced metabolomic profiling can yield such unexpected discoveries”, notes Frémont. “We know that plants can drastically change soil properties and can transform or immobilise soil pollution, but the chemistry underlying how they achieve this, and in particular the makeup and function of root-exuded compounds, is still very much an undiscovered country.”
 

Plant roots directly altering polluted soils

The next steps of the research are to branch out into more detailed analysis of the precise chemical reactions taking place at the root-soil interface, including exploration of different plant species, interactions with microorganisms and the challenge of diverse soil pollution.

As Dr. Nicholas Brereton, University of Montreal and the study’s senior author, mentions: “It can be a real challenge to research the complex interactions going on belowground between plants and soil, but these findings are rewarding in telling us that natural mechanisms have evolved in plants to deal with this type of pollution. Although we’re still only just beginning to scratch below the surface of how these plant root strategies work, as we learn more, we can potentially utilise these natural processes to improve soil health and help to alleviate some of the most persistent anthropogenic damage to our environment.”

Here’s a link to and a citation for the paper,

Phytochelatin and coumarin enrichment in root exudates of arsenic-treated white lupin by Adrien Frémont, Eszter Sas, Mathieu Sarrazin, Emmanuel Gonzalez, Jacques Brisson, Frédéric Emmanuel Pitre, Nicholas James Beresford Brereton. Plant Cell & Environment DOI: https://doi.org/10.1111/pce.14163 First published: 15 August 2021

This paper is behind a paywall.

For anyone interested in phytoremediation, I have a March 30, 2012 posting about it and there’s this Wikipedia entry. Depending on the circumstances, you might also consider phytoremediation as a form of phyto-mining, i.e., using plants to recover metals from mine tailings (see my March 5, 2013 posting).

Arsène Lupin

There are two of them (the first and the latest ones) being mentioned here; but there are many versions of Arsène Lupin in manga, anime, movies, etc.

The first fictional Arsène Lupin was created in 1905 by Maurice Leblanc. Here’s a description (on the Normandie tourisme website) of the first Lupin in an article about the latest Lupin, a series streamed on Netflix.

…

Maurice Leblanc was born in Rouen in 1864. Fascinated by legends of witches, Celts, Romans and the Vikings growing up, Leblanc would go on to develop a deep knowledge of and love for the region around Rouen, known as the Pays de Caux. After working in a factory in Rouen by day, writing only in his spare time, Leblanc eventually left his home town to study in Paris, where he then started working as a journalist for several publications including Le Figaro. Fate then struck, as publisher Pierre Lafitte launched the magazine Je sais tout and commissioned Leblanc to write a series of new crime stories where the hero would be a sort of French anti-Sherlock Holmes.

Who was the original Lupin? Not unlike Lupin in the TV series, the Arsène Lupin of the books was a thief, a master of disguise, a rascal but never a killer, a hit with the ladies and a righter of wrongs who takes from the rich, a French Robin Hood if you like. He takes on a multitude of personas in the books, constantly changing his looks and his name – examples include Prince Paul Sernine, Raoul d’Andrésy, Horace Velmont and Don Luis Perenna. In the [Lupin] series [2021], this is echoed by Assane’s alter-egos Paul Sernine, Luis Perenna and Salvatore813, as well as his choice of name for his son, Raoul. Yet superman Lupin, both in the books and on screen, always manages to triumph somehow over his enemies, even when all seems lost, through bending the rules, outsmarting the police and sheer self-belief.

You can find out more about the latest Lupin in its IMDb entry,

Inspired by the adventures of Arsène Lupin, gentleman thief Assane Diop sets out to avenge his father for an injustice inflicted by a wealthy family.

The television series starring Omar Sy was a huge hit in France and has been seen worldwide.

Council of Canadian Academies and its expert panel for the AI for Science and Engineering project

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There seems to be an explosion (metaphorically and only by Canadian standards) of interest in public perceptions/engagement/awareness of artificial intelligence (see my March 29, 2021 posting “Canada launches its AI dialogues” and these dialogues run until April 30, 2021 plus there’s this April 6, 2021 posting “UNESCO’s Call for Proposals to highlight blind spots in AI Development open ’til May 2, 2021” which was launched in cooperation with Mila-Québec Artificial Intelligence Institute).

Now there’s this, in a March 31, 2020 Council of Canadian Academies (CCA) news release, four new projects were announced. (Admittedly these are not ‘public engagement’ exercises as such but the reports are publicly available and utilized by policymakers.) These are the two projects of most interest to me,

Public Safety in the Digital Age

Information and communications technologies have profoundly changed almost every aspect of life and business in the last two decades. While the digital revolution has brought about many positive changes, it has also created opportunities for criminal organizations and malicious actors to target individuals, businesses, and systems.

This assessment will examine promising practices that could help to address threats to public safety related to the use of digital technologies while respecting human rights and privacy.

Sponsor: Public Safety Canada

AI for Science and Engineering

The use of artificial intelligence (AI) and machine learning in science and engineering has the potential to radically transform the nature of scientific inquiry and discovery and produce a wide range of social and economic benefits for Canadians. But, the adoption of these technologies also presents a number of potential challenges and risks.

This assessment will examine the legal/regulatory, ethical, policy and social challenges related to the use of AI technologies in scientific research and discovery.

Sponsor: National Research Council Canada [NRC] (co-sponsors: CIFAR [Canadian Institute for Advanced Research], CIHR [Canadian Institutes of Health Research], NSERC [Natural Sciences and Engineering Research Council], and SSHRC [Social Sciences and Humanities Research Council])

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For today’s posting the focus will be on the AI project, specifically, the April 19, 2021 CCA news release announcing the project’s expert panel,

The Council of Canadian Academies (CCA) has formed an Expert Panel to examine a broad range of factors related to the use of artificial intelligence (AI) technologies in scientific research and discovery in Canada. Teresa Scassa, SJD, Canada Research Chair in Information Law and Policy at the University of Ottawa, will serve as Chair of the Panel.  

“AI and machine learning may drastically change the fields of science and engineering by accelerating research and discovery,” said Dr. Scassa. “But these technologies also present challenges and risks. A better understanding of the implications of the use of AI in scientific research will help to inform decision-making in this area and I look forward to undertaking this assessment with my colleagues.”

As Chair, Dr. Scassa will lead a multidisciplinary group with extensive expertise in law, policy, ethics, philosophy, sociology, and AI technology. The Panel will answer the following question:

What are the legal/regulatory, ethical, policy and social challenges associated with deploying AI technologies to enable scientific/engineering research design and discovery in Canada?

“We’re delighted that Dr. Scassa, with her extensive experience in AI, the law and data governance, has taken on the role of Chair,” said Eric M. Meslin, PhD, FRSC, FCAHS, President and CEO of the CCA. “I anticipate the work of this outstanding panel will inform policy decisions about the development, regulation and adoption of AI technologies in scientific research, to the benefit of Canada.”

The CCA was asked by the National Research Council of Canada (NRC), along with co-sponsors CIFAR, CIHR, NSERC, and SSHRC, to address the question. More information can be found here.

The Expert Panel on AI for Science and Engineering:

Teresa Scassa (Chair), SJD, Canada Research Chair in Information Law and Policy, University of Ottawa, Faculty of Law (Ottawa, ON)

Julien Billot, CEO, Scale AI (Montreal, QC)

Wendy Hui Kyong Chun, Canada 150 Research Chair in New Media and Professor of Communication, Simon Fraser University (Burnaby, BC)

Marc Antoine Dilhac, Professor (Philosophy), University of Montreal; Director of Ethics and Politics, Centre for Ethics (Montréal, QC)

B. Courtney Doagoo, AI and Society Fellow, Centre for Law, Technology and Society, University of Ottawa; Senior Manager, Risk Consulting Practice, KPMG Canada (Ottawa, ON)

Abhishek Gupta, Founder and Principal Researcher, Montreal AI Ethics Institute (Montréal, QC)

Richard Isnor, Associate Vice President, Research and Graduate Studies, St. Francis Xavier University (Antigonish, NS)

Ross D. King, Professor, Chalmers University of Technology (Göteborg, Sweden)

Sabina Leonelli, Professor of Philosophy and History of Science, University of Exeter (Exeter, United Kingdom)

Raymond J. Spiteri, Professor, Department of Computer Science, University of Saskatchewan (Saskatoon, SK)

Who is the expert panel?

Putting together a Canadian panel is an interesting problem especially so when you’re trying to find people of expertise who can also represent various viewpoints both professionally and regionally. Then, there are gender, racial, linguistic, urban/rural, and ethnic considerations.

Statistics

Eight of the panelists could be said to be representing various regions of Canada. Five of those eight panelists are based in central Canada, specifically, Ontario (Ottawa) or Québec (Montréal). The sixth panelist is based in Atlantic Canada (Nova Scotia), the seventh panelist is based in the Prairies (Saskatchewan), and the eighth panelist is based in western Canada, (Vancouver, British Columbia).

The two panelists bringing an international perspective to this project are both based in Europe, specifically, Sweden and the UK.

(sigh) It would be good to have representation from another part of the world. Asia springs to mind as researchers in that region are very advanced in their AI research and applications meaning that their experts and ethicists are likely to have valuable insights.

Four of the ten panelists are women, which is closer to equal representation than some of the other CCA panels I’ve looked at.

As for Indigenous and BIPOC representation, unless one or more of the panelists chooses to self-identify in that fashion, I cannot make any comments. It should be noted that more than one expert panelist focuses on social justice and/or bias in algorithms.

Network of relationships

As you can see, the CCA descriptions for the individual members of the expert panel are a little brief. So, I did a little digging and In my searches, I noticed what seems to be a pattern of relationships among some of these experts. In particular, take note of the Canadian Institute for Advanced Research (CIFAR) and the AI Advisory Council of the Government of Canada.

Individual panelists

Teresa Scassa (Ontario) whose SJD designation signifies a research doctorate in law chairs this panel. Offhand, I can recall only one or two other panels being chaired by women of the 10 or so I’ve reviewed. In addition to her profile page at the University of Ottawa, she hosts her own blog featuring posts such as “How Might Bill C-11 Affect the Outcome of a Clearview AI-type Complaint?” She writes clearly (I didn’t seen any jargon) for an audience that is somewhat informed on the topic.

Along with Dilhac, Teresa Scassa is a member of the AI Advisory Council of the Government of Canada. More about that group when you read Dilhac’s description.

Julien Billot (Québec) has provided a profile on LinkedIn and you can augment your view of M. Billot with this profile from the CreativeDestructionLab (CDL),

Mr. Billot is a member of the faculty at HEC Montréal [graduate business school of the Université de Montréal] as an adjunct professor of management and the lead for the CreativeDestructionLab (CDL) and NextAi program in Montreal.

Julien Billot has been President and Chief Executive Officer of Yellow Pages Group Corporation (Y.TO) in Montreal, Quebec. Previously, he was Executive Vice President, Head of Media and Member of the Executive Committee of Solocal Group (formerly PagesJaunes Groupe), the publicly traded and incumbent local search business in France. Earlier experience includes serving as CEO of the digital and new business group of Lagardère Active, a multimedia branch of Lagardère Group and 13 years in senior management positions at France Telecom, notably as Chief Marketing Officer for Orange, the company’s mobile subsidiary.

…

Mr. Billot is a graduate of École Polytechnique (Paris) and from Telecom Paris Tech. He holds a postgraduate diploma (DEA) in Industrial Economics from the University of Paris-Dauphine.

Wendy Hui Kyong Chun (British Columbia) has a profile on the Simon Fraser University (SFU) website, which provided one of the more interesting (to me personally) biographies,

Wendy Hui Kyong Chun is the Canada 150 Research Chair in New Media at Simon Fraser University, and leads the Digital Democracies Institute which was launched in 2019. The Institute aims to integrate research in the humanities and data sciences to address questions of equality and social justice in order to combat the proliferation of online “echo chambers,” abusive language, discriminatory algorithms and mis/disinformation by fostering critical and creative user practices and alternative paradigms for connection. It has four distinct research streams all led by Dr. Chun: Beyond Verification which looks at authenticity and the spread of disinformation; From Hate to Agonism, focusing on fostering democratic exchange online; Desegregating Network Neighbourhoods, combatting homophily across platforms; and Discriminating Data: Neighbourhoods, Individuals and Proxies, investigating the centrality of race, gender, class and sexuality [emphasis mine] to big data and network analytics.

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I’m glad to see someone who has focused on ” … the centrality of race, gender, class and sexuality to big data and network analytics.” Even more interesting to me was this from her CV (curriculum vitae),

Professor, Department of Modern Culture and Media, Brown University, July 2010-June 2018

.•Affiliated Faculty, Multimedia & Electronic Music Experiments (MEME), Department of Music,2017.

•Affiliated Faculty, History of Art and Architecture, March 2012-

.•Graduate Field Faculty, Theatre Arts and Performance Studies, Sept 2008-.[sic]

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[all emphases mine]

And these are some of her credentials,

Ph.D., English, Princeton University, 1999.
•Certificate, School of Criticism and Theory, Dartmouth College, Summer 1995.

M.A., English, Princeton University, 1994.

B.A.Sc., Systems Design Engineering and English, University of Waterloo, Canada, 1992.
•first class honours and a Senate Commendation for Excellence for being the first student to graduate from the School of Engineering with a double major

It’s about time the CCA started integrating some of kind of arts perspective into their projects. (Although, I can’t help wondering if this was by accident rather than by design.)

Marc Antoine Dilhac, an associate professor at l’Université de Montréal, he, like Billot, graduated from a French university, in his case, the Sorbonne. Here’s more from Dilhac’s profile on the Mila website,

Marc-Antoine Dilhac (Ph.D., Paris 1 Panthéon-Sorbonne) is a professor of ethics and political philosophy at the Université de Montréal and an associate member of Mila – Quebec Artificial Intelligence Institute. He currently holds a CIFAR [Canadian Institute for Advanced Research] Chair in AI ethics (2019-2024), and was previously Canada Research Chair in Public Ethics and Political Theory 2014-2019. He specialized in theories of democracy and social justice, as well as in questions of applied ethics. He published two books on the politics of toleration and inclusion (2013, 2014). His current research focuses on the ethical and social impacts of AI and issues of governance and institutional design, with a particular emphasis on how new technologies are changing public relations and political structures.

In 2017, he instigated the project of the Montreal Declaration for a Responsible Development of AI and chaired its scientific committee. In 2020, as director of Algora Lab, he led an international deliberation process as part of UNESCO’s consultation on its recommendation on the ethics of AI.

In 2019, he founded Algora Lab, an interdisciplinary laboratory advancing research on the ethics of AI and developing a deliberative approach to the governance of AI and digital technologies. He is co-director of Deliberation at the Observatory on the social impacts of AI and digital technologies (OBVIA), and contributes to the OECD Policy Observatory (OECD.AI) as a member of its expert network ONE.AI.

He sits on the AI Advisory Council of the Government of Canada and co-chair its Working Group on Public Awareness.

Formerly known as Mila only, Mila – Quebec Artificial Intelligence Institute is a beneficiary of the 2017 Canadian federal budget’s inception of the Pan-Canadian Artificial Intelligence Strategy, which named CIFAR as an agency that would benefit as the hub and would also distribute funds for artificial intelligence research to (mainly) three agencies: Mila in Montréal, the Vector Institute in Toronto, and the Alberta Machine Intelligence Institute (AMII; Edmonton).

Consequently, Dilhac’s involvement with CIFAR is not unexpected but when added to his presence on the AI Advisory Council of the Government of Canada and his role as co-chair of its Working Group on Public Awareness, one of the co-sponsors for this future CCA report, you get a sense of just how small the Canadian AI ethics and public awareness community is.

Add in CIFAR’s Open Dialogue: AI in Canada series (ongoing until April 30, 2021) which is being held in partnership with the AI Advisory Council of the Government of Canada (see my March 29, 2021 posting for more details about the dialogues) amongst other familiar parties and you see a web of relations so tightly interwoven that if you could produce masks from it you’d have superior COVID-19 protection to N95 masks.

These kinds of connections are understandable and I have more to say about them in my final comments.

B. Courtney Doagoo has a profile page at the University of Ottawa, which fills in a few information gaps,

As a Fellow, Dr. Doagoo develops her research on the social, economic and cultural implications of AI with a particular focus on the role of laws, norms and policies [emphasis mine]. She also notably advises Dr. Florian Martin-Bariteau, CLTS Director, in the development of a new research initiative on those topical issues, and Dr. Jason Millar in the development of the Canadian Robotics and Artificial Intelligence Ethical Design Lab (CRAiEDL).

Dr. Doagoo completed her Ph.D. in Law at the University of Ottawa in 2017. In her interdisciplinary research, she used empirical methods to learn about and describe the use of intellectual property law and norms in creative communities. Following her doctoral research, she joined the World Intellectual Property Organization’s Coordination Office in New York as a legal intern and contributed to developing the joint initiative on gender and innovation in collaboration with UNESCO and UN Women. She later joined the International Law Research Program at the Centre for International Governance Innovation as a Post-Doctoral Fellow, where she conducted research in technology and law focusing on intellectual property law, artificial intelligence and data governance.

Dr. Doagoo completed her LL.L. at the University of Ottawa, and LL.M. in Intellectual Property Law at the Benjamin N. Cardozo School of Law [a law school at Yeshiva University in New York City].  In between her academic pursuits, Dr. Doagoo has been involved with different technology start-ups, including the one she is currently leading aimed at facilitating access to legal services. She’s also an avid lover of the arts and designed a course on Arts and Cultural Heritage Law taught during her doctoral studies at the University of Ottawa, Faculty of Law.

It’s probably because I don’t know enough but this “the role of laws, norms and policies” seems bland to the point of meaningless. The rest is more informative and brings it back to the arts with Wendy Hui Kyong Chun at SFU.

Doagoo’s LinkedIn profile offers an unexpected link to this expert panel’s chairperson, Teresa Scassa (in addition to both being lawyers whose specialties are in related fields and on faculty or fellow at the University of Ottawa),

Soft-funded Research Bursary

Dr. Teresa Scassa

2014

I’m not suggesting any conspiracies; it’s simply that this is a very small community with much of it located in central and eastern Canada and possible links into the US. For example, Wendy Hui Kyong Chun, prior to her SFU appointment in December 2018, worked and studied in the eastern US for over 25 years after starting her academic career at the University of Waterloo (Ontario).

Abhishek Gupta provided me with a challenging search. His LinkedIn profile yielded some details (I’m not convinced the man sleeps), Note: I have made some formatting changes and removed the location, ‘Montréal area’ from some descriptions

Experience

Microsoft Graphic
Software Engineer II – Machine Learning
Microsoft

Jul 2018 – Present – 2 years 10 months

Machine Learning – Commercial Software Engineering team

Serves on the CSE Responsible AI Board

Founder and Principal Researcher
Montreal AI Ethics Institute

May 2018 – Present – 3 years

Institute creating tangible and practical research in the ethical, safe and inclusive development of AI. For more information, please visit https://montrealethics.ai

Visiting AI Ethics Researcher, Future of Work, International Visitor Leadership Program
U.S. Department of State

Aug 2019 – Present – 1 year 9 months

Selected to represent Canada on the future of work

Responsible AI Lead, Data Advisory Council
Northwest Commission on Colleges and Universities

Jun 2020 – Present – 11 months

Faculty Associate, Frankfurt Big Data Lab
Goethe University

Mar 2020 – Present – 1 year 2 months

Advisor for the Z-inspection project

Associate Member
LF AI Foundation

May 2020 – Present – 1 year

Author
MIT Technology Review

Sep 2020 – Present – 8 months

Founding Editorial Board Member, AI and Ethics Journal
Springer Nature

Jul 2020 – Present – 10 months

…

Education

McGill University Bachelor of Science (BS)Computer Science

2012 – 2015

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Exhausting, eh? He also has an eponymous website and the Montreal AI Ethics Institute can found here where Gupta and his colleagues are “Democratizing AI ethics literacy.” My hat’s off to Gupta getting on an expert panel for CCA is quite an achievement for someone without the usual academic and/or industry trappings.

Richard Isnor, based in Nova Scotia and associate vice president of research & graduate studies at St. Francis Xavier University (StFX), seems to have some connection to northern Canada (see the reference to Nunavut Research Institute below); he’s certainly well connected to various federal government agencies according to his profile page,

Prior to joining StFX, he was Manager of the Atlantic Regional Office for the Natural Sciences and Engineering Research Council of Canada (NSERC), based in Moncton, NB.  Previously, he was Director of Innovation Policy and Science at the International Development Research Centre in Ottawa and also worked for three years with the National Research Council of Canada [NRC] managing Biotechnology Research Initiatives and the NRC Genomics and Health Initiative.

Richard holds a D. Phil. in Science and Technology Policy Studies from the University of Sussex, UK; a Master’s in Environmental Studies from Dalhousie University [Nova Scotia]; and a B. Sc. (Hons) in Biochemistry from Mount Allison University [New Burnswick].  His primary interest is in science policy and the public administration of research; he has worked in science and technology policy or research administrative positions for Environment Canada, Natural Resources Canada, the Privy Council Office, as well as the Nunavut Research Institute. [emphasis mine]

I don’t know what Dr. Isnor’s work is like but I’m hopeful he (along with Spiteri) will be able to provide a less ‘big city’ perspective to the proceedings.

(For those unfamiliar with Canadian cities, Montreal [three expert panelists] is the second largest city in the country, Ottawa [two expert panelists] as the capital has an outsize view of itself, Vancouver [one expert panelist] is the third or fourth largest city in the country for a total of six big city representatives out of eight Canadian expert panelists.)

Ross D. King, professor of machine intelligence at Sweden’s Chalmers University of Technology, might be best known for Adam, also known as, Robot Scientist. Here’s more about King, from his Wikipedia entry (Note: Links have been removed),

King completed a Bachelor of Science degree in Microbiology at the University of Aberdeen in 1983 and went on to study for a Master of Science degree in Computer Science at the University of Newcastle in 1985. Following this, he completed a PhD at The Turing Institute [emphasis mine] at the University of Strathclyde in 1989[3] for work on developing machine learning methods for protein structure prediction.[7]

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King’s research interests are in the automation of science, drug design, AI, machine learning and synthetic biology.[8][9] He is probably best known for the Robot Scientist[4][10][11][12][13][14][15][16][17] project which has created a robot that can:

hypothesize to explain observations

devise experiments to test these hypotheses

physically run the experiments using laboratory robotics

interpret the results from the experiments

repeat the cycle as required

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The Robot Scientist Wikipedia entry has this to add,

… a laboratory robot created and developed by a group of scientists including Ross King, Kenneth Whelan, Ffion Jones, Philip Reiser, Christopher Bryant, Stephen Muggleton, Douglas Kell and Steve Oliver.[2][6][7][8][9][10]

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… Adam became the first machine in history to have discovered new scientific knowledge independently of its human creators.[5][17][18]

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Sabina Leonelli, professor of philosophy and history of science at the University of Exeter, is the only person for whom I found a Twitter feed (@SabinaLeonelli). Here’s a bit more from her Wikipedia entry Note: Links have been removed),

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Originally from Italy, Leonelli moved to the UK for a BSc degree in History, Philosophy and Social Studies of Science at University College London and a MSc degree in History and Philosophy of Science at the London School of Economics. Her doctoral research was carried out in the Netherlands at the Vrije Universiteit Amsterdam with Henk W. de Regt and Hans Radder. Before joining the Exeter faculty, she was a research officer under Mary S. Morgan at the Department of Economic History of the London School of Economics.

Leonelli is the Co-Director of the Exeter Centre for the Study of the Life Sciences (Egenis)[3] and a Turing Fellow at the Alan Turing Institute [emphases mine] in London.[4] She is also Editor-in-Chief of the international journal History and Philosophy of the Life Sciences[5] and Associate Editor for the Harvard Data Science Review.[6] She serves as External Faculty for the Konrad Lorenz Institute for Evolution and Cognition Research.[7]

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Notice that Ross King and Sabina Leonelli both have links to The Alan Turing Institute (“We believe data science and artificial intelligence will change the world”), although the institute’s link to the University of Strathclyde (Scotland) where King studied seems a bit tenuous.

Do check out Leonelli’s profile at the University of Exeter as it’s comprehensive.

Raymond J. Spiteri, professor and director of the Centre for High Performance Computing, Department of Computer Science at the University of Saskatchewan, has a profile page at the university the likes of which I haven’t seen in several years perhaps due to its 2013 origins. His other university profile page can best be described as minimalist.

His Canadian Applied and Industrial Mathematics Society (CAIMS) biography page could be described as less charming (to me) than the 2013 profile but it is easier to read,

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Raymond Spiteri is a Professor in the Department of Computer Science at the University of Saskatchewan. He performed his graduate work as a member of the Institute for Applied Mathematics at the University of British Columbia. He was a post-doctoral fellow at McGill University and held faculty positions at Acadia University and Dalhousie University before joining USask in 2004. He serves on the Executive Committee of the WestGrid High-Performance Computing Consortium with Compute/Calcul Canada. He was a MITACS Project Leader from 2004-2012 and served in the role of Mitacs Regional Scientific Director for the Prairie Provinces between 2008 and 2011.

Spiteri’s areas of research are numerical analysis, scientific computing, and high-performance computing. His area of specialization is the analysis and implementation of efficient time-stepping methods for differential equations. He actively collaborates with scientists, engineers, and medical experts of all flavours. He also has a long record of industry collaboration with companies such as IBM and Boeing.

Spiteri has been lifetime member of CAIMS/SCMAI since 2000. He helped co-organize the 2004 Annual Meeting at Dalhousie and served on the Cecil Graham Doctoral Dissertation Award Committee from 2005 to 2009, acting as chair from 2007. He has been an active participant in CAIMS, serving several times on the Scientific Committee for the Annual Meeting, as well as frequently attending and organizing mini-symposia. Spiteri believes it is important for applied mathematics to play a major role in the efforts to meet Canada’s most pressing societal challenges, including the sustainability of our healthcare system, our natural resources, and the environment.

A last look at Spiteri’s 2013 profile gave me this (Note: Links have been removed),

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Another biographical note: I obtained my B.Sc. degree in Applied Mathematics from the University of Western Ontario [also known as, Western University] in 1990. My advisor was Dr. M.A.H. (Paddy) Nerenberg, after whom the Nerenberg Lecture Series is named. Here is an excerpt from the description, put here is his honour, as a model for the rest of us:

The Nerenberg Lecture Series is first and foremost about people and ideas. Knowledge is the true treasure of humanity, accrued and passed down through the generations. Some of it, particularly science and its language, mathematics, is closed in practice to many because of technical barriers that can only be overcome at a high price. These technical barriers form part of the remarkable fractures that have formed in our legacy of knowledge. We are so used to those fractures that they have become almost invisible to us, but they are a source of profound confusion about what is known.

The Nerenberg Lecture is named after the late Morton (Paddy) Nerenberg, a much-loved professor and researcher born on 17 March– hence his nickname. He was a Professor at Western for more than a quarter century, and a founding member of the Department of Applied Mathematics there. A successful researcher and accomplished teacher, he believed in the unity of knowledge, that scientific and mathematical ideas belong to everyone, and that they are of human importance. He regretted that they had become inaccessible to so many, and anticipated serious consequences from it. [emphases mine] The series honors his appreciation for the democracy of ideas. He died in 1993 at the age of 57.

So, we have the expert panel.

Thoughts about the panel and the report

As I’ve noted previously here and elsewhere, assembling any panels whether they’re for a single event or for a longer term project such as producing a report is no easy task. Looking at the panel, there’s some arts representation, smaller urban centres are also represented, and some of the members have experience in more than one region in Canada. I was also much encouraged by Spiteri’s acknowledgement of his advisor’s, Morton (Paddy) Nerenberg, passionate commitment to the idea that “scientific and mathematical ideas belong to everyone.”

Kudos to the Council of Canadian Academies (CCA) organizers.

That said, this looks like an exceptionally Eurocentric panel. Unusually, there’s no representation from the US unless you count Chun who has spent the majority of her career in the US with only a little over two years at Simon Fraser University on Canada’s West Coast.

There’s weakness to a strategy (none of the ten or so CCA reports I’ve reviewed here deviates from this pattern) that seems to favour international participants from Europe and/or the US (also, sometimes, Australia/New Zealand). This leaves out giant chunks of the international community and brings us dangerously close to an echo chamber.

The same problem exists regionally and with various Canadian communities, which are acknowledged more in spirit than in actuality, e.g., the North, rural, indigenous, arts, etc.

Getting back to the ‘big city’ emphsais noted earlier, two people from Ottawa and three from Montreal; half of the expert panel lives within a two hour train ride of each other. (For those who don’t know, that’s close by Canadian standards. For comparison, a train ride from Vancouver to Seattle [US] is about four hours, a short trip when compared to a 24 hour train trip to the closest large Canadian cities.)

I appreciate that it’s not a simple problem but my concern is that it’s never acknowledged by the CCA. Perhaps they could include a section in the report acknowledging the issues and how the expert panel attempted to address them , in other words, transparency. Coincidentally, transparency, which has been related to trust, have both been identified as big issues with artificial intelligence.

As for solutions, these reports get sent to external reviewers and, prior to the report, outside experts are sometimes brought in as the panel readies itself. That would be two opportunities afforded by their current processes.

Anyway, good luck with the report and I look forward to seeing it.

The mystifying physics of paint-on semiconductors

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I was not expecting a Canadian connection but it seems we are heavily invested in this research at the Georgia Institute of Technology (Georgia Tech), from a March 19, 2018 news item on ScienceDaily,

Some novel materials that sound too good to be true turn out to be true and good. An emergent class of semiconductors, which could affordably light up our future with nuanced colors emanating from lasers, lamps, and even window glass, could be the latest example.

These materials are very radiant, easy to process from solution, and energy-efficient. The nagging question of whether hybrid organic-inorganic perovskites (HOIPs) could really work just received a very affirmative answer in a new international study led by physical chemists at the Georgia Institute of Technology.

A March 19,. 2018 Georgia Tech news release (also on EurekAlert), which originated the news item, provides more detail,

The researchers observed in an HOIP a “richness” of semiconducting physics created by what could be described as electrons dancing on chemical underpinnings that wobble like a funhouse floor in an earthquake. That bucks conventional wisdom because established semiconductors rely upon rigidly stable chemical foundations, that is to say, quieter molecular frameworks, to produce the desired quantum properties.

“We don’t know yet how it works to have these stable quantum properties in this intense molecular motion,” said first author Felix Thouin, a graduate research assistant at Georgia Tech. “It defies physics models we have to try to explain it. It’s like we need some new physics.”

Quantum properties surprise

Their gyrating jumbles have made HOIPs challenging to examine, but the team of researchers from a total of five research institutes in four countries succeeded in measuring a prototypical HOIP and found its quantum properties on par with those of established, molecularly rigid semiconductors, many of which are graphene-based.

“The properties were at least as good as in those materials and may be even better,” said Carlos Silva, a professor in Georgia Tech’s School of Chemistry and Biochemistry. Not all semiconductors also absorb and emit light well, but HOIPs do, making them optoelectronic and thus potentially useful in lasers, LEDs, other lighting applications, and also in photovoltaics.

The lack of molecular-level rigidity in HOIPs also plays into them being more flexibly produced and applied.

Silva co-led the study with physicist Ajay Ram Srimath Kandada. Their team published the results of their study on two-dimensional HOIPs on March 8, 2018, in the journal Physical Review Materials. Their research was funded by EU Horizon 2020, the Natural Sciences and Engineering Research Council of Canada, the Fond Québécois pour la Recherche, the [National] Research Council of Canada, and the National Research Foundation of Singapore. [emphases mine]

The ‘solution solution’

Commonly, semiconducting properties arise from static crystalline lattices of neatly interconnected atoms. In silicon, for example, which is used in most commercial solar cells, they are interconnected silicon atoms. The same principle applies to graphene-like semiconductors.

“These lattices are structurally not very complex,” Silva said. “They’re only one atom thin, and they have strict two-dimensional properties, so they’re much more rigid.”

“You forcefully limit these systems to two dimensions,” said Srimath Kandada, who is a Marie Curie International Fellow at Georgia Tech and the Italian Institute of Technology. “The atoms are arranged in infinitely expansive, flat sheets, and then these very interesting and desirable optoelectronic properties emerge.”

These proven materials impress. So, why pursue HOIPs, except to explore their baffling physics? Because they may be more practical in important ways.

“One of the compelling advantages is that they’re all made using low-temperature processing from solutions,” Silva said. “It takes much less energy to make them.”

By contrast, graphene-based materials are produced at high temperatures in small amounts that can be tedious to work with. “With this stuff (HOIPs), you can make big batches in solution and coat a whole window with it if you want to,” Silva said.

Funhouse in an earthquake

For all an HOIP’s wobbling, it’s also a very ordered lattice with its own kind of rigidity, though less limiting than in the customary two-dimensional materials.

“It’s not just a single layer,” Srimath Kandada said. “There is a very specific perovskite-like geometry.” Perovskite refers to the shape of an HOIPs crystal lattice, which is a layered scaffolding.

“The lattice self-assembles,” Srimath Kandada said, “and it does so in a three-dimensional stack made of layers of two-dimensional sheets. But HOIPs still preserve those desirable 2D quantum properties.”

Those sheets are held together by interspersed layers of another molecular structure that is a bit like a sheet of rubber bands. That makes the scaffolding wiggle like a funhouse floor.

“At room temperature, the molecules wiggle all over the place. That disrupts the lattice, which is where the electrons live. It’s really intense,” Silva said. “But surprisingly, the quantum properties are still really stable.”

Having quantum properties work at room temperature without requiring ultra-cooling is important for practical use as a semiconductor.

Going back to what HOIP stands for — hybrid organic-inorganic perovskites – this is how the experimental material fit into the HOIP chemical class: It was a hybrid of inorganic layers of a lead iodide (the rigid part) separated by organic layers (the rubber band-like parts) of phenylethylammonium (chemical formula (PEA)2PbI4).

The lead in this prototypical material could be swapped out for a metal safer for humans to handle before the development of an applicable material.

Electron choreography

HOIPs are great semiconductors because their electrons do an acrobatic square dance.

Usually, electrons live in an orbit around the nucleus of an atom or are shared by atoms in a chemical bond. But HOIP chemical lattices, like all semiconductors, are configured to share electrons more broadly.

Energy levels in a system can free the electrons to run around and participate in things like the flow of electricity and heat. The orbits, which are then empty, are called electron holes, and they want the electrons back.

“The hole is thought of as a positive charge, and of course, the electron has a negative charge,” Silva said. “So, hole and electron attract each other.”

The electrons and holes race around each other like dance partners pairing up to what physicists call an “exciton.” Excitons act and look a lot like particles themselves, though they’re not really particles.

Hopping biexciton light

In semiconductors, millions of excitons are correlated, or choreographed, with each other, which makes for desirable properties, when an energy source like electricity or laser light is applied. Additionally, excitons can pair up to form biexcitons, boosting the semiconductor’s energetic properties.

“In this material, we found that the biexciton binding energies were high,” Silva said. “That’s why we want to put this into lasers because the energy you input ends up to 80 or 90 percent as biexcitons.”

Biexcitons bump up energetically to absorb input energy. Then they contract energetically and pump out light. That would work not only in lasers but also in LEDs or other surfaces using the optoelectronic material.

“You can adjust the chemistry (of HOIPs) to control the width between biexciton states, and that controls the wavelength of the light given off,” Silva said. “And the adjustment can be very fine to give you any wavelength of light.”

That translates into any color of light the heart desires.

###

Coauthors of this paper were Stefanie Neutzner and Annamaria Petrozza from the Italian Institute of Technology (IIT); Daniele Cortecchia from IIT and Nanyang Technological University (NTU), Singapore; Cesare Soci from the Centre for Disruptive Photonic Technologies, Singapore; Teddy Salim and Yeng Ming Lam from NTU; and Vlad Dragomir and Richard Leonelli from the University of Montreal. …

Three Canadian science funding agencies plus European and Singaporean science funding agencies but not one from the US ? That’s a bit unusual for research undertaken at a US educational institution.

In any event, here’s a link to and a citation for the paper,

Stable biexcitons in two-dimensional metal-halide perovskites with strong dynamic lattice disorder by Félix Thouin, Stefanie Neutzner, Daniele Cortecchia, Vlad Alexandru Dragomir, Cesare Soci, Teddy Salim, Yeng Ming Lam, Richard Leonelli, Annamaria Petrozza, Ajay Ram Srimath Kandada, and Carlos Silva. Phys. Rev. Materials 2, 034001 – Published 8 March 2018

This paper is behind a paywall.

AI (artificial intelligence) for Good Global Summit from May 15 – 17, 2018 in Geneva, Switzerland: details and an interview with Frederic Werner

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With all the talk about artificial intelligence (AI), a lot more attention seems to be paid to apocalyptic scenarios: loss of jobs, financial hardship, loss of personal agency and privacy, and more with all of these impacts being described as global. Still, there are some folks who are considering and working on ‘AI for good’.

If you’d asked me, the International Telecommunications Union (ITU) would not have been my first guess (my choice would have been United Nations Educational, Scientific and Cultural Organization [UNESCO]) as an agency likely to host the 2018 AI for Good Global Summit. But, it turns out the ITU is a UN (United Nations agency) and, according to its Wikipedia entry, it’s an intergovernmental public-private partnership, which may explain the nature of the participants in the upcoming summit.

The news

First, there’s a May 4, 2018 ITU media advisory (received via email or you can find the full media advisory here) about the upcoming summit,

Artificial Intelligence (AI) is now widely identified as being able to address the greatest challenges facing humanity – supporting innovation in fields ranging from crisis management and healthcare to smart cities and communications networking.

The second annual ‘AI for Good Global Summit’ will take place 15-17 May [2018] in Geneva, and seeks to leverage AI to accelerate progress towards the United Nations’ Sustainable Development Goals and ultimately benefit humanity.

WHAT: Global event to advance ‘AI for Good’ with the participation of internationally recognized AI experts. The programme will include interactive high-level panels, while ‘AI Breakthrough Teams’ will propose AI strategies able to create impact in the near term, guided by an expert audience of mentors representing government, industry, academia and civil society – through interactive sessions. The summit will connect AI innovators with public and private-sector decision-makers, building collaboration to take promising strategies forward.

A special demo & exhibit track will feature innovative applications of AI designed to: protect women from sexual violence, avoid infant crib deaths, end child abuse, predict oral cancer, and improve mental health treatments for depression – as well as interactive robots including: Alice, a Dutch invention designed to support the aged; iCub, an open-source robot; and Sophia, the humanoid AI robot.

WHEN: 15-17 May 2018, beginning daily at 9 AM

WHERE: ITU Headquarters, 2 Rue de Varembé, Geneva, Switzerland (Please note: entrance to ITU is now limited for all visitors to the Montbrillant building entrance only on rue Varembé).

WHO: Confirmed participants to date include expert representatives from: Association for Computing Machinery, Bill and Melinda Gates Foundation, Cambridge University, Carnegie Mellon, Chan Zuckerberg Initiative, Consumer Trade Association, Facebook, Fraunhofer, Google, Harvard University, IBM Watson, IEEE, Intellectual Ventures, ITU, Microsoft, Massachusetts Institute of Technology (MIT), Partnership on AI, Planet Labs, Shenzhen Open Innovation Lab, University of California at Berkeley, University of Tokyo, XPRIZE Foundation, Yale University – and the participation of “Sophia” the humanoid robot and “iCub” the EU open source robotcub.

The interview

Frederic Werner, Senior Communications Officer at the International Telecommunication Union and** one of the organizers of the AI for Good Global Summit 2018 kindly took the time to speak to me and provide a few more details about the upcoming event.

Werner noted that the 2018 event grew out of a much smaller 2017 ‘workshop’ and first of its kind, about beneficial AI which this year has ballooned in size to 91 countries (about 15 participants are expected from Canada), 32 UN agencies, and substantive representation from the private sector. The 2017 event featured Dr. Yoshua Bengio of the University of Montreal  (Université de Montréal) was a featured speaker.

“This year, we’re focused on action-oriented projects that will help us reach our Sustainable Development Goals (SDGs) by 2030. We’re looking at near-term practical AI applications,” says Werner. “We’re matchmaking problem-owners and solution-owners.”

Academics, industry professionals, government officials, and representatives from UN agencies are gathering  to work on four tracks/themes:

  • ​AI and satellite imagery
  • AI and health
  • AI ​and smart cities & communities
  • Trust in AI

In advance of this meeting, the group launched an AI repository (an action item from the 2017 meeting) on April 25, 2018 inviting people to list their AI projects (from the ITU’s April 25, 2018? AI repository news announcement),

ITU has just launched an AI Repository where anyone working in the field of artificial intelligence (AI) can contribute key information about how to leverage AI to help solve humanity’s greatest challenges.

This is the only global repository that identifies AI-related projects, research initiatives, think-tanks and organizations that aim to accelerate progress on the 17 United Nations’ Sustainable Development Goals (SDGs).

To submit a project, just press ‘Submit’ on the AI Repository site and fill in the online questionnaire, providing all relevant details of your project. You will also be asked to map your project to the relevant World Summit on the Information Society (WSIS) action lines and the SDGs. Approved projects will be officially registered in the repository database.

Benefits of participation on the AI Repository include:

WSIS Prizes recognize individuals, governments, civil society, local, regional and international agencies, research institutions and private-sector companies for outstanding success in implementing development oriented strategies that leverage the power of AI and ICTs.

Creating the AI Repository was one of the action items of last year’s AI for Good Global Summit.

We are looking forward to your submissions.

If you have any questions, please send an email to: ai@itu.int

“Your project won’t be visible immediately as we have to vet the submissions to weed out spam-type material and projects that are not in line with our goals,” says Werner. That said, there are already 29 projects in the repository. As you might expect, the UK, China, and US are in the repository but also represented are Egypt, Uganda, Belarus, Serbia, Peru, Italy, and other countries not commonly cited when discussing AI research.

Werner also pointed out in response to my surprise over the ITU’s role with regard to this AI initiative that the ITU is the only UN agency which has 192* member states (countries), 150 universities, and over 700 industry members as well as other member entities, which gives them tremendous breadth of reach. As well, the organization, founded originally in 1865 as the International Telegraph Convention, has extensive experience with global standardization in the information technology and telecommunications industries. (See more in their Wikipedia entry.)

Finally

There is a bit more about the summit on the ITU’s AI for Good Global Summit 2018 webpage,

The 2nd edition of the AI for Good Global Summit will be organized by ITU in Geneva on 15-17 May 2018, in partnership with XPRIZE Foundation, the global leader in incentivized prize competitions, the Association for Computing Machinery (ACM) and sister United Nations agencies including UNESCO, UNICEF, UNCTAD, UNIDO, Global Pulse, UNICRI, UNODA, UNIDIR, UNODC, WFP, IFAD, UNAIDS, WIPO, ILO, UNITAR, UNOPS, OHCHR, UN University, WHO, UNEP, ICAO, UNDP, The World Bank, UN DESA, CTBTO, UNISDR, UNOG, UNOOSA, UNFPA, UNECE, UNDPA, and UNHCR.

The AI for Good series is the leading United Nations platform for dialogue on AI. The action​​-oriented 2018 summit will identify practical applications of AI and supporting strategies to improve the quality and sustainability of life on our planet. The summit will continue to formulate strategies to ensure trusted, safe and inclusive development of AI technologies and equitable access to their benefits.

While the 2017 summit sparked the first ever inclusive global dialogue on beneficial AI, the action-oriented 2018 summit will focus on impactful AI solutions able to yield long-term benefits and help achieve the Sustainable Development Goals. ‘Breakthrough teams’ will demonstrate the potential of AI to map poverty and aid with natural disasters using satellite imagery, how AI could assist the delivery of citizen-centric services in smart cities, and new opportunities for AI to help achieve Universal Health Coverage, and finally to help achieve transparency and explainability in AI algorithms.

Teams will propose impactful AI strategies able to be enacted in the near term, guided by an expert audience of mentors representing government, industry, academia and civil society. Strategies will be evaluated by the mentors according to their feasibility and scalability, potential to address truly global challenges, degree of supporting advocacy, and applicability to market failures beyond the scope of government and industry. The exercise will connect AI innovators with public and private-sector decision-makers, building collaboration to take promising strategies forward.

“As the UN specialized agency for information and communication technologies, ITU is well placed to guide AI innovation towards the achievement of the UN Sustainable Development ​Goals. We are providing a neutral close quotation markplatform for international dialogue aimed at ​building a ​common understanding of the capabilities of emerging AI technologies.​​” Houlin Zhao, Secretary General ​of ITU​

Should you be close to Geneva, it seems that registration is still open. Just go to the ITU’s AI for Good Global Summit 2018 webpage, scroll the page down to ‘Documentation’ and you will find a link to the invitation and a link to online registration. Participation is free but I expect that you are responsible for your travel and accommodation costs.

For anyone unable to attend in person, the summit will be livestreamed (webcast in real time) and you can watch the sessions by following the link below,

https://www.itu.int/en/ITU-T/AI/2018/Pages/webcast.aspx

For those of us on the West Coast of Canada and other parts distant to Geneva, you will want to take the nine hour difference between Geneva (Switzerland) and here into account when viewing the proceedings. If you can’t manage the time difference, the sessions are being recorded and will be posted at a later date.

*’132 member states’ corrected to ‘192 member states’ on May 11, 2018 at 1500 hours PDT.

*Redundant ‘and’ removed on July 19, 2018.

Shooting drugs to an infection site with a slingshot

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It seems as if I’ve been writing up nanomedicine research a lot lately, so I would have avoided this piece. However, since I do try to cover Canadian nanotechnology regardless of the topic and this work features researchers from l’Université de Montréal (Québec, Canada), here’s one of the latest innovations in the field of nanomedicine. (I have some additional comments about the nano scene in Canada and one major issue concerning nanomedicine at the end of this posting.) From a May 8, 2017 news item on ScienceDaily,

An international team of researchers from the University of Rome Tor Vergata and the University of Montreal has reported, in a paper published this week in Nature Communications, the design and synthesis of a nanoscale molecular slingshot made of DNA that is 20,000 times smaller than a human hair. This molecular slingshot could “shoot” and deliver drugs at precise locations in the human body once triggered by specific disease markers.

A May 8, 2017 University of Montreal news release (also on EurekAlert), which originated the news item, delves further into the research (Note: A link has been removed),

The molecular slingshot is only a few nanometres long and is composed of a synthetic DNA strand that can load a drug and then effectively act as the rubber band of the slingshot. The two ends of this DNA “rubber band” contain two anchoring moieties that can specifically stick to a target antibody, a Y-shaped protein expressed by the body in response to different pathogens such as bacteria and viruses. When the anchoring moieties of the slingshot recognize and bind to the arms of the target antibody the DNA “rubber band” is stretched and the loaded drug is released.

“One impressive feature about this molecular slingshot,” says Francesco Ricci, Associate Professor of Chemistry at the University of Rome Tor Vergata, “is that it can only be triggered by the specific antibody recognizing the anchoring tags of the DNA ‘rubber band’. By simply changing these tags, one can thus program the slingshot to release a drug in response to a variety of specific antibodies. Since different antibodies are markers of different diseases, this could become a very specific weapon in the clinician’s hands.”

“Another great property of our slingshot,” adds Alexis Vallée-Bélisle, Assistant Professor in the Department of Chemistry at the University of Montreal, “is its high versatility. For example, until now we have demonstrated the working principle of the slingshot using three different trigger antibodies, including an HIV antibody, and employing nucleic acids as model drugs. But thanks to the high programmability of DNA chemistry, one can now design the DNA slingshot to ‘shoot’ a wide range of threrapeutic molecules.”

“Designing this molecular slingshot was a great challenge,” says Simona Ranallo, a postdoctoral researcher in Ricci’s team and principal author of the new study. “It required a long series of experiments to find the optimal design, which keeps the drug loaded in ‘rubber band’ in the absence of the antibody, without affecting too much its shooting efficiency once the antibody triggers the slingshot.”

The group of researchers is now eager to adapt the slingshot for the delivery of clinically relevant drugs, and to demonstrate its clinical efficiency. [emphasis mine] “We envision that similar molecular slingshots may be used in the near future to deliver drugs to specific locations in the body. This would drastically improve the efficiency of drugs as well as decrease their toxic secondary effects,” concludes Ricci.

Here’s a link to and a citation for the paper,

Antibody-powered nucleic acid release using a DNA-based nanomachine by Simona Ranallo, Carl Prévost-Tremblay, Andrea Idili, Alexis Vallée-Bélisle, & Francesco Ricci. Nature Communications 8, Article number: 15150 (2017) doi:10.1038/ncomms15150 Published online: 08 May 2017

This is an open access paper.

A couple of comments

The Canadian nanotechnology scene is pretty much centered in Alberta and Québec. The two provinces have invested a fair amount of money in their efforts. Despite the fact that the province of Alberta also hosts the federal government’s National Institute of Nanotechnology, it seems that the province of Québec is the one making the most progress in its various ‘nano’ fields of endeavour. Another province that should be mentioned with regard to its ‘nano’ efforts is Ontario. As far as I can tell, nanotechnology there doesn’t enjoy the same level of provincial funding support as the other two but there is some important work coming out of Ontario.

My other comment has to do with nanomedicine. While it is an exciting field, there is a tendency toward a certain hyperbole. For anyone who got excited about the ‘slingshot’, don’t forget this hasn’t been tested on any conditions close to the conditions found in a human body nor have they even used, “... clinically relevant drugs,  … .”  It’s also useful to know that less than 1% of the drugs used in nanoparticle-delivery systems make their way to the affected site (from an April 27, 2016 posting about research investigating the effectiveness of nanoparticle-based drug delivery systems). By the way, it was a researcher at the University of Toronto (Ontario, Canada) who first noted this phenomenon after a meta-analysis of the research,

…

More generally, the authors argue that, in order to increase nanoparticle delivery efficiency, a systematic and coordinated long-term strategy is necessary. To build a strong foundation for the field of cancer nanomedicine, researchers will need to understand a lot more about the interactions between nanoparticles and the body’s various organs than they do today. …

It’s not clear from the news release, the paper, or the May 8, 2017 article by Sherry Noik for the Canadian Broadcasting Corporation’s News Online website, how this proposed solution would be administered but presumably the same factors which affect other nano-based drug deliveries could affect this new one,

Scientists have for many years been working on improving therapies like chemo and radiation on that score, but most efforts have focused on modifying the chemistry rather than altering the delivery of the drug.

“It’s all about tuning the concentration of the drug optimally in the body: high concentration where you want it to be active, and low concentration where you don’t want to affect other healthy parts,” says Prof. Alexis Vallée-Bélisle of the University of Montreal, co-author of the report published this week in Nature Communications.

“If you can increase the concentration of that drug at the specific location, that drug will be more efficient,” he told CBC News in an interview.

‘Like a weapon’

Restricting the movement of the drug also reduces potentially harmful secondary effects on other parts of the body — for instance, the hair loss that can result from toxic cancer treatments, or the loss of so-called good bacteria due to antibiotic use.

The idea of the slingshot is to home in on the target cells at a molecular level.

…

The two ends of the strand anchor themselves to the antibody, stretching the strand taut and catapulting the drug to its target.

“Imagine our slingshot like a weapon, and this weapon is being used by our own antibody,” said Vallée-Bélisle, who heads the Laboratory of Biosensors & Nanomachines at U of M. “We design a specific weapon targeting, for example, HIV. We provide the weapon in the body with the bullet — the drug. If the right solider is there, the soldier can use the weapon and shoot the problem.”

Equally important: if the wrong soldier is present, the weapon won’t be deployed.

So rather than delay treatment for an unidentified infection that could be either viral or bacterial, a patient could receive the medication for both and their body would only use the one it needed.

Getting back to my commentary, how does the drug get to its target? Through the bloodstream?  Does it get passed through various organs? How do we increase the amount of medication (in nano-based drug delivery systems) reaching affected areas from less than 1%?

The researchers deserve to be congratulated for this work and given much encouragement and thanks as they grapple with the questions I’ve posed and with all of the questions I don’t know how to ask.

Vector Institute and Canada’s artificial intelligence sector

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On the heels of the March 22, 2017 federal budget announcement of $125M for a Pan-Canadian Artificial Intelligence Strategy, the University of Toronto (U of T) has announced the inception of the Vector Institute for Artificial Intelligence in a March 28, 2017 news release by Jennifer Robinson (Note: Links have been removed),

A team of globally renowned researchers at the University of Toronto is driving the planning of a new institute staking Toronto’s and Canada’s claim as the global leader in AI.

Geoffrey Hinton, a University Professor Emeritus in computer science at U of T and vice-president engineering fellow at Google, will serve as the chief scientific adviser of the newly created Vector Institute based in downtown Toronto.

“The University of Toronto has long been considered a global leader in artificial intelligence research,” said U of T President Meric Gertler. “It’s wonderful to see that expertise act as an anchor to bring together researchers, government and private sector actors through the Vector Institute, enabling them to aim even higher in leading advancements in this fast-growing, critical field.”

As part of the Government of Canada’s Pan-Canadian Artificial Intelligence Strategy, Vector will share $125 million in federal funding with fellow institutes in Montreal and Edmonton. All three will conduct research and secure talent to cement Canada’s position as a world leader in AI.

In addition, Vector is expected to receive funding from the Province of Ontario and more than 30 top Canadian and global companies eager to tap this pool of talent to grow their businesses. The institute will also work closely with other Ontario universities with AI talent.

(See my March 24, 2017 posting; scroll down about 25% for the science part, including the Pan-Canadian Artificial Intelligence Strategy of the budget.)

Not obvious in last week’s coverage of the Pan-Canadian Artificial Intelligence Strategy is that the much lauded Hinton has been living in the US and working for Google. These latest announcements (Pan-Canadian AI Strategy and Vector Institute) mean that he’s moving back.

A March 28, 2017 article by Kate Allen for TorontoStar.com provides more details about the Vector Institute, Hinton, and the Canadian ‘brain drain’ as it applies to artificial intelligence, (Note:  A link has been removed)

Toronto will host a new institute devoted to artificial intelligence, a major gambit to bolster a field of research pioneered in Canada but consistently drained of talent by major U.S. technology companies like Google, Facebook and Microsoft.

The Vector Institute, an independent non-profit affiliated with the University of Toronto, will hire about 25 new faculty and research scientists. It will be backed by more than $150 million in public and corporate funding in an unusual hybridization of pure research and business-minded commercial goals.

The province will spend $50 million over five years, while the federal government, which announced a $125-million Pan-Canadian Artificial Intelligence Strategy in last week’s budget, is providing at least $40 million, backers say. More than two dozen companies have committed millions more over 10 years, including $5 million each from sponsors including Google, Air Canada, Loblaws, and Canada’s five biggest banks [Bank of Montreal (BMO). Canadian Imperial Bank of Commerce ({CIBC} President’s Choice Financial},  Royal Bank of Canada (RBC), Scotiabank (Tangerine), Toronto-Dominion Bank (TD Canada Trust)].

The mode of artificial intelligence that the Vector Institute will focus on, deep learning, has seen remarkable results in recent years, particularly in image and speech recognition. Geoffrey Hinton, considered the “godfather” of deep learning for the breakthroughs he made while a professor at U of T, has worked for Google since 2013 in California and Toronto.

Hinton will move back to Canada to lead a research team based at the tech giant’s Toronto offices and act as chief scientific adviser of the new institute.

…

Researchers trained in Canadian artificial intelligence labs fill the ranks of major technology companies, working on tools like instant language translation, facial recognition, and recommendation services. Academic institutions and startups in Toronto, Waterloo, Montreal and Edmonton boast leaders in the field, but other researchers have left for U.S. universities and corporate labs.

The goals of the Vector Institute are to retain, repatriate and attract AI talent, to create more trained experts, and to feed that expertise into existing Canadian companies and startups.

…

Hospitals are expected to be a major partner, since health care is an intriguing application for AI. Last month, researchers from Stanford University announced they had trained a deep learning algorithm to identify potentially cancerous skin lesions with accuracy comparable to human dermatologists. The Toronto company Deep Genomics is using deep learning to read genomes and identify mutations that may lead to disease, among other things.

Intelligent algorithms can also be applied to tasks that might seem less virtuous, like reading private data to better target advertising. Zemel [Richard Zemel, the institute’s research director and a professor of computer science at U of T] says the centre is creating an ethics working group [emphasis mine] and maintaining ties with organizations that promote fairness and transparency in machine learning. As for privacy concerns, “that’s something we are well aware of. We don’t have a well-formed policy yet but we will fairly soon.”

The institute’s annual funding pales in comparison to the revenues of the American tech giants, which are measured in tens of billions. The risk the institute’s backers are taking is simply creating an even more robust machine learning PhD mill for the U.S.

“They obviously won’t all stay in Canada, but Toronto industry is very keen to get them,” Hinton said. “I think Trump might help there.” Two researchers on Hinton’s new Toronto-based team are Iranian, one of the countries targeted by U.S. President Donald Trump’s travel bans.

Ethics do seem to be a bit of an afterthought. Presumably the Vector Institute’s ‘ethics working group’ won’t include any regular folks. Is there any thought to what the rest of us think about these developments? As there will also be some collaboration with other proposed AI institutes including ones at the University of Montreal (Université de Montréal) and the University of Alberta (Kate McGillivray’s article coming up shortly mentions them), might the ethics group be centered in either Edmonton or Montreal? Interestingly, two Canadians (Timothy Caulfield at the University of Alberta and Eric Racine at Université de Montréa) testified at the US Commission for the Study of Bioethical Issues Feb. 10 – 11, 2014 meeting, the Brain research, ethics, and nanotechnology. Still speculating here but I imagine Caulfield and/or Racine could be persuaded to extend their expertise in ethics and the human brain to AI and its neural networks.

Getting back to the topic at hand the ‘AI sceneCanada’, Allen’s article is worth reading in its entirety if you have the time.

Kate McGillivray’s March 29, 2017 article for the Canadian Broadcasting Corporation’s (CBC) news online provides more details about the Canadian AI situation and the new strategies,

With artificial intelligence set to transform our world, a new institute is putting Toronto to the front of the line to lead the charge.

The Vector Institute for Artificial Intelligence, made possible by funding from the federal government revealed in the 2017 budget, will move into new digs in the MaRS Discovery District by the end of the year.

…

Vector’s funding comes partially from a $125 million investment announced in last Wednesday’s federal budget to launch a pan-Canadian artificial intelligence strategy, with similar institutes being established in Montreal and Edmonton.

“[A.I.] cuts across pretty well every sector of the economy,” said Dr. Alan Bernstein, CEO and president of the Canadian Institute for Advanced Research, the organization tasked with administering the federal program.

“Silicon Valley and England and other places really jumped on it, so we kind of lost the lead a little bit. I think the Canadian federal government has now realized that,” he said.

Stopping up the brain drain

Critical to the strategy’s success is building a homegrown base of A.I. experts and innovators — a problem in the last decade, despite pioneering work on so-called “Deep Learning” by Canadian scholars such as Yoshua Bengio and Geoffrey Hinton, a former University of Toronto professor who will now serve as Vector’s chief scientific advisor.

With few university faculty positions in Canada and with many innovative companies headquartered elsewhere, it has been tough to keep the few graduates specializing in A.I. in town.

“We were paying to educate people and shipping them south,” explained Ed Clark, chair of the Vector Institute and business advisor to Ontario Premier Kathleen Wynne.

…

The existence of that “fantastic science” will lean heavily on how much buy-in Vector and Canada’s other two A.I. centres get.

Toronto’s portion of the $125 million is a “great start,” said Bernstein, but taken alone, “it’s not enough money.”

“My estimate of the right amount of money to make a difference is a half a billion or so, and I think we will get there,” he said.

Jessica Murphy’s March 29, 2017 article for the British Broadcasting Corporation’s (BBC) news online offers some intriguing detail about the Canadian AI scene,

Canadian researchers have been behind some recent major breakthroughs in artificial intelligence. Now, the country is betting on becoming a big player in one of the hottest fields in technology, with help from the likes of Google and RBC [Royal Bank of Canada].

In an unassuming building on the University of Toronto’s downtown campus, Geoff Hinton laboured for years on the “lunatic fringe” of academia and artificial intelligence, pursuing research in an area of AI called neural networks.

Also known as “deep learning”, neural networks are computer programs that learn in similar way to human brains. The field showed early promise in the 1980s, but the tech sector turned its attention to other AI methods after that promise seemed slow to develop.

“The approaches that I thought were silly were in the ascendancy and the approach that I thought was the right approach was regarded as silly,” says the British-born [emphasis mine] professor, who splits his time between the university and Google, where he is a vice-president of engineering fellow.

…

Neural networks are used by the likes of Netflix to recommend what you should binge watch and smartphones with voice assistance tools. Google DeepMind’s AlphaGo AI used them to win against a human in the ancient game of Go in 2016.

…

Foteini Agrafioti, who heads up the new RBC Research in Machine Learning lab at the University of Toronto, said those recent innovations made AI attractive to researchers and the tech industry.

“Anything that’s powering Google’s engines right now is powered by deep learning,” she says.

Developments in the field helped jumpstart innovation and paved the way for the technology’s commercialisation. They also captured the attention of Google, IBM and Microsoft, and kicked off a hiring race in the field.

The renewed focus on neural networks has boosted the careers of early Canadian AI machine learning pioneers like Hinton, the University of Montreal’s Yoshua Bengio, and University of Alberta’s Richard Sutton.

Money from big tech is coming north, along with investments by domestic corporations like banking multinational RBC and auto parts giant Magna, and millions of dollars in government funding.

…

Former banking executive Ed Clark will head the institute, and says the goal is to make Toronto, which has the largest concentration of AI-related industries in Canada, one of the top five places in the world for AI innovation and business.

The founders also want it to serve as a magnet and retention tool for top talent aggressively head-hunted by US firms.

Clark says they want to “wake up” Canadian industry to the possibilities of AI, which is expected to have a massive impact on fields like healthcare, banking, manufacturing and transportation.

…

Google invested C$4.5m (US$3.4m/£2.7m) last November [2016] in the University of Montreal’s Montreal Institute for Learning Algorithms.

Microsoft is funding a Montreal startup, Element AI. The Seattle-based company also announced it would acquire Montreal-based Maluuba and help fund AI research at the University of Montreal and McGill University.

Thomson Reuters and General Motors both recently moved AI labs to Toronto.

…

RBC is also investing in the future of AI in Canada, including opening a machine learning lab headed by Agrafioti, co-funding a program to bring global AI talent and entrepreneurs to Toronto, and collaborating with Sutton and the University of Alberta’s Machine Intelligence Institute.

…

Canadian tech also sees the travel uncertainty created by the Trump administration in the US as making Canada more attractive to foreign talent. (One of Clark’s the selling points is that Toronto as an “open and diverse” city).

…

This may reverse the ‘brain drain’ but it appears Canada’s role as a ‘branch plant economy’ for foreign (usually US) companies could become an important discussion once more. From the ‘Foreign ownership of companies of Canada’ Wikipedia entry (Note: Links have been removed),

Historically, foreign ownership was a political issue in Canada in the late 1960s and early 1970s, when it was believed by some that U.S. investment had reached new heights (though its levels had actually remained stable for decades), and then in the 1980s, during debates over the Free Trade Agreement.

But the situation has changed, since in the interim period Canada itself became a major investor and owner of foreign corporations. Since the 1980s, Canada’s levels of investment and ownership in foreign companies have been larger than foreign investment and ownership in Canada. In some smaller countries, such as Montenegro, Canadian investment is sizable enough to make up a major portion of the economy. In Northern Ireland, for example, Canada is the largest foreign investor. By becoming foreign owners themselves, Canadians have become far less politically concerned about investment within Canada.

Of note is that Canada’s largest companies by value, and largest employers, tend to be foreign-owned in a way that is more typical of a developing nation than a G8 member. The best example is the automotive sector, one of Canada’s most important industries. It is dominated by American, German, and Japanese giants. Although this situation is not unique to Canada in the global context, it is unique among G-8 nations, and many other relatively small nations also have national automotive companies.

It’s interesting to note that sometimes Canadian companies are the big investors but that doesn’t change our basic position. And, as I’ve noted in other postings (including the March 24, 2017 posting), these government investments in science and technology won’t necessarily lead to a move away from our ‘branch plant economy’ towards an innovative Canada.

You can find out more about the Vector Institute for Artificial Intelligence here.

BTW, I noted that reference to Hinton as ‘British-born’ in the BBC article. He was educated in the UK and subsidized by UK taxpayers (from his Wikipedia entry; Note: Links have been removed),

Hinton was educated at King’s College, Cambridge graduating in 1970, with a Bachelor of Arts in experimental psychology.[1] He continued his study at the University of Edinburgh where he was awarded a PhD in artificial intelligence in 1977 for research supervised by H. Christopher Longuet-Higgins.[3][12]

It seems Canadians are not the only ones to experience  ‘brain drains’.

Finally, I wrote at length about a recent initiative taking place between the University of British Columbia (Vancouver, Canada) and the University of Washington (Seattle, Washington), the Cascadia Urban Analytics Cooperative in a Feb. 28, 2017 posting noting that the initiative is being funded by Microsoft to the tune $1M and is part of a larger cooperative effort between the province of British Columbia and the state of Washington. Artificial intelligence is not the only area where US technology companies are hedging their bets (against Trump’s administration which seems determined to terrify people from crossing US borders) by investing in Canada.

For anyone interested in a little more information about AI in the US and China, there’s today’s (March 31, 2017)earlier posting: China, US, and the race for artificial intelligence research domination.